[ { "uniprot_canonical_ac": "O70240-1", "uniprot_id": "AXIN2_RAT", "mass": 92948.0, "length": 838, "protein_name": "Axin-2", "gene_name": "Axin2", "organism": "Rat", "refseq_name": "axin-2", "refseq_ac": "NP_077331", "gene_names_uniprotkb": "Axin2", "gene_names_refseq": "Axin2; axil; axin-2", "protein_names_uniprotkb": "Axin-2; Axil; Axin-like protein; Axis inhibition protein 2; Conductin", "protein_names_refseq": "axin-2; axin-like protein; axis inhibition protein 2; conductin", "tax_id": 10116, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); orofacial cleft (Disease Ontology:DOID:0050567); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); colon adenoma (Disease Ontology:DOID:0050912); colorectal carcinoma (Disease Ontology:DOID:0080199); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); colon carcinoma (Disease Ontology:DOID:1520); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); transient cerebral ischemia (Disease Ontology:DOID:224); craniosynostosis (Disease Ontology:DOID:2340); endometrial adenocarcinoma (Disease Ontology:DOID:2870); gallbladder cancer (Disease Ontology:DOID:3121); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (rno:29134); (R-RNO-201681); (R-RNO-4641257); (R-RNO-5689880)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9566905", "class_list": "", "function": "Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0045600 positive regulation of fat cell differentiation;GO:0048255 mRNA stabilization;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O70240-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25235-1", "uniprot_id": "RPN2_RAT", "mass": 69078.0, "length": 631, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "gene_name": "Rpn2", "organism": "Rat", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 precursor", "refseq_ac": "NP_113886", "gene_names_uniprotkb": "Rpn2", "gene_names_refseq": "Rpn2", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit; RPN-II; Ribophorin II; Ribophorin-2", "protein_names_refseq": "RPN-II; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 precursor; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; ribophorin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:64701); (R-RNO-9768727); (R-RNO-9931295)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15240697;1710116;34502162;38843836", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9X0", "ec_number_list": "", "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005783 endoplasmic reticulum;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A;GO:0160227 oligosaccharyltransferase complex B", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P25235-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZTD8-1", "uniprot_id": "SEM5A_RAT", "mass": 120378.0, "length": 1074, "protein_name": "Semaphorin-5A", "gene_name": "Sema5a", "organism": "Rat", "refseq_name": "semaphorin-5A precursor", "refseq_ac": "NP_001101129", "gene_names_uniprotkb": "Sema5a", "gene_names_refseq": "Sema5a", "protein_names_uniprotkb": "Semaphorin-5A; Sema F; Semaphorin-F", "protein_names_refseq": "sema F; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; semaphorin-5A precursor; semaphorin-F", "tax_id": 10116, "disease": "", "pathway": " (rno:310207); (R-RNO-416700); (R-RNO-5173214)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15603739;16144627;20696765", "class_list": "", "function": "Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Semaphorin5A expression in the developing chick telencephalon., [RefSeq, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0045499 chemorepellent activity;GO:0045545 syndecan binding;GO:0035373 chondroitin sulfate proteoglycan binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0097485 neuron projection guidance;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0021536 diencephalon development;GO:1990256 signal clustering;GO:0007162 negative regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZTD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70418-1", "uniprot_id": "RN112_RAT", "mass": 68646.0, "length": 631, "protein_name": "RING finger protein 112", "gene_name": "Rnf112", "organism": "Rat", "refseq_name": "RING finger protein 112 isoform 1", "refseq_ac": "NP_619516", "gene_names_uniprotkb": "Rnf112; Bfp; Zfp179; Znf179", "gene_names_refseq": "BFP; Bfb; Rnf112; Zfp179; Znf179", "protein_names_uniprotkb": "RING finger protein 112; 2.3.2.27; Brain finger protein; Zinc finger protein 179", "protein_names_refseq": "RING finger protein 112 isoform 1; brain finger protein; zinc finger protein 179", "tax_id": 10116, "disease": "", "pathway": " (rno:24916)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26212327;9367872", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Identify neurolastin as a dynamin family GTPase that affects endosome size and spine density., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0014069 postsynaptic density", "go_biological_process": "GO:0045687 positive regulation of glial cell differentiation;GO:0045666 positive regulation of neuron differentiation;GO:0051260 protein homooligomerization;GO:0030182 neuron differentiation;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70418-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25031-1", "uniprot_id": "REG3B_RAT", "mass": 19617.0, "length": 175, "protein_name": "Regenerating islet-derived protein 3-beta", "gene_name": "Reg3b", "organism": "Rat", "refseq_name": "regenerating islet-derived protein 3-beta precursor", "refseq_ac": "NP_445741", "gene_names_uniprotkb": "Reg3b; Pap1; Pap; Reg2", "gene_names_refseq": "Pap1; Pap; Reg3b", "protein_names_uniprotkb": "Regenerating islet-derived protein 3-beta; Pancreatitis-associated protein 1; Peptide 23; REG-2; REG-3-beta; Reg III-beta; Regenerating islet-derived protein III-beta", "protein_names_refseq": "Pancreatitis-associated protein 1; REG-2; REG-3-beta; pancreatic beta cell growth factor; peptide 23; reg III-beta; regenerating islet-derived 3 beta; regenerating islet-derived protein 3-beta precursor; regenerating islet-derived protein 3-beta; regenerating islet-derived protein III-beta", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); sciatic neuropathy (Disease Ontology:DOID:11446); acute pancreatitis (Disease Ontology:DOID:2913); liver cirrhosis (Disease Ontology:DOID:5082); borna disease (Disease Ontology:DOID:5154); pneumonia (Disease Ontology:DOID:552); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24618); (R-RNO-6803157)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "1511905;1722211;24587207;25751817;29305881;31744864;32084646;7895644;8238345;8314803", "class_list": "", "function": "Acts as a hormone in response to different stimuli. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. In pancreas, is able stimulate cell proliferation., [UniProtKB, UniProtKB]; After peripheral nerve injury, PAP-I can be transported to the spinal dorsal horn and is crucial in the progression of neuropathic pain Erratum:[J Neurosci. 2020 Mar 11;40(11):2381. doi: 10.1523/JNEUROSCI.0064-20.2020. PMID: 32086257], [RefSeq, PubMed]; Bactericidal C-type lectin which acts against several intestinal Gram-positive bacteria and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues., [UniProtKB, UniProtKB]; Reg3beta-dependent accumulation of macrophages in the ischemic heart has a role in myocardial healing, [RefSeq, PubMed]; Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats Publication Status: Online-Only, [RefSeq, PubMed]; These results demonstrate a direct effect of INGAP-PP on the liver acting through P-Akt signaling pathway. INGAP-PP enhances liver glucose metabolism and deposit and reduces its production/output, thereby contributing to maintain normal glucose homeostasis., [RefSeq, PubMed]; We used cerulein-induced pancreatic acinar cells to investigate the significance of PAP-1 up-regulation in acute pancreatitis and discovered that PAP-1 may function to prevent apoptosis in response to reactive oxygen species-induced NF-kappaB signaling in pancreatic acinar cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64102;Q64231", "ec_number_list": "", "go_molecular_function": "GO:0019838 growth factor binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005615 extracellular space;GO:0045177 apical part of cell;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0001934 positive regulation of protein phosphorylation;GO:0008284 positive regulation of cell population proliferation;GO:0042594 response to starvation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P25031-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70600-1", "uniprot_id": "RSAD2_RAT", "mass": 41255.0, "length": 360, "protein_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2", "gene_name": "Rsad2", "organism": "Rat", "refseq_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2", "refseq_ac": "NP_620236", "gene_names_uniprotkb": "Rsad2; Best5", "gene_names_refseq": "Best5; Rsad2; SAND; Vig1", "protein_names_uniprotkb": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; 4.2.-.-; Bone-expressed sequence tag 5 protein; Radical S-adenosyl methionine domain-containing protein 2; SAND; Viperin; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible", "protein_names_refseq": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; bone-expressed sequence tag 5 protein; radical S-adenosyl methionine domain-containing protein 2; viperin; virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible", "tax_id": 10116, "disease": "respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273)", "pathway": " (rno:65190)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10698968", "class_list": "", "function": "Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses. Also promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.-.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016829 lyase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0035710 CD4-positive, alpha-beta T cell activation;GO:0050709 negative regulation of protein secretion;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O70600-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24049-1", "uniprot_id": "RL17_RAT", "mass": 21397.0, "length": 184, "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "LOC120100542; Rpl17l3; Rpl17", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL22", "refseq_ac": "NP_958818", "gene_names_uniprotkb": "LOC120100542; Rpl17l3; Rpl17; LOC120100647; LOC120102453; LOC134486536; LOC499522; Rpl17l5; Rpl17", "gene_names_refseq": "ASI; Rpl17; rpL23", "protein_names_uniprotkb": "Large ribosomal subunit protein uL22; 60S ribosomal protein L17; ASI; Amino acid starvation-induced protein; L23", "protein_names_refseq": "60S ribosomal protein L17; L23; amino acid starvation-induced protein; large ribosomal subunit protein uL22", "tax_id": 10116, "disease": "", "pathway": " (rno:120100542); (rno:291434); (rno:499522); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 4, "publication_id_list": "1894596;2069571;2211664;38843836", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G093", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:1990928 response to amino acid starvation;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0034198 cellular response to amino acid starvation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P24049-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2C0-1", "uniprot_id": "RM22_RAT", "mass": 24039.0, "length": 206, "protein_name": "Large ribosomal subunit protein uL22m", "gene_name": "Mrpl22", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL22m precursor", "refseq_ac": "NP_001099251", "gene_names_uniprotkb": "Mrpl22", "gene_names_refseq": "Mrpl22", "protein_names_uniprotkb": "Large ribosomal subunit protein uL22m; 39S ribosomal protein L22, mitochondrial; L22mt; MRP-L22", "protein_names_refseq": "39S ribosomal protein L22, mitochondrial; L22mt; MRP-L22; large ribosomal subunit protein uL22m precursor; large ribosomal subunit protein uL22m", "tax_id": 10116, "disease": "", "pathway": " (rno:287302); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9857009", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C2C0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1WBT0-1", "uniprot_id": "TM232_RAT", "mass": 71914.0, "length": 617, "protein_name": "Transmembrane protein 232", "gene_name": "Tmem232", "organism": "Rat", "refseq_name": "transmembrane protein 232", "refseq_ac": "NP_001257319", "gene_names_uniprotkb": "Tmem232", "gene_names_refseq": "RGD1559548; Tmem232", "protein_names_uniprotkb": "Transmembrane protein 232", "protein_names_refseq": "transmembrane protein 232", "tax_id": 10116, "disease": "", "pathway": " (rno:501199)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a critical role for male fertility and sperm motility by regulating sperm cytoplasm removal and maintaining axoneme integrity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0030030 cell projection organization;GO:0098544 maintenance of protein complex location;GO:0160087 spermatid cytoplasm removal during spermiation of flagellated sperm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WBT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2C1-1", "uniprot_id": "RM30_RAT", "mass": 18412.0, "length": 160, "protein_name": "Large ribosomal subunit protein uL30m", "gene_name": "Mrpl30", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL30m precursor", "refseq_ac": "NP_001100373", "gene_names_uniprotkb": "Mrpl30; NEWGENE_1308196", "gene_names_refseq": "Mrpl30", "protein_names_uniprotkb": "Large ribosomal subunit protein uL30m; 39S ribosomal protein L30, mitochondrial; L30mt; MRP-L30", "protein_names_refseq": "39S ribosomal protein L30, mitochondrial-like; 39S ribosomal protein L30, mitochondrial; L30mt; MRP-L30; large ribosomal subunit protein uL30m precursor; large ribosomal subunit protein uL30m", "tax_id": 10116, "disease": "", "pathway": " (rno:301352); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9857009", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C2C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21531-1", "uniprot_id": "RL3_RAT", "mass": 46136.0, "length": 403, "protein_name": "Large ribosomal subunit protein uL3", "gene_name": "Rpl3", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL3", "refseq_ac": "NP_942048", "gene_names_uniprotkb": "Rpl3", "gene_names_refseq": "Rpl3", "protein_names_uniprotkb": "Large ribosomal subunit protein uL3; 60S ribosomal protein L3; L4", "protein_names_refseq": "60S ribosomal protein L3; L4; large ribosomal subunit protein uL3", "tax_id": 10116, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479)", "pathway": " (rno:300079); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "1520347;6355773", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008097 5S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0005840 ribosome", "go_biological_process": "GO:0006412 translation;GO:0071353 cellular response to interleukin-4;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P21531-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0JPP4-1", "uniprot_id": "SPESP_RAT", "mass": 45880.0, "length": 409, "protein_name": "Sperm equatorial segment protein 1", "gene_name": "Spesp1", "organism": "Rat", "refseq_name": "sperm equatorial segment protein 1 precursor", "refseq_ac": "NP_001071150", "gene_names_uniprotkb": "Spesp1", "gene_names_refseq": "RGD1563468; Spesp1", "protein_names_uniprotkb": "Sperm equatorial segment protein 1", "protein_names_refseq": "sperm equatorial segment protein 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:501010)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in fertilization ability of sperm., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0009566 fertilization;GO:0007340 acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JPP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0JPP5-1", "uniprot_id": "TEX47_RAT", "mass": 29601.0, "length": 253, "protein_name": "Testis-expressed protein 47", "gene_name": "Tex47", "organism": "Rat", "refseq_name": "testis-expressed protein 47", "refseq_ac": "NP_001071149", "gene_names_uniprotkb": "Tex47", "gene_names_refseq": "RGD1564345; Tex47", "protein_names_uniprotkb": "Testis-expressed protein 47", "protein_names_refseq": "testis-expressed protein 47; uncharacterized protein C7orf62 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:499993)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JPP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1L134-1", "uniprot_id": "AUP1_RAT", "mass": 46199.0, "length": 410, "protein_name": "Lipid droplet-regulating VLDL assembly factor AUP1", "gene_name": "Aup1", "organism": "Rat", "refseq_name": "lipid droplet-regulating VLDL assembly factor AUP1", "refseq_ac": "NP_001073368", "gene_names_uniprotkb": "Aup1", "gene_names_refseq": "Aup1", "protein_names_uniprotkb": "Lipid droplet-regulating VLDL assembly factor AUP1; Ancient ubiquitous protein 1", "protein_names_refseq": "ancient ubiquitous protein 1; lipid droplet-regulating VLDL assembly factor AUP1", "tax_id": 10116, "disease": "", "pathway": " (rno:680423)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity). Plays a role in lipid droplet formation (By similarity). Induces lipid droplet clustering (By similarity). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (By similarity). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (By similarity). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0031624 ubiquitin conjugating enzyme binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0005776 autophagosome", "go_biological_process": "GO:0009615 response to virus;GO:0036503 ERAD pathway;GO:0034389 lipid droplet organization;GO:0140042 lipid droplet formation;GO:0030970 retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L134-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2RRU3-1", "uniprot_id": "UTP15_RAT", "mass": 59515.0, "length": 528, "protein_name": "U3 small nucleolar RNA-associated protein 15 homolog", "gene_name": "Utp15", "organism": "Rat", "refseq_name": "U3 small nucleolar RNA-associated protein 15 homolog", "refseq_ac": "NP_001101117", "gene_names_uniprotkb": "Utp15", "gene_names_refseq": "RGD1310992; Utp15", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 15 homolog", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 15 homolog; UTP15 SSU processome component; UTP15, U3 small nucleolar ribonucleoprotein, homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:310019); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0032040 small-subunit processome", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0006364 rRNA processing;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2RRU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2RRU4-1", "uniprot_id": "SCAP_RAT", "mass": 139499.0, "length": 1276, "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "gene_name": "Scap", "organism": "Rat", "refseq_name": "sterol regulatory element-binding protein cleavage-activating protein", "refseq_ac": "NP_001094436", "gene_names_uniprotkb": "Scap", "gene_names_refseq": "Scap", "protein_names_uniprotkb": "Sterol regulatory element-binding protein cleavage-activating protein; SCAP; SREBP cleavage-activating protein", "protein_names_refseq": "SREBP cleavage activating protein; sterol regulatory element-binding protein cleavage-activating protein", "tax_id": 10116, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:301024); (R-RNO-1655829)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19158095", "class_list": "", "function": "Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity). Binds cholesterol via its SSD domain (By similarity)., [UniProtKB, UniProtKB]; Insulin selectively stimulates the processing of SREBP-1c in rat hepatocytes by enhancing the association between the SCAP-SREBP-1c complex and COPII proteins and subsequent ER to Golgi transport and proteolytic cleavage., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0032934 sterol binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0032991 protein-containing complex;GO:0032936 SREBP-SCAP complex", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006629 lipid metabolic process;GO:0006955 immune response;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2RRU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A4F267-1", "uniprot_id": "TM40L_RAT", "mass": 34049.0, "length": 308, "protein_name": "Mitochondrial import receptor subunit TOM40B", "gene_name": "Nr1i3; Tomm40l", "organism": "Rat", "refseq_name": "mitochondrial import receptor subunit TOM40B", "refseq_ac": "NP_001076807", "gene_names_uniprotkb": "Nr1i3; Tomm40l; Tomm40b; Tomm40l", "gene_names_refseq": "RGD1562006; Tomm40b; Tomm40l", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM40B; Protein TOMM40-like", "protein_names_refseq": "mitochondrial import receptor subunit TOM40B; translocase of outer mitochondrial membrane 40 homolog B; translocase of outer mitochondrial membrane 40 homolog-like", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); cholestasis (Disease Ontology:DOID:13580)", "pathway": " (rno:304971)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17437969", "class_list": "", "function": "Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element., [UniProtKB, UniProtKB]; Potential channel-forming protein implicated in import of protein precursors into mitochondria., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070678 preprotein binding;GO:0008320 protein transmembrane transporter activity;GO:0030943 mitochondrion targeting sequence binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0032991 protein-containing complex;GO:0005742 mitochondrial outer membrane translocase complex;GO:0005741 mitochondrial outer membrane;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030150 protein import into mitochondrial matrix;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4F267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7XYI6-1", "uniprot_id": "SOBP_RAT", "mass": 91771.0, "length": 864, "protein_name": "Sine oculis-binding protein homolog", "gene_name": "Sobp", "organism": "Rat", "refseq_name": "sine oculis-binding protein homolog", "refseq_ac": "NP_001098110", "gene_names_uniprotkb": "Sobp; Jxc1", "gene_names_refseq": "RGD1560479; Sobpl; Sobp; jcx1", "protein_names_uniprotkb": "Sine oculis-binding protein homolog; Jackson circler protein 1", "protein_names_refseq": "jackson circler protein 1; sine oculis-binding protein homolog-like; sine oculis-binding protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:309860)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Implicated in development of the cochlea., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032184 SUMO polymer binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007626 locomotory behavior;GO:0042472 inner ear morphogenesis;GO:0050890 cognition;GO:0007605 sensory perception of sound;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7XYI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BN49-1", "uniprot_id": "RBMX2_RAT", "mass": 37829.0, "length": 328, "protein_name": "RNA-binding motif protein, X-linked 2", "gene_name": "Rbmx2", "organism": "Rat", "refseq_name": "RNA-binding motif protein, X-linked 2", "refseq_ac": "NP_001107258", "gene_names_uniprotkb": "Rbmx2", "gene_names_refseq": "RGD1562693; Rbmx2", "protein_names_uniprotkb": "RNA-binding motif protein, X-linked 2", "protein_names_refseq": "RNA-binding motif protein, X-linked 2", "tax_id": 10116, "disease": "", "pathway": " (rno:367930); (R-RNO-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031965 nuclear membrane;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BN49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BN56-1", "uniprot_id": "RT31_RAT", "mass": 43962.0, "length": 387, "protein_name": "Small ribosomal subunit protein mS31", "gene_name": "Mrps31", "organism": "Rat", "refseq_name": "small ribosomal subunit protein mS31", "refseq_ac": "NP_001099561", "gene_names_uniprotkb": "Mrps31", "gene_names_refseq": "MRP-S31; Mrps31; S31mt", "protein_names_uniprotkb": "Small ribosomal subunit protein mS31; 28S ribosomal protein S31, mitochondrial; MRP-S31; S31mt", "protein_names_refseq": "28S ribosomal protein S31, mitochondrial; small ribosomal subunit protein mS31", "tax_id": 10116, "disease": "", "pathway": " (rno:290850); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BN56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BNK8-1", "uniprot_id": "TET5B_RAT", "mass": 47016.0, "length": 427, "protein_name": "Terminal nucleotidyltransferase 5B", "gene_name": "Tent5b", "organism": "Rat", "refseq_name": "terminal nucleotidyltransferase 5B", "refseq_ac": "NP_001101377", "gene_names_uniprotkb": "Tent5b; AABR07033236.1; Fam46b", "gene_names_refseq": "Fam46b; RGD1308967; Tent5b", "protein_names_uniprotkb": "Terminal nucleotidyltransferase 5B; 2.7.7.19; Non-canonical poly(A) polymerase FAM46B", "protein_names_refseq": "Protein FAM46B; family with sequence similarity 46, member B; non-canonical poly(A) polymerase FAM46B; putative nucleotidyltransferase FAM46B; terminal nucleotidyltransferase 5B", "tax_id": 10116, "disease": "", "pathway": " (rno:313019)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner. May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs. Prefers RNA molecules that are adenosine-rich close to 3'-end. In addition, may inhibit cell proliferation and cell cycle progression through ubiquitination of beta-catenin/CTNNB1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.19;2.7.7.52", "go_molecular_function": "GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0048255 mRNA stabilization;GO:0045727 positive regulation of translation;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1WBM3-1", "uniprot_id": "TM138_RAT", "mass": 19266.0, "length": 162, "protein_name": "Transmembrane protein 138", "gene_name": "Tmem138", "organism": "Rat", "refseq_name": "transmembrane protein 138", "refseq_ac": "NP_942072", "gene_names_uniprotkb": "Tmem138", "gene_names_refseq": "Tmem138", "protein_names_uniprotkb": "Transmembrane protein 138", "protein_names_refseq": "transmembrane protein 138", "tax_id": 10116, "disease": "", "pathway": " (rno:361728)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Required for ciliogenesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1WBM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2GUZ5-1", "uniprot_id": "CAZA1_RAT", "mass": 32910.0, "length": 286, "protein_name": "F-actin-capping protein subunit alpha-1", "gene_name": "Capza1", "organism": "Rat", "refseq_name": "F-actin-capping protein subunit alpha-1", "refseq_ac": "NP_001103095", "gene_names_uniprotkb": "Capza1", "gene_names_refseq": "Capza1", "protein_names_uniprotkb": "F-actin-capping protein subunit alpha-1; CapZ alpha-1", "protein_names_refseq": "F-actin capping protein alpha-1 subunit; F-actin-capping protein subunit alpha-1; capZ alpha-1; capping actin protein of muscle Z-line alpha subunit 1; capping protein (actin filament) muscle Z-line, alpha 1", "tax_id": 10116, "disease": "", "pathway": " (rno:691149); (R-RNO-879415)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18556119;19343716;19452629;21752999;22673903", "class_list": "", "function": "Data show that as a consequence of RhoA knockdown, F-actin levels were significantly reduced in PC12 cells., [RefSeq, PubMed]; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These findings indicate that capping of actin filaments by capping protein represents an essential step for the remodeling of the actin architecture underlying spine morphogenesis and synaptic formation during development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005903 brush border;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0008290 F-actin capping protein complex", "go_biological_process": "GO:0034329 cell junction assembly;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B2GUZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2GV05-1", "uniprot_id": "RBM5_RAT", "mass": 92352.0, "length": 815, "protein_name": "RNA-binding protein 5", "gene_name": "Rbm5", "organism": "Rat", "refseq_name": "RNA-binding protein 5 isoform 1", "refseq_ac": "NP_001094018", "gene_names_uniprotkb": "Rbm5", "gene_names_refseq": "Rbm5", "protein_names_uniprotkb": "RNA-binding protein 5; RNA-binding motif protein 5", "protein_names_refseq": "RNA-binding protein 5 isoform 1; RNA-binding protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:300996); (R-RNO-9770562)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22673903;24178303;25578565;28818525;29393594", "class_list": "", "function": "Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (By similarity). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Findings indicate that RBM5 promotes neuronal apoptosis through modulating p53 signaling pathway following SCI., [RefSeq, PubMed]; RBM5 regulates Rab4a in rat neurons, [RefSeq, PubMed]; This work establishes myoblast differentiation as a relevant model in which to conduct functional studies regarding Rbm5 and Rbm10., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B2GV05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2GV47-1", "uniprot_id": "RADX_RAT", "mass": 96287.0, "length": 844, "protein_name": "RPA-related protein RADX", "gene_name": "Radx", "organism": "Rat", "refseq_name": "RPA-related protein RADX", "refseq_ac": "NP_001120849", "gene_names_uniprotkb": "Radx", "gene_names_refseq": "Radx", "protein_names_uniprotkb": "RPA-related protein RADX", "protein_names_refseq": "RPA-related protein RADX; uncharacterized protein CXorf57 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:680663)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005657 replication fork", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GV47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RZ39-1", "uniprot_id": "RM36_RAT", "mass": 10801.0, "length": 97, "protein_name": "Large ribosomal subunit protein bL36m", "gene_name": "Mrpl36", "organism": "Rat", "refseq_name": "large ribosomal subunit protein bL36m", "refseq_ac": "NP_001102349", "gene_names_uniprotkb": "Mrpl36", "gene_names_refseq": "Mrpl36", "protein_names_uniprotkb": "Large ribosomal subunit protein bL36m; 39S ribosomal protein L36, mitochondrial; L36mt; MRP-L36", "protein_names_refseq": "39S ribosomal protein L36, mitochondrial-like; 39S ribosomal protein L36, mitochondrial; L36mt; MRP-L36; large ribosomal subunit protein bL36m", "tax_id": 10116, "disease": "", "pathway": " (rno:364656); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RZ39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RZD2-1", "uniprot_id": "T126B_RAT", "mass": 25213.0, "length": 229, "protein_name": "Complex I assembly factor TMEM126B, mitochondrial", "gene_name": "Tmem126b", "organism": "Rat", "refseq_name": "complex I assembly factor TMEM126B, mitochondrial", "refseq_ac": "NP_001099750", "gene_names_uniprotkb": "Tmem126b", "gene_names_refseq": "RGD1308371; Tmem126b", "protein_names_uniprotkb": "Complex I assembly factor TMEM126B, mitochondrial; Transmembrane protein 126B", "protein_names_refseq": "complex I assembly factor TMEM126B, mitochondrial", "tax_id": 10116, "disease": "nuclear type mitochondrial complex I deficiency 29 (Disease Ontology:DOID:0112084)", "pathway": " (rno:293114); (R-RNO-6799198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22982022", "class_list": "", "function": "As part of the MCIA complex, involved in the assembly of the mitochondrial complex I (PubMed:22982022). Participates in constructing the membrane arm of complex I (By similarity)., [UniProtKB, UniProtKB, PubMed]; TMEM126B as a previously overlooked component of the mitochondrial complex I assembly factor (MCIA) complex and show that this protein is indeed required for the formation of respiratory chain complex I., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V8Z8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0160295 mitochondrial complex I intermediate assembly complex", "go_biological_process": "GO:0032094 response to food;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RZD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5DEI4-1", "uniprot_id": "UBE2W_RAT", "mass": 17331.0, "length": 151, "protein_name": "Ubiquitin-conjugating enzyme E2 W", "gene_name": "Ube2w", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 W", "refseq_ac": "NP_001388217", "gene_names_uniprotkb": "Ube2w", "gene_names_refseq": "Ube2w", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 W; 2.3.2.23; 2.3.2.25; E2 ubiquitin-conjugating enzyme W; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; Ubiquitin carrier protein W; Ubiquitin-protein ligase W", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme W; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; ubiquitin carrier protein W; ubiquitin-conjugating enzyme E2 W-like; ubiquitin-conjugating enzyme E2 W; ubiquitin-protein ligase W", "tax_id": 10116, "disease": "", "pathway": " (rno:100909445); (R-RNO-8866652); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination also occurs in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.32;2.3.2.31;2.3.2.23;2.3.2.27;2.3.2.34;2.3.2.24;2.3.2.-;2.3.2.25;6.2.1.45;6.2.1.64", "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0000209 protein polyubiquitination;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DEI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5MEV3-1", "uniprot_id": "S52A2_RAT", "mass": 46956.0, "length": 450, "protein_name": "Solute carrier family 52, riboflavin transporter, member 2", "gene_name": "Slc52a2", "organism": "Rat", "refseq_name": "solute carrier family 52, riboflavin transporter, member 2", "refseq_ac": "NP_001103140", "gene_names_uniprotkb": "Slc52a2; Gpr172a; Gpr172b; Rft1", "gene_names_refseq": "Gpr172a; Gpr172b; RGD1560410; Slc52a2; rRFT1", "protein_names_uniprotkb": "Solute carrier family 52, riboflavin transporter, member 2; Porcine endogenous retrovirus A receptor 2; Protein GPR172B; Riboflavin transporter 1; rRFT1", "protein_names_refseq": "G protein-coupled receptor 172A; G protein-coupled receptor 172B; porcine endogenous retrovirus A receptor 2; riboflavin transporter 1; solute carrier family 52, riboflavin transporter, member 2", "tax_id": 10116, "disease": "Brown-Vialetto-Van Laere syndrome (Disease Ontology:DOID:0050694); Brown-Vialetto-Van Laere syndrome 2 (Disease Ontology:DOID:0080786); riboflavin deficiency (Disease Ontology:DOID:8454)", "pathway": " (rno:362942); (R-RNO-196843)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18632736;19122205;23413253;27964953;31601465", "class_list": "", "function": "Identification/characterization riboflavin trasporter (RFT1) as a novel riboflavin transporter., [RefSeq, PubMed]; Intestinal riboflavin uptake process undergoes differentiation-dependent upregulation and suggest that this is mediated (at least in part) via transcriptional mechanisms of SLC52A1 and SLC52A3., [RefSeq, PubMed]; Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. May also act as a receptor for 4-hydroxybutyrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The function and inhibition profile suggested the involvement of riboflavin transporter 2 in riboflavin transport at the inner BRB, and this is supported by expression and knockdown analysis of rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3) in TR-iBRB2 cells., [RefSeq, PubMed]; The obtained results suggested the involvement of riboflavin transporters (SLC52A/RFVT) at the outer BRB, and this is supported by the expression and knockdown analyses of rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3)., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KN99", "ec_number_list": "", "go_molecular_function": "GO:0032217 riboflavin transmembrane transporter activity;GO:0062124 4-hydroxybutyrate receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032218 riboflavin transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B5MEV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B6CZ62-1", "uniprot_id": "TOMT_RAT", "mass": 28864.0, "length": 258, "protein_name": "Transmembrane O-methyltransferase homolog", "gene_name": "Tomt", "organism": "Rat", "refseq_name": "transmembrane O-methyltransferase homolog", "refseq_ac": "NP_001132966", "gene_names_uniprotkb": "Tomt; Comt2", "gene_names_refseq": "Lrtomt; RGD1561509; Tomt", "protein_names_uniprotkb": "Transmembrane O-methyltransferase homolog; 2.1.1.6; Catechol O-methyltransferase 2", "protein_names_refseq": "O-methyltransferase domain containing; catechol O-methyltransferase 2; leucine rich transmembrane and 0-methyltransferase domain containing; leucine rich transmembrane and O-methyltransferase domain containing; protein LRTOMT2; transmembrane O-methyltransferase homolog", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 63 (Disease Ontology:DOID:0110515)", "pathway": " (rno:308868); (R-RNO-379397)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18953341", "class_list": "", "function": "Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (By similarity). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.6", "go_molecular_function": "GO:0016206 catechol O-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0045177 apical part of cell", "go_biological_process": "GO:1904591 positive regulation of protein import;GO:0032502 developmental process;GO:0007605 sensory perception of sound;GO:0042417 dopamine metabolic process;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B6CZ62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B7SBD2-1", "uniprot_id": "TOX3_RAT", "mass": 63503.0, "length": 577, "protein_name": "TOX high mobility group box family member 3", "gene_name": "Tox3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tox3; Tnrc9", "gene_names_refseq": "", "protein_names_uniprotkb": "TOX high mobility group box family member 3; Trinucleotide repeat-containing gene 9 protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:291908)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19196971", "class_list": "", "function": "Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0042803 protein homodimerization activity;GO:0051219 phosphoprotein binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0019722 calcium-mediated signaling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B7SBD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z987-1", "uniprot_id": "RBM44_RAT", "mass": 113582.0, "length": 1020, "protein_name": "RNA-binding protein 44", "gene_name": "Rbm44", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rbm44", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA-binding protein 44; RNA-binding motif protein 44", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:501183)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003730 mRNA 3'-UTR binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045171 intercellular bridge;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z987-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZBM4-1", "uniprot_id": "RN182_RAT", "mass": 27546.0, "length": 247, "protein_name": "E3 ubiquitin-protein ligase RNF182", "gene_name": "Rnf182", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF182", "refseq_ac": "NP_001102587", "gene_names_uniprotkb": "Rnf182", "gene_names_refseq": "RGD1560399; Rnf182", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF182; 2.3.2.27; RING finger protein 182; RING-type E3 ubiquitin transferase RNF182", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF182; RING-type E3 ubiquitin transferase RNF182", "tax_id": 10116, "disease": "", "pathway": " (rno:498726); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.32;2.3.2.31;2.3.2.23;2.3.2.27;2.3.2.34;2.3.2.24;2.3.2.-;2.3.2.25", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZBM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZF92-1", "uniprot_id": "TNR21_RAT", "mass": 71870.0, "length": 655, "protein_name": "Tumor necrosis factor receptor superfamily member 21", "gene_name": "Tnfrsf21", "organism": "Rat", "refseq_name": "tumor necrosis factor receptor superfamily member 21 precursor", "refseq_ac": "NP_001101677", "gene_names_uniprotkb": "Tnfrsf21; Dr6", "gene_names_refseq": "Tnfrsf21", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 21; Death receptor 6", "protein_names_refseq": "death receptor 6; tumor necrosis factor receptor superfamily member 21 precursor; tumor necrosis factor receptor superfamily, member 21", "tax_id": 10116, "disease": "", "pathway": " (rno:316256)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21725297;26244598", "class_list": "", "function": "Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B (By similarity). Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm (By similarity). Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP) (By similarity). Negatively regulates oligodendrocyte survival, maturation and myelination (PubMed:21725297). Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation (By similarity). Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells (By similarity). Negatively regulates the production of IgG, IgM and IgM in response to antigens (By similarity). May inhibit the activation of JNK in response to T-cell stimulation (By similarity). Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (By similarity)., [UniProtKB, PubMed, UniProtKB]; The results demonstrated that miR-210 decreased inflammation in articular cavity in OA rats by targeting DR6 and inhibiting NF-kappaB signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032693 negative regulation of interleukin-10 production;GO:0032714 negative regulation of interleukin-5 production;GO:0051402 neuron apoptotic process;GO:0006915 apoptotic process;GO:0042130 negative regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZF92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZG27-1", "uniprot_id": "UBIA1_RAT", "mass": 37026.0, "length": 338, "protein_name": "UbiA prenyltransferase domain-containing protein 1", "gene_name": "Ubiad1", "organism": "Rat", "refseq_name": "ubiA prenyltransferase domain-containing protein 1", "refseq_ac": "NP_001101463", "gene_names_uniprotkb": "Ubiad1", "gene_names_refseq": "RGD1309588; Ubiad1", "protein_names_uniprotkb": "UbiA prenyltransferase domain-containing protein 1; 2.5.1.-; 2.5.1.39", "protein_names_refseq": "ubiA prenyltransferase domain-containing protein 1", "tax_id": 10116, "disease": "lymphoma (Disease Ontology:DOID:0060058); Schnyder corneal dystrophy (Disease Ontology:DOID:0060456)", "pathway": " (rno:313706); (R-RNO-6806664)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "27846632;30483777", "class_list": "", "function": "In a rat model of chronic kidney disease, there was a decrease in the thoracic aorta expression of Vkor and Ggcx enzymes, and a decrease in the kidney level of vitamin K1 to MK-4 bioconversion enzyme Ubiad1., [RefSeq, PubMed]; Low Ubiad1 expression is associated with cardiac hypertrophy in spontaneously hypertensive rats., [RefSeq, PubMed]; Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.-;2.5.1.39", "go_molecular_function": "GO:0016209 antioxidant activity;GO:0004659 prenyltransferase activity;GO:0008412 4-hydroxybenzoate polyprenyltransferase activity;GO:0120566 menadiol geranylgeranyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0072359 circulatory system development;GO:0006744 ubiquinone biosynthetic process;GO:0009234 menaquinone biosynthetic process;GO:0042371 vitamin K biosynthetic process;GO:0001885 endothelial cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZG27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZUC4-1", "uniprot_id": "AUNIP_RAT", "mass": 38244.0, "length": 347, "protein_name": "Aurora kinase A- and ninein-interacting protein", "gene_name": "Aunip", "organism": "Rat", "refseq_name": "aurora kinase A- and ninein-interacting protein", "refseq_ac": "NP_001386265", "gene_names_uniprotkb": "Aunip", "gene_names_refseq": "Aunip", "protein_names_uniprotkb": "Aurora kinase A- and ninein-interacting protein", "protein_names_refseq": "Aurora kinase A and ninein-interacting protein; aurora kinase A- and ninein-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:689656)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0090734 site of DNA damage", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0007051 spindle organization;GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZUC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZUC6-1", "uniprot_id": "TOPZ1_RAT", "mass": 184593.0, "length": 1646, "protein_name": "Protein TOPAZ1", "gene_name": "Topaz1", "organism": "Rat", "refseq_name": "protein TOPAZ1 isoform X3", "refseq_ac": "XP_063121377", "gene_names_uniprotkb": "Topaz1", "gene_names_refseq": "RGD1563398; Topaz1", "protein_names_uniprotkb": "Protein TOPAZ1; Testis- and ovary-specific PAZ domain-containing protein 1", "protein_names_refseq": "protein TOPAZ1 isoform X3", "tax_id": 10116, "disease": "", "pathway": " (rno:301075)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "R9PXW9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030154 cell differentiation;GO:0006915 apoptotic process;GO:0048137 spermatocyte division;GO:0140742 lncRNA transcription;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZUC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02765-1", "uniprot_id": "CATS_RAT", "mass": 36833.0, "length": 330, "protein_name": "Cathepsin S", "gene_name": "Ctss", "organism": "Rat", "refseq_name": "cathepsin S preproprotein", "refseq_ac": "NP_059016", "gene_names_uniprotkb": "Ctss", "gene_names_refseq": "Ctss", "protein_names_uniprotkb": "Cathepsin S; 3.4.22.27", "protein_names_refseq": "cathepsin S preproprotein", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); COVID-19 (Disease Ontology:DOID:0080600); Raynaud disease (Disease Ontology:DOID:10300); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); intracranial aneurysm (Disease Ontology:DOID:10941); sarcoidosis (Disease Ontology:DOID:11335); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); Down syndrome (Disease Ontology:DOID:14250); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); carotid artery disease (Disease Ontology:DOID:3407); neuropathy (Disease Ontology:DOID:870); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:50654); (R-RNO-1474228); (R-RNO-1679131); (R-RNO-2022090); (R-RNO-2132295); (R-RNO-6798695); (R-RNO-9766229); (R-RNO-9958810)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "1281481;37347150;37946211", "class_list": "", "function": "M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast-Schwann cell-signaling relay. Publication Status: Online-Only, [RefSeq, PubMed]; Spinal Cathepsin S promotes visceral hypersensitivity via FKN/CX3CR1/p38 MAPK signaling pathways., [RefSeq, PubMed]; Thiol protease (By similarity). Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). Elicits itch by mediating cleavage and activation of MRGPRX1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.4;2.3.2.27;3.4.22.42;3.4.16.-;5.2.1.8;1.1.1.205;3.4.24.7;3.2.1.23;3.5.4.5;2.3.2.5;3.6.4.13;2.4.1.25;3.2.1.33;4.2.99.18;5.6.2.4;4.1.2.4;2.4.1.186;3.5.4.6;3.4.22.38;3.1.1.47;3.4.24.34;3.2.1.17;3.4.22.1;3.4.24.17;1.11.1.6;2.5.1.18;4.1.2.13;3.6.5.-;4.2.1.24;3.2.1.31;3.4.22.15;2.4.1.1;2.7.10.2;2.7.11.1;2.7.1.40;1.13.11.-;1.13.11.34;3.4.19.1;3.4.23.34;2.3.3.8;1.16.3.1;2.7.4.6;2.7.13.3;3.4.24.-;3.4.23.5;5.4.2.11;5.4.2.4;2.7.1.1;3.3.2.6;3.4.11.4;2.7.1.11;5.3.2.1;5.3.3.12;3.4.21.46;5.4.2.2;1.1.1.42;3.6.4.6;3.4.24.23;3.4.24.35;3.1.6.12;2.3.2.26;3.6.4.10;2.7.11.24;3.4.14.1;3.1.3.48;2.4.2.1;3.4.22.52;3.4.22.27;3.5.1.3;3.4.19.9;3.4.24.65;1.8.3.2;5.3.1.9;5.1.3.-;3.5.1.23;3.5.1.-;3.6.1.6;3.4.25.1;3.4.22.34;3.4.18.1;1.11.1.24", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005518 collagen binding;GO:0043236 laminin binding;GO:0008233 peptidase activity;GO:0043394 proteoglycan binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002250 adaptive immune response;GO:0050729 positive regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02765-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A280-1", "uniprot_id": "PAK5_RAT", "mass": 80949.0, "length": 718, "protein_name": "Serine/threonine-protein kinase PAK 5", "gene_name": "Pak5", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase PAK 5", "refseq_ac": "NP_001101251", "gene_names_uniprotkb": "Pak5; Pak7", "gene_names_refseq": "PAK-5; PAK-7; Pak5; Pak7", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK 5; 2.7.11.1; PAK-5; PAK-7; p21-activated kinase 5; p21-activated kinase 7", "protein_names_refseq": "p21 (CDKN1A)-activated kinase 7; p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; serine/threonine-protein kinase PAK 5; serine/threonine-protein kinase PAK 7", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:311450); (R-RNO-9013149); (R-RNO-9013407)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16014608;22673903", "class_list": "", "function": "Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.10.2;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.3.1.-;2.7.11.34;2.7.10.1;2.7.1.150;2.7.11.13;4.1.1.32;3.6.5.2;2.7.11.19;2.7.2.3;2.7.11.11;2.7.10.4;3.6.4.6;2.7.11.31;3.1.3.16;3.1.4.4;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;1.6.3.-;3.6.5.-;2.4.99.18;2.7.11.10;2.1.1.13", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0007626 locomotory behavior;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A280-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A5U3-1", "uniprot_id": "TGM3_RAT", "mass": 77230.0, "length": 693, "protein_name": "Protein-glutamine gamma-glutamyltransferase E", "gene_name": "Tgm3", "organism": "Rat", "refseq_name": "protein-glutamine gamma-glutamyltransferase E", "refseq_ac": "NP_001102429", "gene_names_uniprotkb": "Tgm3; Tgase3", "gene_names_refseq": "RGD1561831; TG(E); TGE; Tgm3", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase E; 2.3.2.13; TG(E); TGE; TGase E; TGase-3; Transglutaminase E; Transglutaminase-3", "protein_names_refseq": "TGase E; TGase-3; glutamine gamma-glutamyltransferase E; protein-glutamine gamma-glutamyltransferase E; transglutaminase 3, E polypeptide; transglutaminase E", "tax_id": 10116, "disease": "", "pathway": " (rno:366189)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.13;3.4.-.-;2.3.1.-;3.5.1.44", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0005509 calcium ion binding;GO:0003824 catalytic activity;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0031424 keratinization;GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A5U3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A615-1", "uniprot_id": "TONSL_RAT", "mass": 151834.0, "length": 1367, "protein_name": "Tonsoku-like protein", "gene_name": "Tonsl", "organism": "Rat", "refseq_name": "tonsoku-like protein", "refseq_ac": "NP_001124044", "gene_names_uniprotkb": "Tonsl; Ikbr; Nfkbil2", "gene_names_refseq": "Nfkbil2; Tonsl", "protein_names_uniprotkb": "Tonsoku-like protein; I-kappa-B-related protein; IkappaBR; Inhibitor of kappa B-related protein; NF-kappa-B inhibitor-like protein 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2", "protein_names_refseq": "I-kappa-B-related protein; NF-kappa-B inhibitor-like protein 2; ikappaBR; inhibitor of kappa B-related protein; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2; tonsoku-like protein", "tax_id": 10116, "disease": "spondyloepimetaphyseal dysplasia, Sponastrime type (Disease Ontology:DOID:5684)", "pathway": " (rno:366953)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones. Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0035861 site of double-strand break", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing;GO:0071168 protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A615-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A723-1", "uniprot_id": "RN152_RAT", "mass": 22356.0, "length": 203, "protein_name": "E3 ubiquitin-protein ligase RNF152", "gene_name": "Rnf152", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF152", "refseq_ac": "NP_001099775", "gene_names_uniprotkb": "Rnf152", "gene_names_refseq": "Rnf152", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF152; 2.3.2.27; RING finger protein 152; RING-type E3 ubiquitin transferase RNF152", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF152; RING-type E3 ubiquitin transferase RNF152", "tax_id": 10116, "disease": "", "pathway": " (rno:293561); (R-RNO-8866654)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;3.6.5.-;2.3.2.23", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031267 small GTPase binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0010508 positive regulation of autophagy;GO:0070936 protein K48-linked ubiquitination;GO:0034198 cellular response to amino acid starvation;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A723-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ACN8-1", "uniprot_id": "PLRKT_RAT", "mass": 17312.0, "length": 147, "protein_name": "Plasminogen receptor (KT)", "gene_name": "Plgrkt", "organism": "Rat", "refseq_name": "plasminogen receptor (KT)", "refseq_ac": "NP_001099817", "gene_names_uniprotkb": "Plgrkt", "gene_names_refseq": "Plg-R(KT); Plgrkt; RGD1306839", "protein_names_uniprotkb": "Plasminogen receptor (KT); Plg-R(KT)", "protein_names_refseq": "plasminogen receptor (KT); plasminogen receptor, C-terminal lysine transmembrane protein", "tax_id": 10116, "disease": "", "pathway": " (rno:293888)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21795689", "class_list": "", "function": "Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9 (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0006935 chemotaxis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4ACN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AE41-1", "uniprot_id": "RMXL1_RAT", "mass": 42250.0, "length": 388, "protein_name": "RNA binding motif protein, X-linked-like-1", "gene_name": "Rbmxl1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rbmxl1", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA binding motif protein, X-linked-like-1; Heterogeneous nuclear ribonucleoprotein G-like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA-binding protein which may be involved in pre-mRNA splicing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0006376 mRNA splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AE41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54888-1", "uniprot_id": "RPA2_RAT", "mass": 127721.0, "length": 1135, "protein_name": "DNA-directed RNA polymerase I subunit RPA2", "gene_name": "Polr1b", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerase I subunit RPA2", "refseq_ac": "NP_113961", "gene_names_uniprotkb": "Polr1b; Rpa2; Rpo1-2", "gene_names_refseq": "Polr1b; RPA2; Rpo1-2", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA2; 2.7.7.6; A127; RNA polymerase I subunit 2; RPA135", "protein_names_refseq": "A127; DNA-directed RNA polymerase I subunit RPA2; RNA polymerase 1-2; RNA polymerase I (127 kDa subunit); RNA polymerase I polypeptide B; RNA polymerase I subunit 2; RPA135; polymerase (RNA) I polypeptide B; polymerase (RNA) I subunit B", "tax_id": 10116, "disease": "Treacher Collins syndrome 4 (Disease Ontology:DOID:0080792); Treacher Collins syndrome (Disease Ontology:DOID:2908)", "pathway": " (rno:83582); (R-RNO-5250924); (R-RNO-73762); (R-RNO-73772); (R-RNO-73863)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "9422795", "class_list": "", "function": "Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene clusters, giving rise to 5.8S, 18S and 28S ribosomal RNAs (By similarity) (PubMed:9422795). Pol I-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol I pre-initiation complex (PIC) is recruited by the selectivity factor 1 (SL1/TIF-IB) complex bound to the core promoter that precedes an rDNA repeat unit. The PIC assembly bends the promoter favoring the formation of the transcription bubble and promoter escape. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Highly processive, assembles in structures referred to as 'Miller trees' where many elongating Pol I complexes queue and transcribe the same rDNA coding regions. At terminator sequences downstream of the rDNA gene, PTRF interacts with Pol I and halts Pol I transcription leading to the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:9422795). Forms Pol I active center together with the largest subunit POLR1A/RPA1. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR1A/RPA1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR1B/RPA2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and the template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. Has proofreading activity: Pauses and backtracks to allow the cleavage of a missincorporated nucleotide via POLR1H/RPA12. High Pol I processivity is associated with decreased transcription fidelity (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48;2.7.7.6;5.6.2.3;2.7.10.2;2.7.11.1;2.7.11.26;2.7.11.22;2.7.11.23;2.7.11.24;3.6.4.-;3.6.4.13;5.6.2.4", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0032549 ribonucleoside binding;GO:0003899 DNA-directed RNA polymerase activity;GO:0071667 DNA/RNA hybrid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0005694 chromosome;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0014029 neural crest formation;GO:0017126 nucleologenesis;GO:0009303 rRNA transcription;GO:0007566 embryo implantation;GO:0006362 transcription elongation by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O54888-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09367-1", "uniprot_id": "SDHL_RAT", "mass": 38433.0, "length": 363, "protein_name": "L-serine dehydratase/L-threonine deaminase", "gene_name": "Sds", "organism": "Rat", "refseq_name": "L-serine dehydratase/L-threonine deaminase", "refseq_ac": "NP_446414", "gene_names_uniprotkb": "Sds", "gene_names_refseq": "RATSDHE1; SDH2; Sdhe1; Sdh; Sds; TDH", "protein_names_uniprotkb": "L-serine dehydratase/L-threonine deaminase; 4.3.1.17; 4.3.1.19; L-serine deaminase; L-threonine dehydratase; SDH; TDH", "protein_names_refseq": "L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase", "tax_id": 10116, "disease": "", "pathway": " (rno:25044); (R-RNO-8849175); (R-RNO-977347)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11906824;14596599;15618015;163593;17928680;2228554;2228555;23087176;2660911;3205731;3391277;3413060;7581747", "class_list": "", "function": "Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats, [RefSeq, PubMed]; Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Excess leucine intake induces Sdh in rat liver., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M8C4", "ec_number_list": "4.3.1.17;4.3.1.19;5.1.1.3;4.3.1.18;5.1.1.18", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0003941 L-serine ammonia-lyase activity;GO:0004794 threonine deaminase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0006629 lipid metabolic process;GO:0031667 response to nutrient levels;GO:0006094 gluconeogenesis;GO:0043200 response to amino acid", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P09367-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88869-1", "uniprot_id": "RASF9_RAT", "mass": 49545.0, "length": 435, "protein_name": "Ras association domain-containing protein 9", "gene_name": "Rassf9", "organism": "Rat", "refseq_name": "ras association domain-containing protein 9", "refseq_ac": "NP_075248", "gene_names_uniprotkb": "Rassf9; Pamci; Pcip1", "gene_names_refseq": "P-cip1; Pamci; Rassf9", "protein_names_uniprotkb": "Ras association domain-containing protein 9; P-CIP1; PAM COOH-terminal interactor protein 1; Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor", "protein_names_refseq": "PAM COOH-terminal interactor protein 1; Ras association (RalGDS/AF-6) domain family (N-terminal) member 9; peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor; ras association domain-containing protein 9", "tax_id": 10116, "disease": "", "pathway": " (rno:65053)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9837933", "class_list": "", "function": "May play a role in regulating vesicuar trafficking in cells., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0012510 trans-Golgi network transport vesicle membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0055037 recycling endosome", "go_biological_process": "GO:0007165 signal transduction;GO:0006605 protein targeting;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88869-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LU71-1", "uniprot_id": "AUHM_RAT", "mass": 33341.0, "length": 315, "protein_name": "Methylglutaconyl-CoA hydratase, mitochondrial", "gene_name": "Auh", "organism": "Rat", "refseq_name": "methylglutaconyl-CoA hydratase, mitochondrial", "refseq_ac": "NP_001386179", "gene_names_uniprotkb": "Auh", "gene_names_refseq": "Auh", "protein_names_uniprotkb": "Methylglutaconyl-CoA hydratase, mitochondrial; 3-MG-CoA hydratase; 4.2.1.18; 4.2.1.56; AU-binding enoyl-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase; Itaconyl-CoA hydratase", "protein_names_refseq": "3-MG-CoA hydratase; AU RNA binding protein/enoyl-CoA hydratase; AU RNA binding protein/enoyl-coenzyme A hydratase; AU-binding enoyl-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase; itaconyl-CoA hydratase; methylglutaconyl-CoA hydratase, mitochondrial", "tax_id": 10116, "disease": "3-methylglutaconic aciduria type 1 (Disease Ontology:DOID:0110002); renal tubular transport disease (Disease Ontology:DOID:447)", "pathway": " (rno:361215); (R-RNO-70895)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "13783048", "class_list": "", "function": "Catalyzes the fifth step in the leucine degradation pathway, the reversible hydration of 3-methylglutaconyl-CoA (3-MG-CoA) to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Can catalyze the reverse reaction but at a much lower rate in vitro. HMG-CoA is then quickly degraded by another enzyme (such as HMG-CoA lyase) to give acetyl-CoA and acetoacetate. Uses other substrates such as (2E)-glutaconyl-CoA efficiently in vitro, and to a lesser extent 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA), crotonyl-CoA ((2E)-butenoyl-CoA) and 3-hydroxybutanoyl-CoA (the missing carboxylate reduces affinity to the active site). Originally it was identified as an RNA-binding protein as it binds to AU-rich elements (AREs) in vitro. AREs direct rapid RNA degradation and mRNA deadenylation (By similarity). Might have itaconyl-CoA hydratase activity, converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, an antimicrobial metabolite and immunomodulator produced by macrophages during certain infections, that can act as a vitamin B12-poisoning metabolite (PubMed:13783048)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.18;4.2.1.56;4.2.1.17;5.3.3.8", "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0004300 enoyl-CoA hydratase activity;GO:0004490 methylglutaconyl-CoA hydratase activity;GO:0050011 itaconyl-CoA hydratase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006552 L-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LU71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06300-1", "uniprot_id": "PDYN_RAT", "mass": 28079.0, "length": 248, "protein_name": "Proenkephalin-B", "gene_name": "Pdyn", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pdyn", "gene_names_refseq": "", "protein_names_uniprotkb": "Proenkephalin-B; Beta-neoendorphin-dynorphin; Dyn-B; Dynorphin B(1-13); Dynorphin B-29; Dynorphin B; Preprodynorphin", "protein_names_refseq": "", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); spinocerebellar ataxia 23 (Disease Ontology:DOID:0050973); withdrawal disorder (Disease Ontology:DOID:0060001); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); opioid abuse (Disease Ontology:DOID:11206); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); temporal lobe epilepsy (Disease Ontology:DOID:3328); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29190); (R-RNO-111885); (R-RNO-202040); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "16181412;2628741;2862869;2874472;2893267;3858883;8276115", "class_list": "", "function": "Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin., [UniProtKB, UniProtKB, UniProtKB]; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress., [UniProtKB, UniProtKB, UniProtKB]; Leumorphin has a typical opioid activity and may have anti-apoptotic effect., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63193", "ec_number_list": "", "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0035094 response to nicotine;GO:0045471 response to ethanol;GO:0007268 chemical synaptic transmission;GO:0007600 sensory perception", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P06300-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70199-1", "uniprot_id": "UGDH_RAT", "mass": 54892.0, "length": 493, "protein_name": "UDP-glucose 6-dehydrogenase", "gene_name": "Ugdh", "organism": "Rat", "refseq_name": "UDP-glucose 6-dehydrogenase", "refseq_ac": "NP_112615", "gene_names_uniprotkb": "Ugdh", "gene_names_refseq": "Ugdh", "protein_names_uniprotkb": "UDP-glucose 6-dehydrogenase; 1.1.1.22; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH", "protein_names_refseq": "UDP-Glc dehydrogenase; UDP-GlcDH; UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogeanse; UDP-glucose dehydrogenase; UDPGDH", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 84 (Disease Ontology:DOID:0112219)", "pathway": " (rno:83472); (R-RNO-173599)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans. Required for proper brain and neuronal development., [UniProtKB, UniProtKB]; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.22", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0003979 UDP-glucose 6-dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001702 gastrulation with mouth forming second;GO:0006024 glycosaminoglycan biosynthetic process;GO:0048666 neuron development;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O70199-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88583-1", "uniprot_id": "SOCS3_RAT", "mass": 24808.0, "length": 225, "protein_name": "Suppressor of cytokine signaling 3", "gene_name": "Socs3", "organism": "Rat", "refseq_name": "suppressor of cytokine signaling 3", "refseq_ac": "NP_446017", "gene_names_uniprotkb": "Socs3; Cish3", "gene_names_refseq": "Cish3; Socs-3; Socs3; Ssi-3", "protein_names_uniprotkb": "Suppressor of cytokine signaling 3; Cytokine-inducible SH2 protein 3; SOCS-3", "protein_names_refseq": "cytokine inducible SH2-containing protein 3; cytokine-inducible SH2 protein 3; suppressor of cytokine signaling 3", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); status epilepticus (Disease Ontology:DOID:1824); invasive ductal carcinoma (Disease Ontology:DOID:3008); cholangiocarcinoma (Disease Ontology:DOID:4947); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:89829); (R-RNO-1059683); (R-RNO-877300); (R-RNO-877312); (R-RNO-8849474); (R-RNO-8951664); (R-RNO-909733); (R-RNO-9705462); (R-RNO-983168)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "10579313;11108838;33522063;35702948;36793115;37154979;37856074", "class_list": "", "function": "Cinnamaldehyde and hesperetin attenuate TNBS-induced ulcerative colitis in rats through modulation of the JAk2/STAT3/SOCS3 pathway., [RefSeq, PubMed]; MiR-218-5p-dependent SOCS3 downregulation increases osteoblast differentiation inpostmenopausal osteoporosis. Publication Status: Online-Only, [RefSeq, PubMed]; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SOCS3 Silencing Promotes Activation of Vocal Fold Fibroblasts via JAK2/STAT3 Signaling Pathway., [RefSeq, PubMed]; Silencing suppressor of cytokine signaling 3 induces apoptosis and activates the p-STAT3/NF-kappaB pathway in hypoxic cultivated H9c2 cells., [RefSeq, PubMed]; Unraveling the role of Epac1-SOCS3 signaling in the development of neonatal-CRD-induced visceral hypersensitivity in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYV5", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004860 protein kinase inhibitor activity;GO:0035198 miRNA binding;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0010332 response to gamma radiation;GO:0032496 response to lipopolysaccharide;GO:0035556 intracellular signal transduction;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88583-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10536-1", "uniprot_id": "RAB1B_RAT", "mass": 22163.0, "length": 201, "protein_name": "Ras-related protein Rab-1B", "gene_name": "Rab1b", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rab1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras-related protein Rab-1B; 3.6.5.2", "protein_names_refseq": "", "tax_id": 10116, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:100126191); (R-RNO-162658); (R-RNO-204005); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "1648736;1918138;23188820;2493636;2509243;34502162", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (PubMed:1918138). Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (PubMed:23188820)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;5.6.1.3;3.6.5.5;3.6.1.5;3.4.14.1;2.7.11.26;2.5.1.60;2.3.1.-;3.6.1.-;2.7.11.21;3.6.5.4;3.4.18.1", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:1903020 positive regulation of glycoprotein metabolic process;GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10536-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12749-1", "uniprot_id": "RL26_RAT", "mass": 17277.0, "length": 145, "protein_name": "Large ribosomal subunit protein uL24", "gene_name": "Rpl26", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rpl26", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein uL24; 60S ribosomal protein L26", "protein_names_refseq": "", "tax_id": 10116, "disease": "Diamond-Blackfan anemia 11 (Disease Ontology:DOID:0111892)", "pathway": " (rno:287417); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "2546830", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0048027 mRNA 5'-UTR binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0043195 terminal bouton;GO:0045202 synapse", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:1990928 response to amino acid starvation;GO:0045727 positive regulation of translation;GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P12749-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70536-1", "uniprot_id": "SOAT1_RAT", "mass": 64146.0, "length": 545, "protein_name": "Sterol O-acyltransferase 1", "gene_name": "Soat1", "organism": "Rat", "refseq_name": "sterol O-acyltransferase 1", "refseq_ac": "NP_112380", "gene_names_uniprotkb": "Soat1; Acact; Acat", "gene_names_refseq": "Acat-1; Soat1", "protein_names_uniprotkb": "Sterol O-acyltransferase 1; 2.3.1.26; ACAT-1; Acyl-coenzyme A:cholesterol acyltransferase 1; Cholesterol acyltransferase 1", "protein_names_refseq": "acyl-coenzyme A:cholesterol acyltransferase 1; cholesterol acyltransferase 1; sterol O-acyltransferase 1", "tax_id": 10116, "disease": "Chagas disease (Disease Ontology:DOID:12140)", "pathway": " (rno:81782); (R-RNO-8964038)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9555010", "class_list": "", "function": "Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.26", "go_molecular_function": "GO:0042802 identical protein binding;GO:0015485 cholesterol binding;GO:0000062 fatty-acyl-CoA binding;GO:0004772 sterol O-acyltransferase activity;GO:0034736 cholesterol O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010742 macrophage derived foam cell differentiation;GO:0008203 cholesterol metabolic process;GO:0033344 cholesterol efflux;GO:0034379 very-low-density lipoprotein particle assembly;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O70536-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01174-1", "uniprot_id": "WAP_RAT", "mass": 14827.0, "length": 137, "protein_name": "Whey acidic protein", "gene_name": "Wap", "organism": "Rat", "refseq_name": "whey acidic protein precursor", "refseq_ac": "NP_446203", "gene_names_uniprotkb": "Wap", "gene_names_refseq": "Wap", "protein_names_uniprotkb": "Whey acidic protein; WAP; Whey phosphoprotein", "protein_names_refseq": "whey acidic protein precursor; whey phosphoprotein", "tax_id": 10116, "disease": "", "pathway": " (rno:114596)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15652158;6095207;6896749;6955785", "class_list": "", "function": "Could be a protease inhibitor., [UniProtKB]; There are two conserved regions highly similar to hypersensitive sites present in mouse and rabbit upstream region of WAP gene with binding sites for STAT5 transcription factor, essential for expression of WAP gene in mammary glands during lactation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01174-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54889-1", "uniprot_id": "RPA1_RAT", "mass": 194192.0, "length": 1716, "protein_name": "DNA-directed RNA polymerase I subunit RPA1", "gene_name": "Polr1a", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerase I subunit RPA1", "refseq_ac": "NP_113960", "gene_names_uniprotkb": "Polr1a; Rpa1; Rpo1-4", "gene_names_refseq": "Polr1a; Rpa1; Rpo1-4", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA1; 2.7.7.6; A194; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; RNA polymerase I 194 kDa subunit; RNA polymerase I subunit A1; RPA194", "protein_names_refseq": "A194; DNA-directed RNA polymerase I A; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; DNA-directed RNA polymerase I subunit RPA1; RNA polymerase 1-4; RNA polymerase I 194 kDa subunit; RNA polymerase I subunit A1; RPA194; polymerase (RNA) I polypeptide A; polymerase (RNA) I subunit A", "tax_id": 10116, "disease": "acrofacial dysostosis Cincinnati type (Disease Ontology:DOID:0060353); hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786)", "pathway": " (rno:83581); (R-RNO-5250924); (R-RNO-73762); (R-RNO-73772); (R-RNO-73863)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "9422795", "class_list": "", "function": "Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene clusters, giving rise to 5.8S, 18S and 28S ribosomal RNAs (By similarity). Pol I-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol I pre-initiation complex (PIC) is recruited by the selectivity factor 1 (SL1/TIF-IB) complex bound to the core promoter that precedes an rDNA repeat unit. The PIC assembly bends the promoter favoring the formation of the transcription bubble and promoter escape. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Highly processive, assembles in structures referred to as 'Miller trees' where many elongating Pol I complexes queue and transcribe the same rDNA coding regions. At terminator sequences downstream of the rDNA gene, PTRF interacts with Pol I and halts Pol I transcription leading to the release of the RNA transcript and polymerase from the DNA (By similarity). Forms Pol I active center together with the second largest subunit POLR1B/RPA2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR1A/RPA1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR1B/RPA2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and the template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. Has proofreading activity: Pauses and backtracks to allow the cleavage of a missincorporated nucleotide via POLR1H/RPA12. High Pol I processivity is associated with decreased transcription fidelity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48;2.7.7.6;5.6.2.3;2.7.10.2;2.7.11.1;2.7.11.26;2.7.11.22;2.7.11.23;2.7.11.24;3.6.4.-;3.6.4.13;5.6.2.4", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0001650 fibrillar center;GO:0000785 chromatin;GO:0005694 chromosome;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:1904750 negative regulation of protein localization to nucleolus;GO:0009303 rRNA transcription;GO:0006362 transcription elongation by RNA polymerase I;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O54889-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08701-1", "uniprot_id": "ARGI2_RAT", "mass": 38640.0, "length": 354, "protein_name": "Arginase-2, mitochondrial", "gene_name": "Arg2", "organism": "Rat", "refseq_name": "arginase-2, mitochondrial precursor", "refseq_ac": "NP_062041", "gene_names_uniprotkb": "Arg2", "gene_names_refseq": "Arg2", "protein_names_uniprotkb": "Arginase-2, mitochondrial; 3.5.3.1; Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase", "protein_names_refseq": "AII type II arginase; arginase II; arginase type II; arginase-2, mitochondrial precursor; arginase-2, mitochondrial; kidney-type arginase; non-hepatic arginase; type II arginase", "tax_id": 10116, "disease": "retinitis pigmentosa 45 (Disease Ontology:DOID:0110402); retinitis pigmentosa (Disease Ontology:DOID:10584); hypertension (Disease Ontology:DOID:10763); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); ureteral obstruction (Disease Ontology:DOID:5199); end stage renal disease (Disease Ontology:DOID:783); hyperargininemia (Disease Ontology:DOID:9278)", "pathway": " (rno:29215); (R-RNO-70635); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "29627571;39236462;8898077;9608538", "class_list": "", "function": "Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway., [RefSeq, PubMed]; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity., [UniProtKB, UniProtKB, UniProtKB]; The present results indicate that Advanced glycation endproducts impairs endothelial-dependent vasodilation, and this effect is mediated via arginase overexpression and NADPH oxidase stimulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97539", "ec_number_list": "6.1.1.5;1.3.8.5;6.2.1.4;4.98.1.1;5.6.2.3;2.8.3.5;2.3.1.-;2.3.1.41;3.4.21.92;3.5.3.1;3.1.2.2;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.2.-;1.1.1.37;6.4.1.3;7.1.2.2;1.4.1.3;1.2.1.3;2.3.1.37;4.2.1.2;2.3.1.9;2.3.3.10;5.3.3.8;1.1.1.30;3.6.4.10;1.2.4.1;1.1.1.42;5.6.1.7;1.3.8.1;3.5.3.-;3.5.3.17;3.5.3.7;2.7.1.23;1.2.4.2;5.3.3.21;2.7.11.2;2.7.11.-;7.1.1.2;1.2.1.36;1.7.1.-;1.2.1.28;1.8.1.4;2.3.3.1;3.4.21.53;1.1.1.41;4.2.1.3", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0050998 nitric-oxide synthase binding;GO:0004053 arginase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032700 negative regulation of interleukin-17 production;GO:0032651 regulation of interleukin-1 beta production;GO:0007584 response to nutrient;GO:0001666 response to hypoxia;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08701-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18665-1", "uniprot_id": "RM03_RAT", "mass": 38253.0, "length": 347, "protein_name": "Large ribosomal subunit protein uL3m", "gene_name": "Mrpl3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mrpl3; Mrl3; Rpml3", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein uL3m; 39S ribosomal protein L3, mitochondrial; L3mt; MRP-L3", "protein_names_refseq": "", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 9 (Disease Ontology:DOID:0111472)", "pathway": " (rno:300974); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "2891103", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18665-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55081-1", "uniprot_id": "RBL2_RAT", "mass": 127818.0, "length": 1135, "protein_name": "Retinoblastoma-like protein 2", "gene_name": "Rbl2", "organism": "Rat", "refseq_name": "retinoblastoma-like protein 2", "refseq_ac": "NP_112356", "gene_names_uniprotkb": "Rbl2", "gene_names_refseq": "Rb2; Rbl2", "protein_names_uniprotkb": "Retinoblastoma-like protein 2; 130 kDa retinoblastoma-associated protein; PPAR-alpha-interacting complex protein 128; PRIC128; RBR-2; Retinoblastoma-related protein 2; p130; pRb2", "protein_names_refseq": "130 kDa retinoblastoma-associated protein; P130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RBR-2; retinoblastoma-like 2; retinoblastoma-like protein 2; retinoblastoma-related protein 2", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); thrombosis (Disease Ontology:DOID:0060903); Brunet-Wagner neurodevelopmental syndrome (Disease Ontology:DOID:0061126); myeloid neoplasm (Disease Ontology:DOID:0070004); COVID-19 (Disease Ontology:DOID:0080600); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); preterm premature rupture of the membranes (Disease Ontology:DOID:0111144); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); von Willebrand's disease (Disease Ontology:DOID:12531); cancer (Disease Ontology:DOID:162); acute pancreatitis (Disease Ontology:DOID:2913); carotid artery thrombosis (Disease Ontology:DOID:3410); bile duct disease (Disease Ontology:DOID:4138); liver cirrhosis (Disease Ontology:DOID:5082); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:81758); (R-RNO-1538133); (R-RNO-69231)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12189208;15174090;18818403;19099372;22673903;9247086;9697699", "class_list": "", "function": "Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; PPARalpha trans-repression involved the recruitment of the retinoblastoma (RB) family proteins p107 and p130 to the TERT promoter resulting in impaired E2F-1 binding, an effect that was dependent on p16., [RefSeq, PubMed]; RB2/P130 could be a marker of senescence or that it even plays a role in triggering the process in MSCs., [RefSeq, PubMed]; Rb2 was found to have a role in neural differentiation but not in neural determination., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:1990841 promoter-specific chromatin binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O55081-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08426-1", "uniprot_id": "TRY3_RAT", "mass": 26269.0, "length": 247, "protein_name": "Cationic trypsin-3", "gene_name": "Prss3b; Try3", "organism": "Rat", "refseq_name": "cationic trypsin-3 precursor", "refseq_ac": "NP_775150", "gene_names_uniprotkb": "Prss3b; Try3; Prss3", "gene_names_refseq": "Prss3b; Prss3; Try3", "protein_names_uniprotkb": "Cationic trypsin-3; 3.4.21.4; Cationic trypsin III; Pretrypsinogen III", "protein_names_refseq": "cationic trypsin III; cationic trypsin-3 precursor; cationic trypsin-3; cationic trypsinogen; pretrypsinogen III; protease, serine, 3", "tax_id": 10116, "disease": "pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (rno:286911)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16036133;18278461;3607011;9419241", "class_list": "", "function": "Expression of trypsin and R122H trypsinogen induced caspase-3 activity. Acinar cells might react to intracellular trypsin activity by triggering apoptosis., [RefSeq, PubMed]; NF-kappa B activation is likely not necessary for high concentrations of carbachol-induced trypsinogen activation in pancreatic acinar cells in vitro, [RefSeq, PubMed]; This trypsinogen is typical of non-human gnathostomata trypinsogens; it has 6 predicted cystine bridges and an acidic activation peptide. It clusters with group II ('cationic') trypsins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P08426-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V8H4-1", "uniprot_id": "CBLC_RAT", "mass": 55775.0, "length": 497, "protein_name": "E3 ubiquitin-protein ligase CBL-C", "gene_name": "Cblc", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase CBL-C", "refseq_ac": "NP_001030092", "gene_names_uniprotkb": "Cblc; Cbl-3", "gene_names_refseq": "Cblc", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CBL-C; 2.3.2.27; RING-type E3 ubiquitin transferase CBL-C", "protein_names_refseq": "Cas-Br-M (murine) ecotropic retroviral transforming sequence c; Casitas B-lineage lymphoma c; Cbl proto-oncogene C, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase C; E3 ubiquitin-protein ligase CBL-C; RING-type E3 ubiquitin transferase CBL-C", "tax_id": 10116, "disease": "", "pathway": " (rno:292699)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18753381", "class_list": "", "function": "Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival., [UniProtKB, PubMed]; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KRC9", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0005509 calcium ion binding;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0043524 negative regulation of neuron apoptotic process;GO:0050821 protein stabilization;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V8H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15693-1", "uniprot_id": "PPBI1_RAT", "mass": 58402.0, "length": 540, "protein_name": "Intestinal-type alkaline phosphatase 1", "gene_name": "Alpi", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Alpi", "gene_names_refseq": "", "protein_names_uniprotkb": "Intestinal-type alkaline phosphatase 1; 3.1.3.1; IAP-1; IAP-I; Intestinal alkaline phosphatase 1; Intestinal alkaline phosphatase I", "protein_names_refseq": "", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (rno:24197); (R-RNO-1483166); (R-RNO-163125); (R-RNO-6811438); (R-RNO-8935690)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "2155025;24076154;7744844", "class_list": "", "function": "Alkaline phosphatase that can hydrolyze various phosphate compounds., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.31;3.1.3.2;3.1.3.1;3.1.3.48;3.9.1.1;3.1.3.5;3.6.5.2;3.5.1.92;3.2.2.6;3.1.4.50;3.4.11.9", "go_molecular_function": "GO:0004035 alkaline phosphatase activity;GO:0000287 magnesium ion binding;GO:0002020 protease binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0016311 dephosphorylation;GO:0071773 cellular response to BMP stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P15693-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V9R3-1", "uniprot_id": "ST1D1_RAT", "mass": 35004.0, "length": 295, "protein_name": "Sulfotransferase 1 family member D1", "gene_name": "Sult1d1", "organism": "Rat", "refseq_name": "sulfotransferase 1 family member D1", "refseq_ac": "NP_068537", "gene_names_uniprotkb": "Sult1d1", "gene_names_refseq": "ST1D1; Sult-n; Sult1d1; Sultn", "protein_names_uniprotkb": "Sulfotransferase 1 family member D1; 2.8.2.-; Dopamine sulfotransferase Sult1d1; ST1D1; Tyrosine-ester sulfotransferase", "protein_names_refseq": "N-sulfotransferase; dopamine sulfotransferase Sult1d1; sulfotransferase 1 family member D1; tyrosine-ester sulfotransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:60393)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sulfotransferase with broad substrate specificity that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, such as dopamine, prostaglandins, leukotriene E4, drugs and xenobiotic compounds. Has sulfotransferase activity towards p-nitrophenol, 2-naphthylamine and minoxidil (in vitro). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1G0", "ec_number_list": "", "go_molecular_function": "GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051923 sulfation;GO:0006629 lipid metabolic process;GO:0006584 catecholamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V9R3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08564-1", "uniprot_id": "PLPP1_RAT", "mass": 31996.0, "length": 282, "protein_name": "Phospholipid phosphatase 1", "gene_name": "Plpp1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Plpp1; Lpp1; Ppap2a", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipid phosphatase 1; 3.1.3.-; 3.1.3.106; 3.1.3.4; 3.6.1.75; Lipid phosphate phosphohydrolase 1; PAP-2a; PAP2-alpha; PAP2a; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-9845614)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10359651;11704545;17057224;8663293", "class_list": "", "function": "Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:10359651, PubMed:8663293). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10359651). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (By similarity). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (By similarity). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (PubMed:17057224)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K594", "ec_number_list": "3.1.3.4;3.6.1.75;3.1.3.2;3.1.3.-;3.1.3.106;3.1.3.5;3.1.3.48;3.3.2.10;3.1.3.76;3.6.1.-;3.6.1.68", "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0008195 phosphatidate phosphatase activity;GO:0042577 lipid phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0106235 ceramide-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045121 membrane raft;GO:0016324 apical plasma membrane;GO:0005901 caveola", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0007165 signal transduction;GO:0009395 phospholipid catabolic process;GO:0006672 ceramide metabolic process;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08564-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R7X9-1", "uniprot_id": "TAFA5_RAT", "mass": 14331.0, "length": 132, "protein_name": "Chemokine-like protein TAFA-5", "gene_name": "Tafa5", "organism": "Rat", "refseq_name": "chemokine-like protein TAFA-5 precursor", "refseq_ac": "NP_001178920", "gene_names_uniprotkb": "Tafa5; Fam19a5", "gene_names_refseq": "Fam19a5; RGD1562115; Tafa-5; Tafa5", "protein_names_uniprotkb": "Chemokine-like protein TAFA-5", "protein_names_refseq": "chemokine-like protein TAFA-5 precursor; chemokine-like protein TAFA-5; family with sequence similarity 19 (chemokine (C-C motif)-like), member A5; family with sequence similarity 19 member A5, C-C motif chemokine like; protein FAM19A5", "tax_id": 10116, "disease": "", "pathway": " (rno:500915)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18275939;29453251", "class_list": "", "function": "Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (PubMed:29453251). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (PubMed:29453251). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (PubMed:29453251)., [UniProtKB, PubMed, UniProtKB]; Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling., [RefSeq, PubMed]; We found TAFA5 mRNA to be highly expressed in the hypothalamic paraventricular nucleus (PVN) where it co-localized with vasopressin and oxytocin in magno- and parvocellular neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0061044 negative regulation of vascular wound healing;GO:0007186 G protein-coupled receptor signaling pathway;GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation;GO:1904753 negative regulation of vascular associated smooth muscle cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "M0R7X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R8L2-1", "uniprot_id": "SPXN_RAT", "mass": 13083.0, "length": 116, "protein_name": "Spexin", "gene_name": "SPX", "organism": "Rat", "refseq_name": "spexin precursor", "refseq_ac": "NP_001077402", "gene_names_uniprotkb": "SPX", "gene_names_refseq": "Npq; Spx", "protein_names_uniprotkb": "Spexin; Liver regeneration-related protein LRRGT00060; NPQ 53-70; NPQ; Neuropeptide Q; Spexin hormone", "protein_names_refseq": "LRRGT00060; liver regeneration-related protein LRRGT00060; neuropeptide Q; spexin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:691138)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19132080;20045034;20530460;22038051;23080164;24550067;31396649;33632048;33928538", "class_list": "", "function": "Acts as a ligand for galanin receptors GALR2 and GALR3 (By similarity). Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes. Also induces contraction of muscarinic-like stomach smooth muscles (PubMed:24550067)., [UniProtKB, PubMed]; Effect of spexin on renal dysfunction in experimentally obese rats: potential mitigating mechanisms via galanin receptor-2., [RefSeq, PubMed]; Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (PubMed:22038051)., [UniProtKB, PubMed]; Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem., [RefSeq, PubMed]; Newly identified peptides derived from the NPQ/spexin precursor contribute to CNS-mediated control of arterial blood pressure and salt and water balance and modulate nociceptive responses, [RefSeq, PubMed]; Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (PubMed:20045034, PubMed:22038051)., [UniProtKB, PubMed, PubMed]; Results suggest direct involvement of spexin in the regulation of adrenocortical cell proliferation; however, the mechanism of action remains unknown., [RefSeq, PubMed]; Spexin is a novel hormone involved in weight regulation, with potential for obesity therapy., [RefSeq, PubMed]; Spexin is probably involved in many different physiological functions; in particular, location of spexin in neurons and endocrine cells suggests its roles as neurotransmitter/neuromodulator and endocrine factor., [RefSeq, PubMed]; Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6TXE0", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031765 type 2 galanin receptor binding;GO:0031766 type 3 galanin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030133 transport vesicle;GO:0031045 dense core granule", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1904306 positive regulation of gastro-intestinal system smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "M0R8L2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08949-1", "uniprot_id": "TF2AA_RAT", "mass": 41563.0, "length": 377, "protein_name": "Transcription initiation factor IIA subunit 1", "gene_name": "Gtf2a1", "organism": "Rat", "refseq_name": "transcription initiation factor IIA subunit 1", "refseq_ac": "NP_071544", "gene_names_uniprotkb": "Gtf2a1", "gene_names_refseq": "Gtf2a1; Tf2a; TfIIa", "protein_names_uniprotkb": "Transcription initiation factor IIA subunit 1; General transcription factor IIA subunit 1; TFIIA p19 subunit; TFIIA p35 subunit", "protein_names_refseq": "TFIIA large subunit; general transcription factor 2a, 1; general transcription factor IIA subunit 1; general transcription factor IIa, 1 (37kD and 19kD subunits); transcription initiation factor IIA subunit 1", "tax_id": 10116, "disease": "", "pathway": " (rno:83830); (R-RNO-674695); (R-RNO-6807505); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-76042); (R-RNO-9018519)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "11159353;22673903", "class_list": "", "function": "TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0017025 TBP-class protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005672 transcription factor TFIIA complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08949-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35815-1", "uniprot_id": "ATX3_RAT", "mass": 40446.0, "length": 355, "protein_name": "Ataxin-3", "gene_name": "Atxn3", "organism": "Rat", "refseq_name": "ataxin-3", "refseq_ac": "NP_067734", "gene_names_uniprotkb": "Atxn3; Mjd; Sca3", "gene_names_refseq": "Atxn3; MJD1; Rsca3", "protein_names_uniprotkb": "Ataxin-3; 3.4.19.12; Machado-Joseph disease protein 1 homolog", "protein_names_refseq": "ataxin-3; machado-Joseph disease protein 1 homolog", "tax_id": 10116, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); Machado-Joseph disease (Disease Ontology:DOID:1440)", "pathway": " (rno:60331); (R-RNO-5689877); (R-RNO-9615017)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10732811;12486728;17696782;22673903;25143392;26880203", "class_list": "", "function": "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models., [RefSeq, PubMed]; Data support the importance of ATXN3 in neuronal cells and indicate that an expanded polyQ tract leads to a partial loss of the cellular function of ATXN3 that may be relevant to neurodegeneration., [RefSeq, PubMed]; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:17696782). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (By similarity). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12;3.6.4.6;1.14.11.-;2.3.2.31", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0070536 protein K63-linked deubiquitination;GO:0034605 cellular response to heat;GO:0035640 exploration behavior", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35815-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54880-1", "uniprot_id": "RPH3L_RAT", "mass": 33433.0, "length": 302, "protein_name": "Rab effector Noc2", "gene_name": "Rph3al", "organism": "Rat", "refseq_name": "rab effector Noc2", "refseq_ac": "NP_598275", "gene_names_uniprotkb": "Rph3al; Noc2", "gene_names_refseq": "Noc2; Rph3al", "protein_names_uniprotkb": "Rab effector Noc2; No C2 domains protein; Rabphilin-3A-like protein", "protein_names_refseq": "no C2 domains protein; rab effector Noc2; rabphilin-3A-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:171123)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11134008;14593078;14722103;17067543;18573236;26024738;9367993", "class_list": "", "function": "Discovery of the involvement of Rab3 and Noc2 in an insulin-regulated step in GLUT4 translocation suggests that the control of this translocation process is unexpectedly similar to regulated secretion and particularly pancreatic insulin-vesicle release., [RefSeq, PubMed]; Noc2 is a potential partner of Munc13, a component of the machinery that controls vesicle priming and insulin exocytosis, [RefSeq, PubMed]; Our results suggest that the Noc2/Rab27 complex is an important constituent of the early stages of IPR-stimulated amylase release. Erratum:[Arch Biochem Biophys. 2007 Sep 1;465(1):301], [RefSeq, PubMed]; Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in rat cells, [RefSeq, PubMed]; Three Rab3/27 effectors, Granuphilin, Noc2, and Rabphilin, in PC12 cells using fluorescence recovery after photobleaching of EGFP-tagged proteins., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0030274 LIM domain binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0030141 secretory granule;GO:0045202 synapse;GO:0030658 transport vesicle membrane;GO:0098793 presynapse", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032024 positive regulation of insulin secretion;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0050714 positive regulation of protein secretion;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O54880-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55004-1", "uniprot_id": "RNAS4_RAT", "mass": 16903.0, "length": 147, "protein_name": "Ribonuclease 4", "gene_name": "Rnase4", "organism": "Rat", "refseq_name": "ribonuclease 4 precursor", "refseq_ac": "NP_064467", "gene_names_uniprotkb": "Rnase4", "gene_names_refseq": "Rab1; Rnase4", "protein_names_uniprotkb": "Ribonuclease 4; 3.1.27.-; RL3; RNase 4", "protein_names_refseq": "RL3; RNase 4; ribonuclease 4 precursor; ribonuclease 4; ribonuclease A b1; ribonuclease, RNase A family 4", "tax_id": 10116, "disease": "", "pathway": " (rno:56759)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9602056", "class_list": "", "function": "Cleaves preferentially after uridine bases. Has antimicrobial activity against uropathogenic E.coli (UPEC). Probably contributes to urinary tract sterility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0050830 defense response to Gram-positive bacterium;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O55004-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55006-1", "uniprot_id": "ROB1_RAT", "mass": 26187.0, "length": 240, "protein_name": "Protein RoBo-1", "gene_name": "Lypd8l1", "organism": "Rat", "refseq_name": "protein RoBo-1 precursor", "refseq_ac": "NP_113725", "gene_names_uniprotkb": "Lypd8l1", "gene_names_refseq": "DMT-1; Lypd8l1", "protein_names_uniprotkb": "Protein RoBo-1; Rodent bone protein", "protein_names_refseq": "divalent metal transporter-1; protein RoBo-1 precursor; protein RoBo-1; rodent bone protein", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); familial isolated trichomegaly (Disease Ontology:DOID:0111566)", "pathway": " (rno:24906)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17614955;9461570", "class_list": "", "function": "May play a novel role in the growth or remodeling of bone., [UniProtKB, PubMed]; The lack of translocation of DMT1 with heme dosing suggests another protein may be present to transport iron released from heme., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0046849 bone remodeling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O55006-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55099-1", "uniprot_id": "AURKB_RAT", "mass": 39234.0, "length": 343, "protein_name": "Aurora kinase B", "gene_name": "Aurkb", "organism": "Rat", "refseq_name": "aurora kinase B", "refseq_ac": "NP_446201", "gene_names_uniprotkb": "Aurkb; Aik2; Aim1; Airk2; Ark2; Stk12; Stk1; Stk5", "gene_names_refseq": "ARK-2; Aim1; Aurkb; STK-1; Stk12", "protein_names_uniprotkb": "Aurora kinase B; 2.7.11.1; ARK-2; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B", "protein_names_refseq": "AIM-1; aurora 1; aurora kinase B; aurora- and Ipl1-like midbody-associated protein 1; aurora-B; aurora-related kinase 2; aurora/IPL1-related kinase 2; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B", "tax_id": 10116, "disease": "brain cancer (Disease Ontology:DOID:1319); endometrial carcinoma (Disease Ontology:DOID:2871); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:114592); (R-RNO-141430); (R-RNO-141444); (R-RNO-174178); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-4615885); (R-RNO-5663220); (R-RNO-6804756); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 11, "publication_count": 7, "publication_id_list": "11950924;14751927;29393594;31533043;31563141;31819079;9450992", "class_list": "", "function": "A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport., [RefSeq, PubMed]; Aurora B kinase during mitosis and cytokinesis, [RefSeq, PubMed]; Cdc7 kinase stimulates Aurora B kinase in M-phase. Publication Status: Online-Only, [RefSeq, PubMed]; Findings indicated that aurora kinase B plays a critical role in spinal microgliosis and neuropathic pain, [RefSeq, PubMed]; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (By similarity). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:9450992). Required for central/midzone spindle assembly and cleavage furrow formation (By similarity). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (By similarity). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (By similarity). Phosphorylation of INCENP leads to increased AURKB activity (By similarity). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (By similarity). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (By similarity). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (By similarity). AURKB is also required for kinetochore localization of BUB1 and SGO1 (By similarity). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (By similarity). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (By similarity). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; When overexpressed in megakaryocytes of transgenic mice, the phenotype includes increased transgenic mRNA, but not protein, in polyploidy megakaryocytes, further suggesting that Aurora-B is regulated at the protein level., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8N1", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.3.2.23;2.7.11.12;2.7.11.26;2.7.11.34;2.3.2.24;3.4.22.49;2.7.10.2;2.7.1.150;3.6.4.12;2.7.11.13;4.1.1.32;2.3.2.-;2.7.11.19;2.7.2.3;2.7.11.11;3.4.25.1;3.4.21.-;2.7.11.31;3.1.3.16;3.6.5.-;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;3.6.5.2;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019900 kinase binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0051233 spindle midzone", "go_biological_process": "GO:0031117 positive regulation of microtubule depolymerization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043687 post-translational protein modification;GO:0044839 cell cycle G2/M phase transition;GO:0032466 negative regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O55099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55193-1", "uniprot_id": "CCR2_RAT", "mass": 42763.0, "length": 373, "protein_name": "C-C chemokine receptor type 2", "gene_name": "Ccr2", "organism": "Rat", "refseq_name": "C-C chemokine receptor type 2", "refseq_ac": "NP_068638", "gene_names_uniprotkb": "Ccr2; Cmkbr2", "gene_names_refseq": "Ccr2", "protein_names_uniprotkb": "C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2", "protein_names_refseq": "C-C CKR-2; C-C chemokine receptor type 2; CC-CKR-2; CCR-2; chemokine (C-C motif) receptor 2; chemokine receptor CCR2", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Coronavirus infectious disease (Disease Ontology:DOID:0080599); polymyositis (Disease Ontology:DOID:0080745); dermatomyositis (Disease Ontology:DOID:10223); pleural tuberculosis (Disease Ontology:DOID:106); age related macular degeneration (Disease Ontology:DOID:10871); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sarcoidosis (Disease Ontology:DOID:11335); prediabetes syndrome (Disease Ontology:DOID:11716); posterior uveitis (Disease Ontology:DOID:12574); intermediate uveitis (Disease Ontology:DOID:12732); Kawasaki disease (Disease Ontology:DOID:13378); aggressive periodontitis (Disease Ontology:DOID:1474); urticaria (Disease Ontology:DOID:1555); fungal infectious disease (Disease Ontology:DOID:1564); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); demyelinating disease (Disease Ontology:DOID:3213); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); inclusion body myositis (Disease Ontology:DOID:3429); macular degeneration (Disease Ontology:DOID:4448); rhinitis (Disease Ontology:DOID:4483); periapical granuloma (Disease Ontology:DOID:4617); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); periapical periodontitis (Disease Ontology:DOID:823); lung disease (Disease Ontology:DOID:850); myeloid sarcoma (Disease Ontology:DOID:8683); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:60463)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "31805255;32164451;32650794;36219898;36470227;9655467", "class_list": "", "function": "CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion., [RefSeq, PubMed]; CCL2/CCR2 system in neuroepithelial radial glia progenitor cells: involvement in stimulatory, sexually dimorphic effects of maternal ethanol on embryonic development of hypothalamic peptide neurons. Publication Status: Online-Only, [RefSeq, PubMed]; CCR2 Positron Emission Tomography for the Assessment of Abdominal Aortic Aneurysm Inflammation and Rupture Prediction., [RefSeq, PubMed]; Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (By similarity). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MiR-506-3p Relieves Neuropathic Pain following Brachial Plexus Avulsion via Mitigating Microglial Activation through Targeting the CCL2-CCR2 Axis., [RefSeq, PubMed]; Monocyte chemotactic protein (MCP)-1 (CCL2) and its receptor (CCR2) are elevated in chronic heart failure facilitating lung monocyte infiltration and differentiation which may contribute to lung fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0042802 identical protein binding;GO:0019955 cytokine binding;GO:0071791 chemokine (C-C motif) ligand 5 binding;GO:0031727 CCR2 chemokine receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55193-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55227-1", "uniprot_id": "UNC50_RAT", "mass": 30436.0, "length": 259, "protein_name": "Protein unc-50 homolog", "gene_name": "Unc50", "organism": "Rat", "refseq_name": "protein unc-50 homolog", "refseq_ac": "NP_620274", "gene_names_uniprotkb": "Unc50; Uncl", "gene_names_refseq": "Unc50; Uncl", "protein_names_uniprotkb": "Protein unc-50 homolog; Uncoordinated-like protein", "protein_names_refseq": "protein unc-50 homolog; unc-50 homolog; unc-50 related protein (UNCL); uncoordinated-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:192356)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10980252;17004066", "class_list": "", "function": "Involved in the cell surface expression of neuronal nicotinic receptors (PubMed:10980252). Binds RNA (PubMed:10980252)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0034394 protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O55227-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70276-1", "uniprot_id": "RPE65_RAT", "mass": 61004.0, "length": 533, "protein_name": "Retinoid isomerohydrolase", "gene_name": "Rpe65", "organism": "Rat", "refseq_name": "retinoid isomerohydrolase", "refseq_ac": "NP_446014", "gene_names_uniprotkb": "Rpe65", "gene_names_refseq": "Rpe65", "protein_names_uniprotkb": "Retinoid isomerohydrolase; 3.1.1.64; 5.3.3.22; All-trans-retinyl-palmitate hydrolase; Lutein isomerase; Meso-zeaxanthin isomerase; Retinal pigment epithelium-specific 65 kDa protein; Retinol isomerase", "protein_names_refseq": "RPE65, retinoid isomerohydrolase; all-trans-retinyl-palmitate hydrolase; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium 65-like; retinal pigment epithelium 65; retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein 65; retinoid isomerohydrolase; retinol isomerase", "tax_id": 10116, "disease": "Leber congenital amaurosis 2 (Disease Ontology:DOID:0110016); retinitis pigmentosa 20 (Disease Ontology:DOID:0110353); retinitis pigmentosa 87 (Disease Ontology:DOID:0112144); retinitis pigmentosa (Disease Ontology:DOID:10584); squamous cell carcinoma (Disease Ontology:DOID:1749); basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (rno:89826); (R-RNO-2453902)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29569173;9512345", "class_list": "", "function": "Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The damaged retinal pigment epithelium showed earlier expression of PCNA and RPE65 than photoreceptor out segments, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1M8Q2", "ec_number_list": "3.1.1.64;5.3.3.22", "go_molecular_function": "GO:0046872 metal ion binding;GO:0031210 phosphatidylcholine binding;GO:0001786 phosphatidylserine binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0001523 retinoid metabolic process;GO:0003407 neural retina development;GO:0042572 retinol metabolic process;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70276-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88275-1", "uniprot_id": "PPARG_RAT", "mass": 57567.0, "length": 505, "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "Pparg", "organism": "Rat", "refseq_name": "peroxisome proliferator-activated receptor gamma isoform 2", "refseq_ac": "NP_001138838", "gene_names_uniprotkb": "Pparg; Nr1c3", "gene_names_refseq": "PPARgamma2; Pparg", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; PPAR-gamma", "protein_names_refseq": "PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator activator receptor, gamma; peroxisome proliferator-activated receptor gamma isoform 2", "tax_id": 10116, "disease": "familial partial lipodystrophy (Disease Ontology:DOID:0050440); diabetic encephalopathy (Disease Ontology:DOID:0050850); glomerulosclerosis (Disease Ontology:DOID:0050851); abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); familial partial lipodystrophy type 3 (Disease Ontology:DOID:0070204); polycystic kidney disease (Disease Ontology:DOID:0080322); Graves ophthalmopathy (Disease Ontology:DOID:0081120); congenital generalized lipodystrophy type 2 (Disease Ontology:DOID:0111136); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); hyperandrogenism (Disease Ontology:DOID:11613); cardiovascular system disease (Disease Ontology:DOID:1287); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); primary pulmonary hypertension (Disease Ontology:DOID:14557); cognitive disorder (Disease Ontology:DOID:1561); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pancreatitis (Disease Ontology:DOID:4989); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); lipodystrophy (Disease Ontology:DOID:811); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25664); (R-RNO-381340); (R-RNO-383280); (R-RNO-9841922)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10438514;10797535;12777391;22240811;27984083;29969905;31403945;35121022;35688256;37986543;38237016;38594496;38648706;38770649;8943212;8953045;9030579", "class_list": "", "function": "DNMT3a-mediated methylation of PPARgamma promote intervertebral disc degeneration by regulating the NF-kappaB pathway., [RefSeq, PubMed]; Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-gamma axis., [RefSeq, PubMed]; Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids. Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metabolites. Ligand-binding results in a conformational change in the receptor, promoting dissociation of repressors and recruitment of coactivators, and subsequent activation of target gene expression. Specifically binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase (By similarity). Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses (By similarity). Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Nuclear receptor that acts as the key factor controlling the development of adipocytes. Specifically activated by 15-deoxy-delta12,14-prostaglandin J2 ligand during early adipogenesis, driving differentiation of all types of adipocytes (white, beige and brown). Acts together with retinoic acid receptor RXRA, forming the ARF6 complex, which acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Following recruitment of TLE3, promotes differentiation of white adipocytes. Following recruitment of PRDM16, promotes differentiation of myoblastic precursors into brown adipose cells (BAT), which are specialized in dissipating energy in the form of heat in response to cold or excess feeding. Also mediates diffentiation of white adipocytes into beige adipocytes by mediating recruitment of PRDM16., [UniProtKB, UniProtKB]; PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis., [RefSeq, PubMed]; PPARgamma alleviates preeclampsia development by regulating lipid metabolism and ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; SMYD2-Methylated PPARgamma Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 34, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWG0;Q9R197", "ec_number_list": "", "go_molecular_function": "GO:0050693 LBD domain binding;GO:0097677 STAT family protein binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043235 receptor complex", "go_biological_process": "GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus;GO:0032385 positive regulation of intracellular cholesterol transport;GO:1904179 positive regulation of adipose tissue development;GO:2000230 negative regulation of pancreatic stellate cell proliferation;GO:0010888 negative regulation of lipid storage", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O88275-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88298-1", "uniprot_id": "RHD_RAT", "mass": 46583.0, "length": 422, "protein_name": "Blood group Rh(D) polypeptide", "gene_name": "Rhd", "organism": "Rat", "refseq_name": "blood group Rh(D) polypeptide isoform 1", "refseq_ac": "NP_071950", "gene_names_uniprotkb": "Rhd; Rh30; Rhced", "gene_names_refseq": "Rhced; Rhd; Rh", "protein_names_uniprotkb": "Blood group Rh(D) polypeptide; Erythrocyte membrane glycoprotein Rh30", "protein_names_refseq": "Rhesus blood group CE and D; blood group Rh(D) polypeptide isoform 1; blood group Rh(D) polypeptide; erythrocyte membrane glycoprotein Rh30", "tax_id": 10116, "disease": "Rh isoimmunization (Disease Ontology:DOID:4175)", "pathway": " (rno:60414)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16227429;9705835", "class_list": "", "function": "May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008519 ammonium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0048821 erythrocyte development;GO:0072488 ammonium transmembrane transport;GO:0060586 multicellular organismal-level iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88298-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88350-1", "uniprot_id": "RBBP9_RAT", "mass": 20995.0, "length": 186, "protein_name": "Serine hydrolase RBBP9", "gene_name": "Rbbp9", "organism": "Rat", "refseq_name": "serine hydrolase RBBP9", "refseq_ac": "NP_062092", "gene_names_uniprotkb": "Rbbp9; Bog", "gene_names_refseq": "Rbbp9", "protein_names_uniprotkb": "Serine hydrolase RBBP9; 3.1.-.-; B5T-overexpressed gene protein; Protein BOG; RBBP-9; Retinoblastoma-binding protein 9", "protein_names_refseq": "B5T-overexpressed gene protein; RBBP-9; putative hydrolase RBBP9; retinoblastoma-binding protein 9; serine hydrolase RBBP9", "tax_id": 10116, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); thrombosis (Disease Ontology:DOID:0060903); thrombophilia due to activated protein C resistance (Disease Ontology:DOID:0111902); sensorineural hearing loss (Disease Ontology:DOID:10003); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); portal hypertension (Disease Ontology:DOID:10762); Budd-Chiari syndrome (Disease Ontology:DOID:11512); Behcet's disease (Disease Ontology:DOID:13241); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); factor V deficiency (Disease Ontology:DOID:2216); hepatitis (Disease Ontology:DOID:2237); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); cerebral infarction (Disease Ontology:DOID:3526); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); retinal artery occlusion (Disease Ontology:DOID:8483); pulmonary embolism (Disease Ontology:DOID:9477); hypereosinophilic syndrome (Disease Ontology:DOID:999)", "pathway": " (rno:29459)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9697699", "class_list": "", "function": "Serine hydrolase. Catalyzes the hydrolytic activation of amino acid ester of the antiviral prodrug valacyclovir to its corresponding active drug, acyclovir (By similarity). May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (By similarity). May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T1H7", "ec_number_list": "3.1.-.-", "go_molecular_function": "GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0042127 regulation of cell population proliferation;GO:0006805 xenobiotic metabolic process;GO:0060510 type II pneumocyte differentiation;GO:0009624 response to nematode", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88350-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88397-1", "uniprot_id": "SO1A5_RAT", "mass": 74577.0, "length": 670, "protein_name": "Solute carrier organic anion transporter family member 1A5", "gene_name": "Slco1a5", "organism": "Rat", "refseq_name": "solute carrier organic anion transporter family member 1A5", "refseq_ac": "NP_110465", "gene_names_uniprotkb": "Slco1a5; Oatp1a5; Oatp3; Slc21a7; Slco1a2", "gene_names_refseq": "OATP-3; Oatp3; Slc21a7; Slco1a2; Slco1a5", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1A5; OATP-3; Organic anion-transporting polypeptide 3; Sodium-independent organic anion transporter 3; Solute carrier family 21 member 7", "protein_names_refseq": "organic anion-transporting polypeptide 3; sodium-independent organic anion transporter 3; solute carrier family 21 (fatty acid transporter) member 7; solute carrier family 21 member 7; solute carrier organic anion transporter family member 1A5; solute carrier organic anion transporter family, member 1A2", "tax_id": 10116, "disease": "", "pathway": " (rno:80900)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11093941;11967025;12606759;17957449;19129463;21454685;22899169;33132311;9712861", "class_list": "", "function": "Consistently suggested that Oatp1a5 is contributing to the intestinal absorption, [RefSeq, PubMed]; Inflammation-Induced Attenuation of Prostaglandin D2 Elimination across Rat Blood-Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug Resistance-Associated Protein 4., [RefSeq, PubMed]; Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney., [RefSeq, PubMed]; Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), estrone 3-sulfate and prostaglandin E2, at the plasma membrane (PubMed:11093941, PubMed:19129463, PubMed:9712861). Responsible for intestinal absorption of bile acids (PubMed:11093941). Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (PubMed:19129463, PubMed:9712861). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate., [RefSeq, PubMed]; The intestinal absorption of ciprofloxacin could be affected by influx transporters such as Oatp1a5., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQR8", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity;GO:0015349 thyroid hormone transmembrane transporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015721 bile acid and bile salt transport;GO:0050892 intestinal absorption;GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88397-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00684-1", "uniprot_id": "RNS1B_RAT", "mass": 16823.0, "length": 152, "protein_name": "Ribonuclease pancreatic beta-type", "gene_name": "Rnase1", "organism": "Rat", "refseq_name": "ribonuclease pancreatic beta-type precursor", "refseq_ac": "NP_001025075", "gene_names_uniprotkb": "Rnase1; Rib-1; Rib1; Rns1", "gene_names_refseq": "RL1; Rib1; Rnase1", "protein_names_uniprotkb": "Ribonuclease pancreatic beta-type; 4.6.1.18; RL1; RNase 1 gamma; RNase A", "protein_names_refseq": "RNase 1 gamma; pancreatic ribonuclease; ribonuclease 1 pancreatic; ribonuclease RNase A family 1; ribonuclease pancreatic beta-type precursor; ribonuclease pancreatic beta-type; ribonuclease, RNase A family, 1 (pancreatic)", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:364304)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10090281;12399926;4710592;6873294;7174650", "class_list": "", "function": "Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity)., [UniProtKB]; Molecular evolution and gene duplication, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.18;3.6.4.10", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004540 RNA nuclease activity;GO:0004522 ribonuclease A activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00684-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00731-1", "uniprot_id": "CBPA1_RAT", "mass": 47197.0, "length": 419, "protein_name": "Carboxypeptidase A1", "gene_name": "Cpa1", "organism": "Rat", "refseq_name": "carboxypeptidase A1 preproprotein", "refseq_ac": "NP_058694", "gene_names_uniprotkb": "Cpa1; Cpa", "gene_names_refseq": "Cpa1", "protein_names_uniprotkb": "Carboxypeptidase A1; 3.4.17.1", "protein_names_refseq": "carboxypeptidase A1 (pancreatic); carboxypeptidase A1 preproprotein", "tax_id": 10116, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); Charcot-Marie-Tooth disease axonal type 2L (Disease Ontology:DOID:0110174); cataract 9 multiple types (Disease Ontology:DOID:0110266); autosomal dominant distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111206); pancreatitis (Disease Ontology:DOID:4989); cataract (Disease Ontology:DOID:83); ocular hypertension (Disease Ontology:DOID:9282); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (rno:24269)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15865404;21572518;22178042;3182872;6275388", "class_list": "", "function": "Carboxypeptidase A, dipeptidase and Na+/K+ ATPase levels in the rat intestine change when exposed to different doses of cadmium, [RefSeq, PubMed]; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data show that latexin protein expression was reduced after SNI, and the decrease of latexin was associated with an increase of the activity of carboxypeptidase A. Publication Status: Online-Only, [RefSeq, PubMed]; Gene transcripts for CPA1 in mesentery and other extrapancreatic tissues indicate that CPA1 might play a role in the renin-angiotensin system in addition to it'sfunction as digestive enzyme, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.17.1", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008238 exopeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0046686 response to cadmium ion;GO:0006691 leukotriene metabolic process;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00731-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00762-1", "uniprot_id": "TRY1_RAT", "mass": 25959.0, "length": 246, "protein_name": "Serine protease 1", "gene_name": "Prss1", "organism": "Rat", "refseq_name": "serine protease 1 precursor", "refseq_ac": "NP_036767", "gene_names_uniprotkb": "Prss1; Trp1; Try1; Tryp1", "gene_names_refseq": "PTRYI; Prss1; RATPTRYI; Try1", "protein_names_uniprotkb": "Serine protease 1; 3.4.21.4; Anionic trypsin I; Anionic trypsin-1; Beta-trypsin; Cationic trypsinogen; Pretrypsinogen I; Trypsin I; Trypsin-1", "protein_names_refseq": "anionic trypsin I; anionic trypsin-1; beta-trypsin; cationic trypsinogen; pancreatic trypsin 1; pretrypsinogen I; protease, serine 1; protease, serine, 1 (trypsin 1); protease, serine, 2; serine protease 1 precursor", "tax_id": 10116, "disease": "cystic fibrosis (Disease Ontology:DOID:1485); pancreatitis (Disease Ontology:DOID:4989); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24691); (R-RNO-1462054); (R-RNO-1592389); (R-RNO-6798695); (R-RNO-6803157)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "12027901;22768227;35045793;6094547;6896710", "class_list": "", "function": "Ectopic anionic trypsin I in rat lungs induced by virus infection may trigger virus spread in rat lungs, [RefSeq, PubMed]; Effects of tRNA-derived fragments and microRNAs regulatory network on pancreatic acinar intracellular trypsinogen activation., [RefSeq, PubMed]; These results indicate that mucin plays an important role in the preservation of the mucosal barrier and that ischemia but not digestive enzymes disturbs mucin integrity, while digestive enzymes actively mediate epithelial cell disruption., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.4;3.4.24.7;3.5.4.5;2.3.2.5;3.4.24.34;3.2.1.17;3.4.24.17;4.1.2.13;3.4.24.22;3.4.21.1;3.4.21.34;3.4.21.20;1.16.3.1;3.4.24.-;3.4.23.5;3.3.2.6;3.4.11.4;5.4.2.2;1.1.1.42;3.4.24.23;3.4.24.35;3.4.21.39;3.4.21.59;3.1.3.48;3.4.22.27;3.5.1.3;3.4.19.9;1.8.3.2;3.5.1.23;3.5.1.-;3.6.1.6", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007584 response to nutrient;GO:0035094 response to nicotine;GO:0031000 response to caffeine;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00762-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00763-1", "uniprot_id": "TRY2_RAT", "mass": 26228.0, "length": 246, "protein_name": "Anionic trypsin-2", "gene_name": "Prss2", "organism": "Rat", "refseq_name": "anionic trypsin-2 precursor", "refseq_ac": "NP_036861", "gene_names_uniprotkb": "Prss2; Try2", "gene_names_refseq": "Prss2; Ptryss2", "protein_names_uniprotkb": "Anionic trypsin-2; 3.4.21.4; Anionic trypsin II; Pretrypsinogen II; Serine protease 2", "protein_names_refseq": "anionic trypsin II; anionic trypsin-2 precursor; anionic trypsin-2; pancreatic trypsin 2; pancreatic trypsin II; pretrypsinogen II; serine protease 2", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy 15 (Disease Ontology:DOID:0070398); cholangiocarcinoma (Disease Ontology:DOID:4947); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (rno:25052); (R-RNO-1462054); (R-RNO-1592389); (R-RNO-6798695); (R-RNO-6803157)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "18815551;1881877;23650361;3112942;6094547;6896710;8634241", "class_list": "", "function": "Activated microglia increase neurogenesis through secretion of PRSS2., [RefSeq, PubMed]; Nicotine impairs secretion rather than production of pancreatic trypsinogen 2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.4;3.4.24.7;3.5.4.5;2.3.2.5;3.4.24.34;3.2.1.17;3.4.24.17;4.1.2.13;3.4.24.22;3.4.21.1;3.4.21.34;3.4.21.20;1.16.3.1;3.4.24.-;3.4.23.5;3.3.2.6;3.4.11.4;5.4.2.2;1.1.1.42;3.4.24.23;3.4.24.35;3.4.21.39;3.4.21.59;3.1.3.48;3.4.22.27;3.5.1.3;3.4.19.9;1.8.3.2;3.5.1.23;3.5.1.-;3.6.1.6", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007584 response to nutrient;GO:0007586 digestion;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P00763-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01159-1", "uniprot_id": "SCOTP_RAT", "mass": 1582.0, "length": 15, "protein_name": "Scotophobin", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Scotophobin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "4558348;4558349", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P01159-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01347-1", "uniprot_id": "REL1_RAT", "mass": 20489.0, "length": 186, "protein_name": "Prorelaxin 1", "gene_name": "Rln1", "organism": "Rat", "refseq_name": "prorelaxin 1 precursor", "refseq_ac": "NP_038199", "gene_names_uniprotkb": "Rln1; Rln", "gene_names_refseq": "RELAX; Rln1", "protein_names_uniprotkb": "Prorelaxin 1", "protein_names_refseq": "Relaxin 1 (H1); preprorelaxin; prorelaxin 1 precursor; prorelaxin 1", "tax_id": 10116, "disease": "tyrosinemia type I (Disease Ontology:DOID:0050726); hypertension (Disease Ontology:DOID:10763); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:25616); (R-RNO-444821)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14659888;24640565;24640566;28606038;28776188;31811156;7004862;7231533", "class_list": "", "function": "Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals., [UniProtKB]; Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Relaxin-1 mRNA in the hearts of diabetic rats was significantly increased and that relaxin-3 mRNA expression at different time points was decreased. In addition, significant down-regulation of the mRNA expression of RXFP1 and RXFP3 was observed at 4 weeks after Streptozocin., [RefSeq, PubMed]; The aim of the present study was to explore a role of relaxin at specific stages of spermatogenesis using a co-culture of rat Sertoli and germ cells., [RefSeq, PubMed]; The digestive tract has been shown to express relaxin receptors; the hormone appears to exert site-specific effects acting at the neural or at the smooth muscle level, mainly by a nitric oxide-mediated mechanism. (Review) Review article, [RefSeq, PubMed]; We have shown that relaxin stimulates Sertoli cell proliferation through the activation of MEK/ERK1/2 and PI3K/AKT pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78N50", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0060443 mammary gland morphogenesis;GO:0007283 spermatogenesis;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P01347-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02317-1", "uniprot_id": "STP1_RAT", "mass": 6395.0, "length": 55, "protein_name": "Spermatid nuclear transition protein 1", "gene_name": "Tnp1", "organism": "Rat", "refseq_name": "spermatid nuclear transition protein 1", "refseq_ac": "NP_058752", "gene_names_uniprotkb": "Tnp1", "gene_names_refseq": "Tnp1", "protein_names_uniprotkb": "Spermatid nuclear transition protein 1; STP-1; TP-1; Testis-specific basic protein", "protein_names_refseq": "STP-1; TP-1; spermatid nuclear transition protein 1; testis-specific basic protein", "tax_id": 10116, "disease": "", "pathway": " (rno:24839)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1112834;19506090;2524424;2820847;4829397", "class_list": "", "function": "Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction., [UniProtKB, UniProtKB]; TP1 and TP2 may have concerted functional roles during chromatin remodeling in mammalian spermiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0001673 male germ cell nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0019953 sexual reproduction;GO:0006338 chromatin remodeling;GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P02317-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02401-1", "uniprot_id": "RLA2_RAT", "mass": 11692.0, "length": 115, "protein_name": "Large ribosomal subunit protein P2", "gene_name": "Rplp2", "organism": "Rat", "refseq_name": "large ribosomal subunit protein P2", "refseq_ac": "NP_001025192", "gene_names_uniprotkb": "Rplp2; Rp2", "gene_names_refseq": "RP2; Rplp2", "protein_names_uniprotkb": "Large ribosomal subunit protein P2; 60S acidic ribosomal protein P2", "protein_names_refseq": "60S acidic ribosomal protein P2-like; 60S acidic ribosomal protein P2; large ribosomal subunit protein P2; ribosomal protein, large P2", "tax_id": 10116, "disease": "", "pathway": " (rno:140662); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 5, "publication_id_list": "16641100;1742361;1923757;22673903;7096359", "class_list": "", "function": "Plays an important role in the elongation step of protein synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499W9", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0043021 ribonucleoprotein complex binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0045727 positive regulation of translation;GO:0002181 cytoplasmic translation;GO:1904401 cellular response to Thyroid stimulating hormone;GO:0002182 cytoplasmic translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P02401-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02696-1", "uniprot_id": "RET1_RAT", "mass": 15834.0, "length": 135, "protein_name": "Retinol-binding protein 1", "gene_name": "Rbp1", "organism": "Rat", "refseq_name": "retinol-binding protein 1", "refseq_ac": "NP_036865", "gene_names_uniprotkb": "Rbp1; Rbp-1", "gene_names_refseq": "Rbp1", "protein_names_uniprotkb": "Retinol-binding protein 1; CRBP-I; CRBP; Cellular retinol-binding protein I; Cellular retinol-binding protein", "protein_names_refseq": "CRBP-I; CRBP; cellular retinol-binding protein I; retinol binding protein 1, cellular; retinol-binding protein 1", "tax_id": 10116, "disease": "multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:25056); (R-RNO-2453902); (R-RNO-975634)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11934897;12850148;31746385;3472205;3584109;4039728;6541654;6942701;7683727", "class_list": "", "function": "Cytoplasmic retinol-binding protein (PubMed:12850148, PubMed:7683727). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Retinal proteomic evaluation of rats following streptozotocininjection using shotgun proteomics., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:1904768 all-trans-retinol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0044297 cell body", "go_biological_process": "GO:0030852 regulation of granulocyte differentiation;GO:0001523 retinoid metabolic process;GO:0055088 lipid homeostasis;GO:0042572 retinol metabolic process;GO:0042573 retinoic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P02696-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04631-1", "uniprot_id": "S100B_RAT", "mass": 10744.0, "length": 92, "protein_name": "Protein S100-B", "gene_name": "S100b", "organism": "Rat", "refseq_name": "protein S100-B", "refseq_ac": "NP_037323", "gene_names_uniprotkb": "S100b", "gene_names_refseq": "S100P; S100b", "protein_names_uniprotkb": "Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B", "protein_names_refseq": "S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein, beta (neural); S100 protein, beta polypeptide, neural; protein S100-B", "tax_id": 10116, "disease": "sleep apnea (Disease Ontology:DOID:0050847); stroke (Disease Ontology:DOID:0051061); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); migraine without aura (Disease Ontology:DOID:12783); dilated cardiomyopathy (Disease Ontology:DOID:12930); aspergillosis (Disease Ontology:DOID:13564); Machado-Joseph disease (Disease Ontology:DOID:1440); depressive disorder (Disease Ontology:DOID:1596); brain ischemia (Disease Ontology:DOID:2316); West Nile fever (Disease Ontology:DOID:2366); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); demyelinating disease (Disease Ontology:DOID:3213); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); borna disease (Disease Ontology:DOID:5154); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); neuromyelitis optica (Disease Ontology:DOID:8869); brain disease (Disease Ontology:DOID:936); bacterial meningitis (Disease Ontology:DOID:9470)", "pathway": " (rno:25742); (R-RNO-445989); (R-RNO-879415); (R-RNO-933542)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10211826;12042313;12470955;14621986;15823027;1653388;18949447;19910580;20351179;34051593;34680103;34792689;37384931;3818655;6093041;8794737;9485423", "class_list": "", "function": "Autocrine S100B in astrocytes promotes VEGF-dependent inflammation and oxidative stress and causes impaired neuroprotection., [RefSeq, PubMed]; Glycolipid toxicity induces osteogenic dysfunction via the TLR4/S100B pathway., [RefSeq, PubMed]; Pathophysiological aspects of neonatal anoxia and temporal expression of S100beta in different brain regions., [RefSeq, PubMed]; Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:14621986, PubMed:15823027, PubMed:18949447, PubMed:20351179). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (PubMed:15823027). Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (By similarity). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (By similarity). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (PubMed:19910580). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity). May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; The Role of the C-Terminal Lysine of S100P in S100P-Induced Cell Migration and Metastasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0097490 sympathetic neuron projection extension;GO:0007155 cell adhesion;GO:0007611 learning or memory;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P04631-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04646-1", "uniprot_id": "RL35A_RAT", "mass": 12554.0, "length": 110, "protein_name": "Large ribosomal subunit protein eL33", "gene_name": "Rpl35a", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL33", "refseq_ac": "NP_067087", "gene_names_uniprotkb": "Rpl35a", "gene_names_refseq": "Rpl35al1; Rpl35a", "protein_names_uniprotkb": "Large ribosomal subunit protein eL33; 60S ribosomal protein L35a", "protein_names_refseq": "60S ribosomal protein L35a; large ribosomal subunit protein eL33; ribosomal protein L35a-like 1; ribosomal protein L35a-like", "tax_id": 10116, "disease": "", "pathway": " (rno:103690996); (rno:57809)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "3753935", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for the proliferation and viability of hematopoietic cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0000049 tRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P04646-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04917-1", "uniprot_id": "SRGN_RAT", "mass": 18577.0, "length": 179, "protein_name": "Serglycin", "gene_name": "Srgn", "organism": "Rat", "refseq_name": "serglycin precursor", "refseq_ac": "NP_064459", "gene_names_uniprotkb": "Srgn; Pgsg; Prg1; Prg", "gene_names_refseq": "Pgsg; Srgn", "protein_names_uniprotkb": "Serglycin; Chondroitin sulfate proteoglycan core protein; Cytolytic granule proteoglycan core protein; PG19 core protein; Proteoglycan 10K core protein; Secretory granule proteoglycan core protein", "protein_names_refseq": "PG19 core protein; chondroitin sulfate proteoglycan core protein; cytolytic granule proteoglycan core protein; proteoglycan 10K core protein; proteoglycan peptide core protein; secretory granule proteoglycan core protein; serglycin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:56782); (R-RNO-114608)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "2352541;2427521;3366780;3919394", "class_list": "", "function": "Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF and may also regulate protease secretion. Inhibits bone mineralization (By similarity)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0042588 zymogen granule;GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0030141 secretory granule", "go_biological_process": "GO:0016485 protein processing;GO:0006915 apoptotic process;GO:0031214 biomineral tissue development;GO:0033363 secretory granule organization;GO:0033371 T cell secretory granule organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P04917-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05426-1", "uniprot_id": "RL7_RAT", "mass": 30329.0, "length": 260, "protein_name": "Large ribosomal subunit protein uL30", "gene_name": "Rpl7", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rpl7", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein uL30; 60S ribosomal protein L7", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 10, "publication_count": 2, "publication_id_list": "3624274;7654221", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0005840 ribosome", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0097421 liver regeneration;GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P05426-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05504-1", "uniprot_id": "ATP6_RAT", "mass": 25076.0, "length": 226, "protein_name": "ATP synthase F(0) complex subunit a", "gene_name": "Mt-atp6", "organism": "Rat", "refseq_name": "ATP synthase F0 subunit 6", "refseq_ac": "YP_665634", "gene_names_uniprotkb": "Mt-atp6; Atp6; Atpase6; Mtatp6", "gene_names_refseq": "ATP6", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit a; F-ATPase protein 6; Proton-conducting channel, ATP synthase F(0) complex subunit a", "protein_names_refseq": "ATP synthase F0 subunit 6", "tax_id": 10116, "disease": "left ventricular noncompaction (Disease Ontology:DOID:0060480); NARP syndrome (Disease Ontology:DOID:0111273); Leber hereditary optic neuropathy and dystonia (Disease Ontology:DOID:0111755); prostate cancer (Disease Ontology:DOID:10283); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Parkinson's disease (Disease Ontology:DOID:14330); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); parathyroid carcinoma (Disease Ontology:DOID:1540); breast cancer (Disease Ontology:DOID:1612); thyroid cancer (Disease Ontology:DOID:1781); multiple sclerosis (Disease Ontology:DOID:2377); Leigh disease (Disease Ontology:DOID:3652); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557); mitochondrial metabolism disease (Disease Ontology:DOID:700); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:26197); (R-RNO-163210); (R-RNO-5419276); (R-RNO-8949613); (R-RNO-9837999)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "11163232;24185961;2504926;29393594;8529844", "class_list": "", "function": "Subunit a, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. With the subunit c (ATP5MC1), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix. Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9T2E9", "ec_number_list": "", "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:0015252 proton channel activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0055093 response to hyperoxia;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P05504-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05943-1", "uniprot_id": "S10AA_RAT", "mass": 11075.0, "length": 95, "protein_name": "Protein S100-A10", "gene_name": "S100a10", "organism": "Rat", "refseq_name": "protein S100-A10", "refseq_ac": "NP_112376", "gene_names_uniprotkb": "S100a10", "gene_names_refseq": "S100a10; p11", "protein_names_uniprotkb": "Protein S100-A10; Calpactin I light chain; Calpactin-1 light chain; Cellular ligand of annexin II; Nerve growth factor-induced protein 42C; S100 calcium-binding protein A10; p10 protein; p11", "protein_names_refseq": "S-100 related protein, clone 42C; annexin II ligand; calpactin I light chain; calpactin-1 light chain; cellular ligand of annexin II; nerve growth factor-induced protein 42C; p10 protein; protein S100-A10", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:81778); (R-RNO-75205)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12050667;27103570;29393594;32886017;3422491;34787893;38646936", "class_list": "", "function": "Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Expression of p11 and Heteromeric TASK Channels in Rat Carotid Body Glomus Cells and Nerve Growth Factor-differentiated PC12 Cells., [RefSeq, PubMed]; Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that there are breeder-dependent differences in vulnerability to stress in the chronic mild stress (CMS) model of depression, which might bear on the validity of the model and contribute to contradictory findings and difficulties of replication between laboratories. P11 mRNA expression seems to be differently regulated depending on the quality of the stress response evoked by CMS exposure., [RefSeq, PubMed]; S100A10 regulates tumor necrosis factor alpha-induced apoptosis in chondrocytes via the reactive oxygen species/nuclear factor-kappa B pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BJ98", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0043547 positive regulation of GTPase activity;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0072659 protein localization to plasma membrane;GO:0051496 positive regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P05943-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07153-1", "uniprot_id": "RPN1_RAT", "mass": 68304.0, "length": 605, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "gene_name": "Rpn1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rpn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit; RPN-I; Ribophorin I; Ribophorin-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25596); (R-RNO-9768727); (R-RNO-9931295)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "2335524;3031084;34502162;38843836", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0015833 peptide transport;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P07153-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08289-1", "uniprot_id": "PPBT_RAT", "mass": 57659.0, "length": 524, "protein_name": "Alkaline phosphatase, tissue-nonspecific isozyme", "gene_name": "Alpl", "organism": "Rat", "refseq_name": "alkaline phosphatase, tissue-nonspecific isozyme precursor", "refseq_ac": "NP_001416309", "gene_names_uniprotkb": "Alpl", "gene_names_refseq": "AP-TNAP; Akp2; Alpl; PHOA; TNAP; TNSALP", "protein_names_uniprotkb": "Alkaline phosphatase, tissue-nonspecific isozyme; 3.1.3.1; 3.9.1.1; AP-TNAP; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; TNAP; TNSALP", "protein_names_refseq": "Tissue-nonspecific ALP alkaline phosphatase; alkaline phosphatase 2, liver; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific isozyme precursor; alkaline phosphatase, tissue-nonspecific isozyme; phosphoamidase; phosphocreatine phosphatase; tissue-nonspecific alkaline phosphatase", "tax_id": 10116, "disease": "adult hypophosphatasia (Disease Ontology:DOID:0110913); infantile hypophosphatasia (Disease Ontology:DOID:0110914); childhood hypophosphatasia (Disease Ontology:DOID:0110915); familial combined hyperlipidemia (Disease Ontology:DOID:13809); hypophosphatasia (Disease Ontology:DOID:14213); arteriosclerosis (Disease Ontology:DOID:2349); uremia (Disease Ontology:DOID:4676); in situ carcinoma (Disease Ontology:DOID:8719); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:25586); (R-RNO-163125)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "22673903;2544423;27590577;27885436;2834351;2895632;31969558;32710882;3422431;8612632", "class_list": "", "function": "Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis. Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi), pyridoxal 5'-phosphate (PLP) and N-phosphocreatine are natural substrates. Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration. Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix. Also promotes dephosphorylation of osteopontin (SSP1), an inhibitor of hydroxyapatite crystallization in its phosphorylated state; it is however unclear whether ALPL/TNAP mediates SSP1 dephosphorylation via a direct or indirect manner. Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters. Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (By similarity). Also capable of dephosphorylating microbial products, such as lipopolysaccharides (LPS) as well as other phosphorylated small-molecules, such as poly-inosine:cytosine (poly I:C) (By similarity). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating hydrolysis of N-phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data show that nonylphenol (NP) increased serum alkaline phosphatase, lead to liver damage and can increase the expression of heme oxygenase-1 (HO1) and growth arrest and DNA-damage-inducible 45 beta protein (Gadd45b) genes and may modify the toxic effects on liver through induction of oxidative stress., [RefSeq, PubMed]; He rats body weight were decreased, the cartilage histological structure were disrupted, the cartilage and serum contents of Al and the serum level of C-telopeptide of type II collagen were all increased, the serum level of type II collagen (Col II) and alkaline phosphatase (ALP), and the mRNA expressions of TGF-beta1, BMP-2, ALP and Col II were all decreased in the AlCl3-treated groups compared with those in control g..., [RefSeq, PubMed]; TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-beta1/Smads and activating P53 signaling pathways. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 27, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 56, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P14055;P70707", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;2.4.2.31;3.6.4.-;2.3.2.27;3.1.3.2;5.6.2.4;3.1.3.1;3.1.3.48;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.75;3.9.1.1;6.1.1.12;3.1.3.5;3.1.3.91;3.1.3.89;3.1.3.99;3.1.3.35;3.6.1.-;3.1.4.1;3.6.1.9;3.5.1.92;2.7.4.3;3.6.1.1;3.1.3.-;3.6.1.16;3.6.1.53;3.2.2.6;3.1.4.-;3.1.3.74;3.6.1.25;3.6.1.14;3.6.1.6;3.4.24.-;3.6.-.-;3.1.4.50;3.1.3.16;3.4.21.53;3.4.11.9;5.6.2.5", "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0033883 pyridoxal phosphatase activity;GO:0052732 phosphoethanolamine phosphatase activity;GO:0004035 alkaline phosphatase activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0065010 extracellular membrane-bounded organelle;GO:0005615 extracellular space;GO:0005758 mitochondrial intermembrane space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:1904383 response to sodium phosphate;GO:0032496 response to lipopolysaccharide;GO:0051384 response to glucocorticoid;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 6.8, "record_id": "P08289-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08424-1", "uniprot_id": "RENI_RAT", "mass": 44276.0, "length": 402, "protein_name": "Renin", "gene_name": "Ren1; Ren", "organism": "Rat", "refseq_name": "renin precursor", "refseq_ac": "NP_036774", "gene_names_uniprotkb": "Ren1; Ren; Ren", "gene_names_refseq": "RATRENAA; RENAA; Ren1; Ren", "protein_names_uniprotkb": "Renin; 3.4.23.15; Angiotensinogenase", "protein_names_refseq": "angiotensinogenase; renin 1 structural; renin precursor", "tax_id": 10116, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); atrial fibrillation (Disease Ontology:DOID:0060224); autosomal dominant tubulointerstitial kidney disease 4 (Disease Ontology:DOID:0061119); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); human cytomegalovirus infection (Disease Ontology:DOID:0080827); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); hand, foot and mouth disease (Disease Ontology:DOID:10881); primary biliary cholangitis (Disease Ontology:DOID:12236); toxic shock syndrome (Disease Ontology:DOID:14115); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); acute kidney failure (Disease Ontology:DOID:3021); primary hyperaldosteronism (Disease Ontology:DOID:446); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic fatigue syndrome (Disease Ontology:DOID:8544); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24715); (R-RNO-2022377)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "3039496;3047403;3287330;34841988;8490598", "class_list": "", "function": "Morphology and cyclooxygenase-2 and renin expression in the kidney of young spontaneously hypertensive rats., [RefSeq, PubMed]; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q63497", "ec_number_list": "3.4.23.15;3.4.23.5", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0005102 signaling receptor binding;GO:0005159 insulin-like growth factor receptor binding;GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0006508 proteolysis;GO:0032496 response to lipopolysaccharide;GO:0001822 kidney development;GO:0002003 angiotensin maturation;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P08424-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08541-1", "uniprot_id": "UD2B2_RAT", "mass": 60986.0, "length": 530, "protein_name": "UDP-glucuronosyltransferase 2B2", "gene_name": "Ugt2b", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ugt2b; Ugt2b2", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 2B2; 2.4.1.17; 3-hydroxyandrogen-specific UDPGT; RLUG23; UDPGT 2B2; UDPGTr-4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-156588); (R-RNO-9749641); (R-RNO-9757110)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1909872;2429951;3003696;7492328", "class_list": "glycogene;glycosyltransferase", "function": "UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B2 acts on various endogenous steroids, especially etiocholanolone and androsterone., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.17", "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P08541-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09118-1", "uniprot_id": "URIC_RAT", "mass": 34934.0, "length": 303, "protein_name": "Uricase", "gene_name": "Uox", "organism": "Rat", "refseq_name": "uricase isoform 1", "refseq_ac": "NP_446220", "gene_names_uniprotkb": "Uox", "gene_names_refseq": "UOX-2; Uox; Uri2; Uri", "protein_names_uniprotkb": "Uricase; 1.7.3.3; Urate oxidase", "protein_names_refseq": "urate oxidase 2; uricase isoform 1; uricase", "tax_id": 10116, "disease": "nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); gout (Disease Ontology:DOID:13189); hyperuricemia (Disease Ontology:DOID:1920)", "pathway": " (rno:114768)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "1520291;1783398;1999285;22673903;2338140;2920046;3182808;3194410;3267221;33648977;34437605", "class_list": "", "function": "Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Uricase deficiency causes mild and multiple organ injuries in rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.7.3.3", "go_molecular_function": "GO:0004846 urate oxidase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006145 purine nucleobase catabolic process;GO:0019628 urate catabolic process;GO:0006144 purine nucleobase metabolic process;GO:0006154 adenosine catabolic process;GO:0006157 deoxyadenosine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P09118-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09895-1", "uniprot_id": "RL5_RAT", "mass": 34459.0, "length": 297, "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "Rpl5", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL18", "refseq_ac": "NP_112361", "gene_names_uniprotkb": "Rpl5", "gene_names_refseq": "Rpl5", "protein_names_uniprotkb": "Large ribosomal subunit protein uL18; 60S ribosomal protein L5", "protein_names_refseq": "60S ribosomal protein L5; large ribosomal subunit protein uL18", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 6 (Disease Ontology:DOID:0111879); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); glioblastoma (Disease Ontology:DOID:3068); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (rno:81763); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "3117543;3624282;8626719", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0031625 ubiquitin protein ligase binding;GO:0003730 mRNA 3'-UTR binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0045727 positive regulation of translation;GO:0006364 rRNA processing;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P09895-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2C4-1", "uniprot_id": "RM10_RAT", "mass": 29940.0, "length": 263, "protein_name": "Large ribosomal subunit protein uL10m", "gene_name": "Mrpl10", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mrpl10", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein uL10m; 39S ribosomal protein L10, mitochondrial; L10mt; MRP-L10; MRP-L8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9857009", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:1990904 ribonucleoprotein complex;GO:0005840 ribosome", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C2C4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11506-13", "uniprot_id": "AT2B2_RAT", "mass": 136811.0, "length": 1243, "protein_name": "Plasma membrane calcium-transporting ATPase 2", "gene_name": "Atp2b2", "organism": "Rat", "refseq_name": "plasma membrane calcium-transporting ATPase 2", "refseq_ac": "NP_036640", "gene_names_uniprotkb": "Atp2b2", "gene_names_refseq": "Atp2b2; PMCA2", "protein_names_uniprotkb": "Plasma membrane calcium-transporting ATPase 2; 7.2.2.10; PMCA2; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2", "protein_names_refseq": "ATPase, Ca++ transporting, plasma membrane 2; plasma membrane Ca++-ATPase; plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 2", "tax_id": 10116, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429); autosomal dominant nonsyndromic deafness 82 (Disease Ontology:DOID:0070603); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (rno:24215)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1315513;22673903;25315779;28153703;2837461;31032369;36707954;38843836;8428948", "class_list": "", "function": "ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (By similarity). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (By similarity). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Although modification of PMCAs composition could provide some protection against calcium overload, reduction of PMCA2 appeared to be more detrimental to the cells than deficiency of PMCA3. Under pathological conditions, including inflammatory CCL5 action and long-lasting Ca(2+) dyshomeostasis, insufficient cell protection may result in progressive degeneration and death of neurons. Publication Status: Online-Only, [RefSeq, PubMed]; GlyT2 activity is pre-synaptically controlled by physical and functional association with plasma membrane PMCA2, PMCA3, and NCX1., [RefSeq, PubMed]; Higher occupancy of Calm2 and Calm3 promoters by NFATc2 and increased expression of these genes in response to NFATc2 silencing were demonstrated in PMCA2 and PMCA3-reduced lines., [RefSeq, PubMed]; [Estradiol regulates the expression of plasma membrane Ca[2+]-ATPase isoform 2 in inner ear of rats]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63443", "ec_number_list": "7.2.2.10", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0003407 neural retina development;GO:0007626 locomotory behavior;GO:0042472 inner ear morphogenesis;GO:0050808 synapse organization;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P11506-13", "record_type": "protein" }, { "uniprot_canonical_ac": "P13432-1", "uniprot_id": "SMR1_RAT", "mass": 15970.0, "length": 146, "protein_name": "SMR1 protein", "gene_name": "Smr3b; Vcsa1", "organism": "Rat", "refseq_name": "SMR1 protein precursor", "refseq_ac": "NP_036816", "gene_names_uniprotkb": "Smr3b; Vcsa1; Smr1", "gene_names_refseq": "Arp; P2-VA1; RATSMR1A; Smr1g; Smr1; Smr3b; Vcsa1", "protein_names_uniprotkb": "SMR1 protein; SMR1-related pentapeptide; VCS-alpha 1", "protein_names_refseq": "SMR1 protein precursor; VCS-alpha 1; Variable coding sequence A1 (androgen regulated protein (SMR1) gene); androgen regulated protein; sialorphin", "tax_id": 10116, "disease": "", "pathway": " (rno:24867)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12835417;15555512;19109528;19428993;2125424;24803544;3186744;7557446;8112327;9321881;9362294", "class_list": "", "function": "Autonomic nervous system regulates secretion of anti-inflammatory prohormone SMR1 from rat salivary glands., [RefSeq, PubMed]; Correlation of erectile function, testosterone levels and Vcsa1 expression in orchiectomized rats and controls, [RefSeq, PubMed]; Sialorphin increased, in a dose-related manner, the occurrence of intromissions across the successive ejaculatory sequences., [RefSeq, PubMed]; Sialorphin is an endogenous inhibitor of neprilysin. Inhibits the breakdown of Met-enkephalin and substance P in isolated tissue from the dorsal zone of the rat spinal cord. Has an analgesic effect when administered to rats by intravenous injection., [UniProtKB]; Sialorphin may be involved in the modulation of mineral balance between at least four systems: kidney, bone, tooth and circulation., [UniProtKB]; Sialorphin protects endogenous enkephalins released after nociceptive stimuli by inhibiting neprilysin in vivo. It is a natural systemically active regulator of NEP activity & is a physiological modulator of pain perception after injury, [RefSeq, PubMed]; Submandibular gland peptide T is able to directly or indirectly down-regulate cardiovascular depression induced by septic shock (endotoxin stimuli), or anaphylactic challenge (nematode antigen sensitization)., [UniProtKB]; When rat corporal smooth muscle cells were treated with CoCl2 or low oxygen tension to mimic hypoxia, Vcsa1 was increased tenfold., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030414 peptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0010466 negative regulation of peptidase activity;GO:0051930 regulation of sensory perception of pain;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P13432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13471-1", "uniprot_id": "RS14_RAT", "mass": 16259.0, "length": 151, "protein_name": "Small ribosomal subunit protein uS11", "gene_name": "Rps14", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS11", "refseq_ac": "NP_073163", "gene_names_uniprotkb": "Rps14", "gene_names_refseq": "Rps14", "protein_names_uniprotkb": "Small ribosomal subunit protein uS11; 40S ribosomal protein S14", "protein_names_refseq": "40S ribosomal protein S14; small ribosomal subunit protein uS11", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); chromosome 5q deletion syndrome (Disease Ontology:DOID:0090016); anemia (Disease Ontology:DOID:2355)", "pathway": " (rno:29284); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 2, "publication_id_list": "2587275;38843836", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0048027 mRNA 5'-UTR binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030218 erythrocyte differentiation;GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P13471-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13638-1", "uniprot_id": "AT1B2_RAT", "mass": 33412.0, "length": 290, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-2", "gene_name": "Atp1b2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Atp1b2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-2; Sodium/potassium-dependent ATPase subunit beta-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Compton-North congenital myopathy (Disease Ontology:DOID:0080101); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (R-RNO-210991); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1039/D0MO00044B;14749213;2170236;24090084;2538450;34106099;38843836;8918259", "class_list": "", "function": "Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth., [UniProtKB, UniProtKB, UniProtKB]; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 31, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0046982 protein heterodimerization activity;GO:0051117 ATPase binding;GO:0001671 ATPase activator activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0097449 astrocyte projection;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:1903976 negative regulation of glial cell migration;GO:0010976 positive regulation of neuron projection development;GO:0045494 photoreceptor cell maintenance;GO:0050821 protein stabilization;GO:0001895 retina homeostasis", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P13638-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15725-1", "uniprot_id": "TNR4_RAT", "mass": 29895.0, "length": 271, "protein_name": "Tumor necrosis factor receptor superfamily member 4", "gene_name": "Tnfrsf4", "organism": "Rat", "refseq_name": "tumor necrosis factor receptor superfamily member 4 precursor", "refseq_ac": "NP_037181", "gene_names_uniprotkb": "Tnfrsf4; Ox40; Txgp1l", "gene_names_refseq": "Ox40; Tnfrsf4; Txgp1", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 4; MRC OX40; OX40 antigen; OX40L receptor", "protein_names_refseq": "MRC OX40; OX40 antigen; OX40L receptor; Tax-transcriptionally activated glycoprotein 1; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor receptor superfamily member 4 precursor; tumor necrosis factor receptor superfamily, member 4; tumor necrosis factor superfamily, member 4", "tax_id": 10116, "disease": "immunodeficiency 16 (Disease Ontology:DOID:0111935); cervical squamous cell carcinoma (Disease Ontology:DOID:3744)", "pathway": " (rno:25572); (R-RNO-5669034)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20871162;2157591", "class_list": "", "function": "OX40 and OX40L may play a role in the pathogenesis of experimental allegic neuritis., [RefSeq, PubMed]; Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005031 tumor necrosis factor receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0006968 cellular defense response;GO:0030890 positive regulation of B cell proliferation;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P15725-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16257-1", "uniprot_id": "TSPO_RAT", "mass": 18940.0, "length": 169, "protein_name": "Translocator protein", "gene_name": "Tspo", "organism": "Rat", "refseq_name": "translocator protein", "refseq_ac": "NP_036647", "gene_names_uniprotkb": "Tspo; Bzrp; Mbr", "gene_names_refseq": "Bzrp; MBR; PTBZR02; Ptbzr; RATPTBZR02; Tspo", "protein_names_uniprotkb": "Translocator protein; Mitochondrial benzodiazepine receptor; PBR; PKBS; Peripheral-type benzodiazepine receptor", "protein_names_refseq": "Benzodiazepin receptor (peripheral); PBR; PKBS; benzodiazepine receptor, peripheral; mitochondrial benzodiazepine receptor; peripheral-type benzodiazepine receptor; translocator protein", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); obsessive-compulsive disorder (Disease Ontology:DOID:10933); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); bulimia nervosa (Disease Ontology:DOID:12129); vitiligo (Disease Ontology:DOID:12306); pathological gambling (Disease Ontology:DOID:12399); intermittent explosive disorder (Disease Ontology:DOID:12401); leiomyoma (Disease Ontology:DOID:127); eumycotic mycetoma (Disease Ontology:DOID:13078); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); cholesterol ester storage disease (Disease Ontology:DOID:14502); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cannabis dependence (Disease Ontology:DOID:1849); ovarian cancer (Disease Ontology:DOID:2394); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); bipolar disorder (Disease Ontology:DOID:3312); renal cell carcinoma (Disease Ontology:DOID:4450); uremia (Disease Ontology:DOID:4676); schizophrenia (Disease Ontology:DOID:5419); fibromyalgia (Disease Ontology:DOID:631); amphetamine abuse (Disease Ontology:DOID:670); psoriasis (Disease Ontology:DOID:8893); cannabis abuse (Disease Ontology:DOID:9505); neonatal abstinence syndrome (Disease Ontology:DOID:9828); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24230); (R-RNO-196108)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "1332914;20336621;2555358;29393594;37013248;37408083;37717810;38517482;38908539", "class_list": "", "function": "Identification of a mechanism promoting mitochondrial sterol accumulation during myocardial ischemia-reperfusion: role of TSPO and STAR., [RefSeq, PubMed]; Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis (By similarity). Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:2555358)., [UniProtKB, PubMed, PubMed]; Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum. Publication Status: Online-Only, [RefSeq, PubMed]; TSPO exacerbates acute cerebral ischemia/reperfusion injury by inducing autophagy dysfunction., [RefSeq, PubMed]; TSPO in pancreatic beta cells and its possible involvement in type 2 diabetes., [RefSeq, PubMed]; Translocator protein alleviates allodynia and improves Schwann cell function against diabetic peripheral neuropathy via activation of the Nrf2-dependent antioxidant system and promoting autophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 41, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0005497 androgen binding;GO:0008503 benzodiazepine receptor activity;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane", "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:0071476 cellular hypotonic response;GO:0060242 contact inhibition;GO:0060252 positive regulation of glial cell proliferation;GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P16257-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16599-1", "uniprot_id": "TNFA_RAT", "mass": 25806.0, "length": 235, "protein_name": "Tumor necrosis factor", "gene_name": "Tnf", "organism": "Rat", "refseq_name": "tumor necrosis factor", "refseq_ac": "NP_036807", "gene_names_uniprotkb": "Tnf; Tnfa; Tnfsf2", "gene_names_refseq": "RATTNF; TNF-alpha; Tnfa; Tnf", "protein_names_uniprotkb": "Tumor necrosis factor; Cachectin; N-terminal fragment; NTF; TNF-alpha; TNF-a; Tumor necrosis factor ligand superfamily member 2", "protein_names_refseq": "cachectin; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor ligand superfamily member 2; tumor necrosis factor", "tax_id": 10116, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); mevalonic aciduria (Disease Ontology:DOID:0050452); Weill-Marchesani syndrome (Disease Ontology:DOID:0050475); inflammatory bowel disease (Disease Ontology:DOID:0050589); hypochromic microcytic anemia (Disease Ontology:DOID:0050642); small cell carcinoma (Disease Ontology:DOID:0050685); chorioamnionitis (Disease Ontology:DOID:0050697); cardiomyopathy (Disease Ontology:DOID:0050700); obstructive sleep apnea (Disease Ontology:DOID:0050848); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); cardiac arrest (Disease Ontology:DOID:0060319); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); immunodeficiency 127 (Disease Ontology:DOID:0061092); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); erythema nodosum (Disease Ontology:DOID:0080750); Graves ophthalmopathy (Disease Ontology:DOID:0081120); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); sensorineural hearing loss (Disease Ontology:DOID:10003); leprosy (Disease Ontology:DOID:1024); thalassemia (Disease Ontology:DOID:10241); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); silicosis (Disease Ontology:DOID:10325); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); renal hypertension (Disease Ontology:DOID:1073); otitis media (Disease Ontology:DOID:10754); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); intracranial aneurysm (Disease Ontology:DOID:10941); cholesteatoma of middle ear (Disease Ontology:DOID:10964); anogenital venereal wart (Disease Ontology:DOID:11168); spondyloarthropathy (Disease Ontology:DOID:1123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); trachoma (Disease Ontology:DOID:11265); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); cicatricial pemphigoid (Disease Ontology:DOID:11656); diabetic angiopathy (Disease Ontology:DOID:11713); iron deficiency anemia (Disease Ontology:DOID:11758); hepatorenal syndrome (Disease Ontology:DOID:11823); esophagitis (Disease Ontology:DOID:11963); primary biliary cholangitis (Disease Ontology:DOID:12236); beta thalassemia (Disease Ontology:DOID:12241); neutropenia (Disease Ontology:DOID:1227); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); aplastic anemia (Disease Ontology:DOID:12449); hepatitis A (Disease Ontology:DOID:12549); paracoccidioidomycosis (Disease Ontology:DOID:12662); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); intermediate uveitis (Disease Ontology:DOID:12732); migraine without aura (Disease Ontology:DOID:12783); mucopolysaccharidosis VI (Disease Ontology:DOID:12800); autistic disorder (Disease Ontology:DOID:12849); Sjogren's syndrome (Disease Ontology:DOID:12894); keratoconjunctivitis sicca (Disease Ontology:DOID:12895); dilated cardiomyopathy (Disease Ontology:DOID:12930); periventricular leukomalacia (Disease Ontology:DOID:13088); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); typhoid fever (Disease Ontology:DOID:13258); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); scleritis (Disease Ontology:DOID:13452); low tension glaucoma (Disease Ontology:DOID:13544); Fanconi anemia (Disease Ontology:DOID:13636); peptic esophagitis (Disease Ontology:DOID:13976); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); anterior uveitis (Disease Ontology:DOID:1407); toxic shock syndrome (Disease Ontology:DOID:14115); farmer's lung (Disease Ontology:DOID:14453); root resorption (Disease Ontology:DOID:14550); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); thrombocytopenia (Disease Ontology:DOID:1588); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); aortic valve stenosis (Disease Ontology:DOID:1712); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); Gaucher's disease (Disease Ontology:DOID:1926); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); transient cerebral ischemia (Disease Ontology:DOID:224); hidradenitis suppurativa (Disease Ontology:DOID:2280); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); dermatitis (Disease Ontology:DOID:2723); Mycobacterium avium complex disease (Disease Ontology:DOID:2755); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); cryoglobulinemia (Disease Ontology:DOID:2917); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); breast adenocarcinoma (Disease Ontology:DOID:3458); mixed connective tissue disease (Disease Ontology:DOID:3492); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); skin disease (Disease Ontology:DOID:37); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); gastritis (Disease Ontology:DOID:4029); heart valve disease (Disease Ontology:DOID:4079); liver disease (Disease Ontology:DOID:409); coronary restenosis (Disease Ontology:DOID:4247); radiculopathy (Disease Ontology:DOID:4306); cervical cancer (Disease Ontology:DOID:4362); pustulosis of palm and sole (Disease Ontology:DOID:4398); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); endophthalmitis (Disease Ontology:DOID:4692); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); retinal detachment (Disease Ontology:DOID:5327); schizophrenia (Disease Ontology:DOID:5419); cochlear disease (Disease Ontology:DOID:5463); kidney disease (Disease Ontology:DOID:557); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); lymphopenia (Disease Ontology:DOID:614); myositis (Disease Ontology:DOID:633); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); acne (Disease Ontology:DOID:6543); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); peritonitis (Disease Ontology:DOID:8283); extrinsic allergic alveolitis (Disease Ontology:DOID:841); corneal ulcer (Disease Ontology:DOID:8463); lung disease (Disease Ontology:DOID:850); dermatitis herpetiformis (Disease Ontology:DOID:8505); Cor pulmonale (Disease Ontology:DOID:8515); herpes zoster (Disease Ontology:DOID:8536); ulcerative colitis (Disease Ontology:DOID:8577); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); alcoholic gastritis (Disease Ontology:DOID:8680); vascular dementia (Disease Ontology:DOID:8725); bacterial pneumonia (Disease Ontology:DOID:874); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); hepatopulmonary syndrome (Disease Ontology:DOID:900); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); amyloidosis (Disease Ontology:DOID:9120); visceral leishmaniasis (Disease Ontology:DOID:9146); mucocutaneous leishmaniasis (Disease Ontology:DOID:9155); type 2 diabetes mellitus (Disease Ontology:DOID:9352); epididymitis (Disease Ontology:DOID:9402); acute myocardial infarction (Disease Ontology:DOID:9408); multiple myeloma (Disease Ontology:DOID:9538); bronchiectasis (Disease Ontology:DOID:9563); encephalitis (Disease Ontology:DOID:9588); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); muscular dystrophy (Disease Ontology:DOID:9884); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24835); (R-RNO-5357786); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5626978); (R-RNO-5668541); (R-RNO-75893)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "11477479;15060004;15935297;1627266;30980393;37899248;38279481;38321559;8224868", "class_list": "", "function": "Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Effect of huankuile on colon injury in rats with ulcerative colitis by reducing TNF-alpha and MMP9. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanism of TNF- alpha inducing apoptosis and autophagy of chondrocytes by activating NF- kappa B signal pathway. Publication Status: Online-Only, [RefSeq, PubMed]; TNF-alpha Mediated the Disruption of Hepatic Tight Junction Expression in Blood-Biliary Barrier of Colitis via Downregulating PI3K/AKT Signaling Pathway., [RefSeq, PubMed]; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 197, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6EE11;Q9JI26;Q9JI27", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0000976 transcription cis-regulatory region binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0030316 osteoclast differentiation;GO:2000866 positive regulation of estradiol secretion;GO:0060557 positive regulation of vitamin D biosynthetic process;GO:0032741 positive regulation of interleukin-18 production", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P16599-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17077-1", "uniprot_id": "RL9_RAT", "mass": 21893.0, "length": 192, "protein_name": "Large ribosomal subunit protein uL6", "gene_name": "Rpl9", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL6", "refseq_ac": "NP_001007599", "gene_names_uniprotkb": "Rpl9", "gene_names_refseq": "Rpl9", "protein_names_uniprotkb": "Large ribosomal subunit protein uL6; 60S ribosomal protein L9", "protein_names_refseq": "60S ribosomal protein L9; large ribosomal subunit protein uL6", "tax_id": 10116, "disease": "", "pathway": " (rno:29257); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "2227441;38843836", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:1990090 cellular response to nerve growth factor stimulus;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P17077-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17246-1", "uniprot_id": "TGFB1_RAT", "mass": 44329.0, "length": 390, "protein_name": "Transforming growth factor beta-1 proprotein", "gene_name": "Tgfb1", "organism": "Rat", "refseq_name": "transforming growth factor beta-1 proprotein precursor", "refseq_ac": "NP_067589", "gene_names_uniprotkb": "Tgfb1", "gene_names_refseq": "Tgfb1; Tgfb", "protein_names_uniprotkb": "Transforming growth factor beta-1 proprotein", "protein_names_refseq": "TGF-beta-1; transforming growth factor beta-1 proprotein precursor; transforming growth factor beta-1 proprotein", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); chorioamnionitis (Disease Ontology:DOID:0050697); atrial fibrillation (Disease Ontology:DOID:0060224); Camurati-Engelmann disease 1 (Disease Ontology:DOID:0061229); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); traumatic brain injury (Disease Ontology:DOID:0081292); prostate cancer (Disease Ontology:DOID:10283); berylliosis (Disease Ontology:DOID:10322); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); anogenital venereal wart (Disease Ontology:DOID:11168); chlamydia (Disease Ontology:DOID:11263); heart disease (Disease Ontology:DOID:114); osteoporosis (Disease Ontology:DOID:11476); familial hyperlipidemia (Disease Ontology:DOID:1168); factor VIII deficiency (Disease Ontology:DOID:12134); vitiligo (Disease Ontology:DOID:12306); aplastic anemia (Disease Ontology:DOID:12449); urethral obstruction (Disease Ontology:DOID:12577); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); pulmonary sarcoidosis (Disease Ontology:DOID:13406); biliary atresia (Disease Ontology:DOID:13608); eosinophilic esophagitis (Disease Ontology:DOID:13922); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); cystic fibrosis (Disease Ontology:DOID:1485); colon carcinoma (Disease Ontology:DOID:1520); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); colon cancer (Disease Ontology:DOID:219); osteochondrodysplasia (Disease Ontology:DOID:2256); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); tracheal stenosis (Disease Ontology:DOID:3227); atopic dermatitis (Disease Ontology:DOID:3310); carotid artery disease (Disease Ontology:DOID:3407); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); insulinoma (Disease Ontology:DOID:3892); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); cholangiocarcinoma (Disease Ontology:DOID:4947); myelofibrosis (Disease Ontology:DOID:4971); liver cirrhosis (Disease Ontology:DOID:5082); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); oral submucous fibrosis (Disease Ontology:DOID:5773); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); localized scleroderma (Disease Ontology:DOID:8472); lung disease (Disease Ontology:DOID:850); chronic myeloid leukemia (Disease Ontology:DOID:8552); actinic keratosis (Disease Ontology:DOID:8866); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); aphthous stomatitis (Disease Ontology:DOID:9663); pulmonary emphysema (Disease Ontology:DOID:9675); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:59086); (R-RNO-114608); (R-RNO-2129379); (R-RNO-2173788); (R-RNO-2173789); (R-RNO-2173791); (R-RNO-3000170); (R-RNO-8941855); (R-RNO-8941858); (R-RNO-8951936); (R-RNO-9839389)", "pathway_count": 11, "publication_count": 9, "publication_id_list": "11907708;2070682;2349108;26858265;29393594;37433223;38122948;38781757;39168432", "class_list": "", "function": "Combining experiments and bioinformatics to identify transforming growth factor-beta1 as a key regulator in angiotensin II-induced trophoblast senescence., [RefSeq, PubMed]; Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1 (By similarity). Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules' (PubMed:2070682). Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (PubMed:2070682). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner (By similarity). At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development (By similarity). At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Positively regulates odontoblastic differentiation in dental papilla cells, via promotion of IPO7-mediated translocation of phosphorylated SMAD2 to the nucleus and subsequent transcription of target genes (By similarity). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Recombinant Slit2 attenuates tracheal fibroblast activation in benign central airway obstruction by inhibiting the TGF-beta1/Smad3 signaling pathway., [RefSeq, PubMed]; Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin II-induced atrial fibrosis and vulnerability to atrial fibrillation via suppression of the TGF-beta1/smad2/3 signalling pathway., [RefSeq, PubMed]; Sleep deprivation disturbs uterine contractility and structure in pregnant rats: role of matrix metalloproteinase 9 and transforming growth factor-beta., [RefSeq, PubMed]; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 79, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q53YM8", "ec_number_list": "", "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0030141 secretory granule", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0060762 regulation of branching involved in mammary gland duct morphogenesis;GO:0030316 osteoclast differentiation;GO:0016202 regulation of striated muscle tissue development;GO:0060364 frontal suture morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P17246-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17702-1", "uniprot_id": "RL28_RAT", "mass": 15849.0, "length": 137, "protein_name": "Large ribosomal subunit protein eL28", "gene_name": "Rpl28", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rpl28", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein eL28; 60S ribosomal protein L28", "protein_names_refseq": "", "tax_id": 10116, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 10, "publication_count": 2, "publication_id_list": "2207170;36038000", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P17702-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18445-1", "uniprot_id": "RL27A_RAT", "mass": 16618.0, "length": 148, "protein_name": "Large ribosomal subunit protein uL15", "gene_name": "Rpl27a", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL15", "refseq_ac": "NP_001099760", "gene_names_uniprotkb": "Rpl27a", "gene_names_refseq": "Rpl27a", "protein_names_uniprotkb": "Large ribosomal subunit protein uL15; 60S ribosomal protein L27a", "protein_names_refseq": "60S ribosomal protein L27a; large ribosomal subunit protein uL15", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (rno:293418); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-9629569); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 12, "publication_count": 2, "publication_id_list": "2207170;38843836", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P18445-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18596-2", "uniprot_id": "AT2A3_RAT", "mass": 109359.0, "length": 999, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 3", "gene_name": "Atp2a3", "organism": "Rat", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 3", "refseq_ac": "NP_037046", "gene_names_uniprotkb": "Atp2a3", "gene_names_refseq": "Atp2a3; SERCA3", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; 7.2.2.10; Calcium pump 3; SERCA3; SR Ca(2+)-ATPase 3", "protein_names_refseq": "ATPase, Ca++ transporting, ubiquitous; SR Ca(2+)-ATPase 3; calcium pump 3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3", "tax_id": 10116, "disease": "Brody myopathy (Disease Ontology:DOID:0050692); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114)", "pathway": " (rno:25391); (R-RNO-418359); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10642281;2553713", "class_list": "", "function": "This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction., [UniProtKB, UniProtKB]; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R5I9", "ec_number_list": "2.7.11.17;7.2.2.10", "go_molecular_function": "GO:0005524 ATP binding;GO:0005246 calcium channel regulator activity;GO:0016887 ATP hydrolysis activity;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031090 organelle membrane;GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0097421 liver regeneration;GO:0032469 endoplasmic reticulum calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18596-2", "record_type": "protein" }, { "uniprot_canonical_ac": "P18889-1", "uniprot_id": "PORF1_RAT", "mass": 4142.0, "length": 37, "protein_name": "Putative preoptic regulatory factor 1", "gene_name": "Porf1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Porf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative preoptic regulatory factor 1; PORF-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2293025", "class_list": "", "function": "Precursor for a gonadotropin regulatory hormone (GNRH) related decapeptide., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0033798 thyroxine 5-deiodinase activity;GO:0031625 ubiquitin protein ligase binding;GO:0005179 hormone activity;GO:0004800 thyroxine 5'-deiodinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042404 thyroid hormone catabolic process;GO:0006629 lipid metabolic process;GO:0032496 response to lipopolysaccharide;GO:0050873 brown fat cell differentiation;GO:0006590 thyroid hormone generation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18889-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18890-1", "uniprot_id": "RHG39_RAT", "mass": 11572.0, "length": 101, "protein_name": "Rho GTPase-activating protein 39", "gene_name": "Arhgap39", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Arhgap39", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho GTPase-activating protein 39; PORF-2; Preoptic regulatory factor 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:500901)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;2293025", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098794 postsynapse;GO:0005634 nucleus;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007165 signal transduction;GO:0099173 postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18890-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19488-1", "uniprot_id": "UDB37_RAT", "mass": 60593.0, "length": 530, "protein_name": "UDP-glucuronosyltransferase 2B37", "gene_name": "Ugt2b37", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ugt2b37; Ugt2b5; Ugt2b6", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 2B37; 17-beta-hydroxysteroid-specific UDPGT; 2.4.1.17; UDP-glucuronosyltransferase R-21; UDPGT 2B37; UDPGTr-21; UDPGTr-5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-156588); (R-RNO-9749641); (R-RNO-9757110)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "1692835", "class_list": "glycogene;glycosyltransferase", "function": "UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. About 30-fold less active than Ugt2b17 toward testosterone and dihydrotestosterone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P19489", "ec_number_list": "2.4.1.17", "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P19488-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19814-1", "uniprot_id": "TGON3_RAT", "mass": 38305.0, "length": 357, "protein_name": "Trans-Golgi network integral membrane protein TGN38", "gene_name": "Tgoln2; Ttgn1", "organism": "Rat", "refseq_name": "trans-Golgi network integral membrane protein TGN38 precursor", "refseq_ac": "NP_620195", "gene_names_uniprotkb": "Tgoln2; Ttgn1", "gene_names_refseq": "Tgn38; Tgoln1; Tgoln2; Ttgn1", "protein_names_uniprotkb": "Trans-Golgi network integral membrane protein TGN38", "protein_names_refseq": "trans-Golgi network integral membrane protein TGN38 precursor; trans-Golgi network integral membrane protein TGN38; trans-golgi network protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:192152); (R-RNO-381426); (R-RNO-432722); (R-RNO-6811440); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8957275)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "10514494;15047867;2204342;22673903", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q4G0B6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19814-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19944-1", "uniprot_id": "RLA1_RAT", "mass": 11498.0, "length": 114, "protein_name": "Large ribosomal subunit protein P1", "gene_name": "Rplp1", "organism": "Rat", "refseq_name": "large ribosomal subunit protein P1", "refseq_ac": "NP_001007605", "gene_names_uniprotkb": "Rplp1", "gene_names_refseq": "Rplp1", "protein_names_uniprotkb": "Large ribosomal subunit protein P1; 60S acidic ribosomal protein P1", "protein_names_refseq": "60S acidic ribosomal protein P1; large ribosomal subunit protein P1; ribosomal protein, large, P1", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (rno:140661); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "1742361", "class_list": "", "function": "Plays an important role in the elongation step of protein synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0030295 protein kinase activator activity;GO:1990381 ubiquitin-specific protease binding;GO:0035800 deubiquitinase activator activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0030432 peristalsis;GO:0031223 auditory behavior;GO:0048634 regulation of muscle organ development;GO:0071626 mastication;GO:0097094 craniofacial suture morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P19944-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19945-1", "uniprot_id": "RLA0_RAT", "mass": 34215.0, "length": 317, "protein_name": "Large ribosomal subunit protein uL10", "gene_name": "Rplp0", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL10", "refseq_ac": "NP_071797", "gene_names_uniprotkb": "Rplp0; Arbp", "gene_names_refseq": "Arbp; Rplp0", "protein_names_uniprotkb": "Large ribosomal subunit protein uL10; 60S acidic ribosomal protein P0; 60S ribosomal protein L10E", "protein_names_refseq": "60S acidic ribosomal protein P0; 60S ribosomal protein L10E; acidic ribosomal phosphoprotein P0; large ribosomal subunit protein uL10; ribosomal protein, large, P0", "tax_id": 10116, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (rno:64205); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "1742361;22673903;38843836", "class_list": "", "function": "Ribosomal protein P0 is the functional equivalent of E.coli protein L10., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042277 peptide binding;GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0042254 ribosome biogenesis;GO:0007595 lactation;GO:0010269 response to selenium ion;GO:0071353 cellular response to interleukin-4", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P19945-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20280-1", "uniprot_id": "RL21_RAT", "mass": 18466.0, "length": 160, "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "Rpl21", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL21", "refseq_ac": "NP_445782", "gene_names_uniprotkb": "Rpl21", "gene_names_refseq": "Rpl21", "protein_names_uniprotkb": "Large ribosomal subunit protein eL21; 60S ribosomal protein L21", "protein_names_refseq": "60S ribosomal protein L21; large ribosomal subunit protein eL21", "tax_id": 10116, "disease": "hypotrichosis 12 (Disease Ontology:DOID:0110709)", "pathway": " (rno:79449)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2751657", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0001650 fibrillar center", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P20280-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20611-1", "uniprot_id": "PPAL_RAT", "mass": 48405.0, "length": 423, "protein_name": "Lysosomal acid phosphatase", "gene_name": "Acp2", "organism": "Rat", "refseq_name": "lysosomal acid phosphatase isoform 1 precursor", "refseq_ac": "NP_058684", "gene_names_uniprotkb": "Acp2", "gene_names_refseq": "Acp2; LAP", "protein_names_uniprotkb": "Lysosomal acid phosphatase; 3.1.3.2; LAP; Tartrate-inhibitable acid phosphatase", "protein_names_refseq": "Acid phosphatase 2, lysozymal; LMW-PTP-II low molecular weight phosphotyrosine protein phosphatase isozyme 2; lysosomal acid phosphatase isoform 1 precursor; lysosomal acid phosphatase", "tax_id": 10116, "disease": "Dent disease (Disease Ontology:DOID:0050699); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); osteopetrosis (Disease Ontology:DOID:13533)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2764916;38843836", "class_list": "", "function": "Lysosomal acid phosphatase that catalyzes the hydrolysis of orthophosphoric monoesters to alcohols and phosphate under acidic conditions (By similarity). May contribute to the removal of mannose-6-phosphate (Man6P) from lysosomal proteins after their delivery to lysosomes, acting in concert with ACP5 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]., [RefSeq]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q642D2", "ec_number_list": "3.1.3.2;3.1.3.1;3.1.3.48;3.9.1.1;3.1.3.5", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0003993 acid phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0045202 synapse;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0001501 skeletal system development;GO:0007040 lysosome organization;GO:0070305 response to cGMP;GO:0048102 autophagic cell death", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20611-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20788-1", "uniprot_id": "UCRI_RAT", "mass": 29446.0, "length": 274, "protein_name": "Cytochrome b-c1 complex subunit Rieske, mitochondrial", "gene_name": "Uqcrfs1", "organism": "Rat", "refseq_name": "cytochrome b-c1 complex subunit Rieske, mitochondrial", "refseq_ac": "NP_001008888", "gene_names_uniprotkb": "Uqcrfs1", "gene_names_refseq": "LRRGT00195; Uqcrfs1", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit Rieske, mitochondrial; 7.1.1.8; 8 kDa subunit 9; Complex III subunit 5; Complex III subunit IX; Cytochrome b-c1 complex subunit 11; Cytochrome b-c1 complex subunit 5; Liver regeneration-related protein LRRGT00195; RISP; Rieske iron-sulfur protein; Rieske protein UQCRFS1; UQCRFS1 MTS; UQCRFS1 mitochondrial targeting sequence; Ubiquinol-cytochrome c reductase 8 kDa protein; Ubiquinol-cytochrome c reductase iron-sulfur subunit", "protein_names_refseq": "RISP; Rieske protein UQCRFS1; complex III subunit 5; cytochrome b-c1 complex subunit 5; cytochrome b-c1 complex subunit Rieske, mitochondrial; liver regeneration-related protein LRRGT00195; rieske iron-sulfur protein; ubiquinol-cytochrome c reductase iron-sulfur subunit", "tax_id": 10116, "disease": "mitochondrial complex III deficiency (Disease Ontology:DOID:0111139); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:291103); (R-RNO-611105); (R-RNO-9865881)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12794875;2538119;26446791;27213235;34502162", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS) (By similarity). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mass spectrometric characterization of ubiquinol-cytochrome c reductase; ten of the 11 polypeptides present in this complex were detected directly by MALDI-TOFMS following electroelution of the active complex, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6QI13", "ec_number_list": "1.16.3.1;7.1.1.8;3.6.4.10;2.8.1.7", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0009725 response to hormone;GO:0009410 response to xenobiotic stimulus;GO:0022904 respiratory electron transport chain;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P20788-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23640-1", "uniprot_id": "RB27A_RAT", "mass": 25068.0, "length": 221, "protein_name": "Ras-related protein Rab-27A", "gene_name": "Rab27a", "organism": "Rat", "refseq_name": "ras-related protein Rab-27A", "refseq_ac": "NP_059013", "gene_names_uniprotkb": "Rab27a; Rab27", "gene_names_refseq": "Rab27a; ram", "protein_names_uniprotkb": "Ras-related protein Rab-27A; 3.6.5.2; GTP-binding protein Ram; Rab-27; Ram p25", "protein_names_refseq": "GTP-binding protein Ram; low Mr GTP-binding protein; rab-27; ram p25; ras-related protein Rab-27A", "tax_id": 10116, "disease": "hemophagocytic lymphohistiocytosis (Disease Ontology:DOID:0050120); Hermansky-Pudlak syndrome 1 (Disease Ontology:DOID:0060539); Griscelli syndrome type 2 (Disease Ontology:DOID:0060833); platelet storage pool deficiency (Disease Ontology:DOID:2223); non-Langerhans-cell histiocytosis (Disease Ontology:DOID:4330)", "pathway": " (rno:50645); (R-RNO-6798695); (R-RNO-8873719); (R-RNO-8876198); (R-RNO-9824585)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "1527078;2124544;23702376;25051489", "class_list": "", "function": "Data show that the intracellular M4M5 loop of human alpha1 subunit of Na+,K+-ATPase (ATP1a1) interacts directly with rat rab GTP-binding protein Rab27a. Erratum:[PLoS One. 2016 Feb 03;11(2):e0148719. doi: 10.1371/journal.pone.0148719. PMID: 26840778] Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB27A regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse., [UniProtKB, UniProtKB]; These findings indicated that Madd functions as a guanine nucleotide exchange factor for Rab27 in parotid acinar cells and regulates isoproterenol-stimulated amylase release., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KMA7", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.3.2.5;2.7.11.1;3.6.5.5;2.7.1.35;3.6.1.5;3.4.24.34;3.2.1.17;3.5.3.1;2.3.1.16;2.3.1.9;2.3.1.155;3.4.23.5;1.4.3.22;1.4.3.-;3.1.3.48;2.5.1.60;3.1.21.-;3.5.1.3;3.6.1.-;2.7.10.2;3.4.19.9;3.6.5.4;1.8.3.2;3.2.1.166;3.6.1.6;3.2.1.18;3.4.18.1", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0030425 dendrite;GO:0005764 lysosome;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071985 multivesicular body sorting pathway;GO:0051875 pigment granule localization;GO:1990182 exosomal secretion;GO:1903307 positive regulation of regulated secretory pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P23640-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23977-1", "uniprot_id": "SC6A3_RAT", "mass": 68746.0, "length": 619, "protein_name": "Sodium-dependent dopamine transporter", "gene_name": "Slc6a3", "organism": "Rat", "refseq_name": "sodium-dependent dopamine transporter", "refseq_ac": "NP_036826", "gene_names_uniprotkb": "Slc6a3", "gene_names_refseq": "Dat1; Slc6a3", "protein_names_uniprotkb": "Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3", "protein_names_refseq": "DA transporter; DAT; sodium-dependent dopamine transporter; solute carrier family 6 (neurotransmitter transporter), member 3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); classic dopamine transporter deficiency syndrome (Disease Ontology:DOID:0070489); mild cognitive impairment (Disease Ontology:DOID:0080832); Parkinsonism (Disease Ontology:DOID:0080855); dopamine beta-hydroxylase deficiency (Disease Ontology:DOID:0090145); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); hyperprolactinemia (Disease Ontology:DOID:12700); high grade glioma (Disease Ontology:DOID:3070); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24898); (R-RNO-379397); (R-RNO-379398); (R-RNO-379401); (R-RNO-442660)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "11994276;1502198;1765147;1948034;1948035;22722938;23161550;32963038;37186440;37298724;37321389;37509143;38650303;8125921", "class_list": "", "function": "Brain glucose metabolism and dopamine transporter changes in rats with morphine-induced conditioned place preference., [RefSeq, PubMed]; Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure. Publication Status: Online-Only, [RefSeq, PubMed]; Inheritance of wild and truncated DAT alleles from grand-parents: Opposite transgenerational consequences on the behavioral phenotype in adolescent DAT heterozygous rats., [RefSeq, PubMed]; Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1502198, PubMed:1765147, PubMed:1948034, PubMed:1948035, PubMed:8125921). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:8125921). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Pan-striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine-dependent incentive heroin seeking habits., [RefSeq, PubMed]; Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0005334 norepinephrine:sodium symporter activity;GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0015844 monoamine transport;GO:1990384 hyaloid vascular plexus regression;GO:0007626 locomotory behavior;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P23977-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24368-1", "uniprot_id": "PPIB_RAT", "mass": 23803.0, "length": 216, "protein_name": "Peptidyl-prolyl cis-trans isomerase B", "gene_name": "Ppib", "organism": "Rat", "refseq_name": "peptidyl-prolyl cis-trans isomerase B precursor", "refseq_ac": "NP_071981", "gene_names_uniprotkb": "Ppib", "gene_names_refseq": "CypB; Ppib; Scylp", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase B; 5.2.1.8; CYP-S1; Cyclophilin B; PPIase B; Rotamase B; S-cyclophilin; SCYLP", "protein_names_refseq": "CYP-S1; PPIase B; S-cyclophilin; S-cyclophylin; cyclophilin B; peptidyl-prolyl cis-trans isomerase B precursor; peptidyl-prolyl cis-trans isomerase B; rotamase B", "tax_id": 10116, "disease": "osteogenesis imperfecta type 9 (Disease Ontology:DOID:0110349)", "pathway": " (rno:64367); (R-RNO-1650814)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10775569;1530944;2194066;29967478;32908452;34502162", "class_list": "", "function": "Cyclophilin B in the hepatocyte proliferation.TMUB1 interfered with the binding of CAML to cyclophilin B in hepatocytes. Publication Status: Online-Only, [RefSeq, PubMed]; CypB-CD147 Signaling Is Involved in Crosstalk between Cartilage and FLS in Collagen-Induced Arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88541", "ec_number_list": "5.2.1.8;1.14.11.7", "go_molecular_function": "GO:0070063 RNA polymerase binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum", "go_biological_process": "GO:0044829 host-mediated activation of viral genome replication;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0060348 bone development;GO:0044794 host-mediated activation of viral process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P24368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04970-1", "uniprot_id": "RASN_RAT", "mass": 21243.0, "length": 189, "protein_name": "GTPase NRas", "gene_name": "Nras", "organism": "Rat", "refseq_name": "GTPase NRas", "refseq_ac": "NP_542944", "gene_names_uniprotkb": "Nras", "gene_names_refseq": "Nras", "protein_names_uniprotkb": "GTPase NRas; 3.6.5.2; Transforming protein N-Ras", "protein_names_refseq": "GTPase NRas; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; neuroblastoma ras oncogene; transforming protein N-Ras", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myelodysplastic syndrome (Disease Ontology:DOID:0050908); Noonan syndrome 3 (Disease Ontology:DOID:0060581); Noonan syndrome 6 (Disease Ontology:DOID:0060584); RASopathy (Disease Ontology:DOID:0080690); autoimmune lymphoproliferative syndrome type 4 (Disease Ontology:DOID:0110117); epidermal nevus (Disease Ontology:DOID:0111162); large congenital melanocytic nevus (Disease Ontology:DOID:0111359); linear nevus sebaceous syndrome (Disease Ontology:DOID:0111530); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); cancer (Disease Ontology:DOID:162); melanoma (Disease Ontology:DOID:1909); kidney cancer (Disease Ontology:DOID:263); transitional cell carcinoma (Disease Ontology:DOID:2671); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); papillary thyroid carcinoma (Disease Ontology:DOID:3969); cervical cancer (Disease Ontology:DOID:4362); hepatocellular carcinoma (Disease Ontology:DOID:684); liver carcinoma (Disease Ontology:DOID:686); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); cholangitis (Disease Ontology:DOID:9446); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:24605); (R-RNO-1169092); (R-RNO-1250347); (R-RNO-1433557); (R-RNO-171007); (R-RNO-179812); (R-RNO-180336); (R-RNO-186763); (R-RNO-1963640); (R-RNO-210993); (R-RNO-2179392); (R-RNO-2424491); (R-RNO-2871796); (R-RNO-375165); (R-RNO-5218921); (R-RNO-5621575); (R-RNO-5654688); (R-RNO-5654693); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5658442); (R-RNO-5673000); (R-RNO-5673001); (R-RNO-5674135); (R-RNO-5675221); (R-RNO-6798695); (R-RNO-8849471); (R-RNO-8851805); (R-RNO-9607240); (R-RNO-9634635); (R-RNO-9648002)", "pathway_count": 35, "publication_count": 5, "publication_id_list": "1714740;19319189;2105496;8313523;8344525", "class_list": "", "function": "Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KMB1", "ec_number_list": "3.6.5.2;2.7.10.1;3.1.3.48;2.7.11.1;2.7.1.153;2.7.1.137;7.6.2.1;2.3.2.27;3.6.1.1;3.6.5.-;3.6.5.3;3.4.26.1;3.1.2.22;3.6.5.5;2.7.10.2;3.6.1.5;2.7.11.17;2.7.11.13;2.7.11.24;3.4.21.73;2.7.10.4;2.7.12.2;3.1.3.16;3.6.4.-;1.1.1.-;2.7.11.22;3.1.2.-;3.1.4.4;2.5.1.58;2.5.1.59;3.4.24.81;3.6.1.-;2.7.11.25;3.6.5.4;3.2.1.20;2.7.1.91;2.3.1.-;2.1.1.100;3.2.1.31", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045766 positive regulation of angiogenesis;GO:0050852 T cell receptor signaling pathway;GO:0007265 Ras protein signal transduction;GO:0001938 positive regulation of endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04970-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6QI68-1", "uniprot_id": "PEN2_RAT", "mass": 12021.0, "length": 101, "protein_name": "Gamma-secretase subunit PEN-2", "gene_name": "Psenen", "organism": "Rat", "refseq_name": "gamma-secretase subunit PEN-2", "refseq_ac": "NP_001008764", "gene_names_uniprotkb": "Psenen", "gene_names_refseq": "Psenen; RGD1312037", "protein_names_uniprotkb": "Gamma-secretase subunit PEN-2; Liver regeneration-related protein LRRGT00140; Presenilin enhancer protein 2", "protein_names_refseq": "LRRGT00140 mRNA; gamma-secretase subunit PEN-2; liver regeneration-related protein LRRGT00140; presenilin enhancer 2 homolog; presenilin enhancer protein 2", "tax_id": 10116, "disease": "hidradenitis suppurativa (Disease Ontology:DOID:2280)", "pathway": " (rno:292788); (R-RNO-1251985); (R-RNO-193692); (R-RNO-205043); (R-RNO-3928665); (R-RNO-9013507); (R-RNO-9017802); (R-RNO-9839383)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "15456764;20236034;20333303", "class_list": "", "function": "Analysis of gamma-secretase cleavage of five substrates, APP, Notch1, N-cadherin, ephrinB and p75 neurotrophin receptor (p75-NTR) in membranes isolated from embryonic, young or old adult rat brains Publication Status: Online-Only, [RefSeq, PubMed]; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (By similarity). Besides its role in gamma-secretase complex, acts as a regulator of AMP-activated protein kinase (AMPK) activity in response to calorie restriction: binds metformin, an antidiabetic drug, promoting association with ATP6AP1, a subunit of the V-ATPase complex, leading to V-ATPase complex inhibition on lysosomes and AMPK activation via the AXIN1-STK11/LKB1 axis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Nicastrin, presenilin 1, APH-1, and PEN-2 form an active gamma-secretase complex expressed in mitochondria., [RefSeq, PubMed]; These results indicate that concerted differentiation of pancreatic precursor cell aggregates into functionally mature islet-like clusters can be achieved in poly(ethylene glycol)-based hydrogel cultures., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing;GO:0016485 protein processing;GO:0042982 amyloid precursor protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6QI68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53670-1", "uniprot_id": "LIMK2_RAT", "mass": 72202.0, "length": 638, "protein_name": "LIM domain kinase 2", "gene_name": "Limk2", "organism": "Rat", "refseq_name": "LIM domain kinase 2", "refseq_ac": "NP_077049", "gene_names_uniprotkb": "Limk2", "gene_names_refseq": "Limk2b; Limk2; Link2", "protein_names_uniprotkb": "LIM domain kinase 2; 2.7.11.1; LIMK-2", "protein_names_refseq": "LIM domain kinase 2; LIM motif-containing protein kinase 2; LIMK-2", "tax_id": 10116, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (rno:29524)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24561342;24962708;26438559;30870492;7651734", "class_list": "", "function": "Chronic inhibition of LIMK2 can improve cavernosal veno-occlusive dysfunction and ED by alleviating cavernosal fibrosis via normalizing the LIMK2/Cofilin pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that LIM motif-containing protein kinases LIMK1 and LIMK2-dependent acin rearrangement is involved in the development of complete Freund's adjuvant (CFA)-induced inflammatory pain. Publication Status: Online-Only, [RefSeq, PubMed]; ET-1 may be one of the upstream effectors for programmed neuronal necrosis through abnormal LIMK2 over-expression by ROCK1. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of LIMK2 expression and rescue of DRP1 function attenuates programmed necrotic neuronal death induced by status epilepticus., [RefSeq, PubMed]; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0006468 protein phosphorylation;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P53670-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYP1-1", "uniprot_id": "LRP4_RAT", "mass": 211880.0, "length": 1905, "protein_name": "Low-density lipoprotein receptor-related protein 4", "gene_name": "Lrp4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lrp4; Megf7", "gene_names_refseq": "", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 4; LRP-4; Multiple epidermal growth factor-like domains 7", "protein_names_refseq": "", "tax_id": 10116, "disease": "sclerosteosis 2 (Disease Ontology:DOID:0060757); bone development disease (Disease Ontology:DOID:0080006); Cenani-Lenz syndactyly syndrome (Disease Ontology:DOID:0090015); congenital myasthenic syndrome 17 (Disease Ontology:DOID:0110674)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "18848351;9693030", "class_list": "", "function": "Mediates SOST-dependent inhibition of bone formation (By similarity). Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling (By similarity). Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. Plays an essential role in the process of digit differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0034185 apolipoprotein binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0097104 postsynaptic membrane assembly;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0006897 endocytosis;GO:0050808 synapse organization;GO:0051124 synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QYP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62804-1", "uniprot_id": "H4_RAT", "mass": 11367.0, "length": 103, "protein_name": "Histone H4", "gene_name": "H4c16; H4c2; Hist1h4m", "organism": "Rat", "refseq_name": "histone H4", "refseq_ac": "NP_001116941", "gene_names_uniprotkb": "H4c16; H4c2; Hist1h4m; H4f16; H4ft; Hist1h4b; Hist4h4; Hist4", "gene_names_refseq": "H4c14; H4c16; H4c2; H4f16; Hist2h4; Hist4h4", "protein_names_uniprotkb": "Histone H4", "protein_names_refseq": "histone 2, H4; histone H4; histone cluster 2, H4", "tax_id": 10116, "disease": "", "pathway": " (rno:291152); (rno:295277); (rno:64627); (R-RNO-110330); (R-RNO-110331); (R-RNO-212300); (R-RNO-2299718); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559586); (R-RNO-3214815); (R-RNO-3214841); (R-RNO-3214842); (R-RNO-3214847); (R-RNO-3214858); (R-RNO-427359); (R-RNO-427413); (R-RNO-4551638); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-5625886); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-606279); (R-RNO-68616); (R-RNO-69473); (R-RNO-73728); (R-RNO-73772); (R-RNO-8936459); (R-RNO-9018519); (R-RNO-9764725); (R-RNO-9841922); (R-RNO-9843940); (R-RNO-9843970); (R-RNO-9909649); (R-RNO-9940951); (R-RNO-9943411); (R-RNO-9943962); (R-RNO-9970672)", "pathway_count": 40, "publication_count": 14, "publication_id_list": "10318873;1582415;16042990;16641100;1706721;19343714;22673903;2920170;34502162;3691674;38843836;41549750;5171427;7932740", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Stimulates osteogenesis and hematopoiesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02304;P02305;Q5BM23;Q7M0E8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0032991 protein-containing complex;GO:0000786 nucleosome", "go_biological_process": "GO:0030154 cell differentiation;GO:0006334 nucleosome assembly;GO:0045653 negative regulation of megakaryocyte differentiation;GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P62804-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00715-1", "uniprot_id": "H2B1_RAT", "mass": 13990.0, "length": 125, "protein_name": "Histone H2B type 1", "gene_name": "", "organism": "Rat", "refseq_name": "histone H2B type 1", "refseq_ac": "NP_072173", "gene_names_uniprotkb": "", "gene_names_refseq": "H2b; Hist1h2bg; Hist1h2bl", "protein_names_uniprotkb": "Histone H2B type 1", "protein_names_refseq": "histone 1, H2bl; histone 2b; histone H2B type 1; histone cluster 1, H2bl", "tax_id": 10116, "disease": "", "pathway": " (rno:64647)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16283522;2011515;34502162;3666307;38580378", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid (By similarity)., [UniProtKB]; Monoubiquitination of histone H2B is a crucial regulator of the transcriptome during memory formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q00715-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00728-1", "uniprot_id": "H2A4_RAT", "mass": 14284.0, "length": 130, "protein_name": "Histone H2A type 4", "gene_name": "", "organism": "Rat", "refseq_name": "histone H2A type 4", "refseq_ac": "NP_068611", "gene_names_uniprotkb": "", "gene_names_refseq": "H2ac1; Hist1h2aa; Th2a", "protein_names_uniprotkb": "Histone H2A type 4; Histone H2A, testis; TH2A", "protein_names_refseq": "histone H2A type 4; histone H2A, testis; histone cluster 1 H2A family member a; histone cluster 1, H2aa; testis-specific histone 2a", "tax_id": 10116, "disease": "", "pathway": " (rno:24828); (R-RNO-110330); (R-RNO-110331); (R-RNO-212300); (R-RNO-2299718); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559586); (R-RNO-3214815); (R-RNO-3214858); (R-RNO-427359); (R-RNO-427413); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-5625886); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-5689901); (R-RNO-606279); (R-RNO-68616); (R-RNO-73728); (R-RNO-73772); (R-RNO-8936459); (R-RNO-9018519); (R-RNO-9764725); (R-RNO-9841922); (R-RNO-9843940); (R-RNO-9843970); (R-RNO-9909649); (R-RNO-9940951); (R-RNO-9943411); (R-RNO-9943962); (R-RNO-9970672)", "pathway_count": 33, "publication_count": 3, "publication_id_list": "2011515;27693081;28263745", "class_list": "", "function": "Animal physical conditioning increases hyper-acetylation of histones and increased the expression of NRF-1 and MEF2A genes., [RefSeq, PubMed]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Data indicate the effect of angiotensin II receptors' blockade on the macrophage infiltration and histone modifications occurring at the promoter region of monocyte chemoattractant protein (MCP-1) and transforming growth factor-beta (TGF-beta1)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0006325 chromatin organization;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q00728-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4FZT6-1", "uniprot_id": "H2A3_RAT", "mass": 14121.0, "length": 130, "protein_name": "Histone H2A type 3", "gene_name": "H2ac25", "organism": "Rat", "refseq_name": "histone H2A type 3", "refseq_ac": "NP_068612", "gene_names_uniprotkb": "H2ac25; Hist3h2a", "gene_names_refseq": "H2ac25; H2a; Hist3h2a", "protein_names_uniprotkb": "Histone H2A type 3; H2A-clustered histone 25; Histone cluster 3, H2a", "protein_names_refseq": "histone 2a; histone 3, H2a; histone H2A type 3; histone cluster 3, H2a", "tax_id": 10116, "disease": "", "pathway": " (rno:64646); (R-RNO-3214815); (R-RNO-3214858); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-5689901)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "12097138;26899247;34502162", "class_list": "", "function": "Akt-mediated H2A phosphorylation has an anti-apoptotic function in conditions of H2O2-induced oxidative stress in neurons and PC12 cells. Publication Status: Online-Only, [RefSeq, PubMed]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; The results demonstrate that histone 2A stimulates glucose-6-phosphatase activity by permeabilizing the microsomal membrane., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0006337 nucleosome disassembly;GO:0070914 UV-damage excision repair;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4FZT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64598-1", "uniprot_id": "H2A1F_RAT", "mass": 14176.0, "length": 130, "protein_name": "Histone H2A type 1-F", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H2A type 1-F", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2011515", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0006325 chromatin organization;GO:0006337 nucleosome disassembly;GO:0070914 UV-damage excision repair;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64598-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A3T0-1", "uniprot_id": "D4A3T0_RAT", "mass": 151093.0, "length": 1319, "protein_name": "SOS Ras/Rac guanine nucleotide exchange factor 1", "gene_name": "Sos1", "organism": "Rat", "refseq_name": "son of sevenless homolog 1", "refseq_ac": "NP_001094186", "gene_names_uniprotkb": "Sos1", "gene_names_refseq": "Sos1", "protein_names_uniprotkb": "SOS Ras/Rac guanine nucleotide exchange factor 1", "protein_names_refseq": "son of sevenless homolog 1", "tax_id": 10116, "disease": "gingival fibromatosis (Disease Ontology:DOID:0060466); Noonan syndrome 4 (Disease Ontology:DOID:0060582); prostate cancer (Disease Ontology:DOID:10283); atrial heart septal defect (Disease Ontology:DOID:1882); brain ischemia (Disease Ontology:DOID:2316); Noonan syndrome (Disease Ontology:DOID:3490); cerebral infarction (Disease Ontology:DOID:3526); cervical cancer (Disease Ontology:DOID:4362); pulmonary valve stenosis (Disease Ontology:DOID:6420)", "pathway": " (rno:313845); (R-RNO-112412); (R-RNO-1250347); (R-RNO-1433557); (R-RNO-1433559); (R-RNO-167044); (R-RNO-179812); (R-RNO-180336); (R-RNO-186763); (R-RNO-193648); (R-RNO-1963640); (R-RNO-210993); (R-RNO-2179392); (R-RNO-2424491); (R-RNO-2428933); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-354194); (R-RNO-375165); (R-RNO-416482); (R-RNO-5654688); (R-RNO-5654693); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5673001); (R-RNO-74749); (R-RNO-74751); (R-RNO-8851805); (R-RNO-8853659); (R-RNO-8983432); (R-RNO-9013149); (R-RNO-9028731); (R-RNO-912526); (R-RNO-9607240); (R-RNO-983695); (R-RNO-9842663)", "pathway_count": 41, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0033081 regulation of T cell differentiation in thymus;GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0002260 lymphocyte homeostasis;GO:0007296 vitellogenesis;GO:0002931 response to ischemia", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A3T0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A930-1", "uniprot_id": "D4A930_RAT", "mass": 107700.0, "length": 1017, "protein_name": "Mastermind-like transcriptional coactivator 1", "gene_name": "Maml1", "organism": "Rat", "refseq_name": "mastermind-like protein 1", "refseq_ac": "NP_001388485", "gene_names_uniprotkb": "Maml1", "gene_names_refseq": "Maml1", "protein_names_uniprotkb": "Mastermind-like transcriptional coactivator 1", "protein_names_refseq": "mastermind like 1; mastermind-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:303101); (R-RNO-350054); (R-RNO-8941856)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0002193 MAML1-RBP-Jkappa- ICN1 complex;GO:1990433 CSL-Notch-Mastermind transcription factor complex", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A930-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LZX9-1", "uniprot_id": "F1LZX9_RAT", "mass": 115095.0, "length": 1043, "protein_name": "Integrin alpha-V", "gene_name": "Itgav", "organism": "Rat", "refseq_name": "integrin alpha-V isoform 1 precursor", "refseq_ac": "NP_001385621", "gene_names_uniprotkb": "Itgav", "gene_names_refseq": "Cd51; Itgav", "protein_names_uniprotkb": "Integrin alpha-V; Vitronectin receptor subunit alpha", "protein_names_refseq": "Dnmt3l-ps1 pseudogene; integrin alpha-V isoform 1 precursor; integrin alpha-V", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); corneal neovascularization (Disease Ontology:DOID:11382); ischemia (Disease Ontology:DOID:326); hyperglycemia (Disease Ontology:DOID:4195); coronary stenosis (Disease Ontology:DOID:4248); abdominal aortic aneurysm (Disease Ontology:DOID:7693); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (R-RNO-1236973); (R-RNO-1566948); (R-RNO-210990); (R-RNO-2129379); (R-RNO-216083); (R-RNO-2173789); (R-RNO-3000170); (R-RNO-3000178); (R-RNO-4420097); (R-RNO-445144); (R-RNO-6798695); (R-RNO-9860927)", "pathway_count": 12, "publication_count": 6, "publication_id_list": "22673903;24090084;29210651;30541573;31010681;38843836", "class_list": "", "function": "Findings demonstrate that, in SI-treated rats, oxidative stress activates STAT3 signaling which up-regulates miR-25 expression, in a very early stage. The increased miR-25 then inhibits ITGAV and PEDF expressions, resulting in RPE phagocytosis dysfunction and then RPE apoptosis and visual impairment as observed in patients with AMD., [RefSeq, PubMed]; Integrin alphavbeta5 which induces LSECs dysfunction, promoting hepatic sinusoidal capillarization regulates VN expression via ERK/FAK pathway under high glucose/ox-LDL, [RefSeq, PubMed]; The effects on cardiac fibroblasts , isolated by spontaneously hypertensive rats (SHR), of integrin alphanubeta5 inhibition in myofibroblast differentiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0046872 metal ion binding;GO:1990430 extracellular matrix protein binding;GO:0038132 neuregulin binding;GO:0002020 protease binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0034683 integrin alphav-beta3 complex;GO:0034684 integrin alphav-beta5 complex;GO:0034685 integrin alphav-beta6 complex;GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion;GO:0033627 cell adhesion mediated by integrin;GO:0043277 apoptotic cell clearance;GO:0051057 positive regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "F1LZX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1M6Q3-1", "uniprot_id": "F1M6Q3_RAT", "mass": 167136.0, "length": 1707, "protein_name": "Collagen type IV alpha 2 chain", "gene_name": "Col4a2", "organism": "Rat", "refseq_name": "collagen alpha-2(IV) chain precursor", "refseq_ac": "NP_001414185", "gene_names_uniprotkb": "Col4a2", "gene_names_refseq": "Col4a2", "protein_names_uniprotkb": "Collagen type IV alpha 2 chain", "protein_names_refseq": "alpha-2 collagen type IV; collagen alpha-2(IV) chain precursor; collagen alpha-2(IV) chain; collagen, type IV, alpha 2; procollagen, type IV, alpha 2", "tax_id": 10116, "disease": "porencephaly (Disease Ontology:DOID:0060263); autosomal recessive brain small vessel disease 2B (Disease Ontology:DOID:0061233); autosomal dominant brain small vessel disease 2A (Disease Ontology:DOID:0112314); severe pre-eclampsia (Disease Ontology:DOID:13129); uterine fibroid (Disease Ontology:DOID:13223); atherosclerosis (Disease Ontology:DOID:1936); myopathy (Disease Ontology:DOID:423); collagen disease (Disease Ontology:DOID:854)", "pathway": " (rno:306628); (R-RNO-1442490); (R-RNO-1566977); (R-RNO-1650814); (R-RNO-186797); (R-RNO-2022090); (R-RNO-216083); (R-RNO-2243919); (R-RNO-3000157); (R-RNO-3000171); (R-RNO-419037)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "31285761;32947968", "class_list": "", "function": "Decreased Expression of Canstatin in Rat Model of Monocrotaline-Induced Pulmonary Arterial Hypertension: Protective Effect of Canstatin on Right Ventricular Remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Wnt/beta-catenin pathway was found to play an important role in the negative regulation of osteogenesis through COL4A2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005587 collagen type IV trimer;GO:0005581 collagen trimer", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030198 extracellular matrix organization;GO:0014823 response to activity;GO:0016525 negative regulation of angiogenesis;GO:0071560 cellular response to transforming growth factor beta stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1M6Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01177-1", "uniprot_id": "PLMN_RAT", "mass": 90536.0, "length": 812, "protein_name": "Plasminogen", "gene_name": "Plg", "organism": "Rat", "refseq_name": "plasminogen precursor", "refseq_ac": "NP_445943", "gene_names_uniprotkb": "Plg", "gene_names_refseq": "Ab1-346; Plg", "protein_names_uniprotkb": "Plasminogen", "protein_names_refseq": "plasminogen precursor", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); plasminogen deficiency type I (Disease Ontology:DOID:0111592); osteonecrosis (Disease Ontology:DOID:10159); hereditary angioedema (Disease Ontology:DOID:14735); thrombophilia (Disease Ontology:DOID:2452); Noonan syndrome (Disease Ontology:DOID:3490); conjunctivitis (Disease Ontology:DOID:6195)", "pathway": " (rno:85253); (R-RNO-114608); (R-RNO-1592389); (R-RNO-186797); (R-RNO-381426); (R-RNO-75205)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "1645711;212205;21454685;29767556;38101751;965386", "class_list": "", "function": "Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo., [UniProtKB, UniProtKB, UniProtKB]; Has an antiangiogenic activity and inhibits neovascularization. Could act through the inhibition of the ATP synthase subunit ATP5F1A., [UniProtKB, UniProtKB]; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protease which primary function is to degrade fibrin, the main component of blood clots. Also cleaves other components of blood clots like thrombospondin-1/THBS1 and von Willebrand factor/VWF. Can also directly and/or through the activation of other proteases degrade the various components of the extracellular matrix including collagen, fibronectin and laminin. Thereby, regulates a variety of biological processes including embryonic development, tissue remodeling, and inflammation (By similarity). In ovulation, weakens the walls of the Graafian follicle (PubMed:212205, PubMed:965386). In vitro, it is also able to cleave several complement zymogens, such as C1, C4 and C5 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Proteoform-Resolved Profiling of Plasminogen Activation Reveals Novel Abundant Phosphorylation Site and Primary N-Terminal Cleavage Site., [RefSeq, PubMed]; The presence of active plasmin in urine in hydronephrosis could cause abnormal proteolytic activation of ENaC-gamma and impaired ability to excrete Na via NCC., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKB6;Q9R0W3", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0022617 extracellular matrix disassembly;GO:0046716 muscle cell cellular homeostasis;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q01177-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BK06-1", "uniprot_id": "CCDB1_RAT", "mass": 39066.0, "length": 355, "protein_name": "Cyclin-D1-binding protein 1", "gene_name": "Ccndbp1", "organism": "Rat", "refseq_name": "cyclin-D1-binding protein 1", "refseq_ac": "NP_001013222", "gene_names_uniprotkb": "Ccndbp1", "gene_names_refseq": "Ccndbp1", "protein_names_uniprotkb": "Cyclin-D1-binding protein 1", "protein_names_refseq": "cyclin D-type binding-protein 1; cyclin-D1-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362201)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10915743", "class_list": "", "function": "May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3KR56-1", "uniprot_id": "ASTRA_RAT", "mass": 80684.0, "length": 723, "protein_name": "Protein Aster-A", "gene_name": "Gramd1a", "organism": "Rat", "refseq_name": "protein Aster-A isoform 2", "refseq_ac": "NP_001014182", "gene_names_uniprotkb": "Gramd1a", "gene_names_refseq": "Eg1rvc; Gramd1a; RGD1311022", "protein_names_uniprotkb": "Protein Aster-A; EG1RVC; GRAM domain-containing protein 1A", "protein_names_refseq": "GRAM domain-containing protein 1A; protein Aster-A isoform 2; protein Aster-A", "tax_id": 10116, "disease": "", "pathway": " (rno:361550)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15033532", "class_list": "", "function": "Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome. This function in autophagy requires its cholesterol-transfer activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6Y8E7", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0071397 cellular response to cholesterol;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KR56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2L4T2-1", "uniprot_id": "PAX9_RAT", "mass": 36379.0, "length": 342, "protein_name": "Paired box protein Pax-9", "gene_name": "Pax9", "organism": "Rat", "refseq_name": "paired box protein Pax-9", "refseq_ac": "NP_001034628", "gene_names_uniprotkb": "Pax9", "gene_names_refseq": "Pax9", "protein_names_uniprotkb": "Paired box protein Pax-9", "protein_names_refseq": "paired box gene 9; paired box protein Pax-9", "tax_id": 10116, "disease": "tooth agenesis (Disease Ontology:DOID:0050591)", "pathway": " (rno:362741)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17412341", "class_list": "", "function": "Calcitonin gene expression could be directly activated by Nkx2.1, whereas Pax9 is not involved in transcription from the 2kbp calcitonin promoter, [RefSeq, PubMed]; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2L4T2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58195-1", "uniprot_id": "PLS1_RAT", "mass": 36711.0, "length": 335, "protein_name": "Phospholipid scramblase 1", "gene_name": "Plscr1; Plscr2", "organism": "Rat", "refseq_name": "phospholipid scramblase 1 isoform 1", "refseq_ac": "NP_476542", "gene_names_uniprotkb": "Plscr1; Plscr2; Plscr2", "gene_names_refseq": "Plscr1", "protein_names_uniprotkb": "Phospholipid scramblase 1; 3.1.-.-; Ca(2+)-dependent phospholipid scramblase 1; Mg(2+)-dependent nuclease; PL scramblase 1", "protein_names_refseq": "PL scramblase 1; ca(2+)-dependent phospholipid scramblase 1; mg(2+)-dependent nuclease; phospholipid scramblase 1 isoform 1; phospholipid scramblase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:117540)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11259432;25289695", "class_list": "", "function": "Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific distribution of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (By similarity). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (By similarity). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (By similarity). May contribute to cytokine-regulated cell proliferation and differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study reveals a complex regulation for PLSCR1 tyrosine phosphorylation in FcepsilonRI-activated mast cells, and that PLSCR1 sits at a crossroads between Lyn and Fyn pathways. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.-.-;1.6.5.5", "go_molecular_function": "GO:0032791 lead ion binding;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway;GO:0006955 immune response;GO:0010288 response to lead ion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58195-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499V3-1", "uniprot_id": "RAD9B_RAT", "mass": 44075.0, "length": 398, "protein_name": "Cell cycle checkpoint control protein RAD9B", "gene_name": "Rad9b", "organism": "Rat", "refseq_name": "cell cycle checkpoint control protein RAD9B", "refseq_ac": "NP_001025213", "gene_names_uniprotkb": "Rad9b", "gene_names_refseq": "Rad9b", "protein_names_uniprotkb": "Cell cycle checkpoint control protein RAD9B; DNA repair exonuclease rad9 homolog B", "protein_names_refseq": "DNA repair exonuclease rad9 homolog B; cell cycle checkpoint control protein RAD9B homolog; cell cycle checkpoint control protein RAD9B", "tax_id": 10116, "disease": "", "pathway": " (rno:363924); (R-RNO-176187); (R-RNO-5685938); (R-RNO-5693607); (R-RNO-6804756); (R-RNO-69473)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "37460044", "class_list": "", "function": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity., [UniProtKB, UniProtKB]; Expression of RAD9B in the mesostriatal system of rats and humans: Overexpression in a 6-OHDA rat model of Parkinson's disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0030896 checkpoint clamp complex", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0071479 cellular response to ionizing radiation;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499V3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVJ3-1", "uniprot_id": "PLPP7_RAT", "mass": 29768.0, "length": 271, "protein_name": "Inactive phospholipid phosphatase 7", "gene_name": "Plpp7", "organism": "Rat", "refseq_name": "inactive phospholipid phosphatase 7", "refseq_ac": "NP_001012349", "gene_names_uniprotkb": "Plpp7; Ppapdc3", "gene_names_refseq": "Plpp7; Ppapdc3; RGD1305821", "protein_names_uniprotkb": "Inactive phospholipid phosphatase 7; Phosphatidic acid phosphatase type 2 domain-containing protein 3", "protein_names_refseq": "inactive phospholipid phosphatase 7; phosphatidic acid phosphatase type 2 domain containing 3; phosphatidic acid phosphatase type 2 domain-containing protein 3; probable lipid phosphate phosphatase PPAPDC3", "tax_id": 10116, "disease": "", "pathway": " (rno:296635)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010832 negative regulation of myotube differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70498-1", "uniprot_id": "PLD2_RAT", "mass": 106037.0, "length": 933, "protein_name": "Phospholipase D2", "gene_name": "Pld2", "organism": "Rat", "refseq_name": "phospholipase D2", "refseq_ac": "NP_150641", "gene_names_uniprotkb": "Pld2", "gene_names_refseq": "Pld2; Pldc", "protein_names_uniprotkb": "Phospholipase D2; 3.1.4.4; Choline phosphatase 2; PLD 2; PLD1C; Phosphatidylcholine-hydrolyzing phospholipase D2; rPLD2", "protein_names_refseq": "PLD 2; PLD1C; choline phosphatase 2; phosphatidylcholine-hydrolyzing phospholipase D2; phospholipase D gene 2; phospholipase D2; rPLD2", "tax_id": 10116, "disease": "developmental cardiac valvular defect (Disease Ontology:DOID:0080633); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:25097); (R-RNO-1483166); (R-RNO-2029485); (R-RNO-9013149); (R-RNO-9013404)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "15282299;18625302;21414324;21525000;22344748;29393594;29526688;30207376;37249288;8753790;9111050;9533024", "class_list": "", "function": "Function as phospholipase selective for phosphatidylcholine (By similarity) (PubMed:15282299, PubMed:9111050). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) (PubMed:15282299)., [UniProtKB, PubMed, UniProtKB, PubMed]; Function as phospholipase selective for phosphatidylcholine. May have a role in signal-induced cytoskeletal regulation and/or endocytosis., [UniProtKB, UniProtKB, UniProtKB]; Increased expression of both Pld1 and Pld2 occurs simultaneously with the appearance of vascular calcification in chronic kidney disease., [RefSeq, PubMed]; New insights in the intricate way PLD and mTOR cooperate to control myogenesis, [RefSeq, PubMed]; PLD2 toxicity is due to its lipase activity. Overexpression of a catalytically inactive mutant (K758R) of PLD2 prevents the loss of dopaminergic neurons in the substantia nigra pars compacta and does not show signs of toxicity after 10weeks of overexpression. Mutant K758R does not affect dopamine levels in the striatum., [RefSeq, PubMed]; Phosphatidic acid produced by PLD2 plays an important role in regulating cell morphology in mast cells., [RefSeq, PubMed]; Phospholipase D2 targeted by miR-5132-5p alleviates cerulein-induced acute pancreatitis via the Nrf2/NFkappaB pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08768", "ec_number_list": "2.7.11.1;2.7.1.153;2.7.1.137;2.7.10.2;3.1.16.1;2.7.10.1;3.6.5.2;2.7.11.13;3.1.4.4;2.3.1.-;3.1.4.39;1.6.3.-", "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0005080 protein kinase C binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0031410 cytoplasmic vesicle;GO:0005901 caveola;GO:0042383 sarcolemma", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0030335 positive regulation of cell migration;GO:0031175 neuron projection development;GO:0035556 intracellular signal transduction;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P70498-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35286-1", "uniprot_id": "RAB13_RAT", "mass": 22901.0, "length": 203, "protein_name": "Ras-related protein Rab-13", "gene_name": "Rab13", "organism": "Rat", "refseq_name": "ras-related protein Rab-13", "refseq_ac": "NP_112354", "gene_names_uniprotkb": "Rab13", "gene_names_refseq": "Rab13", "protein_names_uniprotkb": "Ras-related protein Rab-13; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-13", "tax_id": 10116, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167)", "pathway": " (rno:81756); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "1313420;19074001;20008558;21041651;22562557;23419316;23772379;26538022;29247648;33527312", "class_list": "", "function": "Findings suggest that MICAL-L2 is an effector of insulin-activated Rab13, which links to GLUT4 through ACTN4, localizing GLUT4 vesicles at the muscle cell periphery to enable their fusion with the membrane., [RefSeq, PubMed]; In summary, ionomycin-promoted exocytosis of GLUT4 is partly reversed by siPKCtheta;, whereas ionomycin-inhibited endocytosis of GLUT4 requires both siPKCalpha and siPKCtheta;. PKCalpha and PKCtheta; contribute to ionomycin-induced phosphorylation of AS160 and TBC1D1. Rab13 is required for ionomycin-regulated GLUT4 exocytosis., [RefSeq, PubMed]; Rab13 and Desmosome Redistribution in Uterine Epithelial Cells During Early Pregnancy., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3X5", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;2.5.1.60;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0015031 protein transport;GO:0031175 neuron projection development;GO:0032869 cellular response to insulin stimulus;GO:0072659 protein localization to plasma membrane;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P35286-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29315-1", "uniprot_id": "RINI_RAT", "mass": 49974.0, "length": 456, "protein_name": "Ribonuclease inhibitor", "gene_name": "Rnh1", "organism": "Rat", "refseq_name": "ribonuclease inhibitor isoform a", "refseq_ac": "NP_001257691", "gene_names_uniprotkb": "Rnh1; LOC100360501; Rnh", "gene_names_refseq": "Rnh1; Rnh", "protein_names_uniprotkb": "Ribonuclease inhibitor; Ribonuclease/angiogenin inhibitor 1", "protein_names_refseq": "ribonuclease inhibitor isoform a; ribonuclease inhibitor", "tax_id": 10116, "disease": "", "pathway": " (rno:100360501)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1536887;23624614;24288130", "class_list": "", "function": "RNH1 protein is upregulated after spinal cord injury., [RefSeq, PubMed]; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:1536887). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (By similarity). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (By similarity)., [UniProtKB, UniProtKB, PubMed]; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress. Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rnh1-mediated RhoA inactivation enhances the differentiation and myelination in oligodendrocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRS9", "ec_number_list": "", "go_molecular_function": "GO:0008428 ribonuclease inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation;GO:0045765 regulation of angiogenesis;GO:0036416 tRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P29315-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35427-1", "uniprot_id": "RL13A_RAT", "mass": 23476.0, "length": 203, "protein_name": "Large ribosomal subunit protein uL13", "gene_name": "Flt3lg; Rpl13a", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Flt3lg; Rpl13a; Flt3lg; Rpl13a-ps8; Rpl13a", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein uL13; 60S ribosomal protein L13a", "protein_names_refseq": "", "tax_id": 10116, "disease": "immunodeficiency 125 (Disease Ontology:DOID:0061091); aplastic anemia (Disease Ontology:DOID:12449); Fanconi anemia (Disease Ontology:DOID:13636); colon carcinoma (Disease Ontology:DOID:1520); pancreatic cancer (Disease Ontology:DOID:1793); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); myelofibrosis (Disease Ontology:DOID:4971); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "8119894", "class_list": "", "function": "Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0005840 ribosome;GO:0022626 cytosolic ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0032496 response to lipopolysaccharide;GO:0071320 cellular response to cAMP;GO:0017148 negative regulation of translation;GO:0042592 homeostatic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35427-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVR3-1", "uniprot_id": "CD302_RAT", "mass": 25452.0, "length": 228, "protein_name": "CD302 antigen", "gene_name": "Cd302", "organism": "Rat", "refseq_name": "CD302 antigen precursor", "refseq_ac": "NP_001013938", "gene_names_uniprotkb": "Cd302; Clec13a", "gene_names_refseq": "Cd302; RGD1307606", "protein_names_uniprotkb": "CD302 antigen; C-type lectin domain family 13 member A", "protein_names_refseq": "C-type lectin domain family 13 member A; CD302 antigen precursor; CD302 antigen; type I transmembrane C-type lectin receptor DCL-1", "tax_id": 10116, "disease": "", "pathway": " (rno:295629)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17947679", "class_list": "", "function": "HDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis but also in cell adhesion and migration, [RefSeq, PubMed]; Multifunctional C-type lectin receptor involved in endocytosis, phagocytosis and regulation of cell adhesion and migration. Plays a critical role in guiding dendritic cells to lymph nodes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005938 cell cortex;GO:0016020 membrane;GO:0030175 filopodium;GO:0005902 microvillus", "go_biological_process": "GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499N3-1", "uniprot_id": "WDR18_RAT", "mass": 47225.0, "length": 431, "protein_name": "WD repeat-containing protein 18", "gene_name": "Wdr18", "organism": "Rat", "refseq_name": "WD repeat-containing protein 18", "refseq_ac": "NP_001034116", "gene_names_uniprotkb": "Wdr18", "gene_names_refseq": "Wdr18", "protein_names_uniprotkb": "WD repeat-containing protein 18", "protein_names_refseq": "WD repeat-containing protein 18", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:314617); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). May play a role during development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005656 nuclear pre-replicative complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0006364 rRNA processing;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499N3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57760-1", "uniprot_id": "STK16_RAT", "mass": 34409.0, "length": 305, "protein_name": "Serine/threonine-protein kinase 16", "gene_name": "Stk16", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase 16", "refseq_ac": "NP_775165", "gene_names_uniprotkb": "Stk16; Mpsk1; Tsf1", "gene_names_refseq": "F52; PKL12; Stk16", "protein_names_uniprotkb": "Serine/threonine-protein kinase 16; 2.7.10.2; 2.7.11.1; MPSK; Myristoylated and palmitoylated serine/threonine-protein kinase; Protein kinase PKL12; TGF-beta-stimulated factor 1; TSF-1; Tyrosine-protein kinase STK16", "protein_names_refseq": "MPSK; TGF-beta-stimulated factor 1; TSF-1; myristoylated and palmitoylated serine/threonine-protein kinase; protein kinase PKL12; serine/threonine-protein kinase 16; tyrosine-protein kinase STK16", "tax_id": 10116, "disease": "", "pathway": " (rno:286927)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10947953;16310770", "class_list": "", "function": "Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins., [UniProtKB]; The STK16 overexpression in several cell lines enhances their capacity to produce and secrete VEGF., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.10.1;2.7.1.153;2.7.1.137;2.7.10.2;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.10.4;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;2.7.1.32;2.7.1.82;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046777 protein autophosphorylation;GO:0071560 cellular response to transforming growth factor beta stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P57760-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4G073-1", "uniprot_id": "TRDMT_RAT", "mass": 44070.0, "length": 391, "protein_name": "tRNA (cytosine(38)-C(5))-methyltransferase", "gene_name": "Trdmt1", "organism": "Rat", "refseq_name": "tRNA (cytosine(38)-C(5))-methyltransferase", "refseq_ac": "NP_001026813", "gene_names_uniprotkb": "Trdmt1; Dnmt2", "gene_names_refseq": "Dnmt2; Trdmt1", "protein_names_uniprotkb": "tRNA (cytosine(38)-C(5))-methyltransferase; 2.1.1.204; DNA (cytosine-5)-methyltransferase-like protein 2; Dnmt2", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase-like protein 2; DNA methyltransferase 2; tRNA (cytosine(38)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:291324)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35474613", "class_list": "", "function": "Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Has higher activity on tRNA(Asp) modified with queuosine at position 34., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-kappaB/MAPK-TNF-alpha pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.204", "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0016428 tRNA (cytidine-5-)-methyltransferase activity;GO:0003723 RNA binding;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008033 tRNA processing;GO:0001975 response to amphetamine;GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0036416 tRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4G073-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38983-1", "uniprot_id": "RSSA_RAT", "mass": 32824.0, "length": 295, "protein_name": "Small ribosomal subunit protein uS2", "gene_name": "Rpsa", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS2", "refseq_ac": "NP_058834", "gene_names_uniprotkb": "Rpsa; Lamr1", "gene_names_refseq": "Lamr1; Rpsa", "protein_names_uniprotkb": "Small ribosomal subunit protein uS2; 37 kDa laminin receptor precursor; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; LBP/p40; LRP/LR; LamR; Laminin receptor 1; Laminin-binding protein precursor p40", "protein_names_refseq": "laminin receptor 1 (67kD, ribosomal protein SA); laminin receptor 1 (ribosomal protein SA); small ribosomal subunit protein uS2", "tax_id": 10116, "disease": "arrhythmogenic right ventricular dysplasia 5 (Disease Ontology:DOID:0110074); sciatic neuropathy (Disease Ontology:DOID:11446); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:29236); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 13, "publication_id_list": "15548204;16453457;18047804;21454685;24508265;31795399;32664509;34502162;41549750;8076763;8119397;8910435;925037", "class_list": "", "function": "Blockade of 67-kDa Laminin Receptor Facilitates AQP4 Down-Regulation and BBB Disruption via ERK1/2-and p38 MAPK-Mediated PI3K/AKT Activations. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that green tea polyphenols (GTPP)-induced potentiation of brain-derived neurotrophic factor (BDNF) action required the cell-surface associated 67 kDa laminin receptor (67LR)., [RefSeq, PubMed]; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA., [UniProtKB, PubMed, HAMAP]; These findings suggested that 67-kDa laminin receptor expression level might be involved in Blood-Brain Barrier integrity in regional specific manners, which might affect the susceptibility to Status Epilepticus induction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6ZB78", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0043236 laminin binding;GO:0043022 ribosome binding;GO:0005055 laminin receptor activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0098609 cell-cell adhesion;GO:0002181 cytoplasmic translation;GO:0000028 ribosomal small subunit assembly;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38983-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QSK2-1", "uniprot_id": "TM11G_RAT", "mass": 46593.0, "length": 417, "protein_name": "Transmembrane protease serine 11G", "gene_name": "Tmprss11g", "organism": "Rat", "refseq_name": "transmembrane protease serine 11G", "refseq_ac": "NP_001008554", "gene_names_uniprotkb": "Tmprss11g; Desc4", "gene_names_refseq": "Desc4; RGD1306446; Tmprss11g", "protein_names_uniprotkb": "Transmembrane protease serine 11G; 3.4.21.-; Serine protease DESC4", "protein_names_refseq": "serine protease Desc4; transmembrane protease serine 11G", "tax_id": 10116, "disease": "", "pathway": " (rno:289546)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15558215;19149666", "class_list": "", "function": "The identified cleavage-sites are typical for trypsin-like serine proteases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NJM5", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5QSK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P86182-1", "uniprot_id": "CCD22_RAT", "mass": 70855.0, "length": 627, "protein_name": "Coiled-coil domain-containing protein 22", "gene_name": "Ccdc22", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 22", "refseq_ac": "NP_001129309", "gene_names_uniprotkb": "Ccdc22", "gene_names_refseq": "Ccdc22; RGD1560910", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 22", "protein_names_refseq": "coiled-coil domain containing 22; coiled-coil domain-containing protein 22", "tax_id": 10116, "disease": "Ritscher-Schinzel syndrome 2 (Disease Ontology:DOID:0060572)", "pathway": " (rno:317381); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the Commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (By similarity). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (By similarity). Involved in regulation of NF-kappa-B signaling (By similarity). Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex (By similarity). May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (By similarity). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (By similarity). Plays a role in copper ion homeostasis (By similarity). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6KP98", "ec_number_list": "", "go_molecular_function": "GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005813 centrosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0015031 protein transport;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P86182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62850-1", "uniprot_id": "RS24_RAT", "mass": 15423.0, "length": 133, "protein_name": "Small ribosomal subunit protein eS24", "gene_name": "Rps24-ps17; Rps24l3; Rps24l7; Rps24", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS24", "refseq_ac": "NP_112374", "gene_names_uniprotkb": "Rps24-ps17; Rps24l3; Rps24l7; Rps24; RGD1564325; Rps24-ps15; Rps24-ps18; Rps24-ps19; Rps24l2; Rps24l3; Rps24l4; Rps24l5; Rps24l7", "gene_names_refseq": "L33; Rps24", "protein_names_uniprotkb": "Small ribosomal subunit protein eS24; 40S ribosomal protein S24", "protein_names_refseq": "40S ribosomal protein S24; small ribosomal subunit protein eS24", "tax_id": 10116, "disease": "Diamond-blackfan anemia 3 (Disease Ontology:DOID:0111887); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:306259); (rno:315035); (rno:81776); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 15, "publication_count": 2, "publication_id_list": "2335205;38843836", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P16632;Q6PEC9", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0005840 ribosome;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0006413 translational initiation;GO:0097421 liver regeneration;GO:0034101 erythrocyte homeostasis;GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62850-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29598-1", "uniprot_id": "UROK_RAT", "mass": 47957.0, "length": 432, "protein_name": "Urokinase-type plasminogen activator", "gene_name": "Plau", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Plau", "gene_names_refseq": "", "protein_names_uniprotkb": "Urokinase-type plasminogen activator; 3.4.21.73; U-plasminogen activator; uPA", "protein_names_refseq": "", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); autism spectrum disorder (Disease Ontology:DOID:0060041); thrombosis (Disease Ontology:DOID:0060903); Alzheimer's disease 1 (Disease Ontology:DOID:0080348); urolithiasis (Disease Ontology:DOID:0080653); Quebec platelet disorder (Disease Ontology:DOID:0111050); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); autistic disorder (Disease Ontology:DOID:12849); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); hepatitis B (Disease Ontology:DOID:2043); transient cerebral ischemia (Disease Ontology:DOID:224); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); pleural empyema (Disease Ontology:DOID:3798); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); renal cell carcinoma (Disease Ontology:DOID:4450); brain edema (Disease Ontology:DOID:4724); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); peritonitis (Disease Ontology:DOID:8283); appendicitis (Disease Ontology:DOID:8337); steatotic liver disease (Disease Ontology:DOID:9452); meningitis (Disease Ontology:DOID:9471); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (R-RNO-6798695); (R-RNO-75205)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1321734;1568219;29393594", "class_list": "", "function": "Serine protease that cleaves the inactive precursor plasminogen at a specific Arg-Val peptide bond, converting it into active plasmin. Secreted as an inactive zymogen, it is recruited and activated at the cell surface through interaction with the urokinase plasminogen activator receptor (uPAR). Cell-surface activation enables localized, plasmin-dependent pericellular proteolysis, regulating extracellular matrix degradation in cell migration and tissue remodeling (By similarity). Also contributes to fibrinolysis and blood clot clearance by promoting plasmin generation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 38, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LBK5", "ec_number_list": "3.1.3.48;7.6.2.1;3.6.5.2;2.3.1.51;2.7.11.1;1.14.14.18;3.4.21.73;1.1.1.-;3.1.4.4;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.3.2.27;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;1.14.19.17;5.2.1.-;3.2.2.6;3.2.1.20;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:1905370 serine-type endopeptidase complex;GO:0097180 serine protease inhibitor complex;GO:0098637 protein complex involved in cell-matrix adhesion", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0043403 skeletal muscle tissue regeneration;GO:2000345 regulation of hepatocyte proliferation;GO:0035728 response to hepatocyte growth factor;GO:2000097 regulation of smooth muscle cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P29598-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJZ1-1", "uniprot_id": "RTEL1_RAT", "mass": 141779.0, "length": 1274, "protein_name": "Regulator of telomere elongation helicase 1", "gene_name": "Rtel1", "organism": "Rat", "refseq_name": "regulator of telomere elongation helicase 1 isoform 1", "refseq_ac": "NP_001178786", "gene_names_uniprotkb": "Rtel1; RTEL1", "gene_names_refseq": "RGD1306721; Rtel1", "protein_names_uniprotkb": "Regulator of telomere elongation helicase 1; 5.6.2.-", "protein_names_refseq": "helicase-like protein NHL; regulator of telomere elongation helicase 1 isoform 1", "tax_id": 10116, "disease": "female breast cancer (Disease Ontology:DOID:0050671); autosomal recessive dyskeratosis congenita 5 (Disease Ontology:DOID:0070022); prostate cancer (Disease Ontology:DOID:10283); silicosis (Disease Ontology:DOID:10325); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); childhood astrocytic tumor (Disease Ontology:DOID:3079); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gastric adenocarcinoma (Disease Ontology:DOID:3717); mixed glioma (Disease Ontology:DOID:5076)", "pathway": " (rno:362288); (R-RNO-171319); (R-RNO-174430)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;5.4.99.-;2.7.4.3;2.7.11.22;3.1.4.-;3.1.3.16;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0031965 nuclear membrane;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0043247 telomere maintenance in response to DNA damage;GO:0090657 telomeric loop disassembly;GO:1904430 negative regulation of t-circle formation;GO:1904506 negative regulation of telomere maintenance in response to DNA damage;GO:1904535 positive regulation of telomeric loop disassembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83900-1", "uniprot_id": "RPGF5_RAT", "mass": 67601.0, "length": 580, "protein_name": "Rap guanine nucleotide exchange factor 5", "gene_name": "Rapgef5", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rapgef5; Mrgef", "gene_names_refseq": "", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 5; M-Ras-regulated Rap GEF; MR-GEF; rMR-GEF", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:362799)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14643017", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0007265 Ras protein signal transduction;GO:0014911 positive regulation of smooth muscle cell migration;GO:0061548 ganglion development;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83900-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49432-1", "uniprot_id": "ODPB_RAT", "mass": 38982.0, "length": 359, "protein_name": "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial", "gene_name": "Pdhb", "organism": "Rat", "refseq_name": "pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor", "refseq_ac": "NP_001007621", "gene_names_uniprotkb": "Pdhb", "gene_names_refseq": "Pdhb", "protein_names_uniprotkb": "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; 1.2.4.1; PDHE1-B", "protein_names_refseq": "PDHE1-B; pyruvate dehydrogenase (lipoamide) beta; pyruvate dehydrogenase E1 beta subunit; pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor; pyruvate dehydrogenase E1 component subunit beta, mitochondrial", "tax_id": 10116, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649)", "pathway": " (rno:289950); (R-RNO-204174); (R-RNO-5362517); (R-RNO-9837999); (R-RNO-9861559)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "18683930;2025639;22569713;25451023;26446791;27213235;28100784;34502162", "class_list": "", "function": "Phosphorylation of the pyruvate dehydrogenase E1-beta leads to a decrease in ventricular ATP level during myocardial infarction., [RefSeq, PubMed]; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Together with PDHA1 forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Up-regulated by 23 % in peritoneal adhesions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6AY95", "ec_number_list": "2.3.1.-;6.1.1.5;1.3.8.5;6.2.1.4;4.98.1.1;5.6.2.3;1.2.4.1;2.8.3.5;2.3.1.41;3.4.21.92;3.5.3.1;2.7.11.2;2.7.11.-;3.1.2.2;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.2.-;3.1.3.43;1.1.1.37;6.4.1.3;2.3.1.12;7.1.2.2;1.4.1.3;1.2.1.3;2.3.1.37;4.2.1.2;2.3.1.9;2.3.3.10;5.3.3.8;1.1.1.30;3.6.4.10;1.1.1.42;5.6.1.7;1.3.8.1;2.7.1.23;1.2.4.2;5.3.3.21;7.1.1.2;1.2.1.36;1.7.1.-;1.2.1.28;1.8.1.4;2.3.3.1;3.4.21.53;1.1.1.41;4.2.1.3", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P49432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62083-1", "uniprot_id": "RS7_RAT", "mass": 22127.0, "length": 194, "protein_name": "Small ribosomal subunit protein eS7", "gene_name": "Colec11; Rps7", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS7", "refseq_ac": "NP_113758", "gene_names_uniprotkb": "Colec11; Rps7; Colec11; Rps7-ps23; Rps7", "gene_names_refseq": "Rps7", "protein_names_uniprotkb": "Small ribosomal subunit protein eS7; 40S ribosomal protein S7; S8", "protein_names_refseq": "40S ribosomal protein S7; S8; small ribosomal subunit protein eS7", "tax_id": 10116, "disease": "3MC syndrome 2 (Disease Ontology:DOID:0060576); Diamond-Blackfan anemia 8 (Disease Ontology:DOID:0111881)", "pathway": " (rno:29258); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 3, "publication_id_list": "2030949;2226813;38843836", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for rRNA maturation. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P23821;P24818", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0003730 mRNA 3'-UTR binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0048027 mRNA 5'-UTR binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0030154 cell differentiation;GO:0001843 neural tube closure;GO:0006412 translation;GO:0006364 rRNA processing;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62083-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M887-1", "uniprot_id": "TPC13_RAT", "mass": 46520.0, "length": 418, "protein_name": "Trafficking protein particle complex subunit 13", "gene_name": "Trappc13", "organism": "Rat", "refseq_name": "trafficking protein particle complex subunit 13", "refseq_ac": "NP_001013930", "gene_names_uniprotkb": "Trappc13", "gene_names_refseq": "RGD1306583; Trappc13", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 13", "protein_names_refseq": "UPF0533 protein C5orf44 homolog; trafficking protein particle complex 13; trafficking protein particle complex subunit 13", "tax_id": 10116, "disease": "", "pathway": " (rno:294709); (R-RNO-8876198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the multisubunit TRAPP (transport protein particle) III complex (By similarity). As a component of TRAPPIII complex, participates in the activation of RAB1 and RAB43, but not RAB11A, RAB11B, nor RAB19 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:1990072 TRAPPIII protein complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M887-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5EBA3-1", "uniprot_id": "SPIB_RAT", "mass": 29400.0, "length": 269, "protein_name": "Transcription factor Spi-B", "gene_name": "Spib", "organism": "Rat", "refseq_name": "transcription factor Spi-B", "refseq_ac": "NP_001019457", "gene_names_uniprotkb": "Spib", "gene_names_refseq": "Spib", "protein_names_uniprotkb": "Transcription factor Spi-B", "protein_names_refseq": "Spi-B transcription factor (Spi-1/PU.1 related); transcription factor Spi-B", "tax_id": 10116, "disease": "", "pathway": " (rno:499146)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0002327 immature B cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EBA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3MHU3-1", "uniprot_id": "TDRD9_RAT", "mass": 156156.0, "length": 1384, "protein_name": "ATP-dependent RNA helicase TDRD9", "gene_name": "Tdrd9", "organism": "Rat", "refseq_name": "ATP-dependent RNA helicase TDRD9", "refseq_ac": "NP_001406506", "gene_names_uniprotkb": "Tdrd9", "gene_names_refseq": "Tdrd9", "protein_names_uniprotkb": "ATP-dependent RNA helicase TDRD9; 3.6.4.13; Tudor domain-containing protein 9", "protein_names_refseq": "ATP-dependent RNA helicase TDRD9; putative ATP-dependent RNA helicase TDRD9; tudor domain-containing protein 9", "tax_id": 10116, "disease": "spermatogenic failure 30 (Disease Ontology:DOID:0111913)", "pathway": " (rno:299343)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.1.4.-;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071547 piP-body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0030154 cell differentiation;GO:0007140 male meiotic nuclear division;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PPJ2-1", "uniprot_id": "RSRC1_RAT", "mass": 38668.0, "length": 334, "protein_name": "Serine/Arginine-related protein 53", "gene_name": "Rsrc1", "organism": "Rat", "refseq_name": "serine/Arginine-related protein 53", "refseq_ac": "NP_001014194", "gene_names_uniprotkb": "Rsrc1; Srrp53", "gene_names_refseq": "RGD1304968; Rsrc1; SRrp53", "protein_names_uniprotkb": "Serine/Arginine-related protein 53; Arginine/serine-rich coiled-coil protein 1; SRrp53", "protein_names_refseq": "arginine/serine-rich coiled-coil 1; arginine/serine-rich coiled-coil protein 1; serine/Arginine-related protein 53", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 70 (Disease Ontology:DOID:0081231)", "pathway": " (rno:361956)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006913 nucleocytoplasmic transport;GO:0008380 RNA splicing;GO:0046677 response to antibiotic;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PPJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q568Y5-1", "uniprot_id": "TSN11_RAT", "mass": 28017.0, "length": 253, "protein_name": "Tetraspanin-11", "gene_name": "Tspan11", "organism": "Rat", "refseq_name": "tetraspanin-11", "refseq_ac": "NP_001019433", "gene_names_uniprotkb": "Tspan11", "gene_names_refseq": "RGD1305424; Tspan11", "protein_names_uniprotkb": "Tetraspanin-11; Tspan-11", "protein_names_refseq": "tetraspanin-11; tspan-11", "tax_id": 10116, "disease": "", "pathway": " (rno:312727)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Facilitates focal adhesion assembly to regulate osteoblast alignment and guide bone matrix formation orthogonally to cell orientation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0048041 focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q568Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4G069-1", "uniprot_id": "RMD1_RAT", "mass": 35401.0, "length": 310, "protein_name": "Regulator of microtubule dynamics protein 1", "gene_name": "Rmdn1", "organism": "Rat", "refseq_name": "regulator of microtubule dynamics protein 1", "refseq_ac": "NP_001026833", "gene_names_uniprotkb": "Rmdn1; Fam82b", "gene_names_refseq": "Fam82b; Rmdn1", "protein_names_uniprotkb": "Regulator of microtubule dynamics protein 1; Protein FAM82B; RMD-1", "protein_names_refseq": "RMD-1; family with sequence similarity 82, member B; regulator of microtubule dynamics protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:500419)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005876 spindle microtubule;GO:0097431 mitotic spindle pole", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4G069-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q569A2-1", "uniprot_id": "TSN12_RAT", "mass": 35378.0, "length": 305, "protein_name": "Tetraspanin-12", "gene_name": "Tspan12", "organism": "Rat", "refseq_name": "tetraspanin-12", "refseq_ac": "NP_001015026", "gene_names_uniprotkb": "Tspan12; Tm4sf12", "gene_names_refseq": "Tm4sf12; Tspan12", "protein_names_uniprotkb": "Tetraspanin-12; Transmembrane 4 superfamily member 12; Tspan-12", "protein_names_refseq": "tetraspanin-12; transmembrane 4 superfamily member 12; tspan-12", "tax_id": 10116, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); exudative vitreoretinopathy 5 (Disease Ontology:DOID:0111408)", "pathway": " (rno:362326)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0010842 retina layer formation;GO:0045765 regulation of angiogenesis;GO:0035633 maintenance of blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q569A2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60123-1", "uniprot_id": "RUVB1_RAT", "mass": 50214.0, "length": 456, "protein_name": "RuvB-like 1", "gene_name": "Ruvbl1", "organism": "Rat", "refseq_name": "ruvB-like 1", "refseq_ac": "NP_671706", "gene_names_uniprotkb": "Ruvbl1; Tip49a; Tip49", "gene_names_refseq": "NMP238; Pontin52; Ruvbl1; Tip49a", "protein_names_uniprotkb": "RuvB-like 1; 3.6.4.12; 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; DNA helicase p50; Pontin 52; TIP49a", "protein_names_refseq": "49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; DNA helicase p50; RuvB-like protein 1; pontin 52; ruvB-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:65137); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-5696394); (R-RNO-606279)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10050036;10336418;9196036", "class_list": "", "function": "Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (By similarity). Essential for cell proliferation (By similarity). May be able to bind plasminogen at cell surface and enhance plasminogen activation (By similarity)., [UniProtKB, UniProtKB]; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35753", "ec_number_list": "5.6.2.3;3.6.4.13;2.3.2.32;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;3.4.19.12;5.6.2.4;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;1.14.11.-;2.7.4.3;3.1.4.-;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0051117 ATPase binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0010756 positive regulation of plasminogen activation;GO:2000269 regulation of fibroblast apoptotic process;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P60123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2IBD0-1", "uniprot_id": "ST7_RAT", "mass": 66111.0, "length": 577, "protein_name": "Suppressor of tumorigenicity 7 protein", "gene_name": "St7", "organism": "Rat", "refseq_name": "suppressor of tumorigenicity 7 protein isoform X1", "refseq_ac": "XP_006236194", "gene_names_uniprotkb": "St7; ST7", "gene_names_refseq": "ST7", "protein_names_uniprotkb": "Suppressor of tumorigenicity 7 protein", "protein_names_refseq": "suppressor of tumorigenicity 7 protein isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "12917688", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q499P1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2IBD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499U8-1", "uniprot_id": "TMCO4_RAT", "mass": 67795.0, "length": 631, "protein_name": "Transmembrane and coiled-coil domain-containing protein 4", "gene_name": "Tmco4", "organism": "Rat", "refseq_name": "transmembrane and coiled-coil domain-containing protein 4", "refseq_ac": "NP_001030121", "gene_names_uniprotkb": "Tmco4", "gene_names_refseq": "Tmco4", "protein_names_uniprotkb": "Transmembrane and coiled-coil domain-containing protein 4", "protein_names_refseq": "rCG31182-like; transmembrane and coiled-coil domain-containing protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:500573)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499U8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q496Z4-1", "uniprot_id": "TMC4_RAT", "mass": 78211.0, "length": 698, "protein_name": "Voltage-gated chloride channel TMC4", "gene_name": "Tmc4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tmc4", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-gated chloride channel TMC4; Transmembrane channel-like protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:308310)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Voltage-gated chloride channel involved in high-concentration salt taste sensation. Depolarization induced by high NaCl concentration may trigger the activation of TMC4-mediated chloride influx into taste bud cells, helping the return to resting potential. Also allows permeation of organic anions including gluconate, but their current amplitudes at positive potentials are less than that of chloride. Involved in pH and temperature-dependent modulation of salty taste., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;1.11.1.-;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0005247 voltage-gated chloride channel activity;GO:0008381 mechanosensitive monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050914 sensory perception of salty taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q496Z4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50753-1", "uniprot_id": "TNNT2_RAT", "mass": 35730.0, "length": 299, "protein_name": "Troponin T, cardiac muscle", "gene_name": "Tnnt2", "organism": "Rat", "refseq_name": "troponin T, cardiac muscle isoform 1", "refseq_ac": "NP_036808", "gene_names_uniprotkb": "Tnnt2", "gene_names_refseq": "CTTG; Ctt; RATCTTG; Tnnt2; Tnnt3", "protein_names_uniprotkb": "Troponin T, cardiac muscle; Cardiac muscle troponin T; TnTc; cTnT", "protein_names_refseq": "Troponin T cardiac; cTnT; cardiac muscle troponin T; cardiac troponin T2; tnTc; troponin T type 2 (cardiac); troponin T, cardiac muscle isoform 1; troponin T, cardiac muscle", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); COVID-19 (Disease Ontology:DOID:0080600); hypertrophic cardiomyopathy 2 (Disease Ontology:DOID:0110308); dilated cardiomyopathy 1D (Disease Ontology:DOID:0110426); familial restrictive cardiomyopathy 3 (Disease Ontology:DOID:0111427); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); nemaline myopathy (Disease Ontology:DOID:3191); restrictive cardiomyopathy (Disease Ontology:DOID:397); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:24837); (R-RNO-390522)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1433301;19381846;22673903;25916824;2760070;32322013;32429250;34502162", "class_list": "", "function": "Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers. Publication Status: Online-Only, [RefSeq, PubMed]; The Liver and Kidneys mediate clearance of cardiac troponin in the rat. Publication Status: Online-Only, [RefSeq, PubMed]; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030172 troponin C binding;GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:1990584 cardiac Troponin complex;GO:0005737 cytoplasm;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere;GO:0030016 myofibril", "go_biological_process": "GO:0006936 muscle contraction;GO:0007507 heart development;GO:0051592 response to calcium ion;GO:0009617 response to bacterium;GO:0008016 regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P50753-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3SWU0-1", "uniprot_id": "TRBP2_RAT", "mass": 38850.0, "length": 365, "protein_name": "RISC-loading complex subunit TARBP2", "gene_name": "Tarbp2", "organism": "Rat", "refseq_name": "RISC-loading complex subunit TARBP2", "refseq_ac": "NP_001030113", "gene_names_uniprotkb": "Tarbp2; TARBP2", "gene_names_refseq": "Tarbp2", "protein_names_uniprotkb": "RISC-loading complex subunit TARBP2", "protein_names_refseq": "RISC-loading complex subunit TARBP2; TAR (HIV) RNA binding protein 2; TAR (HIV-1) RNA binding protein 2; TARBP2, RISC loading complex RNA binding subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:363006); (R-RNO-203927); (R-RNO-426486); (R-RNO-9833482)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0003725 double-stranded RNA binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0016442 RISC complex", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0050689 negative regulation of defense response to virus by host;GO:0070922 RISC complex assembly;GO:0007286 spermatid development;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3MIF4-1", "uniprot_id": "XYLB_RAT", "mass": 57970.0, "length": 536, "protein_name": "Xylulose kinase", "gene_name": "Xylb", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Xylb", "gene_names_refseq": "", "protein_names_uniprotkb": "Xylulose kinase; 2.7.1.17; Xylulokinase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:316067); (R-RNO-5661270)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.17", "go_molecular_function": "GO:0005524 ATP binding;GO:0004856 D-xylulokinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0005997 xylulose metabolic process;GO:0042732 D-xylose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MIF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8E0-1", "uniprot_id": "TSN17_RAT", "mass": 30110.0, "length": 270, "protein_name": "Tetraspanin-17", "gene_name": "Tspan17", "organism": "Rat", "refseq_name": "tetraspanin-17", "refseq_ac": "NP_001013156", "gene_names_uniprotkb": "Tspan17; Fbxo23", "gene_names_refseq": "Fbxo23; GHB-R; Tspan17", "protein_names_uniprotkb": "Tetraspanin-17; F-box only protein 23; Tspan-17", "protein_names_refseq": "F-box only protein 23; gamma-hydroxybutyrate receptor; tetraspanin-17; tspan-17", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:306771)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16874802;18991884", "class_list": "", "function": "Immunohistochemical analyses showed receptor protein distribution closely resembling the distribution of GHB high-affinity binding sites, except for cerebellum. The GHB receptor-like protein labeling appears to be distributed specifically in neurons., [RefSeq, PubMed]; Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (By similarity). Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results indicate that ethanol does not affect [(3)H]NCS-382 binding in the rat brain, thereby suggesting that ethanol does not interact directly with the GHB receptor., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0051604 protein maturation;GO:0051043 regulation of membrane protein ectodomain proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V8E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2T3-1", "uniprot_id": "SPS2L_RAT", "mass": 61774.0, "length": 558, "protein_name": "SPATS2-like protein", "gene_name": "Spats2l", "organism": "Rat", "refseq_name": "SPATS2-like protein isoform 4", "refseq_ac": "NP_001014124", "gene_names_uniprotkb": "Spats2l", "gene_names_refseq": "RGD1309930; Spats2l", "protein_names_uniprotkb": "SPATS2-like protein", "protein_names_refseq": "SPATS2-like protein isoform 4; SPATS2-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:316426)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2T3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70567-1", "uniprot_id": "TMOD1_RAT", "mass": 40480.0, "length": 359, "protein_name": "Tropomodulin-1", "gene_name": "Tmod1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tmod1; Tmod", "gene_names_refseq": "", "protein_names_uniprotkb": "Tropomodulin-1; E-Tmod; Erythrocyte tropomodulin", "protein_names_refseq": "", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (R-RNO-390522)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "37126682;8886980", "class_list": "", "function": "Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0016020 membrane;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0008344 adult locomotory behavior;GO:0051694 pointed-end actin filament capping;GO:0070307 lens fiber cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70567-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVN2-1", "uniprot_id": "TM41B_RAT", "mass": 32511.0, "length": 291, "protein_name": "Transmembrane protein 41B", "gene_name": "Tmem41b", "organism": "Rat", "refseq_name": "transmembrane protein 41B", "refseq_ac": "NP_001012358", "gene_names_uniprotkb": "Tmem41b", "gene_names_refseq": "RGD1310870; Tmem41b", "protein_names_uniprotkb": "Transmembrane protein 41B", "protein_names_refseq": "protein stasimon; transmembrane protein 41B", "tax_id": 10116, "disease": "", "pathway": " (rno:361626)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Required for normal motor neuron development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.-.-;1.6.5.5", "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0016020 membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0007399 nervous system development;GO:0044830 host-mediated perturbation of viral RNA genome replication;GO:0032365 intracellular lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PQR6-1", "uniprot_id": "SMA2L_RAT", "mass": 51238.0, "length": 454, "protein_name": "Sperm microtubule associated protein 2-like", "gene_name": "Spmap2l", "organism": "Rat", "refseq_name": "sperm microtubule associated protein 2-like", "refseq_ac": "NP_001017498", "gene_names_uniprotkb": "Spmap2l; Thegl", "gene_names_refseq": "Spmap2l; Thegl", "protein_names_uniprotkb": "Sperm microtubule associated protein 2-like; Testicular haploid expressed gene protein-like; Theg spermatid-like protein", "protein_names_refseq": "sperm microtubule associated protein 2-like; testicular haploid expressed gene protein-like; theg spermatid protein-like; theg spermatid-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:498350)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q566R0-1", "uniprot_id": "THEM4_RAT", "mass": 26089.0, "length": 230, "protein_name": "Acyl-coenzyme A thioesterase THEM4", "gene_name": "Them4", "organism": "Rat", "refseq_name": "acyl-coenzyme A thioesterase THEM4", "refseq_ac": "NP_001020188", "gene_names_uniprotkb": "Them4", "gene_names_refseq": "RGD1304723; Them4", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase THEM4; 3.1.2.2; Acyl-CoA thioesterase THEM4; Thioesterase superfamily member 4", "protein_names_refseq": "acyl-CoA thioesterase THEM4; acyl-coenzyme A thioesterase THEM4", "tax_id": 10116, "disease": "", "pathway": " (rno:361992); (R-RNO-1257604); (R-RNO-165158); (R-RNO-199418); (R-RNO-389357); (R-RNO-5218920); (R-RNO-77289)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "19349976", "class_list": "", "function": "CTMP is important in the neurodegeneration that is associated with stroke and identify CTMP as a therapeutic target for the amelioration of hippocampal injury and cognitive deficits., [RefSeq, PubMed]; Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.2;3.5.2.6;3.1.2.-;3.1.2.14;3.1.2.1;2.3.1.16;2.3.1.9;2.7.10.2;2.7.11.1;3.1.2.22;3.1.1.4;3.1.1.5;3.1.2.27;2.3.1.65;3.1.2.11;3.1.2.3;3.1.2.5", "go_molecular_function": "GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0032587 ruffle membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q566R0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q494T4-1", "uniprot_id": "TMM54_RAT", "mass": 23328.0, "length": 216, "protein_name": "Transmembrane protein 54", "gene_name": "Tmem54", "organism": "Rat", "refseq_name": "transmembrane protein 54", "refseq_ac": "NP_001029323", "gene_names_uniprotkb": "Tmem54", "gene_names_refseq": "RGD1304886; Tmem54", "protein_names_uniprotkb": "Transmembrane protein 54", "protein_names_refseq": "beta-casein-like protein; transmembrane protein 54", "tax_id": 10116, "disease": "", "pathway": " (rno:362605)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q494T4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U1Y0-1", "uniprot_id": "TM192_RAT", "mass": 30252.0, "length": 266, "protein_name": "Transmembrane protein 192", "gene_name": "Tmem192", "organism": "Rat", "refseq_name": "transmembrane protein 192", "refseq_ac": "NP_001014163", "gene_names_uniprotkb": "Tmem192", "gene_names_refseq": "RGD1309341; Tmem192", "protein_names_uniprotkb": "Transmembrane protein 192", "protein_names_refseq": "transmembrane protein 192", "tax_id": 10116, "disease": "", "pathway": " (rno:361137)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005768 endosome;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0005770 late endosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U1Y0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2N0-1", "uniprot_id": "PYRG2_RAT", "mass": 65674.0, "length": 586, "protein_name": "CTP synthase 2", "gene_name": "Ctps2", "organism": "Rat", "refseq_name": "CTP synthase 2", "refseq_ac": "NP_001030170", "gene_names_uniprotkb": "Ctps2", "gene_names_refseq": "Ctps2", "protein_names_uniprotkb": "CTP synthase 2; 6.3.4.2; CTP synthetase 2; UTP--ammonia ligase 2", "protein_names_refseq": "CTP synthase 2; CTP synthase II; CTP synthetase 2; UTP--ammonia ligase 2; cytidine 5'-triphosphate synthase 2; cytidine triphosphate synthase II", "tax_id": 10116, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:619580); (R-RNO-499943)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U3X4", "ec_number_list": "6.3.4.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003883 CTP synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097268 cytoophidium", "go_biological_process": "GO:0044210 'de novo' CTP biosynthetic process;GO:0006241 CTP biosynthetic process;GO:0019856 pyrimidine nucleobase biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2N0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2T7-1", "uniprot_id": "TFB2M_RAT", "mass": 46021.0, "length": 397, "protein_name": "Dimethyladenosine transferase 2, mitochondrial", "gene_name": "Tfb2m", "organism": "Rat", "refseq_name": "dimethyladenosine transferase 2, mitochondrial", "refseq_ac": "NP_001008294", "gene_names_uniprotkb": "Tfb2m", "gene_names_refseq": "Tfb2m", "protein_names_uniprotkb": "Dimethyladenosine transferase 2, mitochondrial; 2.1.1.-; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; mtTFB2", "protein_names_refseq": "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; dimethyladenosine transferase 2, mitochondrial-like; dimethyladenosine transferase 2, mitochondrial; mitochondrial 12S rRNA dimethylase 2; mitochondrial transcription factor B2; mtTFB2", "tax_id": 10116, "disease": "", "pathway": " (rno:289307); (R-RNO-163282)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21113058", "class_list": "", "function": "Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription in cardiac myocytes., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.6;2.1.1.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0034246 mitochondrial transcription factor activity;GO:0008988 rRNA (adenine-N6-)-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0031167 rRNA methylation;GO:0006391 transcription initiation at mitochondrial promoter;GO:0006390 mitochondrial transcription;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U300-1", "uniprot_id": "UBA1_RAT", "mass": 117788.0, "length": 1058, "protein_name": "Ubiquitin-like modifier-activating enzyme 1", "gene_name": "Uba1", "organism": "Rat", "refseq_name": "ubiquitin-like modifier-activating enzyme 1", "refseq_ac": "NP_001014102", "gene_names_uniprotkb": "Uba1; Ube1", "gene_names_refseq": "Uba1; Ube1x", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme 1; 6.2.1.45; Ubiquitin-activating enzyme E1", "protein_names_refseq": "ubiquitin-activating enzyme E1, Chr X; ubiquitin-like modifier-activating enzyme 1", "tax_id": 10116, "disease": "VEXAS syndrome (Disease Ontology:DOID:0080828); X-linked spinal muscular atrophy 2 (Disease Ontology:DOID:0111827)", "pathway": " (rno:314432); (R-RNO-8866652); (R-RNO-983168)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "18818210;22673903;26919560;34502162", "class_list": "", "function": "Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; E1 ligase of the proteasome is inhibitd by ziram and has a role in preventing dopaminergic cell damage, [RefSeq, PubMed]; UBA1 inhibition effectively suppresses neointimal thickening through its anti-proliferative and anti-inflammatory effects in carotid artery injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.23;2.3.2.34;2.3.2.24;2.3.2.25;6.2.1.45;6.2.1.64", "go_molecular_function": "GO:0005524 ATP binding;GO:0004839 ubiquitin activating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5U300-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BK85-1", "uniprot_id": "TMED1_RAT", "mass": 25210.0, "length": 227, "protein_name": "Transmembrane emp24 domain-containing protein 1", "gene_name": "Tmed1", "organism": "Rat", "refseq_name": "transmembrane emp24 domain-containing protein 1 precursor", "refseq_ac": "NP_001013450", "gene_names_uniprotkb": "Tmed1; Il1rl1l", "gene_names_refseq": "Il1rl1l; Tmed1", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 1; Interleukin-1 receptor-like 1 ligand; p24 family protein gamma-1; p24gamma1", "protein_names_refseq": "interleukin-1 receptor-like 1 ligand; p24 family protein gamma-1; p24gamma1; transmembrane emp24 domain containing 1; transmembrane emp24 domain-containing protein 1 precursor; transmembrane emp24 domain-containing protein 1; transmembrane emp24 protein transport domain containing 1", "tax_id": 10116, "disease": "", "pathway": " (rno:315461)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1. Plays also a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PQN9-1", "uniprot_id": "RM38_RAT", "mass": 44838.0, "length": 380, "protein_name": "Large ribosomal subunit protein mL38", "gene_name": "Mrpl38", "organism": "Rat", "refseq_name": "large ribosomal subunit protein mL38", "refseq_ac": "NP_001009369", "gene_names_uniprotkb": "Mrpl38", "gene_names_refseq": "Mrpl38", "protein_names_uniprotkb": "Large ribosomal subunit protein mL38; 39S ribosomal protein L38, mitochondrial; L38mt; MRP-L38", "protein_names_refseq": "39S ribosomal protein L38, mitochondrial; L38mt; MRP-L38; large ribosomal subunit protein mL38", "tax_id": 10116, "disease": "", "pathway": " (rno:303685); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XFW2-1", "uniprot_id": "TRUB2_RAT", "mass": 36109.0, "length": 323, "protein_name": "Pseudouridylate synthase TRUB2, mitochondrial", "gene_name": "Trub2", "organism": "Rat", "refseq_name": "pseudouridylate synthase TRUB2, mitochondrial", "refseq_ac": "NP_001014279", "gene_names_uniprotkb": "Trub2", "gene_names_refseq": "Trub2", "protein_names_uniprotkb": "Pseudouridylate synthase TRUB2, mitochondrial; 5.4.99.-; 5.4.99.25; Psi55 synthase TRUB2; TruB pseudouridine synthase homolog 2; tRNA pseudouridine 55 synthase TRUB2", "protein_names_refseq": "TruB pseudouridine (psi) synthase family member 2; mitochondrial mRNA pseudouridine synthase Trub2; probable tRNA pseudouridine synthase 2; pseudouridylate synthase TRUB2, mitochondrial; psi55 synthase TRUB2; tRNA pseudouridine 55 synthase TRUB2; truB pseudouridine synthase homolog 2", "tax_id": 10116, "disease": "", "pathway": " (rno:366012)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.4.99.25;5.4.99.-;5.4.99.12", "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity;GO:0160148 tRNA pseudouridine(55) synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0006397 mRNA processing;GO:1990481 mRNA pseudouridine synthesis;GO:0070131 positive regulation of mitochondrial translation;GO:0070902 mitochondrial tRNA pseudouridine synthesis;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XFW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499N6-1", "uniprot_id": "UBXN1_RAT", "mass": 33582.0, "length": 297, "protein_name": "UBX domain-containing protein 1", "gene_name": "Ubxn1", "organism": "Rat", "refseq_name": "UBX domain-containing protein 1", "refseq_ac": "NP_001030001", "gene_names_uniprotkb": "Ubxn1; Lrrn4cl; Saks1", "gene_names_refseq": "2B28; RGD1309471; Ubxn1", "protein_names_uniprotkb": "UBX domain-containing protein 1; SAPK substrate protein 1", "protein_names_refseq": "SAPK substrate protein 1; UBX domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:293719); (R-RNO-532668); (R-RNO-5693565)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15944415", "class_list": "", "function": "Specific interaction of rat protein 2B28 with rat Homer2 may play a role in regulation of protein degradation by ubiquitin-proteasome systems and that this function may be specific to Homer2 proteins among Homer family proteins., [RefSeq, PubMed]; Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0071796 K6-linked polyubiquitin modification-dependent protein binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0031397 negative regulation of protein ubiquitination;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1904293 negative regulation of ERAD pathway;GO:1903094 negative regulation of protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62243-1", "uniprot_id": "RS8_RAT", "mass": 24205.0, "length": 208, "protein_name": "Small ribosomal subunit protein eS8", "gene_name": "Rps8-ps17; Rps8l1; Rps8", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS8", "refseq_ac": "NP_113894", "gene_names_uniprotkb": "Rps8-ps17; Rps8l1; Rps8; RGD1566369; Rps8-ps17; Rps8l1; Rps8l3", "gene_names_refseq": "Rps8", "protein_names_uniprotkb": "Small ribosomal subunit protein eS8; 40S ribosomal protein S8", "protein_names_refseq": "40S ribosomal protein S8; small ribosomal subunit protein eS8", "tax_id": 10116, "disease": "", "pathway": " (rno:100363452); (rno:291353); (rno:65136); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 15, "publication_count": 3, "publication_id_list": "18683930;3684599;398910", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09058", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0098794 postsynapse;GO:0005840 ribosome", "go_biological_process": "GO:0006412 translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62243-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49816-1", "uniprot_id": "TSC2_RAT", "mass": 201278.0, "length": 1809, "protein_name": "Tuberin", "gene_name": "Tsc2", "organism": "Rat", "refseq_name": "tuberin isoform X1", "refseq_ac": "XP_006245971", "gene_names_uniprotkb": "Tsc2", "gene_names_refseq": "Rc; Tsc2", "protein_names_uniprotkb": "Tuberin; Tuberous sclerosis 2 protein homolog", "protein_names_refseq": "tuberin isoform X1", "tax_id": 10116, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); autism spectrum disorder (Disease Ontology:DOID:0060041); tuberous sclerosis 2 (Disease Ontology:DOID:0080325); Alzheimer's disease (Disease Ontology:DOID:10652); leiomyoma (Disease Ontology:DOID:127); uterine fibroid (Disease Ontology:DOID:13223); tuberous sclerosis (Disease Ontology:DOID:13515); breast cancer (Disease Ontology:DOID:1612); anxiety disorder (Disease Ontology:DOID:2030); angiomyolipoma (Disease Ontology:DOID:3314); hepatic angiomyolipoma (Disease Ontology:DOID:3317); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:24855); (R-RNO-1632852); (R-RNO-165181); (R-RNO-198323); (R-RNO-380972); (R-RNO-5628897); (R-RNO-8854214)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "10029074;12172553;16707451;20682696;22673903;23951412;24961241;26121129;7651821;8519695;9045618", "class_list": "", "function": "Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (By similarity). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (By similarity). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (PubMed:16707451). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (PubMed:9045618)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0033596 TSC1-TSC2 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0048550 negative regulation of pinocytosis;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0098976 excitatory chemical synaptic transmission;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P49816-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJK3-1", "uniprot_id": "TM10B_RAT", "mass": 36430.0, "length": 316, "protein_name": "tRNA methyltransferase 10 homolog B", "gene_name": "Trmt10b", "organism": "Rat", "refseq_name": "tRNA methyltransferase 10 homolog B", "refseq_ac": "NP_001013108", "gene_names_uniprotkb": "Trmt10b; Rg9mtd3", "gene_names_refseq": "Rg9mtd3; Trmt10b", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog B; 2.1.1.221; RNA (guanine-9-)-methyltransferase domain-containing protein 3; tRNA (guanine(9)-N(1))-methyltransferase TRMT10B", "protein_names_refseq": "RNA (guanine-9-) methyltransferase domain containing 3; RNA (guanine-9-)-methyltransferase domain-containing protein 3; tRNA (guanine(9)-N(1))-methyltransferase TRMT10B; tRNA methyltransferase 10 homolog B", "tax_id": 10116, "disease": "", "pathway": " (rno:298081)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.221;2.1.1.-;2.1.1.218", "go_molecular_function": "GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane;GO:0002939 tRNA N1-guanine methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62255-1", "uniprot_id": "UB2G1_RAT", "mass": 19509.0, "length": 170, "protein_name": "Ubiquitin-conjugating enzyme E2 G1", "gene_name": "Ube2g1", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 G1", "refseq_ac": "NP_073181", "gene_names_uniprotkb": "Ube2g1; Ubc7; Ube2g", "gene_names_refseq": "Ubc7; Ube2g1", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 G1; 2.3.2.23; E2 ubiquitin-conjugating enzyme G1; E217K; UBC7; Ubiquitin carrier protein G1; Ubiquitin-protein ligase G1", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme G1; E217K; ubiquitin carrier protein G1; ubiquitin-conjugating enzyme E2 G1; ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans); ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast); ubiquitin-conjugating enzyme UBC7; ubiquitin-protein ligase G1", "tax_id": 10116, "disease": "", "pathway": " (rno:64631); (R-RNO-8866652); (R-RNO-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10329663;12869571", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ubc7 mediates inositol 1,4,5-trisphosphate receptor ubiquitination and is a component of the endoplasmic reticulum-associated degradation pathway, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99462", "ec_number_list": "2.3.2.26;2.3.2.32;2.3.2.31;2.3.2.23;2.3.2.27;2.3.2.34;2.3.2.24;2.3.2.-;2.3.2.25;6.2.1.45;6.2.1.64", "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62255-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499P8-1", "uniprot_id": "RUSF1_RAT", "mass": 50779.0, "length": 466, "protein_name": "RUS family member 1", "gene_name": "Rusf1", "organism": "Rat", "refseq_name": "RUS family member 1", "refseq_ac": "NP_001030594", "gene_names_uniprotkb": "Rusf1; RGD1310127", "gene_names_refseq": "RGD1310127; Rusf1", "protein_names_uniprotkb": "RUS family member 1", "protein_names_refseq": "RUS family member 1; RUS1 family protein C16orf58 homolog; UPF0420 protein C16orf58 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:361654)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7A0-1", "uniprot_id": "SKI8_RAT", "mass": 33747.0, "length": 305, "protein_name": "Superkiller complex protein 8", "gene_name": "Skic8", "organism": "Rat", "refseq_name": "superkiller complex protein 8", "refseq_ac": "NP_001020914", "gene_names_uniprotkb": "Skic8; Wdr61", "gene_names_refseq": "RGD1308228; Ski8; Skic8; Wdr61", "protein_names_uniprotkb": "Superkiller complex protein 8; Ski8; WD repeat-containing protein 61, N-terminally processed; WD repeat-containing protein 61", "protein_names_refseq": "SKI8 subunit of superkiller complex protein; WD repeat domain 61; WD repeat-containing protein 61; superkiller complex protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:363064); (R-RNO-112382); (R-RNO-429958); (R-RNO-674695); (R-RNO-75955); (R-RNO-8866654); (R-RNO-9943411)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0055087 Ski complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay;GO:0016055 Wnt signaling pathway;GO:0006368 transcription elongation by RNA polymerase II;GO:0000956 nuclear-transcribed mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7A0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81155-1", "uniprot_id": "VDAC2_RAT", "mass": 31746.0, "length": 295, "protein_name": "Non-selective voltage-gated ion channel VDAC2", "gene_name": "Vdac2", "organism": "Rat", "refseq_name": "non-selective voltage-gated ion channel VDAC2", "refseq_ac": "NP_112644", "gene_names_uniprotkb": "Vdac2", "gene_names_refseq": "Vdac2", "protein_names_uniprotkb": "Non-selective voltage-gated ion channel VDAC2; B36-VDAC; Outer mitochondrial membrane protein porin 2; VDAC-2", "protein_names_refseq": "B36-VDAC; VDAC-2; non-selective voltage-gated ion channel VDAC2; outer mitochondrial membrane protein porin 2; voltage-dependent anion-selective channel protein 2", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); temporal lobe epilepsy (Disease Ontology:DOID:3328); myocardial infarction (Disease Ontology:DOID:5844); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:83531); (R-RNO-5205685); (R-RNO-5689880)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10998068;1373732;17478130;18683930;19423663;22673903;22867515;27213235;30624982;34502162", "class_list": "", "function": "Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (By similarity). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (By similarity). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (By similarity). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity). Associates with the translocase of the outer mitochondrial membrane (TOM) complex and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Paclitaxel increased both alpha- and betaII-tubulin-VDAC2 interactions., [RefSeq, PubMed]; The coupling of VDAC2 with RyR2 is essential for Ca2+ transfer from the sarcoplasmic reticulum to mitochondria in the heart., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI32", "ec_number_list": "7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;3.1.-.-;1.6.5.5;1.11.1.-;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0008142 oxysterol binding;GO:0005524 ATP binding;GO:0015485 cholesterol binding;GO:0031210 phosphatidylcholine binding;GO:0005244 voltage-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0045332 phospholipid translocation;GO:0006820 monoatomic anion transport;GO:2001243 negative regulation of intrinsic apoptotic signaling pathway;GO:0097345 mitochondrial outer membrane permeabilization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P81155-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3T1I9-1", "uniprot_id": "RPAP1_RAT", "mass": 154759.0, "length": 1400, "protein_name": "RNA polymerase II-associated protein 1", "gene_name": "Rpap1", "organism": "Rat", "refseq_name": "RNA polymerase II-associated protein 1", "refseq_ac": "NP_001029171", "gene_names_uniprotkb": "Rpap1", "gene_names_refseq": "Rpap1", "protein_names_uniprotkb": "RNA polymerase II-associated protein 1", "protein_names_refseq": "RNA polymerase II-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:311338)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3T1I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVP5-1", "uniprot_id": "WDR89_RAT", "mass": 42749.0, "length": 386, "protein_name": "WD repeat-containing protein 89", "gene_name": "Wdr89", "organism": "Rat", "refseq_name": "WD repeat-containing protein 89", "refseq_ac": "NP_001014100", "gene_names_uniprotkb": "Wdr89", "gene_names_refseq": "RGD1307393; Wdr89", "protein_names_uniprotkb": "WD repeat-containing protein 89", "protein_names_refseq": "WD repeat-containing protein 89", "tax_id": 10116, "disease": "", "pathway": " (rno:314243)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0021591 ventricular system development;GO:0022038 corpus callosum development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XI96-1", "uniprot_id": "RNH2B_RAT", "mass": 34573.0, "length": 307, "protein_name": "Ribonuclease H2 subunit B", "gene_name": "Rnaseh2b", "organism": "Rat", "refseq_name": "ribonuclease H2 subunit B", "refseq_ac": "NP_001007008", "gene_names_uniprotkb": "Rnaseh2b", "gene_names_refseq": "Rnaseh2b", "protein_names_uniprotkb": "Ribonuclease H2 subunit B; RNase H2 subunit B; Ribonuclease HI subunit B", "protein_names_refseq": "RNase H2 subunit B; ribonuclease H2 subunit B; ribonuclease HI subunit B", "tax_id": 10116, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629)", "pathway": " (rno:361056)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0032299 ribonuclease H2 complex;GO:0005634 nucleus", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0009259 ribonucleotide metabolic process;GO:0001701 in utero embryonic development;GO:0010629 negative regulation of gene expression;GO:0010389 regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25886-1", "uniprot_id": "RL29_RAT", "mass": 17326.0, "length": 156, "protein_name": "Large ribosomal subunit protein eL29", "gene_name": "Rpl29", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL29", "refseq_ac": "NP_058846", "gene_names_uniprotkb": "Rpl29; LOC120095889", "gene_names_refseq": "Rpl29", "protein_names_uniprotkb": "Large ribosomal subunit protein eL29; 60S ribosomal protein L29; P23", "protein_names_refseq": "60S ribosomal protein L29; P23; large ribosomal subunit protein eL29", "tax_id": 10116, "disease": "", "pathway": " (rno:29283); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 6, "publication_id_list": "1544448;1735422;20410138;39395807;8484767;9219540", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0035264 multicellular organism growth;GO:0006412 translation;GO:0031589 cell-substrate adhesion;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P25886-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499R4-1", "uniprot_id": "YRDC_RAT", "mass": 29231.0, "length": 280, "protein_name": "Threonylcarbamoyl-AMP synthase", "gene_name": "Yrdc", "organism": "Rat", "refseq_name": "threonylcarbamoyl-AMP synthase precursor", "refseq_ac": "NP_783194", "gene_names_uniprotkb": "Yrdc", "gene_names_refseq": "Isrip; Yrdc", "protein_names_uniprotkb": "Threonylcarbamoyl-AMP synthase; 2.7.7.87", "protein_names_refseq": "BmTCTP receptor; ischemia/reperfusion inducible protein; ischemia/reperfusion-inducible protein homolog; threonylcarbamoyl-AMP synthase precursor; threonylcarbamoyl-AMP synthase; yrdC domain containing; yrdC domain-containing protein, mitochondrial", "tax_id": 10116, "disease": "Galloway-Mowat syndrome (Disease Ontology:DOID:0080694)", "pathway": " (rno:319113); (R-RNO-6787450)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (By similarity). May regulate the activity of some transporters (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0E4", "ec_number_list": "2.7.7.87", "go_molecular_function": "GO:0000049 tRNA binding;GO:0003725 double-stranded RNA binding;GO:0016779 nucleotidyltransferase activity;GO:0061710 L-threonylcarbamoyladenylate synthase", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0051051 negative regulation of transport;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P69526-1", "uniprot_id": "TMPS9_RAT", "mass": 113890.0, "length": 1061, "protein_name": "Transmembrane protease serine 9", "gene_name": "Tmprss9", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tmprss9", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protease serine 9; 3.4.21.-; Polyserase-1; Polyserase-I; Polyserine protease 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:314636)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12886014", "class_list": "", "function": "Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 5, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0031639 plasminogen activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P69526-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KLL4-1", "uniprot_id": "TM9S4_RAT", "mass": 74675.0, "length": 643, "protein_name": "Transmembrane 9 superfamily member 4", "gene_name": "Tm9sf4", "organism": "Rat", "refseq_name": "transmembrane 9 superfamily member 4 precursor", "refseq_ac": "NP_001020820", "gene_names_uniprotkb": "Tm9sf4", "gene_names_refseq": "Tm9sf4", "protein_names_uniprotkb": "Transmembrane 9 superfamily member 4", "protein_names_refseq": "transmembrane 9 superfamily member 4 precursor; transmembrane 9 superfamily protein member 4", "tax_id": 10116, "disease": "", "pathway": " (rno:296279)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:2000010 positive regulation of protein localization to cell surface;GO:0001666 response to hypoxia;GO:0006909 phagocytosis;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVM1-1", "uniprot_id": "TM231_RAT", "mass": 36170.0, "length": 315, "protein_name": "Transmembrane protein 231", "gene_name": "Tmem231", "organism": "Rat", "refseq_name": "transmembrane protein 231", "refseq_ac": "NP_001257960", "gene_names_uniprotkb": "Tmem231", "gene_names_refseq": "RGD1306153; Tmem231", "protein_names_uniprotkb": "Transmembrane protein 231", "protein_names_refseq": "transmembrane protein 231", "tax_id": 10116, "disease": "Meckel syndrome (Disease Ontology:DOID:0050778); Joubert syndrome 20 (Disease Ontology:DOID:0110989); orofaciodigital syndrome (Disease Ontology:DOID:4501)", "pathway": " (rno:361410)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0036038 MKS complex;GO:0060170 ciliary membrane;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0032880 regulation of protein localization;GO:0060271 cilium assembly;GO:0060563 neuroepithelial cell differentiation;GO:0001944 vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28576-1", "uniprot_id": "PDGFA_RAT", "mass": 23307.0, "length": 204, "protein_name": "Platelet-derived growth factor subunit A", "gene_name": "Pdgfa", "organism": "Rat", "refseq_name": "platelet-derived growth factor subunit A isoform 2 precursor", "refseq_ac": "NP_036933", "gene_names_uniprotkb": "Pdgfa; Rpa1", "gene_names_refseq": "PDGF-1; PDGFACP; Pdgfa", "protein_names_uniprotkb": "Platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide", "protein_names_refseq": "PDGF subunit A; Platelet-derived growth factor A chain; platelet derived growth factor, alpha; platelet-derived growth factor alpha polypeptide; platelet-derived growth factor subunit A isoform 2 precursor", "tax_id": 10116, "disease": "oligohydramnios (Disease Ontology:DOID:12215); leiomyoma (Disease Ontology:DOID:127); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); prostate adenocarcinoma (Disease Ontology:DOID:2526); Leydig cell tumor (Disease Ontology:DOID:2696); high grade glioma (Disease Ontology:DOID:3070); pancreatitis (Disease Ontology:DOID:4989); pulmonary hypertension (Disease Ontology:DOID:6432); chronic ulcer of skin (Disease Ontology:DOID:8549)", "pathway": " (rno:25266); (R-RNO-114608); (R-RNO-1257604); (R-RNO-186763); (R-RNO-186797); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "25899145;26032503;26262503;28358926;34265313;8318539;8447423;8469035", "class_list": "", "function": "An Ntv-a transgenic rat colony was established and used to study glial brain tumors driven by two well-characterized oncogenic gene transformations, PDGFA overexpression and p53 depletion. Combined PDGFA and p53 alterations resulted in large, heterogeneous tumors in all affected animals Publication Status: Online-Only, [RefSeq, PubMed]; Combined inhibition of PGDF and VEGF with sunitinib prevents chronic rejection changes in experimental kidney transplantation., [RefSeq, PubMed]; Expression altered in experimental Necrotizing enterocolitis, [RefSeq, PubMed]; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PDGF regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1., [RefSeq, PubMed]; Platelet derived growth factor-A (Pdgf-a) gene transfer modulates scar composition and improves left ventricular function after myocardial infarction., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005902 microvillus;GO:1990265 platelet-derived growth factor complex;GO:1990270 platelet-derived growth factor receptor-ligand complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0048286 lung alveolus development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P28576-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61515-1", "uniprot_id": "RL37A_RAT", "mass": 10275.0, "length": 92, "protein_name": "Large ribosomal subunit protein eL43", "gene_name": "ENSRNOG00000063418; Rpl37a", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL43", "refseq_ac": "NP_001192247", "gene_names_uniprotkb": "ENSRNOG00000063418; Rpl37a; ENSRNOG00000063418; Rpl37a", "gene_names_refseq": "Rpl37a", "protein_names_uniprotkb": "Large ribosomal subunit protein eL43; 60S ribosomal protein L37a", "protein_names_refseq": "60S ribosomal protein L37a; large ribosomal subunit protein eL43; putative 60S ribosomal protein L37a", "tax_id": 10116, "disease": "", "pathway": " (rno:363248)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2546769;398910", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P12751", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61515-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62902-1", "uniprot_id": "RL31_RAT", "mass": 14463.0, "length": 125, "protein_name": "Large ribosomal subunit protein eL31", "gene_name": "Atp1b3; Rpl31l12; Rpl31l15; Rpl31l2; Rpl31", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL31", "refseq_ac": "NP_071951", "gene_names_uniprotkb": "Atp1b3; Rpl31l12; Rpl31l15; Rpl31l2; Rpl31; AABR07067749.1; AABR07070238.1; Atp1b3; LOC100910017; LOC102550734; LOC108351931; LOC120093557; Rpl31-ps11; Rpl31l12; Rpl31l14; Rpl31l15; Rpl31l2; Rpl31l4", "gene_names_refseq": "Rpl31", "protein_names_uniprotkb": "Large ribosomal subunit protein eL31; 60S ribosomal protein L31", "protein_names_refseq": "60S ribosomal protein L31; large ribosomal subunit protein eL31", "tax_id": 10116, "disease": "", "pathway": " (rno:100360252); (rno:100361974); (rno:108351931); (rno:64298); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "3816785", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P12947", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006883 intracellular sodium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62902-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62329-1", "uniprot_id": "TYB4_RAT", "mass": 5053.0, "length": 44, "protein_name": "Thymosin beta-4", "gene_name": "Tmsb4x", "organism": "Rat", "refseq_name": "thymosin beta-4", "refseq_ac": "NP_112398", "gene_names_uniprotkb": "Tmsb4x; Thyb4; Tmsb4", "gene_names_refseq": "Tmsb4x", "protein_names_uniprotkb": "Thymosin beta-4; Seraspenide; T beta 4", "protein_names_refseq": "t beta 4; thymosin beta-4; thymosin, beta 4, X chromosome", "tax_id": 10116, "disease": "", "pathway": " (rno:81814); (R-RNO-114608)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "22673903;2325669;26457369;29956769;31054361;35979771;3670309;3838131;6201851;6954532", "class_list": "", "function": "Data reveal, that Thymosin beta4 (Tbeta4) inhibits microglia activation in vitro., [RefSeq, PubMed]; In conclusion, Thymosin beta4 significantly increased angiogenesis by enhancing the paracrine effects of Endothelial progenitor cells (EPCs), evidenced by the increased expression of VEGF, [RefSeq, PubMed]; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results show that Tbeta4 increased cell viability and decreased apoptosis of H2O2-injured neural stem/progenitor cells. Also, Tbeta4 attenuated oxidative stress injury in H2O2-injured neural stem/ progenitor cells via the TLR4/MyD88 pathway., [RefSeq, PubMed]; Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase., [UniProtKB]; [Effect and mechanism of thymosin beta 4 on spinal cord-derived neural stem /progenitor cell injury induced by oxidative stress]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01253;P01254;Q0P5V6;Q63576", "ec_number_list": "", "go_molecular_function": "GO:0003785 actin monomer binding;GO:0019899 enzyme binding;GO:0140311 protein sequestering activity;GO:0003788 actin monomer sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:2001171 positive regulation of ATP biosynthetic process;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:0007015 actin filament organization;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P62329-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63281-1", "uniprot_id": "UBC9_RAT", "mass": 18007.0, "length": 158, "protein_name": "SUMO-conjugating enzyme UBC9", "gene_name": "Ube2i", "organism": "Rat", "refseq_name": "SUMO-conjugating enzyme UBC9 isoform 1", "refseq_ac": "NP_037182", "gene_names_uniprotkb": "Ube2i; Ubce9", "gene_names_refseq": "Ubc9; UbcE2A; Ube2i", "protein_names_uniprotkb": "SUMO-conjugating enzyme UBC9; 2.3.2.-; RING-type E3 SUMO transferase UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-conjugating enzyme UbcE2A; Ubiquitin-protein ligase I", "protein_names_refseq": "RING-type E3 SUMO transferase UBC9; SUMO-conjugating enzyme UBC9 isoform 1; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9); ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme UbcE2A; ubiquitin-protein ligase I", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (rno:25573); (R-RNO-196791); (R-RNO-3065678); (R-RNO-3108214); (R-RNO-3232118); (R-RNO-3232142); (R-RNO-3899300); (R-RNO-4085377); (R-RNO-4090294); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-4655427); (R-RNO-4755510); (R-RNO-5693565); (R-RNO-5693607); (R-RNO-5696395); (R-RNO-8866904); (R-RNO-9615933); (R-RNO-9793242); (R-RNO-9856649); (R-RNO-9937850)", "pathway_count": 22, "publication_count": 5, "publication_id_list": "14739995;19498170;30772377;38955308;9013644", "class_list": "", "function": "Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451 (By similarity). Can catalyze the formation of poly-SUMO chains (By similarity). Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386' (By similarity). Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (By similarity). Sumoylates SHMT1 at 'Lys-38' or 'Lys-39' leading to RAN-dependent nuclear import of SHMT1 (By similarity). Also sumoylates TYMS and DHFR (By similarity)., [UniProtKB, UniProtKB]; UBC9 regulates Nav1.5 expression levels in a SUMOylation-independent manner., [RefSeq, PubMed]; UBE2I regulates the nuclear translocation of hnRNPA2B1 by contributing to SUMO modification in osteoarthritis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P50550;Q15698;Q86VB3", "ec_number_list": "3.2.2.29;2.3.2.32;2.3.2.26;1.14.11.69;1.14.11.66;5.6.2.2;2.3.2.-;5.6.2.3;2.4.2.-;2.3.1.48;2.7.11.1;3.5.1.98;2.3.2.27;2.7.11.10;3.4.19.-;5.6.2.4;2.1.1.357;3.6.4.13;3.1.2.-;3.5.1.-;3.5.1.124;2.4.2.30;3.4.21.-;1.14.11.-;2.3.1.-;2.3.2.23;3.6.-.-;3.1.-.-;5.6.2.1;1.1.1.-;2.1.1.37", "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0004842 ubiquitin-protein transferase activity;GO:0019789 SUMO transferase activity;GO:0043425 bHLH transcription factor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:1990234 transferase complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007059 chromosome segregation;GO:0016925 protein sumoylation;GO:0030335 positive regulation of cell migration;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63281-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62982-1", "uniprot_id": "RS27A_RAT", "mass": 17951.0, "length": 156, "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "Rps27a", "organism": "Rat", "refseq_name": "ubiquitin-ribosomal protein eS31 fusion protein", "refseq_ac": "NP_001292372", "gene_names_uniprotkb": "Rps27a; Uba80; Ubcep1", "gene_names_refseq": "Rps27a", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eS31 fusion protein; 40S ribosomal protein S27a; Ubiquitin carboxyl extension protein 80", "protein_names_refseq": "ubiquitin carboxyl extension protein 80; ubiquitin-40S ribosomal protein S27a; ubiquitin-ribosomal protein eS31 fusion protein", "tax_id": 10116, "disease": "", "pathway": " (rno:100912032); (R-RNO-110312); (R-RNO-110314); (R-RNO-110320); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1253288); (R-RNO-1295596); (R-RNO-1358803); (R-RNO-168638); (R-RNO-174048); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-179409); (R-RNO-182971); (R-RNO-187577); (R-RNO-195253); (R-RNO-201681); (R-RNO-202424); (R-RNO-205043); (R-RNO-209543); (R-RNO-209560); (R-RNO-2122948); (R-RNO-2173788); (R-RNO-2173791); (R-RNO-2173795); (R-RNO-2173796); (R-RNO-2467813); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559585); (R-RNO-2565942); (R-RNO-2672351); (R-RNO-2871837); (R-RNO-3134975); (R-RNO-349425); (R-RNO-3769402); (R-RNO-382556); (R-RNO-445989); (R-RNO-450302); (R-RNO-450321); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-4641263); (R-RNO-5205685); (R-RNO-532668); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5655862); (R-RNO-5656121); (R-RNO-5656169); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5675221); (R-RNO-5675482); (R-RNO-5676590); (R-RNO-5684264); (R-RNO-5685942); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689877); (R-RNO-5689880); (R-RNO-5689896); (R-RNO-5689901); (R-RNO-5693537); (R-RNO-5693565); (R-RNO-5696394); (R-RNO-5696395); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6783310); (R-RNO-6804756); (R-RNO-6804757); (R-RNO-6804760); (R-RNO-6807004); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69231); (R-RNO-69481); (R-RNO-69541); (R-RNO-69601); (R-RNO-75815); (R-RNO-8849469); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8863795); (R-RNO-8866427); (R-RNO-8866652); (R-RNO-8866654); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948747); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-901032); (R-RNO-9013507); (R-RNO-9020702); (R-RNO-9033241); (R-RNO-909733); (R-RNO-912631); (R-RNO-917729); (R-RNO-917937); (R-RNO-936440); (R-RNO-936964); (R-RNO-937039); (R-RNO-937041); (R-RNO-937042); (R-RNO-937072); (R-RNO-9645460); (R-RNO-9646399); (R-RNO-9648002); (R-RNO-9664873); (R-RNO-9705462); (R-RNO-975144); (R-RNO-975163); (R-RNO-9755511); (R-RNO-9758274); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-9770562); (R-RNO-9824878); (R-RNO-983168); (R-RNO-9861718); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9931295); (R-RNO-9932298); (R-RNO-9954709); (R-RNO-9954716); (R-RNO-9958810); (R-RNO-9958825)", "pathway_count": 153, "publication_count": 3, "publication_id_list": "38843836;7488009;8031840", "class_list": "", "function": "Component of the 40S subunit of the ribosome. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, UniProtKB]; The protein encoded by this gene is a fusion protein that contains ubiquitin at its N-terminus and ribosomal protein S27a at its C-terminus. When the human ortholog of this protein is expressed in yeast, it is processed post-translationally into two products, a free ubiquitin monomer and ribosomal protein S27a, a component of the 40S ribosomal subunit. There are multiple pseudogenes of this gene. There is a locus on chromosome 5 (GeneID:81777) that contains an intact copy of the open reading frame of this gene, that is likely to be the result of retrotransposition of an mRNA into the genome. The transcriptional status of this locus cannot be verified at the present time. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02248;P02249;P02250;P49664;P62989;Q29120;Q63446;Q91887;Q91888;Q9D2W3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006412 translation;GO:0019941 modification-dependent protein catabolic process;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62982-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QQS3-1", "uniprot_id": "OSCP1_RAT", "mass": 43313.0, "length": 379, "protein_name": "Protein OSCP1", "gene_name": "Lsm10; Oscp1", "organism": "Rat", "refseq_name": "protein OSCP1", "refseq_ac": "NP_001025094", "gene_names_uniprotkb": "Lsm10; Oscp1; Lsm10; Oscp1", "gene_names_refseq": "Oscp1; RGD1306596", "protein_names_uniprotkb": "Protein OSCP1", "protein_names_refseq": "organic solute carrier protein 1; protein OSCP1", "tax_id": 10116, "disease": "", "pathway": " (rno:362595); (rno:366468); (R-RNO-111367); (R-RNO-73856); (R-RNO-77588)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "16006562", "class_list": "", "function": "May be involved in drug clearance in the placenta., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0071208 histone pre-mRNA DCP binding;GO:0071209 U7 snRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009925 basal plasma membrane;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane;GO:0008380 RNA splicing;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4QQS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62752-1", "uniprot_id": "RL23A_RAT", "mass": 17695.0, "length": 156, "protein_name": "Large ribosomal subunit protein uL23", "gene_name": "Rpl23al6; Rpl23al9; Rpl23a", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL23", "refseq_ac": "NP_001101753", "gene_names_uniprotkb": "Rpl23al6; Rpl23al9; Rpl23a; AABR07021384.1; LOC108352551; LOC680441; Rpl23al4; Rpl23al9", "gene_names_refseq": "Rpl23a", "protein_names_uniprotkb": "Large ribosomal subunit protein uL23; 60S ribosomal protein L23a", "protein_names_refseq": "60S ribosomal protein L23a; large ribosomal subunit protein uL23", "tax_id": 10116, "disease": "", "pathway": " (rno:108352551); (rno:360572); (rno:680441); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 2, "publication_id_list": "38843836;8428950", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P29316;P39024;Q92774", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding;GO:1904841 TORC2 complex binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62752-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08849-1", "uniprot_id": "STX3_RAT", "mass": 33257.0, "length": 289, "protein_name": "Syntaxin-3", "gene_name": "Stx3", "organism": "Rat", "refseq_name": "syntaxin-3", "refseq_ac": "NP_112386", "gene_names_uniprotkb": "Stx3; Stx3a", "gene_names_refseq": "Stx3a; Stx3", "protein_names_uniprotkb": "Syntaxin-3", "protein_names_refseq": "syntaxin-3", "tax_id": 10116, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)", "pathway": " (rno:81802); (R-RNO-449836)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "24323579;26936588;29549124;7690687", "class_list": "", "function": "Kv2.1 forms reservoir clusters on the beta-cell plasma membrane and binds Syn-3 via its C-terminal C1b domain, which recruits newcomer insulin secretory granules into this large reservoir., [RefSeq, PubMed]; Munc18-2 and STX3 perform distinct, but complementary, functions to support, respectively, SG translocation and membrane fusion in mast cells., [RefSeq, PubMed]; Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles. Essential for survival of retinal photoreceetors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0050544 arachidonate binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0008284 positive regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0045785 positive regulation of cell adhesion;GO:2000010 positive regulation of protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08849-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83883-1", "uniprot_id": "RL36A_RAT", "mass": 12441.0, "length": 106, "protein_name": "Large ribosomal subunit protein eL42", "gene_name": "Rpl36al1; Rpl36a", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL42", "refseq_ac": "NP_001121537", "gene_names_uniprotkb": "Rpl36al1; Rpl36a; Rpl36al-ps5; Rpl36a; Rpl44", "gene_names_refseq": "Rpl36a", "protein_names_uniprotkb": "Large ribosomal subunit protein eL42; 60S ribosomal protein L36a; 60S ribosomal protein L44", "protein_names_refseq": "60S ribosomal protein L36a; 60S ribosomal protein L44; large ribosomal subunit protein eL42", "tax_id": 10116, "disease": "", "pathway": " (rno:292964); (rno:81769); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "3396452", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09896;P10661", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83883-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJP9-1", "uniprot_id": "SR1IP_RAT", "mass": 18049.0, "length": 153, "protein_name": "Protein SREK1IP1", "gene_name": "Srek1ip1-ps1; Srek1ip1", "organism": "Rat", "refseq_name": "protein SREK1IP1", "refseq_ac": "NP_001008374", "gene_names_uniprotkb": "Srek1ip1-ps1; Srek1ip1; LOC100362980; Sfrs12ip1; Srek1ip1-ps1; Srek1ip1", "gene_names_refseq": "P18srp; RGD1305356; Sfrs12ip1; Srek1ip1", "protein_names_uniprotkb": "Protein SREK1IP1; SFRS12-interacting protein 1; SREK1-interacting protein 1", "protein_names_refseq": "SFRS12-interacting protein 1; protein SFRS12IP1; protein SREK1IP1; splicing regulatory glutamine/lysine-rich protein 1 interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361888)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15456940", "class_list": "", "function": "Possible splicing regulator involved in the control of cellular survival., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RJP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5HZW5-1", "uniprot_id": "CD320_RAT", "mass": 27943.0, "length": 264, "protein_name": "CD320 antigen", "gene_name": "Cd320; Ndufa7", "organism": "Rat", "refseq_name": "CD320 antigen isoform 1 precursor", "refseq_ac": "NP_001014223", "gene_names_uniprotkb": "Cd320; Ndufa7; Cd320; Ndufa7", "gene_names_refseq": "Cd320; RGD1305860; TCblR", "protein_names_uniprotkb": "CD320 antigen; TCblR; Transcobalamin receptor", "protein_names_refseq": "CD320 antigen isoform 1 precursor; CD320 antigen-like; CD320 antigen; transcobalamin receptor", "tax_id": 10116, "disease": "methylmalonic acidemia due to transcobalamin receptor defect (Disease Ontology:DOID:0060741)", "pathway": " (rno:299643); (rno:362851)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]; Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as a costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008083 growth factor activity;GO:0031419 cobalamin binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I;GO:0012505 endomembrane system", "go_biological_process": "GO:0030890 positive regulation of B cell proliferation;GO:0015889 cobalamin transport;GO:0030656 regulation of vitamin metabolic process;GO:0031296 B cell costimulation;GO:0042773 ATP synthesis coupled electron transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5HZW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81827-1", "uniprot_id": "UP1_RAT", "mass": 10960.0, "length": 101, "protein_name": "Urinary protein 1", "gene_name": "Rup2l1", "organism": "Rat", "refseq_name": "urinary protein 1 precursor", "refseq_ac": "NP_001030122", "gene_names_uniprotkb": "Rup2l1; LOC680406", "gene_names_refseq": "Rup2; UP-1", "protein_names_uniprotkb": "Urinary protein 1; Liver regeneration-related protein LRRG05; UP-1; rUP-1", "protein_names_refseq": "RUP-1; Urinary protein 1; liver regeneration-related protein LRRG05; urinary protein 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:619560); (rno:680406)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11565799;11840564", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q53ZD7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P81827-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62919-1", "uniprot_id": "RL8_RAT", "mass": 28025.0, "length": 257, "protein_name": "Large ribosomal subunit protein uL2", "gene_name": "Commd5; Rpl8-ps7; Rpl8", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL2", "refseq_ac": "NP_001030088", "gene_names_uniprotkb": "Commd5; Rpl8-ps7; Rpl8; LOC100910472; Rpl8", "gene_names_refseq": "Rpl8", "protein_names_uniprotkb": "Large ribosomal subunit protein uL2; 60S ribosomal protein L8", "protein_names_refseq": "60S ribosomal protein L8; large ribosomal subunit protein uL2", "tax_id": 10116, "disease": "Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (rno:245974); (rno:26962); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-9629569); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 2, "publication_id_list": "12042320;1610349", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JMZ6;P25120", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:1990932 5.8S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:1990090 cellular response to nerve growth factor stimulus;GO:0002181 cytoplasmic translation;GO:0006351 DNA-templated transcription;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62919-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62425-1", "uniprot_id": "RL7A_RAT", "mass": 29996.0, "length": 266, "protein_name": "Large ribosomal subunit protein eL8", "gene_name": "AABR07003273.1; LOC134483817; LOC134486107; Rpl7a", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL8", "refseq_ac": "NP_001107863", "gene_names_uniprotkb": "AABR07003273.1; LOC134483817; LOC134486107; Rpl7a; LOC134483817; LOC134486107; Rpl7a", "gene_names_refseq": "Rpl7a", "protein_names_uniprotkb": "Large ribosomal subunit protein eL8; 60S ribosomal protein L7a", "protein_names_refseq": "60S ribosomal protein L7a; large ribosomal subunit protein eL8", "tax_id": 10116, "disease": "", "pathway": " (rno:134483817); (rno:134486107); (rno:296596); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 4, "publication_id_list": "12042320;18683930;2748341;398910", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]; Component of the ribosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11518", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0045202 synapse;GO:0005840 ribosome", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:1904401 cellular response to Thyroid stimulating hormone;GO:0000470 maturation of LSU-rRNA;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62425-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62250-1", "uniprot_id": "RS16_RAT", "mass": 16445.0, "length": 146, "protein_name": "Small ribosomal subunit protein uS9", "gene_name": "Rps16l1; Rps16", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS9", "refseq_ac": "NP_001162617", "gene_names_uniprotkb": "Rps16l1; Rps16; AABR07051796.1; LOC120093118; RGD1561137; Rps16", "gene_names_refseq": "Rps16", "protein_names_uniprotkb": "Small ribosomal subunit protein uS9; 40S ribosomal protein S16", "protein_names_refseq": "40S ribosomal protein S16; small ribosomal subunit protein uS9", "tax_id": 10116, "disease": "", "pathway": " (rno:140655); (rno:366030); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "2332055;38843836", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17008", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0015935 small ribosomal subunit", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006412 translation;GO:0097421 liver regeneration;GO:0006364 rRNA processing;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62250-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61928-1", "uniprot_id": "RL37_RAT", "mass": 11078.0, "length": 97, "protein_name": "Large ribosomal subunit protein eL37", "gene_name": "LOC120097744; Rpl37l2; Rpl37", "organism": "Rat", "refseq_name": "60S ribosomal protein L37", "refseq_ac": "NP_112368", "gene_names_uniprotkb": "LOC120097744; Rpl37l2; Rpl37; LOC120097744; Rpl37l1; Rpl37l4; Rpl37", "gene_names_refseq": "Rpl37l1; Rpl37", "protein_names_uniprotkb": "Large ribosomal subunit protein eL37; 60S ribosomal protein L37", "protein_names_refseq": "60S ribosomal protein L37; ribosomal protein L37-like1; ribosomal protein L37", "tax_id": 10116, "disease": "", "pathway": " (rno:120093056); (rno:81770); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 12, "publication_count": 3, "publication_id_list": "6350292;7588717;8484768", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02403;Q99883", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019838 growth factor binding;GO:0019843 rRNA binding;GO:0097371 MDM2/MDM4 family protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:1901798 positive regulation of signal transduction by p53 class mediator;GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P61928-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62912-1", "uniprot_id": "RL32_RAT", "mass": 15860.0, "length": 135, "protein_name": "Large ribosomal subunit protein eL32", "gene_name": "Dnah11; Rpl32", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL32", "refseq_ac": "NP_037358", "gene_names_uniprotkb": "Dnah11; Rpl32", "gene_names_refseq": "Rpl32", "protein_names_uniprotkb": "Large ribosomal subunit protein eL32; 60S ribosomal protein L32", "protein_names_refseq": "60S ribosomal protein L32; large ribosomal subunit protein eL32", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); atrioventricular septal defect (Disease Ontology:DOID:0050651); primary ciliary dyskinesia 7 (Disease Ontology:DOID:0110605)", "pathway": " (rno:117253); (rno:28298); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 12, "publication_count": 3, "publication_id_list": "20410138;3357790;38843836", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P02433;Q63ZV8", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0071549 cellular response to dexamethasone stimulus;GO:0097421 liver regeneration;GO:0002181 cytoplasmic translation;GO:0060294 cilium movement involved in cell motility;GO:0003351 epithelial cilium movement involved in extracellular fluid movement", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62912-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62853-1", "uniprot_id": "RS25_RAT", "mass": 13742.0, "length": 125, "protein_name": "Small ribosomal subunit protein eS25", "gene_name": "Rps25l2; Rps25l3; Rps25", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS25", "refseq_ac": "NP_001005528", "gene_names_uniprotkb": "Rps25l2; Rps25l3; Rps25; LOC685085; Rps25-ps11; Rps25", "gene_names_refseq": "Rps25", "protein_names_uniprotkb": "Small ribosomal subunit protein eS25; 40S ribosomal protein S25", "protein_names_refseq": "40S ribosomal protein S25; small ribosomal subunit protein eS25", "tax_id": 10116, "disease": "", "pathway": " (rno:122799); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 2, "publication_id_list": "12042320;1354961", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25111;Q3SYP7", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006364 rRNA processing;GO:0034198 cellular response to amino acid starvation;GO:0042274 ribosomal small subunit biogenesis;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62853-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U4F0-1", "uniprot_id": "RRP8_RAT", "mass": 51216.0, "length": 457, "protein_name": "Ribosomal RNA-processing protein 8", "gene_name": "Rrp8", "organism": "Rat", "refseq_name": "ribosomal RNA-processing protein 8", "refseq_ac": "NP_001008347", "gene_names_uniprotkb": "Rrp8", "gene_names_refseq": "RGD1308302; Rrp8", "protein_names_uniprotkb": "Ribosomal RNA-processing protein 8; 2.1.1.-; Cerebral protein 1 homolog", "protein_names_refseq": "cerebral protein 1 homolog; ribosomal RNA-processing protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:308911); (R-RNO-427359)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.-;2.3.1.286;2.1.1.-", "go_molecular_function": "GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005677 chromatin silencing complex;GO:0033553 rDNA heterochromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0097009 energy homeostasis;GO:0042149 cellular response to glucose starvation;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U4F0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34980-1", "uniprot_id": "PE2R3_RAT", "mass": 39942.0, "length": 365, "protein_name": "Prostaglandin E2 receptor EP3 subtype", "gene_name": "Ptger3", "organism": "Rat", "refseq_name": "prostaglandin E2 receptor EP3 subtype isoform 1", "refseq_ac": "NP_036836", "gene_names_uniprotkb": "Ptger3", "gene_names_refseq": "EP3R; EP3; Ptger3; Rep3; rEP3a; rEP3b", "protein_names_uniprotkb": "Prostaglandin E2 receptor EP3 subtype; PGE receptor EP3 subtype; PGE2 receptor EP3 subtype; Prostanoid EP3 receptor", "protein_names_refseq": "PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; prostaglandin E receptor 3 (subtype EP3); prostaglandin E2 receptor EP3 subtype isoform 1; prostaglandin E2 receptor EP3 subtype; prostanoid EP3 receptor", "tax_id": 10116, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); withdrawal disorder (Disease Ontology:DOID:0060001); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); xeroderma pigmentosum group B (Disease Ontology:DOID:0110850); trichothiodystrophy (Disease Ontology:DOID:0111866); photosensitive trichothiodystrophy 2 (Disease Ontology:DOID:0111869); Alzheimer's disease (Disease Ontology:DOID:10652); membranous glomerulonephritis (Disease Ontology:DOID:10976); asphyxia neonatorum (Disease Ontology:DOID:11088); leiomyoma (Disease Ontology:DOID:127); Down syndrome (Disease Ontology:DOID:14250); renovascular hypertension (Disease Ontology:DOID:1591); colon cancer (Disease Ontology:DOID:219); asthma (Disease Ontology:DOID:2841); Cockayne syndrome (Disease Ontology:DOID:2962); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:24929); (R-RNO-391908); (R-RNO-418594)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11006128;30084511;32165825;33694300;36531208;8076679;8135830;8393672;8919306", "class_list": "", "function": "Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion., [RefSeq, PubMed]; Receptor for prostaglandin E2 (PGE2) (PubMed:11006128, PubMed:8393672). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Receptor for prostaglandin E2 (PGE2). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for prostaglandin E2 (PGE2); ligand binding activates a signaling cascade via G(i) proteins that leads to the inhibition of adenylate cyclase., [UniProtKB, PubMed]; Receptor for prostaglandin E2 (PGE2); ligand binding can activate several distinct signaling cascades, resulting in activation or inhibition of adenylate cyclase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results show that prostaglandin E2, via actions of presynaptic EP3 receptors, potently depresses GABA release onto parvocellular neuroendocrine cells., [RefSeq, PubMed]; Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63194;Q64376", "ec_number_list": "", "go_molecular_function": "GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031965 nuclear membrane;GO:0043025 neuronal cell body;GO:0031526 brush border membrane", "go_biological_process": "GO:1901380 negative regulation of potassium ion transmembrane transport;GO:1904346 positive regulation of gastric mucosal blood circulation;GO:0001660 fever generation;GO:0060455 negative regulation of gastric acid secretion;GO:1903640 negative regulation of gastrin-induced gastric acid secretion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P34980-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7B8-1", "uniprot_id": "RNF44_RAT", "mass": 39228.0, "length": 350, "protein_name": "RING finger protein 44", "gene_name": "Rnf44", "organism": "Rat", "refseq_name": "RING finger protein 44 isoform 2", "refseq_ac": "NP_001019966", "gene_names_uniprotkb": "Rnf44", "gene_names_refseq": "Rnf44", "protein_names_uniprotkb": "RING finger protein 44", "protein_names_refseq": "RING finger protein 44 isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361212)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7B8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62521-1", "uniprot_id": "CCDC8_RAT", "mass": 69589.0, "length": 643, "protein_name": "Coiled-coil domain-containing protein 8", "gene_name": "Ccdc8", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 8", "refseq_ac": "NP_001009533", "gene_names_uniprotkb": "Ccdc8", "gene_names_refseq": "Ccdc8", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 8", "protein_names_refseq": "coiled-coil domain-containing protein 8; probable Coiled-coil domain-containing protein 8", "tax_id": 10116, "disease": "3-M syndrome (Disease Ontology:DOID:0060241)", "pathway": " (rno:494320); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9Z5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:1990393 3M complex", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0007088 regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62521-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KLY4-1", "uniprot_id": "RING2_RAT", "mass": 34242.0, "length": 308, "protein_name": "E3 ubiquitin-protein ligase RING2", "gene_name": "Rnf2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rnf2; Ring1b", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RING2; 2.3.2.27; RING finger protein 1B; RING finger protein 2; RING-type E3 ubiquitin transferase RING2; RING1b", "protein_names_refseq": "", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); developmental disorder of mental health (Disease Ontology:DOID:0060037); Luo-Schoch-Yamamoto syndrome (Disease Ontology:DOID:0070416); spina bifida (Disease Ontology:DOID:0080016); cancer (Disease Ontology:DOID:162); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (rno:304850); (R-RNO-2559580); (R-RNO-3108214); (R-RNO-3899300); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-8939243); (R-RNO-8943724); (R-RNO-8953750)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers. Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes. Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.24;2.1.1.367;2.1.1.356;2.7.11.1;2.3.2.-;2.3.2.27;1.1.1.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0071535 RING-like zinc finger domain binding;GO:0140862 histone H2AK119 ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0021510 spinal cord development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3B7U2-1", "uniprot_id": "TAF1A_RAT", "mass": 53021.0, "length": 453, "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit A", "gene_name": "Taf1a", "organism": "Rat", "refseq_name": "TATA box-binding protein-associated factor RNA polymerase I subunit A", "refseq_ac": "NP_001032281", "gene_names_uniprotkb": "Taf1a", "gene_names_refseq": "Taf1a", "protein_names_uniprotkb": "TATA box-binding protein-associated factor RNA polymerase I subunit A; TATA box-binding protein-associated factor 1A; TBP-associated factor 1A; Transcription initiation factor SL1/TIF-IB subunit A", "protein_names_refseq": "TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A; TATA box-binding protein-associated factor 1A; TATA box-binding protein-associated factor RNA polymerase I subunit A; TBP-associated factor 1A; transcription initiation factor SL1/TIF-IB subunit A", "tax_id": 10116, "disease": "", "pathway": " (rno:360893); (R-RNO-5250924); (R-RNO-73762); (R-RNO-73772); (R-RNO-73863)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "20075868", "class_list": "", "function": "Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005668 RNA polymerase transcription factor SL1 complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3B7U2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25236-1", "uniprot_id": "SEPP1_RAT", "mass": 43083.0, "length": 385, "protein_name": "Selenoprotein P", "gene_name": "Selenop", "organism": "Rat", "refseq_name": "selenoprotein P precursor", "refseq_ac": "NP_001077380", "gene_names_uniprotkb": "Selenop; Selp; Sepp1", "gene_names_refseq": "Selenop; Sepp1", "protein_names_uniprotkb": "Selenoprotein P; SeP", "protein_names_refseq": "seP; selenoprotein P precursor; selenoprotein P, plasma, 1", "tax_id": 10116, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199); Jacobsen Syndrome (Disease Ontology:DOID:0111723); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (rno:29360)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11821412;12911312;2037562;28465347;29636330;7637580;7931697", "class_list": "", "function": "A chromatin immunoprecipitation (ChIP) assay revealed that EPA decreases binding of SREBP-1c to the SELENOP promoter. Knockdown of Srebf1 resulted in a significant down-regulation of Selenop expression., [RefSeq, PubMed]; Mass spectrometric characterization of full-length protein and three isoforms shortened at the C terminus, [RefSeq, PubMed]; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis., [UniProtKB]; Selenoprotein P promotes the development of pulmonary hypertension by stimulating excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells., [RefSeq, PubMed]; This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in rat), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008430 selenium binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007626 locomotory behavior;GO:0040008 regulation of growth;GO:0007420 brain development;GO:0009791 post-embryonic development;GO:0010269 response to selenium ion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P25236-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51400-1", "uniprot_id": "RED1_RAT", "mass": 77925.0, "length": 711, "protein_name": "Double-stranded RNA-specific editase 1", "gene_name": "Adarb1", "organism": "Rat", "refseq_name": "double-stranded RNA-specific editase 1 isoform 2", "refseq_ac": "NP_001104525", "gene_names_uniprotkb": "Adarb1; Red1", "gene_names_refseq": "Adar2; Adarb1; Red1", "protein_names_uniprotkb": "Double-stranded RNA-specific editase 1; 3.5.4.37; RNA-editing deaminase 1; RNA-editing enzyme 1; dsRNA adenosine deaminase", "protein_names_refseq": "RNA editing deaminase of glutamate receptors; RNA-editing deaminase 1; RNA-editing enzyme 1; double stranded RNA specific deaminase RED1; double-stranded RNA-specific editase 1 isoform 2; double-stranded RNA-specific editase 1; dsRNA adenosine deaminase", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25367); (R-RNO-75102); (R-RNO-77042)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16472753;20501795;20946981;23139803;28082424;30559217;8559253", "class_list": "", "function": "Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently (By similarity). Can inhibit cell proliferation and migration and can stimulate exocytosis., [UniProtKB, PubMed, PubMed, PubMed]; Lower levels of ADAR2 in the nucleus of immature neurons than in mature neurons., [RefSeq, PubMed]; That activity-dependent regulation of ADAR2 proteostasis and GluK2 Q/R editing are key determinants of kainate receptors Publication Status: Online-Only, [RefSeq, PubMed]; The JNK1 pathway may be functionally linked to the nutrient-sensing actions of ADAR2-mediated RNA editing in professional secretory cells., [RefSeq, PubMed]; This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.4.37", "go_molecular_function": "GO:0003723 RNA binding;GO:0004000 adenosine deaminase activity;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0060384 innervation;GO:0050685 positive regulation of mRNA processing;GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P51400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3B7K9-1", "uniprot_id": "RUN3B_RAT", "mass": 44792.0, "length": 403, "protein_name": "RUN domain-containing protein 3B", "gene_name": "Rundc3b", "organism": "Rat", "refseq_name": "RUN domain-containing protein 3B isoform 1", "refseq_ac": "NP_001040581", "gene_names_uniprotkb": "Rundc3b", "gene_names_refseq": "Rundc3b", "protein_names_uniprotkb": "RUN domain-containing protein 3B", "protein_names_refseq": "RUN domain-containing protein 3B isoform 1; RUN domain-containing protein 3B", "tax_id": 10116, "disease": "", "pathway": " (rno:688590)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3B7K9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31232-1", "uniprot_id": "TAGL_RAT", "mass": 22603.0, "length": 201, "protein_name": "Transgelin", "gene_name": "Tagln", "organism": "Rat", "refseq_name": "transgelin", "refseq_ac": "NP_113737", "gene_names_uniprotkb": "Tagln; Sm22", "gene_names_refseq": "Sm22; Tagln", "protein_names_uniprotkb": "Transgelin; SM22-alpha; Smooth muscle protein 22-alpha", "protein_names_refseq": "SM22-alpha; smooth muscle 22 protein; smooth muscle protein 22-alpha; transgelin", "tax_id": 10116, "disease": "", "pathway": " (rno:25123)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "22673903;28419207;28525410;29393594;7954852;8359698;8508530", "class_list": "", "function": "Actin cross-linking/gelling protein., [UniProtKB]; CKII-SIRT1-SM22alpha acts in a loop to reinforce the expression of SM22alpha, which limits the inflammatory response in vascular smooth muscle cells., [RefSeq, PubMed]; SM22 concentrations were significantly elevated in rats from 4 hours of mesenteric ischemia onwards. Furthermore, SM22 plasma concentrations closely paralleled the histological increasing degree of intestinal smooth muscle damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0036120 cellular response to platelet-derived growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P31232-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U220-1", "uniprot_id": "TM254_RAT", "mass": 14290.0, "length": 123, "protein_name": "Transmembrane protein 254", "gene_name": "Tmem254", "organism": "Rat", "refseq_name": "transmembrane protein 254", "refseq_ac": "NP_001008298", "gene_names_uniprotkb": "Tmem254", "gene_names_refseq": "Fam213a; RGD1305689; Tmem254", "protein_names_uniprotkb": "Transmembrane protein 254", "protein_names_refseq": "family with sequence similarity 213, member A; homolog of C10orf57; transmembrane protein 254; transmembrane protein C10orf57 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:290529)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U220-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M807-1", "uniprot_id": "RNF5_RAT", "mass": 19837.0, "length": 180, "protein_name": "E3 ubiquitin-protein ligase RNF5", "gene_name": "Rnf5", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF5", "refseq_ac": "NP_001102495", "gene_names_uniprotkb": "Rnf5", "gene_names_refseq": "Rnf5", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF5; 2.3.2.27; RING finger protein 5", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF5; RING-type E3 ubiquitin transferase RNF5; ing finger protein 5 pseudogene; ring finger protein 5, E3 ubiquitin protein ligase", "tax_id": 10116, "disease": "", "pathway": " (rno:407784); (R-RNO-382556); (R-RNO-9931269)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase., [UniProtKB, UniProtKB]; Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin. Catalyzes ubiquitination of Salmonella type III secreted protein sopA. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6;3.6.4.6;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009617 response to bacterium;GO:0010507 negative regulation of autophagy;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5HZA6-1", "uniprot_id": "PPCEL_RAT", "mass": 83482.0, "length": 726, "protein_name": "Prolyl endopeptidase-like", "gene_name": "Prepl", "organism": "Rat", "refseq_name": "prolyl endopeptidase-like", "refseq_ac": "NP_001010951", "gene_names_uniprotkb": "Prepl", "gene_names_refseq": "Prepl; RGD1310143", "protein_names_uniprotkb": "Prolyl endopeptidase-like; 3.4.21.-; Prolylendopeptidase-like", "protein_names_refseq": "prolyl endopeptidase-like", "tax_id": 10116, "disease": "congenital myasthenic syndrome 22 (Disease Ontology:DOID:0080587)", "pathway": " (rno:298771)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Serine peptidase whose precise substrate specificity remains unclear (By similarity). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (By similarity). May play a role in the regulation of synaptic vesicle exocytosis (By similarity)., [UniProtKB, UniProtKB]; Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006508 proteolysis;GO:0043001 Golgi to plasma membrane protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5HZA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PPN7-1", "uniprot_id": "MITOK_RAT", "mass": 45813.0, "length": 410, "protein_name": "Mitochondrial potassium channel", "gene_name": "Ccdc51", "organism": "Rat", "refseq_name": "mitochondrial potassium channel", "refseq_ac": "NP_001014120", "gene_names_uniprotkb": "Ccdc51; Mitok", "gene_names_refseq": "Ccdc51; MITOK; RGD1311466", "protein_names_uniprotkb": "Mitochondrial potassium channel; Coiled-coil domain-containing protein 51; MITOK", "protein_names_refseq": "coiled-coil domain-containing protein 51; mitochondrial potassium channel", "tax_id": 10116, "disease": "", "pathway": " (rno:316008)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pore-forming subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with ATP-binding subunit ABCB8/MITOSUR of the mitoK(ATP) channel, mediates ATP-dependent K(+) currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0062156 mitochondrial ATP-gated potassium channel activity", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0062157 mitochondrial ATP-gated potassium channel complex", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:0071805 potassium ion transmembrane transport;GO:0140141 mitochondrial potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PPN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3B7T9-1", "uniprot_id": "RFIP1_RAT", "mass": 71143.0, "length": 648, "protein_name": "Rab11 family-interacting protein 1", "gene_name": "Rab11fip1", "organism": "Rat", "refseq_name": "rab11 family-interacting protein 1 isoform 1", "refseq_ac": "NP_001178484", "gene_names_uniprotkb": "Rab11fip1; Rcp", "gene_names_refseq": "RGD1562965; Rab11-FIP1; Rab11fip1", "protein_names_uniprotkb": "Rab11 family-interacting protein 1; Rab-coupling protein; Rab11-FIP1", "protein_names_refseq": "RAB11 family interacting protein 1 (class I); rab-coupling protein; rab11 family-interacting protein 1 isoform 1; rab11 family-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:498650)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20810886;22673903;29393594", "class_list": "", "function": "A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; An interaction with Rab11 is necessary for long-range targeting of beta1 integrins to the growth cone along axons and in neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0055037 recycling endosome", "go_biological_process": "GO:0070164 negative regulation of adiponectin secretion;GO:0015031 protein transport;GO:0045055 regulated exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3B7T9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PQR4-1", "uniprot_id": "RSRC2_RAT", "mass": 43891.0, "length": 376, "protein_name": "Arginine/serine-rich coiled-coil protein 2", "gene_name": "Rsrc2", "organism": "Rat", "refseq_name": "arginine/serine-rich coiled-coil protein 2 isoform 1", "refseq_ac": "NP_001014150", "gene_names_uniprotkb": "Rsrc2", "gene_names_refseq": "Rsrc2", "protein_names_uniprotkb": "Arginine/serine-rich coiled-coil protein 2", "protein_names_refseq": "arginine/serine-rich coiled-coil 2; arginine/serine-rich coiled-coil protein 2 isoform 1; arginine/serine-rich coiled-coil protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:360807)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47940-1", "uniprot_id": "RES18_RAT", "mass": 19480.0, "length": 175, "protein_name": "Regulated endocrine-specific protein 18", "gene_name": "Resp18", "organism": "Rat", "refseq_name": "regulated endocrine-specific protein 18 precursor", "refseq_ac": "NP_062151", "gene_names_uniprotkb": "Resp18", "gene_names_refseq": "Resp18", "protein_names_uniprotkb": "Regulated endocrine-specific protein 18", "protein_names_refseq": "regulated endocrine-specific protein 18 precursor", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); hypertension (Disease Ontology:DOID:10763); IgA glomerulonephritis (Disease Ontology:DOID:2986); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:50561)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17951542;22561140;29570433;34340197;8132649", "class_list": "", "function": "Deep transcriptomic profiling of Dahl salt-sensitive rat kidneys with mutant form of Resp18., [RefSeq, PubMed]; Findings suggest regulated endocrine-specific protein-18 ( Resp18) as a gene associated with the development of hypertension and renal disease., [RefSeq, PubMed]; May play a regulatory role in corticotroph cells., [UniProtKB, PubMed]; Resp18 gene expression varies with activation of the corpus ghrelin-secreting cells and the antral gastrin-secreting cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen;GO:0030141 secretory granule;GO:0043204 perikaryon;GO:0048237 rough endoplasmic reticulum lumen", "go_biological_process": "GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P47940-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63016-1", "uniprot_id": "PAX6_RAT", "mass": 46754.0, "length": 422, "protein_name": "Paired box protein Pax-6", "gene_name": "Pax6", "organism": "Rat", "refseq_name": "paired box protein Pax-6", "refseq_ac": "NP_037133", "gene_names_uniprotkb": "Pax6; Pax-6; Sey", "gene_names_refseq": "Pax6", "protein_names_uniprotkb": "Paired box protein Pax-6; Oculorhombin", "protein_names_refseq": "oculorhombin; paired box gene 6; paired box homeotic gene 6; paired box protein Pax-6", "tax_id": 10116, "disease": "Peters anomaly (Disease Ontology:DOID:0060673); leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 2 (Disease Ontology:DOID:0070373); foveal hypoplasia 1 (Disease Ontology:DOID:0070530); aniridia 1 (Disease Ontology:DOID:0070532); anterior segment dysgenesis 5 (Disease Ontology:DOID:0080610); cataract 27 (Disease Ontology:DOID:0110233); autosomal dominant keratitis (Disease Ontology:DOID:0111383); bilateral optic nerve hypoplasia (Disease Ontology:DOID:0111531); glucose intolerance (Disease Ontology:DOID:10603); microphthalmia (Disease Ontology:DOID:10629); juvenile glaucoma (Disease Ontology:DOID:1068); coloboma of optic nerve (Disease Ontology:DOID:11975); aniridia (Disease Ontology:DOID:12271); paranoid schizophrenia (Disease Ontology:DOID:1229); autistic disorder (Disease Ontology:DOID:12849); Smith-Lemli-Opitz syndrome (Disease Ontology:DOID:14692); transient cerebral ischemia (Disease Ontology:DOID:224); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); congenital nystagmus (Disease Ontology:DOID:9649)", "pathway": " (rno:25509)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11880342;24114637;24952136;29102934;29451327;29482641;30286322;31301380;38750454;7981749", "class_list": "", "function": "Four upregulated transcription factors Pax6, Tp73, Cebpd, and Spi1, appeared as potent regulators of chronic post-traumatic brain injury (TBI) gene expression. They regulate molecular networks contributing to post-injury secondary damage, including apoptosis and inflammation, strengthening the feasibility of therapeutically targeting these molecular networks even after the acute post-TBI period. Publication Status: Online-Only, [RefSeq, PubMed]; PAX6/CXCL14 regulatory axis promotes the repair of corneal injury by enhancing corneal epithelial cell proliferation. Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrate that the miR-365-PAX6 system regulates the conversion of astrocytes into neurons in the ischemic brain. Both exogenous expression of PAX6 and administration of miR-365 antagomir are likely to promote brain repair by enhancing neurogenesis in adult mammalian brain following ischemic injury., [RefSeq, PubMed]; Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats., [RefSeq, PubMed]; These results suggest that Pax6 immunoreactivity showed diverse patterns in the neurogenic zone after prenatal hypoxia and Pax6 has important effects on neurogenesis, [RefSeq, PubMed]; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity). Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1A5N7;P32117;P70601;Q62222;Q64037;Q6QHS5;Q701Q8", "ec_number_list": "", "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0061034 olfactory bulb mitral cell layer development;GO:0003322 pancreatic A cell development;GO:0009786 regulation of asymmetric cell division;GO:0021905 forebrain-midbrain boundary formation;GO:0048708 astrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P63016-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4R180-1", "uniprot_id": "ORC3_RAT", "mass": 81901.0, "length": 711, "protein_name": "Origin recognition complex subunit 3", "gene_name": "Orc3", "organism": "Rat", "refseq_name": "origin recognition complex subunit 3", "refseq_ac": "NP_001020453", "gene_names_uniprotkb": "Orc3; Orc3l", "gene_names_refseq": "Orc3l; Orc3", "protein_names_uniprotkb": "Origin recognition complex subunit 3", "protein_names_refseq": "origin recognition complex subunit 3", "tax_id": 10116, "disease": "", "pathway": " (rno:313138); (R-RNO-176187); (R-RNO-68616); (R-RNO-68689); (R-RNO-68949); (R-RNO-68962)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "20674557;29393594", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The data of this study suggested that ORC3 supports neuronal maturation by inhibiting the Rho signaling pathway, and mediates the differentiating activity of mGlu4 receptors in cultured cerebellar granule cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005656 nuclear pre-replicative complex;GO:0031261 DNA replication preinitiation complex;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005664 nuclear origin of replication recognition complex", "go_biological_process": "GO:0006275 regulation of DNA replication;GO:0006270 DNA replication initiation;GO:0061351 neural precursor cell proliferation;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4R180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3B7D2-1", "uniprot_id": "SPTC2_RAT", "mass": 62962.0, "length": 560, "protein_name": "Serine palmitoyltransferase 2", "gene_name": "Sptlc2", "organism": "Rat", "refseq_name": "serine palmitoyltransferase 2", "refseq_ac": "NP_001032174", "gene_names_uniprotkb": "Sptlc2; Lcb2; Pomt2", "gene_names_refseq": "LCB 2; Pomt2; SPT 2; Sptlc2", "protein_names_uniprotkb": "Serine palmitoyltransferase 2; 2.3.1.50; LCB 2; Long chain base biosynthesis protein 2; SPT 2; Serine-palmitoyl-CoA transferase 2", "protein_names_refseq": "long chain base biosynthesis protein 2; protein-O-mannosyltransferase 2; serine palmitoyltransferase 2; serine-palmitoyl-CoA transferase 2", "tax_id": 10116, "disease": "hereditary sensory and autonomic neuropathy type 1C (Disease Ontology:DOID:0070157); hereditary sensory and autonomic neuropathy type 1 (Disease Ontology:DOID:0070162); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (rno:366697); (R-RNO-1660661)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11816724;21994399;36828166", "class_list": "", "function": "Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Crucial for adipogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Marked upregulation of expression of both SPT subunits in actively proliferating cells in balloon-injured vessels(serine palmitoyltransferase 1)(serine palmitoyltransferase 2), [RefSeq, PubMed]; SPTLC2 ameliorates chondrocyte dysfunction and extracellular matrix metabolism disturbance in vitro and in vivo in osteoarthritis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LSV4", "ec_number_list": "2.3.1.50", "go_molecular_function": "GO:0004758 serine C-palmitoyltransferase activity;GO:0030170 pyridoxal phosphate binding", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0098554 cytoplasmic side of endoplasmic reticulum membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0046511 sphinganine biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3B7D2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3C2P8-1", "uniprot_id": "SPRE2_RAT", "mass": 46805.0, "length": 410, "protein_name": "Sprouty-related, EVH1 domain-containing protein 2", "gene_name": "Spred2", "organism": "Rat", "refseq_name": "sprouty-related, EVH1 domain-containing protein 2", "refseq_ac": "NP_001040559", "gene_names_uniprotkb": "Spred2", "gene_names_refseq": "Spred2", "protein_names_uniprotkb": "Sprouty-related, EVH1 domain-containing protein 2; Spred-2", "protein_names_refseq": "spred-2; sprouty-related, EVH1 domain-containing protein 2", "tax_id": 10116, "disease": "Noonan syndrome (Disease Ontology:DOID:3490); achondroplasia (Disease Ontology:DOID:4480)", "pathway": " (rno:305539); (R-RNO-5658442); (R-RNO-5658623)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17974561;22305891;23982388;25576668;33124763;34406574", "class_list": "", "function": "Cav 1.3 damages the osteogenic differentiation in osteoporotic rats by negatively regulating Spred 2-mediated autophagy-induced cell senescence., [RefSeq, PubMed]; Decreased expression of Sproutys and SPREDs during the terminal pseudoglandular stage may disrupt lung branching morphogenesis by interfering with epithelial-mesenchymal interactions contributing to PH., [RefSeq, PubMed]; MiR-140-3p regulates the osteogenic differentiation ability of bone marrow mesenchymal stem cells by targeting spred2-mediated autophagy., [RefSeq, PubMed]; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with the p85 subunit of phosphatidylinositol 3-kinase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005173 stem cell factor receptor binding;GO:0019901 protein kinase binding;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030658 transport vesicle membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:1902532 negative regulation of intracellular signal transduction;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3C2P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3MHU5-1", "uniprot_id": "RETR2_RAT", "mass": 57659.0, "length": 541, "protein_name": "Reticulophagy regulator 2", "gene_name": "Retreg2", "organism": "Rat", "refseq_name": "reticulophagy regulator 2", "refseq_ac": "NP_001094230", "gene_names_uniprotkb": "Retreg2; Fam134a", "gene_names_refseq": "Fam134a; RGD1306844; Retreg2", "protein_names_uniprotkb": "Reticulophagy regulator 2", "protein_names_refseq": "family with sequence similarity 134, member A; protein FAM134A; reticulophagy regulator 2", "tax_id": 10116, "disease": "", "pathway": " (rno:363252)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress. When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins. Required for collagen quality control in a LIR motif-independent manner., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140506 endoplasmic reticulum-autophagosome adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030574 collagen catabolic process;GO:0061709 reticulophagy;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3MHU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5K2P9-1", "uniprot_id": "POLS2_RAT", "mass": 94483.0, "length": 875, "protein_name": "Polyserase-2", "gene_name": "Prss36", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Prss36", "gene_names_refseq": "", "protein_names_uniprotkb": "Polyserase-2; 3.4.21.-; Polyserine protease 2; Serine protease 36", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15536082", "class_list": "", "function": "Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 6, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5K2P9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PQK1-1", "uniprot_id": "SEP10_RAT", "mass": 53039.0, "length": 456, "protein_name": "Septin-10", "gene_name": "Septin10", "organism": "Rat", "refseq_name": "septin-10", "refseq_ac": "NP_001014055", "gene_names_uniprotkb": "Septin10; Sept10", "gene_names_refseq": "Sept10; Septin10", "protein_names_uniprotkb": "Septin-10", "protein_names_refseq": "septin-10", "tax_id": 10116, "disease": "", "pathway": " (rno:309891)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)., [UniProtKB]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0015629 actin cytoskeleton;GO:0015630 microtubule cytoskeleton;GO:0031105 septin complex", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50237-1", "uniprot_id": "ST1C1_RAT", "mass": 35764.0, "length": 304, "protein_name": "Sulfotransferase 1C1", "gene_name": "Sult1c1; Sult1c3", "organism": "Rat", "refseq_name": "sulfotransferase 1C1", "refseq_ac": "NP_113920", "gene_names_uniprotkb": "Sult1c1; Sult1c3; St1c1", "gene_names_refseq": "HAST-I; St1c1; Stp2; Sult1a2; Sult1c1; Sult1c3", "protein_names_uniprotkb": "Sulfotransferase 1C1; 2.8.2.-; HAST-I; N-hydroxyarylamine sulfotransferase; ST1C1", "protein_names_refseq": "N-hydroxyarylamine sulfotransferase; N-hydroxylarylamine sulfotransferase; Phenol sulfotransferase 1c1; sulfotransferase 1C1-like; sulfotransferase 1C1; sulfotransferase family 1A, member 2; sulfotransferase family 1A, phenol-preferring, member 2; sulfotransferase family, cytosolic, 1C, member 1; sulfotransferase family, cytosolic, 1C, member 3; sulfotransferase, phenol preferring 2; sulphotransferase family cytosolic 1A phenol-preferring member 2", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (rno:65185)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;8033246;8227031", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M8B5", "ec_number_list": "", "go_molecular_function": "GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0004027 alcohol sulfotransferase activity;GO:0047704 bile-salt sulfotransferase activity;GO:0004062 aryl sulfotransferase activity;GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051923 sulfation;GO:0008203 cholesterol metabolic process;GO:0006805 xenobiotic metabolic process;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0006790 sulfur compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50237-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32736-1", "uniprot_id": "OPCM_RAT", "mass": 38068.0, "length": 345, "protein_name": "Opioid-binding protein/cell adhesion molecule", "gene_name": "Opcml", "organism": "Rat", "refseq_name": "opioid-binding protein/cell adhesion molecule isoform 1 precursor", "refseq_ac": "NP_446300", "gene_names_uniprotkb": "Opcml; Obcam", "gene_names_refseq": "Opcml", "protein_names_uniprotkb": "Opioid-binding protein/cell adhesion molecule; OBCAM; OPCML; Opioid-binding cell adhesion molecule", "protein_names_refseq": "OBCAM; opioid-binding cell adhesion molecule; opioid-binding protein/cell adhesion molecule isoform 1 precursor; opioid-binding protein/cell adhesion molecule", "tax_id": 10116, "disease": "ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (rno:116597); (R-RNO-163125)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1039/D0MO00044B;1339369;14596858;18729387;19943852;34106099;7891157", "class_list": "", "function": "Binds opioids in the presence of acidic lipids; probably involved in cell contact., [UniProtKB]; OBCAM is synthesized within the somata, attached to vasopressin neurosecretory granules, and transported to the dendrites. The subcellular localization of OBCAM is changed in an activity-dependent manner., [RefSeq, PubMed]; The results of this study suggested that OBCAM is responsible for controlling the cell proliferation and growth in cortical astrocytes, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 850, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "P32735;Q01653;Q01654", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0097440 apical dendrite", "go_biological_process": "GO:0051965 positive regulation of synapse assembly;GO:0060253 negative regulation of glial cell proliferation;GO:0051963 regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0045793 positive regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P32736-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U1Y1-1", "uniprot_id": "RAB34_RAT", "mass": 29103.0, "length": 259, "protein_name": "Ras-related protein Rab-34", "gene_name": "Rab34", "organism": "Rat", "refseq_name": "ras-related protein Rab-34", "refseq_ac": "NP_001012140", "gene_names_uniprotkb": "Rab34", "gene_names_refseq": "Rab34", "protein_names_uniprotkb": "Ras-related protein Rab-34; 3.6.5.2", "protein_names_refseq": "RAB34, member of RAS oncogene family; Ras-related protein RAB34; ras-related protein Rab-34", "tax_id": 10116, "disease": "orofaciodigital syndrome XX (Disease Ontology:DOID:0060962)", "pathway": " (rno:360571); (R-RNO-8873719)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19641095", "class_list": "", "function": "Mechanistic basis for high glucose-induced protein secretion is through interaction of munc13 and rab34, indicating a potentially critical role for this newly described pathway in the pathogenesis of DN., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB34 transports protein involved in the redistribution of lysosomes to the peri-Golgi region. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Involved in ciliogenesis (By similarity). In particular, it is required for early steps of the intracellular cilium assembly pathway initiated by trafficking and docking of ciliary vesicles to the centrioles in the cytoplasm, followed by axoneme formation in the cytoplasm. After axoneme elongation, the centrioles migrate close to the cell surface so that ciliary vesicles can fuse with the plasma membrane to expose cilia to the extracellular space (By similarity). It seems dispensable for ciliogenesis via the extracellular pathway where cilium assembly begins after migration and docking of the centriole to the plasma membrane (By similarity). Also acts as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;2.5.1.60;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031267 small GTPase binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0090382 phagosome maturation;GO:0006897 endocytosis;GO:0071333 cellular response to glucose stimulus;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U1Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28042-1", "uniprot_id": "SSBP_RAT", "mass": 17455.0, "length": 151, "protein_name": "Single-stranded DNA-binding protein, mitochondrial", "gene_name": "Ssbp1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ssbp1; Ssbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Single-stranded DNA-binding protein, mitochondrial; Mt-SSB; MtSSB; Single strand DNA-binding protein P16", "protein_names_refseq": "", "tax_id": 10116, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (rno:54304); (R-RNO-9837999); (R-RNO-9913635)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "2221914;8482537;9611270", "class_list": "", "function": "Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0090297 positive regulation of mitochondrial DNA replication;GO:0051289 protein homotetramerization;GO:0006260 DNA replication;GO:0007005 mitochondrion organization;GO:0051096 positive regulation of helicase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P28042-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P37727-1", "uniprot_id": "RAE1_RAT", "mass": 72480.0, "length": 650, "protein_name": "Rab proteins geranylgeranyltransferase component A 1", "gene_name": "Chm", "organism": "Rat", "refseq_name": "rab proteins geranylgeranyltransferase component A 1 isoform 1", "refseq_ac": "NP_058763", "gene_names_uniprotkb": "Chm; Rep1", "gene_names_refseq": "Chm", "protein_names_uniprotkb": "Rab proteins geranylgeranyltransferase component A 1; Choroideremia protein homolog; REP-1; Rab escort protein 1", "protein_names_refseq": "CHM, Rab escort protein 1; REP-1; choroideraemia protein homolog; choroideremia (Rab escort protein 1); choroideremia protein homolog; choroidermia; rab escort protein 1; rab proteins geranylgeranyltransferase component A 1 isoform 1; rab proteins geranylgeranyltransferase component A 1", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 34 (Disease Ontology:DOID:0081200); choroideremia (Disease Ontology:DOID:9821)", "pathway": " (rno:24942); (R-RNO-6803205); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11389151;11675392;12356470;12620235;15186776;1525821;18756270;8513495", "class_list": "", "function": "RabGGTase has evolved from a GGTase-I-like molecule that 'learned' to interact with a recycling factor (GDI) that, in turn, eventually gave rise to REP1., [RefSeq, PubMed]; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005968 Rab-protein geranylgeranyltransferase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006612 protein targeting to membrane;GO:0001568 blood vessel development;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P37727-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83732-1", "uniprot_id": "RL24_RAT", "mass": 17779.0, "length": 157, "protein_name": "Large ribosomal subunit protein eL24", "gene_name": "Rpl24", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL24", "refseq_ac": "NP_071960", "gene_names_uniprotkb": "Rpl24", "gene_names_refseq": "Rpl24", "protein_names_uniprotkb": "Large ribosomal subunit protein eL24; 60S ribosomal protein L24; L30", "protein_names_refseq": "60S ribosomal protein L24; L30; large ribosomal subunit protein eL24", "tax_id": 10116, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (rno:64307); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "38843836;8048931", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P38663", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0060041 retina development in camera-type eye;GO:0006412 translation;GO:0010458 exit from mitosis;GO:0021554 optic nerve development;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P83732-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BJQ7-1", "uniprot_id": "TADA1_RAT", "mass": 37476.0, "length": 335, "protein_name": "Transcriptional adapter 1", "gene_name": "Tada1", "organism": "Rat", "refseq_name": "transcriptional adapter 1", "refseq_ac": "NP_001033069", "gene_names_uniprotkb": "Tada1; Tada1l", "gene_names_refseq": "RGD1306774; Tada1l; Tada1", "protein_names_uniprotkb": "Transcriptional adapter 1; Transcriptional adapter 1-like protein", "protein_names_refseq": "transcriptional adapter 1-like protein; transcriptional adapter 1; transcriptional adaptor 1 (HFI1 homolog, yeast) like; transcriptional adaptor 1- like", "tax_id": 10116, "disease": "", "pathway": " (rno:360874)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probably involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000124 SAGA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FWT7-1", "uniprot_id": "UBCP1_RAT", "mass": 36867.0, "length": 318, "protein_name": "Ubiquitin-like domain-containing CTD phosphatase 1", "gene_name": "Ublcp1", "organism": "Rat", "refseq_name": "ubiquitin-like domain-containing CTD phosphatase 1 isoform 1", "refseq_ac": "NP_001014139", "gene_names_uniprotkb": "Ublcp1", "gene_names_refseq": "RGD1310386; Ublcp1", "protein_names_uniprotkb": "Ubiquitin-like domain-containing CTD phosphatase 1; 3.1.3.16; Nuclear proteasome inhibitor UBLCP1", "protein_names_refseq": "nuclear proteasome inhibitor UBLCP1; ubiquitin-like domain-containing CTD phosphatase 1 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:360514)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1. Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. Has also been reported to stimulate the proteolytic activity of the 26S proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.53;3.1.3.52;3.1.3.67;3.1.3.-;3.1.3.27;2.7.11.22;3.1.3.74", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:1904855 proteasome regulatory particle binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0032780 negative regulation of ATP-dependent activity;GO:0090364 regulation of proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FWT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QR83-1", "uniprot_id": "STRA6_RAT", "mass": 73763.0, "length": 670, "protein_name": "Receptor for retinol uptake STRA6", "gene_name": "Stra6", "organism": "Rat", "refseq_name": "receptor for retinol uptake STRA6", "refseq_ac": "NP_001025095", "gene_names_uniprotkb": "Stra6", "gene_names_refseq": "RGD1307551; Stra6", "protein_names_uniprotkb": "Receptor for retinol uptake STRA6; Retinol-binding protein receptor STRA6; Stimulated by retinoic acid gene 6 protein homolog", "protein_names_refseq": "receptor for retinol uptake STRA6; retinol-binding protein receptor STRA6; stimulated by retinoic acid 6; stimulated by retinoic acid gene 6 homolog; stimulated by retinoic acid gene 6 protein homolog", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); syndromic microphthalmia 9 (Disease Ontology:DOID:0111807); exfoliation syndrome (Disease Ontology:DOID:13641)", "pathway": " (rno:363071); (R-RNO-2453902)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0034632 retinol transmembrane transporter activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060323 head morphogenesis;GO:0030540 female genitalia development;GO:0043585 nose morphogenesis;GO:0048520 positive regulation of behavior;GO:0060900 embryonic camera-type eye formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QR83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1EHB3-1", "uniprot_id": "ATS7_RAT", "mass": 175814.0, "length": 1595, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7", "gene_name": "Adamts7", "organism": "Rat", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform 1", "refseq_ac": "NP_001040566", "gene_names_uniprotkb": "Adamts7", "gene_names_refseq": "ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B; Adamts7; COMPase", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 7; 3.4.24.-; ADAM-TS 7; ADAM-TS7; ADAMTS-7", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform 1; a disintegrin and metalloproteinase with thrombospondin motifs 7; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7", "tax_id": 10116, "disease": "", "pathway": " (rno:315879); (R-RNO-5173214)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16585064;19168437;21869572;25921940;26938210;31638262;31894258", "class_list": "", "function": "ADAMTS-7 and ADAMTS-12 expression were dramatically increased during disc degeneration., [RefSeq, PubMed]; ADAMTS-7 is the first metalloproteinase found to bind directly to and degrade COMP, [RefSeq, PubMed]; ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries., [RefSeq, PubMed]; Data demonstrates that ADAMTS-7 promotes VSMC proliferation both in vitro and in vivo. ADAMTS-7 may therefore serve as a novel therapeutic target for atherosclerosis and post-angioplasty restenosis, [RefSeq, PubMed]; In conclusion, the changes in the expression of lncRNAs, mRNAs and proteins (Adamts7, P2ry6, Dlx3 and TP53) may possibly affect endometrial receptivity in rats with endometriosis during the implantation window, probably resulting in implantation failure of the embryo., [RefSeq, PubMed]; Metalloprotease. Was previously shown to degrade COMP. However, a later study found no activity against COMP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study shows that elevated ADAMTS-7 levels may be involved in ventricular remodeling after acute myocardial infarction., [RefSeq, PubMed]; Upregulation of miR423 improves autologous vein graft restenosis via targeting ADAMTS7., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 3, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q1XD63", "ec_number_list": "2.4.1.221;3.4.24.87;3.4.24.-;3.4.24.82", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0071773 cellular response to BMP stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q1EHB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M7W4-1", "uniprot_id": "TMC5_RAT", "mass": 110718.0, "length": 965, "protein_name": "Transmembrane channel-like protein 5", "gene_name": "Tmc5", "organism": "Rat", "refseq_name": "transmembrane channel-like protein 5 isoform 2", "refseq_ac": "NP_001012216", "gene_names_uniprotkb": "Tmc5", "gene_names_refseq": "Tmc5", "protein_names_uniprotkb": "Transmembrane channel-like protein 5", "protein_names_refseq": "transmembrane channel-like gene family 5; transmembrane channel-like protein 5 isoform 2; transmembrane channel-like protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:365360)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008381 mechanosensitive monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M7W4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35284-1", "uniprot_id": "RAB12_RAT", "mass": 27271.0, "length": 243, "protein_name": "Ras-related protein Rab-12", "gene_name": "Rab12", "organism": "Rat", "refseq_name": "ras-related protein Rab-12", "refseq_ac": "NP_037149", "gene_names_uniprotkb": "Rab12; LOC100362985", "gene_names_refseq": "Rab12", "protein_names_uniprotkb": "Ras-related protein Rab-12; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-12-like; ras-related protein Rab-12", "tax_id": 10116, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); syndromic intellectual disability (Disease Ontology:DOID:0050888); myelodysplastic syndrome (Disease Ontology:DOID:0050908); Smith-McCort dysplasia (Disease Ontology:DOID:0060247); chronic myelomonocytic leukemia (Disease Ontology:DOID:0080188); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); leiomyoma (Disease Ontology:DOID:127); lung cancer (Disease Ontology:DOID:1324); Weaver syndrome (Disease Ontology:DOID:14731); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); endometriosis (Disease Ontology:DOID:289); invasive ductal carcinoma (Disease Ontology:DOID:3008); glioblastoma (Disease Ontology:DOID:3068); osteosarcoma (Disease Ontology:DOID:3347); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cholangiocarcinoma (Disease Ontology:DOID:4947); myelofibrosis (Disease Ontology:DOID:4971); renal Wilms' tumor (Disease Ontology:DOID:5176); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); B-cell lymphoma (Disease Ontology:DOID:707); malignant pleural mesothelioma (Disease Ontology:DOID:7474); abdominal aortic aneurysm (Disease Ontology:DOID:7693); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute megakaryocytic leukemia (Disease Ontology:DOID:8761); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25530); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1313420;15791598;22673903;26740112", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; We identified the small GTPase Rab12 as a novel regulator of mast cell secretory granule transport, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;2.5.1.60;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0005764 lysosome", "go_biological_process": "GO:0015031 protein transport;GO:0006914 autophagy;GO:0008333 endosome to lysosome transport;GO:0016239 positive regulation of macroautophagy;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35284-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53792-1", "uniprot_id": "SC5A2_RAT", "mass": 72962.0, "length": 670, "protein_name": "Sodium/glucose cotransporter 2", "gene_name": "Slc5a2", "organism": "Rat", "refseq_name": "sodium/glucose cotransporter 2", "refseq_ac": "NP_072112", "gene_names_uniprotkb": "Slc5a2; Sglt2", "gene_names_refseq": "Sglt2; Slc5a2", "protein_names_uniprotkb": "Sodium/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 2; Solute carrier family 5 member 2", "protein_names_refseq": "Na(+)/glucose cotransporter 2; low affinity Na-dependent glucose transporter (SGLT2); low affinity sodium-glucose cotransporter; sodium/glucose cotransporter 2; solute carrier family 5 (sodium/glucose cotransporter), member 2", "tax_id": 10116, "disease": "familial renal glucosuria (Disease Ontology:DOID:0070613); hypertension (Disease Ontology:DOID:10763); renal glycosuria (Disease Ontology:DOID:9432)", "pathway": " (rno:64522); (R-RNO-189200)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14506074;32896668;33806551;34789005;35466690;36708596;7493971", "class_list": "", "function": "Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (By similarity). Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:7493971). Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity (By similarity). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Enhanced Expression and Function of Renal SGLT2 (Sodium-Glucose Cotransporter 2) in Heart Failure: Role of Renal Nerves., [RefSeq, PubMed]; Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; In renovascular hypertension, angiotensin II induced SGLT2 via the AT1 receptor, which was evidenced at both the functional and expression levels, probably contributing to increased absorption of Na+ and thereby to the development of hypertension., [RefSeq, PubMed]; Preliminary mechanism of inhibitor of SGLT2 in fatty liver cold ischemia injury., [RefSeq, PubMed]; SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na(+) transport in Dahl SS rats., [RefSeq, PubMed]; SGLT2 is not expressed in pancreatic alpha- and beta-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005412 D-glucose:sodium symporter activity;GO:0046872 metal ion binding;GO:0055056 D-glucose transmembrane transporter activity;GO:0015151 alpha-glucoside transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:1902495 transmembrane transporter complex", "go_biological_process": "GO:0035623 renal D-glucose absorption;GO:1904659 D-glucose transmembrane transport;GO:0035811 negative regulation of urine volume;GO:0098719 sodium ion import across plasma membrane;GO:0036359 renal potassium excretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53792-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BJP6-1", "uniprot_id": "RRF2M_RAT", "mass": 85914.0, "length": 779, "protein_name": "Ribosome-releasing factor 2, mitochondrial", "gene_name": "Gfm2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gfm2; EFG2; Efg2; GFM2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosome-releasing factor 2, mitochondrial; 3.6.5.-; EF-G2mt; Elongation factor G 2, mitochondrial; RRF2mt; mEF-G 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 39 (Disease Ontology:DOID:0111475)", "pathway": " (rno:294672); (R-RNO-5419276)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.1.1.29;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005739 mitochondrion", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3SWT6-1", "uniprot_id": "PPE1_RAT", "mass": 73966.0, "length": 640, "protein_name": "Serine/threonine-protein phosphatase with EF-hands 1", "gene_name": "Ppef1", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase with EF-hands 1 isoform 1", "refseq_ac": "NP_001030107", "gene_names_uniprotkb": "Ppef1", "gene_names_refseq": "Ppef1", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase with EF-hands 1; 3.1.3.16; PPEF-1", "protein_names_refseq": "PPEF-1; protein phosphatase with EF hand calcium-binding domain 1; protein phosphatase, EF-hand calcium binding domain 1; serine/threonine-protein phosphatase with EF-hands 1 isoform 1; serine/threonine-protein phosphatase with EF-hands 1-like; serine/threonine-protein phosphatase with EF-hands 1", "tax_id": 10116, "disease": "", "pathway": " (rno:317498); (R-RNO-2514859)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dephosphorylates and destabilises PDCD5 to inhibit TP53/p53-mediated signaling (By similarity). May have a role in the recovery or adaptation response of photoreceptors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.53;3.1.3.52;3.1.3.67;3.1.3.-;3.1.3.27;2.7.11.22;3.1.3.74", "go_molecular_function": "GO:0005506 iron ion binding;GO:0030145 manganese ion binding;GO:0005509 calcium ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0050906 detection of stimulus involved in sensory perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5GH57-1", "uniprot_id": "XKR6_RAT", "mass": 70928.0, "length": 638, "protein_name": "XK-related protein 6", "gene_name": "Xkr6", "organism": "Rat", "refseq_name": "XK-related protein 6", "refseq_ac": "NP_001012042", "gene_names_uniprotkb": "Xkr6; Xrg6", "gene_names_refseq": "RGD1310719; XRG6; Xkr6", "protein_names_uniprotkb": "XK-related protein 6", "protein_names_refseq": "X Kell blood group precursor related family member 6 homolog; X-linked Kx blood group related 6; XK, Kell blood group complex subunit-related family, member 6; XK-related protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:305960)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0043652 engulfment of apoptotic cell;GO:0070782 phosphatidylserine exposure on apoptotic cell surface;GO:1902742 apoptotic process involved in development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5GH57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PT56-1", "uniprot_id": "NTCP4_RAT", "mass": 46614.0, "length": 437, "protein_name": "Putative sodium/bile acid cotransporter 4", "gene_name": "Slc10a4", "organism": "Rat", "refseq_name": "putative sodium/bile acid cotransporter 4", "refseq_ac": "NP_001008555", "gene_names_uniprotkb": "Slc10a4", "gene_names_refseq": "Slc10a4", "protein_names_uniprotkb": "Putative sodium/bile acid cotransporter 4; Na(+)/bile acid cotransporter 4; Solute carrier family 10 member 4", "protein_names_refseq": "Na(+)/bile acid cotransporter 4; bile acid transporter Slc10a4; putative sodium/bile acid cotransporter 4; sodium/bile acid cotransporter 4; solute carrier family 10 (sodium/bile acid cotransporter family), member 4", "tax_id": 10116, "disease": "", "pathway": " (rno:305309)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18355966;21742018;23589386", "class_list": "", "function": "No significant bile acid transporter activity could be measured despite its similarity to bile acid:sodium symporters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The orphan carrier protein Slc10a4 expression in cholinergic neurons of the rat central nervous sys., [RefSeq, PubMed]; The results of this study suggested that Slc10a4 could be a novel vesicular transporter for cholinergic and/or various monoaminergic neurotransmitters in the central and peripheral nervous system. Erratum:[Neuroscience. 2012 Jun 14;212:226], [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0098981 cholinergic synapse;GO:0098691 dopaminergic synapse;GO:0099154 serotonergic synapse", "go_biological_process": "GO:0030534 adult behavior;GO:0015721 bile acid and bile salt transport;GO:0009410 response to xenobiotic stimulus;GO:0099162 regulation of neurotransmitter loading into synaptic vesicle;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5PT56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97616-1", "uniprot_id": "RED2_RAT", "mass": 82227.0, "length": 746, "protein_name": "Inactive double-stranded RNA-specific editase B2", "gene_name": "Adarb2", "organism": "Rat", "refseq_name": "inactive double-stranded RNA-specific editase B2", "refseq_ac": "NP_579836", "gene_names_uniprotkb": "Adarb2; Adar3; Red2", "gene_names_refseq": "Adar3; Adarb2; Red2", "protein_names_uniprotkb": "Inactive double-stranded RNA-specific editase B2; RNA-dependent adenosine deaminase 3; RNA-editing deaminase 2; RNA-editing enzyme 2; dsRNA adenosine deaminase B2", "protein_names_refseq": "RNA-dependent adenosine deaminase 3; RNA-editing deaminase 2; RNA-editing enzyme 2; adenosine deaminase 3, RNA dependent; double-stranded RNA-specific editase B2; dsRNA adenosine deaminase B2; inactive double-stranded RNA-specific editase B2", "tax_id": 10116, "disease": "", "pathway": " (rno:117088)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8943218", "class_list": "", "function": "Single- and double-stranded RNA-binding protein that interferes with the RNA editing activities of ADAR/ADAR1 and ADARB1/ADAR2. Likely competes with these proteins for target binding, repressing RNA editing across the transcriptome (PubMed:8943218). Additionally, it binds and stabilizes specific mRNAs and regulates the expression of proteins such as MAVS, DUSP1, and EGR1, independently of RNA editing mechanisms (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0140610 RNA sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0090367 negative regulation of mRNA modification;GO:0006382 adenosine to inosine editing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97616-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8F7-1", "uniprot_id": "CCD63_RAT", "mass": 66107.0, "length": 559, "protein_name": "Coiled-coil domain-containing protein 63", "gene_name": "Ccdc63", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 63 isoform 1", "refseq_ac": "NP_001020836", "gene_names_uniprotkb": "Ccdc63", "gene_names_refseq": "Ccdc63", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 63", "protein_names_refseq": "coiled-coil domain-containing protein 63 isoform 1; coiled-coil domain-containing protein 63", "tax_id": 10116, "disease": "", "pathway": " (rno:304484)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme", "go_biological_process": "GO:0007286 spermatid development;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8F7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42260-1", "uniprot_id": "GRIK2_RAT", "mass": 102470.0, "length": 908, "protein_name": "Glutamate receptor ionotropic, kainate 2", "gene_name": "Grik2", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, kainate 2 precursor", "refseq_ac": "NP_062182", "gene_names_uniprotkb": "Grik2; Glur6", "gene_names_refseq": "GluK2; GluR6; Grik2", "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 2; GluK2; GluR-6; GluR6; Glutamate receptor 6", "protein_names_refseq": "gluR-6; glutamate receptor 6; glutamate receptor ionotropic, kainate 2 precursor; glutamate receptor, ionotropic, kainate 2", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 6 (Disease Ontology:DOID:0081182); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:54257); (R-RNO-451307); (R-RNO-451308)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "11744724;1322826;15677325;15721240;1648177;17062563;17115050;17486098;19217376;21791290;22509486;22522402;25139762;31628192;33537798;37544581;38778115;38843836;39592599;7678465;7681676;8163463", "class_list": "", "function": "Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (By similarity). Functions in dorsal root ganglion neurons (By similarity)., [UniProtKB, UniProtKB]; Intrathecal injection of ozone alleviates CCIinduced neuropathic pain via the GluR6NFkappaB/p65 signalling pathway in rats., [RefSeq, PubMed]; Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid (PubMed:1648177, PubMed:1322826, PubMed:7681676, PubMed:7678465, PubMed:39592599, PubMed:38778115). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system (PubMed:1322826, PubMed:17486098, PubMed:25139762). Binding of the excitatory neurotransmitter L-glutamate induces a conformational change leading to the opening of the cation channel, converting the chemical signal to an electrical impulse (PubMed:39592599, PubMed:38778115). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:1322826, PubMed:1648177, PubMed:17115050, PubMed:17486098, PubMed:25139762, PubMed:7678465, PubMed:7681676, PubMed:8163463). Modulates cell surface expression of NETO2 (By similarity). In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; NETO2-GluK2 interaction contributes to postoperative pain hypersensitivity through inducing PKCgamma activation and synaptic incorporation of AMPA receptor GluR1 subunits in rat dorsal horn., [RefSeq, PubMed]; Neto1 and Neto2 differentially regulate GluK2 fast gating kinetics, [RefSeq, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 7, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 4, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.8.-.-", "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0030165 PDZ domain binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0006886 intracellular protein transport;GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential;GO:0048169 regulation of long-term neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P42260-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJS9-1", "uniprot_id": "RPF1_RAT", "mass": 39381.0, "length": 345, "protein_name": "Ribosome production factor 1", "gene_name": "Rpf1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rpf1; Bxdc5", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosome production factor 1; Brix domain-containing protein 5; Ribosome biogenesis protein RPF1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be required for ribosome biogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35763-1", "uniprot_id": "PERF_RAT", "mass": 61513.0, "length": 554, "protein_name": "Perforin-1", "gene_name": "Prf1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Prf1; Pfp", "gene_names_refseq": "", "protein_names_uniprotkb": "Perforin-1; Cytolysin; Lymphocyte pore-forming protein; P1", "protein_names_refseq": "", "tax_id": 10116, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); familial hemophagocytic lymphohistiocytosis 2 (Disease Ontology:DOID:0110922); aplastic anemia (Disease Ontology:DOID:12449); Fanconi anemia (Disease Ontology:DOID:13636); colon carcinoma (Disease Ontology:DOID:1520); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); non-Langerhans-cell histiocytosis (Disease Ontology:DOID:4330); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); chronic fatigue syndrome (Disease Ontology:DOID:8544); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2809217", "class_list": "", "function": "Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes. Facilitates the delivery of cationic cargo protein, while anionic or neural proteins are not delivered efficiently. Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0022829 wide pore channel activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031904 endosome lumen;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0051712 positive regulation of killing of cells of another organism;GO:0002418 immune response to tumor cell;GO:0045471 response to ethanol;GO:0051260 protein homooligomerization;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35763-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P85969-1", "uniprot_id": "SNAB_RAT", "mass": 33470.0, "length": 297, "protein_name": "Beta-soluble NSF attachment protein", "gene_name": "Napb", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Napb; Snapb", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachment protein beta; SNAP-beta", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 107 (Disease Ontology:DOID:0070393); Alzheimer's disease (Disease Ontology:DOID:10652); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (rno:499903); (R-RNO-204005); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811438); (R-RNO-6811440)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "19343716", "class_list": "", "function": "Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6K7C6", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005483 soluble NSF attachment protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0006886 intracellular protein transport;GO:0035249 synaptic transmission, glutamatergic;GO:0002090 regulation of receptor internalization;GO:0010807 regulation of synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P85969-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27768-1", "uniprot_id": "TNNI2_RAT", "mass": 21328.0, "length": 182, "protein_name": "Troponin I, fast skeletal muscle", "gene_name": "Tnni2", "organism": "Rat", "refseq_name": "troponin I, fast skeletal muscle", "refseq_ac": "NP_058881", "gene_names_uniprotkb": "Tnni2; Trp1", "gene_names_refseq": "Tnni2", "protein_names_uniprotkb": "Troponin I, fast skeletal muscle; Troponin I, fast-twitch isoform", "protein_names_refseq": "troponin 1, type 2; troponin I type 2 (skeletal, fast); troponin I, fast skeletal muscle; troponin I, skeletal, fast 2", "tax_id": 10116, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); distal arthrogryposis type 2B1 (Disease Ontology:DOID:0111600); heart disease (Disease Ontology:DOID:114); dilated cardiomyopathy (Disease Ontology:DOID:12930); adenocarcinoma (Disease Ontology:DOID:299)", "pathway": " (rno:29389); (R-RNO-390522)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14673191;20455213;22673903;28864299", "class_list": "", "function": "Release of fast sTnI consistent with load-induced injury of fast glycolytic fibres of inspiratory muscles, probably diaphragm. May provide insights into molecular basis of respiratory muscle dysfunction. Marker of respiratory muscle fatigue., [RefSeq, PubMed]; The effects of reactive oxygen species on tryptophan residues in alpha skeletal actin and troponin I, was investigated., [RefSeq, PubMed]; Troponin I interaction with calcium and Troponin C in cardiac muscle, [RefSeq, PubMed]; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031014 troponin T binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0045893 positive regulation of DNA-templated transcription;GO:0060048 cardiac muscle contraction;GO:0090076 relaxation of skeletal muscle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P27768-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07257-1", "uniprot_id": "TGFB2_RAT", "mass": 50534.0, "length": 442, "protein_name": "Transforming growth factor beta-2 proprotein", "gene_name": "Tgfb2", "organism": "Rat", "refseq_name": "transforming growth factor beta-2 proprotein isoform 1 precursor", "refseq_ac": "NP_112393", "gene_names_uniprotkb": "Tgfb2", "gene_names_refseq": "TGF-B2; Tgfb2", "protein_names_uniprotkb": "Transforming growth factor beta-2 proprotein", "protein_names_refseq": "TGF beta 2 protein; TGF-beta-2; transforming growth factor beta-2 proprotein isoform 1 precursor; transforming growth factor beta-2 proprotein", "tax_id": 10116, "disease": "Loeys-Dietz syndrome (Disease Ontology:DOID:0050466); Camurati-Engelmann disease 2 (Disease Ontology:DOID:0061230); Loeys-Dietz syndrome 4 (Disease Ontology:DOID:0070233); colon carcinoma (Disease Ontology:DOID:1520); osteochondrodysplasia (Disease Ontology:DOID:2256); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); liver cirrhosis (Disease Ontology:DOID:5082); pancreatic adenosquamous carcinoma (Disease Ontology:DOID:5637); myocardial infarction (Disease Ontology:DOID:5844); colorectal cancer (Disease Ontology:DOID:9256); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:81809); (R-RNO-114608); (R-RNO-2129379); (R-RNO-2173789); (R-RNO-9839389)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10899565;11014222;26858265;31835434;34246804;35028925;38409639;38843836;8486763;8509457", "class_list": "", "function": "Beta-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs., [RefSeq, PubMed]; Betaglycan shedding serves a major role in TGF-beta2 signaling in Sertoli cells. Publication Status: Online-Only, [RefSeq, PubMed]; Maternal Perinatal Exposure to Dibutyl Phthalate Promotes Ovarian Dysfunction in Adult Female Offspring via Downregulation of TGF-beta2 and TGF-beta3., [RefSeq, PubMed]; Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal., [UniProtKB, UniProtKB]; Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TGFbeta2 mediates oxidative stress-induced epithelial-to-mesenchymal transition of bladder smooth muscle., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q63574;Q9QW26;Q9R281;Q9R298;Q9R2B8;Q9WUQ8", "ec_number_list": "", "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005768 endosome;GO:0009986 cell surface;GO:0030141 secretory granule", "go_biological_process": "GO:0030878 thyroid gland development;GO:1904888 cranial skeletal system development;GO:0046580 negative regulation of Ras protein signal transduction;GO:0060364 frontal suture morphogenesis;GO:1902256 regulation of apoptotic process involved in outflow tract morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q07257-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4L0E8-1", "uniprot_id": "RGS18_RAT", "mass": 27645.0, "length": 235, "protein_name": "Regulator of G protein signaling 18", "gene_name": "Rgs18", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 18", "refseq_ac": "NP_001040549", "gene_names_uniprotkb": "Rgs18", "gene_names_refseq": "Rgs18", "protein_names_uniprotkb": "Regulator of G protein signaling 18; RGS18", "protein_names_refseq": "regulator of G-protein signaling 18", "tax_id": 10116, "disease": "", "pathway": " (rno:289076); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15946253;22673903", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0008277 regulation of G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4L0E8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38659-1", "uniprot_id": "PDIA4_RAT", "mass": 72720.0, "length": 643, "protein_name": "Protein disulfide-isomerase A4", "gene_name": "Pdia4", "organism": "Rat", "refseq_name": "protein disulfide-isomerase A4 precursor", "refseq_ac": "NP_446301", "gene_names_uniprotkb": "Pdia4; Cabp2; Erp70", "gene_names_refseq": "ERp-72; Erp70; Erp72; Pdia4", "protein_names_uniprotkb": "Protein disulfide-isomerase A4; 5.3.4.1; CaBP2; Calcium-binding protein 2; ER protein 70; ER protein 72; ERp-72; ERp70; ERp72; Endoplasmic reticulum resident protein 70; Endoplasmic reticulum resident protein 72", "protein_names_refseq": "ER protein 70; ER protein 72; caBP2; calcium-binding protein 2; endoplasmic reticulum resident protein 70; endoplasmic reticulum resident protein 72; protein disulfide isomerase associated 4; protein disulfide isomerase related protein (calcium-binding protein, intestinal-related); protein disulfide-isomerase A4 precursor; protein disulfide-isomerase A4", "tax_id": 10116, "disease": "", "pathway": " (rno:116598)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12475965;19446521;34502162;8477750", "class_list": "", "function": "Here, we report the X-ray crystal structure of central non-catalytic domains of a specific isomerase, ERp72 (also called CaBP2 and protein disulfide-isomerase A4) from Rattus norvegicus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7S5", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum", "go_biological_process": "GO:1903334 positive regulation of protein folding;GO:0006457 protein folding;GO:0070527 platelet aggregation;GO:0034976 response to endoplasmic reticulum stress;GO:0072378 blood coagulation, fibrin clot formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38659-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55043-1", "uniprot_id": "RAD_RAT", "mass": 33038.0, "length": 306, "protein_name": "GTP-binding protein RAD", "gene_name": "Rrad", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rrad; Rad", "gene_names_refseq": "", "protein_names_uniprotkb": "GTP-binding protein RAD; RAD1; Ras associated with diabetes", "protein_names_refseq": "", "tax_id": 10116, "disease": "congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:83521)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-dependent L-type Ca(2+) currents. Regulates voltage-gated L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway (By similarity). Inhibits phosphorylation and activation of CAMK2D (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005516 calmodulin binding;GO:0005525 GTP binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030315 T-tubule", "go_biological_process": "GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P55043-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35434-1", "uniprot_id": "ATPD_RAT", "mass": 17595.0, "length": 168, "protein_name": "ATP synthase F(1) complex subunit delta, mitochondrial", "gene_name": "Atp5f1d", "organism": "Rat", "refseq_name": "ATP synthase F(1) complex subunit delta, mitochondrial precursor", "refseq_ac": "NP_620806", "gene_names_uniprotkb": "Atp5f1d; Atp5d", "gene_names_refseq": "Atp5d; Atp5f1d", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit delta, mitochondrial; ATP synthase F1 subunit delta; F-ATPase delta subunit", "protein_names_refseq": "ATP synthase F(1) complex subunit delta, mitochondrial precursor; ATP synthase F(1) complex subunit delta, mitochondrial; ATP synthase subunit delta, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit; F-ATPase delta subunit", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); mitochondrial complex V (ATP synthase) deficiency nuclear type 5 (Disease Ontology:DOID:0070463); Alzheimer's disease (Disease Ontology:DOID:10652); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:245965); (R-RNO-163210); (R-RNO-8949613)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "17575325;26446791", "class_list": "", "function": "Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0044877 protein-containing complex binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly;GO:0009060 aerobic respiration;GO:1904638 response to resveratrol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35434-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27435-1", "uniprot_id": "TRYB1_RAT", "mass": 30400.0, "length": 273, "protein_name": "Tryptase", "gene_name": "Tpsab1", "organism": "Rat", "refseq_name": "tryptase precursor", "refseq_ac": "NP_062195", "gene_names_uniprotkb": "Tpsab1; Mcp7; Mcpt7; Tpsb1", "gene_names_refseq": "Mcpt7; TPSB1; Tpsab1; rMCP-7", "protein_names_uniprotkb": "Tryptase; 3.4.21.59; Mast cell protease 7; Tryptase alpha/beta-1; Tryptase, skin; rMCP-7", "protein_names_refseq": "MMCP-7; mast cell protease 7; tryptase beta 1; tryptase precursor; tryptase, skin", "tax_id": 10116, "disease": "", "pathway": " (rno:54271)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1314562;2036367;21999702;29393594;8996238", "class_list": "", "function": "Tryptase can stimulate myoblast proliferation and this effect is part of a signaling cascade dependent on PAR-2 activation and on the downstream activation of COX-2. Publication Status: Online-Only, [RefSeq, PubMed]; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P27436", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0042629 mast cell granule;GO:1905368 peptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P27435-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30938-1", "uniprot_id": "SSR5_RAT", "mass": 39971.0, "length": 363, "protein_name": "Somatostatin receptor type 5", "gene_name": "Sstr5", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sstr5", "gene_names_refseq": "", "protein_names_uniprotkb": "Somatostatin receptor type 5; SS-5-R; SS5-R; SS5R", "protein_names_refseq": "", "tax_id": 10116, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); acute myelomonocytic leukemia (Disease Ontology:DOID:0081082); prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); bipolar disorder (Disease Ontology:DOID:3312); myelofibrosis (Disease Ontology:DOID:4971); nephrolithiasis (Disease Ontology:DOID:585); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25354); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1362243;21820437;7908405", "class_list": "", "function": "Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion;GO:0060124 positive regulation of growth hormone secretion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P30938-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50904-1", "uniprot_id": "RASA1_RAT", "mass": 115440.0, "length": 1038, "protein_name": "Ras GTPase-activating protein 1", "gene_name": "Rasa1", "organism": "Rat", "refseq_name": "ras GTPase-activating protein 1", "refseq_ac": "NP_037267", "gene_names_uniprotkb": "Rasa1; Rasa", "gene_names_refseq": "GAPX; GAP; Rasa1; Rasa; p120GAP; rasGAP", "protein_names_uniprotkb": "Ras GTPase-activating protein 1; GAP; GTPase-activating protein; Ras p21 protein activator; RasGAP; p120GAP", "protein_names_refseq": "GTPase-activating protein; RAS p21 protein activator (GTPase activating protein) 1; ras GTPase-activating protein 1", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); arteriovenous malformation (Disease Ontology:DOID:11294); neurodegenerative disease (Disease Ontology:DOID:1289); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); basal cell carcinoma (Disease Ontology:DOID:2513); brain edema (Disease Ontology:DOID:4724)", "pathway": " (rno:25676); (R-RNO-186763); (R-RNO-3928662); (R-RNO-5218921); (R-RNO-5658442); (R-RNO-8849471)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "20933506;34165173;8262392", "class_list": "", "function": "GTPase-activating protein (GAP) that stimulates the intrinsic GTPase activity of Ras proteins, such as NRAS, facilitating their transition from the active GTP-bound state to the inactive GDP-bound state, thereby terminating Ras signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibition of lncRNA SNHG8 plays a protective role in hypoxia-ischemia-reoxygenation-induced myocardial injury by regulating miR-335 and RASA1 expression., [RefSeq, PubMed]; MiR-335 can be involved in the epididymal development by affecting the expression of RASA1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0001784 phosphotyrosine residue binding;GO:0005096 GTPase activator activity;GO:0005102 signaling receptor binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0001726 ruffle", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0007155 cell adhesion;GO:0007162 negative regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50904-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DWV2-1", "uniprot_id": "CADH7_RAT", "mass": 87270.0, "length": 785, "protein_name": "Cadherin-7", "gene_name": "Cdh7", "organism": "Rat", "refseq_name": "cadherin-7 precursor", "refseq_ac": "NP_001012755", "gene_names_uniprotkb": "Cdh7; Cad7", "gene_names_refseq": "Cad7; Cdh7", "protein_names_uniprotkb": "Cadherin-7", "protein_names_refseq": "Cadherin7; cadherin 7, type 2; cadherin-7 precursor", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:29162); (R-RNO-418990)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18801203", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Expression of cad7 and cad20 demarcates the compartments, boundaries, progenitor domains, specific nuclei and specific neural circuits during mammalian brain development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5DWV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25286-1", "uniprot_id": "VPP1_RAT", "mass": 96328.0, "length": 838, "protein_name": "V-type proton ATPase 116 kDa subunit a 1", "gene_name": "Atp6v0a1", "organism": "Rat", "refseq_name": "V-type proton ATPase 116 kDa subunit a 1", "refseq_ac": "NP_113792", "gene_names_uniprotkb": "Atp6v0a1; Atp6n1; Vpp1", "gene_names_refseq": "Atp6n1a; Atp6n1; Atp6v0a1", "protein_names_uniprotkb": "V-type proton ATPase 116 kDa subunit a 1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; V-ATPase 116 kDa subunit a 1; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1", "protein_names_refseq": "ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD); ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa); ATPase, H+ transporting, lysosomal V0 subunit A1; ATPase, H+ transporting, lysosomal V0 subunit a; ATPase, H+ transporting, lysosomal noncatalytic accessory protein 1a; V-ATPase 116 kDa subunit a 1; V-ATPase 116 kDa subunit a1; V-type proton ATPase 116 kDa subunit a 1; V-type proton ATPase 116 kDa subunit a1; V-type proton ATPase 116 kDa subunit a; clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; v-H+ATPase subunit a1; vacuolar adenosine triphosphatase subunit Ac116; vacuolar proton pump subunit 1; vacuolar proton translocating ATPase 116 kDa subunit a", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 104 (Disease Ontology:DOID:0070390); autosomal recessive osteopetrosis 1 (Disease Ontology:DOID:0110942); renal tubular acidosis (Disease Ontology:DOID:14219); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:29757); (R-RNO-1222556); (R-RNO-6798695); (R-RNO-77387); (R-RNO-917977); (R-RNO-983712)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "15935991;16621796;1704894;18683930;24165939;27323115;32165585;36232740;38843836", "class_list": "", "function": "Alternative splicing of exon N controls differential sorting of a1 variants to nerve terminals or distal dendrites, whereas exon C regulates their neuronal expression, [RefSeq, PubMed]; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase., [UniProtKB, UniProtKB, UniProtKB]; Mild hypothermia significantly increased V0a1 compared to NT-3 h; V0a1 expression was associated with a decrease in the cleaved caspase 3 expression. These findings suggested that mild hypothermia inhibits CA-induced apoptosis in the hippocampus, which may be associated with reduced V-ATPase impairment. Publication Status: Online-Only, [RefSeq, PubMed]; NGF-Induced Upregulation of CGRP in Orofacial Pain Induced by Tooth Movement Is Dependent on Atp6v0a1 and Vesicle Release. Publication Status: Online-Only, [RefSeq, PubMed]; Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles (PubMed:32165585). In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (PubMed:32165585). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Thus, our data demonstrate that the multiple fusion steps in GLUT4 trafficking have differential quantitative requirements for NSF activity., [RefSeq, PubMed]; V-ATPase membrane domain would allow the exocytotic machinery to discriminate fully loaded and acidified vesicles from vesicles undergoing neurotransmitter reloading., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043195 terminal bouton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0016241 regulation of macroautophagy;GO:0097401 synaptic vesicle lumen acidification;GO:0007035 vacuolar acidification", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P25286-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26342-1", "uniprot_id": "TGBR3_RAT", "mass": 94103.0, "length": 853, "protein_name": "Transforming growth factor beta receptor type 3", "gene_name": "Tgfbr3", "organism": "Rat", "refseq_name": "transforming growth factor beta receptor type 3 precursor", "refseq_ac": "NP_058952", "gene_names_uniprotkb": "Tgfbr3", "gene_names_refseq": "Tgfbr3; betaglycan", "protein_names_uniprotkb": "Transforming growth factor beta receptor type 3; Betaglycan; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; Transforming growth factor beta receptor III", "protein_names_refseq": "TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; transforming growth factor beta receptor type 3 precursor; transforming growth factor beta receptor type 3; transforming growth factor, beta receptor III", "tax_id": 10116, "disease": "endometrial adenocarcinoma (Disease Ontology:DOID:2870)", "pathway": " (rno:29610); (R-RNO-1502540); (R-RNO-190370); (R-RNO-190373); (R-RNO-201451); (R-RNO-2173789); (R-RNO-9839383); (R-RNO-9839389); (R-RNO-9839397); (R-RNO-9839406)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "1657406;1657407;21402931;25359088;30598510", "class_list": "", "function": "Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (By similarity). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (By similarity). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity)., [UniProtKB, PubMed, UniProtKB]; Data present the 2.0-A resolution crystal structure of the betaglycan ZP-C region in combination with a downstream region known as the external hydrophobic patch., [RefSeq, PubMed]; Identify the BGZP-C-binding site on TGF-beta2 and shed light on the specificity of BG for select TGF-beta-type GFs and the mechanisms by which BG influences their signaling, [RefSeq, PubMed]; Mating decreases plasma levels of TGFbeta1 and regulates myosalpinx expression of TGFbeta1/TGFBR3 in the rat., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0008201 heparin binding;GO:0015026 coreceptor activity;GO:0005160 transforming growth factor beta receptor binding;GO:0005024 transforming growth factor beta receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0010633 negative regulation of epithelial cell migration;GO:0060318 definitive erythrocyte differentiation;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P26342-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27952-1", "uniprot_id": "RS2_RAT", "mass": 31231.0, "length": 293, "protein_name": "Small ribosomal subunit protein uS5", "gene_name": "Rps2", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS5", "refseq_ac": "NP_114026", "gene_names_uniprotkb": "Rps2", "gene_names_refseq": "Rps2r1; Rps2", "protein_names_uniprotkb": "Small ribosomal subunit protein uS5; 40S ribosomal protein S2", "protein_names_refseq": "40S ribosomal protein S2; small ribosomal subunit protein uS5", "tax_id": 10116, "disease": "", "pathway": " (rno:83789); (R-RNO-156827); (R-RNO-1799339); (R-RNO-3214858); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-8876725); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 15, "publication_count": 2, "publication_id_list": "1939063;38843836", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity). Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G062", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0019899 enzyme binding;GO:0044877 protein-containing complex binding;GO:0017134 fibroblast growth factor binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:1990904 ribonucleoprotein complex;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0045471 response to ethanol;GO:0006412 translation;GO:0051443 positive regulation of ubiquitin-protein transferase activity;GO:0071353 cellular response to interleukin-4;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P27952-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28646-1", "uniprot_id": "SSR1_RAT", "mass": 42746.0, "length": 391, "protein_name": "Somatostatin receptor type 1", "gene_name": "Sstr1", "organism": "Rat", "refseq_name": "somatostatin receptor type 1", "refseq_ac": "NP_036851", "gene_names_uniprotkb": "Sstr1", "gene_names_refseq": "Gpcrrna; Sstr1", "protein_names_uniprotkb": "Somatostatin receptor type 1; SRIF-2; SS-1-R; SS1-R; SS1R", "protein_names_refseq": "RNGPCRRNA; SRIF-2; SS-1-R; SS1-R; SS1R; Somatostatin receptor subtype 1; somatostatin receptor type 1", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 21 with or without anosmia (Disease Ontology:DOID:0090093); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:25033); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1400442;1661599;24978951;25035058;25926390;29522573", "class_list": "", "function": "All SSTR1-5 proteins were observed at embryonal day 10 and increased with time in major structures, but the localization varied between the different subtypes. Only SSTR1 protein co-localized to a higher extent with the islet hormones studied., [RefSeq, PubMed]; In the jejunums of Cryptosporidium-parvum-infected rats, daily octreotide therapy decreased mRNA levels of SSTR1 on day 14 post-infection, although it increased mRNA levels of SSTR1 on day 50 post-infection. Specific SSTRs may regulate the inflammatory pathway in the rat intestinal inflammation model. Erratum:[PLoS One. 2018 May 24;13(5):e0198377. doi: 10.1371/journal.pone.0198377. PMID: 29795701] Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled to phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins., [UniProtKB]; This study demonistrated that sstr1 and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain., [RefSeq, PubMed]; Up-regulated SSTR1 contributed to neuronal apoptosis after intracerebral hemorrhage, which was accompanied with reduced expression of bcl-2., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection;GO:0038039 G protein-coupled receptor heterodimeric complex", "go_biological_process": "GO:0060125 negative regulation of growth hormone secretion;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007283 spermatogenesis;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P28646-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28648-1", "uniprot_id": "CD63_RAT", "mass": 25699.0, "length": 238, "protein_name": "CD63 antigen", "gene_name": "Cd63", "organism": "Rat", "refseq_name": "CD63 antigen", "refseq_ac": "NP_058821", "gene_names_uniprotkb": "Cd63", "gene_names_refseq": "Cd63", "protein_names_uniprotkb": "CD63 antigen; Mast cell antigen AD1", "protein_names_refseq": "CD63 antigen; mast cell antigen AD1", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); carotid artery disease (Disease Ontology:DOID:3407); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:29186); (R-RNO-114608); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1634775;1703158;30021215;30121936", "class_list": "", "function": "A disruption of cerebrospinal fluid exosomes in aged rats, evaluated by CD63 levels, can be related to susceptibility to neurodegenerative disorders., [RefSeq, PubMed]; Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data provide a previously uncharacterized trophic action of TIMP-1 to regulate oligodendrocyte maturation via a CD63/beta1-integrin/Akt pathway mechanism., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031904 endosome lumen;GO:0070062 extracellular exosome", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0010633 negative regulation of epithelial cell migration;GO:0015031 protein transport;GO:0016477 cell migration;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P28648-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29596-1", "uniprot_id": "ATF3_RAT", "mass": 20764.0, "length": 181, "protein_name": "Cyclic AMP-dependent transcription factor ATF-3", "gene_name": "Atf3", "organism": "Rat", "refseq_name": "cyclic AMP-dependent transcription factor ATF-3", "refseq_ac": "NP_037044", "gene_names_uniprotkb": "Atf3; Lrf1", "gene_names_refseq": "Atf3; LRF-1; LRFI", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-3; Activating transcription factor 3; LRF-1; Liver regeneration factor 1; cAMP-dependent transcription factor ATF-3", "protein_names_refseq": "cAMP-dependent transcription factor ATF-3; cyclic AMP-dependent transcription factor ATF-3-like; cyclic AMP-dependent transcription factor ATF-3; liver regeneration factor 1", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); pulmonary tuberculosis (Disease Ontology:DOID:2957)", "pathway": " (rno:25389)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1902565;19913522;35263513;36340581;37918704;37932484;38650141", "class_list": "", "function": "ATF3 Regulates Osteogenic Function by Mediating Osteoblast Ferroptosis in Type 2 Diabetic Osteoporosis. Publication Status: Online-Only, [RefSeq, PubMed]; ATF3/EGR1 regulates myocardial ischemia/reperfusion injury induced autophagy and inflammation in cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy., [RefSeq, PubMed]; MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage., [RefSeq, PubMed]; Protective role of activating transcription factor 3 against neuronal damage in rats with cerebral ischemia., [RefSeq, PubMed]; This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites (By similarity). It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0090575 RNA polymerase II transcription regulator complex;GO:1990622 CHOP-ATF3 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P29596-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30277-1", "uniprot_id": "CCNB1_RAT", "mass": 47391.0, "length": 423, "protein_name": "G2/mitotic-specific cyclin-B1", "gene_name": "Ccnb1", "organism": "Rat", "refseq_name": "G2/mitotic-specific cyclin-B1", "refseq_ac": "NP_741988", "gene_names_uniprotkb": "Ccnb1", "gene_names_refseq": "Ccnb1", "protein_names_uniprotkb": "G2/mitotic-specific cyclin-B1", "protein_names_refseq": "G2/mitotic-specific cyclin-B1", "tax_id": 10116, "disease": "linear skin defects with multiple congenital anomalies 2 (Disease Ontology:DOID:0111877); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovary epithelial cancer (Disease Ontology:DOID:2152); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (rno:25203); (R-RNO-174048); (R-RNO-176408); (R-RNO-176412); (R-RNO-176417); (R-RNO-2299718); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-2980767); (R-RNO-2995383); (R-RNO-3301854); (R-RNO-4419969); (R-RNO-6804114); (R-RNO-68875); (R-RNO-69273); (R-RNO-69478); (R-RNO-75035); (R-RNO-8852276)", "pathway_count": 18, "publication_count": 6, "publication_id_list": "22180637;25651564;26109654;31585531;8123599;8270434", "class_list": "", "function": "CCNB1 affects cavernous sinus invasion in pituitary adenomas through the epithelial-mesenchymal transition. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that cyclin A1 and cyclin B1 gene expression is controlled by E(2) at a concentration of 10(-9)uM only in stages IX-I of spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Essential for the control of the cell cycle at the G2/M (mitosis) transition (By similarity). Binds and activates cyclin-dependent protein kinase CDK1/CDC2 (By similarity)., [UniProtKB, UniProtKB]; Essential for the control of the cell cycle at the G2/M (mitosis) transition., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; That MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression, [RefSeq, PubMed]; These results unveil a previously unrecognized role for mitochondrial cyclin B1 in the oxidative damage associated with neurological disorders., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0035173 histone kinase activity;GO:0005113 patched binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005813 centrosome", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006468 protein phosphorylation;GO:0007283 spermatogenesis;GO:0010629 negative regulation of gene expression;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P30277-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31042-1", "uniprot_id": "CD28_RAT", "mass": 25170.0, "length": 218, "protein_name": "T-cell-specific surface glycoprotein CD28", "gene_name": "Cd28", "organism": "Rat", "refseq_name": "T-cell-specific surface glycoprotein CD28 precursor", "refseq_ac": "NP_037253", "gene_names_uniprotkb": "Cd28", "gene_names_refseq": "CD28RNA; Cd28", "protein_names_uniprotkb": "T-cell-specific surface glycoprotein CD28", "protein_names_refseq": "CD28 antigen; T-cell-specific surface glycoprotein CD28 precursor; T-cell-specific surface glycoprotein CD28", "tax_id": 10116, "disease": "immunodeficiency 123 (Disease Ontology:DOID:0061089); diabetic angiopathy (Disease Ontology:DOID:11713); leukemia (Disease Ontology:DOID:1240); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483); lymphopenia (Disease Ontology:DOID:614); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); chronic fatigue syndrome (Disease Ontology:DOID:8544); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:25660); (R-RNO-1257604); (R-RNO-389356); (R-RNO-389357); (R-RNO-389359); (R-RNO-6811558)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "1309509;22564625;24043548", "class_list": "", "function": "CD28 superagonist antibody treatment attenuated obliterative bronchiolitis in rat allo-orthotopic tracheal transplantation by preferentially expanding Foxp3-expressing regulatory T cells., [RefSeq, PubMed]; Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells., [UniProtKB, UniProtKB]; This study identified two crucial immune-related molecules-CD28 and NFATc1, as putative targets of miR-145 in human and experimental myasthenia gravis, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0015026 coreceptor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0001772 immunological synapse;GO:0098636 protein complex involved in cell adhesion", "go_biological_process": "GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P31042-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33533-1", "uniprot_id": "OPRD_RAT", "mass": 40450.0, "length": 372, "protein_name": "Delta-type opioid receptor", "gene_name": "Oprd1", "organism": "Rat", "refseq_name": "delta-type opioid receptor", "refseq_ac": "NP_036749", "gene_names_uniprotkb": "Oprd1; Ror-a", "gene_names_refseq": "Oprd1", "protein_names_uniprotkb": "Delta-type opioid receptor; D-OR-1; DOR-1; Opioid receptor A", "protein_names_refseq": "D-OR-1; DOR-1; delta-type opioid receptor; opioid receptor A", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); Carpenter syndrome (Disease Ontology:DOID:0060234); Carpenter syndrome 2 (Disease Ontology:DOID:0061099); opioid abuse (Disease Ontology:DOID:11206); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); opiate dependence (Disease Ontology:DOID:2559); myocardial infarction (Disease Ontology:DOID:5844); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24613); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "36592113;39155080;7519274;8394245", "class_list": "", "function": "Central delta/kappa opioid receptor signaling pathways mediate chronic and/or acute suckling-induced LH suppression in rats during late lactation., [RefSeq, PubMed]; Enkephalin-delta Opioid Receptor Signaling Mediates Glucoprivic Suppression of LH Pulse and Gluconeogenesis in Female Rats., [RefSeq, PubMed]; G protein-coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038046 G protein-coupled enkephalin receptor activity;GO:0004985 G protein-coupled opioid receptor activity;GO:0033612 receptor serine/threonine kinase binding;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043679 axon terminus;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0008344 adult locomotory behavior;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P33533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34975-1", "uniprot_id": "OPRK_RAT", "mass": 42688.0, "length": 380, "protein_name": "Kappa-type opioid receptor", "gene_name": "Oprk1", "organism": "Rat", "refseq_name": "kappa-type opioid receptor isoform 1", "refseq_ac": "NP_058863", "gene_names_uniprotkb": "Oprk1; Ror-d", "gene_names_refseq": "Oprk1", "protein_names_uniprotkb": "Kappa-type opioid receptor; K-OR-1; KOR-1", "protein_names_refseq": "K-OR-1; KOR-1; kappa-type opioid receptor isoform 1; kappa-type opioid receptor", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); opioid abuse (Disease Ontology:DOID:11206); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); opiate dependence (Disease Ontology:DOID:2559); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); neonatal abstinence syndrome (Disease Ontology:DOID:9828); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29335); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "20358363;37455648;39151827;39155080;7896774;8103466;8234341;8240267;8240268;8396539", "class_list": "", "function": "Central delta/kappa opioid receptor signaling pathways mediate chronic and/or acute suckling-induced LH suppression in rats during late lactation., [RefSeq, PubMed]; G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions., [UniProtKB, PubMed, PubMed]; Kappa opioid receptor mediated operant performance in male and female rats., [RefSeq, PubMed]; The role of miRNA-144-3p/Oprk1/KOR in nicotine dependence and nicotine withdrawal in male rats., [RefSeq, PubMed]; This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0038048 dynorphin receptor activity;GO:0033612 receptor serine/threonine kinase binding;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:1904000 positive regulation of eating behavior;GO:0006955 immune response;GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P34975-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35289-1", "uniprot_id": "RAB15_RAT", "mass": 24283.0, "length": 212, "protein_name": "Ras-related protein Rab-15", "gene_name": "Rab15", "organism": "Rat", "refseq_name": "ras-related protein Rab-15", "refseq_ac": "NP_942044", "gene_names_uniprotkb": "Rab15", "gene_names_refseq": "Rab15", "protein_names_uniprotkb": "Ras-related protein Rab-15; 3.6.5.2", "protein_names_refseq": "RAB15, member RAS onocogene family; ras-related protein Rab-15", "tax_id": 10116, "disease": "", "pathway": " (rno:299156); (R-RNO-8873719)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "1313420", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB15 may act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal (PubMed:1313420)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q504L6", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;2.5.1.60;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0048471 perinuclear region of cytoplasm;GO:0010008 endosome membrane", "go_biological_process": "GO:1903307 positive regulation of regulated secretory pathway;GO:0015031 protein transport;GO:0006898 receptor-mediated endocytosis;GO:0007269 neurotransmitter secretion;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35289-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35353-1", "uniprot_id": "CRHR1_RAT", "mass": 47842.0, "length": 415, "protein_name": "Corticotropin-releasing hormone receptor 1", "gene_name": "Crhr1", "organism": "Rat", "refseq_name": "corticotropin-releasing factor receptor 1 isoform 1 precursor", "refseq_ac": "NP_112261", "gene_names_uniprotkb": "Crhr1; Crhr", "gene_names_refseq": "CRF-R-1; CRF-R1; CRF-R; CRF1; CRFR-1; CRFR1; CRH-R 1; CRH-R-1; CRH-R1; CRH-R; Crhr1", "protein_names_uniprotkb": "Corticotropin-releasing hormone receptor 1; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1; Corticotropin-releasing factor receptor 1", "protein_names_refseq": "corticotrophin releasing hormone receptor 1; corticotropin releasing hormone 1; corticotropin-releasing factor receptor 1 isoform 1 precursor; corticotropin-releasing factor receptor 1", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); hypertension (Disease Ontology:DOID:10763); thromboangiitis obliterans (Disease Ontology:DOID:12918); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); functional colonic disease (Disease Ontology:DOID:3877); rhinitis (Disease Ontology:DOID:4483); type 2 diabetes mellitus (Disease Ontology:DOID:9352); irritable bowel syndrome (Disease Ontology:DOID:9778); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:58959); (R-RNO-373080)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11567096;23300088;34331656;35478009;36147561;8243338;8274282;8662941", "class_list": "", "function": "CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief., [RefSeq, PubMed]; G protein-coupled receptor for CRH and UCN stress hormones, which plays a central role in whole body adaptation to stress (PubMed:11567096, PubMed:8243338, PubMed:8274282). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors, such as adenylate cyclase (By similarity). CRHR1 is mainly coupled to G(s) G protein (GNAS), mediating activation of adenylate cyclase activity and production of cAMP (By similarity). In some conditions, can also couple to G(q) G protein (GNAQ) and mediate production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (By similarity). CRHR1-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (By similarity). Mediates both anxiogenic and anxiolytic response to stress in glutamatergic and dopaminergic neurons, respectively (By similarity). CRHR1 also plays a critical role in addiction by mediating the brain's stress response, particularly during withdrawal and relapse: it drives the transition to compulsive drug seeking by increasing anxiety and negative emotional states (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Moderate prenatal alcohol exposure modifies sex-specific CRFR1 activity in the central amygdala and anxiety-like behavior in adolescent offspring., [RefSeq, PubMed]; This gene encodes a member of the G-protein coupled receptor family. The encoded protein is a receptor for corticotropin-releasing factor (CRH) and urocortin (UCN). The interaction of this protein with CRH and UCN triggers G-protein coupled signaling. This protein plays a pivotal role in mediating the CRH-elicited effects in depression and anxiety. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0044877 protein-containing complex binding;GO:0001965 G-protein alpha-subunit binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0042277 peptide binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:2000252 negative regulation of feeding behavior;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P35353-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35370-1", "uniprot_id": "OPRX_RAT", "mass": 40523.0, "length": 367, "protein_name": "Nociceptin receptor", "gene_name": "Oprl1", "organism": "Rat", "refseq_name": "nociceptin receptor isoform 1", "refseq_ac": "NP_113757", "gene_names_uniprotkb": "Oprl1; Oor; Oprl", "gene_names_refseq": "KOR-3; KOR3; LC132; MOR-C; OFQR; ORL1; Oprl1; Oprl; XOR1", "protein_names_uniprotkb": "Nociceptin receptor; KOR-3; Kappa-type 3 opioid receptor; Orphanin FQ receptor; ROR-C; XOR1", "protein_names_refseq": "ROR-C; kappa-type 3 opioid receptor; nociceptin receptor ORL1; nociceptin receptor isoform 1; opiate receptor-like 1; opioid receptor-like 1; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; seven transmembrane G protein-coupled receptor", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); sciatic neuropathy (Disease Ontology:DOID:11446); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); cocaine abuse (Disease Ontology:DOID:809); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29256); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11290428;15937148;18588920;34285372;38338936;7798930;7877452;8026588;8034018;8034019;8163014", "class_list": "", "function": "G protein-coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin., [UniProtKB, PubMed, PubMed]; G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin., [UniProtKB, UniProtKB]; NOP receptor antagonism attenuates reinstatement of alcohol-seeking through modulation of the mesolimbic circuitry in male and female alcohol-preferring rats., [RefSeq, PubMed]; The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]., [RefSeq]; Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q791R4", "ec_number_list": "", "go_molecular_function": "GO:0001626 nociceptin receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0043005 neuron projection;GO:0097060 synaptic membrane", "go_biological_process": "GO:1904059 regulation of locomotor rhythm;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0019722 calcium-mediated signaling;GO:0035095 behavioral response to nicotine", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P35370-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35435-1", "uniprot_id": "ATPG_RAT", "mass": 30191.0, "length": 273, "protein_name": "ATP synthase F(1) complex subunit gamma, mitochondrial", "gene_name": "Atp5f1c; Taf3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Atp5f1c; Taf3; Atp5c1; Atp5c; Atp5f1c; Taf3", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit gamma, mitochondrial; ATP synthase F1 subunit gamma; F-ATPase gamma subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:116550); (R-RNO-163210); (R-RNO-8949613); (R-RNO-9837999)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "17575325;27213235;34502162;38843836;9736690", "class_list": "", "function": "Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit delta, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:0002039 p53 binding;GO:0140416 transcription regulator inhibitor activity;GO:0140002 histone H3K4me3 reader activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0071732 cellular response to nitric oxide;GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35435-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35446-1", "uniprot_id": "SPON1_RAT", "mass": 90773.0, "length": 807, "protein_name": "Spondin-1", "gene_name": "Spon1", "organism": "Rat", "refseq_name": "spondin-1 precursor", "refseq_ac": "NP_742064", "gene_names_uniprotkb": "Spon1; Sponf", "gene_names_refseq": "Spon1; Sponf", "protein_names_uniprotkb": "Spondin-1; F-spondin", "protein_names_refseq": "f-spondin; spondin 1, (f-spondin) extracellular matrix protein; spondin 1, extracellular matrix protein; spondin-1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:64456); (R-RNO-5173214)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14983046;1555244;16736493;17332427", "class_list": "", "function": "Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; F-spondin may be an endogenous regulator of APP cleavage., [RefSeq, PubMed]; These findings justify further investigation of this novel positional candidate gene in BP control in hypertensive rat models and humans., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050693 LBD domain binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:1902430 negative regulation of amyloid-beta formation;GO:0010954 positive regulation of protein processing;GO:1902993 positive regulation of amyloid precursor protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35446-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36940-1", "uniprot_id": "TNFL6_RAT", "mass": 31140.0, "length": 278, "protein_name": "Tumor necrosis factor ligand superfamily member 6", "gene_name": "Faslg", "organism": "Rat", "refseq_name": "tumor necrosis factor ligand superfamily member 6", "refseq_ac": "NP_037040", "gene_names_uniprotkb": "Faslg; Apt1Lg1; Cd95l; Fasl; Tnfsf6", "gene_names_refseq": "Apt1Lg1; CD95-L; Faslg; Fasl; Tnfsf6; Tnlg1a", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 6; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; Receptor-binding FasL ectodomain; SPA; SPPL2A-processed FasL form; Soluble Fas ligand; sFasL", "protein_names_refseq": "Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand); CD95 ligand; CD95L protein; Fas ligand (TNF superfamily, member 6); Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand); tumor necrosis factor ligand 1a; tumor necrosis factor ligand superfamily member 6", "tax_id": 10116, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); myelodysplastic syndrome (Disease Ontology:DOID:0050908); brain glioma (Disease Ontology:DOID:0060108); graft-versus-host disease (Disease Ontology:DOID:0081267); pre-eclampsia (Disease Ontology:DOID:10591); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); diabetic angiopathy (Disease Ontology:DOID:11713); leiomyoma (Disease Ontology:DOID:127); Huntington's disease (Disease Ontology:DOID:12858); HELLP syndrome (Disease Ontology:DOID:13133); lung cancer (Disease Ontology:DOID:1324); clonorchiasis (Disease Ontology:DOID:13767); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); substance-related disorder (Disease Ontology:DOID:303); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); invasive lobular carcinoma (Disease Ontology:DOID:3457); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); liver disease (Disease Ontology:DOID:409); seminoma (Disease Ontology:DOID:4440); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); cholangiocarcinoma (Disease Ontology:DOID:4947); congestive heart failure (Disease Ontology:DOID:6000); autoimmune lymphoproliferative syndrome (Disease Ontology:DOID:6688); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); chronic myeloid leukemia (Disease Ontology:DOID:8552); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:25385); (R-RNO-3371378); (R-RNO-5218900); (R-RNO-69416); (R-RNO-75157)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "31416448;31782491;33994507;34296305;37855249;7505205", "class_list": "", "function": "Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:7505205). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:7505205). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Cytoplasmic form induces gene transcription inhibition., [UniProtKB, UniProtKB]; FASLG was a target of miR-21 and revealed that FASLG knockdown inhibited function of endothelial progenitor cells. Publication Status: Online-Only, [RefSeq, PubMed]; Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process., [UniProtKB, UniProtKB]; Let-7a promotes periodontal bone regeneration of bone marrow mesenchymal stem cell aggregates via the Fas/FasL-autophagy pathway., [RefSeq, PubMed]; MiR-448-5p/VEGFA Axis Protects Cardiomyocytes from Hypoxia Through Regulating the FAS/FAS-L Signaling Pathway., [RefSeq, PubMed]; Prostaglandin E1 protects cardiomyocytes against hypoxia-reperfusion induced injury via the miR-21-5p/FASLG axis., [RefSeq, PubMed]; Upregulation of miR128 inhibits neuronal cell apoptosis following spinal cord injury via FasL downregulation by repressing ULK1., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005123 death receptor binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0030644 intracellular chloride ion homeostasis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P36940-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39032-1", "uniprot_id": "RL36_RAT", "mass": 12268.0, "length": 105, "protein_name": "Large ribosomal subunit protein eL36", "gene_name": "Rpl36", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL36", "refseq_ac": "NP_071949", "gene_names_uniprotkb": "Rpl36", "gene_names_refseq": "Rpl36", "protein_names_uniprotkb": "Large ribosomal subunit protein eL36; 60S ribosomal protein L36", "protein_names_refseq": "60S ribosomal protein L36; large ribosomal subunit protein eL36", "tax_id": 10116, "disease": "", "pathway": " (rno:58927); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "20410138;8484789;8981922", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDV5", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P39032-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41123-1", "uniprot_id": "RL13_RAT", "mass": 24309.0, "length": 211, "protein_name": "Large ribosomal subunit protein eL13", "gene_name": "Rpl13", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL13", "refseq_ac": "NP_112363", "gene_names_uniprotkb": "Rpl13", "gene_names_refseq": "Rpl13", "protein_names_uniprotkb": "Large ribosomal subunit protein eL13; 60S ribosomal protein L13", "protein_names_refseq": "60S ribosomal protein L13; large ribosomal subunit protein eL13", "tax_id": 10116, "disease": "spondyloepimetaphyseal dysplasia (Disease Ontology:DOID:0080027); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:81765); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "29393594;8198561", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0006412 translation;GO:0060348 bone development;GO:0097421 liver regeneration;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P41123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41413-1", "uniprot_id": "PCSK5_RAT", "mass": 201308.0, "length": 1809, "protein_name": "Proprotein convertase subtilisin/kexin type 5", "gene_name": "Pcsk5", "organism": "Rat", "refseq_name": "proprotein convertase subtilisin/kexin type 5 preproprotein", "refseq_ac": "NP_446275", "gene_names_uniprotkb": "Pcsk5", "gene_names_refseq": "PC6; Pc5; Pcsk5", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 5; 3.4.21.-; PC5; PC6; Proprotein convertase 5; Proprotein convertase 6; Subtilisin/kexin-like protease PC5; rPC5", "protein_names_refseq": "proprotein convertase 6; proprotein convertase subtilisin/kexin type 5 preproprotein; subtilisin/kexin-like protease PC5", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); sciatic neuropathy (Disease Ontology:DOID:11446); VACTERL association (Disease Ontology:DOID:14679); colon adenocarcinoma (Disease Ontology:DOID:234); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:116548); (R-RNO-167060); (R-RNO-8963889)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10749928;23686857;28975535;33313955;8341687;9013936", "class_list": "", "function": "Downregulation of Pcsk5 during cloaca development into the rectum and urethra might be related to the formation of anorectal malformations., [RefSeq, PubMed]; MicroRNA3383p regulates ageassociated osteoporosis via targeting PCSK5., [RefSeq, PubMed]; Overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner, [RefSeq, PubMed]; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D3ZVZ3;Q62914", "ec_number_list": "3.4.21.75;3.4.21.-;3.1.1.32;3.1.1.34", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0004866 endopeptidase inhibitor activity;GO:0042277 peptide binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0043204 perikaryon", "go_biological_process": "GO:0019058 viral life cycle;GO:1905609 positive regulation of smooth muscle cell-matrix adhesion;GO:0007507 heart development;GO:0016485 protein processing;GO:0016486 peptide hormone processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P41413-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P45446-2", "uniprot_id": "RORB_RAT", "mass": 53201.0, "length": 470, "protein_name": "Nuclear receptor ROR-beta", "gene_name": "Rorb", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rorb; Nr1f2; Rzrb", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear receptor ROR-beta; Nuclear receptor RZR-beta; Nuclear receptor subfamily 1 group F member 2; Retinoid-related orphan receptor-beta", "protein_names_refseq": "", "tax_id": 10116, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); autosomal dominant nonsyndromic deafness 83 (Disease Ontology:DOID:0070609); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (R-RNO-383280)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11689423;12958591;7935491;8816759;9670004;9729429", "class_list": "", "function": "Critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity)., [UniProtKB, UniProtKB]; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071300 cellular response to retinoic acid;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P45446-2", "record_type": "protein" }, { "uniprot_canonical_ac": "P47198-1", "uniprot_id": "RL22_RAT", "mass": 14789.0, "length": 128, "protein_name": "Large ribosomal subunit protein eL22", "gene_name": "Rpl22-ps2; Rpl22", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL22", "refseq_ac": "NP_112366", "gene_names_uniprotkb": "Rpl22-ps2; Rpl22; LOC100360057; Rpl22", "gene_names_refseq": "Rpl22", "protein_names_uniprotkb": "Large ribosomal subunit protein eL22; 60S ribosomal protein L22", "protein_names_refseq": "60S ribosomal protein L22; large ribosomal subunit protein eL22", "tax_id": 10116, "disease": "", "pathway": " (rno:81768); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "36038000;7999786", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0005840 ribosome", "go_biological_process": "GO:0046632 alpha-beta T cell differentiation;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P47198-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47752-1", "uniprot_id": "S1PR2_RAT", "mass": 38735.0, "length": 352, "protein_name": "Sphingosine 1-phosphate receptor 2", "gene_name": "S1pr2", "organism": "Rat", "refseq_name": "sphingosine 1-phosphate receptor 2", "refseq_ac": "NP_058888", "gene_names_uniprotkb": "S1pr2; Edg5", "gene_names_refseq": "Edg5; GPCR18; Gpcr13; H218; S1pr2; snGPCR18", "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 2; AGR16; Endothelial differentiation G protein-coupled receptor 5; G protein-coupled receptor H218; S1P receptor 2; S1P receptor Edg-5; S1P2; Sphingosine 1-phosphate receptor Edg-5", "protein_names_refseq": "AGR16; G-protein coupled receptor 13; G-protein coupled receptor H218; S1P receptor 2; S1P receptor Edg-5; S1P2; endothelial differentiation G-protein coupled receptor 5; endothelial differentiation, sphingolipid G-protein-coupled receptor, 5; sphingosine 1-phosphate receptor 2; sphingosine 1-phosphate receptor Edg-5", "tax_id": 10116, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); autosomal recessive nonsyndromic deafness 68 (Disease Ontology:DOID:0110519); carcinoma (Disease Ontology:DOID:305)", "pathway": " (rno:29415); (R-RNO-418594); (R-RNO-419408)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10383399;29453251;31603252;33452855;33880585;34224319;35263212;8087418;8382486;9409733", "class_list": "", "function": "Alteration of sphingosine-1-phosphate with aging induces contractile dysfunction of colonic smooth muscle cells via Ca(2+) -activated K(+) channel (BKCa ) upregulation., [RefSeq, PubMed]; Analysis of regulatory effect of miR-149-5p on Sphingosine-1-phosphate receptor 2 of pericytes and its neuroprotective molecular mechanism after acute cerebral ischemia reperfusion in rats., [RefSeq, PubMed]; Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats., [RefSeq, PubMed]; RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary neural repair through enhancing vascular autophagy in the thalamus after cerebral cortical infarction., [RefSeq, PubMed]; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10383399). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10383399). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (PubMed:29453251). In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal center (GC) B cell growth and migration outside the GC niche., [UniProtKB, PubMed, PubMed, UniProtKB]; Sphingosine-1-phosphate receptor 2 modulates pain sensitivity by suppressing the ROS-RUNX3 pathway in a rat model of neuropathy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q54AI6", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005178 integrin binding;GO:0001664 G protein-coupled receptor binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0038036 sphingosine-1-phosphate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0046847 filopodium assembly;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P47752-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47987-1", "uniprot_id": "PLLP_RAT", "mass": 19834.0, "length": 182, "protein_name": "Plasmolipin", "gene_name": "Pllp", "organism": "Rat", "refseq_name": "plasmolipin", "refseq_ac": "NP_071978", "gene_names_uniprotkb": "Pllp; Pmlp; Tm4sf11", "gene_names_refseq": "Pllp; Tm4sf11", "protein_names_uniprotkb": "Plasmolipin; Plasma membrane proteolipid", "protein_names_refseq": "plasma membrane proteolipid (plasmolipin); plasmolipin; transmembrane 4 superfamily member 11", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:64364)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12871592;22673903;7929173;8714710", "class_list": "", "function": "Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination (Probable). Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apical endocytosis (By similarity). Part of the intracellular machinery that mediates basolateral-to-apical transport of ICAM-1, an essential adhesion receptor in epithelial cells, from the subapical compartment in hepatic epithelial cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The proteolipid plasmolipin is a structural component of apical membranes of polarized cells; asymmetric distribution of plasmolipin in compact myelin, as well as in epithelial cells of kidney and stomach was noted, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019911 structural constituent of myelin sheath;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043209 myelin sheath;GO:0045121 membrane raft;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0030100 regulation of endocytosis;GO:0042552 myelination;GO:0032288 myelin assembly;GO:1904298 regulation of transcytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P47987-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48303-1", "uniprot_id": "S1PR1_RAT", "mass": 42746.0, "length": 383, "protein_name": "Sphingosine 1-phosphate receptor 1", "gene_name": "S1pr1", "organism": "Rat", "refseq_name": "sphingosine 1-phosphate receptor 1", "refseq_ac": "NP_058997", "gene_names_uniprotkb": "S1pr1; Edg1", "gene_names_refseq": "Edg1; S1pr1", "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 1; Endothelial differentiation G protein-coupled receptor 1; S1P receptor 1; S1P receptor Edg-1; S1P1; Sphingosine 1-phosphate receptor Edg-1", "protein_names_refseq": "EDG1 (Edg1); S1P receptor 1; S1P receptor Edg-1; S1P1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor Edg-1", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:29733); (R-RNO-419408)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "22673903;24090084;34516079;34773542;37083109;37851113;37880240;38843836;7959012", "class_list": "", "function": "G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury (By similarity)., [UniProtKB, UniProtKB]; In Vitro and In Vivo Investigation of S1PR1 Expression in the Central Nervous System Using [(3)H]CS1P1 and [(11)C]CS1P1., [RefSeq, PubMed]; LINC00707 inhibits myocardial fibrosis and immune disorder in rheumatic heart disease by regulating miR-145-5p/S1PR1., [RefSeq, PubMed]; Long non-coding RNA HOX transcript antisense intergenic RNA depletion protects against alcoholic hepatitis through the microRNA-148a-3p/sphingosine 1-phosphate receptor 1 axis., [RefSeq, PubMed]; Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities., [RefSeq, PubMed]; The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V7F6", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001664 G protein-coupled receptor binding;GO:0038036 sphingosine-1-phosphate receptor activity;GO:0046625 sphingolipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0045124 regulation of bone resorption;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0001525 angiogenesis;GO:0006935 chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P48303-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48961-1", "uniprot_id": "CCND3_RAT", "mass": 32434.0, "length": 293, "protein_name": "G1/S-specific cyclin-D3", "gene_name": "Ccnd3", "organism": "Rat", "refseq_name": "G1/S-specific cyclin-D3", "refseq_ac": "NP_036898", "gene_names_uniprotkb": "Ccnd3", "gene_names_refseq": "Ccnd3", "protein_names_uniprotkb": "G1/S-specific cyclin-D3", "protein_names_refseq": "G1/S-specific cyclin-D3", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); cervix carcinoma (Disease Ontology:DOID:2893); invasive ductal carcinoma (Disease Ontology:DOID:3008); ovary adenocarcinoma (Disease Ontology:DOID:3713); renal cell carcinoma (Disease Ontology:DOID:4450); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:25193); (R-RNO-5687128); (R-RNO-69231); (R-RNO-8934593); (R-RNO-9754119)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "19672123;20066559;22673903;25596037;7926809;8973324", "class_list": "", "function": "Dexamethasone induced placental and embryonal abnormalities which could be associated with reduced expressions of PCNA and cyclin D3, increased expressions of p27 and p57 and increased rate of apoptosis in IUGR placentas, [RefSeq, PubMed]; PGE(2) induces mesangial cell hypertrophy and cell cycle arrest via its EP1 receptor., [RefSeq, PubMed]; Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Role of cyclin D3/CDK11(p58) complex in repressing the Schwann cells proliferation and inducing its apoptosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63628", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P48961-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49430-1", "uniprot_id": "THAS_RAT", "mass": 59974.0, "length": 533, "protein_name": "Thromboxane-A synthase", "gene_name": "Tbxas1", "organism": "Rat", "refseq_name": "thromboxane-A synthase", "refseq_ac": "NP_036819", "gene_names_uniprotkb": "Tbxas1; Cyp5a1; Cyp5", "gene_names_refseq": "Tbxas1", "protein_names_uniprotkb": "Thromboxane-A synthase; 4.2.1.152; 5.3.99.5; Cytochrome P450 5A1; Hydroperoxy icosatetraenoate dehydratase; TXA synthase; TXS", "protein_names_refseq": "TXA synthase; TXS; ThromboxA ane synthase 1; cytochrome P450 5A1; hydroperoxy icosatetraenoate dehydratase; thromboxane A synthase 1, platelet; thromboxane-A synthase", "tax_id": 10116, "disease": "thrombosis (Disease Ontology:DOID:0060903); alcohol-associated liver disease (Disease Ontology:DOID:0070658); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Ghosal hematodiaphyseal syndrome (Disease Ontology:DOID:0112251); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); hydronephrosis (Disease Ontology:DOID:11111); arteriosclerosis (Disease Ontology:DOID:2349); glomerulonephritis (Disease Ontology:DOID:2921); brain infarction (Disease Ontology:DOID:3454); cerebral infarction (Disease Ontology:DOID:3526); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (rno:24886); (R-RNO-211979); (R-RNO-2162123)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "26211743;29393594;8131852;9261862", "class_list": "", "function": "Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE., [UniProtKB, UniProtKB]; TBXAS1 gene expression was downregulated in rats with iron-induced mesothelioma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.152;5.4.4.7;5.3.99.3;1.14.14.1;1.14.99.1;5.3.99.5;5.3.99.4", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0004796 thromboxane-A synthase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0030644 intracellular chloride ion homeostasis;GO:0045471 response to ethanol;GO:0045907 positive regulation of vasoconstriction;GO:0070542 response to fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P49430-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49684-1", "uniprot_id": "UR2R_RAT", "mass": 42707.0, "length": 386, "protein_name": "Urotensin-2 receptor", "gene_name": "Uts2r", "organism": "Rat", "refseq_name": "urotensin-2 receptor", "refseq_ac": "NP_065412", "gene_names_uniprotkb": "Uts2r; Gpr14; Senr", "gene_names_refseq": "Gpr14; Senr; UR-2-R; Uts2r", "protein_names_uniprotkb": "Urotensin-2 receptor; G protein-coupled receptor 14; G protein-coupled sensory epithelial neuropeptide-like receptor; SENR; UR-2-R; UR-II-R; Urotensin II receptor", "protein_names_refseq": "G-protein coupled receptor 14; G-protein coupled sensory epithelial neuropeptide-like receptor; UR-II-R; putative G protein-coupled receptor (SENR); urotensin II receptor; urotensin-2 receptor", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); endomyocardial fibrosis (Disease Ontology:DOID:12932); acute kidney failure (Disease Ontology:DOID:3021); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:57305); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12495432;14550283;24878476;25175740;25803040;27208703;34866110;7733947;8666380", "class_list": "", "function": "Expression of GPR14 was increased at mRNA and protein levels in brain from cerebral ischemia rats., [RefSeq, PubMed]; G protein-coupled receptor for the vasoactive neuropeptides urotensin-2 and urotensin-2B (PubMed:14550283). Upon ligand binding, activates intracellular signaling cascades via G protein coupling, primarily through Gq/11, leading to phospholipase C activation, increased intracellular calcium, and activation of protein kinase C (PKC). Through coupling to G(i)/G(o) alpha subunits, stimulates MAPK/ERK pathways and thereby contributes to regulation of vascular tone, cardiac contractility, and cell proliferation. Ligand binding also triggers a marked reduction in the biogenesis of autophagosomes by inhibiting the recruitment of ATG16L1 to pre-autophagosomal endocytic vesicles., [UniProtKB, PubMed, UniProtKB]; Key transmembrane domain 1 and 2 residues were identified in urotensin-II receptor (UT) that participate in the formation of the UT receptor binding pocket., [RefSeq, PubMed]; Results indicate that position 6 of urotensin-II normally occupied by phenylalanine would interact with Met(184) and/or Met(185) of the fourth transmembrane domain of the urotensin-II receptor (GPR14)., [RefSeq, PubMed]; Sterculia tragacantha Lindl Aqueous Leaf Extract Ameliorate Cardiomyopathy in Streptozotocin-induced Diabetic Rats via Urotensin II and FABP3 Expressions., [RefSeq, PubMed]; The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-kappaB pathways in LPS-stimulated Kupffer cells. Publication Status: Online-Only, [RefSeq, PubMed]; This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P48041", "ec_number_list": "", "go_molecular_function": "GO:0001604 urotensin II receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0030307 positive regulation of cell growth;GO:0045777 positive regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P49684-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49799-1", "uniprot_id": "RGS4_RAT", "mass": 23249.0, "length": 205, "protein_name": "Regulator of G protein signaling 4", "gene_name": "Rgs4", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 4", "refseq_ac": "NP_058910", "gene_names_uniprotkb": "Rgs4", "gene_names_refseq": "Rgs4", "protein_names_uniprotkb": "Regulator of G protein signaling 4; RGP4; RGS4", "protein_names_refseq": "RGP4; regulator of G-protein signaling 4", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypertension (Disease Ontology:DOID:10763); opioid abuse (Disease Ontology:DOID:11206); lesion of sciatic nerve (Disease Ontology:DOID:12528); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); bladder disease (Disease Ontology:DOID:365)", "pathway": " (rno:29480); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10702309;32779957;34450404;36793204;8548815;8602223;9108480;9353196", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein., [UniProtKB, UniProtKB, UniProtKB]; LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression., [RefSeq, PubMed]; Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in neurons., [RefSeq, PubMed]; The roles of ubiquitin-proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009898 cytoplasmic side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:1901379 regulation of potassium ion transmembrane transport;GO:1901380 negative regulation of potassium ion transmembrane transport;GO:0060160 negative regulation of dopamine receptor signaling pathway;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P49799-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49801-1", "uniprot_id": "RGS6_RAT", "mass": 7530.0, "length": 66, "protein_name": "Regulator of G protein signaling 6", "gene_name": "Rgs6", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rgs6", "gene_names_refseq": "", "protein_names_uniprotkb": "Regulator of G protein signaling 6; RGS6", "protein_names_refseq": "", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); alcohol dependence (Disease Ontology:DOID:0050741); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:54295)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;8548815", "class_list": "", "function": "Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0045666 positive regulation of neuron differentiation;GO:0009968 negative regulation of signal transduction;GO:0008277 regulation of G protein-coupled receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P49801-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49805-1", "uniprot_id": "RGS9_RAT", "mass": 77131.0, "length": 677, "protein_name": "Regulator of G protein signaling 9", "gene_name": "Rgs9", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 9", "refseq_ac": "NP_062097", "gene_names_uniprotkb": "Rgs9", "gene_names_refseq": "Rgs9", "protein_names_uniprotkb": "Regulator of G protein signaling 9; RGS9", "protein_names_refseq": "regulator of G-protein signaling 9", "tax_id": 10116, "disease": "bradyopsia 1 (Disease Ontology:DOID:0070363); Parkinsonism (Disease Ontology:DOID:0080855)", "pathway": " (rno:29481); (R-RNO-2514859); (R-RNO-418594); (R-RNO-6814122)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "12818179;14595021;21963945;22132185;8548815;9556034;9765512", "class_list": "", "function": "Data demonstrate a functional interaction between RGS9-2 and D2 receptor signaling and the behavioral actions of psychostimulants and suggest that psychostimulant induction of RGS9-2 represents a compensatory adaptation that diminishes drug responsiveness, [RefSeq, PubMed]; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Opiate-induced changes in RGS9 levels contribute to the behavioral and neural plasticity associated with chronic opiate administration, [RefSeq, PubMed]; RGS9 expression in striatum may involve in the abnormal involuntary movements induced by l-DOPA therapy, [RefSeq, PubMed]; These studies with humans, rats and mice implicate RGS9-2 as a factor in regulating body weight., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0007399 nervous system development;GO:0035556 intracellular signal transduction;GO:0001975 response to amphetamine;GO:0007212 G protein-coupled dopamine receptor signaling pathway;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P49805-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49806-1", "uniprot_id": "RGS10_RAT", "mass": 21176.0, "length": 181, "protein_name": "Regulator of G protein signaling 10", "gene_name": "Rgs10", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rgs10", "gene_names_refseq": "", "protein_names_uniprotkb": "Regulator of G protein signaling 10; RGS10", "protein_names_refseq": "", "tax_id": 10116, "disease": "opioid abuse (Disease Ontology:DOID:11206); glioblastoma (Disease Ontology:DOID:3068)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22673903;8548815", "class_list": "", "function": "Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V8Q0", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0043197 dendritic spine", "go_biological_process": "GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0043547 positive regulation of GTPase activity;GO:0001975 response to amphetamine;GO:0009968 negative regulation of signal transduction;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P49806-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49807-1", "uniprot_id": "RGS11_RAT", "mass": 7605.0, "length": 66, "protein_name": "Regulator of G protein signaling 11", "gene_name": "Rgs11", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rgs11", "gene_names_refseq": "", "protein_names_uniprotkb": "Regulator of G protein signaling 11; RGS11", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8548815", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0051286 cell tip;GO:0030425 dendrite;GO:0032991 protein-containing complex;GO:0044292 dendrite terminus", "go_biological_process": "GO:0009968 negative regulation of signal transduction;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50231-1", "uniprot_id": "CCL5_RAT", "mass": 10170.0, "length": 92, "protein_name": "C-C motif chemokine 5", "gene_name": "Ccl5", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ccl5; Scya5", "gene_names_refseq": "", "protein_names_uniprotkb": "C-C motif chemokine 5; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES", "protein_names_refseq": "", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); cardiac arrest (Disease Ontology:DOID:0060319); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); glucose intolerance (Disease Ontology:DOID:10603); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); allergic conjunctivitis (Disease Ontology:DOID:11204); sciatic neuropathy (Disease Ontology:DOID:11446); Chagas disease (Disease Ontology:DOID:12140); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); bronchopneumonia (Disease Ontology:DOID:12375); posterior uveitis (Disease Ontology:DOID:12574); uveitis (Disease Ontology:DOID:13141); pulmonary sarcoidosis (Disease Ontology:DOID:13406); peptic esophagitis (Disease Ontology:DOID:13976); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); orchitis (Disease Ontology:DOID:2518); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); antiphospholipid syndrome (Disease Ontology:DOID:2988); invasive ductal carcinoma (Disease Ontology:DOID:3008); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); cocaine abuse (Disease Ontology:DOID:809); extrinsic allergic alveolitis (Disease Ontology:DOID:841); lung disease (Disease Ontology:DOID:850); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-380108); (R-RNO-418594)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 54, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0004672 protein kinase activity;GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0097305 response to alcohol;GO:0071307 cellular response to vitamin K;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P50231-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51673-1", "uniprot_id": "RABP2_RAT", "mass": 15933.0, "length": 139, "protein_name": "Cellular retinoic acid-binding protein 2", "gene_name": "Crabp2", "organism": "Rat", "refseq_name": "cellular retinoic acid-binding protein 2", "refseq_ac": "NP_058940", "gene_names_uniprotkb": "Crabp2", "gene_names_refseq": "Crabp2", "protein_names_uniprotkb": "Cellular retinoic acid-binding protein 2; CRABP-II; Cellular retinoic acid-binding protein II", "protein_names_refseq": "CRABP-II; cellular lipid-binding protein; cellular retinoic acid-binding protein 2-like; cellular retinoic acid-binding protein 2; cellular retinoic acid-binding protein II", "tax_id": 10116, "disease": "", "pathway": " (rno:29563); (R-RNO-5362517)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7750498", "class_list": "", "function": "Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0019841 retinol binding;GO:0008289 lipid binding;GO:0016918 retinal binding;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006869 lipid transport;GO:0042573 retinoic acid metabolic process;GO:0015908 fatty acid transport;GO:0035115 embryonic forelimb morphogenesis;GO:0048672 positive regulation of collateral sprouting", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P51673-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51740-1", "uniprot_id": "PPBI2_RAT", "mass": 59797.0, "length": 551, "protein_name": "Intestinal-type alkaline phosphatase 2", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Intestinal-type alkaline phosphatase 2; 3.1.3.1; IAP-2; IAP-II; Intestinal alkaline phosphatase 2; Intestinal alkaline phosphatase II", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "1458592;1654110;1954251;7744844", "class_list": "", "function": "Alkaline phosphatase that can hydrolyze various phosphate compounds., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.2;3.1.3.1;3.1.3.48;3.9.1.1;3.1.3.5", "go_molecular_function": "GO:0004035 alkaline phosphatase activity;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51740-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52847-1", "uniprot_id": "ST1B1_RAT", "mass": 34835.0, "length": 299, "protein_name": "Sulfotransferase 1B1", "gene_name": "Sult1b1", "organism": "Rat", "refseq_name": "sulfotransferase 1B1", "refseq_ac": "NP_071958", "gene_names_uniprotkb": "Sult1b1; St1b1", "gene_names_refseq": "ST1B1; Sult1b1", "protein_names_uniprotkb": "Sulfotransferase 1B1; 2.8.2.1; DOPA/tyrosine sulfotransferase; ST1B1; Sulfotransferase family cytosolic 1B member 1", "protein_names_refseq": "dopa/tyrosine sulfotransferase; sulfotransferase 1B1; sulfotransferase family, cytosolic, 1B, member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:64305); (R-RNO-156584)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12773305;22447239;8033246;8530477;9443824", "class_list": "", "function": "Both fipronil and fipronil sulfone treatments induced a 2.5-fold increase in Ugt1a1 and Sult1b1 messenger RNA (mRNA) expressions. Erratum:[Toxicol Sci. 2012 Dec;130(2):444-5. Dosage error in article text], [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:12773305, PubMed:8530477). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.14;2.8.2.2;2.8.2.1;2.8.2.4", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051923 sulfation;GO:0030855 epithelial cell differentiation;GO:0006068 ethanol catabolic process;GO:0006805 xenobiotic metabolic process;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P52847-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53790-1", "uniprot_id": "SC5A1_RAT", "mass": 73066.0, "length": 665, "protein_name": "Sodium/glucose cotransporter 1", "gene_name": "Slc5a1", "organism": "Rat", "refseq_name": "sodium/glucose cotransporter 1", "refseq_ac": "NP_037165", "gene_names_uniprotkb": "Slc5a1; Sglt1", "gene_names_refseq": "SGLT1a; SGLT1; Slc5a1", "protein_names_uniprotkb": "Sodium/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 1; Solute carrier family 5 member 1", "protein_names_refseq": "Na(+)/glucose cotransporter 1; Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter); high affinity sodium-glucose cotransporter; sodium/glucose cotransporter 1; solute carrier family 5 (sodium/glucose cotransporter), member 1", "tax_id": 10116, "disease": "glucose-galactose malabsorption (Disease Ontology:DOID:0070563)", "pathway": " (rno:25552); (R-RNO-189200); (R-RNO-8981373)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "26902517;26920054;31828140;33608832;8163506;9214758", "class_list": "", "function": "Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity). Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (By similarity). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (By similarity). Acts as a water channel enabling passive water transport in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity comparable to aquaporins and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine., [UniProtKB, UniProtKB, UniProtKB]; Intermittent high glucose induces pyroptosis of rat H9C2 cardiomyocytes via sodium-glucose cotransporter 1., [RefSeq, PubMed]; Present study indicated that inhibition of SGLT1 by phlorizin abrogated the beneficial effect of ischemic-preconditioning and for the first time, provides evidence that SGLT1 plays a crucial role in ischemic preconditioning-induced cardioprotection., [RefSeq, PubMed]; SGLT1 activity in lung alveolar cells of diabetic rats modulates airway surface liquid glucose concentration and bacterial proliferation. Publication Status: Online-Only, [RefSeq, PubMed]; This study also aims to determine the active ingredients of H. sabdariffa (Hib) that interact with sodium-glucose cotransporter-1 (SGLT-1) so that it can increase GLP-1 secretion in the ileum and interact with GLP-1 receptors (GLP-1R) in the pancreas. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97787", "ec_number_list": "", "go_molecular_function": "GO:0005412 D-glucose:sodium symporter activity;GO:0005372 water transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0015371 galactose:sodium symporter activity;GO:0015151 alpha-glucoside transmembrane transporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0035623 renal D-glucose absorption;GO:1904659 D-glucose transmembrane transport;GO:0001951 intestinal D-glucose absorption;GO:0050892 intestinal absorption;GO:0001656 metanephros development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53790-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56573-1", "uniprot_id": "UH05_RAT", "mass": 1269.0, "length": 10, "protein_name": "Unknown protein from spot P5 of 2D-PAGE of heart tissue", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Unknown protein from spot P5 of 2D-PAGE of heart tissue", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P56573-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57769-1", "uniprot_id": "SNX16_RAT", "mass": 38848.0, "length": 344, "protein_name": "Sorting nexin-16", "gene_name": "Snx16", "organism": "Rat", "refseq_name": "sorting nexin-16", "refseq_ac": "NP_071625", "gene_names_uniprotkb": "Snx16", "gene_names_refseq": "Snx16", "protein_names_uniprotkb": "Sorting nexin-16", "protein_names_refseq": "sorting nexin-16", "tax_id": 10116, "disease": "polycythemia due to hypoxia (Disease Ontology:DOID:2835)", "pathway": " (rno:64088)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12813048;15292396;22673903", "class_list": "", "function": "May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling., [UniProtKB, PubMed, UniProtKB, UniProtKB]; SNX16 directs the sorting of EGFR to the endosomal compartment and thus regulates EGF-induced cell signaling., [RefSeq, PubMed]; SNX16 is a sorting nexin that may function in the trafficking of proteins between the early and late endosomal compartments, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7R2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005764 lysosome;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0005770 late endosome", "go_biological_process": "GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport;GO:0006622 protein targeting to lysosome;GO:0001881 receptor recycling;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P57769-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59241-1", "uniprot_id": "AURKA_RAT", "mass": 44874.0, "length": 397, "protein_name": "Aurora kinase A", "gene_name": "Aurka", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Aurka; Aik; Airk1; Ark1; Aura; Ayk1; Btak; Iak1; Stk15; Stk6", "gene_names_refseq": "", "protein_names_uniprotkb": "Aurora kinase A; 2.7.11.1; ARK-1; Aurora 2; Aurora-related kinase 1; Aurora/IPL1-related kinase 1; Ipl1- and aurora-related kinase 1; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Ayk1; Serine/threonine-protein kinase aurora-A; ratAurA", "protein_names_refseq": "", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); brain cancer (Disease Ontology:DOID:1319); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); invasive ductal carcinoma (Disease Ontology:DOID:3008); uterine cancer (Disease Ontology:DOID:363); renal cell carcinoma (Disease Ontology:DOID:4450); prostate carcinoma in situ (Disease Ontology:DOID:8634); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-174178); (R-RNO-2565942); (R-RNO-6804114); (R-RNO-6804756); (R-RNO-8854050); (R-RNO-8854518); (R-RNO-8854521)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "12124350;19812038", "class_list": "", "function": "Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (By similarity). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (By similarity). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for initial activation of CDK1 at centrosomes (By similarity). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (By similarity). Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization (By similarity). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizating p53/TP53 (By similarity). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.3.2.32;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.3.2.23;2.7.11.12;2.7.11.26;2.7.11.34;2.3.2.24;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;3.4.25.1;2.7.11.31;3.1.3.16;3.6.5.-;3.6.4.10;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0014069 postsynaptic density", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006468 protein phosphorylation;GO:0010629 negative regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0045931 positive regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P59241-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59996-1", "uniprot_id": "PCSK9_RAT", "mass": 74709.0, "length": 691, "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "Pcsk9", "organism": "Rat", "refseq_name": "proprotein convertase subtilisin/kexin type 9 precursor", "refseq_ac": "NP_954862", "gene_names_uniprotkb": "Pcsk9; Narc1", "gene_names_refseq": "NARC-1; Narc1; PC9; Pcsk9", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 9; 3.4.21.-; NARC-1; Neural apoptosis-regulated convertase 1; PC9; Proprotein convertase 9; Subtilisin/kexin-like protease PC9", "protein_names_refseq": "neural apoptosis-regulated convertase 1; proprotein convertase 9; proprotein convertase PC9; proprotein convertase subtilisin/kexin type 9 precursor; subtilisin/kexin-like protease PC9", "tax_id": 10116, "disease": "familial hypercholesterolemia (Disease Ontology:DOID:13810); hypobetalipoproteinemia (Disease Ontology:DOID:1390)", "pathway": " (rno:298296); (R-RNO-381426); (R-RNO-8866427); (R-RNO-8957275); (R-RNO-8964038)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12552133;14622975;35460665;35742954;36342620;37844755;38154546", "class_list": "", "function": "Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity)., [UniProtKB]; High-salt diet induces dyslipidemia through the SREBP2/PCSK9 pathway in dahl salt-sensitive rats., [RefSeq, PubMed]; NARC-1 is a proteinase K-like subtilase with a role in the differentiation of cortical neurons., [RefSeq, PubMed]; Our functional characterization of Narc 1 reinforces the inference drawn that this enzyme is most closely related to representatives of the proteinase K family, but it is also sufficiently different to warrant its classification in a separate sub-family., [RefSeq, PubMed]; PCSK9 Knockdown Can Improve Myocardial Ischemia/Reperfusion Injury by Inhibiting Autophagy., [RefSeq, PubMed]; PCSK9 inhibition protects against myocardial ischemia-reperfusion injury via suppressing autophagy., [RefSeq, PubMed]; PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction., [RefSeq, PubMed]; Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Deletion but Not Inhibition of Extracellular PCSK9 Reduces Infarct Sizes Ex Vivo but Not In Vivo. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5I6U6", "ec_number_list": "5.3.4.1;3.1.1.4;3.1.1.3;1.11.1.27;1.16.3.1;1.11.1.9;1.16.3.4;3.4.21.69;3.4.21.-;3.4.24.81;2.4.1.145;3.6.4.-;3.2.1.51;1.8.3.2;3.4.21.112", "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0019871 sodium channel inhibitor activity;GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0034185 apolipoprotein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001889 liver development;GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process;GO:0016485 protein processing;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P59996-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61227-1", "uniprot_id": "RAP2B_RAT", "mass": 20504.0, "length": 183, "protein_name": "Ras-related protein Rap-2b", "gene_name": "Rap2b", "organism": "Rat", "refseq_name": "ras-related protein Rap-2b", "refseq_ac": "NP_596901", "gene_names_uniprotkb": "Rap2b", "gene_names_refseq": "Rap2b", "protein_names_uniprotkb": "Ras-related protein Rap-2b; 3.6.5.2", "protein_names_refseq": "ras-related protein Rap-2b", "tax_id": 10116, "disease": "", "pathway": " (rno:170923); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21048137", "class_list": "", "function": "MINK interaction with Rap2 plays a critical role in maintaining the morphological integrity of dendrites and synaptic transmission., [RefSeq, PubMed]; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17964;Q96EG5;Q9CXG0", "ec_number_list": "3.6.5.2;3.1.3.48;7.6.2.1;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.3.1.51;2.7.11.1;3.6.5.5;3.6.1.5;1.14.14.18;3.4.21.73;1.1.1.-;3.1.4.4;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;3.6.1.-;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;1.14.19.17;5.2.1.-;3.2.2.6;3.6.5.4;3.2.1.20;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0030336 negative regulation of cell migration;GO:0030168 platelet activation;GO:0070527 platelet aggregation;GO:0031954 positive regulation of protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61227-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61265-1", "uniprot_id": "STX1B_RAT", "mass": 33245.0, "length": 288, "protein_name": "Syntaxin-1B", "gene_name": "Stx1b", "organism": "Rat", "refseq_name": "syntaxin-1B", "refseq_ac": "NP_036832", "gene_names_uniprotkb": "Stx1b; Stx1b2", "gene_names_refseq": "Stx1b2; Stx1b; Stx2", "protein_names_uniprotkb": "Syntaxin-1B; P35B; Syntaxin-1B2", "protein_names_refseq": "P35B; Syntaxin 2; syntaxin 1B2; syntaxin-1B", "tax_id": 10116, "disease": "generalized epilepsy with febrile seizures plus 9 (Disease Ontology:DOID:0111301); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:24923); (R-RNO-5682910)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12692561;1321498;22673903;7690687;7737992;7901002", "class_list": "", "function": "Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm., [UniProtKB, UniProtKB]; Potentially involved in docking of synaptic vesicles at presynaptic active zones (PubMed:7901002). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)., [UniProtKB, PubMed]; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P32853", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:2000463 positive regulation of excitatory postsynaptic potential;GO:0010977 negative regulation of neuron projection development;GO:0016192 vesicle-mediated transport;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P61265-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61354-1", "uniprot_id": "RL27_RAT", "mass": 15798.0, "length": 136, "protein_name": "Large ribosomal subunit protein eL27", "gene_name": "Rpl27", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL27", "refseq_ac": "NP_071959", "gene_names_uniprotkb": "Rpl27", "gene_names_refseq": "Rpl27", "protein_names_uniprotkb": "Large ribosomal subunit protein eL27; 60S ribosomal protein L27", "protein_names_refseq": "60S ribosomal protein L27; large ribosomal subunit protein eL27", "tax_id": 10116, "disease": "Diamond-Blackfan anemia 16 (Disease Ontology:DOID:0111893)", "pathway": " (rno:64306); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "2833393", "class_list": "", "function": "Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08526;Q5BJ97", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0005840 ribosome", "go_biological_process": "GO:0006364 rRNA processing;GO:1904044 response to aldosterone;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61354-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62142-1", "uniprot_id": "PP1B_RAT", "mass": 37187.0, "length": 327, "protein_name": "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "gene_name": "Ppp1cb", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase PP1-beta catalytic subunit", "refseq_ac": "NP_037197", "gene_names_uniprotkb": "Ppp1cb", "gene_names_refseq": "PP1B; PP1beta; Ppp1cb", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP1-beta catalytic subunit; 3.1.3.16; 3.1.3.53; PP-1B", "protein_names_refseq": "PP-1B; protein phosphatase 1, catalytic subunit, beta isozyme; protein phosphatase-1a; serine/threonine-protein phosphatase PP1-beta catalytic subunit", "tax_id": 10116, "disease": "Noonan syndrome-like disorder with loose anagen hair 2 (Disease Ontology:DOID:0080693); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:25594); (R-RNO-2565942); (R-RNO-5625740); (R-RNO-5627123); (R-RNO-5673000); (R-RNO-9770562)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "2177460;26702053;38843836;7720853;7751917", "class_list": "", "function": "Data suggest FSH and IGF1 (insulin-like growth factor-1) PI3K signaling pathways in granulosa cells converge at IRS1 (insulin receptor substrate 1), requiring PKA (cyclic AMP-dependent protein kinase) and PP1 (protein phosphatase 1) to regulate IRS1., [RefSeq, PubMed]; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P37140", "ec_number_list": "3.1.3.16;3.6.4.13;3.1.3.48;2.7.7.19;2.7.11.1;3.1.3.53;3.1.3.52;2.7.7.6;2.3.2.27;3.1.3.67;3.1.3.-;3.1.3.27;2.7.11.22;3.6.5.2;2.7.7.52;2.7.1.78;2.7.11.21;3.1.3.74", "go_molecular_function": "GO:0050115 myosin-light-chain-phosphatase activity;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0005981 regulation of glycogen catabolic process;GO:0030155 regulation of cell adhesion;GO:0051301 cell division;GO:0005977 glycogen metabolic process;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62142-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62268-1", "uniprot_id": "RS23_RAT", "mass": 15808.0, "length": 143, "protein_name": "Small ribosomal subunit protein uS12", "gene_name": "Rps23", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS12", "refseq_ac": "NP_511172", "gene_names_uniprotkb": "Rps23", "gene_names_refseq": "Rps23", "protein_names_uniprotkb": "Small ribosomal subunit protein uS12; 40S ribosomal protein S23", "protein_names_refseq": "40S ribosomal protein S23; small ribosomal subunit protein uS12", "tax_id": 10116, "disease": "brachycephaly, trichomegaly, and developmental delay (Disease Ontology:DOID:0070415)", "pathway": " (rno:124323); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-9629569); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "38843836;8037726", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P39028", "ec_number_list": "", "go_molecular_function": "GO:0045182 translation regulator activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0005840 ribosome;GO:0022626 cytosolic ribosome;GO:0015935 small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0034063 stress granule assembly;GO:1990145 maintenance of translational fidelity;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62268-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62271-1", "uniprot_id": "RS18_RAT", "mass": 17719.0, "length": 152, "protein_name": "Small ribosomal subunit protein uS13", "gene_name": "Rps18", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS13", "refseq_ac": "NP_998722", "gene_names_uniprotkb": "Rps18", "gene_names_refseq": "Ke3; Rps18", "protein_names_uniprotkb": "Small ribosomal subunit protein uS13; 40S ribosomal protein S18", "protein_names_refseq": "40S ribosomal protein S18; small ribosomal subunit protein uS13", "tax_id": 10116, "disease": "", "pathway": " (rno:294282); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 3, "publication_id_list": "15060004;1872840;23736358", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]; Our study demonstrates that gene expression levels of reference genes commonly used in obesity-related studies, such as ACTB or RPS18, are altered by changes in acute or chronic energy status., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN05;P25232", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62271-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62489-1", "uniprot_id": "RPB7_RAT", "mass": 19294.0, "length": 172, "protein_name": "DNA-directed RNA polymerase II subunit RPB7", "gene_name": "Polr2g", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerase II subunit RPB7", "refseq_ac": "NP_446400", "gene_names_uniprotkb": "Polr2g", "gene_names_refseq": "Polr2g; Rpb7", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB7; DNA-directed RNA polymerase II subunit G; RNA polymerase II subunit B7", "protein_names_refseq": "DNA-directed RNA polymerase II subunit G; DNA-directed RNA polymerase II subunit RPB7; RNA polymerase II subunit B7; polymerase (RNA) II (DNA directed) polypeptide G; polymerase (RNA) II subunit G", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:117017); (R-RNO-112382); (R-RNO-113418); (R-RNO-5578749); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-6803529); (R-RNO-6807505); (R-RNO-72086); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075); (R-RNO-9018519); (R-RNO-9770562)", "pathway_count": 23, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2G/RPB7 is part of a subcomplex with POLR2D/RPB4 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P52433", "ec_number_list": "", "go_molecular_function": "GO:0003727 single-stranded RNA binding;GO:0003697 single-stranded DNA binding;GO:0031369 translation initiation factor binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000932 P-body;GO:0005665 RNA polymerase II, core complex;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P62489-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62501-1", "uniprot_id": "T22D1_RAT", "mass": 106786.0, "length": 1050, "protein_name": "TSC22 domain family protein 1", "gene_name": "Tsc22d1", "organism": "Rat", "refseq_name": "TSC22 domain family protein 1 isoform 1", "refseq_ac": "NP_001103382", "gene_names_uniprotkb": "Tsc22d1; Tgfb1i4; Tsc22", "gene_names_refseq": "TS22A; TSC-22; Tgfb1i4; Tsc22d1", "protein_names_uniprotkb": "TSC22 domain family protein 1; Regulatory protein TSC-22; TGFB-stimulated clone 22 homolog; Transforming growth factor beta-1-induced transcript 4 protein", "protein_names_refseq": "TGFB-stimulated clone 22 homolog; TSC22 domain family protein 1 isoform 1; TSC22 domain family protein 1; Transforming growth factor beta stimulated clone 22; regulatory protein TSC-22; transforming growth factor beta 1 induced transcript 4; transforming growth factor beta-1-induced transcript 4 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:498545)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21791611;8161377;9022669", "class_list": "", "function": "May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells., [UniProtKB, UniProtKB]; Positively regulates cell death in response to TGFB3 during mammary gland involution., [UniProtKB, UniProtKB]; TSC-22 can promote the differentiation of cardiac myofibroblasts by increasing expression of the fibrotic genes for alpha-smooth muscle actin, PAI-1, fibronectin, and collagen I., [RefSeq, PubMed]; Transcriptional repressor (By similarity). Acts on the C-type natriuretic peptide (CNP) promoter (By similarity). Acts to promote CASP3-mediated apoptosis (By similarity). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (By similarity). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (By similarity). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0JPR0;D3Z8M8;Q00992", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62501-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62718-1", "uniprot_id": "RL18A_RAT", "mass": 20732.0, "length": 176, "protein_name": "Large ribosomal subunit protein eL20", "gene_name": "Rpl18al1; Rpl18a", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL20", "refseq_ac": "NP_997675", "gene_names_uniprotkb": "Rpl18al1; Rpl18a; AABR07001902.1; Rpl18a", "gene_names_refseq": "Rpl18a", "protein_names_uniprotkb": "Large ribosomal subunit protein eL20; 60S ribosomal protein L18a", "protein_names_refseq": "60S ribosomal protein L18a; large ribosomal subunit protein eL20", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:290641); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "2541017;7654221", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11249", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0005840 ribosome;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0097327 response to antineoplastic agent;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62718-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62824-1", "uniprot_id": "RAB3C_RAT", "mass": 25872.0, "length": 227, "protein_name": "Ras-related protein Rab-3C", "gene_name": "Rab3c", "organism": "Rat", "refseq_name": "ras-related protein Rab-3C isoform 1", "refseq_ac": "NP_598220", "gene_names_uniprotkb": "Rab3c", "gene_names_refseq": "Rab3c", "protein_names_uniprotkb": "Ras-related protein Rab-3C; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-3C isoform 1; ras-related protein Rab-3C", "tax_id": 10116, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:171058); (R-RNO-8873719)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "8841986;8885988;9252191", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62858;Q62974;Q63482;Q9CXQ1", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;2.5.1.60;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0030742 GTP-dependent protein binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0031982 vesicle;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0019882 antigen processing and presentation;GO:0017157 regulation of exocytosis;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62824-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62828-1", "uniprot_id": "RAN_RAT", "mass": 24423.0, "length": 216, "protein_name": "GTP-binding nuclear protein Ran", "gene_name": "Ran", "organism": "Rat", "refseq_name": "GTP-binding nuclear protein Ran", "refseq_ac": "NP_445891", "gene_names_uniprotkb": "Ran", "gene_names_refseq": "Ran", "protein_names_uniprotkb": "GTP-binding nuclear protein Ran; 3.6.5.-; GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein", "protein_names_refseq": "GTP-binding nuclear protein Ran; GTPase Ran; ras-like protein TC4; ras-related nuclear protein", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:84509); (R-RNO-1655829); (R-RNO-5578749); (R-RNO-9615933)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "15240697;34502162;38843836", "class_list": "", "function": "GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17080;P28746;P28747;Q9CSP3;Q9CWI7;Q9CZA2;Q9UDJ5;Q9UEU9", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4;3.1.26.n2", "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:1905172 RISC complex binding;GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0000055 ribosomal large subunit export from nucleus;GO:1902570 protein localization to nucleolus;GO:0061015 snRNA import into nucleus;GO:0006913 nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62828-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62832-1", "uniprot_id": "RL23_RAT", "mass": 14865.0, "length": 140, "protein_name": "Large ribosomal subunit protein uL14", "gene_name": "Rpl23", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL14", "refseq_ac": "NP_001007600", "gene_names_uniprotkb": "Rpl23; LOC134480573", "gene_names_refseq": "RL23a; Rpl23", "protein_names_uniprotkb": "Large ribosomal subunit protein uL14; 60S ribosomal protein L23", "protein_names_refseq": "60S ribosomal protein L23; large ribosomal subunit protein uL14", "tax_id": 10116, "disease": "", "pathway": " (rno:29282); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "1840488;38843836", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P23131;P24048;Q29246", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0001223 transcription coactivator binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0050821 protein stabilization;GO:1901798 positive regulation of signal transduction by p53 class mediator;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62832-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62836-1", "uniprot_id": "RAP1A_RAT", "mass": 20987.0, "length": 184, "protein_name": "Ras-related protein Rap-1A", "gene_name": "Rap1a", "organism": "Rat", "refseq_name": "ras-related protein Rap-1A", "refseq_ac": "NP_001005765", "gene_names_uniprotkb": "Rap1a; Krev1", "gene_names_refseq": "RAP-1A; Rap1a; rap 1A", "protein_names_uniprotkb": "Ras-related protein Rap-1A; 3.6.5.2; Ras-related protein Krev-1", "protein_names_refseq": "RAS-related protein 1a; ras-related protein Krev-1; ras-related protein Rap-1A", "tax_id": 10116, "disease": "", "pathway": " (rno:295347); (R-RNO-170968); (R-RNO-170984); (R-RNO-354192); (R-RNO-354194); (R-RNO-372708); (R-RNO-381676); (R-RNO-392517); (R-RNO-5674135); (R-RNO-6798695); (R-RNO-8875555)", "pathway_count": 11, "publication_count": 8, "publication_id_list": "11179219;17724123;25533468;2642744;26854595;30520098;31173168;32452765", "class_list": "", "function": "Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (By similarity). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions., [UniProtKB, PubMed, UniProtKB]; Data suggest activation of EPAC1/2 (exchange proteins activated by cAMP) and Rap1 (RAS-related GTP-binding protein 1) in hepatic stellate cells down-regulates proliferation and synthesis of a-smooth muscle actin/collagen I/collagen II in an in vitro model of alcoholic cirrhosis (AC); in AC, expression of EPAC1 is down-regulated but expression of EPAC2 is up-regulated; EPAC1 activation increases GTP-bound (activated) Rap1., [RefSeq, PubMed]; Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases., [RefSeq, PubMed]; Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics. Publication Status: Online-Only, [RefSeq, PubMed]; That RAP1A was a direct target gene of miR-202 in the PC12 cell. RAP1A expression was upregulated in the spinal dorsal horn of bilateral sciatic nerve chronic constriction injury (bCCI)rat., [RefSeq, PubMed]; These findings suggest that TGFbeta1 regulates Rap1, resulting in the suppression of RhoA, activation of and formation of Factin during the migration of hepatic stellate cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10113", "ec_number_list": "3.6.5.2;3.1.3.48;7.6.2.1;2.7.11.1;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.3.1.51;3.6.5.5;2.7.10.2;3.6.1.5;2.7.11.24;1.14.14.18;3.4.21.73;2.7.10.4;2.7.10.1;2.7.12.2;3.6.4.-;1.1.1.-;3.1.4.4;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;3.6.1.-;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;1.14.19.17;5.2.1.-;3.2.2.6;3.6.5.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P62836-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62890-1", "uniprot_id": "RL30_RAT", "mass": 12784.0, "length": 115, "protein_name": "Large ribosomal subunit protein eL30", "gene_name": "Rpl30", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL30", "refseq_ac": "NP_073190", "gene_names_uniprotkb": "Rpl30", "gene_names_refseq": "Rpl30", "protein_names_uniprotkb": "Large ribosomal subunit protein eL30; 60S ribosomal protein L30", "protein_names_refseq": "60S ribosomal protein L30; large ribosomal subunit protein eL30", "tax_id": 10116, "disease": "", "pathway": " (rno:64640); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "15240697;23777426;3840111", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]; L30 and SBP2 bind to overlapping but non-identical sites on the SECIS. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04645", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62890-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62893-1", "uniprot_id": "RL39_RAT", "mass": 6407.0, "length": 51, "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "Rpl39", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL39", "refseq_ac": "NP_037007", "gene_names_uniprotkb": "Rpl39; LOC103690821; LOC103694404; Rpl31-ps12; Rpl31l13; Rpl39-ps10; Rpl39-ps11; Rpl39-ps12; Rpl39-ps13; Rpl39-ps14", "gene_names_refseq": "Rpl39", "protein_names_uniprotkb": "Large ribosomal subunit protein eL39; 60S ribosomal protein L39", "protein_names_refseq": "60S ribosomal protein L39; large ribosomal subunit protein eL39", "tax_id": 10116, "disease": "", "pathway": " (rno:25347); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "6706949;7654221", "class_list": "", "function": "RNA-binding component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02404;P39025;Q9BYF2", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0002227 innate immune response in mucosa;GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62893-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62909-1", "uniprot_id": "RS3_RAT", "mass": 26674.0, "length": 243, "protein_name": "Small ribosomal subunit protein uS3", "gene_name": "Rps3l1; Rps3", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS3", "refseq_ac": "NP_001009239", "gene_names_uniprotkb": "Rps3l1; Rps3; AABR07052430.1; RGD1560831; Rps3l1", "gene_names_refseq": "Rps3", "protein_names_uniprotkb": "Small ribosomal subunit protein uS3; 4.2.99.18; 40S ribosomal protein S3", "protein_names_refseq": "40S ribosomal protein S3; small ribosomal subunit protein uS3", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (rno:140654); (rno:499803); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 6, "publication_id_list": "18683930;2275563;34502162;37087770;38843836;7775413", "class_list": "", "function": "Component of the small ribosomal subunit (By similarity). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). Stimulates the N-glycosylase activity of the base excision protein OGG1 (By similarity). Enhances the uracil excision activity of UNG1 (By similarity). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (By similarity). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (By similarity). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (By similarity). Represses its own translation by binding to its cognate mRNA (By similarity). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (By similarity). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (By similarity). Involved in induction of apoptosis through its role in activation of CASP8 (By similarity). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (By similarity). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (By similarity)., [UniProtKB, UniProtKB, PubMed]; RNA binding protein RPS3 mediates microglial polarization by activating NLRP3 inflammasome via SIRT1 in ischemic stroke., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17073;P47933", "ec_number_list": "2.7.11.1;3.6.5.3;1.14.11.51;4.2.99.18;1.14.11.33;2.3.2.24;2.3.2.23;2.3.2.27;3.2.2.-;3.1.-.-;3.6.1.62;5.6.2.4;3.6.4.13;2.7.7.7;4.2.99.-;3.1.3.16;2.7.11.22;2.7.11.26;3.6.5.-;3.6.5.4", "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0007059 chromosome segregation;GO:0010628 positive regulation of gene expression;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P62909-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62914-1", "uniprot_id": "RL11_RAT", "mass": 20252.0, "length": 178, "protein_name": "Large ribosomal subunit protein uL5", "gene_name": "Rpl11", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL5 isoform X1", "refseq_ac": "XP_006239286", "gene_names_uniprotkb": "Rpl11", "gene_names_refseq": "Rpl11", "protein_names_uniprotkb": "Large ribosomal subunit protein uL5; 60S ribosomal protein L11", "protein_names_refseq": "large ribosomal subunit protein uL5 isoform X1", "tax_id": 10116, "disease": "Diamond-Blackfan anemia 7 (Disease Ontology:DOID:0111878); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 10, "publication_count": 2, "publication_id_list": "1599472;38843836", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Promotes nucleolar location of PML., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25121;P39026;Q9Y674", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0031625 ubiquitin protein ligase binding;GO:0042975 peroxisome proliferator activated receptor binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0006605 protein targeting;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0006412 translation;GO:0034504 protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62914-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62948-1", "uniprot_id": "RS32_RAT", "mass": 3456.0, "length": 25, "protein_name": "Small ribosomal subunit protein eS32", "gene_name": "Rpl41", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS32", "refseq_ac": "NP_620783", "gene_names_uniprotkb": "Rpl41", "gene_names_refseq": "Rpl41", "protein_names_uniprotkb": "Small ribosomal subunit protein eS32; 60S ribosomal protein L41; Large ribosomal subunit protein eL41", "protein_names_refseq": "60S ribosomal protein L41; large ribosomal subunit protein eL41; small ribosomal subunit protein eS32", "tax_id": 10116, "disease": "", "pathway": " (rno:124440)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7575549", "class_list": "", "function": "Component of the small ribosomal subunit (Probable) (Ref.2). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (By similarity). Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P28751", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0048027 mRNA 5'-UTR binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62948-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63164-1", "uniprot_id": "RSMN_RAT", "mass": 24614.0, "length": 240, "protein_name": "Small nuclear ribonucleoprotein-associated protein N", "gene_name": "Snrpn", "organism": "Rat", "refseq_name": "small nuclear ribonucleoprotein-associated protein N", "refseq_ac": "NP_112379", "gene_names_uniprotkb": "Snrpn; Smn; Snurf", "gene_names_refseq": "FE 294 psi; FE 294; FE294 psi; FE294; Snrpn", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein-associated protein N; Sm protein D; Sm protein N; Sm-D; Sm-N; SmN; snRNP-N", "protein_names_refseq": "FE294 gene for snRNP-associated polypeptide N; FE294 psi pseudogene; sm protein D; sm protein N; sm-D; sm-N; smN; small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51; small nuclear ribonucleoprotein N; small nuclear ribonucleoprotein-associated protein N; snRNP-N", "tax_id": 10116, "disease": "Prader-Willi syndrome (Disease Ontology:DOID:11983); Angelman syndrome (Disease Ontology:DOID:1932); tauopathy (Disease Ontology:DOID:680)", "pathway": " (rno:81781); (R-RNO-72163); (R-RNO-9770562); (R-RNO-9943411)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "1981744;2522186;2526016;2532363;27071665;27184949", "class_list": "", "function": "May be involved in tissue-specific alternative RNA processing events., [UniProtKB]; Sm51 plays an important role in regulating osteogenic differentiation of mesenchymal stem cells through increasing Runx2 expression, [RefSeq, PubMed]; Varicocele does not alter the methylation profiles of H19 and Snrpn gene, but exerts depressant-like effect on the adult rat offspring., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P14648;P17135", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0070990 snRNP binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0005687 U4 snRNP", "go_biological_process": "GO:0009725 response to hormone;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P63164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63174-1", "uniprot_id": "RL38_RAT", "mass": 8218.0, "length": 70, "protein_name": "Large ribosomal subunit protein eL38", "gene_name": "Rpl38", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL38", "refseq_ac": "NP_001071060", "gene_names_uniprotkb": "Rpl38", "gene_names_refseq": "Rpl38", "protein_names_uniprotkb": "Large ribosomal subunit protein eL38; 60S ribosomal protein L38", "protein_names_refseq": "60S ribosomal protein L38; large ribosomal subunit protein eL38", "tax_id": 10116, "disease": "otitis media (Disease Ontology:DOID:10754)", "pathway": " (rno:689284); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "1840484", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P23411;Q3T1G5", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:0006417 regulation of translation;GO:0001501 skeletal system development;GO:0007605 sensory perception of sound;GO:0001503 ossification;GO:0042474 middle ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63174-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70550-1", "uniprot_id": "RAB8B_RAT", "mass": 23603.0, "length": 207, "protein_name": "Ras-related protein Rab-8B", "gene_name": "Rab8b", "organism": "Rat", "refseq_name": "ras-related protein Rab-8B", "refseq_ac": "NP_695229", "gene_names_uniprotkb": "Rab8b", "gene_names_refseq": "Rab8b", "protein_names_uniprotkb": "Ras-related protein Rab-8B; 3.6.5.2", "protein_names_refseq": "GTPase Rab8b; ras-related protein Rab-8B", "tax_id": 10116, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167)", "pathway": " (rno:266688); (R-RNO-8854214); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11278749;12639940;29393594;8799816", "class_list": "", "function": "Rab8B participates in adherens junction dynamics in the testis., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (By similarity). May participate in cell junction dynamics in Sertoli cells (PubMed:12639940). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;2.5.1.60;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0030911 TPR domain binding;GO:0003924 GTPase activity;GO:0005102 signaling receptor binding;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005768 endosome;GO:0005778 peroxisomal membrane;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051461 positive regulation of corticotropin secretion;GO:0006887 exocytosis;GO:0032456 endocytic recycling;GO:0045046 protein import into peroxisome membrane;GO:0019882 antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70550-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70711-1", "uniprot_id": "U2D2B_RAT", "mass": 16659.0, "length": 147, "protein_name": "Ubiquitin-conjugating enzyme E2 D2B", "gene_name": "Ube2d2b", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 D2B", "refseq_ac": "NP_112263", "gene_names_uniprotkb": "Ube2d2b; Ube2d2", "gene_names_refseq": "RGD69425; Ube2d2b; Ube2d2; Ube2d4", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 D2B; 2.3.2.23; E2 ubiquitin-conjugating enzyme D2B; Ubiquitin carrier protein D2B; Ubiquitin-conjugating enzyme E2(17)KB 2B; Ubiquitin-conjugating enzyme E2-17 kDa 2B; Ubiquitin-protein ligase D2B", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme D2B; E2(17)KB 2B; ubiquitin carrier protein D2B; ubiquitin-conjugating enzyme E2 D2B; ubiquitin-conjugating enzyme E2(17)KB 2B; ubiquitin-conjugating enzyme E2-17 kDa 2B; ubiquitin-conjugating enzyme E2D 2; ubiquitin-conjugating enzyme E2D 4 (putative); ubiquitin-protein ligase D2B", "tax_id": 10116, "disease": "", "pathway": " (rno:79435)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8754804", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection Plays a role in early maturation of the testis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0070979 protein K11-linked ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0071276 cellular response to cadmium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P70711-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81728-1", "uniprot_id": "SPRT_RAT", "mass": 5338.0, "length": 50, "protein_name": "Sproutin", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Sproutin; TA20", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10424680", "class_list": "", "function": "Neurite outgrowth factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P81728-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83121-1", "uniprot_id": "UP3_RAT", "mass": 11100.0, "length": 101, "protein_name": "Urinary protein 3", "gene_name": "", "organism": "Rat", "refseq_name": "urinary protein 3 precursor", "refseq_ac": "NP_001420355", "gene_names_uniprotkb": "", "gene_names_refseq": "LOC134480016; Rup-3", "protein_names_uniprotkb": "Urinary protein 3; UP-3; rUP-3", "protein_names_refseq": "urinary protein 3 precursor", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "11565799;11840564", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001848 complement binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0001971 negative regulation of activation of membrane attack complex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P83121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84100-1", "uniprot_id": "RL19_RAT", "mass": 23466.0, "length": 196, "protein_name": "Large ribosomal subunit protein eL19", "gene_name": "Rpl19", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL19", "refseq_ac": "NP_112365", "gene_names_uniprotkb": "Rpl19", "gene_names_refseq": "Rpl19", "protein_names_uniprotkb": "Large ribosomal subunit protein eL19; 60S ribosomal protein L19", "protein_names_refseq": "60S ribosomal protein L19-like; 60S ribosomal protein L19; large ribosomal subunit protein eL19", "tax_id": 10116, "disease": "", "pathway": " (rno:81767); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "12042320;3542997;7789970", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P14118;P22908", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:1990932 5.8S rRNA binding;GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0097421 liver regeneration;GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P84100-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84107-1", "uniprot_id": "RHG_RAT", "mass": 949.0, "length": 9, "protein_name": "Rho-GTPase-activating protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho-GTPase-activating protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May keep Rho-GTPase in a GDP-bound form., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P84107-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84586-1", "uniprot_id": "RMXRL_RAT", "mass": 42204.0, "length": 388, "protein_name": "RNA-binding motif protein, X chromosome retrogene-like", "gene_name": "Rbmxl1; Rbmxrtl; Rbmx", "organism": "Rat", "refseq_name": "RNA-binding motif protein, X chromosome retrogene-like", "refseq_ac": "NP_001100890", "gene_names_uniprotkb": "Rbmxl1; Rbmxrtl; Rbmx; Rbmxl1", "gene_names_refseq": "Rbmxl1; Rbmxrtl; Rbmxrt; Rbmx", "protein_names_uniprotkb": "RNA-binding motif protein, X chromosome retrogene-like; Heterogeneous nuclear ribonucleoprotein G retrogene-like; RNA-binding motif protein, X chromosome retrogene; hnRNP G", "protein_names_refseq": "RNA binding motif protein, X chromosome retrogene-like; RNA binding motif protein, X chromosome retrogene; RNA binding motif protein, X-linked-like 1; RNA-binding motif protein, X chromosome retrogene-like; heterogeneous nuclear ribonucleoprotein G retrogene-like; hnRNP G", "tax_id": 10116, "disease": "syndromic X-linked intellectual disability Shashi type (Disease Ontology:DOID:0060826); X-linked mental retardation Gustavson type (Disease Ontology:DOID:0081123)", "pathway": " (rno:307779)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;29393594;38843836", "class_list": "", "function": "RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of pre-mRNAs. Associates with chromatin. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Binds non-specifically to pre-mRNAs (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0070062 extracellular exosome;GO:0005681 spliceosomal complex;GO:0000791 euchromatin;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006509 membrane protein ectodomain proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051260 protein homooligomerization;GO:0048025 negative regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P84586-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97538-1", "uniprot_id": "RASM_RAT", "mass": 23887.0, "length": 208, "protein_name": "Ras-related protein M-Ras", "gene_name": "Mras", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mras; Rras3", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras-related protein M-Ras; 3.6.5.2; Ras-related protein R-Ras3", "protein_names_refseq": "", "tax_id": 10116, "disease": "Noonan syndrome 11 (Disease Ontology:DOID:0112169)", "pathway": " (R-RNO-5673000)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19319189;9395237", "class_list": "", "function": "Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). The formation of the SMP complex only occurs when MRAS is GTP-bound (By similarity). MRAS has low intrinsic GTPase activity and may require additional factors for activation (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09021", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;2.7.11.1;3.6.5.3;2.3.2.27;3.6.5.5;3.6.1.5;3.1.3.53;3.1.3.16;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030742 GTP-dependent protein binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0007265 Ras protein signal transduction;GO:0007163 establishment or maintenance of cell polarity;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97538-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97544-1", "uniprot_id": "PLPP3_RAT", "mass": 35318.0, "length": 312, "protein_name": "Phospholipid phosphatase 3", "gene_name": "Plpp3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Plpp3; Lpp3; Ppap2b", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipid phosphatase 3; 3.1.3.-; 3.1.3.4; Differentially expressed in rat intestine 42; Dri42; Lipid phosphate phosphohydrolase 3; PAP-2b; PAP2-beta; PAP2b; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-9845614)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11704545;8055940;8939937", "class_list": "", "function": "Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth. Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (By similarity). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.4;3.6.1.75;3.1.3.-;3.1.3.106;3.6.1.-;3.6.1.68", "go_molecular_function": "GO:0005178 integrin binding;GO:0070097 delta-catenin binding;GO:0008195 phosphatidate phosphatase activity;GO:0042577 lipid phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016020 membrane", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007229 integrin-mediated signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97544-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97574-1", "uniprot_id": "STC1_RAT", "mass": 27507.0, "length": 247, "protein_name": "Stanniocalcin-1", "gene_name": "Stc1", "organism": "Rat", "refseq_name": "stanniocalcin-1 precursor", "refseq_ac": "NP_112385", "gene_names_uniprotkb": "Stc1; Stc", "gene_names_refseq": "Stc1", "protein_names_uniprotkb": "Stanniocalcin-1; STC-1", "protein_names_refseq": "STC-1; stanniocalcin-1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:81801)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23877023;25251473;26187698;31314602;33025358", "class_list": "", "function": "AVP-mediated elevations in STC-1 gene expression are wholly dependent on functional COX-2 activity., [RefSeq, PubMed]; In this study, we have found that several HIF target genes including STC1 are upregulated in AECs by a submerged condition, that STC1 is regulated by hypoxia and HIF., [RefSeq, PubMed]; Results show that STC1 have an important role in the carbohydrate metabolism regulation, in particular gluconeogenesis from glutamine in the kidney, across the vertebrates., [RefSeq, PubMed]; Stanniocalcin 1 Inhibits the Inflammatory Response in Microglia and Protects Against Sepsis-Associated Encephalopathy., [RefSeq, PubMed]; Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity., [RefSeq, PubMed]; Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0006874 intracellular calcium ion homeostasis;GO:0030336 negative regulation of cell migration;GO:0071456 cellular response to hypoxia;GO:0051926 negative regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97574-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97680-1", "uniprot_id": "RIN1_RAT", "mass": 84727.0, "length": 774, "protein_name": "Ras and Rab interactor 1", "gene_name": "Rin1", "organism": "Rat", "refseq_name": "ras and Rab interactor 1", "refseq_ac": "NP_620607", "gene_names_uniprotkb": "Rin1", "gene_names_refseq": "Rin1", "protein_names_uniprotkb": "Ras and Rab interactor 1; Ras interaction/interference protein 1", "protein_names_refseq": "ras and Rab interactor 1; ras inhibitor; ras interaction/interference protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:207119); (R-RNO-8876198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9144171", "class_list": "", "function": "Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0007613 memory;GO:0008306 associative learning;GO:0031914 negative regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97680-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97831-1", "uniprot_id": "TWST2_RAT", "mass": 18124.0, "length": 160, "protein_name": "Twist-related protein 2", "gene_name": "Twist2", "organism": "Rat", "refseq_name": "twist-related protein 2", "refseq_ac": "NP_067723", "gene_names_uniprotkb": "Twist2", "gene_names_refseq": "Dermo1; Twist2", "protein_names_uniprotkb": "Twist-related protein 2", "protein_names_refseq": "dermo-1 protein; twist basic helix-loop-helix transcription factor 2; twist homolog 2; twist-related protein 2", "tax_id": 10116, "disease": "Barber-Say syndrome (Disease Ontology:DOID:0060549); ablepharon macrostomia syndrome (Disease Ontology:DOID:0060550); Saethre-Chotzen syndrome (Disease Ontology:DOID:14768)", "pathway": " (rno:59327)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28208580", "class_list": "", "function": "Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity)., [UniProtKB]; Twist2 gene expression was elevated following injury in both young and aged rats, and Twist2 protein expression is elevated by mercuric chloride in vitro. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q60981", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97831-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97844-1", "uniprot_id": "RGS1_RAT", "mass": 24096.0, "length": 209, "protein_name": "Regulator of G protein signaling 1", "gene_name": "Rgs1", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 1 isoform 2", "refseq_ac": "NP_062209", "gene_names_uniprotkb": "Rgs1", "gene_names_refseq": "Rgs1", "protein_names_uniprotkb": "Regulator of G protein signaling 1; RGS1", "protein_names_refseq": "regulator of G-protein signaling 1 isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:54289); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "29393594;31012109", "class_list": "", "function": "Functional suppression of RGS1 inhibits the inflammatory response and angiogenesis by inactivating the TLR signaling pathway in rats, [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0H2UHC4;Q4KM99", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0043547 positive regulation of GTPase activity;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97844-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P98087-1", "uniprot_id": "CBLN2_RAT", "mass": 24023.0, "length": 224, "protein_name": "Cerebellin-2", "gene_name": "Cbln2", "organism": "Rat", "refseq_name": "cerebellin-2 precursor", "refseq_ac": "NP_001012758", "gene_names_uniprotkb": "Cbln2", "gene_names_refseq": "Cbln2", "protein_names_uniprotkb": "Cerebellin-2; Cerebellin-like protein", "protein_names_refseq": "cerebellin 2 precursor protein; cerebellin-2 precursor; cerebellin-2; cerebellin-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:291388)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15702230;1850079;29784783;37355224", "class_list": "", "function": "Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for long-term maintenance but not establishment of excitatory synapses. Functions as part of a trans-synaptic complex by binding to postsynaptic GRID1 and presynaptic neurexins. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response., [UniProtKB, UniProtKB]; Cerebellin-2 promotes endothelial-mesenchymal transition in hypoxic pulmonary hypertension rats by activating NF-kappaB/HIF-1alpha/Twist1 pathway., [RefSeq, PubMed]; Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5BJT3", "ec_number_list": "", "go_molecular_function": "GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0045202 synapse;GO:0043083 synaptic cleft;GO:0098820 trans-synaptic protein complex", "go_biological_process": "GO:0050808 synapse organization;GO:0051965 positive regulation of synapse assembly;GO:0099558 maintenance of synapse structure;GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission;GO:0099550 trans-synaptic signaling, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P98087-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01750-1", "uniprot_id": "T2FB_RAT", "mass": 28349.0, "length": 249, "protein_name": "General transcription factor IIF subunit 2", "gene_name": "Gtf2f2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gtf2f2; Rap30", "gene_names_refseq": "", "protein_names_uniprotkb": "General transcription factor IIF subunit 2; TFIIF-beta; Transcription initiation factor IIF subunit beta; Transcription initiation factor RAP30", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:81674); (R-RNO-112382); (R-RNO-113418); (R-RNO-674695); (R-RNO-6796648); (R-RNO-6803529); (R-RNO-6807505); (R-RNO-72086); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075); (R-RNO-9018519); (R-RNO-9770562)", "pathway_count": 19, "publication_count": 2, "publication_id_list": "1429731;22673903", "class_list": "", "function": "TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0015630 microtubule cytoskeleton;GO:0005675 transcription factor TFIIH holo complex;GO:0005674 transcription factor TFIIF complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q01750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02445-1", "uniprot_id": "TFPI1_RAT", "mass": 34554.0, "length": 302, "protein_name": "Tissue factor pathway inhibitor", "gene_name": "Tfpi", "organism": "Rat", "refseq_name": "tissue factor pathway inhibitor isoform 1 precursor", "refseq_ac": "NP_058896", "gene_names_uniprotkb": "Tfpi", "gene_names_refseq": "Tfpi", "protein_names_uniprotkb": "Tissue factor pathway inhibitor; EPI; Extrinsic pathway inhibitor; LACI; Lipoprotein-associated coagulation inhibitor; TFPI", "protein_names_refseq": "EPI; LACI; extrinsic pathway inhibitor; lipoprotein-associated coagulation inhibitor; tissue factor pathway inhibitor isoform 1 precursor", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); atrial fibrillation (Disease Ontology:DOID:0060224); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); preterm premature rupture of the membranes (Disease Ontology:DOID:0111144); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); disseminated intravascular coagulation (Disease Ontology:DOID:11247); familial hyperlipidemia (Disease Ontology:DOID:1168); nephrotic syndrome (Disease Ontology:DOID:1184); factor VIII deficiency (Disease Ontology:DOID:12134); leukemia (Disease Ontology:DOID:1240); toxic shock syndrome (Disease Ontology:DOID:14115); disease of cellular proliferation (Disease Ontology:DOID:14566); factor V deficiency (Disease Ontology:DOID:2216); transient cerebral ischemia (Disease Ontology:DOID:224); protein S deficiency (Disease Ontology:DOID:2451); pulmonary fibrosis (Disease Ontology:DOID:3770); liver cirrhosis (Disease Ontology:DOID:5082); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); systemic lupus erythematosus (Disease Ontology:DOID:9074); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:29436); (R-RNO-9769739)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1639767;34876522", "class_list": "", "function": "Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Intersection of regulatory pathways controlling hemostasis and hemochorial placentation., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005901 caveola;GO:0005576 extracellular region", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0007596 blood coagulation;GO:0071222 cellular response to lipopolysaccharide;GO:0032355 response to estradiol;GO:0030195 negative regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q02445-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03336-1", "uniprot_id": "RGN_RAT", "mass": 33390.0, "length": 299, "protein_name": "Regucalcin", "gene_name": "Rgn", "organism": "Rat", "refseq_name": "regucalcin", "refseq_ac": "NP_113734", "gene_names_uniprotkb": "Rgn; Smp30", "gene_names_refseq": "GNL; Rc; Reguc; Rgn", "protein_names_uniprotkb": "Regucalcin; 3.1.1.17; GNL; Gluconolactonase; RC; SMP-30; Senescence marker protein 30", "protein_names_refseq": "SMP-30; gluconolactonase; regucalcin (senescence marker protein-30); regucalcin; senescence marker protein 30", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); familial hyperlipidemia (Disease Ontology:DOID:1168); hepatocellular carcinoma (Disease Ontology:DOID:684); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (rno:25106)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "1420310;15251439;16585534;22673903;29602294;33137709;35041836;38171814;8348951;8569761;8794449;8979263", "class_list": "", "function": "Expression of Regucalcin, a calcium-binding protein is regulated by hypoxia-inducible factor-1alpha., [RefSeq, PubMed]; Extracellular regucalcin suppresses colony formation and growth independent of tumor suppressor p53 in human mammary epithelial cells., [RefSeq, PubMed]; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Melatonin may produce a neuroprotective effect through its antioxidant action and by increasing hippocampal expression of SMP30 and osteopontin., [RefSeq, PubMed]; Release of SMP30 in Extracellular Vesicles under Conditions of Ascorbic Acid Deficiency Is Involved with Acute Phase Response in ODS Rat., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63496;Q925W3;Q9QWP2", "ec_number_list": "3.1.1.17", "go_molecular_function": "GO:0004341 gluconolactonase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1901318 negative regulation of flagellated sperm motility;GO:1903011 negative regulation of bone development;GO:1903611 negative regulation of calcium-dependent ATPase activity;GO:1903625 negative regulation of DNA catabolic process;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q03336-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05028-1", "uniprot_id": "PDGFB_RAT", "mass": 25603.0, "length": 225, "protein_name": "Platelet-derived growth factor subunit B", "gene_name": "Pdgfb", "organism": "Rat", "refseq_name": "platelet-derived growth factor subunit B precursor", "refseq_ac": "NP_113712", "gene_names_uniprotkb": "Pdgfb", "gene_names_refseq": "Pdgfb; SIS; c-sis", "protein_names_uniprotkb": "Platelet-derived growth factor subunit B; PDGF subunit B; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide", "protein_names_refseq": "PDGF subunit B; PDGF-2; Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis); pdgf protein; platelet derived growth factor, B polypeptide; platelet derived growth factor-bb; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor subunit B precursor", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); inflammatory bowel disease (Disease Ontology:DOID:0050589); basal ganglia calcification (Disease Ontology:DOID:0060230); COVID-19 (Disease Ontology:DOID:0080600); graft-versus-host disease (Disease Ontology:DOID:0081267); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); prostatic hypertrophy (Disease Ontology:DOID:11132); oligohydramnios (Disease Ontology:DOID:12215); leiomyoma (Disease Ontology:DOID:127); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); cholestasis (Disease Ontology:DOID:13580); Leydig cell tumor (Disease Ontology:DOID:2696); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); dermatofibrosarcoma protuberans (Disease Ontology:DOID:3507); choriocarcinoma (Disease Ontology:DOID:3594); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); familial meningioma (Disease Ontology:DOID:4586); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:24628); (R-RNO-114608); (R-RNO-1257604); (R-RNO-186763); (R-RNO-186797); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "29786113;30257103;32647179;33520084;7758166;8318539", "class_list": "", "function": "Csis inhibited the H2O2induced apoptosis of Buffalo rat liver cells in vitro, and alleviated liver injury, improved liver function, and decreased mortality rates in rat models of fulminant hepatic failure., [RefSeq, PubMed]; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In cultured rat aortic SMCs, PDGF stimulation rapidly promoted ATP7A association with IQGAP1 and Rac1 and their translocation to the lipid rafts and leading edge. Cotransfection assay revealed that ATP7A directly bound to NH2-terminal domain of IQGAP1, [RefSeq, PubMed]; Overexpression of MiR-29b-3p Inhibits Atrial Remodeling in Rats by Targeting PDGF-B Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Tensile force-induced PDGF-BB/PDGFRbeta signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0005102 signaling receptor binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:1904385 cellular response to angiotensin;GO:0021782 glial cell development;GO:0072264 metanephric glomerular endothelium development;GO:2000491 positive regulation of hepatic stellate cell activation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q05028-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06332-1", "uniprot_id": "TNFB_RAT", "mass": 22112.0, "length": 202, "protein_name": "Lymphotoxin-alpha", "gene_name": "Lta", "organism": "Rat", "refseq_name": "lymphotoxin-alpha precursor", "refseq_ac": "NP_542947", "gene_names_uniprotkb": "Lta; Tnfb; Tnfsf1", "gene_names_refseq": "Lta; Tnfb", "protein_names_uniprotkb": "Lymphotoxin-alpha; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1", "protein_names_refseq": "LT-alpha; TNF-beta; lymphotoxin A; lymphotoxin alpha (TNF superfamily, member 1); lymphotoxin-alpha precursor; lymphotoxin-alpha-like; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); chorioamnionitis (Disease Ontology:DOID:0050697); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); erythema nodosum (Disease Ontology:DOID:0080750); traumatic brain injury (Disease Ontology:DOID:0081292); leprosy (Disease Ontology:DOID:1024); bacterial infectious disease (Disease Ontology:DOID:104); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); hypertension (Disease Ontology:DOID:10763); adult respiratory distress syndrome (Disease Ontology:DOID:11394); allergic disease (Disease Ontology:DOID:1205); Graves' disease (Disease Ontology:DOID:12361); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); typhoid fever (Disease Ontology:DOID:13258); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); melanoma (Disease Ontology:DOID:1909); hyperinsulinism (Disease Ontology:DOID:2018); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); high grade glioma (Disease Ontology:DOID:3070); tracheal stenosis (Disease Ontology:DOID:3227); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); cerebral infarction (Disease Ontology:DOID:3526); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); pustulosis of palm and sole (Disease Ontology:DOID:4398); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); dermatitis herpetiformis (Disease Ontology:DOID:8505); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); psoriatic arthritis (Disease Ontology:DOID:9008); visceral leishmaniasis (Disease Ontology:DOID:9146); mucocutaneous leishmaniasis (Disease Ontology:DOID:9155); type 2 diabetes mellitus (Disease Ontology:DOID:9352); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25008); (R-RNO-5668541); (R-RNO-5669034); (R-RNO-5676594)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "15060004;33441130;35776111;8224868", "class_list": "", "function": "Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo., [UniProtKB, UniProtKB]; Elevated lymphotoxin-alpha (TNFbeta) is associated with intervertebral disc degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 52, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0002947 tumor necrosis factor receptor superfamily complex", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q06332-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06645-1", "uniprot_id": "AT5G1_RAT", "mass": 14244.0, "length": 136, "protein_name": "ATP synthase F(0) complex subunit C1, mitochondrial", "gene_name": "Atp5mc1", "organism": "Rat", "refseq_name": "ATP synthase F(0) complex subunit C1, mitochondrial precursor", "refseq_ac": "NP_059007", "gene_names_uniprotkb": "Atp5mc1; Atp5g1", "gene_names_refseq": "Atp5g1; Atp5mc1", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit C1, mitochondrial; ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1; ATP synthase proteolipid P1; ATPase protein 9; ATPase subunit c; Proton-conducting channel, ATP synthase F(0) complex subunit c", "protein_names_refseq": "ATP synthase F(0) complex subunit C1, mitochondrial precursor; ATP synthase F(0) complex subunit C1, mitochondrial; ATP synthase H+ transporting mitochondrial F0 complex subunit c (subunit 9); ATP synthase lipid-binding protein, mitochondrial; ATP synthase proteolipid P1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9); ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9); ATPase protein 9; ATPase subunit c; proton-conducting channel, ATP synthase F(0) complex subunit c", "tax_id": 10116, "disease": "early-onset dystonia and/or spastic paraplegia (Disease Ontology:DOID:0070445); mitochondrial complex V (ATP synthase) deficiency (Disease Ontology:DOID:0111143)", "pathway": " (rno:29754); (R-RNO-163210); (R-RNO-8949613)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17575325;22209705;22773120;23343770;30530489;8448208", "class_list": "", "function": "Data show that microRNA-338 (miR-338) modulation of local cytochrome c oxidase IV (COXIV) and ATP synthase subunit 9 (ATP5G1) expression has a marked effect on axonal reactive oxygen species levels, as well as axonal growth., [RefSeq, PubMed]; Subunit c, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. With the subunit a (MT-ATP6), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix. Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism., [UniProtKB, UniProtKB]; The c subunit of the F0 ATP synthase constitutes a critical component of the mitochondrial permeability transition pore., [RefSeq, PubMed]; The siRNA-mediated knock-down of axonal ATP5G1 mRNA resulted in a significant reduction of axonal ATP5G1 protein and ATP levels. Silencing of local ATP5G1 expression enhanced the production of local reactive oxygen species., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0015252 proton channel activity", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain", "go_biological_process": "GO:0045471 response to ethanol;GO:0046931 pore complex assembly;GO:0015986 proton motive force-driven ATP synthesis;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06645-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07984-1", "uniprot_id": "SSRD_RAT", "mass": 18980.0, "length": 173, "protein_name": "Translocon-associated protein subunit delta", "gene_name": "Ssr4", "organism": "Rat", "refseq_name": "translocon-associated protein subunit delta precursor", "refseq_ac": "NP_058895", "gene_names_uniprotkb": "Ssr4", "gene_names_refseq": "Ssr4", "protein_names_uniprotkb": "Translocon-associated protein subunit delta; SSR-delta; Signal sequence receptor subunit delta; TRAP-delta", "protein_names_refseq": "SSR-delta; TRAP-delta; signal sequence receptor 4; signal sequence receptor subunit delta; signal sequence receptor, delta; translocon-associated protein subunit delta precursor; translocon-associated protein subunit delta", "tax_id": 10116, "disease": "congenital disorder of glycosylation Iy (Disease Ontology:DOID:0080574)", "pathway": " (rno:29435)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7916687", "class_list": "", "function": "TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0012505 endomembrane system;GO:0005784 Sec61 translocon complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q07984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08420-1", "uniprot_id": "SODE_RAT", "mass": 26620.0, "length": 244, "protein_name": "Extracellular superoxide dismutase [Cu-Zn]", "gene_name": "Sod3", "organism": "Rat", "refseq_name": "extracellular superoxide dismutase [Cu-Zn] precursor", "refseq_ac": "NP_037012", "gene_names_uniprotkb": "Sod3; Sod-3", "gene_names_refseq": "ECSODPT; Sod3", "protein_names_uniprotkb": "Extracellular superoxide dismutase [Cu-Zn]; 1.15.1.1; EC-SOD; Superoxide dismutase B", "protein_names_refseq": "EC-SOD; Superoxide dimutase 3; extracellular superoxide dismutase [Cu-Zn] precursor; extracellular superoxide dismutase; superoxide dismutase 3, extracellular; superoxide dismutase B", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); polyneuropathy (Disease Ontology:DOID:1389); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); oral cavity cancer (Disease Ontology:DOID:8618); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25352); (R-RNO-3299685)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "31714656;31972339;36251410;36989187;8227019;8328962;8643556", "class_list": "", "function": "Changes in superoxide dismutase 3 (SOD3) expression in periodontal tissue during orthodontic tooth movement of rat molars and the effect of SOD3 on in vitro hypoxia-exposed rat periodontal ligament cells., [RefSeq, PubMed]; Degeneration of biological heart valve grafts in a rat model of superoxide dismutase-3 deficiency., [RefSeq, PubMed]; Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3., [RefSeq, PubMed]; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen., [UniProtKB]; The characteristic regulation of gene expression Lbp and Sod3 in peri-implant connective tissue of rats., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64667", "ec_number_list": "1.8.-.-;1.15.1.1;1.11.1.-;1.7.-.-;1.14.12.-", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005507 copper ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0001666 response to hypoxia;GO:0097746 blood vessel diameter maintenance;GO:0046688 response to copper ion;GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08420-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q27W01-1", "uniprot_id": "RBM8A_RAT", "mass": 19889.0, "length": 174, "protein_name": "RNA-binding protein 8A", "gene_name": "Rbm8a", "organism": "Rat", "refseq_name": "RNA-binding protein 8A", "refseq_ac": "NP_001258067", "gene_names_uniprotkb": "Rbm8a; Rbm8", "gene_names_refseq": "Rbm8a; Rbm8", "protein_names_uniprotkb": "RNA-binding protein 8A; RNA-binding motif protein 8A; Ribonucleoprotein RBM8A", "protein_names_refseq": "RNA binding motif protein 8; RNA-binding protein 8A; ribonucleoprotein RBM8A", "tax_id": 10116, "disease": "thrombocytopenia-absent radius syndrome (Disease Ontology:DOID:14699)", "pathway": " (rno:295284); (R-RNO-159236); (R-RNO-72163); (R-RNO-975957)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "16275927;22673903", "class_list": "", "function": "Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q27W01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29YR5-1", "uniprot_id": "ST2B1_RAT", "mass": 38322.0, "length": 340, "protein_name": "Sulfotransferase 2B1", "gene_name": "Sult2b1", "organism": "Rat", "refseq_name": "sulfotransferase 2B1", "refseq_ac": "NP_001034754", "gene_names_uniprotkb": "Sult2b1", "gene_names_refseq": "ST2B1; Sult2b1", "protein_names_uniprotkb": "Sulfotransferase 2B1; 2.8.2.2; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2; ST2B1; Sulfotransferase family cytosolic 2B member 1", "protein_names_refseq": "alcohol sulfotransferase; hydroxysteroid sulfotransferase 2; sulfotransferase 2B1; sulfotransferase 2B; sulfotransferase family, cytosolic, 2B, member 1", "tax_id": 10116, "disease": "autosomal recessive congenital ichthyosis 14 (Disease Ontology:DOID:0080258)", "pathway": " (rno:292915); (R-RNO-156584)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16368200;22673903;26739637", "class_list": "", "function": "Prefers pregnenolone over DHEA as a substrate and does not sulfate cholesterol., [UniProtKB, PubMed]; Since 1'-hydroxyestragole exposure readily produced DNA injury in B-13/H cells, these data suggest that cholangiocarcinomas generated in rats fed estragole may be dependent, in part, on SULT2B1 activation of the 1'-hydroxyestragole metabolite., [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfonates cholesterol (PubMed:16368200). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:16368200). Conjugates efficiently cholesterol but has a greater affinity for pregnenolone sulfation. Does not show high activity with DHEA (PubMed:16368200). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29YR6", "ec_number_list": "2.8.2.-;2.8.2.14;2.8.2.2;2.8.2.4;2.8.2.1", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050294 steroid sulfotransferase activity;GO:0015485 cholesterol binding;GO:0003676 nucleic acid binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0008203 cholesterol metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0045606 positive regulation of epidermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q29YR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3B7D1-1", "uniprot_id": "UBE2Z_RAT", "mass": 38352.0, "length": 356, "protein_name": "Ubiquitin-conjugating enzyme E2 Z", "gene_name": "Ube2z", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 Z", "refseq_ac": "NP_001032732", "gene_names_uniprotkb": "Ube2z", "gene_names_refseq": "RGD1308347; Ube2z", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 Z; 2.3.2.23; E2 ubiquitin-conjugating enzyme Z; Uba6-specific E2 conjugating enzyme 1; Ubiquitin carrier protein Z; Ubiquitin-protein ligase Z; Use1", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme Z; uba6-specific E2 conjugating enzyme 1; ubiquitin carrier protein Z; ubiquitin-conjugating enzyme E2 Z; ubiquitin-conjugating enzyme E2Z (putative); ubiquitin-protein ligase Z; use1", "tax_id": 10116, "disease": "", "pathway": " (rno:303478); (R-RNO-8866652); (R-RNO-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;39084457", "class_list": "", "function": "BMSC-derived exosomal miR-219-5p alleviates ferroptosis in neuronal cells caused by spinal cord injury via the UBE2Z/NRF2 pathway., [RefSeq, PubMed]; Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.32;2.3.2.31;2.3.2.23;2.3.2.27;2.3.2.34;2.3.2.24;2.3.2.-;2.3.2.25;6.2.1.45;6.2.1.64", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3B7D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3B7D9-1", "uniprot_id": "RBM43_RAT", "mass": 38866.0, "length": 343, "protein_name": "RNA-binding protein 43", "gene_name": "Rbm43", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rbm43", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA-binding protein 43; RNA-binding motif protein 43", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:311020)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7D9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3KRD5-1", "uniprot_id": "TOM34_RAT", "mass": 34461.0, "length": 309, "protein_name": "Mitochondrial import receptor subunit TOM34", "gene_name": "Tomm34", "organism": "Rat", "refseq_name": "mitochondrial import receptor subunit TOM34", "refseq_ac": "NP_001037709", "gene_names_uniprotkb": "Tomm34", "gene_names_refseq": "Tomm34", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM34; Translocase of outer membrane 34 kDa subunit", "protein_names_refseq": "mitochondrial import receptor subunit TOM34; translocase of outer membrane 34 kDa subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:311621)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006626 protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3KRD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3T1I3-1", "uniprot_id": "USBP1_RAT", "mass": 74612.0, "length": 680, "protein_name": "Harmonin-binding protein USHBP1", "gene_name": "Ushbp1", "organism": "Rat", "refseq_name": "harmonin-binding protein USHBP1", "refseq_ac": "NP_001028859", "gene_names_uniprotkb": "Ushbp1", "gene_names_refseq": "Ushbp1", "protein_names_uniprotkb": "Harmonin-binding protein USHBP1; USH1C-binding protein 1; Usher syndrome type-1C protein-binding protein 1", "protein_names_refseq": "USH1C-binding protein 1; Usher syndrome 1C binding protein 1; harmonin-binding protein USHBP1; usher syndrome type-1C protein-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:290629)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030165 PDZ domain binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T1I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q498T4-1", "uniprot_id": "RM02_RAT", "mass": 32999.0, "length": 304, "protein_name": "Large ribosomal subunit protein uL2m", "gene_name": "Mrpl2", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL2m precursor", "refseq_ac": "NP_001029308", "gene_names_uniprotkb": "Mrpl2", "gene_names_refseq": "Mrpl2", "protein_names_uniprotkb": "Large ribosomal subunit protein uL2m; 39S ribosomal protein L2, mitochondrial; L2mt; MRP-L2", "protein_names_refseq": "39S ribosomal protein L2, mitochondrial; L2mt; MRP-L2; large ribosomal subunit protein uL2m precursor; large ribosomal subunit protein uL2m", "tax_id": 10116, "disease": "", "pathway": " (rno:301240); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q498T4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q498U0-1", "uniprot_id": "SRALN_RAT", "mass": 7370.0, "length": 65, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN", "gene_name": "Arln", "organism": "Rat", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN", "refseq_ac": "NP_001258045", "gene_names_uniprotkb": "Arln", "gene_names_refseq": "ALN; Arln; C2h4orf3", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN; ALN; Allregulin; Another-regulin; SERCA regulator ARLN", "protein_names_refseq": "SERCA regulator ALN; SERCA regulator ARLN; another-regulin; sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ALN; sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN; uncharacterized protein C4orf3 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:691807)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Inhibits the activity of the calcium ATPases ATP2A2/SERCA2 and ATP2A3/SERCA3 by decreasing their apparent affinity for Ca(2+)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1901895 negative regulation of ATPase-coupled calcium transmembrane transporter activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q498U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499S9-1", "uniprot_id": "RHDF1_RAT", "mass": 97262.0, "length": 856, "protein_name": "Inactive rhomboid protein 1", "gene_name": "Rhbdf1", "organism": "Rat", "refseq_name": "inactive rhomboid protein 1 isoform 3", "refseq_ac": "NP_001025205", "gene_names_uniprotkb": "Rhbdf1", "gene_names_refseq": "Rhbdf1", "protein_names_uniprotkb": "Inactive rhomboid protein 1; Rhomboid family member 1; iRhom1", "protein_names_refseq": "iRhom1; inactive rhomboid protein 1 isoform 3; inactive rhomboid protein 1; rhomboid family 1; rhomboid family member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:303008)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019838 growth factor binding;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0008283 cell population proliferation;GO:0015031 protein transport;GO:0016477 cell migration;GO:0050708 regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499S9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4FZU4-1", "uniprot_id": "ATL4_RAT", "mass": 112785.0, "length": 1030, "protein_name": "ADAMTS-like protein 4", "gene_name": "Adamtsl4", "organism": "Rat", "refseq_name": "ADAMTS-like protein 4 precursor", "refseq_ac": "NP_001029184", "gene_names_uniprotkb": "Adamtsl4", "gene_names_refseq": "Adamtsl4; Tsrc1", "protein_names_uniprotkb": "ADAMTS-like protein 4; ADAMTSL-4", "protein_names_refseq": "ADAMTS-like protein 4 precursor; ADAMTS-like protein 4; ADAMTSL-4; thrombospondin repeat protein 1", "tax_id": 10116, "disease": "autosomal recessive isolated ectopia lentis 2 (Disease Ontology:DOID:0111149); ectopia lentis with ectopia of pupil (Disease Ontology:DOID:0111648); lens disease (Disease Ontology:DOID:110); craniosynostosis (Disease Ontology:DOID:2340)", "pathway": " (rno:310670); (R-RNO-5173214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 2, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005614 interstitial matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0002064 epithelial cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4G019-1", "uniprot_id": "SPTSA_RAT", "mass": 8452.0, "length": 71, "protein_name": "Serine palmitoyltransferase small subunit A", "gene_name": "Sptssa", "organism": "Rat", "refseq_name": "serine palmitoyltransferase small subunit A", "refseq_ac": "NP_001041208", "gene_names_uniprotkb": "Sptssa; Ssspta", "gene_names_refseq": "Sptssa; Ssspta", "protein_names_uniprotkb": "Serine palmitoyltransferase small subunit A; Small subunit of serine palmitoyltransferase A; ssSPTa", "protein_names_refseq": "serine palmitoyltransferase small subunit A; small subunit of serine palmitoyltransferase A", "tax_id": 10116, "disease": "hereditary spastic paraplegia 90A (Disease Ontology:DOID:0070459); hereditary spastic paraplegia 90B (Disease Ontology:DOID:0070460)", "pathway": " (rno:500651); (R-RNO-1660661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSA stimulates the catalytic activity and plays a role in substrate specificity, which depends upon the overall complex composition. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Independently of its action as a SPT component, may be involved in MBOAT7 localization to mitochondria-associated membranes, a membrane bridge between the endoplasmic reticulum and mitochondria, may hence affect MBOAT7-catalyzed incorporation of arachidonic acid into phosphatidylinositol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004758 serine C-palmitoyltransferase activity", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0046512 sphingosine biosynthetic process;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4G019-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4G2Y1-1", "uniprot_id": "RIP_RAT", "mass": 24710.0, "length": 219, "protein_name": "RPA-interacting protein", "gene_name": "Rpain", "organism": "Rat", "refseq_name": "RPA-interacting protein", "refseq_ac": "NP_001028232", "gene_names_uniprotkb": "Rpain; Rip", "gene_names_refseq": "RGD1308492; Rpain", "protein_names_uniprotkb": "RPA-interacting protein", "protein_names_refseq": "RAP interaction protein alpha; RPA-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:287463)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15277470;16008515;29393594", "class_list": "", "function": "Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Sumoylation mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016605 PML body", "go_biological_process": "GO:0009411 response to UV;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4G2Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KLK8-1", "uniprot_id": "PXDC1_RAT", "mass": 26360.0, "length": 231, "protein_name": "PX domain-containing protein 1", "gene_name": "Pxdc1", "organism": "Rat", "refseq_name": "PX domain-containing protein 1", "refseq_ac": "NP_001020890", "gene_names_uniprotkb": "Pxdc1", "gene_names_refseq": "Pxdc1; RGD1311307", "protein_names_uniprotkb": "PX domain-containing protein 1", "protein_names_refseq": "PX domain-containing protein 1; PX domain-containing protein C6orf145 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:361238)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KLK9-1", "uniprot_id": "SSU72_RAT", "mass": 22544.0, "length": 194, "protein_name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "gene_name": "Ssu72", "organism": "Rat", "refseq_name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "refseq_ac": "NP_001020828", "gene_names_uniprotkb": "Ssu72", "gene_names_refseq": "RGD1307854; Ssu72", "protein_names_uniprotkb": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72; 3.1.3.16; CTD phosphatase SSU72", "protein_names_refseq": "CTD phosphatase SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "tax_id": 10116, "disease": "liver disease (Disease Ontology:DOID:409)", "pathway": " (rno:298681); (R-RNO-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.53;3.1.3.52;2.7.7.6;3.1.3.67;3.1.3.-;3.1.3.27;2.7.11.22;2.7.11.23;2.7.11.24;2.3.1.48;3.1.27.-;3.1.3.74", "go_molecular_function": "GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006369 termination of RNA polymerase II transcription;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KLN6-1", "uniprot_id": "RIR2_RAT", "mass": 45039.0, "length": 390, "protein_name": "Ribonucleoside-diphosphate reductase subunit M2", "gene_name": "Rrm2", "organism": "Rat", "refseq_name": "ribonucleoside-diphosphate reductase subunit M2", "refseq_ac": "NP_001020911", "gene_names_uniprotkb": "Rrm2", "gene_names_refseq": "Rrm2", "protein_names_uniprotkb": "Ribonucleoside-diphosphate reductase subunit M2; 1.17.4.1; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit", "protein_names_refseq": "Ribonucleotide reductase 2; ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase M2 polypeptide; ribonucleotide reductase small chain; ribonucleotide reductase small subunit", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); pancreatic cancer (Disease Ontology:DOID:1793); endometrial adenocarcinoma (Disease Ontology:DOID:2870); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:362720); (R-RNO-499943)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21925507;34868394", "class_list": "", "function": "Overexpression of the ribonucleotide reductase (Rrm1 and Rrm2) complex would increase contractility of adult rat cardiomyocytes., [RefSeq, PubMed]; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Inhibits Wnt signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; RRM2 Improves Cardiomyocyte Proliferation after Myocardial Ischemia Reperfusion Injury through the Hippo-YAP Pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.17.4.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;GO:0008199 ferric iron binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005971 ribonucleoside-diphosphate reductase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0008284 positive regulation of cell population proliferation;GO:0051290 protein heterotetramerization;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0009263 deoxyribonucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KLN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KLN8-1", "uniprot_id": "RNF8_RAT", "mass": 55615.0, "length": 487, "protein_name": "E3 ubiquitin-protein ligase RNF8", "gene_name": "Rnf8", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF8", "refseq_ac": "NP_001020898", "gene_names_uniprotkb": "Rnf8", "gene_names_refseq": "Rnf8", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF8; 2.3.2.27; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF8; RING-type E3 ubiquitin transferase RNF8; ring finger protein 8, E3 ubiquitin protein ligase", "tax_id": 10116, "disease": "", "pathway": " (rno:361815); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-69473)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "29097665", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Promotes the recruitment of NBN to DNA damage sites by catalyzing 'Lys-6'-linked ubiquitination of NBN. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (By similarity). Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (By similarity). In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2 (By similarity)., [UniProtKB, HAMAP, UniProtKB]; Knockdown or conditional knockout of RNF8 or UBC13 in rodent cerebellar granule neurons robustly increases the number of parallel fiber presynaptic boutons and functional parallel fiber/Purkinje cell synapses. In contrast to the role of nuclear RNF8 in proliferating cells, RNF8 operates in the cytoplasm in neurons to suppress synapse differentiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;1.14.11.69;1.14.11.66;2.7.11.1;3.4.19.-;2.3.2.27;2.1.1.357;3.1.3.16;2.3.2.-;3.1.-.-;2.3.1.48;2.3.1.-;2.3.2.23;3.6.-.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KM93-1", "uniprot_id": "TM177_RAT", "mass": 34001.0, "length": 311, "protein_name": "Transmembrane protein 177", "gene_name": "Tmem177", "organism": "Rat", "refseq_name": "transmembrane protein 177", "refseq_ac": "NP_001032865", "gene_names_uniprotkb": "Tmem177", "gene_names_refseq": "RGD1310320; Tmem177", "protein_names_uniprotkb": "Transmembrane protein 177", "protein_names_refseq": "transmembrane protein 177", "tax_id": 10116, "disease": "", "pathway": " (rno:304735); (R-RNO-9864848)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4PJT6-1", "uniprot_id": "SPA24_RAT", "mass": 23718.0, "length": 205, "protein_name": "Spermatogenesis-associated protein 24", "gene_name": "Spata24", "organism": "Rat", "refseq_name": "spermatogenesis-associated protein 24", "refseq_ac": "NP_001020807", "gene_names_uniprotkb": "Spata24", "gene_names_refseq": "RGD1311742; Spata24", "protein_names_uniprotkb": "Spermatogenesis-associated protein 24; Testis protein T6441", "protein_names_refseq": "spermatogenesis-associated protein 24; testis protein T6441", "tax_id": 10116, "disease": "", "pathway": " (rno:291676)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16146721;19515240", "class_list": "", "function": "Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter (By similarity). May play a role in cytoplasm movement and removal during spermiogenesis., [UniProtKB, PubMed]; The T6441 gene may play a role in cytoplasm movement and removal during spermiogenesis Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZAG4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4PJT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QQS2-1", "uniprot_id": "I70A2_RAT", "mass": 76065.0, "length": 664, "protein_name": "Intraflagellar transport protein 70A2", "gene_name": "Ift70a2", "organism": "Rat", "refseq_name": "intraflagellar transport protein 70A2", "refseq_ac": "NP_001025089", "gene_names_uniprotkb": "Ift70a2; Ttc30a1; Ttc30a2", "gene_names_refseq": "Ift70a2; Ttc30a1; Ttc30a2", "protein_names_uniprotkb": "Intraflagellar transport protein 70A2; TPR repeat protein 30A2; Tetratricopeptide repeat protein 30A2", "protein_names_refseq": "TPR repeat protein 30A2; intraflagellar transport protein 70A2; tetratricopeptide repeat domain 30A1; tetratricopeptide repeat domain 30A2; tetratricopeptide repeat protein 30A2", "tax_id": 10116, "disease": "", "pathway": " (rno:311123); (R-RNO-5620924)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0005879 axonemal microtubule;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QQS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QQW1-1", "uniprot_id": "REEP4_RAT", "mass": 29660.0, "length": 257, "protein_name": "Receptor expression-enhancing protein 4", "gene_name": "Reep4", "organism": "Rat", "refseq_name": "receptor expression-enhancing protein 4", "refseq_ac": "NP_001020450", "gene_names_uniprotkb": "Reep4", "gene_names_refseq": "RGD1306561; Reep4", "protein_names_uniprotkb": "Receptor expression-enhancing protein 4", "protein_names_refseq": "receptor expression-enhancing protein 4", "tax_id": 10116, "disease": "hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782)", "pathway": " (rno:306014)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16396499;22673903", "class_list": "", "function": "Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule;GO:0071782 endoplasmic reticulum tubular network;GO:0005874 microtubule", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0051301 cell division;GO:0007084 mitotic nuclear membrane reassembly;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4QQW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QQW8-1", "uniprot_id": "PLBL2_RAT", "mass": 65456.0, "length": 585, "protein_name": "Putative aminopeptidase PLBD2", "gene_name": "Plbd2", "organism": "Rat", "refseq_name": "putative aminopeptidase PLBD2 precursor", "refseq_ac": "NP_640348", "gene_names_uniprotkb": "Plbd2; RDCR-0918-3", "gene_names_refseq": "P76; Plbd2", "protein_names_uniprotkb": "Putative aminopeptidase PLBD2; 3.4.11.-; LAMA-like protein 2; Lamina ancestor homolog 2; Phospholipase B domain-containing protein 2", "protein_names_refseq": "LAMA-like protein 2; RDCR-0918-3 protein; lamina ancestor homolog 2; mannose-6-phosphate protein p76; phospholipase B domain-containing protein 2; putative aminopeptidase PLBD2 precursor; putative aminopeptidase PLBD2; putative phospholipase B-like 2", "tax_id": 10116, "disease": "", "pathway": " (rno:246120)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17105447;29393594", "class_list": "", "function": "Putative aminopeptidase., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A0JN10;Q3MHS4;Q5RJZ9;Q8K1I4", "ec_number_list": "", "go_molecular_function": "GO:0004620 phospholipase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4QQW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QR82-1", "uniprot_id": "RASF6_RAT", "mass": 39794.0, "length": 341, "protein_name": "Ras association domain-containing protein 6", "gene_name": "Rassf6", "organism": "Rat", "refseq_name": "ras association domain-containing protein 6", "refseq_ac": "NP_001020842", "gene_names_uniprotkb": "Rassf6", "gene_names_refseq": "Rassf6", "protein_names_uniprotkb": "Ras association domain-containing protein 6", "protein_names_refseq": "Ras association (RalGDS/AF-6) domain family member 6; ras association domain-containing protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:305251)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the induction of apoptosis. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QR82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7B2-1", "uniprot_id": "CD051_RAT", "mass": 23623.0, "length": 208, "protein_name": "Uncharacterized protein C4orf51 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "uncharacterized protein C4orf51 homolog", "refseq_ac": "NP_001020935", "gene_names_uniprotkb": "", "gene_names_refseq": "C19h4orf51", "protein_names_uniprotkb": "Uncharacterized protein C4orf51 homolog", "protein_names_refseq": "uncharacterized protein C4orf51 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:498933)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7D2-1", "uniprot_id": "ROGDI_RAT", "mass": 32205.0, "length": 287, "protein_name": "Protein rogdi homolog", "gene_name": "Rogdi", "organism": "Rat", "refseq_name": "protein rogdi homolog", "refseq_ac": "NP_001020035", "gene_names_uniprotkb": "Rogdi", "gene_names_refseq": "Rogdi", "protein_names_uniprotkb": "Protein rogdi homolog", "protein_names_refseq": "leucine zipper domain protein; protein rogdi homolog; rogdi homolog; rogdi-like protein", "tax_id": 10116, "disease": "Kohlschutter-Tonz syndrome (Disease Ontology:DOID:0111668)", "pathway": " (rno:287061)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29150638", "class_list": "", "function": "Green fluorescent protein-Rogdi harbours efficient signals for presynaptic targeting, and that Rogdi is a presynaptic protein. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0043291 RAVE complex;GO:0005635 nuclear envelope;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0007613 memory;GO:0007626 locomotory behavior;GO:0008284 positive regulation of cell population proliferation;GO:0050905 neuromuscular process;GO:0050877 nervous system process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7D2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7D7-1", "uniprot_id": "RBM22_RAT", "mass": 46864.0, "length": 420, "protein_name": "Pre-mRNA-splicing factor RBM22", "gene_name": "Rbm22", "organism": "Rat", "refseq_name": "pre-mRNA-splicing factor RBM22", "refseq_ac": "NP_001020847", "gene_names_uniprotkb": "Rbm22", "gene_names_refseq": "Rbm22", "protein_names_uniprotkb": "Pre-mRNA-splicing factor RBM22; RNA-binding motif protein 22", "protein_names_refseq": "pre-mRNA-splicing factor RBM22", "tax_id": 10116, "disease": "", "pathway": " (rno:307410); (R-RNO-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0008270 zinc ion binding;GO:0048306 calcium-dependent protein binding;GO:0017070 U6 snRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0033120 positive regulation of RNA splicing;GO:0046827 positive regulation of protein export from nucleus;GO:0071466 cellular response to xenobiotic stimulus;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7E5-1", "uniprot_id": "RF1ML_RAT", "mass": 42343.0, "length": 373, "protein_name": "Peptide chain release factor 1-like, mitochondrial", "gene_name": "Mtrf1l", "organism": "Rat", "refseq_name": "peptide chain release factor 1-like, mitochondrial precursor", "refseq_ac": "NP_001020894", "gene_names_uniprotkb": "Mtrf1l", "gene_names_refseq": "Mtrf1l", "protein_names_uniprotkb": "Peptide chain release factor 1-like, mitochondrial; Mitochondrial translational release factor 1-like", "protein_names_refseq": "mitochondrial translational release factor 1-like; peptide chain release factor 1-like, mitochondrial precursor; peptide chain release factor 1-like, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:361473); (R-RNO-5419276)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003747 translation release factor activity;GO:0016149 translation release factor activity, codon specific", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0070126 mitochondrial translational termination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7E5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V898-1", "uniprot_id": "RBMX_RAT", "mass": 42258.0, "length": 390, "protein_name": "RNA-binding motif protein, X chromosome", "gene_name": "Rbmx", "organism": "Rat", "refseq_name": "RNA-binding motif protein, X chromosome", "refseq_ac": "NP_001020834", "gene_names_uniprotkb": "Rbmx; Rbmxrt", "gene_names_refseq": "Rbmx; hnRNP G; hnRNP-G", "protein_names_uniprotkb": "RNA-binding motif protein, X chromosome; Heterogeneous nuclear ribonucleoprotein G; RNA-binding motif protein, X chromosome retrogene-like; RNA-binding motif protein, X chromosome retrogene; hnRNP G", "protein_names_refseq": "RNA binding motif protein, X chromosome; RNA-binding motif protein, X chromosome retrogene; RNA-binding motif protein, X chromosome; heterogeneous nuclear ribonucleoprotein G", "tax_id": 10116, "disease": "syndromic X-linked intellectual disability Shashi type (Disease Ontology:DOID:0060826); X-linked mental retardation Gustavson type (Disease Ontology:DOID:0081123)", "pathway": " (rno:302855); (R-RNO-72163); (R-RNO-72203); (R-RNO-9013418); (R-RNO-9013422); (R-RNO-9696264); (R-RNO-9696270); (R-RNO-9696273); (R-RNO-9770562)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "15009664;16128803;17188681;18683930;19282290;23180094;25407628;38843836", "class_list": "", "function": "RBMX immunoreactivity was found in neurons and astrocytes, but not in microglia after spinal cord injury., [RefSeq, PubMed]; RBMX might play a significant role in the degenerative process of retinal ganglion cells after light-induced damage in the retina., [RefSeq, PubMed]; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0014069 postsynaptic density;GO:0070062 extracellular exosome", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q4V898-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8C4-1", "uniprot_id": "WDR5B_RAT", "mass": 36049.0, "length": 328, "protein_name": "WD repeat-containing protein 5B", "gene_name": "Wdr5b", "organism": "Rat", "refseq_name": "WD repeat-containing protein 5B", "refseq_ac": "NP_001019937", "gene_names_uniprotkb": "Wdr5b", "gene_names_refseq": "Wdr5b", "protein_names_uniprotkb": "WD repeat-containing protein 5B", "protein_names_refseq": "WD repeat-containing protein 5B", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:303907)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the proliferation of retinal pigment epithelial (RPE) cells (By similarity). May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048188 Set1C/COMPASS complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8C4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8F3-1", "uniprot_id": "RHBL4_RAT", "mass": 35879.0, "length": 316, "protein_name": "Rhomboid-related protein 4", "gene_name": "Rhbdd1", "organism": "Rat", "refseq_name": "rhomboid-related protein 4", "refseq_ac": "NP_001020062", "gene_names_uniprotkb": "Rhbdd1; Rhbdl4", "gene_names_refseq": "RGD1306477; RRP4; Rhbdd1; rRHBDD1", "protein_names_uniprotkb": "Rhomboid-related protein 4; 3.4.21.105; RRP4; Rhomboid domain-containing protein 1; Rhomboid-like protein 4; rRHBDD1", "protein_names_refseq": "rhomboid domain-containing protein 1; rhomboid-like protein 4; rhomboid-related protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:316557)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19358743;29393594", "class_list": "", "function": "Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol;GO:0043066 negative regulation of apoptotic process;GO:0043687 post-translational protein modification;GO:0006915 apoptotic process;GO:0010954 positive regulation of protein processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V8F3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8F4-1", "uniprot_id": "RABEK_RAT", "mass": 40152.0, "length": 372, "protein_name": "Rab9 effector protein with kelch motifs", "gene_name": "Rabepk", "organism": "Rat", "refseq_name": "rab9 effector protein with kelch motifs", "refseq_ac": "NP_001020042", "gene_names_uniprotkb": "Rabepk", "gene_names_refseq": "Rabepk", "protein_names_uniprotkb": "Rab9 effector protein with kelch motifs", "protein_names_refseq": "Rab9 effector p40; rab9 effector protein with kelch motifs", "tax_id": 10116, "disease": "", "pathway": " (rno:296649); (R-RNO-6811440)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Rab9 effector required for endosome to trans-Golgi network (TGN) transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0010008 endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8F5-1", "uniprot_id": "TADA3_RAT", "mass": 48898.0, "length": 432, "protein_name": "Transcriptional adapter 3", "gene_name": "Tada3", "organism": "Rat", "refseq_name": "transcriptional adapter 3", "refseq_ac": "NP_001020905", "gene_names_uniprotkb": "Tada3; Ada3; Tada3l", "gene_names_refseq": "Tada3l; Tada3", "protein_names_uniprotkb": "Transcriptional adapter 3; ADA3 homolog; ADA3-like protein; Transcriptional adapter 3-like", "protein_names_refseq": "ADA3 homolog; ADA3-like protein; transcriptional adapter 3", "tax_id": 10116, "disease": "", "pathway": " (rno:362414); (R-RNO-5689880); (R-RNO-9772755)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000124 SAGA complex;GO:0072686 mitotic spindle", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8G4-1", "uniprot_id": "DNAI4_RAT", "mass": 90198.0, "length": 803, "protein_name": "Dynein axonemal intermediate chain 4", "gene_name": "Dnai4", "organism": "Rat", "refseq_name": "dynein axonemal intermediate chain 4", "refseq_ac": "NP_001019957", "gene_names_uniprotkb": "Dnai4; Wdr78", "gene_names_refseq": "Dnai4; RGD1311027; Wdr78", "protein_names_uniprotkb": "Dynein axonemal intermediate chain 4; WD repeat-containing protein 78", "protein_names_refseq": "WD repeat domain 78; WD repeat-containing protein 78; dynein axonemal intermediate chain 4; dynein intermediate chain 4, axonemal", "tax_id": 10116, "disease": "ciliopathy (Disease Ontology:DOID:0060340)", "pathway": " (rno:313417)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5XIP5", "ec_number_list": "", "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0031514 motile cilium;GO:0005930 axoneme;GO:0005858 axonemal dynein complex;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation;GO:0003341 cilium movement;GO:0070286 axonemal dynein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8G4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8G5-1", "uniprot_id": "SEP12_RAT", "mass": 40799.0, "length": 356, "protein_name": "Septin-12", "gene_name": "Septin12", "organism": "Rat", "refseq_name": "septin-12", "refseq_ac": "NP_001094335", "gene_names_uniprotkb": "Septin12; Sept12", "gene_names_refseq": "Sept12; Septin12", "protein_names_uniprotkb": "Septin-12", "protein_names_refseq": "septin-12", "tax_id": 10116, "disease": "spermatogenic failure 10 (Disease Ontology:DOID:0070178)", "pathway": " (rno:363542)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17685441", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (By similarity). Facilitates the formation of Septin filament structures with SEPTIN7, SEPTIN6, SEPTIN2 and SEPTIN4 at the sperm annulus (By similarity). Correct formation of the annulus is required for development of normal structural morphology and motility of the sperm during steps 13 to 16 of spermiogenesis (By similarity). Essential component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during spermiogenesis (By similarity). Required for PLCZ1 localization at the sperm acrosome during spermiogenesis (By similarity). May also play a role in the initiation of calcium oscillations in embryos (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study describes Sept12, a novel septin, identified in a yeast two hybrid screen using Sept5 as the bait; Sept12 protein levels rise upon sexual maturity and the Sept12 protein colocalizes with the annulus in isolated mature spermatozoa., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0005819 spindle;GO:0048471 perinuclear region of cytoplasm;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8I3-1", "uniprot_id": "TENS4_RAT", "mass": 77279.0, "length": 718, "protein_name": "Tensin-4", "gene_name": "Tns4", "organism": "Rat", "refseq_name": "tensin-4 precursor", "refseq_ac": "NP_001020052", "gene_names_uniprotkb": "Tns4", "gene_names_refseq": "RGD1310402; Tns4", "protein_names_uniprotkb": "Tensin-4", "protein_names_refseq": "C-terminal tensin-like; tensin-4 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:303517); (R-RNO-8875513)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3V8W6", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005925 focal adhesion", "go_biological_process": "GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8J7-1", "uniprot_id": "SPIN1_RAT", "mass": 29629.0, "length": 262, "protein_name": "Spindlin-1", "gene_name": "LOC120100784; Spin1", "organism": "Rat", "refseq_name": "spindlin-1 isoform 1", "refseq_ac": "NP_001019967", "gene_names_uniprotkb": "LOC120100784; Spin1; LOC120097510; Spin1; Spin", "gene_names_refseq": "Spin1; Spin", "protein_names_uniprotkb": "Spindlin-1; Spindlin1", "protein_names_refseq": "spindlin-1 isoform 1; spindlin1", "tax_id": 10116, "disease": "", "pathway": " (rno:361217)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31378911", "class_list": "", "function": "Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis. Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (By similarity). Overexpression induces metaphase arrest and chromosomal instability (By similarity). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (By similarity). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MicroRNA-489 promotes cardiomyocyte apoptosis induced by myocardial ischemia-reperfusion injury through inhibiting SPIN1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0140566 histone reader activity;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0016055 Wnt signaling pathway;GO:0009303 rRNA transcription;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8J7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4VHE7-1", "uniprot_id": "T2R38_RAT", "mass": 37233.0, "length": 331, "protein_name": "Taste receptor type 2 member 38", "gene_name": "Tas2r38", "organism": "Rat", "refseq_name": "taste receptor type 2 member 38", "refseq_ac": "NP_001019856", "gene_names_uniprotkb": "Tas2r38; T2r38; Tas2r138; Tas2r26", "gene_names_refseq": "T2R38; Tas2r138; Tas2r38", "protein_names_uniprotkb": "Taste receptor type 2 member 38; T2R26; T2R38; Taste receptor type 2 member 138; Taste receptor type 2 member 26", "protein_names_refseq": "T2R26; taste receptor type 2 member 26; taste receptor type 2 member 38; taste receptor, type 2, member 38", "tax_id": 10116, "disease": "", "pathway": " (rno:500091); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15886333", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q67ES4", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4VHE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q505J3-1", "uniprot_id": "WSCD1_RAT", "mass": 64789.0, "length": 572, "protein_name": "Sialate:O-sulfotransferase 1", "gene_name": "Wscd1", "organism": "Rat", "refseq_name": "sialate:O-sulfotransferase 1", "refseq_ac": "NP_001019405", "gene_names_uniprotkb": "Wscd1", "gene_names_refseq": "RGD1308212; Wscd1", "protein_names_uniprotkb": "Sialate:O-sulfotransferase 1; WSC domain-containing protein 1", "protein_names_refseq": "WSC domain containing 1; WSC domain-containing protein 1; sialate:O-sulfotransferase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:287466)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. Displays selectivity toward glycolipids such as GM1 gangliosides., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q505J3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q561K4-1", "uniprot_id": "CCD32_RAT", "mass": 20018.0, "length": 179, "protein_name": "Coiled-coil domain-containing protein 32", "gene_name": "Ccdc32", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 32", "refseq_ac": "NP_001019416", "gene_names_uniprotkb": "Ccdc32", "gene_names_refseq": "Ccdc32; Gm631", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 32", "protein_names_refseq": "coiled-coil domain-containing protein 32; uncharacterized protein C15orf57 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:296081)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates clathrin-mediated endocytsois of cargos such as transferrin probably through the association and modulation of adaptor protein complex 2 (AP-2) (By similarity). Has a role in ciliogenesis (By similarity). Required for proper cephalic and left/right axis development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005905 clathrin-coated pit", "go_biological_process": "GO:2000369 regulation of clathrin-dependent endocytosis;GO:0044782 cilium organization;GO:0060322 head development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q561K4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q566C5-1", "uniprot_id": "RASF4_RAT", "mass": 37125.0, "length": 322, "protein_name": "Ras association domain-containing protein 4", "gene_name": "Rassf4", "organism": "Rat", "refseq_name": "ras association domain-containing protein 4", "refseq_ac": "NP_001019446", "gene_names_uniprotkb": "Rassf4", "gene_names_refseq": "Rassf4", "protein_names_uniprotkb": "Ras association domain-containing protein 4", "protein_names_refseq": "Ras association (RalGDS/AF-6) domain family 4; Ras association (RalGDS/AF-6) domain family member 4; ras association domain-containing protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:362423)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q566C5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q568Y3-1", "uniprot_id": "RN185_RAT", "mass": 20493.0, "length": 192, "protein_name": "E3 ubiquitin-protein ligase RNF185", "gene_name": "Rnf185", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF185", "refseq_ac": "NP_001019442", "gene_names_uniprotkb": "Rnf185", "gene_names_refseq": "Rnf185", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF185; 2.3.2.27; RING finger protein 185", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF185; RING-type E3 ubiquitin transferase RNF185", "tax_id": 10116, "disease": "", "pathway": " (rno:360967); (R-RNO-382556); (R-RNO-9931269)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6;3.6.4.6;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0061630 ubiquitin protein ligase activity;GO:0043130 ubiquitin binding;GO:0044390 ubiquitin-like protein conjugating enzyme binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006914 autophagy;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q568Y3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BIV7-1", "uniprot_id": "SPRN_RAT", "mass": 14712.0, "length": 147, "protein_name": "Shadow of prion protein", "gene_name": "Sprn", "organism": "Rat", "refseq_name": "shadow of prion protein isoform 1 precursor", "refseq_ac": "NP_001027015", "gene_names_uniprotkb": "Sprn", "gene_names_refseq": "Sprn", "protein_names_uniprotkb": "Shadow of prion protein; Protein shadoo", "protein_names_refseq": "Shadoo; protein shadoo; shadow of prion protein homolog; shadow of prion protein isoform 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:541462); (R-RNO-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "14527721", "class_list": "", "function": "Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BIV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BJN9-1", "uniprot_id": "RPRM_RAT", "mass": 11792.0, "length": 109, "protein_name": "Protein reprimo", "gene_name": "Rprm", "organism": "Rat", "refseq_name": "protein reprimo", "refseq_ac": "NP_001037741", "gene_names_uniprotkb": "Rprm", "gene_names_refseq": "Rprm", "protein_names_uniprotkb": "Protein reprimo", "protein_names_refseq": "candidate mediator of the p53-dependent G2 arrest; protein reprimo; reprimo, TP53 dependent G2 arrest mediator candidate", "tax_id": 10116, "disease": "", "pathway": " (rno:680110)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007346 regulation of mitotic cell cycle;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BJP5-1", "uniprot_id": "TM230_RAT", "mass": 13204.0, "length": 120, "protein_name": "Transmembrane protein 230", "gene_name": "Tmem230", "organism": "Rat", "refseq_name": "transmembrane protein 230", "refseq_ac": "NP_001041508", "gene_names_uniprotkb": "Tmem230", "gene_names_refseq": "RGD1307399; Tmem230", "protein_names_uniprotkb": "Transmembrane protein 230", "protein_names_refseq": "HSPC274 protein; UPF0414 transmembrane protein C20orf30 homolog; transmembrane protein 230", "tax_id": 10116, "disease": "", "pathway": " (rno:681315)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;27270108", "class_list": "", "function": "Involved in trafficking and recycling of synaptic vesicles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGK9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0055037 recycling endosome;GO:0012505 endomembrane system;GO:0005770 late endosome;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0048489 synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5BJP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BJT2-1", "uniprot_id": "UBL3_RAT", "mass": 13180.0, "length": 117, "protein_name": "Ubiquitin-like protein 3", "gene_name": "Ubl3", "organism": "Rat", "refseq_name": "ubiquitin-like protein 3", "refseq_ac": "NP_001015030", "gene_names_uniprotkb": "Ubl3", "gene_names_refseq": "Ubl3", "protein_names_uniprotkb": "Ubiquitin-like protein 3; MUB; Membrane-anchored ubiquitin-fold protein", "protein_names_refseq": "MUB; membrane-anchored ubiquitin-fold protein; ubiquitin-like protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:363869)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BJT7-1", "uniprot_id": "CCD93_RAT", "mass": 72636.0, "length": 629, "protein_name": "Coiled-coil domain-containing protein 93", "gene_name": "Ccdc93", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 93", "refseq_ac": "NP_001020168", "gene_names_uniprotkb": "Ccdc93", "gene_names_refseq": "Ccdc93", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 93", "protein_names_refseq": "coiled-coil domain containing 93; coiled-coil domain-containing protein 93", "tax_id": 10116, "disease": "", "pathway": " (rno:304743)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (By similarity). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (By similarity). The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (By similarity). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006631 fatty acid metabolic process;GO:0015031 protein transport;GO:1905144 response to acetylcholine;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BJX1-1", "uniprot_id": "RM41_RAT", "mass": 15193.0, "length": 134, "protein_name": "Large ribosomal subunit protein mL41", "gene_name": "Mrpl41", "organism": "Rat", "refseq_name": "large ribosomal subunit protein mL41 precursor", "refseq_ac": "NP_001013444", "gene_names_uniprotkb": "Mrpl41", "gene_names_refseq": "Mrpl41", "protein_names_uniprotkb": "Large ribosomal subunit protein mL41; 39S ribosomal protein L41, mitochondrial; L41mt; MRP-L41", "protein_names_refseq": "39S ribosomal protein L41, mitochondrial; L41mt; MRP-L41; large ribosomal subunit protein mL41 precursor; large ribosomal subunit protein mL41", "tax_id": 10116, "disease": "", "pathway": " (rno:296551); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9857009", "class_list": "", "function": "Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006915 apoptotic process;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BK07-1", "uniprot_id": "CCD43_RAT", "mass": 25061.0, "length": 222, "protein_name": "Coiled-coil domain-containing protein 43", "gene_name": "Ccdc43", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 43", "refseq_ac": "NP_001094198", "gene_names_uniprotkb": "Ccdc43", "gene_names_refseq": "Ccdc43; RGD1311929", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 43", "protein_names_refseq": "coiled-coil domain-containing protein 43", "tax_id": 10116, "disease": "", "pathway": " (rno:360637)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BK46-1", "uniprot_id": "RNH1_RAT", "mass": 31773.0, "length": 285, "protein_name": "Ribonuclease H1", "gene_name": "Rnaseh1", "organism": "Rat", "refseq_name": "ribonuclease H1 isoform 1 precursor", "refseq_ac": "NP_001013115", "gene_names_uniprotkb": "Rnaseh1", "gene_names_refseq": "Rnaseh1", "protein_names_uniprotkb": "Ribonuclease H1; 3.1.26.4; RNase H1", "protein_names_refseq": "RNase H1; ribonuclease H1 isoform 1 precursor", "tax_id": 10116, "disease": "autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (Disease Ontology:DOID:0111515)", "pathway": " (rno:298933)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II., [UniProtKB, UniProtKB]; This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which encodes 7aa in rat. [provided by RefSeq, Nov 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0004523 RNA-DNA hybrid ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006264 mitochondrial DNA replication;GO:0043137 DNA replication, removal of RNA primer", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BK49-1", "uniprot_id": "TACT_RAT", "mass": 67228.0, "length": 603, "protein_name": "T-cell surface protein tactile", "gene_name": "Cd96", "organism": "Rat", "refseq_name": "T-cell surface protein tactile precursor", "refseq_ac": "NP_001020203", "gene_names_uniprotkb": "Cd96", "gene_names_refseq": "Cd96", "protein_names_uniprotkb": "T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein", "protein_names_refseq": "CD96 antigen; T-cell surface protein tactile precursor; T-cell surface protein tactile; cell surface antigen CD96; t cell-activated increased late expression protein", "tax_id": 10116, "disease": "C syndrome (Disease Ontology:DOID:0111581)", "pathway": " (rno:498079); (R-RNO-198933)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity)., [UniProtKB]", "predicted_glycosites": 17, "predicted_n_glycosites": 16, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0032689 negative regulation of type II interferon production;GO:0007160 cell-matrix adhesion;GO:0002728 negative regulation of natural killer cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BK83-1", "uniprot_id": "T106A_RAT", "mass": 29136.0, "length": 261, "protein_name": "Transmembrane protein 106A", "gene_name": "Tmem106a", "organism": "Rat", "refseq_name": "transmembrane protein 106A", "refseq_ac": "NP_001020138", "gene_names_uniprotkb": "Tmem106a", "gene_names_refseq": "RGD1309043; Tmem106a", "protein_names_uniprotkb": "Transmembrane protein 106A", "protein_names_refseq": "transmembrane protein 106A", "tax_id": 10116, "disease": "", "pathway": " (rno:287722)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043410 positive regulation of MAPK cascade;GO:0045087 innate immune response;GO:0009101 glycoprotein biosynthetic process;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5EB73-1", "uniprot_id": "PGAP4_RAT", "mass": 46592.0, "length": 403, "protein_name": "GPI-N-acetylgalactosamine transferase PGAP4", "gene_name": "Pgap4", "organism": "Rat", "refseq_name": "GPI-N-acetylgalactosamine transferase PGAP4", "refseq_ac": "NP_001014212", "gene_names_uniprotkb": "Pgap4; Tmem246", "gene_names_refseq": "Pgap4; RGD1307218; Tmem246", "protein_names_uniprotkb": "GPI-N-acetylgalactosamine transferase PGAP4; 2.4.1.-; GPI-GalNAc transferase PGAP4; Post-GPI attachment to proteins GalNAc transferase 4; Post-GPI attachment to proteins factor 4; Transmembrane protein 246", "protein_names_refseq": "GPI-GalNAc transferase PGAP4; GPI-N-acetylgalactosamine transferase PGAP4; post-GPI attachment to proteins factor 4; transmembrane protein 246; transmembrane protein C9orf125 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:362518)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Golgi-resident glycosylphosphatidylinositol (GPI)-N-acetylgalactosamine transferase that catalyzes the N-acetyl-beta-D-galactosamine transfer from an UDP-N-acetyl-alpha-D-galactosamine to the 4-OH-position of first mannose of the glycosylphosphatidylinositol (GPI) of a GPI-anchored protein (GPI-AP). This modification occurs after the fatty acid remodeling step of the GPI-anchor maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5EB73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5EB77-1", "uniprot_id": "RAB18_RAT", "mass": 22976.0, "length": 206, "protein_name": "Ras-related protein Rab-18", "gene_name": "Rab18", "organism": "Rat", "refseq_name": "ras-related protein Rab-18", "refseq_ac": "NP_001012486", "gene_names_uniprotkb": "Rab18", "gene_names_refseq": "Rab18", "protein_names_uniprotkb": "Ras-related protein Rab-18; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-18", "tax_id": 10116, "disease": "Warburg micro syndrome 3 (Disease Ontology:DOID:0110718)", "pathway": " (rno:307039); (R-RNO-6798695); (R-RNO-6811436); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "17488286;21112318;23333653;30721447", "class_list": "", "function": "Data suggest that overexpression of Rab18 in its GDP-bound state favors peroxisome proliferation in hepatocytes; Rab18 (as well as Rab6, Rab10, and Rab14) localizes to the peroxisomal compartment., [RefSeq, PubMed]; In neuroendocrine cells, Rab18 acts as a negative regulator of secretory activity, likely by impairing secretory granule transport, [RefSeq, PubMed]; Overexpression of brain RAB18 in alloxan diabetes leads to uneven distribution and function of intracellular-vesicular transport causing accumulation of protein inside the cell, this results in neurological disorder., [RefSeq, PubMed]; The functions of RAB18 and RAB7 in lysosomal and autophagic activities may constitute an overlapping mechanism underlying Warburg micro syndrome and Charcot-Marie-Tooth Neuropathy Type 2B pathogenesis in the nervous system., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Also required for maintaining endoplasmic reticulum structure (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.4.1.-;2.7.11.1;3.6.5.5;3.6.1.5;3.1.3.48;3.4.24.11;3.4.11.-;3.4.11.2;2.5.1.60;2.4.1.41;3.6.1.-;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0006886 intracellular protein transport;GO:0051170 import into nucleus;GO:0007420 brain development;GO:0034389 lipid droplet organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5EB77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVL6-1", "uniprot_id": "TSN13_RAT", "mass": 22259.0, "length": 204, "protein_name": "Tetraspanin-13", "gene_name": "Tspan13", "organism": "Rat", "refseq_name": "tetraspanin-13", "refseq_ac": "NP_001013262", "gene_names_uniprotkb": "Tspan13; Tm4sf13", "gene_names_refseq": "Tm4sf13; Tspan13", "protein_names_uniprotkb": "Tetraspanin-13; Transmembrane 4 superfamily member 13; Tspan-13", "protein_names_refseq": "tetraspanin-13; transmembrane 4 superfamily member 13; tspan-13", "tax_id": 10116, "disease": "", "pathway": " (rno:366602)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1903169 regulation of calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5GAL7-1", "uniprot_id": "RNS13_RAT", "mass": 17445.0, "length": 153, "protein_name": "Probable inactive ribonuclease-like protein 13", "gene_name": "Rnase13; Tppp2", "organism": "Rat", "refseq_name": "probable inactive ribonuclease-like protein 13 precursor", "refseq_ac": "NP_001012231", "gene_names_uniprotkb": "Rnase13; Tppp2; Tppp2", "gene_names_refseq": "Rnase13", "protein_names_uniprotkb": "Probable inactive ribonuclease-like protein 13", "protein_names_refseq": "probable inactive ribonuclease-like protein 13 precursor; probable inactive ribonuclease-like protein 13; ribonuclease 13; ribonuclease, RNase A family, 13 (non-active); ribonuclease-like protein 13", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:497194)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15676279", "class_list": "", "function": "Does not exhibit any ribonuclease activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0036126 sperm flagellum", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0046785 microtubule polymerization;GO:0001578 microtubule bundle formation;GO:0032273 positive regulation of protein polymerization;GO:1901317 regulation of flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5GAL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5GAL8-1", "uniprot_id": "RNS12_RAT", "mass": 16976.0, "length": 145, "protein_name": "Probable inactive ribonuclease-like protein 12", "gene_name": "Rnase12", "organism": "Rat", "refseq_name": "probable inactive ribonuclease-like protein 12 precursor", "refseq_ac": "NP_001012209", "gene_names_uniprotkb": "Rnase12", "gene_names_refseq": "RGD1307829; Rai1; Rnase12", "protein_names_uniprotkb": "Probable inactive ribonuclease-like protein 12", "protein_names_refseq": "probable inactive ribonuclease-like protein 12 precursor; probable inactive ribonuclease-like protein 12; ribonuclease 12; ribonuclease A i1; ribonuclease, RNase A family, 12 (non-active); ribonuclease-like protein 12", "tax_id": 10116, "disease": "", "pathway": " (rno:364302)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15676279", "class_list": "", "function": "Does not exhibit any ribonuclease activity., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5GAL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5GAM0-1", "uniprot_id": "RNS10_RAT", "mass": 23531.0, "length": 212, "protein_name": "Inactive ribonuclease-like protein 10", "gene_name": "Rnase10", "organism": "Rat", "refseq_name": "inactive ribonuclease-like protein 10 precursor", "refseq_ac": "NP_001012485", "gene_names_uniprotkb": "Rnase10", "gene_names_refseq": "RGD1310415; Rah1; Rnase10", "protein_names_uniprotkb": "Inactive ribonuclease-like protein 10; Protein Train A", "protein_names_refseq": "inactive ribonuclease-like protein 10 precursor; inactive ribonuclease-like protein 10; protein Train A; ribonuclease 10; ribonuclease A h1; ribonuclease, RNase A family, 10 (non-active); ribonuclease-like protein 10", "tax_id": 10116, "disease": "", "pathway": " (rno:305840)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14561640;15676279", "class_list": "", "function": "Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0050830 defense response to Gram-positive bacterium;GO:0007338 single fertilization;GO:0008584 male gonad development;GO:0072520 seminiferous tubule development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5GAM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5GH56-1", "uniprot_id": "XKR7_RAT", "mass": 64338.0, "length": 580, "protein_name": "XK-related protein 7", "gene_name": "Xkr7", "organism": "Rat", "refseq_name": "XK-related protein 7", "refseq_ac": "NP_001012092", "gene_names_uniprotkb": "Xkr7; Xrg7", "gene_names_refseq": "Xkr7", "protein_names_uniprotkb": "XK-related protein 7", "protein_names_refseq": "X Kell blood group precursor related family member 7 homolog; X-linked Kx blood group related 7; XK, Kell blood group complex subunit-related family, member 7; XK-related protein 7", "tax_id": 10116, "disease": "", "pathway": " (rno:311549)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0043652 engulfment of apoptotic cell;GO:0070782 phosphatidylserine exposure on apoptotic cell surface;GO:1902742 apoptotic process involved in development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5GH56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5HZA9-1", "uniprot_id": "T126A_RAT", "mass": 21657.0, "length": 196, "protein_name": "Transmembrane protein 126A", "gene_name": "Tmem126a", "organism": "Rat", "refseq_name": "transmembrane protein 126A", "refseq_ac": "NP_001011557", "gene_names_uniprotkb": "Tmem126a", "gene_names_refseq": "RGD1305677; Tmem126a", "protein_names_uniprotkb": "Transmembrane protein 126A", "protein_names_refseq": "transmembrane protein 126A", "tax_id": 10116, "disease": "optic atrophy 7 (Disease Ontology:DOID:0111437)", "pathway": " (rno:293113)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26446791;27213235", "class_list": "", "function": "Protein required for the cotranslational protein quality control in the inner membrane of the mitochondria. Associates with newly synthesized polypeptides and may act as a chaperone that cooperates with OXA1L for the insertion of newly synthesized mitochondrial proteins into the inner membrane. Required for the assembly of the ND4 module of mitochondrial complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0021554 optic nerve development;GO:0034142 toll-like receptor 4 signaling pathway;GO:0032979 protein insertion into mitochondrial inner membrane from matrix;GO:0141164 mitochondrial protein quality control", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5HZA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5HZE2-1", "uniprot_id": "TACAN_RAT", "mass": 40657.0, "length": 343, "protein_name": "Transmembrane protein 120A", "gene_name": "Tmem120a", "organism": "Rat", "refseq_name": "transmembrane protein 120A", "refseq_ac": "NP_001010945", "gene_names_uniprotkb": "Tmem120a", "gene_names_refseq": "RGD1311474; Tmem120a; Tmpit", "protein_names_uniprotkb": "Transmembrane protein 120A; Ion channel TACAN", "protein_names_refseq": "ion channel TACAN; transmembrane protein 120A; transmembrane protein induced by tumor necrosis factor alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:288591)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation. May function as a potential ion channel involved in sensing mechanical stimuli. Mediates the mechanosensitivity of the PKD2-TMEM120A channel complex through direct physical interaction (By similarity). TMEM120A seems to affect mechanosensation by inhibiting PIEZO2 channels, possibly by altering cellular lipid content (By similarity). TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism. Additionally, implicated in innate immune response against Zika virus. Acts as a key activator of the antiviral signaling involving STING1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0005216 monoatomic ion channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization;GO:0034220 monoatomic ion transmembrane transport;GO:0045444 fat cell differentiation;GO:0050966 detection of mechanical stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5HZE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I0E7-1", "uniprot_id": "TMED9_RAT", "mass": 27028.0, "length": 235, "protein_name": "Transmembrane emp24 domain-containing protein 9", "gene_name": "Tmed9", "organism": "Rat", "refseq_name": "transmembrane emp24 domain-containing protein 9 precursor", "refseq_ac": "NP_001009703", "gene_names_uniprotkb": "Tmed9", "gene_names_refseq": "RGD1307627; Tmed9", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 9; p24 family protein alpha-2; p24alpha2", "protein_names_refseq": "p24 family protein alpha-2; p24alpha2; transmembrane emp24 domain-containing protein 9 precursor; transmembrane emp24 domain-containing protein 9; transmembrane emp24 protein transport domain containing 9", "tax_id": 10116, "disease": "", "pathway": " (rno:361207); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21545355;29393594;9472029", "class_list": "", "function": "Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0048205 COPI coating of Golgi vesicle;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5I0E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I0H4-1", "uniprot_id": "TMCO1_RAT", "mass": 21175.0, "length": 188, "protein_name": "Calcium load-activated calcium channel", "gene_name": "Tmco1", "organism": "Rat", "refseq_name": "calcium load-activated calcium channel", "refseq_ac": "NP_001009631", "gene_names_uniprotkb": "Tmco1", "gene_names_refseq": "Tmco1", "protein_names_uniprotkb": "Calcium load-activated calcium channel; CLAC channel; GEL complex subunit TMCO1; Meg-2-like protein; Transmembrane and coiled-coil domain-containing protein 1", "protein_names_refseq": "CLAC channel; GEL complex subunit TMCO1; calcium load-activated calcium channel; meg-2-like protein; putative membrane protein; transmembrane and coiled-coil domain-containing protein 1; transmembrane and coiled-coil domains protein 1", "tax_id": 10116, "disease": "craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome (Disease Ontology:DOID:0081072); craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 1 (Disease Ontology:DOID:0081124)", "pathway": " (rno:289196)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoplasmic reticulum (ER) calcium-selective channel preventing intracellular Ca2(+) stores from overfilling and maintaining calcium homeostasis in the ER. In response to endoplasmic reticulum (ER) Ca2(+) overloading, assembles into a homotetramer, forming a functional calcium-selective channel facilitating Ca2(+) release. Mediates ER Ca2(+) homeostasis in osteoblasts and plays a key role in bone formation, via the CaMKII-HDAC4-RUNX2 signaling axis. Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q71DI0", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0001503 ossification;GO:0070588 calcium ion transmembrane transport;GO:0006983 ER overload response;GO:0032469 endoplasmic reticulum calcium ion homeostasis;GO:0160063 multi-pass transmembrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I0I5-1", "uniprot_id": "USB1_RAT", "mass": 30475.0, "length": 267, "protein_name": "U6 snRNA phosphodiesterase 1", "gene_name": "Usb1", "organism": "Rat", "refseq_name": "U6 snRNA phosphodiesterase 1", "refseq_ac": "NP_001014035", "gene_names_uniprotkb": "Usb1; USB1", "gene_names_refseq": "RGD1305215; Usb1", "protein_names_uniprotkb": "U6 snRNA phosphodiesterase 1; 3'-5' RNA exonuclease USB1; 4.6.1.-", "protein_names_refseq": "3'-5' RNA exonuclease USB1; U6 snRNA biogenesis 1; U6 snRNA phosphodiesterase 1; UPF0406 protein C16orf57 homolog; putative U6 snRNA phosphodiesterase", "tax_id": 10116, "disease": "ablepharon macrostomia syndrome (Disease Ontology:DOID:0060550); poikiloderma with neutropenia (Disease Ontology:DOID:0060551)", "pathway": " (rno:307643)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.-;4.6.1.-", "go_molecular_function": "GO:0016829 lyase activity;GO:0000175 3'-5'-RNA exonuclease activity;GO:1990838 poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0008380 RNA splicing;GO:0034477 U6 snRNA 3'-end processing;GO:0034472 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0I5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I0K8-1", "uniprot_id": "RT07_RAT", "mass": 28197.0, "length": 242, "protein_name": "Small ribosomal subunit protein uS7m", "gene_name": "Mrps7", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS7m", "refseq_ac": "NP_001093941", "gene_names_uniprotkb": "Mrps7", "gene_names_refseq": "Mrps7", "protein_names_uniprotkb": "Small ribosomal subunit protein uS7m; 28S ribosomal protein S7, mitochondrial; MRP-S7; S7mt", "protein_names_refseq": "28S ribosomal protein S7, mitochondrial; MRP-S7; S7mt; mitchondrial ribosomal protein S7; small ribosomal subunit protein uS7m", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 34 (Disease Ontology:DOID:0111497)", "pathway": " (rno:113958); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5J3K9-1", "uniprot_id": "V1A14_RAT", "mass": 38487.0, "length": 339, "protein_name": "Vomeronasal type-1 receptor A14", "gene_name": "V1ra14", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "V1ra14", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal type-1 receptor A14", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5J3K9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M7U5-1", "uniprot_id": "RAB19_RAT", "mass": 24446.0, "length": 217, "protein_name": "Ras-related protein Rab-19", "gene_name": "Rab19", "organism": "Rat", "refseq_name": "ras-related protein Rab-19", "refseq_ac": "NP_001019497", "gene_names_uniprotkb": "Rab19", "gene_names_refseq": "Rab19", "protein_names_uniprotkb": "Ras-related protein Rab-19; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-19", "tax_id": 10116, "disease": "", "pathway": " (rno:500088); (R-RNO-8873719)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;2.5.1.60;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7U5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M818-1", "uniprot_id": "RM16_RAT", "mass": 28895.0, "length": 251, "protein_name": "Large ribosomal subunit protein uL16m", "gene_name": "Mrpl16", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL16m precursor", "refseq_ac": "NP_001009647", "gene_names_uniprotkb": "Mrpl16", "gene_names_refseq": "Mrpl16", "protein_names_uniprotkb": "Large ribosomal subunit protein uL16m; 39S ribosomal protein L16, mitochondrial; L16mt; MRP-L16", "protein_names_refseq": "39S ribosomal protein L16, mitochondrial; L16mt; MRP-L16; large ribosomal subunit protein uL16m precursor; large ribosomal subunit protein uL16m", "tax_id": 10116, "disease": "", "pathway": " (rno:293754); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5M818-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M819-1", "uniprot_id": "SERB_RAT", "mass": 24968.0, "length": 225, "protein_name": "Phosphoserine phosphatase", "gene_name": "Psph", "organism": "Rat", "refseq_name": "phosphoserine phosphatase", "refseq_ac": "NP_001009679", "gene_names_uniprotkb": "Psph", "gene_names_refseq": "Psph", "protein_names_uniprotkb": "Phosphoserine phosphatase; 3.1.3.3; O-phosphoserine phosphohydrolase; PSPase; PSP", "protein_names_refseq": "O-phosphoserine phosphohydrolase; PSPase; PSP; phosphoserine phosphatase", "tax_id": 10116, "disease": "PSPH deficiency (Disease Ontology:DOID:0050724); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:304429); (R-RNO-977347)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.3", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0036424 L-phosphoserine phosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0031667 response to nutrient levels;GO:0009612 response to mechanical stimulus;GO:0033574 response to testosterone;GO:0006563 L-serine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M819-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M826-1", "uniprot_id": "TM140_RAT", "mass": 20497.0, "length": 184, "protein_name": "Transmembrane protein 140", "gene_name": "Tmem140", "organism": "Rat", "refseq_name": "transmembrane protein 140", "refseq_ac": "NP_001009709", "gene_names_uniprotkb": "Tmem140", "gene_names_refseq": "Tmem140", "protein_names_uniprotkb": "Transmembrane protein 140", "protein_names_refseq": "transmembrane protein 140", "tax_id": 10116, "disease": "", "pathway": " (rno:362334)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M826-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M862-1", "uniprot_id": "CC134_RAT", "mass": 26437.0, "length": 229, "protein_name": "Coiled-coil domain-containing protein 134", "gene_name": "Ccdc134", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 134 precursor", "refseq_ac": "NP_001019526", "gene_names_uniprotkb": "Ccdc134", "gene_names_refseq": "Ccdc134", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 134", "protein_names_refseq": "coiled-coil domain-containing protein 134 precursor; coiled-coil domain-containing protein 134", "tax_id": 10116, "disease": "osteogenesis imperfecta (Disease Ontology:DOID:12347)", "pathway": " (rno:500909)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21454685", "class_list": "", "function": "Molecular adapter required to prevent protein hyperglycosylation of HSP90B1: during translation, associates with nascent HSP90B1 and the STT3A catalytic component of the OST-A complex and tethers them to a specialized translocon that forms a microenvironment for HSP90B1 folding. In the CCDC134-containing translocon, STT3A associates with the SRT pseudosubstrate motif of HSP90B1, preventing access to facultative glycosylation sites until folding is completed, preventing hyperglycosylation and subsequent degradation of HSP90B1. In extracellular secreted form, promotes proliferation and activation of CD8(+) T-cells, suggesting a cytokine-like function. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. May also localize in the nucleus: enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated histone acetyltransferase activity. Has a critical role in the regulation of osteogenesis and bone development., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:1990402 embryonic liver development;GO:0001525 angiogenesis;GO:0001890 placenta development;GO:0021587 cerebellum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M862-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M877-1", "uniprot_id": "SPSB2_RAT", "mass": 28797.0, "length": 264, "protein_name": "SPRY domain-containing SOCS box protein 2", "gene_name": "Spsb2", "organism": "Rat", "refseq_name": "SPRY domain-containing SOCS box protein 2", "refseq_ac": "NP_001009660", "gene_names_uniprotkb": "Spsb2; Ssb2", "gene_names_refseq": "Grcc9; Spsb2", "protein_names_uniprotkb": "SPRY domain-containing SOCS box protein 2; SSB-2", "protein_names_refseq": "SPRY domain-containing SOCS box protein 2-like; SPRY domain-containing SOCS box protein 2; SPRY domain-containing SOCS box protein SSB-2; SSB-2; gene rich cluster, C9 gene protein", "tax_id": 10116, "disease": "", "pathway": " (rno:297592); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M877-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M882-1", "uniprot_id": "RPP29_RAT", "mass": 25633.0, "length": 221, "protein_name": "Ribonuclease P protein subunit p29", "gene_name": "Pop4", "organism": "Rat", "refseq_name": "ribonuclease P protein subunit p29", "refseq_ac": "NP_001009642", "gene_names_uniprotkb": "Pop4; Rpp29", "gene_names_refseq": "Pop4", "protein_names_uniprotkb": "Ribonuclease P protein subunit p29", "protein_names_refseq": "POP4 (processing of precursor, S. cerevisiae) homolog; POP4 homolog, ribonuclease P/MRP subunit; processing of precursor 4, ribonuclease P/MRP subunit; ribonuclease P protein subunit p29", "tax_id": 10116, "disease": "", "pathway": " (rno:292831)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005730 nucleolus;GO:0000172 ribonuclease MRP complex;GO:0030677 ribonuclease P complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M929-1", "uniprot_id": "RN135_RAT", "mass": 46012.0, "length": 415, "protein_name": "E3 ubiquitin-protein ligase RNF135", "gene_name": "Rnf135", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF135", "refseq_ac": "NP_001012010", "gene_names_uniprotkb": "Rnf135", "gene_names_refseq": "LRRGT00184; MIRO-1; Rhot1; Rnf135", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF135; 2.3.2.27; RING finger protein 135; RING-type E3 ubiquitin transferase RNF135", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF135; RING-type E3 ubiquitin transferase RNF135; ras homolog gene family member T1", "tax_id": 10116, "disease": "", "pathway": " (rno:303350)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response. Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway. Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway. This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway. Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0070534 protein K63-linked ubiquitination;GO:0010994 free ubiquitin chain polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M929-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M936-1", "uniprot_id": "TOR3A_RAT", "mass": 45166.0, "length": 395, "protein_name": "Torsin-3A", "gene_name": "Tor3a", "organism": "Rat", "refseq_name": "torsin-3A precursor", "refseq_ac": "NP_001009683", "gene_names_uniprotkb": "Tor3a", "gene_names_refseq": "Tor3a", "protein_names_uniprotkb": "Torsin-3A; Torsin family 3 member A", "protein_names_refseq": "torsin-3A precursor; torsin-3A", "tax_id": 10116, "disease": "torsion dystonia 1 (Disease Ontology:DOID:0060730); Parkinson's disease (Disease Ontology:DOID:14330); dystonia (Disease Ontology:DOID:543)", "pathway": " (rno:304884)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M936-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M947-1", "uniprot_id": "RRP15_RAT", "mass": 30926.0, "length": 280, "protein_name": "RRP15-like protein", "gene_name": "Rrp15", "organism": "Rat", "refseq_name": "RRP15-like protein", "refseq_ac": "NP_001009702", "gene_names_uniprotkb": "Rrp15", "gene_names_refseq": "RGD1306106; Rrp15", "protein_names_uniprotkb": "RRP15-like protein; Ribosomal RNA-processing protein 15", "protein_names_refseq": "RRP15-like protein; ribosomal RNA-processing protein 15", "tax_id": 10116, "disease": "", "pathway": " (rno:360895)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5M947-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M9F1-1", "uniprot_id": "RBM34_RAT", "mass": 47661.0, "length": 428, "protein_name": "RNA-binding protein 34", "gene_name": "Rbm34", "organism": "Rat", "refseq_name": "RNA-binding protein 34", "refseq_ac": "NP_001014037", "gene_names_uniprotkb": "Rbm34", "gene_names_refseq": "RGD1310161; Rbm34", "protein_names_uniprotkb": "RNA-binding protein 34; RNA-binding motif protein 34", "protein_names_refseq": "RNA-binding protein 34", "tax_id": 10116, "disease": "", "pathway": " (rno:307956)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5M9F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M9G3-1", "uniprot_id": "CAPR1_RAT", "mass": 78121.0, "length": 707, "protein_name": "Caprin-1", "gene_name": "Caprin1", "organism": "Rat", "refseq_name": "caprin-1", "refseq_ac": "NP_001012185", "gene_names_uniprotkb": "Caprin1; Gpiap1; Rng105", "gene_names_refseq": "Caprin1; GPI p137; Gpiap1; rng105", "protein_names_uniprotkb": "Caprin-1; Cytoplasmic activation- and proliferation-associated protein 1; GPI-anchored protein p137; GPI-p137; RNA granule protein 105; p137GPI", "protein_names_refseq": "GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; RNA granule protein 105; caprin-1; cytoplasmic activation- and proliferation-associated protein 1; p137GPI", "tax_id": 10116, "disease": "", "pathway": " (rno:362173)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14565619;15858068;20516077;22673903;38843836", "class_list": "", "function": "RNG105 is a translational repressor in the RNA granules and provide insight into the link between RNG105 dynamics and local translational regulation., [RefSeq, PubMed]; mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:15858068, PubMed:20516077). Plays an essential role in cytoplasmic stress granule formation (By similarity). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (By similarity). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (By similarity). Binds directly and selectively to MYC and CCND2 mRNAs (By similarity). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A9ZSZ9;Q6YF16", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0035591 signaling adaptor activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0030425 dendrite", "go_biological_process": "GO:0007399 nervous system development;GO:0050808 synapse organization;GO:0007416 synapse assembly;GO:0017148 negative regulation of translation;GO:0050775 positive regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5M9G3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NDF0-1", "uniprot_id": "PMGT2_RAT", "mass": 66717.0, "length": 580, "protein_name": "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "gene_name": "Pomgnt2", "organism": "Rat", "refseq_name": "protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "refseq_ac": "NP_001009437", "gene_names_uniprotkb": "Pomgnt2; Ago61; Gtdc2", "gene_names_refseq": "Ago61; Gtdc2; Pomgnt2; RGD1304827", "protein_names_uniprotkb": "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; 2.4.1.312; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2; POMGnT2", "protein_names_refseq": "glycosyltransferase-like domain containing 2; glycosyltransferase-like domain-containing protein 2; glycosyltransferase; protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "tax_id": 10116, "disease": "congenital muscular dystrophy-dystroglycanopathy type A8 (Disease Ontology:DOID:0111231); muscular dystrophy-dystroglycanopathy type C8 (Disease Ontology:DOID:0112382)", "pathway": " (rno:316091); (R-RNO-8932505)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "24090084;38843836", "class_list": "glycogene;glycosyltransferase", "function": "O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.312", "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001764 neuron migration;GO:0006493 protein O-linked glycosylation;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 85, "hit_score": 0.8, "record_id": "Q5NDF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PPI1-1", "uniprot_id": "SRSF9_RAT", "mass": 25498.0, "length": 221, "protein_name": "Serine/arginine-rich splicing factor 9", "gene_name": "Srsf9", "organism": "Rat", "refseq_name": "serine/arginine-rich splicing factor 9", "refseq_ac": "NP_001009255", "gene_names_uniprotkb": "Srsf9; Sfrs9", "gene_names_refseq": "Sfrs9; Srsf9", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 9; Splicing factor, arginine/serine-rich 9", "protein_names_refseq": "serine/arginine-rich splicing factor 9; splicing factor, arginine/serine-rich 9", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054)", "pathway": " (rno:288701); (R-RNO-159236); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "11118435;16641100;22673903", "class_list": "", "function": "Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005634 nucleus", "go_biological_process": "GO:0043279 response to alkaloid;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0009636 response to toxic substance;GO:0048025 negative regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5PPI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PPM7-1", "uniprot_id": "ROM1_RAT", "mass": 37237.0, "length": 351, "protein_name": "Rod outer segment membrane protein 1", "gene_name": "Rom1", "organism": "Rat", "refseq_name": "rod outer segment membrane protein 1", "refseq_ac": "NP_001009690", "gene_names_uniprotkb": "Rom1", "gene_names_refseq": "Rom1", "protein_names_uniprotkb": "Rod outer segment membrane protein 1; ROSP1", "protein_names_refseq": "ROSP1; rod outer segment membrane protein 1", "tax_id": 10116, "disease": "retinitis pigmentosa 7 (Disease Ontology:DOID:0110383)", "pathway": " (rno:309201)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31746385", "class_list": "", "function": "Plays a role in rod outer segment (ROS) morphogenesis (By similarity). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (By similarity). Plays a role in the organization of the ROS and maintenance of ROS disk diameter (By similarity). Involved in the maintenance of the retina outer nuclear layer (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Retinal proteomic evaluation of rats following streptozotocininjection using shotgun proteomics., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0007155 cell adhesion;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PPM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PQL3-1", "uniprot_id": "SPP2B_RAT", "mass": 63737.0, "length": 577, "protein_name": "Signal peptide peptidase-like 2B", "gene_name": "Sppl2b", "organism": "Rat", "refseq_name": "signal peptide peptidase-like 2B isoform 2 precursor", "refseq_ac": "NP_001014222", "gene_names_uniprotkb": "Sppl2b", "gene_names_refseq": "RGD1308556; Sppl2b", "protein_names_uniprotkb": "Signal peptide peptidase-like 2B; 3.4.23.-; SPP-like 2B; SPPL2b", "protein_names_refseq": "presenilin-like protein 1; protein SPP-like 2B; protein SPPL2b; signal peptide peptidase-like 2B isoform 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:362828); (R-RNO-5357905)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.23.-", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0050776 regulation of immune response;GO:0031293 membrane protein intracellular domain proteolysis;GO:0033619 membrane protein proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PQP2-1", "uniprot_id": "RCAS1_RAT", "mass": 24187.0, "length": 213, "protein_name": "Receptor-binding cancer antigen expressed on SiSo cells", "gene_name": "Ebag9", "organism": "Rat", "refseq_name": "receptor-binding cancer antigen expressed on SiSo cells", "refseq_ac": "NP_001009665", "gene_names_uniprotkb": "Ebag9", "gene_names_refseq": "Ebag9", "protein_names_uniprotkb": "Receptor-binding cancer antigen expressed on SiSo cells; Estrogen receptor-binding fragment-associated gene 9 protein", "protein_names_refseq": "estrogen receptor-binding fragment-associated gene 9 protein; receptor-binding cancer antigen expressed on SiSo cells", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometriosis (Disease Ontology:DOID:289); breast ductal carcinoma (Disease Ontology:DOID:3007); invasive ductal carcinoma (Disease Ontology:DOID:3008); uterine cancer (Disease Ontology:DOID:363); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (rno:299864)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16396499;22673903;29393594", "class_list": "", "function": "May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0030141 secretory granule", "go_biological_process": "GO:0006915 apoptotic process;GO:0001913 T cell mediated cytotoxicity;GO:0090717 adaptive immune memory response involving T cells and B cells", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5PQP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QD23-1", "uniprot_id": "TAAR5_RAT", "mass": 38218.0, "length": 337, "protein_name": "Trace amine-associated receptor 5", "gene_name": "Taar5", "organism": "Rat", "refseq_name": "trace amine-associated receptor 5", "refseq_ac": "NP_001009650", "gene_names_uniprotkb": "Taar5", "gene_names_refseq": "Taar5; taR-5", "protein_names_uniprotkb": "Trace amine-associated receptor 5; TaR-5; Trace amine receptor 5", "protein_names_refseq": "trace amine-associated receptor 5", "tax_id": 10116, "disease": "", "pathway": " (rno:294123); (R-RNO-375280)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15718104;22545963;29393594", "class_list": "", "function": "Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male rats, playing a role in social behavior (PubMed:22545963). Also activated by N-methylpiperidine (PubMed:22545963). Trimethylamine is present at high concentration in the urine of male after puberty and acts as an attractant (By similarity). Trimethylamine-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (By similarity). Also required to provide olfactory input into limbic brain areas to regulate emotional behaviors likely via modulation of the serotonin system (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity;GO:1990081 trimethylamine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0050890 cognition;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5QD23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QD24-1", "uniprot_id": "TAAR3_RAT", "mass": 38658.0, "length": 342, "protein_name": "Trace amine-associated receptor 3", "gene_name": "Taar3", "organism": "Rat", "refseq_name": "trace amine-associated receptor 3", "refseq_ac": "NP_001009532", "gene_names_uniprotkb": "Taar3", "gene_names_refseq": "Taar3", "protein_names_uniprotkb": "Trace amine-associated receptor 3; TaR-3; Trace amine receptor 3", "protein_names_refseq": "taR-3; trace amine receptor 3; trace amine-associated receptor 3", "tax_id": 10116, "disease": "", "pathway": " (rno:494319); (R-RNO-375280)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15718104", "class_list": "", "function": "Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This receptor is probably mediated by the G(s)-class of G proteins which activate adenylate cyclase., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5QD24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJK0-1", "uniprot_id": "T106C_RAT", "mass": 28908.0, "length": 260, "protein_name": "Transmembrane protein 106C", "gene_name": "Tmem106c", "organism": "Rat", "refseq_name": "transmembrane protein 106C", "refseq_ac": "NP_001008359", "gene_names_uniprotkb": "Tmem106c", "gene_names_refseq": "RGD1311532; Tmem106c", "protein_names_uniprotkb": "Transmembrane protein 106C", "protein_names_refseq": "transmembrane protein 106C", "tax_id": 10116, "disease": "", "pathway": " (rno:315286)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RK00-1", "uniprot_id": "RM46_RAT", "mass": 31673.0, "length": 277, "protein_name": "Large ribosomal subunit protein mL46", "gene_name": "Mrpl46", "organism": "Rat", "refseq_name": "large ribosomal subunit protein mL46", "refseq_ac": "NP_001013086", "gene_names_uniprotkb": "Mrpl46", "gene_names_refseq": "Mrpl46", "protein_names_uniprotkb": "Large ribosomal subunit protein mL46; 39S ribosomal protein L46, mitochondrial; L46mt; MRP-L46", "protein_names_refseq": "39S ribosomal protein L46, mitochondrial; L46mt; MRP-L46; large ribosomal subunit protein mL46", "tax_id": 10116, "disease": "", "pathway": " (rno:293054); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RK00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RK19-1", "uniprot_id": "SNF8_RAT", "mass": 28884.0, "length": 258, "protein_name": "Vacuolar-sorting protein SNF8", "gene_name": "Snf8", "organism": "Rat", "refseq_name": "vacuolar-sorting protein SNF8", "refseq_ac": "NP_001007805", "gene_names_uniprotkb": "Snf8; Eap30", "gene_names_refseq": "D11moh34; RGD1310144; Snf8", "protein_names_uniprotkb": "Vacuolar-sorting protein SNF8; ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22", "protein_names_refseq": "EAP30 subunit of ELL complex; ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22; SNF8, ESCRT-II complex subunit, homolog; vacuolar-sorting protein SNF8", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:287645); (R-RNO-917729)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10419521;11278625", "class_list": "", "function": "Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs., [UniProtKB, UniProtKB, UniProtKB]; Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs, and plays a role in autophagy. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008289 lipid binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0000814 ESCRT II complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0071985 multivesicular body sorting pathway;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RK19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RKI9-1", "uniprot_id": "RRFM_RAT", "mass": 29152.0, "length": 262, "protein_name": "Ribosome-recycling factor, mitochondrial", "gene_name": "Mrrf", "organism": "Rat", "refseq_name": "ribosome-recycling factor, mitochondrial precursor", "refseq_ac": "NP_001008355", "gene_names_uniprotkb": "Mrrf", "gene_names_refseq": "Mrrf", "protein_names_uniprotkb": "Ribosome-recycling factor, mitochondrial; RRF; Ribosome-releasing factor, mitochondrial", "protein_names_refseq": "RRF; ribosome-recycling factor, mitochondrial precursor; ribosome-recycling factor, mitochondrial; ribosome-releasing factor, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:311903); (R-RNO-5419276)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with GFM2. Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RKI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RLM2-1", "uniprot_id": "S22A7_RAT", "mass": 58654.0, "length": 535, "protein_name": "Solute carrier family 22 member 7", "gene_name": "Slc22a7", "organism": "Rat", "refseq_name": "solute carrier family 22 member 7", "refseq_ac": "NP_445989", "gene_names_uniprotkb": "Slc22a7; Nlt; Oat2", "gene_names_refseq": "Livtr; Oat2; Slc22a7; rOAT2", "protein_names_uniprotkb": "Solute carrier family 22 member 7; Novel liver transporter; Organic anion transporter 2; rOAT2", "protein_names_refseq": "Liver-specific transporter; novel liver transporter; organic anion transporter 2; solute carrier family 22 (organic anion transporter), member 7; solute carrier family 22 member 7", "tax_id": 10116, "disease": "", "pathway": " (rno:89776); (R-RNO-561048); (R-RNO-9749641)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11504818;15900017;16885152;21446918;21454685;25710042;25904762;8056831;9650585", "class_list": "", "function": "Expression of rat OAT2 in HEK (human embryonic kidney)-293 cells stimulates accumulation of the zwitterion trigonelline; subsequently, orotic acid is identified as an excellent and specific substrate of OAT2 from rat., [RefSeq, PubMed]; Functions as a Na(+)-independent bidirectional multispecific transporter (PubMed:11504818, PubMed:15900017, PubMed:21446918, PubMed:9650585). Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively (PubMed:25904762). Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides, and nucleotides with cGMP, 2'deoxyguanosine and GMP being the preferred substrates (By similarity). Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways (By similarity). Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood (PubMed:21446918). Involved in renal secretion and possible reabsorption of creatinine (By similarity). Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (PubMed:11504818, PubMed:9650585). Also transports alpha-ketoglutarate and urate (PubMed:9650585). Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Strongly decreased expression of Oat2 and other transporters in female diabetic ZSF1 rats could possibly impair renal drug excretion, for example, of furosemide, [RefSeq, PubMed]; The findings revealed the important role of OAT2 in renal secretion and possible reabsorption of creatinine and suggested a molecular basis for potential species difference in the transporter handling of creatinine, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63314", "ec_number_list": "", "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0035634 response to stilbenoid;GO:0043252 sodium-independent organic anion transport;GO:0015742 alpha-ketoglutarate transport;GO:0015732 prostaglandin transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5RLM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U203-1", "uniprot_id": "UBE2F_RAT", "mass": 21080.0, "length": 185, "protein_name": "NEDD8-conjugating enzyme UBE2F", "gene_name": "Ube2f", "organism": "Rat", "refseq_name": "NEDD8-conjugating enzyme UBE2F isoform 3", "refseq_ac": "NP_001008382", "gene_names_uniprotkb": "Ube2f", "gene_names_refseq": "RGD1307608; Ube2f", "protein_names_uniprotkb": "NEDD8-conjugating enzyme UBE2F; 2.3.2.34; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; RING-type E3 NEDD8 transferase UBE2F; Ubiquitin-conjugating enzyme E2 F", "protein_names_refseq": "NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme UBE2F isoform 3; NEDD8-conjugating enzyme UBE2F; RING-type E3 NEDD8 transferase UBE2F; ubiquitin-conjugating enzyme E2 F", "tax_id": 10116, "disease": "", "pathway": " (rno:363284); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5 (CUL5). Does not neddylate CUL1, CUL2, CUL3, CUL4A or CUL4B. Mediates neddylation of the CUL9-RBX1 complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.32;2.3.2.31;2.3.2.23;2.3.2.27;2.3.2.34;2.3.2.24;2.3.2.-;2.3.2.25;6.2.1.45;6.2.1.64", "go_molecular_function": "GO:0061654 NEDD8 conjugating enzyme activity;GO:0005524 ATP binding;GO:0019788 NEDD8 transferase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U203-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U208-1", "uniprot_id": "THAP1_RAT", "mass": 24688.0, "length": 210, "protein_name": "THAP domain-containing protein 1", "gene_name": "Thap1", "organism": "Rat", "refseq_name": "THAP domain-containing protein 1", "refseq_ac": "NP_001008341", "gene_names_uniprotkb": "Thap1", "gene_names_refseq": "Thap1", "protein_names_uniprotkb": "THAP domain-containing protein 1", "protein_names_refseq": "THAP domain-containing apoptosis-associated protein 1; THAP domain-containing protein 1", "tax_id": 10116, "disease": "torsion dystonia 6 (Disease Ontology:DOID:0090039)", "pathway": " (rno:306547)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23219941;29393594", "class_list": "", "function": "DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The prominent cytoplasmic and developmentally regulated expression of THAP1 suggests that THAP1 may function as part of a cell surface-nucleus signaling cascade involved in terminal neural differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016605 PML body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U208-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U209-1", "uniprot_id": "RNH2A_RAT", "mass": 33286.0, "length": 301, "protein_name": "Ribonuclease H2 subunit A", "gene_name": "Rnaseh2a; Thsd8", "organism": "Rat", "refseq_name": "ribonuclease H2 subunit A", "refseq_ac": "NP_001013252", "gene_names_uniprotkb": "Rnaseh2a; Thsd8; Rnaseh2a", "gene_names_refseq": "Rnaseh2a", "protein_names_uniprotkb": "Ribonuclease H2 subunit A; 3.1.26.4; RNase H2 subunit A; RNase HI large subunit; Ribonuclease HI large subunit; Ribonuclease HI subunit A", "protein_names_refseq": "RNase H2 subunit A; RNase HI large subunit; ribonuclease H2 subunit A; ribonuclease H2, large subunit; ribonuclease HI large subunit; ribonuclease HI subunit A", "tax_id": 10116, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629)", "pathway": " (rno:364974)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0032299 ribonuclease H2 complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0043137 DNA replication, removal of RNA primer;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U209-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2R4-1", "uniprot_id": "TM10C_RAT", "mass": 48293.0, "length": 414, "protein_name": "tRNA methyltransferase 10 homolog C", "gene_name": "Trmt10c", "organism": "Rat", "refseq_name": "tRNA methyltransferase 10 homolog C precursor", "refseq_ac": "NP_001008338", "gene_names_uniprotkb": "Trmt10c; Mrpp1; Rg9mtd1", "gene_names_refseq": "Rg9mtd1; Trmt10c", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog C; 2.1.1.-; 2.1.1.218; 2.1.1.221; Mitochondrial RNase P protein 1; Mitochondrial ribonuclease P protein 1; RNA (guanine-9-)-methyltransferase domain-containing protein 1; mRNA methyladenosine-N(1)-methyltransferase; tRNA (adenine(9)-N(1))-methyltransferase; tRNA (guanine(9)-N(1))-methyltransferase", "protein_names_refseq": "RNA (guanine-9-) methyltransferase domain containing 1; RNA (guanine-9-)-methyltransferase domain-containing protein 1; mRNA methyladenosine-N(1)-methyltransferase; mitochondrial RNase P protein 1; mitochondrial ribonuclease P protein 1; tRNA (adenine(9)-N(1))-methyltransferase; tRNA (guanine(9)-N(1))-methyltransferase; tRNA methyltransferase 10 homolog C precursor", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 30 (Disease Ontology:DOID:0111471)", "pathway": " (rno:304012)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.221;2.1.1.-;2.1.1.218;2.1.1.220", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity;GO:0160106 tRNA (adenine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0000964 mitochondrial RNA 5'-end processing;GO:0006397 mRNA processing;GO:0070131 positive regulation of mitochondrial translation;GO:0042780 tRNA 3'-end processing;GO:0070901 mitochondrial tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2V9-1", "uniprot_id": "TM39A_RAT", "mass": 56790.0, "length": 497, "protein_name": "Transmembrane protein 39A", "gene_name": "Tmem39a", "organism": "Rat", "refseq_name": "transmembrane protein 39A", "refseq_ac": "NP_001013887", "gene_names_uniprotkb": "Tmem39a", "gene_names_refseq": "RGD1306421; Tmem39a", "protein_names_uniprotkb": "Transmembrane protein 39A", "protein_names_refseq": "transmembrane protein 39A", "tax_id": 10116, "disease": "", "pathway": " (rno:288092)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:1901097 negative regulation of autophagosome maturation;GO:1902902 negative regulation of autophagosome assembly;GO:0006914 autophagy;GO:0045070 positive regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2V9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2W9-1", "uniprot_id": "RNLS_RAT", "mass": 34951.0, "length": 315, "protein_name": "Renalase", "gene_name": "Rnls", "organism": "Rat", "refseq_name": "renalase isoform 2 precursor", "refseq_ac": "NP_001014189", "gene_names_uniprotkb": "Rnls", "gene_names_refseq": "RGD1309804; Rnls", "protein_names_uniprotkb": "Renalase; 1.6.3.5; MAO-C; Monoamine oxidase-C; alpha-NAD(P)H oxidase/anomerase", "protein_names_refseq": "MAO-C; alpha-NAD(P)H oxidase/anomerase; monoamine oxidase-C; renalase isoform 2 precursor", "tax_id": 10116, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); stroke (Disease Ontology:DOID:0051061); interstitial nephritis (Disease Ontology:DOID:1063); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:361751); (R-RNO-196807)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15841207;17565281;18299506;25781495;32053739;37732586;38512760", "class_list": "", "function": "Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+) (By similarity). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis., [UniProtKB, UniProtKB, PubMed, PubMed]; Findings suggest that hypoxia-inducible factor-1alpha (HIF-1alpha) up-regulated renalase directly in hypoxia., [RefSeq, PubMed]; Investigation of the Relationship of Nesfatin-1, Adropin Levels and Claudin-2, Renalase Immunoreactivity with Kidney Function in an Experimental Hypertension Model., [RefSeq, PubMed]; Moderate-intensity exercise increases renalase levels in the blood and skeletal muscle of rats., [RefSeq, PubMed]; Renalase deficiency occurs in salt-sensitive Dahl rats as they develop hypertension[review] Review article, [RefSeq, PubMed]; Renalase regulates renal tubular injury in diabetic nephropathy via the p38MAPK signaling pathway. Erratum:[FASEB J. 2024 Jan;38(1):e23336. doi: 10.1096/fj.202302343. PMID: 38174882], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.6.3.5", "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0051379 epinephrine binding;GO:0016491 oxidoreductase activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H;GO:0070404 NADH binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0002931 response to ischemia;GO:0045776 negative regulation of blood pressure;GO:0060047 heart contraction;GO:0010459 negative regulation of heart rate;GO:0042417 dopamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5U2W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2X6-1", "uniprot_id": "CCD47_RAT", "mass": 55733.0, "length": 483, "protein_name": "PAT complex subunit CCDC47", "gene_name": "Ccdc47", "organism": "Rat", "refseq_name": "PAT complex subunit CCDC47 precursor", "refseq_ac": "NP_001013996", "gene_names_uniprotkb": "Ccdc47", "gene_names_refseq": "Ccdc47; RGD1308813", "protein_names_uniprotkb": "PAT complex subunit CCDC47; Coiled-coil domain-containing protein 47", "protein_names_refseq": "PAT complex component CCDC47; PAT complex subunit CCDC47 precursor; PAT complex subunit CCDC47; coiled-coil domain-containing protein 47", "tax_id": 10116, "disease": "", "pathway": " (rno:303606)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein. Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (By similarity). Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity). Has an essential role in the maintenance of ER organization during embryogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0043022 ribosome binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0030867 rough endoplasmic reticulum membrane;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0009791 post-embryonic development;GO:0036503 ERAD pathway;GO:0055074 calcium ion homeostasis;GO:0006983 ER overload response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2X6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U303-1", "uniprot_id": "TAB2_RAT", "mass": 76328.0, "length": 693, "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "gene_name": "Tab2", "organism": "Rat", "refseq_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "refseq_ac": "NP_001380743", "gene_names_uniprotkb": "Tab2; Map3k7ip2", "gene_names_refseq": "Map3k7ip2; Tab2", "protein_names_uniprotkb": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TGF-beta-activated kinase 1-binding protein 2", "protein_names_refseq": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); congenital heart disease (Disease Ontology:DOID:1682); ovary epithelial cancer (Disease Ontology:DOID:2152); lung non-small cell carcinoma (Disease Ontology:DOID:3908); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:308267); (R-RNO-168638); (R-RNO-202424); (R-RNO-2871837); (R-RNO-445989); (R-RNO-450302); (R-RNO-450321); (R-RNO-5357956); (R-RNO-5607764); (R-RNO-9020702); (R-RNO-937042); (R-RNO-937072); (R-RNO-9645460); (R-RNO-975163)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "36322021", "class_list": "", "function": "Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (By similarity). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MiR-199a target regulates TAB2 to promote the migration of endodermal progenitor cells and inhibit deep vein thrombosis in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007507 heart development;GO:0032496 response to lipopolysaccharide;GO:0045860 positive regulation of protein kinase activity;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U303-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U316-1", "uniprot_id": "RAB35_RAT", "mass": 23025.0, "length": 201, "protein_name": "Ras-related protein Rab-35", "gene_name": "Rab35", "organism": "Rat", "refseq_name": "ras-related protein Rab-35", "refseq_ac": "NP_001013064", "gene_names_uniprotkb": "Rab35", "gene_names_refseq": "Rab35", "protein_names_uniprotkb": "Ras-related protein Rab-35; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-35", "tax_id": 10116, "disease": "", "pathway": " (rno:288700); (R-RNO-8854214); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "19289122;23572513;24600047;24852758;25694427;27535913", "class_list": "", "function": "Rab35 colocalizes with actin filaments and with Cdc42, Rac1 and RhoA, and that Rab35 can activate Cdc42 both in vivo and in vitro, [RefSeq, PubMed]; Rab35 is translocated from recycling endosomes to neurite tips in a late phase of NGF stimulation., [RefSeq, PubMed]; Rab35 regulates the formation of an EHD1-association site on Arf6-positive endosomes by integrating the functions of two distinct Rab35 effectors for successful neurite outgrowth., [RefSeq, PubMed]; Rab35/ACAP2 and cytohesin-2 antagonistically control oligodendrocyte differentiation and myelination through Arf6 regulation., [RefSeq, PubMed]; Showed by knockdown-rescue approaches that neither a centaurin-beta2 binding-deficient Rab35(T76S/T81A) mutant nor a Rab35 binding-deficient centaurin-beta2(N610A/N691A) mutant supported neurite outgrowth of PC12 cells, [RefSeq, PubMed]; The findings of this study demonstrated that the Rab35/ESCRT pathway mediates the use-dependent degradation of a subset of Synaptic Vesicle membrane proteins in mammalian neurons., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;2.5.1.60;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0042470 melanosome;GO:0045171 intercellular bridge;GO:0010008 endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0031175 neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus;GO:0016197 endosomal transport;GO:0036010 protein localization to endosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5U316-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U318-1", "uniprot_id": "PEA15_RAT", "mass": 15040.0, "length": 130, "protein_name": "Astrocytic phosphoprotein PEA-15", "gene_name": "Pea15", "organism": "Rat", "refseq_name": "astrocytic phosphoprotein PEA-15", "refseq_ac": "NP_001013249", "gene_names_uniprotkb": "Pea15", "gene_names_refseq": "Pea15a; Pea15", "protein_names_uniprotkb": "Astrocytic phosphoprotein PEA-15; 15 kDa phosphoprotein enriched in astrocytes", "protein_names_refseq": "15 kDa phosphoprotein enriched in astrocytes; astrocytic phosphoprotein PEA-15; phosphoprotein enriched in astrocytes 15A", "tax_id": 10116, "disease": "", "pathway": " (rno:364052); (R-RNO-112409); (R-RNO-5673001)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "16641100;18541525;21198825;21615786;22067079;22306184;22673903;26615958;28216548;29438777;31257496;31795399", "class_list": "", "function": "A diabetic condition may aggravate brain damage through decreasing expression of PEA-15 and phospho-PEA-15 in ischemic brain injury, [RefSeq, PubMed]; Biomechanical insult dramatically switches PEA-15 phosphorylation and function to uncouple its anti-apoptotic activity, [RefSeq, PubMed]; Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Disruption of the PED/PEA-15-PLD1 molecular interaction enhances insulin sensitivity in skeletal muscle cells, [RefSeq, PubMed]; Overexpression of PEA15 was able to attenuate the neurotoxicity of propofol in rat hippocampal neurons., [RefSeq, PubMed]; The protective effect of melatonin is likely mediated, in part, by inhibition of peroxynitrate-mediated nitrosative stress, which in turn relieves imbalance of mitochondrial HtrA2-PED signaling and endothelial cell death., [RefSeq, PubMed]; The selective manipulation of PEA15 phosphorylations may regulate apoptotic and/or proliferative signals in astrocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78ZC9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0000165 MAPK cascade;GO:0006915 apoptotic process;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0046325 negative regulation of D-glucose import;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q5U318-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XHY7-1", "uniprot_id": "STAM2_RAT", "mass": 57159.0, "length": 523, "protein_name": "Signal transducing adapter molecule 2", "gene_name": "Stam2", "organism": "Rat", "refseq_name": "signal transducing adapter molecule 2", "refseq_ac": "NP_001012085", "gene_names_uniprotkb": "Stam2", "gene_names_refseq": "Stam2", "protein_names_uniprotkb": "Signal transducing adapter molecule 2; STAM-2", "protein_names_refseq": "STAM-2; signal transducing adapter molecule 2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2", "tax_id": 10116, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322)", "pathway": " (rno:311030); (R-RNO-182971); (R-RNO-5689880); (R-RNO-6807004); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-9013420); (R-RNO-917729)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "11062024", "class_list": "", "function": "Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031901 early endosome membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0007165 signal transduction;GO:0015031 protein transport;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XHY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XI28-1", "uniprot_id": "RAVR1_RAT", "mass": 79289.0, "length": 748, "protein_name": "Ribonucleoprotein PTB-binding 1", "gene_name": "Raver1", "organism": "Rat", "refseq_name": "ribonucleoprotein PTB-binding 1", "refseq_ac": "NP_001013961", "gene_names_uniprotkb": "Raver1; Raver1h", "gene_names_refseq": "Raver1h; Raver1", "protein_names_uniprotkb": "Ribonucleoprotein PTB-binding 1; Protein raver-1", "protein_names_refseq": "RAVER1 homolog; protein raver-1; ribonucleoprotein PTB-binding 1", "tax_id": 10116, "disease": "", "pathway": " (rno:298705)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14633994;22673903", "class_list": "", "function": "Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XI28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XI78-1", "uniprot_id": "ODO1_RAT", "mass": 116296.0, "length": 1023, "protein_name": "2-oxoglutarate dehydrogenase complex component E1", "gene_name": "Ogdh", "organism": "Rat", "refseq_name": "2-oxoglutarate dehydrogenase complex component E1 precursor", "refseq_ac": "NP_001017461", "gene_names_uniprotkb": "Ogdh; Ogdhl", "gene_names_refseq": "E1o; OGDH-E1; Ogdh", "protein_names_uniprotkb": "2-oxoglutarate dehydrogenase complex component E1; 1.2.4.2; 2-oxoglutarate dehydrogenase, mitochondrial; Alpha-KGDH-E1; Alpha-ketoglutarate dehydrogenase; E1o; OGDC-E1; OGDH-E1; Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase", "protein_names_refseq": "2-oxoglutarate dehydrogenase E1 component, mitochondrial; 2-oxoglutarate dehydrogenase complex component E1 precursor; 2-oxoglutarate dehydrogenase complex component E1; 2-oxoglutarate dehydrogenase, mitochondrial-like; 2-oxoglutarate dehydrogenase, mitochondrial; OGDC-E1; alpha-KGDH-E1; alpha-ketoglutarate dehydrogenase; oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); oxoglutarate dehydrogenase (lipoamide); thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase", "tax_id": 10116, "disease": "Yoon-Bellen neurodevelopmental syndrome (Disease Ontology:DOID:0070468); oxoglutarate dehydrogenase deficiency (Disease Ontology:DOID:0081326); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:360975); (R-RNO-6783984); (R-RNO-9837999); (R-RNO-9853506)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "18683930;18783430;24515115;26446791;26936970;27213235;28601082;32024885;34502162", "class_list": "", "function": "2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:18783430). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC (Probable). Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (Probable). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids (By similarity). Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate (By similarity). Can also convert 2-keto-4-hydroxyglutarate (KHG) and CoA into malyl-CoA (By similarity). Mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; H2O2 production from Ogdh can be considerable but may previously have been misattributed to complex I., [RefSeq, PubMed]; Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues. Publication Status: Online-Only, [RefSeq, PubMed]; Thiamine Induces Long-Term Changes in Amino Acid Profiles and Activities of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases in Rat Brain, [RefSeq, PubMed]; Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.5;1.3.8.5;6.2.1.4;4.98.1.1;5.6.2.3;2.8.3.5;2.3.1.-;1.2.4.2;2.3.1.41;3.4.21.92;3.5.3.1;3.1.2.2;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.2.-;1.1.1.37;6.4.1.3;7.1.2.2;1.4.1.3;1.2.1.3;2.3.1.37;4.2.1.2;2.3.1.9;2.3.3.10;5.3.3.8;1.1.1.30;3.6.4.10;1.2.4.1;1.1.1.42;5.6.1.7;1.3.8.1;2.3.1.61;2.7.1.23;5.3.3.21;2.7.11.2;2.7.11.-;7.1.1.2;1.2.1.36;1.7.1.-;1.2.1.28;1.8.1.4;2.3.3.1;3.4.21.53;1.1.1.41;4.2.1.3", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding;GO:0030976 thiamine pyrophosphate binding;GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0061034 olfactory bulb mitral cell layer development;GO:0006091 generation of precursor metabolites and energy;GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process;GO:0006104 succinyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q5XI78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIA2-1", "uniprot_id": "SZRD1_RAT", "mass": 16998.0, "length": 152, "protein_name": "SUZ RNA-binding domain-containing", "gene_name": "Szrd1", "organism": "Rat", "refseq_name": "SUZ RNA-binding domain-containing", "refseq_ac": "NP_001108071", "gene_names_uniprotkb": "Szrd1", "gene_names_refseq": "C1orf144; RGD1560286; Szrd1", "protein_names_uniprotkb": "SUZ RNA-binding domain-containing; SUZ domain-containing protein 1", "protein_names_refseq": "SUZ RNA-binding domain-containing; SUZ domain-containing protein 1; UPF0485 protein C1orf144 homolog; putative MAPK activating protein PM20,PM21", "tax_id": 10116, "disease": "", "pathway": " (rno:500575)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIA3-1", "uniprot_id": "TYW4_RAT", "mass": 75533.0, "length": 686, "protein_name": "tRNA wybutosine-synthesizing protein 4", "gene_name": "Lcmt2", "organism": "Rat", "refseq_name": "tRNA wybutosine-synthesizing protein 4", "refseq_ac": "NP_001011956", "gene_names_uniprotkb": "Lcmt2; Tyw4", "gene_names_refseq": "Lcmt2", "protein_names_uniprotkb": "tRNA wybutosine-synthesizing protein 4; 2.1.1.290; 2.3.1.231; Leucine carboxyl methyltransferase 2; tRNA yW-synthesizing protein 4; tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase", "protein_names_refseq": "tRNA wybutosine-synthesizing protein 4 homolog; tRNA wybutosine-synthesizing protein 4; tRNA yW-synthesizing protein 4 homolog; tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)- methoxycarbonyltransferase; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)- methyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:296098)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the final 2 independent reactions, methylation of the alpha-carboxy group of wybutosine-72 to form wybutosine-58, and methoxycarbonylation of alpha-amino group of wybutosine-58 through the fixation of CO(2) to complete wybutosine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.290;2.3.1.231", "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0008270 zinc ion binding;GO:0008168 methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0030488 tRNA methylation;GO:0031591 wybutosine biosynthetic process;GO:0008033 tRNA processing;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6WAY2-1", "uniprot_id": "PLPR1_RAT", "mass": 35887.0, "length": 325, "protein_name": "Phospholipid phosphatase-related protein type 1", "gene_name": "Plppr1", "organism": "Rat", "refseq_name": "phospholipid phosphatase-related protein type 1", "refseq_ac": "NP_958428", "gene_names_uniprotkb": "Plppr1; Lppr1; Prg3", "gene_names_refseq": "Lppr1; Plppr1; Prg-3", "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 1; Inactive 2-lysophosphatidate phosphatase PLPPR1; Lipid phosphate phosphatase-related protein type 1; PRG-3; Plasticity-related gene 3 protein", "protein_names_refseq": "inactive 2-lysophosphatidate phosphatase PLPPR1; lipid phosphate phosphatase-related protein type 1; phospholipid phosphatase-related protein type 1; plasticity related gene 3; plasticity-related gene 3 protein; plasticity-related protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:298062); (R-RNO-419408)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "14750979", "class_list": "", "function": "May play a role in neurite outgrowth and neurogenesis., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; PRG-3 is expressed in brain and shows a specific expression pattern during brain development and is found mostly in neuronal cell layers and expressed at embryonic day 16. In mature brain strongest PRG-3 expression occurs in hippocampus and cerebellum, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6WAY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUC8-1", "uniprot_id": "PLRG1_RAT", "mass": 57189.0, "length": 514, "protein_name": "Pleiotropic regulator 1", "gene_name": "Plrg1", "organism": "Rat", "refseq_name": "pleiotropic regulator 1", "refseq_ac": "NP_068525", "gene_names_uniprotkb": "Plrg1", "gene_names_refseq": "Plrg1", "protein_names_uniprotkb": "Pleiotropic regulator 1", "protein_names_refseq": "pleiotropic regulator 1 homolog; pleiotropic regulator 1", "tax_id": 10116, "disease": "", "pathway": " (rno:60376); (R-RNO-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0031965 nuclear membrane;GO:0001650 fibrillar center", "go_biological_process": "GO:0034504 protein localization to nucleus;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9WUC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYT0-1", "uniprot_id": "QOR_RAT", "mass": 34975.0, "length": 329, "protein_name": "Zeta-crystallin", "gene_name": "Cryz", "organism": "Rat", "refseq_name": "zeta-crystallin", "refseq_ac": "NP_001012183", "gene_names_uniprotkb": "Cryz", "gene_names_refseq": "Cryz", "protein_names_uniprotkb": "Zeta-crystallin; 1.6.5.5; NADPH:quinone reductase; Quinone oxidoreductase", "protein_names_refseq": "NADPH:quinone reductase; crystallin, zeta (quinone reductase); quinone oxidoreductase; zeta-crystallin", "tax_id": 10116, "disease": "", "pathway": " (rno:362061)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12684230", "class_list": "", "function": "Multifunctional crystallin endowed with unrelated mRNA stabilization and enzymatic oxidoreductase activities (PubMed:12684230). Binds (AU)-rich elements (ARE) in the 3'-UTR of target mRNA to enhance their stability (PubMed:12684230). Upon metabolic acidosis, stabilizes the mRNA encoding SLC12A1 a cotransporter involved in transepithelial NH4(+) reabsorption in the medullary thick ascending limb in kidney (By similarity). In response to acidosis, also participates to the adaptive increase in renal ammoniagenesis by stabilizing the mRNAs of enzymes involved in glutamine catabolism (PubMed:12684230). By the same mechanism, it also regulates the expression of the antiapoptotic protein BCL2. Beside its mRNA stabilization activity, also catalyzes the reduction of orthoquinones such as 1,2-naphthoquinone or 9,10-phenanthrenequinone in the presence of NADPH in vitro and could be involved in the detoxification of xenobiotics and protection against oxidative stress (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.6.5.5", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003960 quinone reductase (NADPH) activity;GO:0003730 mRNA 3'-UTR binding;GO:0070402 NADPH binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0048255 mRNA stabilization;GO:0051289 protein homotetramerization;GO:0042178 xenobiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZAW2-1", "uniprot_id": "PISD_RAT", "mass": 45824.0, "length": 406, "protein_name": "Phosphatidylserine decarboxylase proenzyme, mitochondrial", "gene_name": "Pisd", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pisd; PISD", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylserine decarboxylase proenzyme, mitochondrial; 4.1.1.65", "protein_names_refseq": "", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (rno:681361)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2618245;6862014", "class_list": "", "function": "Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity)., [UniProtKB, UniProtKB, PubMed, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.65", "go_molecular_function": "GO:0004609 phosphatidylserine decarboxylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0016540 protein autoprocessing;GO:0035694 mitochondrial protein catabolic process;GO:0006646 phosphatidylethanolamine biosynthetic process;GO:0010821 regulation of mitochondrion organization;GO:0140042 lipid droplet formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZAW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63321-1", "uniprot_id": "PLOD1_RAT", "mass": 83612.0, "length": 728, "protein_name": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "gene_name": "Plod1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Plod1; Plod", "gene_names_refseq": "", "protein_names_uniprotkb": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; 1.14.11.4; LH1; Lysyl hydroxylase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Ehlers-Danlos syndrome kyphoscoliotic type 1 (Disease Ontology:DOID:0080734); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (rno:116552); (R-RNO-1650814)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7578263", "class_list": "", "function": "Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:7578263). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.50;1.14.11.4;2.4.1.66", "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0042277 peptide binding;GO:0008475 procollagen-lysine 5-dioxygenase activity;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix;GO:1902494 catalytic complex", "go_biological_process": "GO:0001666 response to hypoxia;GO:0008544 epidermis development;GO:0030199 collagen fibril organization;GO:0032870 cellular response to hormone stimulus;GO:0032964 collagen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925G0-1", "uniprot_id": "RBM3_RAT", "mass": 16855.0, "length": 155, "protein_name": "RNA-binding protein 3", "gene_name": "Rbm3", "organism": "Rat", "refseq_name": "RNA-binding protein 3", "refseq_ac": "NP_446148", "gene_names_uniprotkb": "Rbm3", "gene_names_refseq": "Rbm3", "protein_names_uniprotkb": "RNA-binding protein 3; RNA-binding motif protein 3", "protein_names_refseq": "RNA binding motif (RNP1, RRM) protein 3; RNA-binding protein 3; putative RNA-binding protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:114488)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15684048;17403028;18753264;19150436;24668366;26265550;29393594;30051360;33310754;38555015", "class_list": "", "function": "Aa cold-shock response may be part of a compensatory mechanism in muscles undergoing atrophy to preserve remaining muscle mass. RBM3, which was induced most highly in atrophic muscle from old rats, may be a therapeutic target to prevent muscle loss., [RefSeq, PubMed]; Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed (By similarity). Enhances phosphorylation of translation initiation factors and active polysome formation., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Overexpression of RBM3 also attenuated muscle atrophy in rat soleus muscle undergoing disuse atrophy. These findings provide direct evidence for a novel role of RBM3 in inducing hypertrophy as well as attenuating atrophy., [RefSeq, PubMed]; RBM3 Ameliorates Acute Brain Injury-induced Inflammation and Oxidative Stress by Stabilizing GAS6 mRNA Through Nrf2 Signaling Pathway., [RefSeq, PubMed]; RBM3 expression was increased in astrocytes after spinal cord injury. RBM3 regulated proliferation of astrocytes in vitro., [RefSeq, PubMed]; The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons., [RefSeq, PubMed]; These results indicate that expression of RBM3 is dynamically regulated in the developing brain and suggest that it contributes to translation-dependent processes underlying proliferation, differentiation, and plasticity., [RefSeq, PubMed]; This study showed that a 1 degrees C reduction in temperature can induce pleiotropic biochemical changes by upregulating global protein synthesis in neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0043023 ribosomal large subunit binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0009409 response to cold;GO:0006412 translation;GO:0045727 positive regulation of translation;GO:0035196 miRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q925G0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6UK00-1", "uniprot_id": "LDAF1_RAT", "mass": 17578.0, "length": 161, "protein_name": "Lipid droplet assembly factor 1", "gene_name": "Ldaf1", "organism": "Rat", "refseq_name": "lipid droplet assembly factor 1", "refseq_ac": "NP_919335", "gene_names_uniprotkb": "Ldaf1; Tmem159", "gene_names_refseq": "Ldaf1; Tmem159", "protein_names_uniprotkb": "Lipid droplet assembly factor 1; Promethin; Transmembrane protein 159", "protein_names_refseq": "lipid droplet assembly factor 1; promethin; transmembrane protein 159", "tax_id": 10116, "disease": "", "pathway": " (rno:378467)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15589683", "class_list": "", "function": "Plays an important role in the formation of lipid droplets during the differentiation and maturation of adipocytes. Together with seipin (BSCL2), defines the sites of lipid droplet formation in the endoplasmic reticulum and promotes the aggregation of triacylglycerol molecules to form the core of a lipid droplet (nucleation) in the endoplasmic reticulum and drive budding of lipid droplets into the cytoplasm., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DGG2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0140042 lipid droplet formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6UK00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K593-1", "uniprot_id": "PLPP2_RAT", "mass": 31101.0, "length": 276, "protein_name": "Phospholipid phosphatase 2", "gene_name": "Plpp2", "organism": "Rat", "refseq_name": "phospholipid phosphatase 2", "refseq_ac": "NP_640345", "gene_names_uniprotkb": "Plpp2; Lpp2; Ppap2c", "gene_names_refseq": "Plpp2; Ppap2c", "protein_names_uniprotkb": "Phospholipid phosphatase 2; 3.1.3.-; 3.1.3.4; Lipid phosphate phosphohydrolase 2; PAP-2c; PAP2-G; PAP2-gamma; PAP2c; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase 2c", "protein_names_refseq": "PAP-2c; PAP2-G; PAP2-gamma; PAP2c; lipid phosphate phosphohydrolase 2; phosphatidate phosphohydrolase type 2c; phosphatidic acid phosphatase 2c; phosphatidic acid phosphatase type 2c; phospholipid phosphatase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:246115); (R-RNO-9845614)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11704545;16467304", "class_list": "", "function": "Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (By similarity). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (PubMed:16467304)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.4;3.6.1.75;3.1.3.-;3.1.3.106;3.6.1.-;3.6.1.68", "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0106235 ceramide-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0007165 signal transduction;GO:0006672 ceramide metabolic process;GO:0006644 phospholipid metabolic process;GO:1902806 regulation of cell cycle G1/S phase transition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K593-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RZ50-1", "uniprot_id": "CDKN3_RAT", "mass": 23774.0, "length": 212, "protein_name": "Cyclin-dependent kinase inhibitor 3", "gene_name": "Cdkn3", "organism": "Rat", "refseq_name": "cyclin-dependent kinase inhibitor 3 isoform 1", "refseq_ac": "NP_001387969", "gene_names_uniprotkb": "Cdkn3; Kap", "gene_names_refseq": "Cdkn3", "protein_names_uniprotkb": "Cyclin-dependent kinase inhibitor 3; 3.1.3.16; 3.1.3.48; CDK2-associated dual-specificity phosphatase; Kinase-associated phosphatase", "protein_names_refseq": "CDK2-associated dual-specificity phosphatase; cyclin-dependent kinase inhibitor 3 isoform 1; kinase-associated phosphatase", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.16;2.7.10.1;3.1.3.53;3.1.3.2;3.1.3.52;3.1.3.21;3.1.3.18;3.1.3.67;3.1.3.-;3.1.3.27;3.1.3.5;2.7.11.22;3.1.3.74", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RZ50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMB0-1", "uniprot_id": "PLPR3_RAT", "mass": 76786.0, "length": 716, "protein_name": "Phospholipid phosphatase-related protein type 3", "gene_name": "Plppr3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Plppr3; Lppr3; Prg2", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 3; Inactive phospholipid phosphatase PLPPR3; Lipid phosphate phosphatase-related protein type 3; PRG-2; Plasticity-related gene 2 protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-419408)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12730698;38843836", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TMB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0I6-1", "uniprot_id": "XIAP_RAT", "mass": 56073.0, "length": 496, "protein_name": "E3 ubiquitin-protein ligase XIAP", "gene_name": "Xiap", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase XIAP", "refseq_ac": "NP_071567", "gene_names_uniprotkb": "Xiap; Api3; Birc4", "gene_names_refseq": "Api3; Birc4; Xiap; riap3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase XIAP; 2.3.2.27; Baculoviral IAP repeat-containing protein 4; IAP homolog A; IAP-3; Inhibitor of apoptosis protein 3; RING-type E3 ubiquitin transferase XIAP; X-linked IAP; X-linked inhibitor of apoptosis protein; rIAP-3; rIAP3", "protein_names_refseq": "E3 ubiquitin-protein ligase XIAP; IAP homolog A; IAP-3; RIAP-3; RING-type E3 ubiquitin transferase XIAP; X-linked IAP; X-linked inhibitor of apoptosis protein; X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase; apoptosis inhibitor protein 3; baculoviral IAP repeat-containing 4; baculoviral IAP repeat-containing protein 4; inhibitor of apoptosis protein 3", "tax_id": 10116, "disease": "X-linked lymphoproliferative syndrome 2 (Disease Ontology:DOID:0060706); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); breast ductal carcinoma (Disease Ontology:DOID:3007); renal cell carcinoma (Disease Ontology:DOID:4450); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:63879); (R-RNO-111459); (R-RNO-111463); (R-RNO-111464); (R-RNO-111469); (R-RNO-3769402); (R-RNO-5357786); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5675482); (R-RNO-8948747); (R-RNO-8948751); (R-RNO-9627069); (R-RNO-9958825)", "pathway_count": 14, "publication_count": 5, "publication_id_list": "11813002;32790238;33310074;33523568;38163563", "class_list": "", "function": "Effects of Different Degrees of Carotid Artery Stenosis on the Expression of XIAP and Smac in the Ischemic Penumbra of Rats with Cerebral Ischemia-Reperfusion., [RefSeq, PubMed]; MicroRNA-130a regulates neurological deficit and angiogenesis in rats with ischaemic stroke by targeting XIAP., [RefSeq, PubMed]; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin. Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling. 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis. Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program., [UniProtKB, UniProtKB]; Results show that inhibition of XIAP or NAIP activity prevents GDNF-mediated neuroprotective effects, suggesting that XIAP and NAIP are essential for intracellular signalling of GDNF in motor neuron survival (Birc4 protein)., [RefSeq, PubMed]; SP1-stimulated miR-208a-5p aggravates sepsis-induced myocardial injury via targeting XIAP., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.31;3.4.19.12;2.7.11.10;2.3.2.26;2.3.2.27;2.3.2.23;2.7.11.1;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;2.7.11.25;3.4.22.56;3.6.4.-;3.6.5.2;3.4.22.62", "go_molecular_function": "GO:0002020 protease binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0060785 regulation of apoptosis involved in tissue homeostasis;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R0I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z8X7-1", "uniprot_id": "CE104_RAT", "mass": 103790.0, "length": 922, "protein_name": "Centrosomal protein of 104 kDa", "gene_name": "Cep104", "organism": "Rat", "refseq_name": "centrosomal protein of 104 kDa", "refseq_ac": "NP_659550", "gene_names_uniprotkb": "Cep104", "gene_names_refseq": "Cep104; GlyBP", "protein_names_uniprotkb": "Centrosomal protein of 104 kDa; Cep104; Gly-, L-Glu and TCP-binding protein; GlyBP; Glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein", "protein_names_refseq": "centrosomal protein of 104 kDa; gly-, L-Glu and TCP-binding protein; glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein; glycine-, glutamate-, thienylcyclohexylpiperidine-binding protein", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 77 (Disease Ontology:DOID:0081236); Joubert syndrome 25 (Disease Ontology:DOID:0110994)", "pathway": " (rno:246295)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7488117", "class_list": "", "function": "Required for ciliogenesis and for structural integrity at the ciliary tip., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JUH6;Q62965", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0016594 glycine binding;GO:0016595 glutamate binding;GO:0016596 thienylcyclohexylpiperidine binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z8X7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63008-1", "uniprot_id": "SC5A5_RAT", "mass": 65196.0, "length": 618, "protein_name": "Sodium/iodide cotransporter", "gene_name": "Slc5a5", "organism": "Rat", "refseq_name": "sodium/iodide cotransporter", "refseq_ac": "NP_443215", "gene_names_uniprotkb": "Slc5a5; Nis", "gene_names_refseq": "Nis; Slc5a5", "protein_names_uniprotkb": "Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Sodium-iodide symporter; Solute carrier family 5 member 5", "protein_names_refseq": "Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na+/I- symporter; sodium/iodide cotransporter; sodium/iodide symporter; solute carrier family 5 (sodium iodide symporter), member 5; solute carrier family 5 (sodium/iodide cotransporter), member 5", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); thyroid dyshormonogenesis 1 (Disease Ontology:DOID:0112185)", "pathway": " (rno:114613); (R-RNO-209968); (R-RNO-9958790)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "29112772;32049985;32084174;35455992;36517601;8559252;8912659;9292938;9341168", "class_list": "", "function": "Relationship between the size of the goiter and NIS regulation, [RefSeq, PubMed]; Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:32084174, PubMed:36517601, PubMed:8559252, PubMed:9341168). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:9341168)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Structural insights into the mechanism of the sodium/iodide symporter., [RefSeq, PubMed]; TNFalpha-mediated activation of NF-kappaB downregulates sodium-iodide symporter expression in thyroid cells Publication Status: Online-Only, [RefSeq, PubMed]; Transcription Factor CREB3L1 Regulates the Expression of the Sodium/Iodide Symporter (NIS) in Rat Thyroid Follicular Cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 25, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0015293 symporter activity;GO:0015111 iodide transmembrane transporter activity;GO:0008507 sodium:iodide symporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:1904322 cellular response to forskolin;GO:0015705 iodide transport;GO:0006814 sodium ion transport;GO:0006590 thyroid hormone generation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q63008-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHJ4-1", "uniprot_id": "TM11D_RAT", "mass": 46288.0, "length": 417, "protein_name": "Transmembrane protease serine 11D", "gene_name": "Tmprss11d", "organism": "Rat", "refseq_name": "transmembrane protease serine 11D isoform a", "refseq_ac": "NP_001028824", "gene_names_uniprotkb": "Tmprss11d; Rat", "gene_names_refseq": "Asp; Tmprss11d", "protein_names_uniprotkb": "Transmembrane protease serine 11D; 3.4.21.-; AT; Adrenal secretory serine protease; Airway trypsin-like protease; AsP", "protein_names_refseq": "AT; adrenal secretory serine protease; airway trypsin-like protease; transmembrane protease serine 11D isoform a; transmembrane protease, serine 11d", "tax_id": 10116, "disease": "", "pathway": " (rno:64565)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11439186;12851306;14691009", "class_list": "", "function": "May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides (By similarity). Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC., [UniProtKB, PubMed]; Predominantly expressed in upper gastrointestinal and respiratory tract-but also in adrenal gland. Complex expression pattern. Multifunctional role beyond adrenal proliferation., [RefSeq, PubMed]; Results identify a secreted serine protease (adrenal secretory protease) expressed by the adrenal gland, which plays a role in adrenal growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZ74", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0040008 regulation of growth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VHJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFC1-1", "uniprot_id": "RIOX2_RAT", "mass": 53216.0, "length": 465, "protein_name": "Ribosomal oxygenase 2", "gene_name": "Riox2", "organism": "Rat", "refseq_name": "ribosomal oxygenase 2", "refseq_ac": "NP_695221", "gene_names_uniprotkb": "Riox2; Mina53; Mina", "gene_names_refseq": "Mina53; Riox2", "protein_names_uniprotkb": "Ribosomal oxygenase 2; 1.14.11.79; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; Histone lysine demethylase MINA; MYC-induced nuclear antigen", "protein_names_refseq": "MYC-induced nuclear antigen; Mina-53; bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; histone lysine demethylase MINA; myc induced nuclear antigen; ribosomal oxygenase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:266670); (R-RNO-3214842); (R-RNO-9629569)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "12091391", "class_list": "", "function": "Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.69;1.14.11.66;1.14.11.27;1.14.11.79;1.14.11.-", "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CFC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66HG0-1", "uniprot_id": "RNF13_RAT", "mass": 42585.0, "length": 380, "protein_name": "E3 ubiquitin-protein ligase RNF13", "gene_name": "Rnf13", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF13 precursor", "refseq_ac": "NP_001102914", "gene_names_uniprotkb": "Rnf13", "gene_names_refseq": "Rnf13", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF13; 2.3.2.27; RING finger protein 13", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF13 precursor; E3 ubiquitin-protein ligase RNF13; RING-type E3 ubiquitin transferase RNF13", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 73 (Disease Ontology:DOID:0112209)", "pathway": " (rno:681578)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that regulates cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. Also involved in protein trafficking and localization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Y81-1", "uniprot_id": "SEPT2_RAT", "mass": 41593.0, "length": 361, "protein_name": "Septin-2", "gene_name": "Septin2", "organism": "Rat", "refseq_name": "septin-2", "refseq_ac": "NP_476489", "gene_names_uniprotkb": "Septin2; Sept2; Vesp11", "gene_names_refseq": "Nedd5; Sept2; Septin2; Vesp11", "protein_names_uniprotkb": "Septin-2; Vascular endothelial cell specific protein 11", "protein_names_refseq": "septin-2; vascular endothelial cell specific protein 11", "tax_id": 10116, "disease": "", "pathway": " (rno:117515); (R-RNO-5620912)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12544826;15485874;16641100;22673903;25103794", "class_list": "", "function": "Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB]; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein (By similarity)., [UniProtKB, UniProtKB]; Nedd5 may be required for polarized neurite outgrowth, perhaps, by facilitating the exocyst complex function during neuronal differentiation., [RefSeq, PubMed]; This study illustrated the FHL2-driven molecular network controlling SEPT2-mediated apoptosis in mesangial cell and their potential roles in mesangial proliferative nephritis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0002036 regulation of L-glutamate import across plasma membrane;GO:0007283 spermatogenesis;GO:0031175 neuron projection development;GO:0007010 cytoskeleton organization;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91Y81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQZ1-1", "uniprot_id": "T22D3_RAT", "mass": 14836.0, "length": 134, "protein_name": "TSC22 domain family protein 3", "gene_name": "Tsc22d3", "organism": "Rat", "refseq_name": "TSC22 domain family protein 3 isoform 2", "refseq_ac": "NP_112635", "gene_names_uniprotkb": "Tsc22d3; Dsipi; Gilz", "gene_names_refseq": "Dsipi; Gilz; Tsc22d3", "protein_names_uniprotkb": "TSC22 domain family protein 3; Glucocorticoid-induced leucine zipper protein", "protein_names_refseq": "TSC22 domain family 3; TSC22 domain family protein 3 isoform 2; TSC22 domain family protein 3; delta sleep inducing peptide, immunoreactor; glucocorticoid-induced leucine zipper protein", "tax_id": 10116, "disease": "", "pathway": " (rno:83514); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12459854;12707381;17956870;22124125;22673903;23090754;25299205;28728173;31485805", "class_list": "", "function": "A role in blocking excitatory effects of glutamate on rat brain neurons, [RefSeq, PubMed]; GILZ has an important role not only in adjusting adaptive responses to hypoxia by negatively regulating the activation of macrophages and the expression of proinflammatory cytokines, [RefSeq, PubMed]; GILZ may be sensitive to the elevated expression of GC in septic muscle, promoting the expression and activation of GR involved in GC/GR-mediated proteolysis in septic skeletal muscle. Publication Status: Online-Only, [RefSeq, PubMed]; Glucocorticoid-induced leucine zipper protects noise-induced apoptosis in cochlear cells by inhibiting endoplasmic reticulum stress in rats., [RefSeq, PubMed]; Induction of GILZ mRNA may play a permissive role in the enhancement of the early and/or late responses; these effects may be necessary for a full response but do not by themselves promote early changes in urinary Na(+) and K(+) excretion., [RefSeq, PubMed]; Multiple GILZ isoforms are expressed in most cells and tissues and that these play distinct roles in regulating proliferation and ion transport., [RefSeq, PubMed]; Our data demonstrate GILZ induction in cardiomyocytes both in vivo and in vitro by glucocorticoids, pointing to H9c2(2-1) cells as a valid model for studying the biological function of GILZ in cardiomyocytes., [RefSeq, PubMed]; Overexpression of GILZ by OE-GILZ-rLV transduction protected the retina from light-induced cellular damage by activating antiapoptotic pathways., [RefSeq, PubMed]; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (By similarity). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (By similarity). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (By similarity). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043426 MRF binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006970 response to osmotic stress;GO:0007589 body fluid secretion;GO:0070236 negative regulation of activation-induced cell death of T cells;GO:0048642 negative regulation of skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9EQZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920M2-1", "uniprot_id": "RNF39_RAT", "mass": 38345.0, "length": 352, "protein_name": "RING finger protein 39", "gene_name": "Rnf39", "organism": "Rat", "refseq_name": "RING finger protein 39", "refseq_ac": "NP_599201", "gene_names_uniprotkb": "Rnf39; Lirf", "gene_names_refseq": "Hzfw1; Lirf; Rnf39", "protein_names_uniprotkb": "RING finger protein 39; 2.3.2.27; LTP-induced RING finger protein", "protein_names_refseq": "LTP-induced RING finger protein; RING finger protein 39", "tax_id": 10116, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (rno:171387)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10820183;11716498;15060004", "class_list": "", "function": "Plays an inhibitory role in anti-RNA viral innate immunity by targeting the adapter DDX3X and promoting its 'Lys-48'-linked polyubiquitination. Alternatively, enhances the cGAS-STING pathway activation by promoting 'Lys-63'-linked ubiquitination of STING1, facilitating the STING1-TBK1 complex formation and STING1 activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0048168 regulation of neuronal synaptic plasticity;GO:0070534 protein K63-linked ubiquitination;GO:0039532 negative regulation of cytoplasmic pattern recognition receptor signaling pathway;GO:0141111 positive regulation of cGAS/STING signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q920M2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810U0-1", "uniprot_id": "CCD50_RAT", "mass": 35158.0, "length": 305, "protein_name": "Coiled-coil domain-containing protein 50", "gene_name": "Ccdc50", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 50 isoform 2", "refseq_ac": "NP_877400", "gene_names_uniprotkb": "Ccdc50; C3orf6h", "gene_names_refseq": "C3orf6h; Ccdc50; c3orf6", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 50; Protein Ymer", "protein_names_refseq": "coiled-coil domain-containing protein 50 isoform 2; coiled-coil domain-containing protein 50; protein Ymer; putative C3orf6 protein homolog", "tax_id": 10116, "disease": "mantle cell lymphoma (Disease Ontology:DOID:0050746); autosomal dominant nonsyndromic deafness 44 (Disease Ontology:DOID:0110569)", "pathway": " (rno:288022)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14527723", "class_list": "", "function": "Involved in EGFR signaling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q810U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESS6-1", "uniprot_id": "BCAM_RAT", "mass": 67512.0, "length": 624, "protein_name": "Basal cell adhesion molecule", "gene_name": "Bcam", "organism": "Rat", "refseq_name": "basal cell adhesion molecule precursor", "refseq_ac": "NP_113940", "gene_names_uniprotkb": "Bcam; Lu", "gene_names_refseq": "Bcam; Lu", "protein_names_uniprotkb": "Basal cell adhesion molecule; B-CAM cell surface glycoprotein; Lutheran antigen", "protein_names_refseq": "B-CAM cell surface glycoprotein; Lutheran blood group (Auberger b antigen included); basal cell adhesion molecule precursor; lutheran antigen", "tax_id": 10116, "disease": "", "pathway": " (rno:78958)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24223164;36252138", "class_list": "", "function": "BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling., [RefSeq, PubMed]; Data indicate that the 14-3-3beta-FBI1/Akirin2 complex bound to the basal cell adhesion molecule (BCAM) promoter and repressed transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043236 laminin binding;GO:0005055 laminin receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ESS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z142-1", "uniprot_id": "TMM33_RAT", "mass": 27983.0, "length": 247, "protein_name": "Transmembrane protein 33", "gene_name": "Tmem33", "organism": "Rat", "refseq_name": "transmembrane protein 33 isoform 1", "refseq_ac": "NP_067703", "gene_names_uniprotkb": "Tmem33; Db83", "gene_names_refseq": "Tmem33", "protein_names_uniprotkb": "Transmembrane protein 33; Protein DB83", "protein_names_refseq": "db83; transmembrane protein 33 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:59303)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "38843836;9872456", "class_list": "", "function": "Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling. Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome;GO:0016020 membrane", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0045087 innate immune response;GO:0061024 membrane organization;GO:1903896 positive regulation of IRE1-mediated unfolded protein response;GO:1903899 positive regulation of PERK-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z142-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CJI3-1", "uniprot_id": "S12A8_RAT", "mass": 77073.0, "length": 707, "protein_name": "Solute carrier family 12 member 8", "gene_name": "Slc12a8", "organism": "Rat", "refseq_name": "solute carrier family 12 member 8", "refseq_ac": "NP_705889", "gene_names_uniprotkb": "Slc12a8; Ccc9", "gene_names_refseq": "Ccc9; Slc12a8", "protein_names_uniprotkb": "Solute carrier family 12 member 8; Cation-chloride cotransporter 9", "protein_names_refseq": "cation-chloride cotransporter 9; solute carrier family 12 (potassium/chloride transporters), member 8; solute carrier family 12 member 8", "tax_id": 10116, "disease": "", "pathway": " (rno:266733)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CJI2", "ec_number_list": "", "go_molecular_function": "GO:0015379 potassium:chloride symporter activity;GO:0015377 chloride:monoatomic cation symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis;GO:1990573 potassium ion import across plasma membrane;GO:0055064 chloride ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CJI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIB1-1", "uniprot_id": "TSSC4_RAT", "mass": 33939.0, "length": 317, "protein_name": "U5 small nuclear ribonucleoprotein TSSC4", "gene_name": "Tssc4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tssc4", "gene_names_refseq": "", "protein_names_uniprotkb": "U5 small nuclear ribonucleoprotein TSSC4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:361682)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0005682 U5 snRNP", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000387 spliceosomal snRNP assembly;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYT3-1", "uniprot_id": "RTCB_RAT", "mass": 55249.0, "length": 505, "protein_name": "RNA-splicing ligase RTCB", "gene_name": "Rtcb", "organism": "Rat", "refseq_name": "RNA-splicing ligase RTCB", "refseq_ac": "NP_997497", "gene_names_uniprotkb": "Rtcb; RTCB", "gene_names_refseq": "Rtcb", "protein_names_uniprotkb": "RNA-splicing ligase RTCB; 3'-phosphate/5'-hydroxy nucleic acid ligase; 6.5.1.8; RNA 2',3'-cyclic phosphate and 5'-OH ligase; p55", "protein_names_refseq": "3'-phosphate/5'-hydroxy nucleic acid ligase; P55; RNA-splicing ligase RTCB; RNA-splicing ligase RtcB homolog; tRNA-splicing ligase RtcB homolog", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:362855)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "3'-5' RNA ligase, catalytic subunit of the tRNA-splicing ligase complex (tRNA-LC), which is involved in the enzyme-dependent maturation of intron-containing pre-tRNAs. Functions downstream of the tRNA-splicing endonuclease that removes introns, ligating the two generated halves via phosphodiester bond formation. The ligation reaction, which requires guanosine triphosphate (GTP) and Mn(2+), proceeds through three metal-dependent steps. The first step requires ZBTB8OS/Archease and involves the guanylylation of RTCB at its active site histidine, forming a covalent GMP-histidine intermediate. Before the second step, RTCB also hydrolyzes the 2',3'-cyclic phosphate (cP) at the 3' end of the 5' tRNA exon, typically generated by the tRNA-splicing endonuclease, producing a 3' phosphate. The covalently bound GMP is then transferred to this 3' phosphate to form an RNA(3')-P-P-(5')G intermediate. In the final step, the 5'-OH of the 3' exon attacks the activated 3' end of the 5' exon, forming a 3'-5' phosphodiester bond and releasing GMP. RTCB also functions in non-canonical, spliceosome-independent, cytoplasmic splicing of XBP1 mRNAs during the unfolded protein response (UPR). Upon endoplasmic reticulum (ER) stress, the endoribonuclease IRE1/ERN1 excises a short intron, generating free exon ends that are aligned by RNA-intrinsic, zipper-like stem-loop structures. These exon ends are then recognized and ligated by RTCB. This splicing event yields the active XBP1s transcription factor, which induces genes required to resolve protein folding defects in the endoplasmic reticulum., [UniProtKB, UniProtKB]; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PX76", "ec_number_list": "6.5.1.8", "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0017166 vinculin binding;GO:0170057 RNA ligase (GTP) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation;GO:0001701 in utero embryonic development;GO:0036498 IRE1-mediated unfolded protein response;GO:0001890 placenta development;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AYT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IRK9-1", "uniprot_id": "CBPQ_RAT", "mass": 52042.0, "length": 472, "protein_name": "Carboxypeptidase Q", "gene_name": "Cpq", "organism": "Rat", "refseq_name": "carboxypeptidase Q isoform 1 precursor", "refseq_ac": "NP_001426967", "gene_names_uniprotkb": "Cpq; Pgcp", "gene_names_refseq": "Cpq; LAL; Pgcp; lal-1", "protein_names_uniprotkb": "Carboxypeptidase Q; 3.4.17.-; Hematopoietic lineage switch 2 related protein; Hls2-rp; LAL-1; Liver annexin-like protein 1; Plasma glutamate carboxypeptidase", "protein_names_refseq": "carboxypeptidase Q isoform 1 precursor; hematopoietic lineage switch 2 related protein; hls2-rp; liver annexin like-1; liver annexin-like protein 1; plasma glutamate carboxypeptidase", "tax_id": 10116, "disease": "", "pathway": " (rno:58952)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12390252;22127294", "class_list": "", "function": "Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Lal-1 is involved in liver regeneration and its expression is finely regulated during proliferative process {Liver Annexin Like-1 (lal-1), [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLV0;Q9Z1Y1", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0070573 metallodipeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process;GO:0042246 tissue regeneration;GO:0006590 thyroid hormone generation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6IRK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K581-1", "uniprot_id": "TXND9_RAT", "mass": 26272.0, "length": 226, "protein_name": "Thioredoxin domain-containing protein 9", "gene_name": "Txndc9", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Txndc9", "gene_names_refseq": "", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 9; ES cell-related protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:280671)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030496 midbody", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K581-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYA0-1", "uniprot_id": "RIPL2_RAT", "mass": 22445.0, "length": 197, "protein_name": "RILP-like protein 2", "gene_name": "Rilpl2", "organism": "Rat", "refseq_name": "RILP-like protein 2", "refseq_ac": "NP_001004205", "gene_names_uniprotkb": "Rilpl2", "gene_names_refseq": "Rilpl2", "protein_names_uniprotkb": "RILP-like protein 2; Rab-interacting lysosomal-like protein 2", "protein_names_refseq": "RILP-like protein 2; rab-interacting lysosomal-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:288652)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19812310", "class_list": "", "function": "Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (PubMed:19812310). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). May function via activation of RAC1 and PAK1 (PubMed:19812310)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; These data represent a novel mechanism linking RILPL2, the motor protein MyoVa and Rac1 with neuronal structure and function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0031267 small GTPase binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0060271 cilium assembly;GO:0003382 epithelial cell morphogenesis;GO:1903445 protein transport from ciliary membrane to plasma membrane;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMI9-1", "uniprot_id": "TRPC3_RAT", "mass": 103499.0, "length": 909, "protein_name": "Short transient receptor potential channel 3", "gene_name": "Trpc3", "organism": "Rat", "refseq_name": "short transient receptor potential channel 3", "refseq_ac": "NP_001401934", "gene_names_uniprotkb": "Trpc3; Trrp3", "gene_names_refseq": "TrpC3c; Trpc3; Trrp3", "protein_names_uniprotkb": "Short transient receptor potential channel 3; Trp-related protein 3; TrpC3", "protein_names_refseq": "ion channel protein; short transient receptor potential channel 3; trp-related protein 3", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); cerebellar ataxia type 41 (Disease Ontology:DOID:0111744); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:60395); (R-RNO-114508); (R-RNO-139853); (R-RNO-3295583)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10984475;12938168;29748835;30318928;34497367;36613540;36669577", "class_list": "", "function": "Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein coupled receptors., [UniProtKB, UniProtKB]; Increased transient receptor potential canonical 3 activity is involved in the pathogenesis of detrusor overactivity by dynamic interaction with Na(+)/Ca(2+) exchanger 1., [RefSeq, PubMed]; Inhibition of TRPC3 suppressed intracellular Ca(2+) levels in hyperthermia-treated hippocampal neuronal cells, [RefSeq, PubMed]; Results suggest that an endogenous transient receptor potential-canonical (TRPC3)-like protein is involved in the route activated by 1alpha,25(OH)(2)D3 in a secosteroid target cell., [RefSeq, PubMed]; Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPbeta., [RefSeq, PubMed]; TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation. Publication Status: Online-Only, [RefSeq, PubMed]; We demonstrate that TRPC3-NFATc3 signaling is modulated by P.E. and critically regulates ventricular CF phenotype and MF. These findings strongly argue for P.E., through TRPC3 targeting, as potential and interesting therapeutics for MF management., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LNQ7", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005262 calcium channel activity;GO:0046872 metal ion binding;GO:0005227 calcium-activated cation channel activity;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress;GO:0051592 response to calcium ion;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007338 single fertilization;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JMI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B4F766-1", "uniprot_id": "DYM_RAT", "mass": 76491.0, "length": 674, "protein_name": "Dymeclin", "gene_name": "Dym", "organism": "Rat", "refseq_name": "dymeclin isoform X3", "refseq_ac": "XP_017456369", "gene_names_uniprotkb": "Dym", "gene_names_refseq": "Dym; RGD1309111", "protein_names_uniprotkb": "Dymeclin", "protein_names_refseq": "dymeclin isoform X3", "tax_id": 10116, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Smith-McCort dysplasia 1 (Disease Ontology:DOID:0081270); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (rno:291433)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Necessary for correct organization of Golgi apparatus. Involved in bone development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0060348 bone development;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B4F766-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FS7-1", "uniprot_id": "TM183_RAT", "mass": 42982.0, "length": 376, "protein_name": "Transmembrane protein 183", "gene_name": "Tmem183a; Tmem183", "organism": "Rat", "refseq_name": "transmembrane protein 183", "refseq_ac": "NP_001013893", "gene_names_uniprotkb": "Tmem183a; Tmem183", "gene_names_refseq": "RGD1309892; Tmem183a; Tmem183", "protein_names_uniprotkb": "Transmembrane protein 183", "protein_names_refseq": "clone MNCb-2755; transmembrane protein 183", "tax_id": 10116, "disease": "", "pathway": " (rno:289034)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FT3-1", "uniprot_id": "PYRD2_RAT", "mass": 62879.0, "length": 581, "protein_name": "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "gene_name": "Pyroxd2", "organism": "Rat", "refseq_name": "pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "refseq_ac": "NP_001004261", "gene_names_uniprotkb": "Pyroxd2", "gene_names_refseq": "Pyroxd2; RGD1303232", "protein_names_uniprotkb": "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; 1.-.-.-", "protein_names_refseq": "Phytn_dehydro and Pyr_redox domain containing protein RGD1303232; pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:309381)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable oxidoreductase that may play a role as regulator of mitochondrial function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923Y6-1", "uniprot_id": "TAAR9_RAT", "mass": 37846.0, "length": 338, "protein_name": "Trace amine-associated receptor 9", "gene_name": "Taar9", "organism": "Rat", "refseq_name": "trace amine-associated receptor 9", "refseq_ac": "NP_783192", "gene_names_uniprotkb": "Taar9; Ta3; Tar3; Trar3", "gene_names_refseq": "Ta3; Taar9", "protein_names_uniprotkb": "Trace amine-associated receptor 9; TaR-3; TaR-9; Trace amine receptor 3; Trace amine receptor 9", "protein_names_refseq": "taR-3; taR-9; trace amine receptor 3; trace amine receptor 9; trace amine-associated receptor 9", "tax_id": 10116, "disease": "", "pathway": " (rno:319107); (R-RNO-375280)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11459929;22545963;33799339;34600890", "class_list": "", "function": "Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels. Publication Status: Online-Only, [RefSeq, PubMed]; Olfactory receptor specific for trace amines, such as triethylamine, N-methylpiperidine, N,N-dimethylcyclohexylamine (DMCHA), beta-phenylethylamine (beta-PEA), cadaverine (CAD) and polyamines such as spermidine (PubMed:22545963, PubMed:34600890). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (By similarity). Trace amine-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (By similarity). In mature olfactory sensory neurons, Taar9 is coupled with GNAL/G(olf)G alpha protein and mediates activation of adenylate cyclase activity to activate cAMP signaling and eventually transmit odorant signals to achieve membrane depolarization (By similarity). In immature olfactory sensory neurons, Taar9 is coupled with GNAS/G(s) G alpha proteins (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q923Y6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUL0-1", "uniprot_id": "TOP1_RAT", "mass": 90760.0, "length": 767, "protein_name": "DNA topoisomerase 1", "gene_name": "Top1", "organism": "Rat", "refseq_name": "DNA topoisomerase 1", "refseq_ac": "NP_072137", "gene_names_uniprotkb": "Top1", "gene_names_refseq": "Ab2-086; Top1", "protein_names_uniprotkb": "DNA topoisomerase 1; 5.6.2.1; DNA topoisomerase I", "protein_names_refseq": "DNA topoisomerase 1; topoisomerase (DNA) I", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:64550); (R-RNO-4615885)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22247452;22673903;23012366", "class_list": "", "function": "Rac1-regulated mechanisms are required for DNA damage induction and subsequent activation of the DDR following treatment with topo II but not topo I poisons, [RefSeq, PubMed]; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;5.6.2.1", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0043204 perikaryon", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0007059 chromosome segregation;GO:0010332 response to gamma radiation;GO:0006260 DNA replication;GO:0009266 response to temperature stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WUL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WY6-1", "uniprot_id": "TNR1B_RAT", "mass": 50148.0, "length": 474, "protein_name": "Tumor necrosis factor receptor superfamily member 1B", "gene_name": "Tnfrsf1b", "organism": "Rat", "refseq_name": "tumor necrosis factor receptor superfamily member 1B precursor", "refseq_ac": "NP_569110", "gene_names_uniprotkb": "Tnfrsf1b; Tnfr2", "gene_names_refseq": "Tnfr2; Tnfrsf1b", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; TNFR-II; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor", "protein_names_refseq": "TNF-R2; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B precursor; tumor necrosis factor receptor superfamily, member 1b; tumor necrosis factor receptor type II", "tax_id": 10116, "disease": "cryptogenic organizing pneumonia (Disease Ontology:DOID:0050157); lupus nephritis (Disease Ontology:DOID:0080162); polymyositis (Disease Ontology:DOID:0080745); Parkinsonism (Disease Ontology:DOID:0080855); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); colon carcinoma (Disease Ontology:DOID:1520); ovarian cancer (Disease Ontology:DOID:2394); endometriosis (Disease Ontology:DOID:289); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); tuberculosis (Disease Ontology:DOID:399); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); acne (Disease Ontology:DOID:6543); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); extrinsic allergic alveolitis (Disease Ontology:DOID:841); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:156767); (R-RNO-5668541); (R-RNO-5669034); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "27979472;29975930;30988334", "class_list": "", "function": "Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR2- and Orai3- dependent signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results suggested that PTE may promote BMSC proliferation and osteogenic differentiation via a mechanism associated with the regulation of Let-7f-5p and the TNFR2/PI3K/AKT signaling pathway., [RefSeq, PubMed]; TNF plays an inhibitory role in modulating myocardial SDF-1 production and blockade of TNF signaling by ablation of TNFR1 and TNFR2 genes increased SDF-1 expression in the heart. These data expand on TNF signaling-initiated mechanisms in myocardium, which may lend a more complete understanding of SDF-1 and TNFR-derived actions in hopes of advancing ischemic heart injury treatments., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 3, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5YLP0", "ec_number_list": "", "go_molecular_function": "GO:0043120 tumor necrosis factor binding;GO:0031625 ubiquitin protein ligase binding;GO:0005031 tumor necrosis factor receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0045121 membrane raft", "go_biological_process": "GO:0050779 RNA destabilization;GO:0002718 regulation of cytokine production involved in immune response;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80WY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6J1Y9-1", "uniprot_id": "UBP19_RAT", "mass": 150302.0, "length": 1357, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 19", "gene_name": "Usp19", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 19", "refseq_ac": "NP_001001516", "gene_names_uniprotkb": "Usp19", "gene_names_refseq": "Usp19", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 19; 3.4.19.12; Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19", "protein_names_refseq": "deubiquitinating enzyme 19; ubiquitin carboxyl-terminal hydrolase 19; ubiquitin specific protease 19; ubiquitin thioesterase 19; ubiquitin thiolesterase 19; ubiquitin-specific-processing protease 19", "tax_id": 10116, "disease": "", "pathway": " (rno:361190); (R-RNO-5689880)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15562254;19015242;19773579;22673903;25568336;27156111;32798288", "class_list": "", "function": "Deubiquitinating enzyme that regulates the degradation of various proteins by removing ubiquitin moieties, thereby preventing their proteasomal degradation. Stabilizes RNF123, which promotes CDKN1B degradation and contributes to cell proliferation (PubMed:19015242). Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Modulates transcription of major myofibrillar proteins (PubMed:19773579). Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (By similarity). Mechanistically, deubiquitinates and thereby stabilizes several E3 ligases involved in the ERAD pathway including SYVN1 or MARCHF6 (By similarity). Regulates the stability of other E3 ligases including BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia by rescuing HIF1A from degradation in a non-catalytic manner and by mediating the deubiquitination of FUNDC1. Attenuates mitochondrial damage and ferroptosis by targeting and stabilizing NADPH oxidase 4/NOX4 (By similarity). Negatively regulates TNF- and IL-1beta-triggered NF-kappa-B activation by hydrolyzing 'Lys-27'- and 'Lys-63'-linked polyubiquitin chains from MAP3K7 (By similarity). Modulates also the protein level and aggregation of polyQ-expanded huntingtin/HTT through HSP90AA1 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Deubiquitination by USP19 does modulate muscle cell differentiation and that this function requires the ER-localized isoform and appears to act through regulation of the unfolded-protein response (UPR) signaling., [RefSeq, PubMed]; High iodine intake had no discernible effects on USP20. Temporary increases in USP33 and USP19 mRNA levels were observed. The enzymes related to D2 ubiquitination change with prolonged high iodine intake. Increased D2 ubiquitination suppresses the activity of D2, causing a decrease in negative feedback of the hypothalamic-pituitary-thyroid axis., [RefSeq, PubMed]; Study reports that the USP19 deubiquitinating enzyme interacts with and stabilizes KPC1, thereby modulating p27(Kip1) levels and cell proliferation Erratum:[Mol Cell Biol. 2009 Jun;29(11):3241], [RefSeq, PubMed]; USP19 is regulated in rat skeletal muscle during catabolic states., [RefSeq, PubMed]; USP19 modulates transcription of major myofibrillar proteins., [RefSeq, PubMed]; Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;3.4.19.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0051879 Hsp90 protein binding;GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904292 regulation of ERAD pathway;GO:0016579 protein deubiquitination;GO:0050821 protein stabilization;GO:0031647 regulation of protein stability;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6J1Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M767-1", "uniprot_id": "UB2V2_RAT", "mass": 16353.0, "length": 145, "protein_name": "Ubiquitin-conjugating enzyme E2 variant 2", "gene_name": "Ube2v2", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 variant 2", "refseq_ac": "NP_898875", "gene_names_uniprotkb": "Ube2v2; Mms2; Uev2", "gene_names_refseq": "MMS2; Ube2v2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 variant 2; Ubiquitin-conjugating enzyme variant MMS2", "protein_names_refseq": "ubiquitin-conjugating enzyme E2 variant 2; ubiquitin-conjugating enzyme E2v2; ubiquitin-conjugating enzyme variant MMS2", "tax_id": 10116, "disease": "", "pathway": " (rno:287927); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-5696395); (R-RNO-69473); (R-RNO-8866654); (R-RNO-983168)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "12750002;17068200", "class_list": "", "function": "Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHN0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031372 UBC13-MMS2 complex", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0043524 negative regulation of neuron apoptotic process;GO:0045739 positive regulation of DNA repair;GO:0051965 positive regulation of synapse assembly;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7M767-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62935-1", "uniprot_id": "VWF_RAT", "mass": 48139.0, "length": 430, "protein_name": "von Willebrand factor", "gene_name": "Vwf", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Vwf", "gene_names_refseq": "", "protein_names_uniprotkb": "von Willebrand factor; vWF", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); atrial fibrillation (Disease Ontology:DOID:0060224); von Willebrand's disease 1 (Disease Ontology:DOID:0060573); von Willebrand's disease 2 (Disease Ontology:DOID:0060574); thrombosis (Disease Ontology:DOID:0060903); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); von Willebrand's disease 3 (Disease Ontology:DOID:0111054); osteonecrosis (Disease Ontology:DOID:10159); hypertension (Disease Ontology:DOID:10763); intracranial aneurysm (Disease Ontology:DOID:10941); alcoholic hepatitis (Disease Ontology:DOID:12351); von Willebrand's disease (Disease Ontology:DOID:12531); endomyocardial fibrosis (Disease Ontology:DOID:12932); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); Behcet's disease (Disease Ontology:DOID:13241); familial combined hyperlipidemia (Disease Ontology:DOID:13809); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); aortic valve stenosis (Disease Ontology:DOID:1712); Bernard-Soulier syndrome (Disease Ontology:DOID:2217); essential thrombocythemia (Disease Ontology:DOID:2224); transient cerebral ischemia (Disease Ontology:DOID:224); bipolar disorder (Disease Ontology:DOID:3312); carotid artery disease (Disease Ontology:DOID:3407); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); alcoholic pancreatitis (Disease Ontology:DOID:4988); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:116669)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10335651;12871266", "class_list": "", "function": "Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 3, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 39, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q78E31;Q9Z0P2", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix", "go_biological_process": "GO:0070417 cellular response to cold;GO:0001889 liver development;GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62935-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY05-1", "uniprot_id": "TM175_RAT", "mass": 55706.0, "length": 499, "protein_name": "Endosomal/lysosomal proton channel TMEM175", "gene_name": "Tmem175", "organism": "Rat", "refseq_name": "endosomal/lysosomal proton channel TMEM175", "refseq_ac": "NP_001014013", "gene_names_uniprotkb": "Tmem175", "gene_names_refseq": "RGD1309712; Tmem175", "protein_names_uniprotkb": "Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175", "protein_names_refseq": "endosomal/lysomomal potassium channel TMEM175; endosomal/lysosomal potassium channel TMEM175; endosomal/lysosomal proton channel TMEM175", "tax_id": 10116, "disease": "", "pathway": " (rno:305623)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23436907;28193887;32799888", "class_list": "", "function": "Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (By similarity). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (By similarity). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (By similarity). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (By similarity). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (By similarity). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (By similarity). The lysoK(GF) complex is required to protect neurons against stress-induced damage (Probable) (PubMed:32799888)., [UniProtKB, PubMed, UniProtKB]; TMEM175 deficiency impairs lysosomal and mitochondrial function and increases alpha-synuclein aggregation., [RefSeq, PubMed]; TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0022841 potassium ion leak channel activity;GO:0005267 potassium channel activity;GO:0050544 arachidonate binding;GO:0015252 proton channel activity", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0070050 neuron cellular homeostasis;GO:0035752 lysosomal lumen pH elevation;GO:0090385 phagosome-lysosome fusion;GO:0071805 potassium ion transmembrane transport;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AY05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1L131-1", "uniprot_id": "CUED2_RAT", "mass": 30282.0, "length": 267, "protein_name": "CUE domain-containing protein 2", "gene_name": "Cuedc2", "organism": "Rat", "refseq_name": "CUE domain-containing protein 2", "refseq_ac": "NP_001073355", "gene_names_uniprotkb": "Cuedc2", "gene_names_refseq": "Cuedc2", "protein_names_uniprotkb": "CUE domain-containing protein 2", "protein_names_refseq": "CUE domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:294009)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29393594;33494071", "class_list": "", "function": "CUEDC2 ablation enhances the efficacy of mesenchymal stem cells in ameliorating cerebral ischemia/reperfusion insult., [RefSeq, PubMed]; Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1900016 negative regulation of cytokine production involved in inflammatory response;GO:0010936 negative regulation of macrophage cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A1L131-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2GV77-1", "uniprot_id": "NXT2_RAT", "mass": 16366.0, "length": 142, "protein_name": "NTF2-related export protein 2", "gene_name": "Nxt2", "organism": "Rat", "refseq_name": "NTF2-related export protein 2", "refseq_ac": "NP_001101590", "gene_names_uniprotkb": "Nxt2", "gene_names_refseq": "Nxt2; RGD1560204", "protein_names_uniprotkb": "NTF2-related export protein 2", "protein_names_refseq": "NTF2-related export protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:315352)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35219094", "class_list": "", "function": "Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents., [RefSeq, PubMed]; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0042272 nuclear RNA export factor complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0015031 protein transport;GO:0006913 nucleocytoplasmic transport;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2GV77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B4F795-1", "uniprot_id": "CTL2_RAT", "mass": 79897.0, "length": 705, "protein_name": "Choline transporter-like protein 2", "gene_name": "Slc44a2", "organism": "Rat", "refseq_name": "choline transporter-like protein 2", "refseq_ac": "NP_001128187", "gene_names_uniprotkb": "Slc44a2; Ctl2", "gene_names_refseq": "RGD1309680; Slc44a2", "protein_names_uniprotkb": "Choline transporter-like protein 2; Solute carrier family 44 member 2", "protein_names_refseq": "choline transporter-like protein 2; solute carrier family 44 (choline transporter), member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:363024); (R-RNO-1483191); (R-RNO-6798163); (R-RNO-6798695); (R-RNO-9958517)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "19236841;24090084;38843836", "class_list": "", "function": "Choline transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Exhibits choline transporter activity, as choline/H+ antiporter (PubMed:19236841). Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015871 choline transport;GO:0034229 ethanolamine transport;GO:0015695 organic cation transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B4F795-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMP6-1", "uniprot_id": "T255A_RAT", "mass": 38616.0, "length": 351, "protein_name": "Transmembrane protein 255A", "gene_name": "Tmem255a", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tmem255a; Fam70a", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein 255A; Protein FAM70A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:313453)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TMP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQ84-1", "uniprot_id": "UIF_RAT", "mass": 35642.0, "length": 317, "protein_name": "UAP56-interacting factor", "gene_name": "Fyttd1", "organism": "Rat", "refseq_name": "UAP56-interacting factor", "refseq_ac": "NP_001386212", "gene_names_uniprotkb": "Fyttd1; Ac1176; Uif", "gene_names_refseq": "Ac1176; Fyttd1; RGD1306899", "protein_names_uniprotkb": "UAP56-interacting factor; Forty-two-three domain-containing protein 1; Protein 40-2-3", "protein_names_refseq": "UAP56-interacting factor; forty-two-three domain-containing protein 1; protein 40-2-3", "tax_id": 10116, "disease": "", "pathway": " (rno:360726); (R-RNO-159236)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006406 mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQ84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PDW6-1", "uniprot_id": "RM17_RAT", "mass": 20264.0, "length": 176, "protein_name": "Large ribosomal subunit protein bL17m", "gene_name": "Mrpl17", "organism": "Rat", "refseq_name": "large ribosomal subunit protein bL17m isoform 1 precursor", "refseq_ac": "NP_001300771", "gene_names_uniprotkb": "Mrpl17", "gene_names_refseq": "L17mt; MRP-L17; Mrpl17", "protein_names_uniprotkb": "Large ribosomal subunit protein bL17m; 39S ribosomal protein L17, mitochondrial; L17mt; MRP-L17", "protein_names_refseq": "39S ribosomal protein L17, mitochondrial; Na++/Ca++ exchanger-associated protein; large ribosomal subunit protein bL17m isoform 1 precursor; large ribosomal subunit protein bL17m", "tax_id": 10116, "disease": "", "pathway": " (rno:171061); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EPG8", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PDW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IM78-1", "uniprot_id": "TOP1M_RAT", "mass": 69011.0, "length": 593, "protein_name": "DNA topoisomerase I, mitochondrial", "gene_name": "Ly6h; Top1mt", "organism": "Rat", "refseq_name": "DNA topoisomerase I, mitochondrial", "refseq_ac": "NP_001002798", "gene_names_uniprotkb": "Ly6h; Top1mt; Ly6h; Top1mt", "gene_names_refseq": "Top1mt", "protein_names_uniprotkb": "DNA topoisomerase I, mitochondrial; 5.6.2.1; TOP1mt", "protein_names_refseq": "DNA topoisomerase 1, mitochondrial; DNA topoisomerase I, mitochondrial; mitochondrial topoisomerase I; topoisomerase (DNA) I, mitochondrial", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:300029); (R-RNO-163125)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15096574;29393594", "class_list": "", "function": "Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)., [UniProtKB]; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity;GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0005694 chromosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006260 DNA replication;GO:0006265 DNA topological change;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6IM78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Y78-1", "uniprot_id": "UCHL3_RAT", "mass": 26124.0, "length": 230, "protein_name": "Ubiquitin carboxyl-terminal hydrolase isozyme L3", "gene_name": "Uchl3", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2", "refseq_ac": "NP_001103635", "gene_names_uniprotkb": "Uchl3", "gene_names_refseq": "RGD1561196; UCH-L3; Uchl3", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase isozyme L3; 3.4.19.12; UCH-L3; Ubiquitin thioesterase L3", "protein_names_refseq": "ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2; ubiquitin carboxyl-terminal hydrolase isozyme L3; ubiquitin thioesterase L3", "tax_id": 10116, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); Parkinson's disease (Disease Ontology:DOID:14330); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:498560); (R-RNO-5689603); (R-RNO-8866652); (R-RNO-8951664)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains (By similarity). Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurodegenerative disorders (By similarity). Involved in DNA repair via homologous recombination (HR) by mediating deubiquitination of RAD51 in response to DNA damage, promoting interaction between RAD51 and BRCA2 (By similarity). Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12;3.4.22.-", "go_molecular_function": "GO:0008233 peptidase activity;GO:0043130 ubiquitin binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0032869 cellular response to insulin stimulus;GO:0045600 positive regulation of fat cell differentiation;GO:0042755 eating behavior;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91Y78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q673L6-1", "uniprot_id": "TERT_RAT", "mass": 126934.0, "length": 1125, "protein_name": "Telomerase reverse transcriptase", "gene_name": "Tert", "organism": "Rat", "refseq_name": "telomerase reverse transcriptase", "refseq_ac": "NP_445875", "gene_names_uniprotkb": "Tert", "gene_names_refseq": "Tert", "protein_names_uniprotkb": "Telomerase reverse transcriptase; 2.7.7.49; Telomerase catalytic subunit", "protein_names_refseq": "telomerase catalytic subunit; telomerase reverse transcriptase", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); small cell carcinoma (Disease Ontology:DOID:0050685); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); ductal carcinoma in situ (Disease Ontology:DOID:0060074); autosomal dominant dyskeratosis congenita 2 (Disease Ontology:DOID:0070016); prostate cancer (Disease Ontology:DOID:10283); silicosis (Disease Ontology:DOID:10325); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); beta thalassemia (Disease Ontology:DOID:12241); aplastic anemia (Disease Ontology:DOID:12449); brain cancer (Disease Ontology:DOID:1319); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); hepatitis C (Disease Ontology:DOID:1883); viral hepatitis (Disease Ontology:DOID:1884); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); transitional cell carcinoma (Disease Ontology:DOID:2671); teratoma (Disease Ontology:DOID:3307); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); gallbladder carcinoma (Disease Ontology:DOID:4948); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); familial melanoma (Disease Ontology:DOID:6846); chronic kidney disease (Disease Ontology:DOID:784); chronic myeloid leukemia (Disease Ontology:DOID:8552); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); nasopharynx carcinoma (Disease Ontology:DOID:9261); plasma cell leukemia (Disease Ontology:DOID:9513); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:301965); (R-RNO-171319); (R-RNO-174430); (R-RNO-201722)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "12729609;16205635;16454671;33999989;34559580;36299510;38373547", "class_list": "", "function": "Autophagy, TERT, and mitochondrial dysfunction in hyperoxia., [RefSeq, PubMed]; Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis. Erratum:[Carcinogenesis. 2021 Oct 26;42(10):1304. doi: 10.1093/carcin/bgab084. PMID: 34605906], [RefSeq, PubMed]; TERT-independent telomere elongation and shelterin dysregulation after pulmonary exposure to stainless-steel welding fume in-vivo., [RefSeq, PubMed]; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 42, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZ57;Q4U0V7;Q673L3;Q673L5;Q80SU5", "ec_number_list": "2.7.7.7;2.7.7.102;2.7.7.49;3.6.4.12;2.7.7.31;3.1.11.-;4.2.99.18;4.2.99.-;5.4.99.-;5.6.2.3;5.6.2.-;2.7.11.22;3.1.3.16;3.6.4.-", "go_molecular_function": "GO:0003964 RNA-directed DNA polymerase activity;GO:0003968 RNA-directed RNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006278 RNA-templated DNA biosynthetic process;GO:0071897 DNA biosynthetic process;GO:2000648 positive regulation of stem cell proliferation;GO:0007507 heart development;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q673L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHT8-1", "uniprot_id": "TF3A_RAT", "mass": 41387.0, "length": 363, "protein_name": "Transcription factor IIIA", "gene_name": "Gtf3a", "organism": "Rat", "refseq_name": "transcription factor IIIA", "refseq_ac": "NP_001107042", "gene_names_uniprotkb": "Gtf3a", "gene_names_refseq": "Gtf3a", "protein_names_uniprotkb": "Transcription factor IIIA; TFIIIA", "protein_names_refseq": "TFIIIA; factor A; transcription factor IIIA", "tax_id": 10116, "disease": "", "pathway": " (rno:246299); (R-RNO-76061)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11814676", "class_list": "", "function": "Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (By similarity). Also binds the transcribed 5S RNA's (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0008097 5S rRNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006351 DNA-templated transcription;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VHT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62769-1", "uniprot_id": "UN13B_RAT", "mass": 184063.0, "length": 1622, "protein_name": "Protein unc-13 homolog B", "gene_name": "Unc13b", "organism": "Rat", "refseq_name": "protein unc-13 homolog B isoform b", "refseq_ac": "NP_074053", "gene_names_uniprotkb": "Unc13b; Unc13h2", "gene_names_refseq": "Munc13-2; Unc13b; Unc13h2", "protein_names_uniprotkb": "Protein unc-13 homolog B; Munc13-2", "protein_names_refseq": "protein unc-13 homolog B isoform b; protein unc-13 homolog B", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:64830); (R-RNO-181429); (R-RNO-181430); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "11343654;31936129;7559667;9697857;9895278", "class_list": "", "function": "Delineating the Molecular Basis of the CalmodulinbMunc13-2 Interaction by Cross-Linking/Mass Spectrometry-Evidence for a Novel CaM Binding Motif in bMunc13-2. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WV40", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060384 innervation;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0090382 phagosome maturation;GO:0007528 neuromuscular junction development;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62769-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUW8-1", "uniprot_id": "ST1C2_RAT", "mass": 34731.0, "length": 296, "protein_name": "Sulfotransferase 1C2", "gene_name": "Sult1c2a; Sult1c2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sult1c2a; Sult1c2; LOC120093086; LOC120094625; Sult1c2a; Sultk1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sulfotransferase 1C2; 2.8.2.1; ST1C2; Sulfotransferase K1; rSULT1C2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171072); (R-RNO-156584)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10872834;12164856;39194960", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds (PubMed:10872834). Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:10872834). Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration (PubMed:39194960). Catalyzes the sulfation of the carcinogenic N-hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LZL1;Q3ZAV3", "ec_number_list": "2.8.2.-;2.8.2.14;2.8.2.2;2.8.2.1", "go_molecular_function": "GO:0004062 aryl sulfotransferase activity;GO:0051922 cholesterol sulfotransferase activity;GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005764 lysosome", "go_biological_process": "GO:0051923 sulfation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WUW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYM2-1", "uniprot_id": "TEKT2_RAT", "mass": 50296.0, "length": 430, "protein_name": "Tektin-2", "gene_name": "Tekt2", "organism": "Rat", "refseq_name": "tektin-2", "refseq_ac": "NP_001011977", "gene_names_uniprotkb": "Tekt2", "gene_names_refseq": "Tekt2", "protein_names_uniprotkb": "Tektin-2; Tektin-t; Testicular tektin", "protein_names_refseq": "tektin 2 (testicular); tektin-2; tektin-t; testicular tektin", "tax_id": 10116, "disease": "", "pathway": " (rno:298532)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20822404", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TEKT2 may function as an ODF-affiliated molecule required for flagellum stability and sperm motility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0005815 microtubule organizing center;GO:0036126 sperm flagellum;GO:0005814 centriole;GO:0097228 sperm principal piece", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FW3-1", "uniprot_id": "ST7L_RAT", "mass": 63334.0, "length": 559, "protein_name": "Suppressor of tumorigenicity 7 protein-like", "gene_name": "St7l", "organism": "Rat", "refseq_name": "suppressor of tumorigenicity 7 protein-like", "refseq_ac": "NP_001007640", "gene_names_uniprotkb": "St7l", "gene_names_refseq": "St7l", "protein_names_uniprotkb": "Suppressor of tumorigenicity 7 protein-like", "protein_names_refseq": "suppressor of tumorigenicity 7 protein-like; suppressor of tumorigenicity protein 7-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:295344)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0016020 membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0030308 negative regulation of cell growth;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYQ4-1", "uniprot_id": "TM109_RAT", "mass": 26242.0, "length": 243, "protein_name": "Voltage-gated monoatomic cation channel TMEM109", "gene_name": "Tmem109", "organism": "Rat", "refseq_name": "voltage-gated monoatomic cation channel TMEM109 precursor", "refseq_ac": "NP_001007737", "gene_names_uniprotkb": "Tmem109", "gene_names_refseq": "Tmem109", "protein_names_uniprotkb": "Voltage-gated monoatomic cation channel TMEM109; Transmembrane protein 109", "protein_names_refseq": "mg23; mitsugumin-23; voltage-gated monoatomic cation channel TMEM109 precursor; voltage-gated monoatomic cation channel TMEM109", "tax_id": 10116, "disease": "", "pathway": " (rno:361732)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "28630041;29393594", "class_list": "", "function": "Data, including data from studies in vesicles of knockout mice, suggest pathophysiological levels of Zn2+ (>2nM) cause dysregulation of RyR2 opening; in sarcoplasmic reticulum, RyR2 are not the only Ca2+-channels regulated by Zn2+; in cardiomyocytes exposed to ischemic/hypoxic conditions, intracellular Zn2+ levels are elevated, coinciding with increased MG23 expression. (RyR2 = ryanodine receptor 2; MG23 = mitsugumin 23), [RefSeq, PubMed]; Functions as a voltage-gated monoatomic cation channel permeable to both potassium and calcium (By similarity). Plays a role in the cellular response to DNA damage (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.8.-.-", "go_molecular_function": "GO:0022843 voltage-gated monoatomic cation channel activity", "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane;GO:0034702 monoatomic ion channel complex;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043069 negative regulation of programmed cell death;GO:0071480 cellular response to gamma radiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62880-1", "uniprot_id": "TAF9B_RAT", "mass": 28220.0, "length": 258, "protein_name": "Transcription initiation factor TFIID subunit 9B", "gene_name": "Taf9b", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Taf9b; Dn7; Taf9l", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 9B; DN-7; Neuronal cell death-related gene in neuron 7; Transcription initiation factor TFIID subunit 9-like; Transcription-associated factor TAFII31L", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171152); (R-RNO-5689880); (R-RNO-674695); (R-RNO-6804756); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-76042)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "29393594;9168994", "class_list": "", "function": "Essential for cell viability. TAF9 and TAF9L are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5EAN8", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005669 transcription factor TFIID complex;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030307 positive regulation of cell growth;GO:0043066 negative regulation of apoptotic process;GO:0050821 protein stabilization;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62880-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P6S0-1", "uniprot_id": "SNP47_RAT", "mass": 47042.0, "length": 419, "protein_name": "Synaptosomal-associated protein 47", "gene_name": "Snap47", "organism": "Rat", "refseq_name": "synaptosomal-associated protein 47", "refseq_ac": "NP_955421", "gene_names_uniprotkb": "Snap47", "gene_names_refseq": "RGD735194; SNAP-47; Snap47", "protein_names_uniprotkb": "Synaptosomal-associated protein 47; SNAP-47; Synaptosomal-associated 47 kDa protein", "protein_names_refseq": "synaptosomal-associated 47 kDa protein; synaptosomal-associated protein 47; synaptosomal-associated protein, 47", "tax_id": 10116, "disease": "", "pathway": " (rno:303183)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16621800", "class_list": "", "function": "May play a role in intracellular membrane fusion., [UniProtKB, UniProtKB, UniProtKB]; SNAP-47, a novel Qbc-SNARE with ubiquitous expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006887 exocytosis;GO:0060291 long-term synaptic potentiation;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane;GO:0016082 synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P6S0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923Y0-1", "uniprot_id": "TAA8C_RAT", "mass": 38016.0, "length": 344, "protein_name": "Trace amine-associated receptor 8c", "gene_name": "Taar8c", "organism": "Rat", "refseq_name": "trace amine-associated receptor 8c", "refseq_ac": "NP_783190", "gene_names_uniprotkb": "Taar8c; Ta10; Tar10; Trar10", "gene_names_refseq": "Ta10; Taar8c", "protein_names_uniprotkb": "Trace amine-associated receptor 8c; TaR-10; TaR-8c; Trace amine receptor 10; Trace amine receptor 8c", "protein_names_refseq": "taR-10; taR-8c; trace amine receptor 10; trace amine receptor 8c; trace amine-associated receptor 8c", "tax_id": 10116, "disease": "", "pathway": " (rno:319105); (R-RNO-375280)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11459929;22545963", "class_list": "", "function": "Olfactory receptor activated by trace amines, such as N-methylpiperidine and N,N-dimethylcyclohexylamine (PubMed:22545963). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:22545963). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q923Y0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99P85-1", "uniprot_id": "RETNA_RAT", "mass": 12076.0, "length": 111, "protein_name": "Resistin-like alpha", "gene_name": "Retnla", "organism": "Rat", "refseq_name": "resistin-like alpha precursor", "refseq_ac": "NP_445785", "gene_names_uniprotkb": "Retnla; Fizz1", "gene_names_refseq": "Himf; Retnla", "protein_names_uniprotkb": "Resistin-like alpha; Cysteine-rich secreted protein FIZZ1; RELMalpha", "protein_names_refseq": "RELMalpha; cysteine-rich secreted protein FIZZ1; hypoxia-induced mitogenic factor; resistin-like alpha precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:81712)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11209052;19136574;21426641;24040449;27492801;28348014", "class_list": "", "function": "FIZZ1 could enhance angiogenesis of rat aortic endothelial cells by up-regulating Gng8 and Atg9a. Publication Status: Online-Only, [RefSeq, PubMed]; FIZZl and NOTCH1 may induce an increase in a-SMA expression. FIZZl and NOTCH1 play a critical role in the process of airway remodeling., [RefSeq, PubMed]; HIMF represents a critical cytokine-like growth factor in the development of pulmonary hypertension., [RefSeq, PubMed]; Probable hormone. Plays a role in pulmonary vascular remodeling (By similarity)., [UniProtKB]; RELMalpha augments inflammatory activity by increasing inflammatory cytokine release., [RefSeq, PubMed]; The binding of HIMF enhanced the activity of extracellular CaSR and mediated hypoxia-evoked proliferation of pulmonary artery smooth cells and the development of pulmonary vascular remodeling and pulmonary hypertension, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99P85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63630-1", "uniprot_id": "RHOX5_RAT", "mass": 22850.0, "length": 211, "protein_name": "Homeobox protein Rhox5", "gene_name": "Ndufa1; Rhox5; Rnf113a1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ndufa1; Rhox5; Rnf113a1; Pem", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Rhox5; Homeobox protein Pem; Placenta and embryonic expression protein; Reproductive homeobox on chromosome X 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "nonphotosensitive trichothiodystrophy 5 (Disease Ontology:DOID:0111868); nuclear type mitochondrial complex I deficiency 12 (Disease Ontology:DOID:0112099)", "pathway": " (rno:24631); (rno:363441)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;8663309;8786129", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB]; Transcription factor required for differentiation of embryonic stem cells (ESCs) into primordial germ cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97736;Q4TU77", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071005 U2-type precatalytic spliceosome;GO:0071018 U12-type catalytic step 2 spliceosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0070100 negative regulation of chemokine-mediated signaling pathway;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6J2U6-1", "uniprot_id": "RN114_RAT", "mass": 25664.0, "length": 229, "protein_name": "E3 ubiquitin-protein ligase RNF114", "gene_name": "Rnf114", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF114", "refseq_ac": "NP_001001517", "gene_names_uniprotkb": "Rnf114; Zfp313; Znf313", "gene_names_refseq": "Rnf114; Zfp313; Znf313", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF114; 2.3.2.27; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; Zinc finger protein 313", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF114; RING-type E3 ubiquitin transferase RNF114; zinc finger protein 313", "tax_id": 10116, "disease": "male infertility (Disease Ontology:DOID:12336)", "pathway": " (rno:362277); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Also acts as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G096", "ec_number_list": "2.3.2.26;2.3.2.32;2.3.2.31;2.3.2.23;2.3.2.27;2.3.2.34;2.3.2.24;2.3.2.-;2.3.2.25", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0019900 kinase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0010957 negative regulation of vitamin D biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6J2U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923Y4-1", "uniprot_id": "TAA7H_RAT", "mass": 40074.0, "length": 358, "protein_name": "Trace amine-associated receptor 7h", "gene_name": "Taar7h", "organism": "Rat", "refseq_name": "trace amine-associated receptor 7h", "refseq_ac": "NP_783177", "gene_names_uniprotkb": "Taar7h; Ta6; Tar6; Trar6", "gene_names_refseq": "Ta6; Taar7h", "protein_names_uniprotkb": "Trace amine-associated receptor 7h; TaR-6; TaR-7h; Trace amine receptor 6; Trace amine receptor 7h", "protein_names_refseq": "taR-6; taR-7h; trace amine receptor 6; trace amine receptor 7h; trace amine-associated receptor 7h", "tax_id": 10116, "disease": "", "pathway": " (rno:294130)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11459929;17556730;22545963", "class_list": "", "function": "Expression of Taar family members is limited to specific tissue subpopulations and developmental stages in mouse., [RefSeq, PubMed]; Olfactory receptor specific for N,N-dimethylalkylamines trace amines (PubMed:22545963). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:22545963). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q923Y4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H15-1", "uniprot_id": "RMD3_RAT", "mass": 52312.0, "length": 471, "protein_name": "Regulator of microtubule dynamics protein 3", "gene_name": "Rmdn3", "organism": "Rat", "refseq_name": "regulator of microtubule dynamics protein 3", "refseq_ac": "NP_001014068", "gene_names_uniprotkb": "Rmdn3; Fam82a2; Fam82c", "gene_names_refseq": "Fam82a2; Fam82c; Ptpip51; RGD1308697; Rmd-3; Rmdn3", "protein_names_uniprotkb": "Regulator of microtubule dynamics protein 3; Protein FAM82A2; Protein FAM82C; RMD-3", "protein_names_refseq": "family with sequence similarity 82, member A2; family with sequence similarity 82, member C; protein tyrosine phosphatase-interacting protein 51; regulator of microtubule dynamics protein 3-like; regulator of microtubule dynamics protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:311328)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17551746;22673903;25999297;29393594;30841933", "class_list": "", "function": "Immunostaining showed expression of PTPIP51 protein in distinct non-parenchymal cells., [RefSeq, PubMed]; Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity)., [UniProtKB]; Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis., [UniProtKB, UniProtKB]; Results showed that PTPIP51 expressed in post-natal retina contributes to the final differentiation of photoreceptors, probably by participating in the complex formation of the photoreceptor segments, [RefSeq, PubMed]; VAPB-PTPIP51 mitochondrial tethering proteins are present in synapses and regulate synaptic activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044232 organelle membrane contact site;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0030154 cell differentiation;GO:0006874 intracellular calcium ion homeostasis;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q66H15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BNA7-1", "uniprot_id": "EIF3I_RAT", "mass": 36461.0, "length": 325, "protein_name": "Eukaryotic translation initiation factor 3 subunit I", "gene_name": "Eif3i", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 3 subunit I", "refseq_ac": "NP_001108507", "gene_names_uniprotkb": "Eif3i; Dcdc2b; EIF3I; EIF3S2; Eif3s2", "gene_names_refseq": "Eif3i; Eif3s2; TRIP-1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 subunit 2; eIF-3-beta; eIF3 p36; eIF3i", "protein_names_refseq": "eIF-3-beta; eIF3 p36; eukaryotic translation initiation factor 3 subunit 2; eukaryotic translation initiation factor 3 subunit I", "tax_id": 10116, "disease": "", "pathway": " (rno:682390); (R-RNO-156827); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0045202 synapse;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIG8-1", "uniprot_id": "STRAP_RAT", "mass": 38456.0, "length": 350, "protein_name": "Serine-threonine kinase receptor-associated protein", "gene_name": "Strap", "organism": "Rat", "refseq_name": "serine-threonine kinase receptor-associated protein", "refseq_ac": "NP_001011969", "gene_names_uniprotkb": "Strap; Unrip", "gene_names_refseq": "Strap", "protein_names_uniprotkb": "Serine-threonine kinase receptor-associated protein; UNR-interacting protein", "protein_names_refseq": "UNR-interacting protein; serine-threonine kinase receptor-associated protein-like; serine-threonine kinase receptor-associated protein", "tax_id": 10116, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); adenocarcinoma (Disease Ontology:DOID:299); squamous cell neoplasm (Disease Ontology:DOID:3168); lung carcinoma (Disease Ontology:DOID:3905); large cell carcinoma (Disease Ontology:DOID:4552)", "pathway": " (rno:297699); (R-RNO-2173788)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;24577865;32373981", "class_list": "", "function": "STRAP reduces endoplasmic reticulum stress and apoptosis in cardiomyocytes and attenuates myocardial ischemia-reperfusion injury by activating PI3K/PDK1/Akt signaling pathway., [RefSeq, PubMed]; Study found that STRAP and Smad7 are significantly decreased in the pilocarpine-induced epileptic rats compared with the normal rats, [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005102 signaling receptor binding;GO:1990447 U2 snRNP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032797 SMN complex;GO:0034719 SMN-Sm protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0030277 maintenance of gastrointestinal epithelium;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5XIG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W87-1", "uniprot_id": "ROBO4_RAT", "mass": 102580.0, "length": 961, "protein_name": "Roundabout homolog 4", "gene_name": "Robo4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Robo4; LOC100911068", "gene_names_refseq": "", "protein_names_uniprotkb": "Roundabout homolog 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "aortic valve disease 3 (Disease Ontology:DOID:0080977); pre-eclampsia (Disease Ontology:DOID:10591); transient cerebral ischemia (Disease Ontology:DOID:224); thyroid gland carcinoma (Disease Ontology:DOID:3963)", "pathway": " (rno:100911068)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0061028 establishment of endothelial barrier;GO:0001525 angiogenesis;GO:0030336 negative regulation of cell migration;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80W87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6RUV5-1", "uniprot_id": "RAC1_RAT", "mass": 21450.0, "length": 192, "protein_name": "Ras-related C3 botulinum toxin substrate 1", "gene_name": "Rac1; Rac3", "organism": "Rat", "refseq_name": "ras-related C3 botulinum toxin substrate 1", "refseq_ac": "NP_599193", "gene_names_uniprotkb": "Rac1; Rac3; Rac3; Rac", "gene_names_refseq": "Rac1", "protein_names_uniprotkb": "Ras-related C3 botulinum toxin substrate 1; 3.6.5.2; p21-Rac1", "protein_names_refseq": "p21-Rac1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); ras-related C3 botulinum toxin substrate 1; rho family, small GTP binding protein Rac1", "tax_id": 10116, "disease": "colon adenoma (Disease Ontology:DOID:0050912); colorectal carcinoma (Disease Ontology:DOID:0080199); autosomal dominant intellectual developmental disorder 48 (Disease Ontology:DOID:0080235); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); colon adenocarcinoma (Disease Ontology:DOID:234); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); gastric adenocarcinoma (Disease Ontology:DOID:3717); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); gallbladder carcinoma (Disease Ontology:DOID:4948); kidney disease (Disease Ontology:DOID:557); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:363875); (R-RNO-114604); (R-RNO-1257604); (R-RNO-1433557); (R-RNO-193648); (R-RNO-2029482); (R-RNO-2424491); (R-RNO-2871796); (R-RNO-389359); (R-RNO-3928662); (R-RNO-3928664); (R-RNO-3928665); (R-RNO-399954); (R-RNO-4086400); (R-RNO-416550); (R-RNO-418885); (R-RNO-4420097); (R-RNO-445144); (R-RNO-5218920); (R-RNO-5625740); (R-RNO-5625900); (R-RNO-5625970); (R-RNO-5626467); (R-RNO-5627123); (R-RNO-5663213); (R-RNO-5663220); (R-RNO-5668599); (R-RNO-5687128); (R-RNO-6798695); (R-RNO-6811558); (R-RNO-8849471); (R-RNO-8875555); (R-RNO-9013149); (R-RNO-9013423); (R-RNO-9032759); (R-RNO-9748787); (R-RNO-983231); (R-RNO-9958810); (R-RNO-9958825)", "pathway_count": 39, "publication_count": 17, "publication_id_list": "12695502;15800193;16040606;16549782;16973299;19029984;20696765;22128169;24089484;25284783;25498153;36562344;36938611;37598223;37735499;37984604;38843836", "class_list": "", "function": "Inhibition of spinal Rac1 attenuates chronic inflammatory pain by regulating the activation of astrocytes., [RefSeq, PubMed]; Interfering with Rac1-activation during neonatal monocyte-macrophage differentiation influences the inflammatory responses of M1 macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA1945p attenuates hypoxia/reoxygenationinduced apoptosis in H9C2 cardiomyocytes by inhibiting the overactivation of RAC1 protein., [RefSeq, PubMed]; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:16040606, PubMed:16549782). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (By similarity). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:16040606). In glioma cells, promotes cell migration and invasion (PubMed:20696765). In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning (PubMed:19029984). Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). In neurons, is involved in dendritic spine formation and synaptic plasticity (PubMed:25498153). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (PubMed:12695502). In synapses, may mediate the regulation of F-actin cluster formation performed by SHANK3 (PubMed:24089484). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (PubMed:25284783). Required for DSG3 translocation to cell-cell junctions, DSG3-mediated organization of cortical F-actin bundles and anchoring of actin at cell junctions; via interaction with DSG3 (By similarity). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats. Erratum:[Mol Pain. 2023 Jan-Dec;19:17448069231182501. doi: 10.1177/17448069231182501. PMID: 37608691], [RefSeq, PubMed]; Time-dependent inhibition of Rac1 in the VTA enhances long-term aversive memory: implications in active forgetting mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;2.7.11.1;2.7.10.1;2.7.1.153;2.7.1.137;2.3.2.31;2.7.10.2;3.6.1.1;2.7.1.154;3.6.5.-;3.6.5.3;2.3.2.27;2.3.2.26;3.1.3.86;3.1.3.56;3.1.3.36;3.6.1.29;3.4.16.2;2.7.11.13;1.3.1.70;3.6.5.5;3.6.1.5;3.1.3.48;3.4.24.11;3.1.4.11;3.4.11.-;3.4.11.2;2.7.11.24;3.6.4.-;3.1.4.4;3.6.4.10;3.6.1.-;2.3.1.-;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.2.2.6;7.6.2.2;7.6.2.3;3.1.3.-;1.6.3.-;3.6.5.4;3.2.1.20;5.6.1.3;3.2.1.31", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0001891 phagocytic cup", "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0010762 regulation of fibroblast migration;GO:0021799 cerebral cortex radially oriented cell migration;GO:2000386 positive regulation of ovarian follicle development;GO:0046425 regulation of receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q6RUV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESP7-1", "uniprot_id": "ATS4_RAT", "mass": 68385.0, "length": 630, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 4", "gene_name": "Adamts4", "organism": "Rat", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 4", "refseq_ac": "NP_076449", "gene_names_uniprotkb": "Adamts4", "gene_names_refseq": "Adamts4", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 4; 3.4.24.82; ADAM-TS 4; ADAM-TS4; ADAMTS-4; Aggrecanase-1", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS 4; ADAM-TS4; ADAMTS-4; Aggrecanase; a disintegrin and metallopeptidase with thrombospondin motifs 4; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4; aggrecanase-1", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); rheumatoid arthritis (Disease Ontology:DOID:7148); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (rno:66015); (R-RNO-1474228); (R-RNO-5173214)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10961658;16200461;37424113", "class_list": "", "function": "Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover. Also cleaves COMP. May play an important role in the destruction of aggrecan in arthritic diseases., [UniProtKB, UniProtKB]; Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1-4-8 during the three trimesters of rat pregnancy at the maternal-fetal interface., [RefSeq, PubMed]; This study suggests that dental pulp cells, odontoblasts, cementoblasts, cementocytes, periodontal ligament cells, osteoblasts and osteocytes may be involved in both production and degradation of versican with secreting ADAMTS1, ADAMTS4 and ADAMTS5., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESP6;Q9ESP8", "ec_number_list": "2.4.1.221;3.4.24.87;3.4.24.-;3.4.24.82", "go_molecular_function": "GO:0002020 protease binding;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016607 nuclear speck;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0042742 defense response to bacterium;GO:0030167 proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ESP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PD2-1", "uniprot_id": "RN138_RAT", "mass": 24072.0, "length": 209, "protein_name": "E3 ubiquitin-protein ligase RNF138", "gene_name": "Rnf138", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF138", "refseq_ac": "NP_446040", "gene_names_uniprotkb": "Rnf138; AABR07031480.1; RSD-4", "gene_names_refseq": "Rnf138; Rsd4; Trif", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF138; 2.3.2.27; RING finger protein 138; RING-type E3 ubiquitin transferase RNF138", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF138; RING-type E3 ubiquitin transferase RNF138; RSD-4; ring finger protein 138, E3 ubiquitin protein ligase", "tax_id": 10116, "disease": "", "pathway": " (rno:94196); (R-RNO-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32084554", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway., [UniProtKB, UniProtKB]; Ethanol extracts from Ilex pubescens promotes cerebral ischemic tolerance via modulation of TLR4-MyD88/TRIF signaling pathway in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.32;2.3.2.31;2.3.2.23;2.3.2.27;2.3.2.34;2.3.2.24;2.3.2.-;2.3.2.25", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0061630 ubiquitin protein ligase activity;GO:0003697 single-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098794 postsynapse;GO:0035861 site of double-strand break;GO:0098793 presynapse;GO:0005694 chromosome", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0016055 Wnt signaling pathway;GO:0016567 protein ubiquitination;GO:0000724 double-strand break repair via homologous recombination;GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99PD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQT1-1", "uniprot_id": "PDGFD_RAT", "mass": 42809.0, "length": 370, "protein_name": "Platelet-derived growth factor D", "gene_name": "Pdgfd", "organism": "Rat", "refseq_name": "platelet-derived growth factor D precursor", "refseq_ac": "NP_076452", "gene_names_uniprotkb": "Pdgfd; Iegf; Scdgfb", "gene_names_refseq": "Pdgfd; Scdgfb; rSCDGF-B", "protein_names_uniprotkb": "Platelet-derived growth factor D; Iris-expressed growth factor; PDGF-D; SCDGF-B; Spinal cord-derived growth factor B", "protein_names_refseq": "iris-expressed growth factor; platelet-derived growth factor D precursor; platelet-derived growth factor, D polypeptide; spinal cord-derived growth factor B; spinal-cord derived growth factor-B protein", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); prostatic hypertrophy (Disease Ontology:DOID:11132); atherosclerosis (Disease Ontology:DOID:1936); glomerulonephritis (Disease Ontology:DOID:2921); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:66018); (R-RNO-186797)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11162582;11850188;12937299;15611105;25148874;30483778", "class_list": "", "function": "Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis (By similarity). May play an important role in control of lens epithelial cell proliferation. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix., [UniProtKB, PubMed, PubMed]; Observations indicated that PDGF can contribute to the development of cardiac interstitial fibrosis in the noninfarcted myocardium, but does not alter scar formation in the infarcted myocardium., [RefSeq, PubMed]; PDGFD is expressed in the eye and has a key role in control of lens epithelial cell proliferation, [RefSeq, PubMed]; PDGFD promotes the angiogenic capacity of EPCs., [RefSeq, PubMed]; The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EQT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R085-1", "uniprot_id": "UBP15_RAT", "mass": 109255.0, "length": 952, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 15", "gene_name": "Usp15", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 15 isoform 1", "refseq_ac": "NP_660185", "gene_names_uniprotkb": "Usp15; ubp109", "gene_names_refseq": "Ubp109; Usp15", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 15; 3.4.19.12; Deubiquitinating enzyme 15; Ubiquitin carboxyl-terminal hydrolase of 109 kDa; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15", "protein_names_refseq": "deubiquitinating enzyme 15; deubiquitinating enzyme Ubp109; ubiquitin carboxyl-terminal hydrolase 15 isoform 1; ubiquitin carboxyl-terminal hydrolase 15; ubiquitin carboxyl-terminal hydrolase of 109 kDa; ubiquitin specific protease 15; ubiquitin thioesterase 15; ubiquitin-specific-processing protease 15", "tax_id": 10116, "disease": "chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (rno:171329); (R-RNO-5689880)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10880343;22673903;31933062;34088152;35478295;36635430", "class_list": "", "function": "Alleviative effect of microRNA-497 on diabetic neuropathic pain in rats in relation to decreased USP15., [RefSeq, PubMed]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB]; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery. Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9., [UniProtKB, UniProtKB]; Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells., [RefSeq, PubMed]; USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway., [RefSeq, PubMed]; USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PSP9", "ec_number_list": "2.3.2.26;2.7.11.30;3.4.19.12", "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity;GO:0005160 transforming growth factor beta receptor binding;GO:0046332 SMAD binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0051252 regulation of RNA metabolic process;GO:1905035 negative regulation of antifungal innate immune response;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R085-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IMA3-1", "uniprot_id": "RSLBA_RAT", "mass": 26975.0, "length": 242, "protein_name": "Ras-like protein family member 11A", "gene_name": "Rasl11a", "organism": "Rat", "refseq_name": "ras-like protein family member 11A", "refseq_ac": "NP_001388042", "gene_names_uniprotkb": "Rasl11a", "gene_names_refseq": "Rasl11a", "protein_names_uniprotkb": "Ras-like protein family member 11A; 3.6.5.2", "protein_names_refseq": "ras-like protein family member 11A", "tax_id": 10116, "disease": "", "pathway": " (rno:304268)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15033445", "class_list": "", "function": "Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045943 positive regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IMA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CH27-1", "uniprot_id": "RCAN2_RAT", "mass": 21991.0, "length": 197, "protein_name": "Calcipressin-2", "gene_name": "Rcan2", "organism": "Rat", "refseq_name": "calcipressin-2", "refseq_ac": "NP_783168", "gene_names_uniprotkb": "Rcan2; Dscr1l1; Zaki4", "gene_names_refseq": "Dcip2; Dscr1l1; Rcan2; Zaki-4", "protein_names_uniprotkb": "Calcipressin-2; Calcineurin inhibitory protein ZAKI-4; Down syndrome candidate region 1-like protein 1; Regulator of calcineurin 2", "protein_names_refseq": "Down syndrome critical region gene 1-like 1; Down syndrome critical region gene1-like 1; calcineurin inhibitory protein ZAKI-4; calcipressin-2; down syndrome candidate region 1-like protein 1", "tax_id": 10116, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (rno:140666)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CH26", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007219 Notch signaling pathway;GO:0019722 calcium-mediated signaling;GO:0007614 short-term memory;GO:0031987 locomotion involved in locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CH27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923Y9-1", "uniprot_id": "TAAR1_RAT", "mass": 38021.0, "length": 332, "protein_name": "Trace amine-associated receptor 1", "gene_name": "Taar1", "organism": "Rat", "refseq_name": "trace amine-associated receptor 1", "refseq_ac": "NP_599155", "gene_names_uniprotkb": "Taar1; Ta1; Tar1; Trar1", "gene_names_refseq": "Taar1; Tar1; Trar1; taR-1", "protein_names_uniprotkb": "Trace amine-associated receptor 1; TaR-1; Trace amine receptor 1", "protein_names_refseq": "trace amine-associated receptor 1", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:113914); (R-RNO-375280)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11459929;11723224;15718104;15955414;21073468;23072560;26372541;27544651;28123023;35346791", "class_list": "", "function": "Intracellular G protein-coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA), p-tyramine (p-TYR), trimethylamine (TMA), octopamine and tryptamine (PubMed:15718104). Also functions as a receptor for various drugs and psychoactive substances, such as amphetamine and methamphetamine (By similarity). Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin (By similarity). Expressed in both the central and peripheral nervous system: TAAR1 activation regulates the activity of several neurotransmitter signaling pathways by (1) decreasing the basal firing rates of the neurons involved and by (2) lowering the sensitivity of receptors to neurotransmitters (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). TAAR1 is coupled with different G(i)/G(o)-, G(s)- or G(q)/G(11) classes of G alpha proteins depending on the ligand (By similarity). CAD-binding is coupled to G(i)/G(o) G alpha proteins and mediates inhibition of adenylate cyclase activity (By similarity). T1AM- or beta-PEA-binding is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). CHA- or IAA-binding is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (By similarity). TMA-binding is coupled with all three G(i)/G(o)-, G(s)- or G(q)/G(11) G alpha protein subtypes (By similarity)., [UniProtKB, PubMed, UniProtKB]; Overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity. [review] Review article, [RefSeq, PubMed]; Pretreatment with the trace amine-associate receptor 1 (TAAR1) antagonist EPPTB (5mg/kg, i.v.) blocked the inhibitory effect of LSD on VTA DA neurons., [RefSeq, PubMed]; Results demonstrate that betaArr2 signaling may be an important pathway for TAAR1 function and that the activation of the TAAR1-D2R complex negatively modulates GSK3b signaling, [RefSeq, PubMed]; TAAR1 in different subregions of the mesocorticolimbic system contributes to reinstatement of cocaine-seeking behavior., [RefSeq, PubMed]; The Tyramine highly concentrated in the median eminence of the mediobasal hypothalamus, in which its physiological function on prolactin release has been demonstrated., [RefSeq, PubMed]; The different functionality of rat Taar subtypes 1 and 4 mainly correlates with receptor's cell surface expression rather than with specific amino acid residues involved in ligand binding specificity., [RefSeq, PubMed]; Trace amine-associated receptor 1 modulates motor hyperactivity, cognition, and anxiety-like behavior in an animal model of ADHD., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5QD26;Q8VHQ5", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001594 trace-amine receptor activity;GO:0008227 G protein-coupled amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0141163 positive regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q923Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GQP4-1", "uniprot_id": "RAB31_RAT", "mass": 21500.0, "length": 195, "protein_name": "Ras-related protein Rab-31", "gene_name": "Rab31", "organism": "Rat", "refseq_name": "ras-related protein Rab-31", "refseq_ac": "NP_659562", "gene_names_uniprotkb": "Rab31", "gene_names_refseq": "Rab0; Rab31", "protein_names_uniprotkb": "Ras-related protein Rab-31; 3.6.5.2; GTP-binding protein Rab0", "protein_names_refseq": "GTP-binding protein Rab0; monomeric GTP-binding protein; ras-related protein Rab-31", "tax_id": 10116, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (rno:246324); (R-RNO-6798695); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11746448;17678623;19345684;19725050;19795375;21849477", "class_list": "", "function": "A developmental stage survey of the rat brain by Western immunoblot analysis indicated Rab22B presence at several stages of embryonic and postnatal development., [RefSeq, PubMed]; Data demonstrate that Rab31 is required for transport of mannose 6-phosphate receptors from the trans-Golgi network to endosomes and for the Golgi/TGN organization., [RefSeq, PubMed]; The data provide the first evidence for Rab22 (also known as Rab22b, Rab31) as a positive regulator of nerve growth factor (NGF) signal transduction and cell differentiation., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JK74", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;3.1.3.48;3.4.24.11;3.4.11.-;3.4.11.2;2.5.1.60;3.6.1.-;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0090382 phagosome maturation;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0031623 receptor internalization;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6GQP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66MI6-1", "uniprot_id": "T10IP_RAT", "mass": 59788.0, "length": 536, "protein_name": "Testis-specific protein 10-interacting protein", "gene_name": "Tsga10ip", "organism": "Rat", "refseq_name": "testis-specific protein 10-interacting protein isoform 1", "refseq_ac": "NP_001004278", "gene_names_uniprotkb": "Tsga10ip", "gene_names_refseq": "Tsga10ip", "protein_names_uniprotkb": "Testis-specific protein 10-interacting protein; Tsga10-interacting protein", "protein_names_refseq": "fibrous sheath protein; testis-specific protein 10-interacting protein isoform 1; testis-specific protein 10-interacting protein; tsga10-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:361707)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QRC4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66MI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z221-1", "uniprot_id": "PMFBP_RAT", "mass": 113523.0, "length": 971, "protein_name": "Polyamine-modulated factor 1-binding protein 1", "gene_name": "Pmfbp1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pmfbp1; Odf3", "gene_names_refseq": "", "protein_names_uniprotkb": "Polyamine-modulated factor 1-binding protein 1; Outer dense fiber protein 3; PMF-1-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "spermatogenic failure 31 (Disease Ontology:DOID:0111922); male infertility (Disease Ontology:DOID:12336)", "pathway": " (rno:171414)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11774381", "class_list": "", "function": "Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0061827 sperm head;GO:0005737 cytoplasm;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0007010 cytoskeleton organization;GO:0032880 regulation of protein localization;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z221-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVK3-1", "uniprot_id": "PECR_RAT", "mass": 32433.0, "length": 303, "protein_name": "Peroxisomal trans-2-enoyl-CoA reductase", "gene_name": "Pecr", "organism": "Rat", "refseq_name": "peroxisomal trans-2-enoyl-CoA reductase", "refseq_ac": "NP_579833", "gene_names_uniprotkb": "Pecr", "gene_names_refseq": "Pecr; TERP", "protein_names_uniprotkb": "Peroxisomal trans-2-enoyl-CoA reductase; 1.3.1.38; PX-2,4-DCR1; Peroxisomal 2,4-dienoyl-CoA reductase; RLF98; TERP", "protein_names_refseq": "PX-2,4-DCR1; RLF98; perosisomal 2-enoyl-CoA reductase; peroxisomal 2,4-dienoyl-CoA reductase; peroxisomal trans-2-enoyl-CoA reductase", "tax_id": 10116, "disease": "", "pathway": " (rno:113956); (R-RNO-389599); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10561551;23486364", "class_list": "", "function": "Data indicate that 2,4-dienoyl-CoA reductase and hydroxymethylglutaryl-CoA synthase (HMGCS2) were upregulated in alcohol-fed rats., [RefSeq, PubMed]; Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.3.15;1.2.3.5;3.4.21.-;2.3.2.27;1.4.3.1;1.4.3.3;3.1.2.2;3.1.2.-;1.11.1.6;1.3.3.6;2.6.1.51;2.6.1.44;2.3.1.137;2.3.1.176;2.3.1.16;2.3.1.155;2.3.2.36;2.5.1.18;3.4.24.56;1.1.1.42;5.1.99.4;4.1.3.4;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;1.14.13.39;3.4.21.53;5.3.3.8;5.3.3.21;3.1.2.27;2.3.1.65;3.6.1.-;3.6.1.77;2.3.1.7;4.1.2.63;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;1.1.1.300;1.1.1.184;4.1.1.9;2.3.1.42;1.3.1.38;2.7.4.6;1.3.1.124", "go_molecular_function": "GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0033306 phytol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WVK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76LT8-1", "uniprot_id": "UBP48_RAT", "mass": 118787.0, "length": 1036, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 48", "gene_name": "Usp48", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Usp48", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 48; 3.4.19.12; Deubiquitinating enzyme 48; Synaptic ubiquitin-specific protease; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48; synUSP", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 85 (Disease Ontology:DOID:0070605)", "pathway": " (rno:362636); (R-RNO-5689880)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14535949;22673903", "class_list": "", "function": "Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites (PubMed:14535949). Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability. In the context of H. pylori infection, stabilizes nuclear RELA through deubiquitination, thereby promoting the transcriptional activity of RELA to prolong TNFAIP3 de novo synthesis. Consequently, TNFAIP3 suppresses caspase activity and apoptotic cell death. Also functions in the modulation of the ciliary and synaptic transport as well as cytoskeleton organization, which are key for photoreceptor function and homeostasis. To achieve this, stabilizes the levels of the retinal degeneration-associated proteins ARL3 and UNC119 using distinct mechanisms. Plays a positive role in pyroptosis by stabilizing gasdermin E/GSDME through removal of its 'Lys-48'-linked ubiquitination., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;3.4.19.12", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q76LT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZG0-1", "uniprot_id": "RIC8B_RAT", "mass": 58390.0, "length": 520, "protein_name": "Chaperone Ric-8B", "gene_name": "Ric8b", "organism": "Rat", "refseq_name": "chaperone Ric-8B isoform 1", "refseq_ac": "NP_783188", "gene_names_uniprotkb": "Ric8b", "gene_names_refseq": "Ric8b", "protein_names_uniprotkb": "Chaperone Ric-8B; Synembryn-B", "protein_names_refseq": "chaperone Ric-8B isoform 1; chaperone Ric-8B; heterotrimeric G protein guanine nucleotide exchange factor-like protein Ric-8B; resistance to inhibitors of cholinesterase 8 homolog B; resistance to inhibitors of cholinesterase 8B; synembryn-B", "tax_id": 10116, "disease": "", "pathway": " (rno:314681)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12509430;21467038;22673903;24585571;26966186", "class_list": "", "function": "Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Chaperone that specifically binds and folds nascent G(s) G-alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane. Also acts as a guanine nucleotide exchange factor (GEF) for G(s) proteins by stimulating exchange of bound GDP for free GTP. Acts as an important component for odorant signal transduction by mediating GNAL (G(olf)-alpha) folding, thereby promoting-dependent cAMP accumulation in olfactory sensory neurons., [UniProtKB, UniProtKB]; Overexpression of ARMS blocked NGF-mediated secretion, without affecting basal secretion, a decrease in ARMS resulted in potentiation. Similar effects were observed with synembryn-B, a protein that interacts directly with ARMS. Downstream of ARMS and synembryn-B are Galphaq and Trio proteins, which modulate the activity of Rac1 in response to NGF, [RefSeq, PubMed]; Results indicate that a functional N-terminus in C/EBPbeta-LAP* is required for interacting with SWI/SNF and for Ric-8B gene repression in osteoblasts., [RefSeq, PubMed]; Ric-8BFL-catalyzed nucleotide exchange probably proceeds in the forward direction to produce Galpha-GTP in cells., [RefSeq, PubMed]; Two mammalian homologs of the Caenorhabditis elegans protein Ric-8 were identified: Ric-8A (Ric-8/synembryn) and Ric-8B, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80ZG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYJ2-1", "uniprot_id": "RASA3_RAT", "mass": 96020.0, "length": 834, "protein_name": "Ras GTPase-activating protein 3", "gene_name": "Rasa3", "organism": "Rat", "refseq_name": "ras GTPase-activating protein 3", "refseq_ac": "NP_113762", "gene_names_uniprotkb": "Rasa3", "gene_names_refseq": "R-ras gap; Rasa3", "protein_names_uniprotkb": "Ras GTPase-activating protein 3; GAP1(IP4BP); Ins P4-binding protein; R-ras GAP", "protein_names_refseq": "GAP1(IP4BP); Ins P4-binding protein; R-Ras GTP activating protein; R-ras GTPase activating protein; ras GTPase-activating protein 3", "tax_id": 10116, "disease": "aplastic anemia (Disease Ontology:DOID:12449)", "pathway": " (rno:29372); (R-RNO-5658442)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18952607;22673903", "class_list": "", "function": "Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) (By similarity)., [UniProtKB]; Novel mechanism for dopamine D2S-induced inhibition of ERK1/2 and indicate that RASA3 links Galphai proteins to inhibit Gq-induced Ras/ERK1/2 activation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q09YN9", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0035556 intracellular signal transduction;GO:0034605 cellular response to heat;GO:0030168 platelet activation;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QYJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1C8-1", "uniprot_id": "RPGF3_RAT", "mass": 104559.0, "length": 926, "protein_name": "Rap guanine nucleotide exchange factor 3", "gene_name": "Rapgef3", "organism": "Rat", "refseq_name": "rap guanine nucleotide exchange factor 3 isoform 2", "refseq_ac": "NP_067722", "gene_names_uniprotkb": "Rapgef3; Epac1; Epac", "gene_names_refseq": "Epac; Rapgef3", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 3; EPAC 1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I", "protein_names_refseq": "Rap guanine nucleotide exchange factor (GEF) 3; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI); epac 1; exchange factor directly activated by cAMP 1; exchange protein directly activated by cAMP 1; rap guanine nucleotide exchange factor 3 isoform 2", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:59326); (R-RNO-354192); (R-RNO-381676); (R-RNO-392517); (R-RNO-422356)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "14622088;30551377;35702948;36768322;37753572;38985989;9856955", "class_list": "", "function": "Activation of Epac in the BLA disrupts reconsolidation and attenuates heroin-seeking behaviour., [RefSeq, PubMed]; Activation of Epac1-Akt signaling pathway., [RefSeq, PubMed]; EPAC1 and 2 inhibit K[+] currents via PLC/PKC and NOS/PKG pathways in rat ventricular cardiomyocytes., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Over-expression of Epac1 enhanced 5-HT7 nicotinic receptor-mediated activation of ERK proceeding through cAMP-dependent pathways utilizing cAMP-guanine nucleotide exchange factors rather than protein kinase A, [RefSeq, PubMed]; Unraveling the role of Epac1-SOCS3 signaling in the development of neonatal-CRD-induced visceral hypersensitivity in rats., [RefSeq, PubMed]; Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0044325 transmembrane transporter binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z1C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPJ0-1", "uniprot_id": "SSRA_RAT", "mass": 35629.0, "length": 319, "protein_name": "Translocon-associated protein subunit alpha", "gene_name": "Ssr1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ssr1; Ac2-238", "gene_names_refseq": "", "protein_names_uniprotkb": "Translocon-associated protein subunit alpha; Liver regeneration-related protein LRRG137; SSR-alpha; Signal sequence receptor subunit alpha; TRAP-alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:361233)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TPJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY41-1", "uniprot_id": "CC50A_RAT", "mass": 37173.0, "length": 328, "protein_name": "Cell cycle control protein 50A", "gene_name": "Tmem30a", "organism": "Rat", "refseq_name": "cell cycle control protein 50A isoform 2", "refseq_ac": "NP_001004248", "gene_names_uniprotkb": "Tmem30a; Cdc50a", "gene_names_refseq": "Cdc50a; Tmem30a", "protein_names_uniprotkb": "Cell cycle control protein 50A; P4-ATPase flippase complex beta subunit TMEM30A; Transmembrane protein 30A", "protein_names_refseq": "P4-ATPase flippase complex beta subunit TMEM30A; cell cycle control protein 50A isoform 2; cell cycle control protein 50A; transmembrane protein 30A", "tax_id": 10116, "disease": "", "pathway": " (rno:300857); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "24090084", "class_list": "", "function": "Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF). Can also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from ER to other membrane localizations (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0015247 aminophospholipid flippase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0045332 phospholipid translocation;GO:0036010 protein localization to endosome;GO:0006855 xenobiotic transmembrane transport;GO:0061092 positive regulation of phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AY41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXT7-1", "uniprot_id": "RBM42_RAT", "mass": 50266.0, "length": 478, "protein_name": "RNA-binding protein 42", "gene_name": "Rbm42", "organism": "Rat", "refseq_name": "RNA-binding protein 42", "refseq_ac": "NP_001014181", "gene_names_uniprotkb": "Rbm42", "gene_names_refseq": "RGD1306184; Rbm42", "protein_names_uniprotkb": "RNA-binding protein 42; RNA-binding motif protein 42", "protein_names_refseq": "RNA-binding protein 42", "tax_id": 10116, "disease": "", "pathway": " (rno:361545)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19170760", "class_list": "", "function": "Binds (via the RRM domain) to the 3' untranslated region (UTR) of p21 mRNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V8X1", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0048025 negative regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIE3-1", "uniprot_id": "RM11_RAT", "mass": 22420.0, "length": 203, "protein_name": "Large ribosomal subunit protein uL11m", "gene_name": "Mrpl11", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL11m", "refseq_ac": "NP_001006974", "gene_names_uniprotkb": "Mrpl11; mrpl11", "gene_names_refseq": "Mrpl11", "protein_names_uniprotkb": "Large ribosomal subunit protein uL11m; 39S ribosomal protein L11, mitochondrial; L11mt; MRP-L11", "protein_names_refseq": "39S ribosomal protein L11, mitochondrial; L11mt; MRP-L11; large ribosomal subunit protein uL11m", "tax_id": 10116, "disease": "", "pathway": " (rno:293666); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NYB7-1", "uniprot_id": "RAB1A_RAT", "mass": 22678.0, "length": 205, "protein_name": "Ras-related protein Rab-1A", "gene_name": "Rab1A; Rab1a", "organism": "Rat", "refseq_name": "ras-related protein Rab-1A", "refseq_ac": "NP_112352", "gene_names_uniprotkb": "Rab1A; Rab1a; Rab1", "gene_names_refseq": "Ac2-048; Rab1a; Rab1r; Rab1", "protein_names_uniprotkb": "Ras-related protein Rab-1A; 3.6.5.2", "protein_names_refseq": "RAB1, member RAS oncogene family; ras-related protein Rab-1A", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:81754); (R-RNO-162658); (R-RNO-204005); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "19423663;21303926;27502188;31491505;3317403;34502162", "class_list": "", "function": "Rab1A mediates proinsulin to insulin conversion in beta-cells by maintaining Golgi stability through interactions with golgin-84., [RefSeq, PubMed]; Restoration of Rab1 Levels Prevents Endoplasmic Reticulum Stress in Hippocampal Cells during Protein Aggregation Triggered by Rotenone., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21303926). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21303926). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926). Required to modulate the compacted morphology of the Golgi. Regulates the level of CASR present at the cell membrane (By similarity). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (By similarity). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05711", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;5.6.1.3;3.6.5.5;3.6.1.5;3.4.14.1;2.7.11.26;2.5.1.60;2.3.1.-;3.6.1.-;2.7.11.21;3.6.5.4;3.4.18.1", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:1903020 positive regulation of glycoprotein metabolic process;GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6NYB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4M9-1", "uniprot_id": "OSBL1_RAT", "mass": 107765.0, "length": 950, "protein_name": "Oxysterol-binding protein-related protein 1", "gene_name": "Osbpl1a", "organism": "Rat", "refseq_name": "oxysterol-binding protein-related protein 1", "refseq_ac": "NP_742020", "gene_names_uniprotkb": "Osbpl1a; Orp1", "gene_names_refseq": "Osbpl1a", "protein_names_uniprotkb": "Oxysterol-binding protein-related protein 1; ORP-1; OSBP-related protein 1", "protein_names_refseq": "ORP-1; OSBP-related protein 1; oxysterol-binding protein-related protein 1", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545)", "pathway": " (rno:259221); (R-RNO-192105); (R-RNO-2132295)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10965890;16004875", "class_list": "", "function": "Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0032935 sterol sensor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0042632 cholesterol homeostasis;GO:0090120 lysosome to ER cholesterol transport;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K4M9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V26-1", "uniprot_id": "SPHK1_RAT", "mass": 42418.0, "length": 383, "protein_name": "Sphingosine kinase 1", "gene_name": "Sphk1", "organism": "Rat", "refseq_name": "sphingosine kinase 1 isoform b", "refseq_ac": "NP_001257736", "gene_names_uniprotkb": "Sphk1", "gene_names_refseq": "Sphk1", "protein_names_uniprotkb": "Sphingosine kinase 1; 2.3.1.-; 2.7.1.91; Acetyltransferase SPHK1; SK 1; SPK 1", "protein_names_refseq": "SK 1; SPK 1; acetyltransferase SPHK1; sphingosine kinase 1 isoform b", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); adenocarcinoma (Disease Ontology:DOID:299); high grade glioma (Disease Ontology:DOID:3070); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:170897); (R-RNO-1660661); (R-RNO-390471); (R-RNO-5218921); (R-RNO-9009391); (R-RNO-9833482)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "11560121;16118219;26334640;28284343;31814336;33281190;33602274;35766986;38607078", "class_list": "", "function": "Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (Probable) (PubMed:16118219). In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis (By similarity). Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion (PubMed:28284343). In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway. Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity. In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury. Publication Status: Online-Only, [RefSeq, PubMed]; Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Role of Sphingosine Kinase 1 in Glucolipotoxicity-Induced Early Activation of Autophagy in INS-1 Pancreatic beta Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-delta in sepsis-associated liver injury. Publication Status: Online-Only, [RefSeq, PubMed]; Sphk1-induced autophagy in microglia promotes neuronal injury following cerebral ischaemia-reperfusion., [RefSeq, PubMed]; The Sphkl/SlP pathway regulates angiogenesis via NOS/NO synthesis following cerebral ischemia-reperfusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q642F6", "ec_number_list": "2.3.1.-;2.7.11.13;3.6.5.2;3.6.1.-;2.7.10.2;2.7.11.1;2.7.1.91", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030424 axon", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006670 sphingosine metabolic process;GO:0032740 positive regulation of interleukin-17 production;GO:1900060 negative regulation of ceramide biosynthetic process;GO:0032651 regulation of interleukin-1 beta production", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91V26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63665-1", "uniprot_id": "USF2_RAT", "mass": 36954.0, "length": 346, "protein_name": "Upstream stimulatory factor 2", "gene_name": "Usf2", "organism": "Rat", "refseq_name": "upstream stimulatory factor 2", "refseq_ac": "NP_112401", "gene_names_uniprotkb": "Usf2", "gene_names_refseq": "Usf2", "protein_names_uniprotkb": "Upstream stimulatory factor 2; Major late transcription factor 2; Upstream transcription factor 2", "protein_names_refseq": "major late transcription factor 2; transcription factor USF2; upstream stimulatory factor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:81817)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11272846;11319134;17955499;18167349;18955796;20410211;21734262;8576131", "class_list": "", "function": "Data suggest that glycated albumin upregulated USF2 gene transcription in mesangial cells through NF-kappaB-dependent transactivation of the USF2 promoter., [RefSeq, PubMed]; High glucose levels up-regulate USF2 gene transcription in mesangial cells through CREB-dependent transactivation of the USF2 promoter., [RefSeq, PubMed]; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; USF has a role in increasing TGF-beta1 protein levels, but not in indusing G1 phase arrest, [RefSeq, PubMed]; USF1 and USF2 are important contributors to neuronal-specific and mitogen-activated protein kinase regulation of the CGRP gene in trigeminal ganglion neurons, [RefSeq, PubMed]; Upstream stimulatory factors (USF1 and USF2) induce Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q76MJ1;Q76MU2;Q9EQX1;Q9EQX2;Q9EQX3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0055088 lipid homeostasis;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63665-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPZ8-1", "uniprot_id": "RN103_RAT", "mass": 79019.0, "length": 682, "protein_name": "E3 ubiquitin-protein ligase RNF103", "gene_name": "Rnf103", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rnf103; Zfp103", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF103; 2.3.2.27; Protein ADRG34; RING finger protein 103; RING-type E3 ubiquitin transferase RNF103; Zfp-103; Zinc finger protein 103", "protein_names_refseq": "", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:84508)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11071867;18675248", "class_list": "", "function": "Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EPZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKE3-1", "uniprot_id": "SCAM5_RAT", "mass": 26098.0, "length": 235, "protein_name": "Secretory carrier-associated membrane protein 5", "gene_name": "Scamp5", "organism": "Rat", "refseq_name": "secretory carrier-associated membrane protein 5 isoform 1", "refseq_ac": "NP_113914", "gene_names_uniprotkb": "Scamp5", "gene_names_refseq": "Scamp5", "protein_names_uniprotkb": "Secretory carrier-associated membrane protein 5; Secretory carrier membrane protein 5", "protein_names_refseq": "secretory carrier-associated membrane protein 5 isoform 1; secretory carrier-associated membrane protein 5", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:65171)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11050114;18171723;19240033;25057210;33663553", "class_list": "", "function": "Exposure to ER stress increases SCAMP5 in the striatum, which positively regulates mtHTT aggregation via the endocytosis pathway, [RefSeq, PubMed]; Knockdown of SCAMP5 severely impairs synaptic vesicle endocytosis during stimulation., [RefSeq, PubMed]; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity)., [UniProtKB]; SCAMP isoforms regulate membrane fusion and dense core vesicle exocytosis in neurons., [RefSeq, PubMed]; SCAMP5 mediates activity-dependent enhancement of NHE6 recruitment to synaptic vesicles during synaptic plasticity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032588 trans-Golgi network membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0015031 protein transport;GO:0001819 positive regulation of cytokine production;GO:0006887 exocytosis;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JKE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63623-1", "uniprot_id": "SCAF8_RAT", "mass": 139504.0, "length": 1268, "protein_name": "SR-related and CTD-associated factor 8", "gene_name": "Scaf8", "organism": "Rat", "refseq_name": "SR-related and CTD-associated factor 8 isoform 1", "refseq_ac": "NP_620794", "gene_names_uniprotkb": "Scaf8; Rbm16", "gene_names_refseq": "Rbm16; Scaf8", "protein_names_uniprotkb": "SR-related and CTD-associated factor 8; RNA-binding motif protein 16", "protein_names_refseq": "CTD-binding SR-like protein rA8; RNA-binding motif protein 16; SR-like CTD-associated factor 8; SR-related and CTD-associated factor 8 isoform 1; SR-related and CTD-associated factor 8; protein SCAF8; putative RNA-binding protein 16", "tax_id": 10116, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (rno:245926)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;8692929;9528809", "class_list": "", "function": "Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0000993 RNA polymerase II complex binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0005849 mRNA cleavage factor complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006366 transcription by RNA polymerase II;GO:0006369 termination of RNA polymerase II transcription;GO:0032786 positive regulation of DNA-templated transcription, elongation;GO:2000805 negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63623-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P689-1", "uniprot_id": "WLS_RAT", "mass": 62202.0, "length": 541, "protein_name": "Protein wntless homolog", "gene_name": "Wls", "organism": "Rat", "refseq_name": "protein wntless homolog", "refseq_ac": "NP_001078822", "gene_names_uniprotkb": "Wls; Gpr177", "gene_names_refseq": "Gpr177; Wls", "protein_names_uniprotkb": "Protein wntless homolog; EVI; Integral membrane protein GPR177; Protein evenness interrupted homolog", "protein_names_refseq": "EVI; G protein-coupled receptor 177; integral membrane protein GPR177; protein evenness interrupted homolog; protein wntless homolog; wntless Wnt ligand secretion mediator", "tax_id": 10116, "disease": "Zaki syndrome (Disease Ontology:DOID:0070473)", "pathway": " (rno:362065); (R-RNO-3238698)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15326124;20652957;26501177", "class_list": "", "function": "Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Also plays an important role in establishment of the anterior-posterior body axis formation during development (By similarity)., [UniProtKB]; Results link reduced expression of both the D2R and Wntless to the explicit motivation for heroin rather than to differences in total drug intake per se, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0017147 Wnt-protein binding;GO:0031852 mu-type opioid receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030902 hindbrain development;GO:0016055 Wnt signaling pathway;GO:0050775 positive regulation of dendrite morphogenesis;GO:0001707 mesoderm formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P689-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QX01-1", "uniprot_id": "TRPC1_RAT", "mass": 87618.0, "length": 759, "protein_name": "Short transient receptor potential channel 1", "gene_name": "Trpc1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Trpc1; Trp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Short transient receptor potential channel 1; TRP-1; Transient receptor protein 1; TrpC1", "protein_names_refseq": "", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); stomach cancer (Disease Ontology:DOID:10534); neurodegenerative disease (Disease Ontology:DOID:1289); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:89821); (R-RNO-3295583); (R-RNO-5578775); (R-RNO-983695)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10199829;11301024;27397542", "class_list": "", "function": "Forms a receptor-activated non-selective calcium permeant cation channel. Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.8.-.-", "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0051117 ATPase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0046541 saliva secretion;GO:0051592 response to calcium ion;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0060087 relaxation of vascular associated smooth muscle;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QX01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N02-1", "uniprot_id": "SO3A1_RAT", "mass": 76825.0, "length": 710, "protein_name": "Solute carrier organic anion transporter family member 3A1", "gene_name": "Slco3a1", "organism": "Rat", "refseq_name": "solute carrier organic anion transporter family member 3A1", "refseq_ac": "NP_803434", "gene_names_uniprotkb": "Slco3a1; Oatp3a1; Oatpd; Pgt2; Slc21a11", "gene_names_refseq": "Slc21a11; Slco3a1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 3A1; OATP-D; Organic anion-transporting polypeptide D; Prostaglandin transporter subtype 2; Sodium-independent organic anion transporter D; Solute carrier family 21 member 11", "protein_names_refseq": "OATP-D; organic anion-transporting polypeptide D; prostaglandin transporter subtype 2; sodium-independent organic anion transporter D; solute carrier family 21 (organic anion transporter), member 11; solute carrier family 21 member 11; solute carrier organic anion transporter family member 3A1", "tax_id": 10116, "disease": "", "pathway": " (rno:140915); (R-RNO-879518)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14631946;16971491", "class_list": "", "function": "Plays an important role in translocating prostaglandins in specialized tissues and cells., [RefSeq, PubMed]; Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner (By similarity) (PubMed:14631946). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). Mediates transport of tryptophan, phenyalanine, tyrosine, and steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;6.2.1.-;6.2.1.15", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0043410 positive regulation of MAPK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0015711 organic anion transport;GO:0015827 tryptophan transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99N02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXT0-1", "uniprot_id": "RM37_RAT", "mass": 48366.0, "length": 423, "protein_name": "Large ribosomal subunit protein mL37", "gene_name": "Mrpl37", "organism": "Rat", "refseq_name": "large ribosomal subunit protein mL37 isoform 1 precursor", "refseq_ac": "NP_001004235", "gene_names_uniprotkb": "Mrpl37", "gene_names_refseq": "L37mt; MRP-L37; Mrpl37; Rpml2", "protein_names_uniprotkb": "Large ribosomal subunit protein mL37; 39S ribosomal protein L37, mitochondrial; L37mt; MRP-L37", "protein_names_refseq": "39S ribosomal protein L37, mitochondrial; large ribosomal subunit protein mL37 isoform 1 precursor; large ribosomal subunit protein mL37; ribosomal protein, mitochondrial, L2", "tax_id": 10116, "disease": "", "pathway": " (rno:56281); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QX27-1", "uniprot_id": "ST18_RAT", "mass": 113434.0, "length": 1032, "protein_name": "Suppression of tumorigenicity 18 protein", "gene_name": "St18", "organism": "Rat", "refseq_name": "suppression of tumorigenicity 18 protein", "refseq_ac": "NP_695222", "gene_names_uniprotkb": "St18; Nzf3", "gene_names_refseq": "Nzf3; St18; r-MyT3", "protein_names_uniprotkb": "Suppression of tumorigenicity 18 protein; C2-HC type zinc finger protein r-MyT3; NZF-3; Neural zinc finger factor 3", "protein_names_refseq": "C2-HC type zinc finger protein r-MyT3; NZF-3; ST18, C2H2C-type zinc finger; neural zinc finger factor 3; suppression of tumorigenicity 18 protein; suppression of tumorigenicity protein 18", "tax_id": 10116, "disease": "", "pathway": " (rno:266680)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24509857;29393594;8980226;9478997", "class_list": "", "function": "Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters., [UniProtKB, PubMed]; ST18 expression and activity are increased in cytotoxic conditions in pancreatic beta-cells. Overexpression of ST18 causes apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P70588", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QX27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68H95-1", "uniprot_id": "REPI1_RAT", "mass": 61951.0, "length": 548, "protein_name": "DNA-binding protein REPIN1", "gene_name": "Repin1", "organism": "Rat", "refseq_name": "DNA-binding protein REPIN1 isoform 5", "refseq_ac": "NP_001005893", "gene_names_uniprotkb": "Repin1", "gene_names_refseq": "Ap-4; Ap4; Repin1", "protein_names_uniprotkb": "DNA-binding protein REPIN1", "protein_names_refseq": "DNA-binding protein REPIN1 isoform 5; DNA-binding protein REPIN1", "tax_id": 10116, "disease": "", "pathway": " (rno:445541)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14572453;17173329;21701954", "class_list": "", "function": "Data on gene expression in epididymal/subcutaneous adipose tissue suggest that Repin1 is more highly expressed in a congenic rat model of metabolic syndrome; thus, Repin1 may affect development of facets of metabolic syndrome., [RefSeq, PubMed]; Findings show that glutamate receptor delta2 interacted directly with AP-4; results suggest a potential involvement of AP-4 in the trafficking of delta2 in the brain., [RefSeq, PubMed]; Sequence-specific double-stranded DNA-binding protein. Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (By similarity). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The functional unknown gene, Repin1, may be a novel candidate gene for the development of facets of the metabolic syndrome. GeneRIF: It is concluded that the triplet repeat expansion in 3'-UTR of Repin1 leads to metabolic disorders as found in hHTG and WOKW rats and that Repin1 could be a novel candidate gene in the development of metabolic disorders., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0046326 positive regulation of D-glucose import;GO:2000191 regulation of fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q68H95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3Y7-1", "uniprot_id": "TNF15_RAT", "mass": 28029.0, "length": 252, "protein_name": "Tumor necrosis factor ligand superfamily member 15", "gene_name": "Tnfsf15", "organism": "Rat", "refseq_name": "tumor necrosis factor ligand superfamily member 15", "refseq_ac": "NP_665708", "gene_names_uniprotkb": "Tnfsf15; Tl1; Vegi", "gene_names_refseq": "Tnfsf15; Tnlg1b", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor", "protein_names_refseq": "TNF ligand-related molecule 1; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand 1b; tumor necrosis factor ligand superfamily member 15; tumor necrosis factor superfamily member 15; vascular endothelial cell growth inhibitor", "tax_id": 10116, "disease": "inflammatory bowel disease 16 (Disease Ontology:DOID:0110896)", "pathway": " (rno:252878); (R-RNO-5669034)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11911831;20572782;26125742", "class_list": "", "function": "Cytokine that signals through TNFRSF25 receptor. Functions as a T-cell costimulator, that increases IL-2 responsiveness and secretion of proinflammatory cytokines which enhances T-cell activation, proliferation and the survival of activated T-cells. Inhibits vascular endothelial growth and angiogenesis (in vitro)., [UniProtKB, UniProtKB]; Examined the mammary gland during pregnancy, lactation, and involution periods; identified the localization and distribution of VEGI (TNFSF15), [RefSeq, PubMed]; Expression in control and blank groups was similar at 3 and 6 months. Atorvastatin can inhibit VEGI and vascular endothelial growth factor expression to protect rats from diabetic retinopathy Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Promotes splenocyte alloactivation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0007250 activation of NF-kappaB-inducing kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K3Y7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXR8-1", "uniprot_id": "ORAI3_RAT", "mass": 31311.0, "length": 290, "protein_name": "Protein orai-3", "gene_name": "Orai3", "organism": "Rat", "refseq_name": "protein orai-3", "refseq_ac": "NP_001014046", "gene_names_uniprotkb": "Orai3; Tmem142c", "gene_names_refseq": "CRACM3; Orai3; RGD1306538", "protein_names_uniprotkb": "Protein orai-3; Transmembrane protein 142C", "protein_names_refseq": "calcium release-activated calcium modulator 3 protein; protein orai-3; transmembrane protein 142C", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:309000)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "23349245;23878392;25213556;27301714;30988334;33784009;37047790;37686206", "class_list": "", "function": "CRACM3 affects cell exocytosis by influencing the activity-dependent fusion pore open time. Extracellular loop 3 and the C-terminus of CRACM3 are critical for binding the N-peptide of syntaxin-4. Publication Status: Online-Only, [RefSeq, PubMed]; Cardiac Orai3 is the essential partner of STIM1 and drives voltage-independent Ca(2+) entry in adult cardiomyocytes. Arachidonic acid-activated currents supported by Orai3 are present in adult cardiomyocytes and increased during hypertrophy., [RefSeq, PubMed]; Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR2- and Orai3- dependent signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Orai channels are activated by different agonists/pathways and uncover a mechanism whereby leukotrieneC4 acts through hitherto unknown intracrine mode to elicit store-independent Ca(2+) signaling that promotes vascular occlusive disease., [RefSeq, PubMed]; Orai3 exacerbates apoptosis of lens epithelial cells by disrupting Ca(2+) homeostasis in diabetic cataract., [RefSeq, PubMed]; Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels. Assembles with ORAI1 and ORAI2 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription. Assembles with ORAI1 to form channels that mediate store-independent Ca(2+) influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively., [UniProtKB, UniProtKB]; Role of Orai3-Mediated Store-Operated Calcium Entry in Radiation-Induced Brain Microvascular Endothelial Cell Injury. Publication Status: Online-Only, [RefSeq, PubMed]; The second coiled-coil domain of STIM1 is required for coupling to either Orai3 or Orai3/Orai1 channels., [RefSeq, PubMed]; Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0015279 store-operated calcium channel activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6AXR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FV4-1", "uniprot_id": "SPEM2_RAT", "mass": 56915.0, "length": 504, "protein_name": "Uncharacterized protein SPEM2", "gene_name": "Spem2", "organism": "Rat", "refseq_name": "uncharacterized protein SPEM2", "refseq_ac": "NP_001017475", "gene_names_uniprotkb": "Spem2; LOC497938", "gene_names_refseq": "Spem2", "protein_names_uniprotkb": "Uncharacterized protein SPEM2", "protein_names_refseq": "uncharacterized protein C17orf74 homolog; uncharacterized protein SPEM2", "tax_id": 10116, "disease": "", "pathway": " (rno:497938)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2J5-1", "uniprot_id": "VAMP5_RAT", "mass": 11495.0, "length": 102, "protein_name": "Vesicle-associated membrane protein 5", "gene_name": "Vamp5", "organism": "Rat", "refseq_name": "vesicle-associated membrane protein 5", "refseq_ac": "NP_446007", "gene_names_uniprotkb": "Vamp5", "gene_names_refseq": "Vamp5", "protein_names_uniprotkb": "Vesicle-associated membrane protein 5; Myobrevin; VAMP-5", "protein_names_refseq": "VAMP-5; myobrevin; vesicle-associated membrane protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:89818)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19675279;9725904", "class_list": "", "function": "May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking., [UniProtKB]; VAMP2, VAMP5, and VAMP7 may be involved in translocation of GLUT4 during muscle contractions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0014704 intercalated disc;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0043001 Golgi to plasma membrane protein transport;GO:0007519 skeletal muscle tissue development;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z2J5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TT47-1", "uniprot_id": "SPG7_RAT", "mass": 86103.0, "length": 781, "protein_name": "Mitochondrial inner membrane m-AAA protease component paraplegin", "gene_name": "Spg7", "organism": "Rat", "refseq_name": "mitochondrial inner membrane m-AAA protease component paraplegin isoform 1", "refseq_ac": "NP_852053", "gene_names_uniprotkb": "Spg7", "gene_names_refseq": "Spg7", "protein_names_uniprotkb": "Mitochondrial inner membrane m-AAA protease component paraplegin; 3.4.24.-; 3.6.-.-; Paraplegin", "protein_names_refseq": "SPG7, paraplegin matrix AAA peptidase subunit; mitochondrial inner membrane m-AAA protease component paraplegin isoform 1; mitochondrial inner membrane m-AAA protease component paraplegin; paraplegin; spastic paraplegia 7 homolog", "tax_id": 10116, "disease": "hereditary spastic paraplegia 7 (Disease Ontology:DOID:0110816)", "pathway": " (rno:353231); (R-RNO-8949664); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "26387735", "class_list": "", "function": "Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins, and which is essential for axonal and neuron development (By similarity). SPG7 possesses both ATPase and protease activities: the ATPase activity is required to unfold substrates, threading them into the internal proteolytic cavity for hydrolysis into small peptide fragments (By similarity). The m-AAA protease exerts a dual role in the mitochondrial inner membrane: it mediates the processing of specific regulatory proteins and ensures protein quality control by degrading misfolded polypeptides (By similarity). Mediates protein maturation of the mitochondrial ribosomal subunit MRPL32/bL32m by catalyzing the cleavage of the presequence of MRPL32/bL32m prior to assembly into the mitochondrial ribosome (By similarity). Acts as a regulator of calcium in neurons by mediating degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (By similarity). Also regulates mitochondrial calcium by catalyzing degradation of MCU (By similarity). Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K536", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;3.4.24.64;2.7.4.3;3.1.4.-;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:1904115 axon cytoplasm;GO:0005745 m-AAA complex;GO:0005757 mitochondrial permeability transition pore complex", "go_biological_process": "GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death;GO:0046902 regulation of mitochondrial membrane permeability;GO:0008089 anterograde axonal transport;GO:0007005 mitochondrion organization;GO:0034982 mitochondrial protein processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TT47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2V2-1", "uniprot_id": "CD40L_RAT", "mass": 29260.0, "length": 260, "protein_name": "CD40 ligand", "gene_name": "Cd40lg", "organism": "Rat", "refseq_name": "CD40 ligand", "refseq_ac": "NP_445805", "gene_names_uniprotkb": "Cd40lg; Cd40l; Tnfsf5", "gene_names_refseq": "Cd40lg; Cd40l; Tnfsf5", "protein_names_uniprotkb": "CD40 ligand; CD40-L; Tumor necrosis factor ligand superfamily member 5", "protein_names_refseq": "CD40 ligand CD154; CD40 ligand; CD40-L; tumor necrosis factor ligand superfamily member 5", "tax_id": 10116, "disease": "cutaneous lupus erythematosus (Disease Ontology:DOID:0050169); tick-borne encephalitis (Disease Ontology:DOID:0050175); erythema multiforme (Disease Ontology:DOID:0050185); inflammatory bowel disease (Disease Ontology:DOID:0050589); vitamin B12 deficiency (Disease Ontology:DOID:0050731); follicular lymphoma (Disease Ontology:DOID:0050873); CD40 ligand deficiency (Disease Ontology:DOID:0060022); thrombosis (Disease Ontology:DOID:0060903); overactive bladder syndrome (Disease Ontology:DOID:0070355); lupus nephritis (Disease Ontology:DOID:0080162); dermatomyositis (Disease Ontology:DOID:10223); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); sickle cell anemia (Disease Ontology:DOID:10923); familial hyperlipidemia (Disease Ontology:DOID:1168); dysgammaglobulinemia (Disease Ontology:DOID:11702); diabetic angiopathy (Disease Ontology:DOID:11713); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); Graves' disease (Disease Ontology:DOID:12361); aplastic anemia (Disease Ontology:DOID:12449); cardiovascular system disease (Disease Ontology:DOID:1287); Sjogren's syndrome (Disease Ontology:DOID:12894); HELLP syndrome (Disease Ontology:DOID:13133); Behcet's disease (Disease Ontology:DOID:13241); Kawasaki disease (Disease Ontology:DOID:13378); eosinophilic esophagitis (Disease Ontology:DOID:13922); cystic fibrosis (Disease Ontology:DOID:1485); atherosclerosis (Disease Ontology:DOID:1936); essential thrombocythemia (Disease Ontology:DOID:2224); pulmonary tuberculosis (Disease Ontology:DOID:2957); antiphospholipid syndrome (Disease Ontology:DOID:2988); periodontal disease (Disease Ontology:DOID:3388); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); allergic rhinitis (Disease Ontology:DOID:4481); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); Ehrlich tumor carcinoma (Disease Ontology:DOID:5050); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); combined T cell and B cell immunodeficiency (Disease Ontology:DOID:628); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); cocaine abuse (Disease Ontology:DOID:809); periodontitis (Disease Ontology:DOID:824); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); narcolepsy (Disease Ontology:DOID:8986); systemic lupus erythematosus (Disease Ontology:DOID:9074); pemphigus (Disease Ontology:DOID:9182); lichen planus (Disease Ontology:DOID:9201); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:84349); (R-RNO-198933); (R-RNO-5668541); (R-RNO-5676594)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10826698;29843579;36592325", "class_list": "", "function": "Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Arterial Baroreflex Dysfunction Promotes Neuroinflammation by Activating the Platelet CD40L/Nuclear Factor Kappa B Signaling Pathway in Microglia and Astrocytes., [RefSeq, PubMed]; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching., [UniProtKB, UniProtKB]; Transient middle cerebral artery occlusion (MCAO) rats yielded an acceleration of thrombus formation that was accompanied by increased CD40 levels in serum. The brain infarction was significantly decreased in CD40 antagonist treatment group compared to MCAO model group. The mTOR/S6K signaling was activated in MACO model than that of CD40 antagonist treatment group. Erratum:[Neurol Res. 2019 Jan;41(1):98. doi: 10.1080/01616412.2018.1526508. PMID: 30311854], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 58, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R254", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005125 cytokine activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0005174 CD40 receptor binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0044297 cell body", "go_biological_process": "GO:2001200 positive regulation of dendritic cell differentiation;GO:0002637 regulation of immunoglobulin production;GO:0023035 CD40 signaling pathway;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z2V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924P2-1", "uniprot_id": "TM14C_RAT", "mass": 11776.0, "length": 115, "protein_name": "Transmembrane protein 14C", "gene_name": "Tmem14c", "organism": "Rat", "refseq_name": "transmembrane protein 14C", "refseq_ac": "NP_599222", "gene_names_uniprotkb": "Tmem14c; Cdtw1; Pak1ip1", "gene_names_refseq": "Cdtw1; Tmem14c", "protein_names_uniprotkb": "Transmembrane protein 14C; p11", "protein_names_refseq": "P11 protein; transmembrane protein 14C", "tax_id": 10116, "disease": "", "pathway": " (rno:171432)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly., [UniProtKB, UniProtKB]; Required for normal heme biosynthesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0005730 nucleolus;GO:0016020 membrane", "go_biological_process": "GO:0006839 mitochondrial transport;GO:0030218 erythrocyte differentiation;GO:0006783 heme biosynthetic process;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q924P2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78EH2-1", "uniprot_id": "PCSK4_RAT", "mass": 75740.0, "length": 678, "protein_name": "Proprotein convertase subtilisin/kexin type 4", "gene_name": "Pcsk4", "organism": "Rat", "refseq_name": "proprotein convertase subtilisin/kexin type 4 precursor", "refseq_ac": "NP_598243", "gene_names_uniprotkb": "Pcsk4; Nec-3; Nec3", "gene_names_refseq": "Pcsk4", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 4; 3.4.21.-; KEX2-like endoprotease 3; NEC 3; Neuroendocrine convertase 3; PC4; Prohormone convertase 3", "protein_names_refseq": "KEX2-like endoprotease 3; NEC 3; PC4; neuroendocrine convertase 3; prohormone convertase 3; proprotein convertase subtilisin/kexin type 4 precursor", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:171085)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1448111;21080038", "class_list": "", "function": "Maturation by propeptide removal occurs very inefficiently when rat or human proPCSK4 is overexpressed in HEK293 cells., [RefSeq, PubMed]; Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (By similarity). May also participate in folliculogenesis in the ovaries (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1A4C9;Q07213;Q07214", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0009566 fertilization;GO:0016485 protein processing;GO:0016486 peptide hormone processing;GO:0007340 acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q78EH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q811A3-1", "uniprot_id": "PLOD2_RAT", "mass": 84542.0, "length": 737, "protein_name": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "gene_name": "Plod2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Plod2", "gene_names_refseq": "", "protein_names_uniprotkb": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; 1.14.11.4; LH2; Lysyl hydroxylase 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Bruck syndrome (Disease Ontology:DOID:0060231); Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); migraine without aura (Disease Ontology:DOID:12783); toxic shock syndrome (Disease Ontology:DOID:14115); hypothyroidism (Disease Ontology:DOID:1459); neuroendocrine carcinoma (Disease Ontology:DOID:1800); breast carcinoma (Disease Ontology:DOID:3459); lung adenocarcinoma (Disease Ontology:DOID:3910); brain disease (Disease Ontology:DOID:936)", "pathway": " (rno:300901); (R-RNO-1650814)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q811A4", "ec_number_list": "2.4.1.50;1.14.11.4;2.4.1.66", "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0008475 procollagen-lysine 5-dioxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001666 response to hypoxia;GO:0030199 collagen fibril organization;GO:0032870 cellular response to hormone stimulus;GO:0032964 collagen biosynthetic process;GO:0046947 hydroxylysine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q811A3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63644-1", "uniprot_id": "ROCK1_RAT", "mass": 159626.0, "length": 1369, "protein_name": "Rho-associated protein kinase 1", "gene_name": "Rock1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rock1; Ac2-154", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho-associated protein kinase 1; 2.7.11.39; Liver regeneration-related protein LRRG199; ROCK-I; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; p150 RhoA-binding kinase ROK beta; p160 ROCK-1; p160ROCK", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-111465); (R-RNO-3928662); (R-RNO-416482); (R-RNO-416572); (R-RNO-4420097); (R-RNO-5627117); (R-RNO-6798695); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013407); (R-RNO-9013422); (R-RNO-9696264)", "pathway_count": 13, "publication_count": 4, "publication_id_list": "19131646;29393594;8816443;9353125", "class_list": "", "function": "Protein kinase which is a key regulator of actin cytoskeleton and cell polarity., [UniProtKB, UniProtKB]; Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:19131646, PubMed:9353125). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:19131646, PubMed:9353125). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By similarity). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TP31", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.10.2;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;5.2.1.8;2.7.1.40;2.7.11.12;2.7.11.26;2.3.1.-;2.7.11.34;2.7.10.1;1.1.1.205;2.3.2.27;2.7.1.150;2.7.11.13;3.5.4.5;3.6.4.13;2.4.1.25;3.2.1.33;4.2.99.18;5.6.2.4;4.1.1.32;4.1.2.4;3.1.3.48;2.4.1.186;3.5.4.6;3.1.1.47;2.7.1.35;3.1.4.-;3.1.4.35;1.11.1.6;2.5.1.18;4.1.2.13;3.6.5.-;4.2.1.24;2.7.3.2;3.6.5.2;2.4.1.1;1.13.11.-;1.13.11.34;2.7.11.19;2.7.2.3;3.1.2.-;7.6.2.-;2.7.13.3;1.14.14.18;5.4.2.11;5.4.2.4;2.7.11.11;2.7.1.1;2.7.1.11;5.3.2.1;5.3.3.12;3.4.21.46;2.7.10.4;3.1.6.4;2.4.2.7;1.1.1.42;3.6.4.6;2.3.2.26;2.7.11.31;3.4.22.56;3.6.4.10;3.1.3.16;3.6.4.-;3.1.4.4;2.4.2.1;2.7.11.4;2.3.1.48;3.1.11.-;2.7.4.18;3.1.24.-;3.4.19.12;3.6.1.-;2.7.11.39;5.3.1.9;5.1.3.-;2.4.99.18;3.4.25.1;3.4.17.22;2.7.11.10;1.11.1.24;2.1.1.13", "go_molecular_function": "GO:0072518 Rho-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:1905205 positive regulation of connective tissue replacement;GO:0022614 membrane to membrane docking;GO:1903140 regulation of establishment of endothelial barrier;GO:1903347 negative regulation of bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63644-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66X93-1", "uniprot_id": "SND1_RAT", "mass": 101952.0, "length": 909, "protein_name": "Staphylococcal nuclease domain-containing protein 1", "gene_name": "Snd1", "organism": "Rat", "refseq_name": "staphylococcal nuclease domain-containing protein 1", "refseq_ac": "NP_073185", "gene_names_uniprotkb": "Snd1", "gene_names_refseq": "SND p102; Snd1", "protein_names_uniprotkb": "Staphylococcal nuclease domain-containing protein 1; 100 kDa coactivator; 3.1.31.1; SND p102; p100 co-activator; p105 coactivator", "protein_names_refseq": "100 kDa coactivator; p100 co-activator; p105 coactivator; staphylococcal nuclease domain containing 1; staphylococcal nuclease domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:64635)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16798076;17341622;22673903;24882364;29393594;35320827;36803376;37749650", "class_list": "", "function": "Absence of TATA box and location and reverse orientation of the CCAAT boxes in the promoter region strongly suggest a role for NF-Y in the regulation of transcription of SND p102 gene., [RefSeq, PubMed]; Cells overexpressing SND p102 secreted phospholipid-rich lipoproteins, [RefSeq, PubMed]; Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1. Publication Status: Online-Only, [RefSeq, PubMed]; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity). Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity). Plays a role in PIM1 regulation of MYB activity (By similarity). Functions as a transcriptional coactivator for STAT5 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1beta-stimulated chondrocytes via PINK1/BECN1 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97693;Q6IN40", "ec_number_list": "", "go_molecular_function": "GO:1905172 RISC complex binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0004519 endonuclease activity;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0042470 melanosome;GO:0097433 dense body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006402 mRNA catabolic process;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0010564 regulation of cell cycle process;GO:0010587 miRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q66X93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N37-1", "uniprot_id": "RHG17_RAT", "mass": 93754.0, "length": 858, "protein_name": "Rho GTPase-activating protein 17", "gene_name": "Arhgap17", "organism": "Rat", "refseq_name": "rho GTPase-activating protein 17 isoform 1", "refseq_ac": "NP_001257621", "gene_names_uniprotkb": "Arhgap17", "gene_names_refseq": "Arhgap17; Rich1", "protein_names_uniprotkb": "Rho GTPase-activating protein 17; Nadrin; Neuron-associated developmentally-regulated protein; Rho-type GTPase-activating protein 17", "protein_names_refseq": "neuron-associated developmentally-regulated protein; neuron-specific GTPase-activating protein; rho GTPase-activating protein 17 isoform 1; rho GTPase-activating protein 17; rho-type GTPase-activating protein 17", "tax_id": 10116, "disease": "acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:63994); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013423)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10967100;12358749;22673903", "class_list": "", "function": "Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere (By similarity). Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8R506;Q99N38;Q9EQV7", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0017156 calcium-ion regulated exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99N37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1F2-1", "uniprot_id": "SC5AB_RAT", "mass": 73605.0, "length": 673, "protein_name": "Sodium/myo-inositol cotransporter 2", "gene_name": "Slc5a11", "organism": "Rat", "refseq_name": "sodium/myo-inositol cotransporter 2", "refseq_ac": "NP_001093952", "gene_names_uniprotkb": "Slc5a11; Kst1; Smit2", "gene_names_refseq": "Kst1; SMIT2; Slc5a11", "protein_names_uniprotkb": "Sodium/myo-inositol cotransporter 2; Na(+)/myo-inositol cotransporter 2; SMIT2; Sodium-dependent glucose cotransporter; Sodium/glucose cotransporter KST1; Sodium/myo-inositol transporter 2; Solute carrier family 5 member 11; rkST1", "protein_names_refseq": "Na(+)/myo-inositol cotransporter 2; na+/myo-inositol cotransporter 2; sodium-cotransporter rkST1; sodium-dependent glucose cotransporter; sodium/glucose cotransporter KST1; sodium/myo-inositol cotransporter 2; sodium/myo-inositol transporter 2; solute carrier family 5 (sodium/glucose cotransporter), member 11; solute carrier family 5 (sodium/inositol cotransporter), member 11", "tax_id": 10116, "disease": "", "pathway": " (rno:252854); (R-RNO-429593)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17932225", "class_list": "", "function": "Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Can also transport D-chiro-inositol (DCI) but not L-fucose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0005365 myo-inositol transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0006814 sodium ion transport;GO:0015798 myo-inositol transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z1F2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLM2-1", "uniprot_id": "CD244_RAT", "mass": 35300.0, "length": 311, "protein_name": "Natural killer cell receptor 2B4", "gene_name": "Cd244l1; Cd244", "organism": "Rat", "refseq_name": "natural killer cell receptor 2B4 precursor", "refseq_ac": "NP_071595", "gene_names_uniprotkb": "Cd244l1; Cd244; 2b4; Nmrk", "gene_names_refseq": "2B4; Cd244l1; Cd244; Nmrk", "protein_names_uniprotkb": "Natural killer cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; Non-MHC restricted killing associated", "protein_names_refseq": "CD244 natural killer cell receptor 2B4; Cd244 molecule, natural killer cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; natural killer cell receptor 2B4 precursor; natural killer cell receptor 2B4; non-MHC restricted killing associated; transmembrane NK cell receptor 2B4", "tax_id": 10116, "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:64025); (R-RNO-202733)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10803843;16803907;29393594", "class_list": "", "function": "CD48 is a CD2 and CD244 (2B4)-binding protein, [RefSeq, PubMed]; Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor. Activating function implicates association with SH2D1A and FYN. Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2. Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (By similarity). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1. At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (By similarity). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLM3", "ec_number_list": "", "go_molecular_function": "GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0002323 natural killer cell activation involved in immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JLM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6R556-1", "uniprot_id": "SEGN_RAT", "mass": 32157.0, "length": 276, "protein_name": "Secretagogin", "gene_name": "Scgn", "organism": "Rat", "refseq_name": "secretagogin", "refseq_ac": "NP_963855", "gene_names_uniprotkb": "Scgn", "gene_names_refseq": "Scgn", "protein_names_uniprotkb": "Secretagogin", "protein_names_refseq": "secretagogin", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:306942)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11709487;17426113;20061514;23102406;28193530;28223495;31512254", "class_list": "", "function": "Characterization of the human secretagogin homolog., [RefSeq, PubMed]; Differential expression of secretagogin immunostaining in the hippocampal formation and the entorhinal and perirhinal cortices of humans, rats, and mice., [RefSeq, PubMed]; Scgn is a CaBP expressed in a subpopulation of nociceptive DRG neurons and their processes in the dorsal horn. Publication Status: Online-Only, [RefSeq, PubMed]; Secretagogin, characterizes novel groups of interneurons in the rat striatum, [RefSeq, PubMed]; Secretagogin-dependent MMP2 release from neurons regulates neuroblast migration., [RefSeq, PubMed]; The sequence homology and the comparable tissue expression patterns of human and rat secretagogin indicate conserved intracellular functions., [RefSeq, PubMed]; There is an association of TAU and the calcium-binding protein SCGN in insulin-secreting cells implicating beta-cells as an extra cerebral site of tauopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043195 terminal bouton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6R556-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHW1-1", "uniprot_id": "CBPD_RAT", "mass": 152616.0, "length": 1378, "protein_name": "Carboxypeptidase D", "gene_name": "Cpd", "organism": "Rat", "refseq_name": "carboxypeptidase D precursor", "refseq_ac": "NP_036968", "gene_names_uniprotkb": "Cpd", "gene_names_refseq": "Cpd", "protein_names_uniprotkb": "Carboxypeptidase D; 3.4.17.22; Metallocarboxypeptidase D; gp180", "protein_names_refseq": "carboxypeptidase D precursor; gp180; metallocarboxypeptidase D", "tax_id": 10116, "disease": "", "pathway": " (rno:25306); (R-RNO-432722); (R-RNO-9696264); (R-RNO-9696273)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11181555;15918796;21454685;22673903;24090084;38843836;9260933", "class_list": "", "function": "Functions in the processing of proteins and peptides in the secretory pathway. Mechanistically, cleaves exclusively C-terminal basic residues. By removing terminal residues, can modulate the activity, stability, and receptor-binding properties of bioactive peptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The isolation and characterization of CPD from several haematopoietic tumour cells are reported., [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "O35850", "ec_number_list": "3.6.5.2;2.7.10.1;3.1.3.86;3.1.3.56;3.1.3.36;2.7.1.153;2.7.1.137;2.7.1.154;3.1.3.48;2.7.3.2;1.2.1.3;1.2.1.94;3.6.5.5;3.6.4.10;2.7.11.1;2.7.11.39;3.6.4.13;3.4.17.22", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0004181 metallocarboxypeptidase activity;GO:0051721 protein phosphatase 2A binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0006518 peptide metabolic process;GO:0071352 cellular response to interleukin-2", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JHW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99NH3-1", "uniprot_id": "R3GEF_RAT", "mass": 41908.0, "length": 377, "protein_name": "Guanine nucleotide exchange factor for Rab-3A", "gene_name": "Rab3il1", "organism": "Rat", "refseq_name": "guanine nucleotide exchange factor for Rab-3A", "refseq_ac": "NP_599238", "gene_names_uniprotkb": "Rab3il1; Grab", "gene_names_refseq": "Grab; Rab3il1", "protein_names_uniprotkb": "Guanine nucleotide exchange factor for Rab-3A; Rab-3A-interacting-like protein 1; Rab3A-interacting-like protein 1; Rabin3-like 1", "protein_names_refseq": "RAB3A interacting protein (rabin3)-like 1; guanine nucleotide exchange factor for Rab-3A; guanine nucleotide exchange factor for Rab3A; rab-3A-interacting-like protein 1; rab3A-interacting-like protein 1; rabin3-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:171452); (R-RNO-8876198)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11516400;22673903", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0019900 kinase binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99NH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQP6-1", "uniprot_id": "TNI3K_RAT", "mass": 92732.0, "length": 835, "protein_name": "Serine/threonine-protein kinase TNNI3K", "gene_name": "Tnni3k", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase TNNI3K", "refseq_ac": "NP_861434", "gene_names_uniprotkb": "Tnni3k; Cark", "gene_names_refseq": "Cark; Tnni3k", "protein_names_uniprotkb": "Serine/threonine-protein kinase TNNI3K; 2.7.11.1; Cardiac ankyrin repeat kinase; TNNI3-interacting kinase", "protein_names_refseq": "cardiac ankyrin repeat kinase; serine/threonine-protein kinase TNNI3K", "tax_id": 10116, "disease": "", "pathway": " (rno:295531)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23369981;23472207", "class_list": "", "function": "May play a role in cardiac physiology., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TNNI3K may be a novel mediator of cardiac troponin I phosphorylation and contribute to the regulation of cardiac myofilament contraction function., [RefSeq, PubMed]; TNNI3K promotes a concentric hypertrophy with enhancement of cardiac function via regulating the phosphorylation of cTnI, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0086069 bundle of His cell to Purkinje myocyte communication;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:1903779 regulation of cardiac conduction;GO:0055117 regulation of cardiac muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TQP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6K0P5-1", "uniprot_id": "TM171_RAT", "mass": 34730.0, "length": 323, "protein_name": "Transmembrane protein 171", "gene_name": "Tmem171", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tmem171; Prp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein 171; Parturition-related protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:293634)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6K0P5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXS8-1", "uniprot_id": "TPGS2_RAT", "mass": 33163.0, "length": 296, "protein_name": "Tubulin polyglutamylase complex subunit 2", "gene_name": "Tpgs2", "organism": "Rat", "refseq_name": "tubulin polyglutamylase complex subunit 2", "refseq_ac": "NP_001014169", "gene_names_uniprotkb": "Tpgs2", "gene_names_refseq": "Pgs2; RGD1310571; Tpgs2", "protein_names_uniprotkb": "Tubulin polyglutamylase complex subunit 2; PGs2", "protein_names_refseq": "tubulin polyglutamylase complex subunit 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361301)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005874 microtubule;GO:0034451 centriolar satellite", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H44-1", "uniprot_id": "TM39B_RAT", "mass": 56375.0, "length": 492, "protein_name": "Transmembrane protein 39B", "gene_name": "Tmem39b", "organism": "Rat", "refseq_name": "transmembrane protein 39B", "refseq_ac": "NP_001014214", "gene_names_uniprotkb": "Tmem39b", "gene_names_refseq": "Tmem39b", "protein_names_uniprotkb": "Transmembrane protein 39B", "protein_names_refseq": "transmembrane protein 39B", "tax_id": 10116, "disease": "", "pathway": " (rno:362608)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H44-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63507-1", "uniprot_id": "RL14_RAT", "mass": 23339.0, "length": 214, "protein_name": "Large ribosomal subunit protein eL14", "gene_name": "Rpl14", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rpl14", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein eL14; 60S ribosomal protein L14", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "8670222", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63507-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VD88-1", "uniprot_id": "RNS1D_RAT", "mass": 16936.0, "length": 150, "protein_name": "Ribonuclease pancreatic delta-type", "gene_name": "Rnase1d; Rnase1l1", "organism": "Rat", "refseq_name": "ribonuclease pancreatic delta-type precursor", "refseq_ac": "NP_001013250", "gene_names_uniprotkb": "Rnase1d; Rnase1l1; Rnase1", "gene_names_refseq": "RNase 1; Rac1; Rnase1d; Rnase1l1", "protein_names_uniprotkb": "Ribonuclease pancreatic delta-type; 4.6.1.18; RNase 1 delta", "protein_names_refseq": "RNase 1 delta; pancreatic ribonuclease delta; ribonuclease A c1; ribonuclease pancreatic delta-type precursor; ribonuclease pancreatic delta-type; ribonuclease, RNase A family, 1-like 1 (pancreatic)", "tax_id": 10116, "disease": "", "pathway": " (rno:364303)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12399926", "class_list": "", "function": "Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004540 RNA nuclease activity;GO:0004522 ribonuclease A activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VD88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76IQ7-1", "uniprot_id": "TOX2_RAT", "mass": 49876.0, "length": 473, "protein_name": "TOX high mobility group box family member 2", "gene_name": "Tox2", "organism": "Rat", "refseq_name": "TOX high mobility group box family member 2", "refseq_ac": "NP_955424", "gene_names_uniprotkb": "Tox2; Gcx-1; Gcx1", "gene_names_refseq": "GCX-1; Gcx1; Tox2", "protein_names_uniprotkb": "TOX high mobility group box family member 2; GCX-1; Granulosa cell HMG box protein 1", "protein_names_refseq": "TOX high mobility group box family member 2; granulosa cell HMG box protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:311615)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14764631", "class_list": "", "function": "Data strongly suggest that granulosa cell HMG-box protein-1(GCX-1) is a novel transcriptional activator that is expressed in reproductive tissues involving the hypothalamo-pituitary-gonadal axis, and functions as a regulator of follicular development, [RefSeq, PubMed]; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0031490 chromatin DNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008585 female gonad development;GO:0034698 response to gonadotropin", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q76IQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6JHU9-1", "uniprot_id": "CBP_RAT", "mass": 265424.0, "length": 2442, "protein_name": "Histone lysine acetyltransferase CREBBP", "gene_name": "Crebbp", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Crebbp; Cbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone lysine acetyltransferase CREBBP; 2.3.1.-; 2.3.1.48; Protein lactyltransferas CREBBP; Protein-lysine acetyltransferase CREBBP", "protein_names_refseq": "", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); autism spectrum disorder (Disease Ontology:DOID:0060041); pre-eclampsia (Disease Ontology:DOID:10591); Huntington's disease (Disease Ontology:DOID:12858); alcohol use disorder (Disease Ontology:DOID:1574); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:54244); (R-RNO-1234158); (R-RNO-201722); (R-RNO-3134973); (R-RNO-3371568); (R-RNO-350054); (R-RNO-400206); (R-RNO-5621575); (R-RNO-8866907); (R-RNO-8939246); (R-RNO-8941856); (R-RNO-9018519); (R-RNO-933541); (R-RNO-9617629); (R-RNO-9707564); (R-RNO-9759194); (R-RNO-9841922); (R-RNO-9856649)", "pathway_count": 18, "publication_count": 2, "publication_id_list": "15950780;22673903", "class_list": "", "function": "Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (By similarity). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (By similarity). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (By similarity). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (By similarity). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (By similarity). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (By similarity). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48;2.3.1.-;2.3.1.286;3.4.22.-;3.9.1.-;3.6.4.10;2.1.1.-;2.7.11.1;2.7.11.4;2.3.1.259;2.1.1.319;3.5.1.-;3.5.1.98;2.3.1.80", "go_molecular_function": "GO:0001093 TFIIB-class transcription factor binding;GO:0061733 protein-lysine-acetyltransferase activity;GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060355 positive regulation of cell adhesion molecule production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002931 response to ischemia;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6JHU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62753-1", "uniprot_id": "STXB2_RAT", "mass": 66696.0, "length": 594, "protein_name": "Syntaxin-binding protein 2", "gene_name": "Stxbp2", "organism": "Rat", "refseq_name": "syntaxin-binding protein 2 isoform 1", "refseq_ac": "NP_112388", "gene_names_uniprotkb": "Stxbp2; Unc18b", "gene_names_refseq": "Munc18b; Stxbp2", "protein_names_uniprotkb": "Syntaxin-binding protein 2; Munc18-2; Protein unc-18 homolog 2; Protein unc-18 homolog B; Unc-18B; Unc18-2", "protein_names_refseq": "munc18-2; protein unc-18 homolog 2; protein unc-18 homolog B; syntaxin binding protein Munc18-2; syntaxin-binding protein 2 isoform 1; unc-18 homolog 2; unc-18 homolog B; unc-18B; unc18-2", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 4 (Disease Ontology:DOID:0080436); familial hemophagocytic lymphohistiocytosis 5 (Disease Ontology:DOID:0110925); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:81804); (R-RNO-114608); (R-RNO-449836)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12058058;24323579;24835618;28163042;30127032;34857632;7768895", "class_list": "", "function": "Binds to granuphilin and controls exocytosis of pancreatic beta cells, [RefSeq, PubMed]; Data show that Munc18b overexpression increased fusion of not only newcomer secretory granule (SG), but also predocked SGs in type-2 diabetes (T2D) human and Goto-Kakizaki Rat Islets., [RefSeq, PubMed]; Functions in intracellular vesicle trafficking through interaction with SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) which are essential proteins for membrane fusion. By promoting the assembly of functional STX11/SNAP23/VAMP8 SNARE complexes at the plasma membrane, regulates cytotoxic granule exocytosis in natural killer (NK) cells., [UniProtKB, UniProtKB]; Munc18-2 and STX3 perform distinct, but complementary, functions to support, respectively, SG translocation and membrane fusion in mast cells., [RefSeq, PubMed]; Munc18-dependent and -independent clustering of syntaxin in the plasma membrane of cultured endocrine cells., [RefSeq, PubMed]; SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins, [RefSeq, PubMed]; Secretory vesicles dock by inducing syntaxin1/munc18 clustering in the target membrane. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0030348 syntaxin-3 binding;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0030141 secretory granule;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043312 neutrophil degranulation;GO:0043306 positive regulation of mast cell degranulation;GO:0071346 cellular response to type II interferon;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62753-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QX78-1", "uniprot_id": "SOCS1_RAT", "mass": 23826.0, "length": 212, "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "Socs1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Socs1", "gene_names_refseq": "", "protein_names_uniprotkb": "Suppressor of cytokine signaling 1; SOCS-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); alcoholic hepatitis (Disease Ontology:DOID:12351); hyperinsulinism (Disease Ontology:DOID:2018); transient cerebral ischemia (Disease Ontology:DOID:224); laryngeal carcinoma (Disease Ontology:DOID:2600); asthma (Disease Ontology:DOID:2841); invasive ductal carcinoma (Disease Ontology:DOID:3008); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); esophageal cancer (Disease Ontology:DOID:5041); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:252971); (R-RNO-6785807); (R-RNO-877300); (R-RNO-877312); (R-RNO-909733); (R-RNO-9705462); (R-RNO-983168)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005126 cytokine receptor binding;GO:0019210 kinase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0032496 response to lipopolysaccharide;GO:0035556 intracellular signal transduction;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9QX78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P6G7-1", "uniprot_id": "RLP24_RAT", "mass": 19653.0, "length": 163, "protein_name": "Probable ribosome biogenesis protein RLP24", "gene_name": "Rsl24d1", "organism": "Rat", "refseq_name": "probable ribosome biogenesis protein RLP24", "refseq_ac": "NP_001014234", "gene_names_uniprotkb": "Rsl24d1", "gene_names_refseq": "RGD1309784; Rsl24d1", "protein_names_uniprotkb": "Probable ribosome biogenesis protein RLP24; Ribosomal L24 domain-containing protein 1", "protein_names_refseq": "60S ribosomal protein L30 isolog; homolog of yeast ribosomal like protein 24; my024 protein; probable ribosome biogenesis protein RLP24; ribosomal L24 domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:363099)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P6G7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMK8-1", "uniprot_id": "VPS54_RAT", "mass": 108842.0, "length": 965, "protein_name": "Vacuolar protein sorting-associated protein 54", "gene_name": "Vps54", "organism": "Rat", "refseq_name": "vacuolar protein sorting-associated protein 54", "refseq_ac": "NP_775170", "gene_names_uniprotkb": "Vps54; Vps54l", "gene_names_refseq": "Vps54; Vsp54", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 54; Vps54-like protein", "protein_names_refseq": "VPS54 GARP complex subunit; vacuolar protein sorting 54 homolog; vacuolar protein sorting-associated protein 54; vps54-like protein", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Werdnig-Hoffmann disease (Disease Ontology:DOID:13137); motor neuron disease (Disease Ontology:DOID:231)", "pathway": " (rno:286932); (R-RNO-6811440)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12039048;29393594;31721635", "class_list": "", "function": "Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000938 GARP complex;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0010992 ubiquitin recycling;GO:0071393 cellular response to progesterone stimulus;GO:0030149 sphingolipid catabolic process;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JMK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QX05-1", "uniprot_id": "TLR4_RAT", "mass": 96072.0, "length": 835, "protein_name": "Toll-like receptor 4", "gene_name": "Tlr4", "organism": "Rat", "refseq_name": "toll-like receptor 4 precursor", "refseq_ac": "NP_062051", "gene_names_uniprotkb": "Tlr4", "gene_names_refseq": "Tlr4", "protein_names_uniprotkb": "Toll-like receptor 4; Toll4", "protein_names_refseq": "toll-like receptor 4 precursor; toll4", "tax_id": 10116, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); sinusitis (Disease Ontology:DOID:0050127); alcohol dependence (Disease Ontology:DOID:0050741); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); ileitis (Disease Ontology:DOID:0060189); mastoiditis (Disease Ontology:DOID:0060322); respiratory allergy (Disease Ontology:DOID:0060496); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); herpes simplex virus keratitis (Disease Ontology:DOID:0080158); meningococcal meningitis (Disease Ontology:DOID:0080176); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); urinary tract infection (Disease Ontology:DOID:0080784); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); hymenolepiasis (Disease Ontology:DOID:10074); dry eye syndrome (Disease Ontology:DOID:10140); dermatomyositis (Disease Ontology:DOID:10223); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); mastitis (Disease Ontology:DOID:10690); primary open angle glaucoma (Disease Ontology:DOID:1070); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); cholesteatoma of middle ear (Disease Ontology:DOID:10964); pulpitis (Disease Ontology:DOID:11121); anogenital venereal wart (Disease Ontology:DOID:11168); allergic conjunctivitis (Disease Ontology:DOID:11204); sciatic neuropathy (Disease Ontology:DOID:11446); suppurative otitis media (Disease Ontology:DOID:11506); hepatorenal syndrome (Disease Ontology:DOID:11823); tympanosclerosis (Disease Ontology:DOID:1214); vitiligo (Disease Ontology:DOID:12306); alcoholic hepatitis (Disease Ontology:DOID:12351); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); carotid stenosis (Disease Ontology:DOID:13001); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); low tension glaucoma (Disease Ontology:DOID:13544); exfoliation syndrome (Disease Ontology:DOID:13641); familial combined hyperlipidemia (Disease Ontology:DOID:13809); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); cystic echinococcosis (Disease Ontology:DOID:1495); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); acute kidney failure (Disease Ontology:DOID:3021); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); glucose metabolism disease (Disease Ontology:DOID:4194); macular degeneration (Disease Ontology:DOID:4448); allergic rhinitis (Disease Ontology:DOID:4481); keratitis (Disease Ontology:DOID:4677); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); eye disease (Disease Ontology:DOID:5614); uric acid nephrolithiasis (Disease Ontology:DOID:580); myocardial infarction (Disease Ontology:DOID:5844); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); arthritis (Disease Ontology:DOID:848); lung disease (Disease Ontology:DOID:850); collagen disease (Disease Ontology:DOID:854); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); cholesteatoma (Disease Ontology:DOID:869); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29260); (R-RNO-140534); (R-RNO-166016); (R-RNO-166166); (R-RNO-2562578); (R-RNO-5686938); (R-RNO-936964); (R-RNO-937041); (R-RNO-937072); (R-RNO-9707616); (R-RNO-975163); (R-RNO-9824878)", "pathway_count": 12, "publication_count": 7, "publication_id_list": "10430608;30980393;38195088;38299431;38403153;38788361;38850784", "class_list": "", "function": "Echinatin alleviates inflammation and pyroptosis in hypoxic-ischemic brain damage by inhibiting TLR4/ NF-kappaB pathway., [RefSeq, PubMed]; Excessive hypercholesterolemia in pregnancy impairs rat uterine artery function via activation of Toll-like receptor 4., [RefSeq, PubMed]; MiR-708-5p deficiency involves the degeneration of mandibular condylar chondrocytes via the TLR4/NF-kappaB pathway., [RefSeq, PubMed]; Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent., [RefSeq, PubMed]; The involvement of oxidative stress and the TLR4/NF-kappaB/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia., [RefSeq, PubMed]; Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade. In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86. Upon ligand binding, such as oxLDL or amyloid-beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway. In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14-dependent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 15, "predicted_n_glycosites": 15, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 91, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0043032 positive regulation of macrophage activation;GO:0032700 negative regulation of interleukin-17 production;GO:0002246 wound healing involved in inflammatory response;GO:0002730 regulation of dendritic cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QX05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63493-1", "uniprot_id": "CD1D_RAT", "mass": 38542.0, "length": 336, "protein_name": "Antigen-presenting glycoprotein CD1d", "gene_name": "Cd1d1; Cd1d", "organism": "Rat", "refseq_name": "antigen-presenting glycoprotein CD1d precursor", "refseq_ac": "NP_058775", "gene_names_uniprotkb": "Cd1d1; Cd1d; Cd1d1", "gene_names_refseq": "Cd1d1; Cd1d; Cd1", "protein_names_uniprotkb": "Antigen-presenting glycoprotein CD1d", "protein_names_refseq": "CD1D antigen; CD1d1 antigen; T-cell surface glycoprotein CD1d; antigen-presenting glycoprotein CD1d precursor; antigen-presenting glycoprotein CD1d", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); dengue hemorrhagic fever (Disease Ontology:DOID:12206); urinary schistosomiasis (Disease Ontology:DOID:1394); pulmonary tuberculosis (Disease Ontology:DOID:2957); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (rno:25109); (R-RNO-198933)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21454685;7517972;9601940", "class_list": "", "function": "Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0042608 T cell receptor binding;GO:0030883 endogenous lipid antigen binding;GO:0030884 exogenous lipid antigen binding;GO:0071723 lipopeptide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0051135 positive regulation of NK T cell activation;GO:0006955 immune response;GO:0045087 innate immune response;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63493-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q75Q40-1", "uniprot_id": "TOM40_RAT", "mass": 37919.0, "length": 361, "protein_name": "Mitochondrial import receptor subunit TOM40 homolog", "gene_name": "Tomm40", "organism": "Rat", "refseq_name": "mitochondrial import receptor subunit TOM40 homolog", "refseq_ac": "NP_997685", "gene_names_uniprotkb": "Tomm40; Tom40a; Tom40", "gene_names_refseq": "OM38; TOM40; Tomm40", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM40 homolog; Mitochondrial outer membrane protein of 38 kDa; OM38; Translocase of outer membrane 40 kDa subunit homolog", "protein_names_refseq": "mitochondrial import receptor subunit TOM40 homolog; mitochondrial outer membrane protein of 38 kDa; outer membrane protein 38 kDa; translocase of outer membrane 40 kDa subunit homolog; translocase of outer mitochondrial membrane 40 homolog", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); cerebral infarction (Disease Ontology:DOID:3526)", "pathway": " (rno:308416); (R-RNO-5205685)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10980201;15347672;19401463;30121780;30296408", "class_list": "", "function": "Channel-forming protein that forms part of the translocase of the outer mitochondrial membrane (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:10980201, PubMed:15347672, PubMed:19401463). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Interaction between Tom40 and presequence peptides is mainly electrostatic in nature, [RefSeq, PubMed]; The role of miR-126 and TOMM40 in heat stressed cardiomyocytes, is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015288 porin activity;GO:0005261 monoatomic cation channel activity;GO:0070678 preprotein binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006626 protein targeting to mitochondrion;GO:0030150 protein import into mitochondrial matrix;GO:0051204 protein insertion into mitochondrial membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q75Q40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WF4-1", "uniprot_id": "T132A_RAT", "mass": 110574.0, "length": 1021, "protein_name": "Transmembrane protein 132A", "gene_name": "Tmem132a", "organism": "Rat", "refseq_name": "transmembrane protein 132A isoform 2 precursor", "refseq_ac": "NP_821140", "gene_names_uniprotkb": "Tmem132a; Gbp; Hspa5bp1", "gene_names_refseq": "Gbp; Hspa5bp1; Tmem132a", "protein_names_uniprotkb": "Transmembrane protein 132A; GRP78-binding protein; HSPA5-binding protein 1", "protein_names_refseq": "GRP78-binding protein; HSPA5-binding protein 1; heat shock 70kDa protein 5 binding protein 1; transmembrane protein 132A isoform 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:338474); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12401520;12514190;16806201;16955111;17567751;19662369;38843836", "class_list": "", "function": "Cloning and characterization of GRP78-binding protein that plays a role in embryonic and postnatal development of the brain, [RefSeq, PubMed]; ER stress proteins (GRP78 and ORP150), respectively) were upregulated at PTCs in experimental proteinuric rats., [RefSeq, PubMed]; GRP78 in astroglia could strongly chelate with Pb ions., [RefSeq, PubMed]; GRP78 is involved in IL-6 secretion from astrocytes, and lead can block IL-6 secretion from astrocytes via targeting GRP78, [RefSeq, PubMed]; May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation., [UniProtKB, PubMed, PubMed]; Mitochondrial calcium-mediated reactive oxygen species are essential for the rapid transactivation of the grp78 gene., [RefSeq, PubMed]; These results suggest a novel function of GBP in regulating GFAP gene expression via STAT3 phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070301 cellular response to hydrogen peroxide;GO:0043069 negative regulation of programmed cell death;GO:0042177 negative regulation of protein catabolic process;GO:0061357 positive regulation of Wnt protein secretion;GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80WF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNK7-1", "uniprot_id": "RHAG_RAT", "mass": 49062.0, "length": 450, "protein_name": "Ammonium transporter Rh type A", "gene_name": "Rhag", "organism": "Rat", "refseq_name": "ammonium transporter Rh type A", "refseq_ac": "NP_075411", "gene_names_uniprotkb": "Rhag; LOC100361616; Rh50", "gene_names_refseq": "Rh50; Rhag", "protein_names_uniprotkb": "Ammonium transporter Rh type A; Erythrocyte membrane glycoprotein Rh50; Rh family type A glycoprotein; Rh type A glycoprotein; Rhesus blood group family type A glycoprotein", "protein_names_refseq": "Rhesus blood group-associated A glycoprotein-like; Rhesus blood group-associated A glycoprotein; ammonium transporter Rh type A; erythrocyte membrane glycoprotein Rh50; glycoprotein 50kD; rh family type A glycoprotein; rh type A glycoprotein; rhesus blood group family type A glycoprotein", "tax_id": 10116, "disease": "Rh deficiency syndrome (Disease Ontology:DOID:0050641); overhydrated hereditary stomatocytosis (Disease Ontology:DOID:0111562); hemolytic anemia (Disease Ontology:DOID:583)", "pathway": " (rno:65207); (R-RNO-1237044); (R-RNO-1247673); (R-RNO-444411)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "16227429;16641100;9705835", "class_list": "", "function": "Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Heterotrimer with RHCE (RHAG)2(RHCE), that transports ammonium and its related derivative methylammonium, in both neutral and ionic forms, across the erythrocyte membrane. The transport of NH4(+) is electrogenic and masks the NH3 transport. Also, may act as a CO2 channel. Moreover in erythrocyte, regulates RHD membrane expression and is associated with rhesus blood group antigen expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O88300", "ec_number_list": "", "go_molecular_function": "GO:0008519 ammonium channel activity;GO:0035379 carbon dioxide transmembrane transporter activity;GO:0030506 ankyrin binding;GO:0022840 leak channel activity;GO:0015200 methylammonium transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0170014 ankyrin-1 complex", "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0055085 transmembrane transport;GO:0015670 carbon dioxide transport;GO:0035378 carbon dioxide transmembrane transport;GO:0048821 erythrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TNK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIL8-1", "uniprot_id": "RAD50_RAT", "mass": 153784.0, "length": 1312, "protein_name": "DNA repair protein RAD50", "gene_name": "Rad50", "organism": "Rat", "refseq_name": "DNA repair protein RAD50", "refseq_ac": "NP_071582", "gene_names_uniprotkb": "Rad50", "gene_names_refseq": "Rad50", "protein_names_uniprotkb": "DNA repair protein RAD50; 3.6.-.-", "protein_names_refseq": "DNA repair protein RAD50; RAD50 homolog, double strand break repair protein", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); invasive ductal carcinoma (Disease Ontology:DOID:3008); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:64012); (R-RNO-2559586); (R-RNO-5685938); (R-RNO-5685939); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5693548); (R-RNO-5693565); (R-RNO-5693568); (R-RNO-5693571); (R-RNO-5693579); (R-RNO-5693607); (R-RNO-5693616); (R-RNO-6804756); (R-RNO-69473)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "10908350", "class_list": "", "function": "Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination. Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (By similarity). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR. The MRN complex is also required for the processing of R-loops. In telomeres the MRN complex may modulate t-loop formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;6.5.1.1;3.6.4.13;2.3.2.26;3.6.4.12;3.1.3.48;2.7.7.7;3.1.-.-;1.14.11.69;1.14.11.66;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;2.4.2.-;3.6.5.-;3.4.19.-;5.6.2.-;2.7.7.49;5.6.2.1;2.1.1.357;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.11.-;3.1.3.1;3.9.1.1;6.1.1.12;2.4.2.30;3.6.1.-;2.7.11.24;3.1.3.16;2.3.2.-;3.1.22.-;2.7.4.3;2.7.11.22;3.1.4.-;3.4.24.-;3.6.-.-;2.7.11.17;2.4.99.18;3.4.21.53;2.3.1.48;2.3.1.-;5.6.2.5;2.3.2.23", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0007507 heart development;GO:0000723 telomere maintenance;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JIL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z137-1", "uniprot_id": "B3GA2_RAT", "mass": 37220.0, "length": 324, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2", "gene_name": "B3gat2", "organism": "Rat", "refseq_name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 precursor", "refseq_ac": "NP_072131", "gene_names_uniprotkb": "B3gat2; Glcats", "gene_names_refseq": "B3gat2", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2; 2.4.1.135; Beta-1,3-glucuronyltransferase 2; GlcAT-D; GlcAT-S; Glucuronosyltransferase S; UDP-glucuronosyltransferase S", "protein_names_refseq": "UDP-glucuronosyltransferase S; galactoside beta-1,3-glucuronyltransferase; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 precursor; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2; glcAT-D; glcAT-S; glucuronosyltransferase S", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (rno:64544)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10082676;10358066", "class_list": "glycogene;glycosyltransferase", "function": "Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Substrates include asialo-orosomucoid (ASOR), paragloboside (lacto-N-neotetraosylceramide), Gal-beta-1,4-GlcNAc-beta-1,3-Gal-beta-1,4-Glc-pyridylamine and Gal-beta-1,3-GlcNAc-beta-1,3-Gal-beta-1,4-Glc-pyridylamine., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.135", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0005975 carbohydrate metabolic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 21, "hit_score": 0.3, "record_id": "Q9Z137-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P752-1", "uniprot_id": "TOIP2_RAT", "mass": 61698.0, "length": 578, "protein_name": "Torsin-1A-interacting protein 2", "gene_name": "Tor1aip2", "organism": "Rat", "refseq_name": "torsin-1A-interacting protein 2 isoform b", "refseq_ac": "NP_954531", "gene_names_uniprotkb": "Tor1aip2", "gene_names_refseq": "Tor1aip2", "protein_names_uniprotkb": "Torsin-1A-interacting protein 2", "protein_names_refseq": "interferon alpha responsive protein; torsin A interacting protein 2; torsin-1A-interacting protein 2 isoform b", "tax_id": 10116, "disease": "", "pathway": " (rno:304881)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0061024 membrane organization;GO:0032781 positive regulation of ATP-dependent activity;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P752-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8N7M5-1", "uniprot_id": "RGMC_RAT", "mass": 45221.0, "length": 422, "protein_name": "Hemojuvelin", "gene_name": "Hjv", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Hjv; Hfe2; Rgmc", "gene_names_refseq": "", "protein_names_uniprotkb": "Hemojuvelin; Hemochromatosis type 2 protein homolog; Hemojuvelin BMP coreceptor; RGM domain family member C", "protein_names_refseq": "", "tax_id": 10116, "disease": "hemochromatosis type 2A (Disease Ontology:DOID:0111027); hemochromatosis (Disease Ontology:DOID:2352)", "pathway": " (rno:310681)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14647275", "class_list": "", "function": "Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0036122 BMP binding;GO:1990459 transferrin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0098797 plasma membrane protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0030509 BMP signaling pathway;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8N7M5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923X6-1", "uniprot_id": "TAA7E_RAT", "mass": 40217.0, "length": 358, "protein_name": "Trace amine-associated receptor 7e", "gene_name": "Taar7e", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Taar7e; Ta14; Tar14; Trar14", "gene_names_refseq": "", "protein_names_uniprotkb": "Trace amine-associated receptor 7e; TaR-14; TaR-7e; Trace amine receptor 14; Trace amine receptor 7e", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:294133)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11459929", "class_list": "", "function": "Olfactory receptor specific for N,N-dimethylalkylamines trace amines. Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors. Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q923X6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923X5-1", "uniprot_id": "TAA7D_RAT", "mass": 40653.0, "length": 358, "protein_name": "Trace amine-associated receptor 7d", "gene_name": "Taar7d", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Taar7d; Ta15; Tar15; Trar15", "gene_names_refseq": "", "protein_names_uniprotkb": "Trace amine-associated receptor 7d; TaR-15; TaR-7d; Trace amine receptor 15; Trace amine receptor 7d", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:294134)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11459929;22545963;37225986", "class_list": "", "function": "Olfactory receptor specific for N,N-dimethylalkylamines trace amines, such as N,N-dimethylcyclohexylamine (PubMed:22545963). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:22545963). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q923X5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIB5-1", "uniprot_id": "CCD86_RAT", "mass": 38585.0, "length": 341, "protein_name": "Coiled-coil domain-containing protein 86", "gene_name": "Ccdc86", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 86", "refseq_ac": "NP_001006975", "gene_names_uniprotkb": "Ccdc86; Cyclon", "gene_names_refseq": "Ccdc86", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 86; Cytokine-induced protein with coiled-coil domain", "protein_names_refseq": "coiled-coil domain-containing protein 86; cyclon; cytokine-induced protein with coiled-coil domain", "tax_id": 10116, "disease": "", "pathway": " (rno:293738)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17300783;22673903;29393594", "class_list": "", "function": "Required for proper chromosome segregation during mitosis and error-free mitotic progression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0007059 chromosome segregation;GO:0140014 mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5XIB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIJ9-1", "uniprot_id": "SCO2A_RAT", "mass": 56900.0, "length": 520, "protein_name": "Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial", "gene_name": "Oxct2a", "organism": "Rat", "refseq_name": "succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor", "refseq_ac": "NP_001012221", "gene_names_uniprotkb": "Oxct2a", "gene_names_refseq": "Oxct2a; Oxct2b; SCOT-t1", "protein_names_uniprotkb": "Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; 2.8.3.5; 3-oxoacid CoA-transferase 2A; SCOT-t1; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1", "protein_names_refseq": "3-oxoacid CoA-transferase 2A; rCG31267-like; succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor; succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:366463); (R-RNO-77108)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19423663;20025965", "class_list": "", "function": "Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa (By similarity)., [UniProtKB]; Succinyl-CoA:3-ketoacid CoA transferase in rat kidney mitochondria is affected by age and caloric restriction, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.3.5", "go_molecular_function": "GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031514 motile cilium", "go_biological_process": "GO:0046952 ketone body catabolic process;GO:1902224 ketone body metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XIJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIK2-1", "uniprot_id": "TMX2_RAT", "mass": 33866.0, "length": 295, "protein_name": "Thioredoxin-related transmembrane protein 2", "gene_name": "Tmx2", "organism": "Rat", "refseq_name": "thioredoxin-related transmembrane protein 2 precursor", "refseq_ac": "NP_001007644", "gene_names_uniprotkb": "Tmx2; Txndc14", "gene_names_refseq": "Tmx2", "protein_names_uniprotkb": "Thioredoxin-related transmembrane protein 2; Thioredoxin domain-containing protein 14", "protein_names_refseq": "thioredoxin domain-containing protein 14; thioredoxin-related transmembrane protein 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:295701)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5XIK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIL0-1", "uniprot_id": "RN167_RAT", "mass": 38216.0, "length": 349, "protein_name": "E3 ubiquitin-protein ligase RNF167", "gene_name": "Rnf167", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF167 precursor", "refseq_ac": "NP_001008362", "gene_names_uniprotkb": "Rnf167", "gene_names_refseq": "RGD1305972; Rnf167", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF167; 2.3.2.27; RING finger protein 167", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF167 precursor; E3 ubiquitin-protein ligase RNF167; RING-type E3 ubiquitin transferase RNF167", "tax_id": 10116, "disease": "", "pathway": " (rno:360554)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway. Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1. Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex. Also involved in protein trafficking and localization. Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2. Does not catalyze ubiquitination of GluA1/GRIA1. Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3. Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B. Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18. Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0045786 negative regulation of cell cycle;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIL3-1", "uniprot_id": "RPC3_RAT", "mass": 60543.0, "length": 533, "protein_name": "DNA-directed RNA polymerase III subunit RPC3", "gene_name": "Polr3c", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerase III subunit RPC3", "refseq_ac": "NP_001012081", "gene_names_uniprotkb": "Polr3c", "gene_names_refseq": "Polr3c", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC3; DNA-directed RNA polymerase III subunit C; RNA polymerase III subunit C3", "protein_names_refseq": "DNA-directed RNA polymerase III subunit C; DNA-directed RNA polymerase III subunit RPC3; RNA polymerase III subunit C3; polymerase (RNA) III (DNA directed) polypeptide C; polymerase (RNA) III subunit C", "tax_id": 10116, "disease": "", "pathway": " (rno:310685); (R-RNO-76061); (R-RNO-76066); (R-RNO-76071)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0045089 positive regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIR4-1", "uniprot_id": "CCD33_RAT", "mass": 87764.0, "length": 775, "protein_name": "Coiled-coil domain-containing protein 33", "gene_name": "Ccdc33", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 33 isoform 1", "refseq_ac": "NP_001014113", "gene_names_uniprotkb": "Ccdc33", "gene_names_refseq": "Ccdc33", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 33", "protein_names_refseq": "coiled-coil domain-containing protein 33 isoform 1; coiled-coil domain-containing protein 33", "tax_id": 10116, "disease": "", "pathway": " (rno:315712)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62636-1", "uniprot_id": "RAP1B_RAT", "mass": 20798.0, "length": 184, "protein_name": "Ras-related protein Rap-1b", "gene_name": "Rap1b", "organism": "Rat", "refseq_name": "ras-related protein Rap-1b precursor", "refseq_ac": "NP_599173", "gene_names_uniprotkb": "Rap1b", "gene_names_refseq": "Rap1b", "protein_names_uniprotkb": "Ras-related protein Rap-1b; 3.6.5.2; GTP-binding protein smg p21B", "protein_names_refseq": "GTP-binding protein smg p21B; RAS related protein 1b; ras-related protein Rap-1b precursor; ras-related protein Rap-1b", "tax_id": 10116, "disease": "thrombocytopenia (Disease Ontology:DOID:1588)", "pathway": " (rno:171337); (R-RNO-354192); (R-RNO-354194); (R-RNO-372708); (R-RNO-392517); (R-RNO-5674135); (R-RNO-6798695); (R-RNO-8875555)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "11959997;12089143;24165023;25935485", "class_list": "", "function": "CAMP inhibits Akt via Rap1b, [RefSeq, PubMed]; Data indicate that mutations at different sites affect the ability of rap GTP-Binding Protein Rap1 to activate appropriately., [RefSeq, PubMed]; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity)., [UniProtKB, UniProtKB]; On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b., [RefSeq, PubMed]; Specific activation of Rap1B contributes to neuronal polarization via interaction with RalA and Nore1A in addition to PI3-kinase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6J167", "ec_number_list": "3.6.5.2;2.7.11.1;3.6.1.1;3.6.5.-;7.6.2.1;3.6.5.3;2.3.2.27;3.4.16.2;3.6.5.5;2.7.10.2;3.6.1.5;2.5.1.18;3.1.3.48;3.1.3.5;3.1.3.2;2.7.11.24;2.7.10.4;2.7.12.2;3.6.4.-;2.7.10.1;3.4.23.-;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;3.2.1.25;3.5.1.92;3.6.1.-;3.6.5.4;3.2.1.20", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62636-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62760-1", "uniprot_id": "TOM20_RAT", "mass": 16284.0, "length": 145, "protein_name": "Mitochondrial import receptor subunit TOM20 homolog", "gene_name": "Tomm20", "organism": "Rat", "refseq_name": "mitochondrial import receptor subunit TOM20 homolog", "refseq_ac": "NP_690918", "gene_names_uniprotkb": "Tomm20", "gene_names_refseq": "Tomm20", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM20 homolog; Mitochondrial 20 kDa outer membrane protein; Outer mitochondrial membrane receptor Tom20", "protein_names_refseq": "mitochondrial 20 kDa outer membrane protein; mitochondrial import receptor subunit TOM20 homolog; outer mitochondrial membrane receptor Tom20; outer mitochondrial membrane receptor rTOM20; translocase of outer mitochondrial membrane 20 homolog", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:266601); (R-RNO-5205685); (R-RNO-5689880)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10721992;19401463;22673903;27280685;28100784;29934347", "class_list": "", "function": "Alpha-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease, [RefSeq, PubMed]; Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with TOMM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (PubMed:19401463)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08517;Q63804;Q6AZ66", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0015450 protein-transporting ATPase activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005741 mitochondrial outer membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0071944 cell periphery", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006626 protein targeting to mitochondrion;GO:0014850 response to muscle activity;GO:0030150 protein import into mitochondrial matrix;GO:1905242 response to 3,3',5-triiodo-L-thyronine", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62760-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62834-1", "uniprot_id": "CD123_RAT", "mass": 38812.0, "length": 336, "protein_name": "Translation initiation factor eIF2 assembly protein", "gene_name": "Cdc123", "organism": "Rat", "refseq_name": "translation initiation factor eIF2 assembly protein", "refseq_ac": "NP_446329", "gene_names_uniprotkb": "Cdc123; D123", "gene_names_refseq": "Cdc123; D123", "protein_names_uniprotkb": "Translation initiation factor eIF2 assembly protein; Cell division cycle protein 123 homolog; Protein D123", "protein_names_refseq": "D123 gene product; cell division cycle 123 homolog; cell division cycle protein 123 homolog; translation initiation factor eIF2 assembly protein", "tax_id": 10116, "disease": "", "pathway": " (rno:116656)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10698258;11699637;8601400;9683532", "class_list": "", "function": "ATP-dependent protein-folding chaperone for the eIF2 complex (By similarity). Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; ATP-dependent protein-folding chaperone for the eIF2 complex. Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The D123 protein is unstable in the temperature-sensitive cell-cycle mutant of the rat 3Y1 fibroblast cell line., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0044183 protein folding chaperone;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1905143 eukaryotic translation initiation factor 2 complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62834-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62865-1", "uniprot_id": "PDE3A_RAT", "mass": 124301.0, "length": 1141, "protein_name": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A", "gene_name": "Pde3a", "organism": "Rat", "refseq_name": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A", "refseq_ac": "NP_059033", "gene_names_uniprotkb": "Pde3a", "gene_names_refseq": "Pde3a; RNPDE3A", "protein_names_uniprotkb": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A; 3.1.4.17; CGI-PDE A; Cyclic GMP-inhibited phosphodiesterase A", "protein_names_refseq": "CGI-PDE A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cyclic GMP-inhibited phosphodiesterase A; cyclic nucleotide phosphodiesterase; phosphodiesterase 3A, cGMP inhibited", "tax_id": 10116, "disease": "hypertension and brachydactyly syndrome (Disease Ontology:DOID:0111247); pulmonary hypertension (Disease Ontology:DOID:6432); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:50678); (R-RNO-418555)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "22673903;27975297;31401933;32524868;36259389;37296663;9631240", "class_list": "", "function": "CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms. Publication Status: Online-Only, [RefSeq, PubMed]; Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Also has activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling., [UniProtKB, UniProtKB]; High cGMP and low PDE3A activity are associated with oocyte meiotic incompetence., [RefSeq, PubMed]; Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage., [RefSeq, PubMed]; PDE3A is a low-affinity and high-velocity enzyme for hydrolysis of cUMP in cardiac myocytes., [RefSeq, PubMed]; Phosphodiesterase 3A and Arterial Hypertension., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.-;3.1.4.53;3.1.4.35;3.1.4.17;3.6.1.1;3.6.1.25;3.6.1.14;3.1.4.1;3.6.1.9", "go_molecular_function": "GO:0004119 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity;GO:0046872 metal ion binding;GO:0030284 nuclear estrogen receptor activity;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0060282 positive regulation of oocyte development;GO:0043066 negative regulation of apoptotic process;GO:0043116 negative regulation of vascular permeability;GO:0097190 apoptotic signaling pathway;GO:0071560 cellular response to transforming growth factor beta stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62865-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62885-1", "uniprot_id": "U119A_RAT", "mass": 27048.0, "length": 240, "protein_name": "Protein unc-119 homolog A", "gene_name": "Unc119", "organism": "Rat", "refseq_name": "protein unc-119 homolog A", "refseq_ac": "NP_058884", "gene_names_uniprotkb": "Unc119; Rg4", "gene_names_refseq": "RRG4; Unc119; Uncl19", "protein_names_uniprotkb": "Protein unc-119 homolog A; Retinal protein 4; rRG4", "protein_names_refseq": "UNC-119 homolog; protein unc-119 homolog A; retinal gene 4; retinal protein 4", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); cone-rod dystrophy 24 (Disease Ontology:DOID:0081449); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); immunodeficiency 13 (Disease Ontology:DOID:0111987); prostate cancer (Disease Ontology:DOID:10283); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); crescentic glomerulonephritis (Disease Ontology:DOID:13139); interstitial cystitis (Disease Ontology:DOID:13949); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); chondrosarcoma (Disease Ontology:DOID:3371); middle cerebral artery infarction (Disease Ontology:DOID:3525); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); end stage renal disease (Disease Ontology:DOID:783); kidney angiomyolipoma (Disease Ontology:DOID:8411); vascular dementia (Disease Ontology:DOID:8725); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29402)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12527357;22673903;8576185", "class_list": "", "function": "Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0051233 spindle midzone;GO:0045171 intercellular bridge", "go_biological_process": "GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0042953 lipoprotein transport;GO:0061098 positive regulation of protein tyrosine kinase activity;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62885-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62928-1", "uniprot_id": "PE2R2_RAT", "mass": 39772.0, "length": 357, "protein_name": "Prostaglandin E2 receptor EP2 subtype", "gene_name": "Ptger2", "organism": "Rat", "refseq_name": "prostaglandin E2 receptor EP2 subtype", "refseq_ac": "NP_112350", "gene_names_uniprotkb": "Ptger2", "gene_names_refseq": "EP2; Ptger-ep2; Ptger2", "protein_names_uniprotkb": "Prostaglandin E2 receptor EP2 subtype; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Prostanoid EP2 receptor", "protein_names_refseq": "PGE receptor, EP2 subtype; PGE2 receptor EP2 subtype; prostaglandin E receptor 2 (subtype EP2); prostaglandin E receptor EP2 subtype; prostaglandin E2 receptor EP2 subtype-like; prostaglandin E2 receptor EP2 subtype; prostaglandin E2 receptor type 2; prostanoid EP2 receptor", "tax_id": 10116, "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); asthma, nasal polyps, and aspirin intolerance (Disease Ontology:DOID:0111579); heart disease (Disease Ontology:DOID:114); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung squamous cell carcinoma (Disease Ontology:DOID:3907)", "pathway": " (rno:81752); (R-RNO-391908)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "29393594;36889213;9440134;9537820", "class_list": "", "function": "Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle (By similarity)., [UniProtKB]; Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q547S0", "ec_number_list": "", "go_molecular_function": "GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1904346 positive regulation of gastric mucosal blood circulation;GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62928-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62931-1", "uniprot_id": "GOSR1_RAT", "mass": 28534.0, "length": 250, "protein_name": "Golgi SNAP receptor complex member 1", "gene_name": "Gosr1", "organism": "Rat", "refseq_name": "Golgi SNAP receptor complex member 1", "refseq_ac": "NP_446036", "gene_names_uniprotkb": "Gosr1; Gs28", "gene_names_refseq": "GOS28; Gosr1; p28", "protein_names_uniprotkb": "Golgi SNAP receptor complex member 1; 28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; GOS-28; GOS28", "protein_names_refseq": "28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; GOS-28; Golgi SNAP receptor complex member 1; cis-Golgi p28 (p28)", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:94189); (R-RNO-6807878); (R-RNO-6811438)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10585748;10747018;11323436;11748249;11927603;12388752;14742712;15728195;18648846;20450495;8638159;9094723;9382863;9647643", "class_list": "", "function": "Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN01", "ec_number_list": "", "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005797 Golgi medial cisterna", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0006906 vesicle fusion;GO:0048219 inter-Golgi cisterna vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q62931-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62968-1", "uniprot_id": "SCNAA_RAT", "mass": 219733.0, "length": 1956, "protein_name": "Sodium channel protein type 10 subunit alpha", "gene_name": "Scn10a", "organism": "Rat", "refseq_name": "sodium channel protein type 10 subunit alpha", "refseq_ac": "NP_058943", "gene_names_uniprotkb": "Scn10a; Sns", "gene_names_refseq": "Na(V)1.8; Nav1.8; PN3; Scn10a", "protein_names_uniprotkb": "Sodium channel protein type 10 subunit alpha; PN3; Peripheral nerve sodium channel 3; Sensory neuron sodium channel; Sodium channel protein type X subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.8", "protein_names_refseq": "peripheral nerve sodium channel 3; sensory neuron sodium channel; sodium channel protein type 10 subunit alpha; sodium channel protein type X subunit alpha; sodium channel type X alpha polypeptide; sodium channel voltage-gated type X alpha polypeptide; sodium channel, voltage-gated, type 10, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.8", "tax_id": 10116, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); familial episodic pain syndrome 2 (Disease Ontology:DOID:0111730); sciatic neuropathy (Disease Ontology:DOID:11446); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:29571)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11487631;12050667;12514212;12591166;15047701;15178439;27631681;27905525;30860870;33998011;34798136;38843836;8538791;8626372;9450690", "class_list": "", "function": "A Low-Frequency Pulsed Magnetic Field Reduces Neuropathic Pain by Regulating NaV1.8 and NaV1.9 Sodium Channels at the Transcriptional Level in Diabetic Rats., [RefSeq, PubMed]; Magi-1 bound to sequence like a calcium-activated potassium channel sodium-activated (Slack) potassium channels, demonstrating macrocomplexing with NaV1.8 channels. NaV1.8 expression decreased after Magi-1 knockdown in vivo., [RefSeq, PubMed]; Spinal cord injury-mediated changes in electrophysiological properties of rat gastric nodose ganglion neurons., [RefSeq, PubMed]; Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms., [UniProtKB, PubMed, PubMed, PubMed]; This study demonstrated the modulation of Nav1.8 by LPA in DRG neurons, and that this probably underlies the peripheral mechanism by which bone cancer pain is induced., [RefSeq, PubMed]; Treatment of AOAA markedly suppressed expression of NaV1.7 and NaV1.8 in DRGs of lumbar disc herniation (LDH) rats. These data suggest that targeting the CBS-H2S signaling at the DRG level might represent a novel therapeutic strategy for chronic pain relief in patients with LDH. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q63554;Q6EWG6", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential;GO:0005248 voltage-gated sodium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0042734 presynaptic membrane;GO:0044299 C-fiber", "go_biological_process": "GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0086010 membrane depolarization during action potential;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q62968-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63132-1", "uniprot_id": "ROS1_RAT", "mass": 261656.0, "length": 2338, "protein_name": "Proto-oncogene tyrosine-protein kinase ROS", "gene_name": "Ros1", "organism": "Rat", "refseq_name": "proto-oncogene tyrosine-protein kinase ROS precursor", "refseq_ac": "NP_037006", "gene_names_uniprotkb": "Ros1", "gene_names_refseq": "ROS1C; Ros1", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase ROS; 2.7.10.1; Proto-oncogene c-Ros-1; Proto-oncogene c-Ros; Receptor tyrosine kinase c-ros oncogene 1; c-Ros receptor tyrosine kinase", "protein_names_refseq": "Ros1 proto-oncogene; c-Ros receptor tyrosine kinase; c-ros oncogene 1, receptor tyrosine kinase; c-ros-1; heart - derived c - ros - 1 proto - oncogene; proto-oncogene c-Ros-1; proto-oncogene tyrosine-protein kinase ROS precursor; proto-oncogene tyrosine-protein kinase ROS-like; proto-oncogene tyrosine-protein kinase ROS; receptor tyrosine kinase c-ros oncogene 1; v-ros UR2 sarcoma virus oncogene homolog 1", "tax_id": 10116, "disease": "", "pathway": " (rno:25346)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17187413;2139140;28770648", "class_list": "", "function": "Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Uric acid plays an important role in CVD pathogenesis by inducing inflammatory COX-2 and ROS pathways. This is the first study demonstrating losartan's ability to reduce uric-acid-induced COX-2 elevation., [RefSeq, PubMed]; We identified novel cell surface markers specific for hepatic progenitor/oval cells. Six are unique for the adult progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp)., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q63130;Q63131", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.10.2;2.7.12.2;2.7.1.40;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.32;2.7.1.82;2.7.11.23", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019903 protein phosphatase binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0010966 regulation of phosphate transport;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63132-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63377-1", "uniprot_id": "AT1B3_RAT", "mass": 31830.0, "length": 279, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-3", "gene_name": "Atp1b3", "organism": "Rat", "refseq_name": "sodium/potassium-transporting ATPase subunit beta-3", "refseq_ac": "NP_037045", "gene_names_uniprotkb": "Atp1b3", "gene_names_refseq": "Atp1b3; NKAB3S", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-3; ATPB-3; Sodium/potassium-dependent ATPase subunit beta-3", "protein_names_refseq": "ATPB-3; ATPase, Na+/K+ transporting, beta 3 polypeptide; ATPase, Na+K+ transporting, beta polypeptide 3; Na+/K+ -ATPase beta 3 subunit; sodium/potassium-dependent ATPase subunit beta-3; sodium/potassium-transporting ATPase subunit beta-3", "tax_id": 10116, "disease": "familial adult myoclonic epilepsy 5 (Disease Ontology:DOID:0111691); epilepsy (Disease Ontology:DOID:1826); high grade glioma (Disease Ontology:DOID:3070); T-cell adult acute lymphocytic leukemia (Disease Ontology:DOID:5602); lung disease (Disease Ontology:DOID:850)", "pathway": " (rno:25390); (R-RNO-210991); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "12562669;14749213;21454685;9950762", "class_list": "", "function": "Chronic heart failure-induced alterations in skeletal muscle Na(+)-K(+)-ATPase, including B(max) and isoform expression, can be partially reversed by exercise training., [RefSeq, PubMed]; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051117 ATPase binding;GO:0001671 ATPase activator activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity;GO:0141109 transporter activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0042470 melanosome", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0050821 protein stabilization;GO:0006883 intracellular sodium ion homeostasis;GO:0006813 potassium ion transport;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63377-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63467-1", "uniprot_id": "TFF1_RAT", "mass": 9155.0, "length": 81, "protein_name": "Trefoil factor 1", "gene_name": "Tff1", "organism": "Rat", "refseq_name": "trefoil factor 1 precursor", "refseq_ac": "NP_476470", "gene_names_uniprotkb": "Tff1; Ps2", "gene_names_refseq": "Ps2; Tff1", "protein_names_uniprotkb": "Trefoil factor 1; Protein pS2", "protein_names_refseq": "protein pS2; trefoil factor 1 precursor", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); colitis (Disease Ontology:DOID:0060180); endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); signet ring cell adenocarcinoma (Disease Ontology:DOID:3493); cervical adenocarcinoma (Disease Ontology:DOID:3702); ovarian carcinoma (Disease Ontology:DOID:4001)", "pathway": " (rno:117270)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24116124;24588600;26459015;39142164;8836141", "class_list": "", "function": "Data indicate that trefoil factor 1 (TFF1) expression is restricted to neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Distinct populations of cultured dopaminergic neurons express trefoil factor 1, and their numbers can be increased by factors known to influence survival and differentiation of dopaminergic cells., [RefSeq, PubMed]; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents., [UniProtKB]; Substantial amounts of TFF1 were detected only in the cytoplasm of epithelial cells in the submandibular glands granular convoluted tubules (GCT), while TFF2 and TFF3 were widely distributed in the cytoplasm of epithelial cells of intercalated ducts, [RefSeq, PubMed]; Trefoil factor 1 (TFF1) reduces cerebral edema and gastric mucosal injury by regulating the EGFR/Src/FAK pathway in an intracerebral hemorrhage rat model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0030277 maintenance of gastrointestinal epithelium;GO:0043434 response to peptide hormone;GO:0010039 response to iron ion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63467-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63486-1", "uniprot_id": "RRAGA_RAT", "mass": 36566.0, "length": 313, "protein_name": "Ras-related GTP-binding protein A", "gene_name": "Rraga", "organism": "Rat", "refseq_name": "ras-related GTP-binding protein A", "refseq_ac": "NP_446425", "gene_names_uniprotkb": "Rraga", "gene_names_refseq": "Raga; Rraga", "protein_names_uniprotkb": "Ras-related GTP-binding protein A; 3.6.5.-; Rag A; RagA", "protein_names_refseq": "Ras-related GTP-binding protein ragA; rag A; ras-related GTP-binding protein A", "tax_id": 10116, "disease": "ragopathy (Disease Ontology:DOID:0061140)", "pathway": " (rno:117044); (R-RNO-1632852); (R-RNO-165159); (R-RNO-166208); (R-RNO-380972); (R-RNO-5628897); (R-RNO-8866654); (R-RNO-8943724); (R-RNO-9639288)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "7499430", "class_list": "", "function": "Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;7.1.2.2;2.3.2.27;2.7.11.1;2.1.1.-;3.6.5.5;3.6.1.5;2.7.10.2;2.7.11.26;2.7.11.31;3.6.1.-;5.2.1.8;3.6.5.4;2.3.2.23", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process;GO:0042593 glucose homeostasis;GO:0010507 negative regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63486-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63487-1", "uniprot_id": "RRAGB_RAT", "mass": 43191.0, "length": 374, "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RragB; Rragb", "organism": "Rat", "refseq_name": "ras-related GTP-binding protein B", "refseq_ac": "NP_446424", "gene_names_uniprotkb": "RragB; Rragb; RragB", "gene_names_refseq": "Ragb; Rragb", "protein_names_uniprotkb": "Ras-related GTP-binding protein B; 3.6.5.-; Rag B; RagB", "protein_names_refseq": "GTP-binding protein ragB; rag B; ras-related GTP-binding protein B", "tax_id": 10116, "disease": "ragopathy (Disease Ontology:DOID:0061140)", "pathway": " (rno:117043); (R-RNO-1632852); (R-RNO-165159); (R-RNO-166208); (R-RNO-380972); (R-RNO-5628897); (R-RNO-8943724); (R-RNO-9639288)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "7499430", "class_list": "", "function": "Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AZ37", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;7.1.2.2;2.3.2.27;2.7.11.1;2.1.1.-;3.6.5.5;3.6.1.5;2.7.10.2;2.7.11.26;2.7.11.31;3.6.1.-;5.2.1.8;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0051020 GTPase binding;GO:0032561 guanyl ribonucleotide binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:1990131 Gtr1-Gtr2 GTPase complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0010507 negative regulation of autophagy;GO:0032008 positive regulation of TOR signaling;GO:0008104 intracellular protein localization;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63487-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63528-1", "uniprot_id": "RFA2_RAT", "mass": 29346.0, "length": 270, "protein_name": "Replication protein A 32 kDa subunit", "gene_name": "Rpa2", "organism": "Rat", "refseq_name": "replication protein A 32 kDa subunit isoform 1", "refseq_ac": "NP_067593", "gene_names_uniprotkb": "Rpa2", "gene_names_refseq": "Rpa2", "protein_names_uniprotkb": "Replication protein A 32 kDa subunit; RF-A protein 2; RP-A p32; Replication factor A protein 2", "protein_names_refseq": "RF-A protein 2; RP-A p32; p32-subunit of replication protein A; replication factor A protein 2; replication protein A 32 kDa subunit isoform 1; replication protein A 32 kDa subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:59102); (R-RNO-110312); (R-RNO-110314); (R-RNO-110320); (R-RNO-174437); (R-RNO-176187); (R-RNO-3371453); (R-RNO-5358565); (R-RNO-5358606); (R-RNO-5651801); (R-RNO-5655862); (R-RNO-5656121); (R-RNO-5656169); (R-RNO-5685938); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5693607); (R-RNO-5696395); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6783310); (R-RNO-6804756); (R-RNO-68962); (R-RNO-69166); (R-RNO-69473)", "pathway_count": 27, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6AY60", "ec_number_list": "", "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0003684 damaged DNA binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016605 PML body;GO:0000785 chromatin", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006284 base-excision repair;GO:0000723 telomere maintenance;GO:0006260 DNA replication;GO:0006298 mismatch repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q63528-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63540-1", "uniprot_id": "ATX1_RAT", "mass": 83501.0, "length": 789, "protein_name": "Ataxin-1", "gene_name": "Atxn1", "organism": "Rat", "refseq_name": "ataxin-1", "refseq_ac": "NP_036858", "gene_names_uniprotkb": "Atxn1; Sca1", "gene_names_refseq": "Atxn1; Sca1", "protein_names_uniprotkb": "Ataxin-1; Spinocerebellar ataxia type 1 protein homolog", "protein_names_refseq": "ataxin-1; spinocerebellar ataxia 1; spinocerebellar ataxia type 1 protein homolog", "tax_id": 10116, "disease": "spinocerebellar ataxia 1 (Disease Ontology:DOID:0050954); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (rno:25049)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31375326;8852664", "class_list": "", "function": "Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved brain development., [UniProtKB, UniProtKB, UniProtKB]; The possibility that CrCDC and Sca-1(+) cells rather than c-Kit(+) cells may be used therapeutically to preserve cardiac function and energy metabolism after myocardial infarction., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0031208 POZ domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63540-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63645-1", "uniprot_id": "PAR2_RAT", "mass": 44441.0, "length": 397, "protein_name": "Proteinase-activated receptor 2", "gene_name": "F2rl1", "organism": "Rat", "refseq_name": "proteinase-activated receptor 2 precursor", "refseq_ac": "NP_446349", "gene_names_uniprotkb": "F2rl1; Par2", "gene_names_refseq": "F2rl1; Par-2; Par2", "protein_names_uniprotkb": "Proteinase-activated receptor 2; Coagulation factor II receptor-like 1; PAR-2; Thrombin receptor-like 1", "protein_names_refseq": "Proteinase-activated receptor-2, G protein-coupled receptor 11; coagulation factor II (thrombin) receptor-like 1; coagulation factor II receptor-like 1; proteinase-activated receptor 2 precursor; proteinase-activated receptor 2; thrombin receptor-like 1", "tax_id": 10116, "disease": "respiratory allergy (Disease Ontology:DOID:0060496); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung disease (Disease Ontology:DOID:850)", "pathway": " (rno:116677); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11884377;17693410;35637468;36657618;36791026;37811618;37838226;8762073", "class_list": "", "function": "Effects of PAR2 Gene Knockout on Visceral Sensitivity, Stress Behaviors, and Colonic Electrical Activities in Irritable Bowel Syndrome., [RefSeq, PubMed]; Endothelial PAR2 activation evokes resistance artery relaxation., [RefSeq, PubMed]; Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway. Publication Status: Online-Only, [RefSeq, PubMed]; PAR2 Overexpression is Involved in the Occurrence of Hyperoxygen-Induced Bronchopulmonary Dysplasia in Rats., [RefSeq, PubMed]; PAR2-dependent phosphorylation of TRPV4 at the trigeminal nerve terminals contributes to tongue cancer pain., [RefSeq, PubMed]; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates Tlr3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (By similarity). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o)-alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF stimulated JNK phosphorylation via coupling to G GNAQ and GNA11; the function involves dissociation of RIPK1 and Tradd from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves Ikbkb and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by Cops5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as pro-inflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses (By similarity). Probably mediates activation of pro-inflammatory and pro-fibrotic responses in fibroblasts, triggered by coagulation factor Xa (F10) (By similarity). Probably mediates activation of barrier protective signaling responses in endothelial cells, triggered by coagulation factor Xa (F10) (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q499T9", "ec_number_list": "", "go_molecular_function": "GO:0015057 thrombin-activated receptor activity;GO:0031681 G-protein beta-subunit binding;GO:0002020 protease binding;GO:0004930 G protein-coupled receptor activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0031143 pseudopodium", "go_biological_process": "GO:0034141 positive regulation of toll-like receptor 3 signaling pathway;GO:0061028 establishment of endothelial barrier;GO:1900135 positive regulation of renin secretion into blood stream;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63645-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63707-1", "uniprot_id": "PYRD_RAT", "mass": 42663.0, "length": 395, "protein_name": "Dihydroorotate dehydrogenase (quinone), mitochondrial", "gene_name": "Dhodh", "organism": "Rat", "refseq_name": "dihydroorotate dehydrogenase (quinone), mitochondrial precursor", "refseq_ac": "NP_001008553", "gene_names_uniprotkb": "Dhodh", "gene_names_refseq": "Dhodh", "protein_names_uniprotkb": "Dihydroorotate dehydrogenase (quinone), mitochondrial; 1.3.5.2; DHOdehase; Dihydroorotate oxidase", "protein_names_refseq": "DHOdehase; dihydroorotate dehydrogenase (quinone), mitochondrial precursor; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate dehydrogenase, mitochondrial; dihydroorotate oxidase", "tax_id": 10116, "disease": "postaxial acrofacial dysostosis (Disease Ontology:DOID:0111259)", "pathway": " (rno:65156); (R-RNO-500753)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10727948;15044733;15571246;20544541;7660999", "class_list": "", "function": "Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells of different species, [RefSeq, PubMed]; High levels of both DHODH activity and immunoreactivity were observed in the neocortex, hippocampus, spinal cord and choroid plexus; lower levels were seen in the cerebellum, and only marginal expression in brainstem, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.5.2", "go_molecular_function": "GO:0004151 dihydroorotase activity;GO:0048038 quinone binding;GO:0010181 FMN binding;GO:0004152 dihydroorotate dehydrogenase activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043025 neuronal cell body;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0009220 pyrimidine ribonucleotide biosynthetic process;GO:1903576 response to L-arginine;GO:0042594 response to starvation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63707-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63750-1", "uniprot_id": "RM23_RAT", "mass": 17050.0, "length": 146, "protein_name": "Large ribosomal subunit protein uL23m", "gene_name": "Mrpl23", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL23m", "refseq_ac": "NP_071974", "gene_names_uniprotkb": "Mrpl23; L23mrp", "gene_names_refseq": "Mrpl23; Rpl23-rs; Rpl23l; rL23MRP", "protein_names_uniprotkb": "Large ribosomal subunit protein uL23m; 39S ribosomal protein L23, mitochondrial; L23 mitochondrial-related protein; L23mt; MRP-L23", "protein_names_refseq": "39S ribosomal protein L23, mitochondrial; L23 mitochondrial-related protein; L23mt; MRP-L23; large ribosomal subunit protein uL23m; ribosomal protein L23-related product homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:64360); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0022626 cytosolic ribosome;GO:0044391 ribosomal subunit", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q63750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63942-1", "uniprot_id": "RAB3D_RAT", "mass": 24290.0, "length": 219, "protein_name": "GTP-binding protein Rab-3D", "gene_name": "Rab3d", "organism": "Rat", "refseq_name": "GTP-binding protein Rab-3D", "refseq_ac": "NP_542147", "gene_names_uniprotkb": "Rab3d; Rab16", "gene_names_refseq": "Rab3d", "protein_names_uniprotkb": "GTP-binding protein Rab-3D; 3.6.5.2", "protein_names_refseq": "GTP-binding protein Rab-3D", "tax_id": 10116, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:140665); (R-RNO-6798695); (R-RNO-8873719)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1313420;21080055;22367855;7508866;7532276;9300704;9716267", "class_list": "", "function": "Rab3D is not involved in agonist-induced exocytosis in AR42J cells. Instead, Rab3D may regulate amylase content in these cells., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3D may be involved in the insulin-induced exocytosis of GLUT4-containing vesicles in adipocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These data suggest an implication of myosin Va and Rab3D in the maturation of SGs where they participate in overlapping but not identical tasks., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P35291", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;7.6.2.1;3.6.5.3;2.3.2.27;3.4.16.2;2.7.11.1;3.6.5.5;3.6.1.5;2.5.1.18;3.1.3.5;3.1.3.2;3.1.3.48;3.4.23.-;2.5.1.60;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;3.2.1.25;3.5.1.92;3.6.1.-;3.6.5.4;3.2.1.20", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0030742 GTP-dependent protein binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0042588 zymogen granule;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:1903307 positive regulation of regulated secretory pathway;GO:0015031 protein transport;GO:0045453 bone resorption;GO:0006887 exocytosis;GO:0018125 peptidyl-cysteine methylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63942-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q641W4-1", "uniprot_id": "RFC2_RAT", "mass": 38657.0, "length": 349, "protein_name": "Replication factor C subunit 2", "gene_name": "Rfc2", "organism": "Rat", "refseq_name": "replication factor C subunit 2", "refseq_ac": "NP_446238", "gene_names_uniprotkb": "Rfc2", "gene_names_refseq": "Rfc2", "protein_names_uniprotkb": "Replication factor C subunit 2; Activator 1 subunit C2", "protein_names_refseq": "activator 1 subunit C2; replication factor C (activator 1) 2; replication factor C subunit 2", "tax_id": 10116, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (rno:116468); (R-RNO-110312); (R-RNO-110314); (R-RNO-110320); (R-RNO-174411); (R-RNO-176187); (R-RNO-5651801); (R-RNO-5655862); (R-RNO-5656121); (R-RNO-5656169); (R-RNO-5685938); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5693607); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6804756); (R-RNO-69091); (R-RNO-69473)", "pathway_count": 21, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (By similarity). This subunit binds ATP (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity;GO:0003689 DNA clamp loader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031390 Ctf18 RFC-like complex;GO:0005663 DNA replication factor C complex;GO:0031389 Rad17 RFC-like complex", "go_biological_process": "GO:0006281 DNA repair;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0006261 DNA-templated DNA replication;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q641W4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q641X9-1", "uniprot_id": "RM09_RAT", "mass": 30076.0, "length": 262, "protein_name": "Large ribosomal subunit protein bL9m", "gene_name": "Mrpl9", "organism": "Rat", "refseq_name": "large ribosomal subunit protein bL9m", "refseq_ac": "NP_001007697", "gene_names_uniprotkb": "Mrpl9; mrpl9", "gene_names_refseq": "Mrpl9", "protein_names_uniprotkb": "Large ribosomal subunit protein bL9m; 39S ribosomal protein L9, mitochondrial; L9mt; MRP-L9", "protein_names_refseq": "39S ribosomal protein L9, mitochondrial; L9mt; MRP-L9; large ribosomal subunit protein bL9m", "tax_id": 10116, "disease": "", "pathway": " (rno:310653); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q641X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q642A0-1", "uniprot_id": "PDRG1_RAT", "mass": 15392.0, "length": 133, "protein_name": "p53 and DNA damage-regulated protein 1", "gene_name": "Pdrg1", "organism": "Rat", "refseq_name": "p53 and DNA damage-regulated protein 1", "refseq_ac": "NP_001014762", "gene_names_uniprotkb": "Pdrg1", "gene_names_refseq": "Pdrg1; RGD1305096", "protein_names_uniprotkb": "p53 and DNA damage-regulated protein 1", "protein_names_refseq": "p53 and DNA damage-regulated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:296278)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27548429", "class_list": "", "function": "May play a role in chaperone-mediated protein folding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The oncogene PDRG1 is an interaction target of methionine adenosyltransferases. Erratum:[PLoS One. 2016 Sep 22;11(9):e0163761. doi: 10.1371/journal.pone.0163761. PMID: 27658062] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q642A0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q642A2-1", "uniprot_id": "ATRAP_RAT", "mass": 17398.0, "length": 160, "protein_name": "Type-1 angiotensin II receptor-associated protein", "gene_name": "Agtrap", "organism": "Rat", "refseq_name": "type-1 angiotensin II receptor-associated protein", "refseq_ac": "NP_001007655", "gene_names_uniprotkb": "Agtrap; Atrap", "gene_names_refseq": "Agtrap", "protein_names_uniprotkb": "Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein", "protein_names_refseq": "AT1 receptor-associated protein; angiotensin II, type I receptor-associated protein; type-1 angiotensin II receptor-associated protein", "tax_id": 10116, "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158); hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:298646)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11162453;21576625;22673903;23383303;26018598;37884662", "class_list": "", "function": "A single dose of angiotensin(17) at the same concentration as angiotensin II induced Agtrap gene expression., [RefSeq, PubMed]; AT(1)-AB induces Ang II sensitivity. Our mechanistic study supports the existence of an 'autoimmune-activating receptor' that could contribute to Ang II sensitivity and possible to preeclampsia., [RefSeq, PubMed]; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Attenuates type-1 angiotensin II receptor growth promoting effect and angiotensin II-induced phosphorylation of protein kinase AKT and of STAT3., [UniProtKB, PubMed]; Enhancement of angiotensin II type 1 receptor-associated protein in the paraventricular nucleus suppresses angiotensin II-dependent hypertension., [RefSeq, PubMed]; The expression of both angiotensin AGTRa and AGTR2 receptors was increased in the myocardium of overfed rats, and ischemia-reperfusion increased the expression of both receptors in control rats but reduced it in overfed rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004945 angiotensin type II receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0008217 regulation of blood pressure;GO:0038166 angiotensin-activated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q642A2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q642B3-1", "uniprot_id": "RHBD3_RAT", "mass": 41098.0, "length": 385, "protein_name": "Rhomboid domain-containing protein 3", "gene_name": "Rhbdd3", "organism": "Rat", "refseq_name": "rhomboid domain-containing protein 3", "refseq_ac": "NP_001013897", "gene_names_uniprotkb": "Rhbdd3", "gene_names_refseq": "RGD1311827; Rhbdd3", "protein_names_uniprotkb": "Rhomboid domain-containing protein 3", "protein_names_refseq": "rhomboid domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:289753)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001889 liver development;GO:0000165 MAPK cascade;GO:0045732 positive regulation of protein catabolic process;GO:0050708 regulation of protein secretion;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q642B3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64550-1", "uniprot_id": "UD11_RAT", "mass": 59663.0, "length": 535, "protein_name": "UDP-glucuronosyltransferase 1A1", "gene_name": "Ugt1a1", "organism": "Rat", "refseq_name": "UDP-glucuronosyltransferase 1A1 precursor", "refseq_ac": "NP_036815", "gene_names_uniprotkb": "Ugt1a1; Ugt1", "gene_names_refseq": "UDPGT 1-1; Udpgt; Ugt1a1; Ugt1", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 1A1; 2.4.1.17; B1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UGT1A1", "protein_names_refseq": "B1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1 family member 1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1A1 precursor; UDP-glucuronosyltransferase 1A1; UGT1*1; UGT1-01; UGT1.1", "tax_id": 10116, "disease": "cholelithiasis (Disease Ontology:DOID:10211); cholecystolithiasis (Disease Ontology:DOID:11151); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); hepatitis B (Disease Ontology:DOID:2043); ovarian cancer (Disease Ontology:DOID:2394); Gilbert syndrome (Disease Ontology:DOID:2739); bilirubin metabolic disorder (Disease Ontology:DOID:2741); Crigler-Najjar syndrome (Disease Ontology:DOID:3803); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperthyroidism (Disease Ontology:DOID:7998); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24861); (R-RNO-156588); (R-RNO-189483); (R-RNO-9749641); (R-RNO-9753281)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "29131354;7603447;7608130;7986077;8554318", "class_list": "glycogene;glycosyltransferase", "function": "Study indicated that Status Epilepticus altered the expression of brain Ugt1a1 and Ugt1a7, which could alter glucuronidation in the brain., [RefSeq, PubMed]; UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:8554318). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:8554318). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (By similarity). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (By similarity). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGB1 and F2-isoprostane (8-iso-PGF2alpha). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (By similarity). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (By similarity). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (By similarity). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q64635", "ec_number_list": "2.4.1.17", "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0046685 response to arsenic-containing substance;GO:0035733 hepatic stellate cell activation;GO:0001889 liver development;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64550-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64638-1", "uniprot_id": "UD15_RAT", "mass": 59993.0, "length": 531, "protein_name": "UDP-glucuronosyltransferase 1A5", "gene_name": "Ugt1a5", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ugt1a5; Ugt1", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 1A5; 2.4.1.17; B5; UDP-glucuronosyltransferase 1-5; UDPGT 1-5; UGT1*5; UGT1-05; UGT1.5; UGT1A5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-156588); (R-RNO-189483); (R-RNO-9749641); (R-RNO-9754706); (R-RNO-9757110)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "2112380;7608130", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.17", "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0001889 liver development;GO:0032870 cellular response to hormone stimulus;GO:0071361 cellular response to ethanol;GO:0016125 sterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64638-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64LC9-1", "uniprot_id": "RBM4B_RAT", "mass": 39991.0, "length": 357, "protein_name": "RNA-binding protein 4B", "gene_name": "Rbm4b", "organism": "Rat", "refseq_name": "RNA-binding protein 4B", "refseq_ac": "NP_001007015", "gene_names_uniprotkb": "Rbm4b; Rbm30", "gene_names_refseq": "Rbm4b", "protein_names_uniprotkb": "RNA-binding protein 4B; RNA-binding motif protein 30; RNA-binding motif protein 4B; RNA-binding protein 30; Zinc-responsive protein ZD7", "protein_names_refseq": "RNA-binding motif protein 30; RNA-binding protein 30; RNA-binding protein 4B; zinc-responsive protein ZD7", "tax_id": 10116, "disease": "", "pathway": " (rno:474154)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15361827", "class_list": "", "function": "Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5U1X3", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0010628 positive regulation of gene expression;GO:0007623 circadian rhythm;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64LC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q65Z15-1", "uniprot_id": "ONCM_RAT", "mass": 27106.0, "length": 239, "protein_name": "Oncostatin-M", "gene_name": "Osm", "organism": "Rat", "refseq_name": "oncostatin-M precursor", "refseq_ac": "NP_001006962", "gene_names_uniprotkb": "Osm", "gene_names_refseq": "Osm", "protein_names_uniprotkb": "Oncostatin-M; OSM", "protein_names_refseq": "oncostatin-M precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:289747); (R-RNO-6788467)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15743783;19168167;25986861", "class_list": "", "function": "Findings indicated that OSM induces Mcl-1 expression via activation of ERK1/2, JAK1/2, STAT1/3, and CREB; furthermore, OSM-mediated Mcl-1 induction contributes to bioenergetic improvements, [RefSeq, PubMed]; Functions as a cytokine that uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST) (By similarity). Functionally, regulates many processes including cell proliferation, cell differentiation, cytokine production (PubMed:15743783). Mechanistically, low affinity ligand binding to IL6ST/gp130, induces heterodimerization with LIFR or OSMR, activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR or OSMR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of STAT3. The type II OSM complex receptor is also able in addition to STAT3 to recruit STAT5B. Moreover, the type II OSM complex receptor recruits SHC1 through OSMR in a JAK1 mediated phosphotyrosine-dependent manner, leading to SHC1 association with GRB2 and downstream activation of the Ras/Raf/MAPK pathway (By similarity)., [UniProtKB, UniProtKB, PubMed]; Results indicate that osteosarcoma cells stably producing OSM do not develop resistance to this cytokine and thus could be a valuable new tool to study the anti-cancer effect of OSM in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005147 oncostatin-M receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0038165 oncostatin-M-mediated signaling pathway;GO:0032740 positive regulation of interleukin-17 production;GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0033138 positive regulation of peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q65Z15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H47-1", "uniprot_id": "RM24_RAT", "mass": 25001.0, "length": 216, "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "Mrpl24", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL24m", "refseq_ac": "NP_001007638", "gene_names_uniprotkb": "Mrpl24", "gene_names_refseq": "Mrpl24", "protein_names_uniprotkb": "Large ribosomal subunit protein uL24m; 39S ribosomal protein L24, mitochondrial; L24mt; MRP-L24", "protein_names_refseq": "39S ribosomal protein L24, mitochondrial; L24mt; MRP-L24; large ribosomal subunit protein uL24m", "tax_id": 10116, "disease": "", "pathway": " (rno:295224); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H60-1", "uniprot_id": "CC146_RAT", "mass": 114645.0, "length": 974, "protein_name": "Coiled-coil domain-containing protein 146", "gene_name": "Ccdc146", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 146", "refseq_ac": "NP_001020215", "gene_names_uniprotkb": "Ccdc146", "gene_names_refseq": "Ccdc146", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 146", "protein_names_refseq": "coiled-coil domain-containing protein 146", "tax_id": 10116, "disease": "spermatogenic failure 94 (Disease Ontology:DOID:0070593); male infertility (Disease Ontology:DOID:12336)", "pathway": " (rno:499980)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Essential for sperm flagellum biogenesis and male fertility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005856 cytoskeleton;GO:0036126 sperm flagellum;GO:0005814 centriole;GO:0005930 axoneme", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008283 cell population proliferation;GO:0030317 flagellated sperm motility;GO:0000902 cell morphogenesis;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H88-1", "uniprot_id": "PLPP6_RAT", "mass": 31700.0, "length": 293, "protein_name": "Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6", "gene_name": "Plpp6", "organism": "Rat", "refseq_name": "polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6", "refseq_ac": "NP_001030026", "gene_names_uniprotkb": "Plpp6", "gene_names_refseq": "Plpp6; Ppapdc2", "protein_names_uniprotkb": "Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; 3.1.3.-; 3.6.1.-; 3.6.1.68; Phospholipid phosphatase 6", "protein_names_refseq": "phosphatidic acid phosphatase type 2 domain containing 2; phosphatidic acid phosphatase type 2 domain-containing protein 2; polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; presqualene diphosphate phosphatase", "tax_id": 10116, "disease": "", "pathway": " (rno:619549); (R-RNO-9969896)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.1.9;3.6.1.68;3.6.1.76;3.1.3.-;3.1.3.4;3.1.3.106;3.6.1.75;3.6.1.58;3.6.1.-", "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0016787 hydrolase activity;GO:0008195 phosphatidate phosphatase activity;GO:0042577 lipid phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0042632 cholesterol homeostasis;GO:0006720 isoprenoid metabolic process;GO:0018342 protein prenylation;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66HG8-1", "uniprot_id": "RED_RAT", "mass": 65588.0, "length": 557, "protein_name": "Protein Red", "gene_name": "Ik", "organism": "Rat", "refseq_name": "protein Red", "refseq_ac": "NP_001005537", "gene_names_uniprotkb": "Ik", "gene_names_refseq": "CSA2; Ik; RED", "protein_names_uniprotkb": "Protein Red; Cytokine IK; IK factor", "protein_names_refseq": "IK cytokine, down-regulator of HLA II; Ik factor; chondrosarcoma-associated protein 2; cytokine IK; protein Red", "tax_id": 10116, "disease": "", "pathway": " (rno:291659)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species. Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0097431 mitotic spindle pole;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0000398 mRNA splicing, via spliceosome;GO:0034501 protein localization to kinetochore", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q67ER9-1", "uniprot_id": "T2R39_RAT", "mass": 36420.0, "length": 319, "protein_name": "Taste receptor type 2 member 39", "gene_name": "Tas2r39", "organism": "Rat", "refseq_name": "taste receptor type 2 member 39", "refseq_ac": "NP_001074374", "gene_names_uniprotkb": "Tas2r39; Tas2r139; Tas2r32", "gene_names_refseq": "Tas2r139; Tas2r39", "protein_names_uniprotkb": "Taste receptor type 2 member 39; T2R32; T2R39; Taste receptor type 2 member 139; Taste receptor type 2 member 32", "protein_names_refseq": "T2R39; putative taste receptor T2R32; taste receptor type 2 member 32; taste receptor type 2 member 39; taste receptor, type 2, member 39", "tax_id": 10116, "disease": "", "pathway": " (rno:680188); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ER9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q67ET0-1", "uniprot_id": "TA2R4_RAT", "mass": 34811.0, "length": 304, "protein_name": "Taste receptor type 2 member 4", "gene_name": "Tas2r4", "organism": "Rat", "refseq_name": "taste receptor type 2 member 4", "refseq_ac": "NP_001019857", "gene_names_uniprotkb": "Tas2r4; T2r16; T2r20; Tas2r108", "gene_names_refseq": "T2R16; Tas2r108; Tas2r4", "protein_names_uniprotkb": "Taste receptor type 2 member 4; T2R16; T2R20; T2R4; Taste receptor type 2 member 108; Taste receptor type 2 member 20", "protein_names_refseq": "T2R20; T2R4; bitter taste receptor T2R16; taste receptor type 2 member 20; taste receptor type 2 member 4", "tax_id": 10116, "disease": "", "pathway": " (rno:554302); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15886333", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0060170 ciliary membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q67ET0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68A21-1", "uniprot_id": "PURB_RAT", "mass": 33418.0, "length": 315, "protein_name": "Transcriptional regulator protein Pur-beta", "gene_name": "ENSRNOG00000062895; Purb", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ENSRNOG00000062895; Purb; ENSRNOG00000062895; Purb", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcriptional regulator protein Pur-beta; Purine-rich element-binding protein B", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:498407)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11032866;12933792;16309856;18683930;22673903", "class_list": "", "function": "Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' flanking region of the gene. Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC- specific isoforms. Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes. Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene (By similarity). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element (PubMed:12933792). Modulates constitutive liver galectin-3 gene transcription by binding to its promoter (PubMed:16309856). May play a role in the dendritic transport of a subset of mRNAs (PubMed:11032866)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q68A21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUQ1-1", "uniprot_id": "ATS1_RAT", "mass": 105706.0, "length": 967, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 1", "gene_name": "Adamts1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Adamts1", "gene_names_refseq": "", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 1; 3.4.24.-; ADAM-TS 1; ADAM-TS1; ADAMTS-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); ureteral obstruction (Disease Ontology:DOID:5199); urinary tract obstruction (Disease Ontology:DOID:5200); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:79252); (R-RNO-5173214)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10847486", "class_list": "", "function": "Metalloprotease which cleaves aggrecan, a cartilage proteoglycan, at the '1683-Glu-|-Leu-1684' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Also cleaves COMP. Has angiogenic inhibitor activity. May play a critical role in follicular rupture., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERI1", "ec_number_list": "2.4.1.221;3.4.24.87;3.4.24.-;3.4.24.82", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0031410 cytoplasmic vesicle;GO:0005604 basement membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0010976 positive regulation of neuron projection development;GO:0030198 extracellular matrix organization;GO:0001822 kidney development;GO:0071380 cellular response to prostaglandin E stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WUQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FP5-1", "uniprot_id": "SPN1_RAT", "mass": 40964.0, "length": 358, "protein_name": "Snurportin-1", "gene_name": "Snupn", "organism": "Rat", "refseq_name": "snurportin-1", "refseq_ac": "NP_001004270", "gene_names_uniprotkb": "Snupn; Rnut1", "gene_names_refseq": "Rnut1; Snupn", "protein_names_uniprotkb": "Snurportin-1; RNA U transporter 1", "protein_names_refseq": "RNA U transporter 1; snurportin-1", "tax_id": 10116, "disease": "autosomal recessive limb-girdle muscular dystrophy type 29 (Disease Ontology:DOID:0061134); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274)", "pathway": " (rno:316108); (R-RNO-191859)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000339 RNA cap binding;GO:0061608 nuclear import signal receptor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005846 nuclear cap binding complex", "go_biological_process": "GO:0061015 snRNA import into nucleus;GO:0051259 protein complex oligomerization;GO:0051262 protein tetramerization;GO:0007010 cytoskeleton organization;GO:0006404 RNA import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FQ7-1", "uniprot_id": "RPAP3_RAT", "mass": 74645.0, "length": 659, "protein_name": "RNA polymerase II-associated protein 3", "gene_name": "Rpap3", "organism": "Rat", "refseq_name": "RNA polymerase II-associated protein 3", "refseq_ac": "NP_001004243", "gene_names_uniprotkb": "Rpap3", "gene_names_refseq": "Rpap3", "protein_names_uniprotkb": "RNA polymerase II-associated protein 3", "protein_names_refseq": "RNA polymerase II-associated protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:300189)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005829 cytosol;GO:0101031 protein folding chaperone complex;GO:1990062 RPAP3/R2TP/prefoldin-like complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q68FQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FU0-1", "uniprot_id": "TM174_RAT", "mass": 26478.0, "length": 243, "protein_name": "Transmembrane protein 174", "gene_name": "Tmem174", "organism": "Rat", "refseq_name": "transmembrane protein 174", "refseq_ac": "NP_001019469", "gene_names_uniprotkb": "Tmem174", "gene_names_refseq": "Tmem174", "protein_names_uniprotkb": "Transmembrane protein 174", "protein_names_refseq": "transmembrane protein 174", "tax_id": 10116, "disease": "", "pathway": " (rno:499516)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulator of plasma phosphate homeostasis. Decreases serum inorganic phosphate (Pi) uptake by regulating the sodium-phosphate cotransporter SLC34A1 trafficking by PTH and FGF23 in the kidney., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0055062 phosphate ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FU8-1", "uniprot_id": "SUGP1_RAT", "mass": 72595.0, "length": 644, "protein_name": "SURP and G-patch domain-containing protein 1", "gene_name": "Sugp1", "organism": "Rat", "refseq_name": "SURP and G-patch domain-containing protein 1", "refseq_ac": "NP_001011920", "gene_names_uniprotkb": "Sugp1; Sf4", "gene_names_refseq": "Sf4; Sugp1", "protein_names_uniprotkb": "SURP and G-patch domain-containing protein 1; Splicing factor 4", "protein_names_refseq": "SURP and G-patch domain-containing protein 1; splicing factor 4", "tax_id": 10116, "disease": "", "pathway": " (rno:290666); (R-RNO-9770562)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in pre-mRNA splicing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FV0-1", "uniprot_id": "T178A_RAT", "mass": 33080.0, "length": 297, "protein_name": "Transmembrane protein 178A", "gene_name": "Tmem178a", "organism": "Rat", "refseq_name": "transmembrane protein 178A precursor", "refseq_ac": "NP_001004282", "gene_names_uniprotkb": "Tmem178a; Tmem178", "gene_names_refseq": "Tmem178a; Tmem178", "protein_names_uniprotkb": "Transmembrane protein 178A", "protein_names_refseq": "transmembrane protein 178A precursor; transmembrane protein 178", "tax_id": 10116, "disease": "", "pathway": " (rno:362691)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0045671 negative regulation of osteoclast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FV1-1", "uniprot_id": "TM38B_RAT", "mass": 32445.0, "length": 291, "protein_name": "Trimeric intracellular cation channel type B", "gene_name": "Tmem38b", "organism": "Rat", "refseq_name": "trimeric intracellular cation channel type B", "refseq_ac": "NP_001014213", "gene_names_uniprotkb": "Tmem38b", "gene_names_refseq": "RGD1305703; Tmem38b", "protein_names_uniprotkb": "Trimeric intracellular cation channel type B; TRIC-B; TRICB; Transmembrane protein 38B", "protein_names_refseq": "TRIC-B; TRICB; trimeric intracellular cation channel type B", "tax_id": 10116, "disease": "osteogenesis imperfecta type 14 (Disease Ontology:DOID:0110343)", "pathway": " (rno:362521)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Activated by increased cytosolic Ca(2+) levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0048286 lung alveolus development;GO:0051209 release of sequestered calcium ion into cytosol;GO:0060348 bone development;GO:0001503 ossification;GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FW4-1", "uniprot_id": "STX18_RAT", "mass": 38512.0, "length": 334, "protein_name": "Syntaxin-18", "gene_name": "Stx18", "organism": "Rat", "refseq_name": "syntaxin-18", "refseq_ac": "NP_001012151", "gene_names_uniprotkb": "Stx18", "gene_names_refseq": "Stx18", "protein_names_uniprotkb": "Syntaxin-18", "protein_names_refseq": "syntaxin-18", "tax_id": 10116, "disease": "", "pathway": " (rno:360953); (R-RNO-6811434)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031201 SNARE complex", "go_biological_process": "GO:1902117 positive regulation of organelle assembly;GO:0090158 endoplasmic reticulum membrane organization;GO:0006886 intracellular protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXN9-1", "uniprot_id": "RIBC2_RAT", "mass": 45134.0, "length": 377, "protein_name": "RIB43A-like with coiled-coils protein 2", "gene_name": "Ribc2", "organism": "Rat", "refseq_name": "RIB43A-like with coiled-coils protein 2", "refseq_ac": "NP_001013971", "gene_names_uniprotkb": "Ribc2", "gene_names_refseq": "RGD1309033; Ribc2", "protein_names_uniprotkb": "RIB43A-like with coiled-coils protein 2", "protein_names_refseq": "RIB43A-like with coiled-coils protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:300122)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19103603", "class_list": "", "function": "Expression of Ribc2 exhibits a 24-hour rhythm in the rat pineal gland, with >25-fold higher values occurring at night. These changes appear to reflect neural stimulation and norepinephrine-cyclic AMP signaling., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "R9PXY2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXS2-1", "uniprot_id": "TM252_RAT", "mass": 20193.0, "length": 185, "protein_name": "Transmembrane protein 252", "gene_name": "Tmem252", "organism": "Rat", "refseq_name": "transmembrane protein 252", "refseq_ac": "NP_001007739", "gene_names_uniprotkb": "Tmem252", "gene_names_refseq": "RGD1359349; Tmem252", "protein_names_uniprotkb": "Transmembrane protein 252", "protein_names_refseq": "transmembrane protein 252; transmembrane protein C9orf71 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:361744)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXS9-1", "uniprot_id": "RFLB_RAT", "mass": 23454.0, "length": 216, "protein_name": "Refilin-B", "gene_name": "Rflnb", "organism": "Rat", "refseq_name": "refilin-B", "refseq_ac": "NP_001007612", "gene_names_uniprotkb": "Rflnb; Fam101b", "gene_names_refseq": "Fam101b; RGD1359691; Rflnb", "protein_names_uniprotkb": "Refilin-B; RefilinB; Regulator of filamin protein B", "protein_names_refseq": "family with sequence similarity 101, member B; filamin-interacting protein FAM101B; protein FAM101B; refilin-B; refilinB; regulator of filamin protein B", "tax_id": 10116, "disease": "", "pathway": " (rno:287534)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031005 filamin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0032432 actin filament bundle", "go_biological_process": "GO:1900158 negative regulation of bone mineralization involved in bone maturation;GO:0061572 actin filament bundle organization;GO:0030036 actin cytoskeleton organization;GO:0048705 skeletal system morphogenesis;GO:0001837 epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXU4-1", "uniprot_id": "RN181_RAT", "mass": 19288.0, "length": 165, "protein_name": "E3 ubiquitin-protein ligase RNF181", "gene_name": "Rnf181", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF181", "refseq_ac": "NP_001007648", "gene_names_uniprotkb": "Rnf181", "gene_names_refseq": "Rnf181", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF181; 2.3.2.27; RING finger protein 181", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF181; RING-type E3 ubiquitin transferase RNF181", "tax_id": 10116, "disease": "", "pathway": " (rno:297337); (R-RNO-8866654)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.23;2.3.2.24;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXX6-1", "uniprot_id": "PXL2A_RAT", "mass": 25763.0, "length": 229, "protein_name": "Peroxiredoxin-like 2A", "gene_name": "Prxl2a", "organism": "Rat", "refseq_name": "peroxiredoxin-like 2A", "refseq_ac": "NP_001014162", "gene_names_uniprotkb": "Prxl2a; Fam213a; Pamm; Shp1", "gene_names_refseq": "Fam213a; PAMM; Prxl2a; RGD1309676", "protein_names_uniprotkb": "Peroxiredoxin-like 2A; Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; Protein PAMM; Redox-regulatory protein FAM213A; Sperm head protein 1", "protein_names_refseq": "UPF0765 protein C10orf58 homolog; family with sequence similarity 213, member A; peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; peroxiredoxin-like 2A; redox-regulatory protein FAM213A; redox-regulatory protein PAMM; sperm head protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361118)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19423663;19951071;21454685", "class_list": "", "function": "Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P85300", "ec_number_list": "", "go_molecular_function": "GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0045670 regulation of osteoclast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AXX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXY3-1", "uniprot_id": "TEX29_RAT", "mass": 19940.0, "length": 182, "protein_name": "Testis-expressed protein 29", "gene_name": "Tex29", "organism": "Rat", "refseq_name": "testis-expressed protein 29", "refseq_ac": "NP_001017508", "gene_names_uniprotkb": "Tex29", "gene_names_refseq": "Tex29", "protein_names_uniprotkb": "Testis-expressed protein 29", "protein_names_refseq": "testis-expressed protein 29; testis-expressed sequence 29 protein; uncharacterized protein C13orf16 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:498664)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY01-1", "uniprot_id": "RN133_RAT", "mass": 42872.0, "length": 381, "protein_name": "E3 ubiquitin-protein ligase RNF133", "gene_name": "Rnf133", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF133", "refseq_ac": "NP_001037743", "gene_names_uniprotkb": "Rnf133", "gene_names_refseq": "Rnf133", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF133; 2.3.2.27; RING finger protein 133; RING-type E3 ubiquitin transferase RNF133", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF133; RING-type E3 ubiquitin transferase RNF133", "tax_id": 10116, "disease": "", "pathway": " (rno:681395)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has E3 ubiquitin-protein ligase activity. Plays a role in male fecundity through the interaction with the E2 ubituitin-protein ligase UBE2J1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0005770 late endosome", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY26-1", "uniprot_id": "RHNO1_RAT", "mass": 27070.0, "length": 235, "protein_name": "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1", "gene_name": "Rhno1", "organism": "Rat", "refseq_name": "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1", "refseq_ac": "NP_001388902", "gene_names_uniprotkb": "Rhno1; Rhno1-ps2", "gene_names_refseq": "Rhno1", "protein_names_uniprotkb": "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1", "protein_names_refseq": "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:297627); (R-RNO-5685938); (R-RNO-5693607); (R-RNO-6804756); (R-RNO-69473)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis. MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair double-strand breaks in DNA that originate in S-phase. Accumulates in M-phase; following phosphorylation by PLK1, interacts with POLQ, enabling its recruitment to double-strand breaks for subsequent repair. Also involved in the DNA damage response (DDR) signaling in response to genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0005694 chromosome", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0071479 cellular response to ionizing radiation;GO:0000077 DNA damage checkpoint signaling;GO:0000725 recombinational repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY31-1", "uniprot_id": "CD036_RAT", "mass": 13331.0, "length": 117, "protein_name": "Uncharacterized protein C4orf36 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "uncharacterized protein C4orf36 homolog", "refseq_ac": "NP_001017495", "gene_names_uniprotkb": "", "gene_names_refseq": "Aff1-as1; C14h4orf36", "protein_names_uniprotkb": "Uncharacterized protein C4orf36 homolog", "protein_names_refseq": "AFF1 antisense RNA 1; uncharacterized protein C4orf36 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:498330)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY76-1", "uniprot_id": "TM248_RAT", "mass": 35113.0, "length": 314, "protein_name": "Transmembrane protein 248", "gene_name": "Tmem248", "organism": "Rat", "refseq_name": "transmembrane protein 248", "refseq_ac": "NP_001004204", "gene_names_uniprotkb": "Tmem248", "gene_names_refseq": "Tmem248", "protein_names_uniprotkb": "Transmembrane protein 248", "protein_names_refseq": "UPF0458 protein C7orf42 homolog; transmembrane protein 248", "tax_id": 10116, "disease": "", "pathway": " (rno:288616)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY84-1", "uniprot_id": "SCRN1_RAT", "mass": 46396.0, "length": 414, "protein_name": "Secernin-1", "gene_name": "Scrn1", "organism": "Rat", "refseq_name": "secernin-1", "refseq_ac": "NP_001020234", "gene_names_uniprotkb": "Scrn1", "gene_names_refseq": "Scrn1", "protein_names_uniprotkb": "Secernin-1", "protein_names_refseq": "secernin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:502776)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016805 dipeptidase activity;GO:0070004 cysteine-type exopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0098793 presynapse", "go_biological_process": "GO:0006508 proteolysis;GO:0006887 exocytosis;GO:0098693 regulation of synaptic vesicle cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY96-1", "uniprot_id": "T2FA_RAT", "mass": 57181.0, "length": 508, "protein_name": "General transcription factor IIF subunit 1", "gene_name": "Gtf2f1", "organism": "Rat", "refseq_name": "general transcription factor IIF subunit 1", "refseq_ac": "NP_001007712", "gene_names_uniprotkb": "Gtf2f1", "gene_names_refseq": "Gtf2f1", "protein_names_uniprotkb": "General transcription factor IIF subunit 1; TFIIF-alpha; Transcription initiation factor IIF subunit alpha", "protein_names_refseq": "TFIIF-alpha; general transcription factor IIF subunit 1; general transcription factor IIF, polypeptide 1, 74kDa; transcription initiation factor IIF subunit alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:316123); (R-RNO-112382); (R-RNO-113418); (R-RNO-674695); (R-RNO-6796648); (R-RNO-6803529); (R-RNO-6807505); (R-RNO-72086); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075); (R-RNO-9018519); (R-RNO-9770562)", "pathway_count": 19, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0019903 protein phosphatase binding;GO:0019211 phosphatase activator activity;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex;GO:0005669 transcription factor TFIID complex;GO:0005674 transcription factor TFIIF complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032091 negative regulation of protein binding;GO:0009615 response to virus;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AY96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYB5-1", "uniprot_id": "SRP54_RAT", "mass": 55705.0, "length": 504, "protein_name": "Signal recognition particle subunit SRP54", "gene_name": "Srp54a; Srp54", "organism": "Rat", "refseq_name": "signal recognition particle subunit SRP54", "refseq_ac": "NP_446323", "gene_names_uniprotkb": "Srp54a; Srp54", "gene_names_refseq": "Srp54a; Srp54", "protein_names_uniprotkb": "Signal recognition particle subunit SRP54; 3.6.5.4; Signal recognition particle 54 kDa protein", "protein_names_refseq": "signal recognition particle 54 kDa protein; signal recognition particle subunit SRP54", "tax_id": 10116, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); severe congenital neutropenia 8 (Disease Ontology:DOID:0112135); neutropenia (Disease Ontology:DOID:1227)", "pathway": " (rno:116650); (R-RNO-1799339)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;4.2.99.18;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0030942 endoplasmic reticulum signal peptide binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0043021 ribonucleoprotein complex binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0045047 protein targeting to ER;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0030593 neutrophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYG0-1", "uniprot_id": "MT25B_RAT", "mass": 53023.0, "length": 475, "protein_name": "Methyltransferase-like protein 25B", "gene_name": "Mettl25b", "organism": "Rat", "refseq_name": "methyltransferase-like protein 25B", "refseq_ac": "NP_001014195", "gene_names_uniprotkb": "Mettl25b; Rrnad1", "gene_names_refseq": "Mettl25b; RGD1311265; Rrnad1", "protein_names_uniprotkb": "Methyltransferase-like protein 25B; Protein RRNAD1", "protein_names_refseq": "methyltransferase-like protein 25B; protein RRNAD1; ribosomal RNA adenine dimethylase domain containing 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361976)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYK1-1", "uniprot_id": "RNPS1_RAT", "mass": 34238.0, "length": 305, "protein_name": "RNA-binding protein with serine-rich domain 1", "gene_name": "Rnps1", "organism": "Rat", "refseq_name": "RNA-binding protein with serine-rich domain 1", "refseq_ac": "NP_001011890", "gene_names_uniprotkb": "Rnps1", "gene_names_refseq": "Rnps1", "protein_names_uniprotkb": "RNA-binding protein with serine-rich domain 1", "protein_names_refseq": "RNA binding protein S1; RNA-binding protein with serine-rich domain 1; ribonucleic acid binding protein S1", "tax_id": 10116, "disease": "", "pathway": " (rno:287113); (R-RNO-159236); (R-RNO-72163); (R-RNO-975957)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0061574 ASAP complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398 mRNA splicing, via spliceosome;GO:0050684 regulation of mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYP6-1", "uniprot_id": "SAXO1_RAT", "mass": 53265.0, "length": 462, "protein_name": "Stabilizer of axonemal microtubules 1", "gene_name": "Saxo1", "organism": "Rat", "refseq_name": "stabilizer of axonemal microtubules 1", "refseq_ac": "NP_001014134", "gene_names_uniprotkb": "Saxo1; Fam154a", "gene_names_refseq": "Fam154a; Saxo1; Saxol1", "protein_names_uniprotkb": "Stabilizer of axonemal microtubules 1", "protein_names_refseq": "protein FAM154A; stabilizer of axonemal microtubules 1", "tax_id": 10116, "disease": "", "pathway": " (rno:317471)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005856 cytoskeleton;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0005814 centriole", "go_biological_process": "GO:0070417 cellular response to cold;GO:0050821 protein stabilization;GO:0009631 cold acclimation;GO:0030030 cell projection organization;GO:0045724 positive regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYR8-1", "uniprot_id": "SCRN2_RAT", "mass": 46502.0, "length": 423, "protein_name": "Secernin-2", "gene_name": "Scrn2", "organism": "Rat", "refseq_name": "secernin-2", "refseq_ac": "NP_001012142", "gene_names_uniprotkb": "Scrn2", "gene_names_refseq": "Scrn2", "protein_names_uniprotkb": "Secernin-2", "protein_names_refseq": "secernin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:360612)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016805 dipeptidase activity;GO:0070004 cysteine-type exopeptidase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6BDS1-1", "uniprot_id": "SPI1_RAT", "mass": 31089.0, "length": 271, "protein_name": "Transcription factor PU.1", "gene_name": "Spi1", "organism": "Rat", "refseq_name": "transcription factor PU.1", "refseq_ac": "NP_001005892", "gene_names_uniprotkb": "Spi1; Sfpi1", "gene_names_refseq": "Pu.1; Sfpi1; Spi1", "protein_names_uniprotkb": "Transcription factor PU.1", "protein_names_refseq": "SFFV proviral integration 1; hematopoietic transcription factor PU.1; spleen focus forming virus (SFFV) proviral integration oncogene spi1; spleen focus forming virus proviral integration oncogene spi1; transcription factor PU.1", "tax_id": 10116, "disease": "agammaglobulinemia 10 (Disease Ontology:DOID:0081142); alcohol use disorder (Disease Ontology:DOID:1574); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:366126)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15304324;15688197;25840997;29393594;29482641;33970748;36299239", "class_list": "", "function": "Four upregulated transcription factors Pax6, Tp73, Cebpd, and Spi1, appeared as potent regulators of chronic post-traumatic brain injury (TBI) gene expression. They regulate molecular networks contributing to post-injury secondary damage, including apoptosis and inflammation, strengthening the feasibility of therapeutically targeting these molecular networks even after the acute post-TBI period. Publication Status: Online-Only, [RefSeq, PubMed]; Nrf2 regulates the expression and activity of PU.1 and that antioxidant response and immune activation are coordinately regulated within the AM., [RefSeq, PubMed]; PU.1 interaction with p50 promotes microglial-mediated inflammation in secondary spinal cord injury in SCI rats., [RefSeq, PubMed]; Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R or FCER1A (PubMed:15304324). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (PubMed:15304324). May be particularly important for the pro- to pre-B cell transition. Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (By similarity). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Salmonella pathogenicity island 1 knockdown confers protection against myocardial fibrosis and inflammation in uremic cardiomyopathy via down-regulation of S100 Calcium Binding Protein A8/A9 transcription., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BK69", "ec_number_list": "", "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0051525 NFAT protein binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0002573 myeloid leukocyte differentiation;GO:0030851 granulocyte differentiation;GO:1904238 pericyte cell differentiation;GO:0002327 immature B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6BDS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GV27-1", "uniprot_id": "TM225_RAT", "mass": 26598.0, "length": 231, "protein_name": "Transmembrane protein 225", "gene_name": "Tmem225", "organism": "Rat", "refseq_name": "transmembrane protein 225", "refseq_ac": "NP_001019530", "gene_names_uniprotkb": "Tmem225; Pmp22cd", "gene_names_refseq": "Pmp22cd; Tmem225", "protein_names_uniprotkb": "Transmembrane protein 225", "protein_names_refseq": "PMP22 claudin domain-containing protein; transmembrane protein 225", "tax_id": 10116, "disease": "", "pathway": " (rno:500980)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20979528", "class_list": "", "function": "Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC., [UniProtKB, UniProtKB]; TMEM225 may play an important role in sperm degeneration but not in spermatogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008157 protein phosphatase 1 binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0002079 inner acrosomal membrane;GO:0002081 outer acrosomal membrane", "go_biological_process": "GO:0010923 negative regulation of phosphatase activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6GV27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IE14-1", "uniprot_id": "TM11L_RAT", "mass": 47242.0, "length": 420, "protein_name": "Transmembrane protease serine 11B-like protein", "gene_name": "Tmprss11bnl; Tmprss11b", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tmprss11bnl; Tmprss11b; Hatl5; Tmprss11b", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protease serine 11B-like protein; 3.4.21.-; Airway trypsin-like protease 5; Transmembrane protease serine 11B", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:365265)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "Serine protease., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IE40-1", "uniprot_id": "WFD12_RAT", "mass": 8665.0, "length": 78, "protein_name": "WAP four-disulfide core domain protein 12", "gene_name": "Wfdc12", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Wfdc12", "gene_names_refseq": "", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 12", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "Antibacterial protein. Putative acid-stable proteinase inhibitor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IMG9-1", "uniprot_id": "SMIP8_RAT", "mass": 25065.0, "length": 216, "protein_name": "Sperm microtubule inner protein 8", "gene_name": "Spmip8", "organism": "Rat", "refseq_name": "sperm microtubule inner protein 8", "refseq_ac": "NP_970617", "gene_names_uniprotkb": "Spmip8; Tepp", "gene_names_refseq": "Spmip8; Tepp", "protein_names_uniprotkb": "Sperm microtubule inner protein 8; Testis, prostate and placenta-expressed protein", "protein_names_refseq": "sperm microtubule inner protein 8; testis, prostate and placenta expressed; testis, prostate and placenta-expressed protein; testis/prostate/placenta-expressed protein", "tax_id": 10116, "disease": "", "pathway": " (rno:291850)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14652002", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IMG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IUU3-1", "uniprot_id": "QSOX1_RAT", "mass": 82412.0, "length": 750, "protein_name": "Sulfhydryl oxidase 1", "gene_name": "Qsox1", "organism": "Rat", "refseq_name": "sulfhydryl oxidase 1 isoform A precursor", "refseq_ac": "NP_001103368", "gene_names_uniprotkb": "Qsox1; Qscn6; Sox2", "gene_names_refseq": "Qscn6; Qsox1; Qsox; Sox-2; rSOx", "protein_names_uniprotkb": "Sulfhydryl oxidase 1; 1.8.3.2; FAD-dependent sulfhydryl oxidase-2; Quiescin Q6; SOx-2; rQSOX; rSOx", "protein_names_refseq": "FAD-dependent sulfhydryl oxidase-2; quiescin Q6 sulfhydryl oxidase 1; rQSOX; sulfhydryl oxidase 1 isoform A precursor; sulfhydryl oxidase 1", "tax_id": 10116, "disease": "VACTERL association (Disease Ontology:DOID:14679)", "pathway": " (rno:84491); (R-RNO-114608); (R-RNO-381426); (R-RNO-6798695); (R-RNO-8957275)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "11278790;12354420;12438924;16806532;24888638;25766108;26819240", "class_list": "", "function": "At least two transcripts were detected in brain, suggesting a tissue-specific splicing of its mRNA., [RefSeq, PubMed]; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:11278790). Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (By similarity)., [UniProtKB, PubMed, UniProtKB]; QSOX1 induces VSMC migration and proliferation in vitro and contributes to neointima thickening in balloon-injured rat carotids., [RefSeq, PubMed]; RnQSOX1 gives unprecedented insight into the functional group of the cysteine involved in dithiol/disulfide exchange and provides the framework for analysis of the energetics of electron transfer in the flavin adenine dinucleotide cofactor., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4M2;Q99J80", "ec_number_list": "3.4.21.4;3.6.5.2;1.8.3.2;3.5.4.5;2.3.2.5;2.3.2.13;2.7.1.35;3.4.24.34;3.2.1.17;5.3.4.1;4.1.2.13;3.5.3.1;2.3.1.16;2.3.1.9;2.3.1.155;3.1.1.4;3.1.1.3;1.11.1.27;1.16.3.1;1.11.1.9;1.16.3.4;3.4.23.5;3.3.2.6;3.4.11.4;3.4.21.69;3.4.21.46;1.4.3.22;1.4.3.-;5.4.2.2;1.1.1.42;3.4.24.35;3.4.21.-;3.1.3.48;3.4.22.27;3.4.24.81;3.1.21.-;3.5.1.3;2.4.1.145;2.7.10.2;3.4.19.9;3.6.4.-;1.-.-.-;3.2.1.51;3.5.1.23;3.5.1.-;3.2.1.166;3.6.1.6;3.2.1.18;3.4.18.1;3.4.21.112", "go_molecular_function": "GO:0071949 FAD binding;GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0070062 extracellular exosome", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0006457 protein folding;GO:0016242 negative regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6IUU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IV57-1", "uniprot_id": "RN141_RAT", "mass": 25471.0, "length": 230, "protein_name": "RING finger protein 141", "gene_name": "Rnf141", "organism": "Rat", "refseq_name": "RING finger protein 141", "refseq_ac": "NP_001001800", "gene_names_uniprotkb": "Rnf141; rnf141", "gene_names_refseq": "Rnf141", "protein_names_uniprotkb": "RING finger protein 141", "protein_names_refseq": "RING finger protein 141", "tax_id": 10116, "disease": "", "pathway": " (rno:308900)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in spermatogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6IV57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6J1I7-1", "uniprot_id": "RN166_RAT", "mass": 26064.0, "length": 237, "protein_name": "E3 ubiquitin-protein ligase RNF166", "gene_name": "Rnf166", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF166", "refseq_ac": "NP_001002279", "gene_names_uniprotkb": "Rnf166", "gene_names_refseq": "Rnf166", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF166; 2.3.2.27; RING finger protein 166; RING-type E3 ubiquitin transferase RNF166", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF166; RING-type E3 ubiquitin transferase RNF166", "tax_id": 10116, "disease": "", "pathway": " (rno:365022)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Also plays a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0006914 autophagy;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6J1I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6JWR2-1", "uniprot_id": "S38A7_RAT", "mass": 49846.0, "length": 463, "protein_name": "Sodium-coupled neutral amino acid transporter 7", "gene_name": "Slc38a7", "organism": "Rat", "refseq_name": "sodium-coupled neutral amino acid transporter 7", "refseq_ac": "NP_001003705", "gene_names_uniprotkb": "Slc38a7; Snat7", "gene_names_refseq": "Slc38a7", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 7; Solute carrier family 38 member 7", "protein_names_refseq": "amino acid transporter; putative sodium-coupled neutral amino acid transporter 7; sodium-coupled neutral amino acid transporter 7", "tax_id": 10116, "disease": "", "pathway": " (rno:291840)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015186 L-glutamine transmembrane transporter activity;GO:0015182 L-asparagine transmembrane transporter activity;GO:0140901 L-asparagine:sodium symporter activity;GO:0140902 L-glutamine:sodium symporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006868 glutamine transport;GO:0006814 sodium ion transport;GO:0003333 amino acid transmembrane transport;GO:0006867 asparagine transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6JWR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6MFY5-1", "uniprot_id": "RPA12_RAT", "mass": 13586.0, "length": 123, "protein_name": "DNA-directed RNA polymerase I subunit RPA12", "gene_name": "Polr1h", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerase I subunit RPA12", "refseq_ac": "NP_001159772", "gene_names_uniprotkb": "Polr1h; Znrd1", "gene_names_refseq": "HTEX-6; Polr1h; Tctex6; Znrd1", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA12; DNA-directed RNA polymerase I subunit H; Zinc ribbon domain-containing protein 1", "protein_names_refseq": "DNA-directed RNA polymerase I subunit H; DNA-directed RNA polymerase I subunit RPA12; nuclear RNA polymerase I small specific subunit Rpa12 like; zinc ribbon domain containing 1; zinc ribbon domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361784); (R-RNO-5250924); (R-RNO-73762); (R-RNO-73772); (R-RNO-73863)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "Core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol I active site to monitor transcription fidelity and cleave mis-incorporated 5'-ribonucleotides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005736 RNA polymerase I complex;GO:0005730 nucleolus;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006362 transcription elongation by RNA polymerase I;GO:0006363 termination of RNA polymerase I transcription;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MFY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6MGB6-1", "uniprot_id": "RING1_RAT", "mass": 42661.0, "length": 406, "protein_name": "E3 ubiquitin-protein ligase RING1", "gene_name": "Ring1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RING1", "refseq_ac": "NP_997714", "gene_names_uniprotkb": "Ring1; Rnf1", "gene_names_refseq": "Ring1A; Ring1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RING1; 2.3.2.27; Polycomb complex protein RING1; RING finger protein 1; RING-type E3 ubiquitin transferase RING1", "protein_names_refseq": "E3 ubiquitin-protein ligase RING1; RING-type E3 ubiquitin transferase RING1; polycomb complex protein RING1", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Luo-Schoch-Yamamoto syndrome (Disease Ontology:DOID:0070416); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (rno:309626); (R-RNO-2559580); (R-RNO-3108214); (R-RNO-3899300); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-8939243); (R-RNO-8943724); (R-RNO-8953750)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "15060004;28032293;8662089", "class_list": "", "function": "Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RING1 protein levels were increased at day 3 after spinal cord injury and then decreased gradually., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KMC1;Q63510", "ec_number_list": "2.7.11.24;2.1.1.367;2.1.1.356;2.7.11.1;2.3.2.-;2.3.2.27;1.1.1.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0016604 nuclear body;GO:0000151 ubiquitin ligase complex;GO:0031519 PcG protein complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0009952 anterior/posterior pattern specification;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6MGB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P6S5-1", "uniprot_id": "GET1_RAT", "mass": 19899.0, "length": 174, "protein_name": "Guided entry of tail-anchored proteins factor 1", "gene_name": "Get1", "organism": "Rat", "refseq_name": "guided entry of tail-anchored proteins factor 1", "refseq_ac": "NP_955405", "gene_names_uniprotkb": "Get1; Wrb", "gene_names_refseq": "Get1; Wrb", "protein_names_uniprotkb": "Guided entry of tail-anchored proteins factor 1; Tail-anchored protein insertion receptor WRB; Tryptophan-rich basic protein", "protein_names_refseq": "guided entry of tail-anchored proteins factor 1; tail-anchored protein insertion receptor WRB; tryptophan rich basic protein; tryptophan-rich protein", "tax_id": 10116, "disease": "", "pathway": " (rno:288233)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23041287", "class_list": "", "function": "Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287). Required to ensure correct topology and ER insertion of CAMLG (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0043529 GET complex", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0045048 protein insertion into ER membrane;GO:0050808 synapse organization;GO:0050821 protein stabilization;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P6S5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P9X4-1", "uniprot_id": "TP4A2_RAT", "mass": 19127.0, "length": 167, "protein_name": "Protein tyrosine phosphatase type IVA 2", "gene_name": "Ptp4a2", "organism": "Rat", "refseq_name": "protein tyrosine phosphatase type IVA 2", "refseq_ac": "NP_445927", "gene_names_uniprotkb": "Ptp4a2; Prl2", "gene_names_refseq": "Ptp4a2", "protein_names_uniprotkb": "Protein tyrosine phosphatase type IVA 2; 3.1.3.48; PRL-2; Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2", "protein_names_refseq": "PRL-2; protein tyrosine phosphatase type IVA 2; protein tyrosine phosphatase type IVA, member 2; protein-tyrosine phosphatase of regenerating liver 2", "tax_id": 10116, "disease": "", "pathway": " (rno:85237); (R-RNO-8873719)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9805001", "class_list": "", "function": "Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88765", "ec_number_list": "3.1.3.48;2.7.10.1;3.1.3.16;3.1.3.2;3.1.3.21;3.1.3.18;3.1.3.67;3.1.3.-;3.1.3.27;3.1.3.5;2.5.1.60", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0004725 protein tyrosine phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P9X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P9Z6-1", "uniprot_id": "TACD2_RAT", "mass": 35514.0, "length": 317, "protein_name": "Tumor-associated calcium signal transducer 2", "gene_name": "Tacstd2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tacstd2; Prp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tumor-associated calcium signal transducer 2; Parturition-related protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:494343)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May function as a growth factor receptor., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6K0P4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0050678 regulation of epithelial cell proliferation;GO:1900028 negative regulation of ruffle assembly;GO:1900025 negative regulation of substrate adhesion-dependent cell spreading;GO:2000146 negative regulation of cell motility", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P9Z6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PCT3-1", "uniprot_id": "TPD54_RAT", "mass": 23992.0, "length": 220, "protein_name": "Tumor protein D54", "gene_name": "Tpd52l2", "organism": "Rat", "refseq_name": "tumor protein D54 isoform 2", "refseq_ac": "NP_942039", "gene_names_uniprotkb": "Tpd52l2", "gene_names_refseq": "Tpd52l2", "protein_names_uniprotkb": "Tumor protein D54; Tumor protein D52-like 2", "protein_names_refseq": "tumor protein D52-like 2; tumor protein D54 isoform 2; tumor protein D54", "tax_id": 10116, "disease": "", "pathway": " (rno:296480)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PCT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6QBQ4-1", "uniprot_id": "PLS3_RAT", "mass": 31646.0, "length": 296, "protein_name": "Phospholipid scramblase 3", "gene_name": "Plscr3", "organism": "Rat", "refseq_name": "phospholipid scramblase 3", "refseq_ac": "NP_001012139", "gene_names_uniprotkb": "Plscr3; Pls3", "gene_names_refseq": "Pls3; Plscr3", "protein_names_uniprotkb": "Phospholipid scramblase 3; Ca(2+)-dependent phospholipid scramblase 3; PL scramblase 3", "protein_names_refseq": "PL scramblase 3; ca(2+)-dependent phospholipid scramblase 3; phospholipid scramblase 3", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:360549)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29171872", "class_list": "", "function": "Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:29171872). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (By similarity). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (By similarity). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (By similarity). Regulates cardiolipin de novo biosynthesis and its resynthesis (By similarity)., [UniProtKB, PubMed, UniProtKB]; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PLSCR3, via its C-terminal transmembrane domain, participates in the bidirectional movement of phospholipids within the inner membrane of mitochondria., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V7A3", "ec_number_list": "3.1.-.-;1.6.5.5;2.7.4.6;1.3.1.124", "go_molecular_function": "GO:0032791 lead ion binding;GO:0000287 magnesium ion binding;GO:0017124 SH3 domain binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0090199 regulation of release of cytochrome c from mitochondria;GO:0006915 apoptotic process;GO:0071222 cellular response to lipopolysaccharide;GO:0042593 glucose homeostasis;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6QBQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6RI86-1", "uniprot_id": "TRPA1_RAT", "mass": 128603.0, "length": 1125, "protein_name": "Transient receptor potential cation channel subfamily A member 1", "gene_name": "Trpa1", "organism": "Rat", "refseq_name": "transient receptor potential cation channel subfamily A member 1", "refseq_ac": "NP_997491", "gene_names_uniprotkb": "Trpa1; Anktm1", "gene_names_refseq": "Anktm1; Trpa1; rTRPA1", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; Wasabi receptor", "protein_names_refseq": "Transient Receptor Potential Ankyrin 1; ankyrin-like with transmembrane domains protein 1; transient receptor potential A1 ion channel; transient receptor potential A1; transient receptor potential cation channel subfamily A member 1; wasabi receptor", "tax_id": 10116, "disease": "overactive bladder syndrome (Disease Ontology:DOID:0070355); familial episodic pain syndrome 1 (Disease Ontology:DOID:0111729); asthma (Disease Ontology:DOID:2841); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:312896); (R-RNO-3295583)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12654248;14712238;16110328;18775987;21402443", "class_list": "", "function": "Cellular and molecular target for the pungent action of mustard oils; support an emerging role for TRP channel ANKTM1 as an ionotropic cannabinoid receptor., [RefSeq, PubMed]; Ligand-activated Ca(2+)-permeable, nonselective cation channel (PubMed:14712238, PubMed:18775987). Involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (By similarity). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm, leads to membrane depolarization. Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner. Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation. Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; Results demonstrate that nerve growth factor-induced TRPA1 increase in sensory neurons via p38 activation is necessary for cold hyperalgesia. Erratum:[J Clin Invest. 2010 Jan;120(1):394], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1LRH9", "ec_number_list": "2.7.11.1;1.8.-.-", "go_molecular_function": "GO:0097604 temperature-gated cation channel activity;GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0016324 apical plasma membrane;GO:0032421 stereocilium bundle", "go_biological_process": "GO:0070417 cellular response to cold;GO:0071240 cellular response to food;GO:0007166 cell surface receptor signaling pathway;GO:0009409 response to cold;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6RI86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6SA80-1", "uniprot_id": "RND3_RAT", "mass": 27368.0, "length": 244, "protein_name": "Rho-related GTP-binding protein RhoE", "gene_name": "Rnd3", "organism": "Rat", "refseq_name": "rho-related GTP-binding protein RhoE", "refseq_ac": "NP_001007642", "gene_names_uniprotkb": "Rnd3; Arhe; Rhoe", "gene_names_refseq": "Arhe; RHOE; Rnd3", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoE; 3.6.5.2; Rho family GTPase 3; Rnd3", "protein_names_refseq": "ras homolog gene family, member E; rho-related GTP-binding protein RhoE", "tax_id": 10116, "disease": "ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (rno:295588); (R-RNO-9696264)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16311049;23762244;32705255;38724005", "class_list": "", "function": "BDNF can regulate formation of functional synapses by increasing the expression of the RhoA inhibitors, Par6C and Rnd3. Publication Status: Online-Only, [RefSeq, PubMed]; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins., [UniProtKB]; Ingenuity pathway analysis of differentially expressed genes involved in signaling pathways and molecular networks in RhoE geneedited cardiomyocytes., [RefSeq, PubMed]; Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence., [RefSeq, PubMed]; The Rnd3 mRNA levels increased significantly after gestation in rat myometria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.10.1;2.7.11.1;3.1.3.48;3.6.5.5;3.6.1.5;2.7.3.2;3.6.1.-;2.7.11.39;3.6.4.13;3.6.5.4;3.4.17.22", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6SA80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q70EX6-1", "uniprot_id": "SOAT_RAT", "mass": 40310.0, "length": 370, "protein_name": "Sodium-dependent organic anion transporter", "gene_name": "Slc10a6", "organism": "Rat", "refseq_name": "sodium-dependent organic anion transporter", "refseq_ac": "NP_932166", "gene_names_uniprotkb": "Slc10a6; Soat", "gene_names_refseq": "Slc10a6; Soat", "protein_names_uniprotkb": "Sodium-dependent organic anion transporter; SLC10A6; Soat; Solute carrier family 10 member 6", "protein_names_refseq": "sodium-dependent organic anion transporter; solute carrier family 10 (sodium/bile acid cotransporter family), member 6; solute carrier family 10 (sodium/bile acid cotransporter), member 6", "tax_id": 10116, "disease": "", "pathway": " (rno:289459); (R-RNO-9958517)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15020217", "class_list": "", "function": "Cloning and analysis of transport function of Soat., [RefSeq, PubMed]; Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:15020217). Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids (By similarity). May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (By similarity). May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium (By similarity). Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0043251 sodium-dependent organic anion transport;GO:0015721 bile acid and bile salt transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q70EX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M0E7-1", "uniprot_id": "RM14_RAT", "mass": 15913.0, "length": 145, "protein_name": "Large ribosomal subunit protein uL14m", "gene_name": "Mrpl14", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL14m precursor", "refseq_ac": "NP_001100360", "gene_names_uniprotkb": "Mrpl14; Rpml32", "gene_names_refseq": "L14mt; L32mt; MRP-L14; MRP-L32; Mrpl14", "protein_names_uniprotkb": "Large ribosomal subunit protein uL14m; 39S ribosomal protein L14, mitochondrial; 39S ribosomal protein L32, mitochondrial; L14mt; L32mt; MRP-L14; MRP-L32", "protein_names_refseq": "39S ribosomal protein L14, mitochondrial; 39S ribosomal protein L32, mitochondrial; large ribosomal subunit protein uL14m precursor; large ribosomal subunit protein uL14m", "tax_id": 10116, "disease": "", "pathway": " (rno:301250); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "29393594;9857009", "class_list": "", "function": "May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7M0E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M734-1", "uniprot_id": "OTOP1_RAT", "mass": 65929.0, "length": 600, "protein_name": "Proton channel OTOP1", "gene_name": "Otop1", "organism": "Rat", "refseq_name": "proton channel OTOP1", "refseq_ac": "NP_852098", "gene_names_uniprotkb": "Otop1", "gene_names_refseq": "Otop1", "protein_names_uniprotkb": "Proton channel OTOP1; Otopetrin-1", "protein_names_refseq": "proton channel OTOP1", "tax_id": 10116, "disease": "", "pathway": " (rno:305427)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12651873", "class_list": "", "function": "Proton-selective ion channel. Biphasically modulated by acid and alkali, mediating proton influx and efflux in response to extracellular acid and base stimulation, respectively. Sour taste receptor, which carries inward currents in response to extracellular acidification. Sensor for ammonium chloride (NH(4)Cl) in taste receptor cells. NH(4)Cl acts by increasing the intracellular pH, thereby generating a driving force for proton entry through OTOP1 channel. Might also participate in alkaline sensation. Plays a role in the regulation of Ca(2+) flux in response to purigenic (ATP, ADP and UDP) stimuli, leading to increase in cytosolic Ca(2+) due to influx of extracellular calcium. May play this role by inhibiting P2Y purinoceptor-mediated Ca(2+) release in a Ca(2+)-dependent manner and promote an influx of Ca(2+) in response to ATP. Through this mechanism and possibly others, plays a role in the formation and function of calcium carbonate-based structures in the vestibular system of the inner ear, called otoconia, that sense gravity and linear acceleration. In obesity, may attenuate adipose tissue inflammation, through the negative regulation of IFNG signaling, hence may play an adaptive role in the maintainance of metabolic homeostasis. Following alkali activation, may also be permeable Na(+), K(+), Cs(+) and Li(+)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0015252 proton channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005902 microvillus", "go_biological_process": "GO:0009590 detection of gravity;GO:0032869 cellular response to insulin stimulus;GO:0042472 inner ear morphogenesis;GO:0060336 negative regulation of type II interferon-mediated signaling pathway;GO:0032475 otolith formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7M734-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNB2-1", "uniprot_id": "TNNT1_RAT", "mass": 31215.0, "length": 261, "protein_name": "Troponin T, slow skeletal muscle", "gene_name": "Tnnt1", "organism": "Rat", "refseq_name": "troponin T, slow skeletal muscle isoform 2", "refseq_ac": "NP_001264189", "gene_names_uniprotkb": "Tnnt1; Fang2", "gene_names_refseq": "Fang2; Tnnt1; sTnT; tnTs", "protein_names_uniprotkb": "Troponin T, slow skeletal muscle; Slow skeletal muscle troponin T; TnTs; sTnT", "protein_names_refseq": "slow skeletal muscle troponin T; troponin T type 1 (skeletal, slow); troponin T, slow skeletal muscle isoform 2; troponin T, slow skeletal muscle; troponin T1, skeletal, slow", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); nemaline myopathy 5B (Disease Ontology:DOID:0081374); nemaline myopathy 5C (Disease Ontology:DOID:0081375); nemaline myopathy 5A (Disease Ontology:DOID:0110936); nemaline myopathy (Disease Ontology:DOID:3191)", "pathway": " (rno:171409); (R-RNO-390522)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15788488;22673903", "class_list": "", "function": "Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNA9;Q7TNB0;Q7TNB1;Q923S7", "ec_number_list": "", "go_molecular_function": "GO:0031014 troponin T binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0014883 transition between fast and slow fiber;GO:0045214 sarcomere organization;GO:0031444 slow-twitch skeletal muscle fiber contraction;GO:0045932 negative regulation of muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TNB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNZ5-1", "uniprot_id": "REBL1_RAT", "mass": 20749.0, "length": 183, "protein_name": "GTPase RhebL1", "gene_name": "Rhebl1", "organism": "Rat", "refseq_name": "GTPase RhebL1", "refseq_ac": "NP_877977", "gene_names_uniprotkb": "Rhebl1", "gene_names_refseq": "Rhebl1", "protein_names_uniprotkb": "GTPase RhebL1; 3.6.5.-; Ras homolog enriched in brain-like protein 1; Rheb-like protein 1", "protein_names_refseq": "GTPase RhebL1; Ras homolog enriched in brain like 1; ras homolog enriched in brain-like protein 1; rheb-like protein 1", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); tuberous sclerosis (Disease Ontology:DOID:13515); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:359959)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16328882", "class_list": "", "function": "Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0016020 membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0007264 small GTPase-mediated signal transduction;GO:0031929 TOR signaling;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TNZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPA5-1", "uniprot_id": "SPA11_RAT", "mass": 47024.0, "length": 422, "protein_name": "Serpin A11", "gene_name": "Serpina11", "organism": "Rat", "refseq_name": "serpin A11 isoform 1 precursor", "refseq_ac": "NP_001008776", "gene_names_uniprotkb": "Serpina11; Ab1-046", "gene_names_refseq": "Ab1-046; Serpina11", "protein_names_uniprotkb": "Serpin A11; Liver regeneration-related protein LRRG023", "protein_names_refseq": "liver regeneration-related protein LRRG023; serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11; serpin A11 isoform 1 precursor; serpin A11; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11; serpin peptidase inhibitor, clade A, member 11", "tax_id": 10116, "disease": "alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (rno:362774)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q2M2R9", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TPA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQ16-1", "uniprot_id": "QCR8_RAT", "mass": 9849.0, "length": 82, "protein_name": "Cytochrome b-c1 complex subunit 8", "gene_name": "Uqcrq", "organism": "Rat", "refseq_name": "cytochrome b-c1 complex subunit 8", "refseq_ac": "NP_001020305", "gene_names_uniprotkb": "Uqcrq; Qpc", "gene_names_refseq": "Qpc; Uqcrq", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 8; Complex III subunit 8; Complex III subunit VIII; Low molecular mass ubiquinone-binding protein; Ubiquinol-cytochrome c reductase complex 9.5 kDa protein; Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C", "protein_names_refseq": "complex III subunit 8; complex III subunit VIII; cytochrome b-c1 complex subunit 8; low molecular mass ubiquinone-binding protein; ubiquinol-cytochrome c reductase complex 9.5 kDa protein; ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C", "tax_id": 10116, "disease": "mitochondrial complex III deficiency nuclear type 4 (Disease Ontology:DOID:0080113)", "pathway": " (rno:497902); (R-RNO-611105); (R-RNO-9837999); (R-RNO-9865881)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "26446791;29393594;38843836", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0021766 hippocampus development;GO:0021680 cerebellar Purkinje cell layer development;GO:0021860 pyramidal neuron development;GO:0021854 hypothalamus development;GO:0021539 subthalamus development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TQ16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQ79-1", "uniprot_id": "T170B_RAT", "mass": 14416.0, "length": 132, "protein_name": "Transmembrane protein 170B", "gene_name": "Tmem170b", "organism": "Rat", "refseq_name": "transmembrane protein 170B", "refseq_ac": "NP_001008774", "gene_names_uniprotkb": "Tmem170b; Ac1258", "gene_names_refseq": "Tmem170b", "protein_names_uniprotkb": "Transmembrane protein 170B; Liver regeneration-related protein LRRG102", "protein_names_refseq": "Ac1258; liver regeneration-related protein LRRG102; transmembrane protein 170B", "tax_id": 10116, "disease": "", "pathway": " (rno:361230)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TQ79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W92-1", "uniprot_id": "VAC14_RAT", "mass": 88068.0, "length": 783, "protein_name": "Protein VAC14 homolog", "gene_name": "Vac14", "organism": "Rat", "refseq_name": "protein VAC14 homolog", "refseq_ac": "NP_808791", "gene_names_uniprotkb": "Vac14", "gene_names_refseq": "Vac14", "protein_names_uniprotkb": "Protein VAC14 homolog", "protein_names_refseq": "Vac14 homolog; Vac14, PIKFYVE complex component; protein VAC14 homolog; vacuole 14 protein", "tax_id": 10116, "disease": "striatonigral degeneration (Disease Ontology:DOID:4751)", "pathway": " (rno:307842); (R-RNO-1660514); (R-RNO-1660516); (R-RNO-1660517)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "12719380;17161399", "class_list": "", "function": "Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0010008 endosome membrane;GO:0098830 presynaptic endosome;GO:0070772 PAS complex;GO:0012505 endomembrane system", "go_biological_process": "GO:0006661 phosphatidylinositol biosynthetic process;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization;GO:1903100 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80W92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YE2-1", "uniprot_id": "T53I1_RAT", "mass": 26976.0, "length": 239, "protein_name": "Tumor protein p53-inducible nuclear protein 1", "gene_name": "Trp53inp1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Trp53inp1; Sip", "gene_names_refseq": "", "protein_names_uniprotkb": "Tumor protein p53-inducible nuclear protein 1; Stress-induced protein; TEAP; Thymus-expressed acidic protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:297822)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15254349", "class_list": "", "function": "Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0016605 PML body", "go_biological_process": "GO:1904761 negative regulation of myofibroblast differentiation;GO:0000045 autophagosome assembly;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80YE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZF7-1", "uniprot_id": "RDH10_RAT", "mass": 38061.0, "length": 341, "protein_name": "Retinol dehydrogenase 10", "gene_name": "Rdh10", "organism": "Rat", "refseq_name": "retinol dehydrogenase 10", "refseq_ac": "NP_852143", "gene_names_uniprotkb": "Rdh10", "gene_names_refseq": "Rdh10", "protein_names_uniprotkb": "Retinol dehydrogenase 10; 1.1.1.300", "protein_names_refseq": "retinol dehydrogenase 10 (all-trans); retinol dehydrogenase 10", "tax_id": 10116, "disease": "", "pathway": " (rno:353252); (R-RNO-2453902); (R-RNO-5365859)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15505029", "class_list": "", "function": "Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.300;1.1.1.184;1.1.1.122;1.1.1.30;1.1.1.104;1.1.1.-;1.1.1.21;1.1.1.372;1.1.1.54;1.1.1.105;1.1.1.209;1.1.1.53", "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060431 primary lung bud formation;GO:0043584 nose development;GO:0001701 in utero embryonic development;GO:0042572 retinol metabolic process;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80ZF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810F5-1", "uniprot_id": "T184C_RAT", "mass": 57917.0, "length": 503, "protein_name": "Transmembrane protein 184C", "gene_name": "Tmem184c", "organism": "Rat", "refseq_name": "transmembrane protein 184C", "refseq_ac": "NP_847900", "gene_names_uniprotkb": "Tmem184c; Tmem34", "gene_names_refseq": "Tmem184c; Tmem34", "protein_names_uniprotkb": "Transmembrane protein 184C; Transmembrane protein 34", "protein_names_refseq": "DNA sequence AY228474; transmembrane protein 184C; transmembrane protein 34", "tax_id": 10116, "disease": "", "pathway": " (rno:291946)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Possible tumor suppressor which may play a role in cell growth., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q810F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q811Q1-1", "uniprot_id": "SMUG1_RAT", "mass": 30562.0, "length": 278, "protein_name": "Single-strand selective monofunctional uracil-DNA glycosylase", "gene_name": "Smug1", "organism": "Rat", "refseq_name": "single-strand selective monofunctional uracil-DNA glycosylase", "refseq_ac": "NP_808795", "gene_names_uniprotkb": "Smug1", "gene_names_refseq": "Smug1", "protein_names_uniprotkb": "Single-strand selective monofunctional uracil-DNA glycosylase; 3.2.2.-", "protein_names_refseq": "single-strand selective monofunctional uracil-DNA glycosylase", "tax_id": 10116, "disease": "", "pathway": " (rno:315344); (R-RNO-110329); (R-RNO-110357)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "12718543", "class_list": "", "function": "Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This enzyme has a role in repair of 5-formyluracil and other oxidized and deaminated base lesions., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.11.2;3.1.21.-;3.2.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0019104 DNA N-glycosylase activity;GO:0004844 uracil DNA N-glycosylase activity;GO:0017065 single-strand selective uracil DNA N-glycosylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center", "go_biological_process": "GO:0006281 DNA repair;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q811Q1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFS3-1", "uniprot_id": "REL3_RAT", "mass": 14922.0, "length": 140, "protein_name": "Relaxin-3", "gene_name": "Rln3", "organism": "Rat", "refseq_name": "relaxin-3 precursor", "refseq_ac": "NP_733767", "gene_names_uniprotkb": "Rln3; Insl7", "gene_names_refseq": "Insl7; Rln3", "protein_names_uniprotkb": "Relaxin-3; Insulin-like peptide 7; Insulin-like peptide INSL7; Prorelaxin R3", "protein_names_refseq": "insulin-like 7; insulin-like peptide 7; insulin-like peptide INSL7; prorelaxin R3; relaxin-3 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:266997); (R-RNO-418594); (R-RNO-444821)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12354304;12686464;14522968;15155573;15845093;30412752;31897576;32532885;34214757;38970242", "class_list": "", "function": "Acute Stress Affects the Relaxin/Insulin-Like Family Peptide Receptor 3 mRNA Expression in Brain of Pubertal Male Wistar Rats., [RefSeq, PubMed]; Effects of chronic silencing of relaxin-3 production in nucleus incertus neurons on food intake, body weight, anxiety-like behaviour and limbic brain activity in female rats., [RefSeq, PubMed]; Endurance exercise improves avoidance learning and spatial memory, through changes in genes of GABA and relaxin-3, in rats., [RefSeq, PubMed]; GPCR135 (SALPR) is the receptor for relaxin-3 Rln3 is the only member of the insulin/relaxin superfamily that can activate GPCR135. In situ hybridization showed that relaxin-3 mRNA is predominantly expressed in the dorsomedial ventral tegmental nucleus of, [RefSeq, PubMed]; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity)., [UniProtKB]; RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior., [RefSeq, PubMed]; Relaxin 3 produced in the nucleus incertus is released from nerve endings and is involved in the regulation of the stress response., [RefSeq, PubMed]; Relaxin regulates fibroblast proliferation, differentiation, and collagen deposition and may have therapeutic potential in diseased states characterized by cardiac fibrosis., [RefSeq, PubMed]; Study shows that relaxin-3 regulates corticotropin-releasing factor gene expression in cultured rat hypothalamic 4B cells. Results suggest that the action of relaxin-3 in cultured hypothalamic 4B cells may be regulated through both RXFP1 and RXFP3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BFS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CG07-1", "uniprot_id": "WRIP1_RAT", "mass": 71934.0, "length": 660, "protein_name": "ATPase WRNIP1", "gene_name": "Wrnip1", "organism": "Rat", "refseq_name": "ATPase WRNIP1", "refseq_ac": "NP_758835", "gene_names_uniprotkb": "Wrnip1; Wrnip", "gene_names_refseq": "Whip; Wrnip1; Wrnip", "protein_names_uniprotkb": "ATPase WRNIP1; 3.6.1.-; Werner helicase-interacting protein 1", "protein_names_refseq": "ATPase WRNIP1; Werner helicase interacting protein 1; Werner syndrome homolog interacting protein; werner helicase-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:282835)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.1.4.-;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0045087 innate immune response;GO:0000731 DNA synthesis involved in DNA repair;GO:0006261 DNA-templated DNA replication;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CG07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIX1-1", "uniprot_id": "RIMS4_RAT", "mass": 29271.0, "length": 269, "protein_name": "Regulating synaptic membrane exocytosis protein 4", "gene_name": "Rims4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rims4", "gene_names_refseq": "", "protein_names_uniprotkb": "Regulating synaptic membrane exocytosis protein 4; RIM 4; RIM4 gamma; Rab3-interacting molecule 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:266976)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12620390", "class_list": "", "function": "Regulates synaptic membrane exocytosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0045202 synapse;GO:0097060 synaptic membrane;GO:0098793 presynapse", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0007269 neurotransmitter secretion;GO:0006887 exocytosis;GO:0050807 regulation of synapse organization;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CIX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3K1-2", "uniprot_id": "USH2A_RAT", "mass": 562986.0, "length": 5125, "protein_name": "Usherin", "gene_name": "Ush2a", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ush2a", "gene_names_refseq": "", "protein_names_uniprotkb": "Usherin; Usher syndrome type IIa protein homolog; Usher syndrome type-2A protein homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "Usher syndrome (Disease Ontology:DOID:0050439); nonsyndromic deafness (Disease Ontology:DOID:0050563); retinitis pigmentosa 39 (Disease Ontology:DOID:0110360); Usher syndrome type 2 (Disease Ontology:DOID:0110827); Usher syndrome type 2A (Disease Ontology:DOID:0110838); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "12160733;16301216", "class_list": "", "function": "Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 21, "predicted_n_glycosites": 19, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "F1M2F9", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0043195 terminal bouton;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0048496 maintenance of animal organ identity;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K3K1-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4G9-1", "uniprot_id": "PODO_RAT", "mass": 42387.0, "length": 383, "protein_name": "Podocin", "gene_name": "Nphs2", "organism": "Rat", "refseq_name": "podocin isoform X1", "refseq_ac": "XP_038946219", "gene_names_uniprotkb": "Nphs2", "gene_names_refseq": "Nphs2; podocin", "protein_names_uniprotkb": "Podocin", "protein_names_refseq": "podocin isoform X1", "tax_id": 10116, "disease": "nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); membranous glomerulonephritis (Disease Ontology:DOID:10976); nephrotic syndrome (Disease Ontology:DOID:1184); proteinuria (Disease Ontology:DOID:576)", "pathway": " (rno:170672); (R-RNO-373753)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12506137;17537921", "class_list": "", "function": "Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G090;Q80WP2;Q8CJE4;Q920E2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0045121 membrane raft;GO:0071944 cell periphery;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0010467 gene expression;GO:0072249 metanephric podocyte development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K4G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K586-1", "uniprot_id": "RANT_RAT", "mass": 24451.0, "length": 216, "protein_name": "GTP-binding nuclear protein Ran, testis-specific isoform", "gene_name": "Rasl2-9", "organism": "Rat", "refseq_name": "GTP-binding nuclear protein Ran, testis-specific isoform", "refseq_ac": "NP_001160147", "gene_names_uniprotkb": "Rasl2-9", "gene_names_refseq": "Rasl2-9", "protein_names_uniprotkb": "GTP-binding nuclear protein Ran, testis-specific isoform; 3.6.5.-", "protein_names_refseq": "GTP-ase Ran; GTP-binding nuclear protein Ran, testis-specific isoform", "tax_id": 10116, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:751812)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12211070", "class_list": "", "function": "GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K586-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R415-1", "uniprot_id": "PKR2_RAT", "mass": 43603.0, "length": 383, "protein_name": "Prokineticin receptor 2", "gene_name": "Prokr2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Prokr2; Gpr73l1; Pkr2", "gene_names_refseq": "", "protein_names_uniprotkb": "Prokineticin receptor 2; G protein-coupled receptor 73-like 1; G protein-coupled receptor I5E; PK-R2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:192649); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "12054613", "class_list": "", "function": "Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004983 neuropeptide Y receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R415-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R416-1", "uniprot_id": "PKR1_RAT", "mass": 44507.0, "length": 393, "protein_name": "Prokineticin receptor 1", "gene_name": "Prokr1", "organism": "Rat", "refseq_name": "prokineticin receptor 1", "refseq_ac": "NP_620433", "gene_names_uniprotkb": "Prokr1; Gpr73; Pkr1", "gene_names_refseq": "Gpr73; Prokr1", "protein_names_uniprotkb": "Prokineticin receptor 1; G protein-coupled receptor 73; G protein-coupled receptor ZAQ; PK-R1", "protein_names_refseq": "G protein-coupled receptor 73; G protein-coupled receptor ZAQ; PK-R1; prokineticin receptor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:192648); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12054613;15978772;25153663;26490969;31744994", "class_list": "", "function": "Given one of the cognate receptors of prokineticin 2, prokineticin receptor 1 (PKR1) was significantly upregulated in orchitis as discussed in the current study, it is very likely that PK2/PKR1 signaling contribute to the development of inflammation-related testicular diseases., [RefSeq, PubMed]; Prokineticin 2 overexpression induces spermatocyte apoptosis in varicocele in rats., [RefSeq, PubMed]; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity)., [UniProtKB]; These results indicate that Prokr1 is sensitive to nutritional status in male rats and that this sensitivity has already been established by the early neonatal period., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4AEG4", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004983 neuropeptide Y receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0032870 cellular response to hormone stimulus;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R416-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R424-1", "uniprot_id": "STABP_RAT", "mass": 48512.0, "length": 424, "protein_name": "STAM-binding protein", "gene_name": "Stambp", "organism": "Rat", "refseq_name": "STAM-binding protein", "refseq_ac": "NP_612540", "gene_names_uniprotkb": "Stambp; Amsh", "gene_names_refseq": "Amsh; Stambp", "protein_names_uniprotkb": "STAM-binding protein; 3.4.19.-; Associated molecule with the SH3 domain of STAM", "protein_names_refseq": "STAM-binding protein; associated molecule with the SH3 domain of STAM", "tax_id": 10116, "disease": "", "pathway": " (rno:171565); (R-RNO-5689901)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "37591460", "class_list": "", "function": "Modulatory role of alpha-MSH in hippocampal-dependent memory impairment, synaptic plasticity changes, oxidative stress, and astrocyte reactivity induced by short-term high-fat diet intake., [RefSeq, PubMed]; Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.-", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0061578 K63-linked deubiquitinase activity;GO:0101005 deubiquitinase activity;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0070536 protein K63-linked deubiquitination;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R424-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VBV2-1", "uniprot_id": "SG11A_RAT", "mass": 7799.0, "length": 68, "protein_name": "Sperm-associated antigen 11A", "gene_name": "Spag11a", "organism": "Rat", "refseq_name": "sperm-associated antigen 11A precursor", "refseq_ac": "NP_659555", "gene_names_uniprotkb": "Spag11a; Bin1b; Ep2; Spag11", "gene_names_refseq": "Bin1b; Spag11a; Spag11b; Spag11", "protein_names_uniprotkb": "Sperm-associated antigen 11A; Antimicrobial-like protein Bin-1b; EP2 protein", "protein_names_refseq": "EP2 protein; anti-microbial-like protein BIN-1B; antimicrobial-like protein Bin-1b; sperm associated antigen 11B; sperm-associated antigen 11A precursor; sperm-associated antigen 11", "tax_id": 10116, "disease": "", "pathway": " (rno:246305)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11230693;15122269;20826730;24777385;31691005;35438340", "class_list": "", "function": "Ablation of the sperm-associated antigen 11A (SPAG11A) protein by active immunization promotes epididymal oncogenesis in the rat., [RefSeq, PubMed]; Androgen receptor and NF-kappaB proteins bind to the upstream regulatory sequences of the rat Spag11e gene to regulate expression., [RefSeq, PubMed]; Data show that Bin1b can bind to the sperm head in different regions of the epididymis with varied binding patterns, and can induce progressive sperm motility in immotile immature sperm., [RefSeq, PubMed]; Evidence suggests SPAG11E expression in epididymis has a role in sperm motility: SPAG11E expression is down-regulated in epididymitis (associated with decreased sperm motility); exogenous SPAG11E corrects sperm motility, [RefSeq, PubMed]; Has antimicrobial activity against E.coli (PubMed:11230693). Plays a role in the defense response in the male reproductive tract, contributing to sperm maturation, storage and protection (PubMed:11230693)., [UniProtKB, PubMed]; SiRNA-mediated knockdown of sperm-associated antigen 11a (Spag11a) mRNA in epididymal primary epithelial cells affects proliferation: a transcriptome analyses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VBV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VD52-1", "uniprot_id": "PLPP_RAT", "mass": 33115.0, "length": 309, "protein_name": "Chronophin", "gene_name": "Pdxp", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pdxp; Cin; Plpp; Plp; Rbp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Chronophin; 3.1.3.16; 3.1.3.74; PLP phosphatase; Pyridoxal phosphate phosphatase; Reg I-binding protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:727679)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.53;3.1.3.52;3.1.3.67;3.1.3.-;3.1.3.1;3.9.1.1;3.1.3.27;2.7.11.22;3.1.3.74", "go_molecular_function": "GO:0033883 pyridoxal phosphatase activity;GO:0000287 magnesium ion binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0016311 dephosphorylation;GO:0032361 pyridoxal phosphate catabolic process;GO:0006470 protein dephosphorylation;GO:0007088 regulation of mitotic nuclear division;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VD52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VD89-1", "uniprot_id": "RNS1G_RAT", "mass": 16935.0, "length": 152, "protein_name": "Ribonuclease pancreatic gamma-type", "gene_name": "", "organism": "Rat", "refseq_name": "ribonuclease pancreatic gamma-type precursor", "refseq_ac": "NP_001020287", "gene_names_uniprotkb": "", "gene_names_refseq": "RGD1565230; Rnase1l2", "protein_names_uniprotkb": "Ribonuclease pancreatic gamma-type; 4.6.1.18; RNase 1 gamma", "protein_names_refseq": "RNase 1 gamma; pancreatic ribonuclease gamma; ribonuclease pancreatic gamma-type precursor; ribonuclease pancreatic gamma-type; ribonuclease, RNase A family, 1-like 2 (pancreatic)", "tax_id": 10116, "disease": "", "pathway": " (rno:305844)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12399926", "class_list": "", "function": "Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004540 RNA nuclease activity;GO:0004522 ribonuclease A activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VD89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHI8-1", "uniprot_id": "SEC20_RAT", "mass": 26170.0, "length": 228, "protein_name": "Vesicle transport protein SEC20", "gene_name": "Bnip1", "organism": "Rat", "refseq_name": "vesicle transport protein SEC20", "refseq_ac": "NP_543173", "gene_names_uniprotkb": "Bnip1; Sec20l", "gene_names_refseq": "Bnip1l1; Bnip1", "protein_names_uniprotkb": "Vesicle transport protein SEC20", "protein_names_refseq": "BCL2/adenovirus E1B 19kDa-interacting protein 1; BCL2/adenovirus E1B interacting protein 1-like 1; vesicle transport protein SEC20", "tax_id": 10116, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (rno:140932); (R-RNO-6811434)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Also plays a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0048763 calcium-induced calcium release activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0015031 protein transport;GO:0042594 response to starvation;GO:0006915 apoptotic process;GO:0014823 response to activity;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VHI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHM6-1", "uniprot_id": "RPC9_RAT", "mass": 16627.0, "length": 148, "protein_name": "DNA-directed RNA polymerase III subunit RPC9", "gene_name": "Crcp", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerase III subunit RPC9", "refseq_ac": "NP_446122", "gene_names_uniprotkb": "Crcp", "gene_names_refseq": "Cgrp-rcp; Crcp", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC9; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; Calcitonin gene-related peptide-receptor component protein; RNA polymerase III subunit C9", "protein_names_refseq": "CGRP-receptor component protein; CGRPRCP; DNA-directed RNA polymerase III subunit RPC9; RNA polymerase III subunit C9; calcitonin gene-related peptide-receptor component protein", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (rno:114205); (R-RNO-76061); (R-RNO-76066); (R-RNO-76071)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "12015206;22074408;23958278;24321404;25687546", "class_list": "", "function": "Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; CGRP receptor is widely distributed in the trigeminovascular system and other pain- processing brain structures., [RefSeq, PubMed]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Early maternal deprivation leads to reduced levels of calcitonin gene related peptide in the hippocampus., [RefSeq, PubMed]; The alleviating effect of non-excitatory electrical stimulation in myocardial infarction may be associated with modulation of endogenous CGRP expression in the myocardium., [RefSeq, PubMed]; These data suggest that CGRP is expressed in C-fibers and may act on A-fibers, rodent mast cells, and vascular smooth muscle cells that express the CGRP receptor., [RefSeq, PubMed]; This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z0W9", "ec_number_list": "", "go_molecular_function": "GO:0000166 nucleotide binding;GO:0001635 calcitonin gene-related peptide receptor activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VHM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XS8-1", "uniprot_id": "ST17B_RAT", "mass": 42133.0, "length": 371, "protein_name": "Serine/threonine-protein kinase 17B", "gene_name": "Stk17b", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase 17B", "refseq_ac": "NP_596883", "gene_names_uniprotkb": "Stk17b; Drak2", "gene_names_refseq": "Drak2; Stk17b", "protein_names_uniprotkb": "Serine/threonine-protein kinase 17B; 2.7.11.1; DAP kinase-related apoptosis-inducing protein kinase 2", "protein_names_refseq": "DAP kinase-related apoptosis-inducing protein kinase 2; death-associated protein kinase-related 2; serine/threonine kinase 17b (apoptosis-inducing); serine/threonine-protein kinase 17B", "tax_id": 10116, "disease": "", "pathway": " (rno:170904)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11481038;12966074;18084041", "class_list": "", "function": "Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains., [UniProtKB, PubMed, PubMed]; These results suggest that phosphorylation of Ser350 plays an essential role in regulating translocation of DRAK2 to the nucleus from the cytoplasm, possibly by affecting the activity of the nuclear localization signal., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91XS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923K1-1", "uniprot_id": "TS1R3_RAT", "mass": 94846.0, "length": 858, "protein_name": "Taste receptor type 1 member 3", "gene_name": "Tas1r3", "organism": "Rat", "refseq_name": "taste receptor type 1 member 3 precursor", "refseq_ac": "NP_570831", "gene_names_uniprotkb": "Tas1r3; T1r3; Tr3", "gene_names_refseq": "T1r3; Tas1r3", "protein_names_uniprotkb": "Taste receptor type 1 member 3; Sweet taste receptor T1R3", "protein_names_refseq": "G-protein coupled receptor (GPCR); sweet taste receptor T1R3; taste receptor type 1 member 3 precursor; taste receptor, type 1, member 3", "tax_id": 10116, "disease": "", "pathway": " (rno:170634); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11509186;11917125;24898279;26096555;28474538;28782537;31655082", "class_list": "", "function": "Low concentration of endogenous GC is necessary and sufficient for induction of T1R3 expression. Higher concentrations may inhibit such induction. This inhibitory effect may be due, at least in part, to a direct action of GC on taste cells., [RefSeq, PubMed]; Maternal high-fat diet during gestation and lactation increases conditioned aversion threshold for sucrose and alters sweet taste receptors expression in taste buds in rat offspring., [RefSeq, PubMed]; Our research indicates that the T1R1/T1R3 receptor is an anti-inflammatory receptor for infiltrating granulocytes after spinal cord injury, [RefSeq, PubMed]; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity)., [UniProtKB]; Sweet taste molecules of T1R2, T1R3, alpha-gustducin and TRPM5 in ileum were dramatically higher than those in duodenum (P<0.01 for each)., [RefSeq, PubMed]; T1R3 is expressed mainly in beta-cells and the expression levels are different depending upon the nutritional and metabolic conditions., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033041 sweet taste receptor activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:1903767 sweet taste receptor complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0038037 G protein-coupled receptor dimeric complex", "go_biological_process": "GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste;GO:0050916 sensory perception of sweet taste;GO:0050917 sensory perception of umami taste", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q923K1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923X8-1", "uniprot_id": "TAA7B_RAT", "mass": 40291.0, "length": 358, "protein_name": "Trace amine-associated receptor 7b", "gene_name": "Taar7b", "organism": "Rat", "refseq_name": "trace amine-associated receptor 7b", "refseq_ac": "NP_783176", "gene_names_uniprotkb": "Taar7b; Ta12; Tar12v; Trar12", "gene_names_refseq": "TA12; Taar7b", "protein_names_uniprotkb": "Trace amine-associated receptor 7b; TaR-12; TaR-7b; Trace amine receptor 12; Trace amine receptor 7b", "protein_names_refseq": "taR-12; taR-7b; trace amine receptor 12; trace amine receptor 7b; trace amine-associated receptor 7b", "tax_id": 10116, "disease": "", "pathway": " (rno:294126)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11459929;15718104;17556730;22545963", "class_list": "", "function": "Expression of Taar family members is limited to specific tissue subpopulations and developmental stages in mouse., [RefSeq, PubMed]; Olfactory receptor specific for N,N-dimethylalkylamines trace amines, such as N,N-dimethylcyclohexylamine (PubMed:22545963). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:22545963). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5QD22", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q923X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923Y1-1", "uniprot_id": "TAA7G_RAT", "mass": 39963.0, "length": 358, "protein_name": "Trace amine-associated receptor 7g", "gene_name": "Taar7g", "organism": "Rat", "refseq_name": "trace amine-associated receptor 7g", "refseq_ac": "NP_783178", "gene_names_uniprotkb": "Taar7g; Ta9; Tar9; Trar9", "gene_names_refseq": "Ta9; Taar7g", "protein_names_uniprotkb": "Trace amine-associated receptor 7g; TaR-7g; TaR-9; Trace amine receptor 7g; Trace amine receptor 9", "protein_names_refseq": "taR-7g; taR-9; trace amine receptor 7g; trace amine receptor 9; trace amine-associated receptor 7g", "tax_id": 10116, "disease": "", "pathway": " (rno:294131)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11459929;17556730", "class_list": "", "function": "Expression of Taar family members is limited to specific tissue subpopulations and developmental stages in mouse., [RefSeq, PubMed]; Olfactory receptor specific for N,N-dimethylalkylamines trace amines. Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors. Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q923Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923Y3-1", "uniprot_id": "TAA8B_RAT", "mass": 38044.0, "length": 344, "protein_name": "Trace amine-associated receptor 8b", "gene_name": "Taar8b", "organism": "Rat", "refseq_name": "trace amine-associated receptor 8b", "refseq_ac": "NP_783191", "gene_names_uniprotkb": "Taar8b; Ta7; Tar7; Trar7", "gene_names_refseq": "Ta7; Taar8b", "protein_names_uniprotkb": "Trace amine-associated receptor 8b; TaR-7; TaR-8b; Trace amine receptor 7; Trace amine receptor 8b", "protein_names_refseq": "taR-7; taR-8b; trace amine receptor 7; trace amine receptor 8b; trace amine-associated receptor 8b", "tax_id": 10116, "disease": "", "pathway": " (rno:319106)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11459929", "class_list": "", "function": "Olfactory receptor activated by trace amines. Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors. Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q923Y3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923Y5-1", "uniprot_id": "TAAR6_RAT", "mass": 38311.0, "length": 345, "protein_name": "Trace amine-associated receptor 6", "gene_name": "Taar6", "organism": "Rat", "refseq_name": "trace amine-associated receptor 6", "refseq_ac": "NP_783174", "gene_names_uniprotkb": "Taar6; Ta4; Tar4; Trar4", "gene_names_refseq": "TRAR4; Ta4; Taar6", "protein_names_uniprotkb": "Trace amine-associated receptor 6; TaR-4; TaR-6; Trace amine receptor 4; Trace amine receptor 6", "protein_names_refseq": "taR-4; taR-6; trace amine receptor 4; trace amine receptor 6; trace amine-associated receptor 6", "tax_id": 10116, "disease": "", "pathway": " (rno:294124); (R-RNO-375280)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11459929;29393594", "class_list": "", "function": "Olfactory receptor specific for trace amines, such as beta-phenylethylamine (beta-PEA). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors. Beta-PEA-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q923Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923Y7-1", "uniprot_id": "TAAR4_RAT", "mass": 38783.0, "length": 347, "protein_name": "Trace amine-associated receptor 4", "gene_name": "Taar4", "organism": "Rat", "refseq_name": "trace amine-associated receptor 4", "refseq_ac": "NP_783173", "gene_names_uniprotkb": "Taar4; Ta2; Tar2; Trar2", "gene_names_refseq": "Ta2; Taar4; taR-2; taR-4", "protein_names_uniprotkb": "Trace amine-associated receptor 4; 2-phenylethylamine receptor; TaR-2; TaR-4; Trace amine receptor 2; Trace amine receptor 4", "protein_names_refseq": "2-phenylethylamine receptor; trace amine receptor 2; trace amine receptor 4; trace amine-associated receptor 4", "tax_id": 10116, "disease": "", "pathway": " (rno:294122)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11459929;23072560", "class_list": "", "function": "Olfactory receptor specific for 2-phenylethylamine, a trace amine present at high concentration in the urine of carnivore species, playing a key role in fear and avoidance responses. 2-phenylethylamine acts as a kairomone in the chemical detection of carnivore odor and triggers fear in rats. This receptor is probably mediated by the G(s)-class of G proteins which activate adenylate cyclase., [UniProtKB, UniProtKB]; The different functionality of rat Taar subtypes 1 and 4 mainly correlates with receptor's cell surface expression rather than with specific amino acid residues involved in ligand binding specificity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity;GO:0008227 G protein-coupled amine receptor activity;GO:1990080 2-phenylethylamine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0001662 behavioral fear response;GO:0007635 chemosensory behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q923Y7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J86-1", "uniprot_id": "ATRN_RAT", "mass": 158673.0, "length": 1432, "protein_name": "Attractin", "gene_name": "Atrn", "organism": "Rat", "refseq_name": "attractin precursor", "refseq_ac": "NP_112641", "gene_names_uniprotkb": "Atrn", "gene_names_refseq": "Atrn", "protein_names_uniprotkb": "Attractin; Protein zitter", "protein_names_refseq": "attractin precursor; membrane attractin; protein zitter", "tax_id": 10116, "disease": "", "pathway": " (rno:83526)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11209055;12379762;18302151;19931230;21454685;24090084;36621889;38843836", "class_list": "", "function": "Atrn is more widely expressed throughout the CNS than previously reported, and expression of Atrn by various cell types suggests that Atrn may serve multiple functions in the CNS., [RefSeq, PubMed]; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines (By similarity). May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Mutation of the attractin gene impairs working memory in rats., [RefSeq, PubMed]; There is myelin vacuolation in rats with a null mutation in the gene., [RefSeq, PubMed]; This study indicated that myelinogenesis but not oligodendrogenesis is severely altered both in the white and gray matter of attractin-deficient mv rats., [RefSeq, PubMed]", "predicted_glycosites": 24, "predicted_n_glycosites": 24, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 25, "binding_glycan_count": 0, "secondary_ac_list": "Q99PW0", "ec_number_list": "", "go_molecular_function": "GO:0005112 Notch binding;GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0006979 response to oxidative stress;GO:0040014 regulation of multicellular organism growth;GO:0042552 myelination;GO:0043473 pigmentation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99J86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JD2-1", "uniprot_id": "TEKT1_RAT", "mass": 48591.0, "length": 418, "protein_name": "Tektin-1", "gene_name": "Tekt1", "organism": "Rat", "refseq_name": "tektin-1", "refseq_ac": "NP_445960", "gene_names_uniprotkb": "Tekt1", "gene_names_refseq": "Tekt1", "protein_names_uniprotkb": "Tektin-1", "protein_names_refseq": "tektin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:85270)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99JD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99M66-1", "uniprot_id": "B2L10_RAT", "mass": 21859.0, "length": 185, "protein_name": "Bcl-2-like protein 10", "gene_name": "Bcl2l10", "organism": "Rat", "refseq_name": "bcl-2-like protein 10", "refseq_ac": "NP_446185", "gene_names_uniprotkb": "Bcl2l10; Bcl-b; Boo; Diva", "gene_names_refseq": "Bcl2l10", "protein_names_uniprotkb": "Bcl-2-like protein 10; Anti-apoptotic protein Boo; Apoptosis regulator Bcl-B; Bcl2-L-10", "protein_names_refseq": "BCL2-like 10 (apoptosis facilitator); anti-apoptotic protein Boo; apoptosis regulator Bcl-B; bcl-2-like protein 10; bcl2-L-10", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); breast carcinoma (Disease Ontology:DOID:3459); stomach carcinoma (Disease Ontology:DOID:5517); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:114552)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12787069;17532299;22905226", "class_list": "", "function": "Diva plays an important role in controlling the survival of BMSCs, [RefSeq, PubMed]; Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (By similarity). Increases binding of AHCYL1/IRBIT to ITPR1 (By similarity). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (By similarity). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0015267 channel activity;GO:0089720 caspase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0001836 release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99M66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99M76-1", "uniprot_id": "STAG3_RAT", "mass": 141951.0, "length": 1256, "protein_name": "Cohesin subunit SA-3", "gene_name": "Stag3", "organism": "Rat", "refseq_name": "cohesin subunit SA-3", "refseq_ac": "NP_446182", "gene_names_uniprotkb": "Stag3", "gene_names_refseq": "Stag3", "protein_names_uniprotkb": "Cohesin subunit SA-3; SCC3 homolog 3; Stromal antigen 3; Stromalin-3", "protein_names_refseq": "SCC3 homolog 3; cohesin subunit SA-3-like; cohesin subunit SA-3; stromal antigen 3; stromalin-3", "tax_id": 10116, "disease": "primary ovarian insufficiency 8 (Disease Ontology:DOID:0080865); spermatogenic failure 61 (Disease Ontology:DOID:0112350)", "pathway": " (rno:114522)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11599053", "class_list": "", "function": "Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate., [UniProtKB, UniProtKB, UniProtKB]; Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0030893 meiotic cohesin complex;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0007129 homologous chromosome pairing at meiosis;GO:0051321 meiotic cell cycle;GO:0034502 protein localization to chromosome;GO:0007062 sister chromatid cohesion;GO:0034089 establishment of meiotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99M76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MB4-1", "uniprot_id": "ZNG1_RAT", "mass": 43931.0, "length": 394, "protein_name": "Zinc-regulated GTPase metalloprotein activator 1", "gene_name": "Zng1a; Zng1", "organism": "Rat", "refseq_name": "zinc-regulated GTPase metalloprotein activator 1", "refseq_ac": "NP_598219", "gene_names_uniprotkb": "Zng1a; Zng1; Cbwd1", "gene_names_refseq": "Cbwd1; Zng1a; Zng1", "protein_names_uniprotkb": "Zinc-regulated GTPase metalloprotein activator 1; 3.6.5.-; COBW domain-containing protein 1; Cobalamin synthase W domain-containing protein 1", "protein_names_refseq": "COBW domain containing 1; COBW domain-containing protein 1; cobalamin synthase W domain-containing protein 1; cobalamin synthetase W domain-containing protein 1; dopamine responsive protein; zinc-regulated GTPase metalloprotein activator 1", "tax_id": 10116, "disease": "congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205)", "pathway": " (rno:171057)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1 to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RK12", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0140827 zinc chaperone activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001822 kidney development;GO:0051604 protein maturation;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99MB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99P75-1", "uniprot_id": "RAB9A_RAT", "mass": 22896.0, "length": 201, "protein_name": "Ras-related protein Rab-9A", "gene_name": "Rab9a", "organism": "Rat", "refseq_name": "ras-related protein Rab-9A", "refseq_ac": "NP_445910", "gene_names_uniprotkb": "Rab9a; Rab9", "gene_names_refseq": "Rab9a; Rab9", "protein_names_uniprotkb": "Ras-related protein Rab-9A; 3.6.5.2", "protein_names_refseq": "RAB9, member RAS oncogene family; rab-9A; ras-related protein Rab-9A", "tax_id": 10116, "disease": "", "pathway": " (rno:84589); (R-RNO-6811440); (R-RNO-8873719); (R-RNO-8876198); (R-RNO-9706019)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "12051767;16885419;29574782", "class_list": "", "function": "IGF-IIR predominantly induces mitophagy through the Rab9-dependent alternative autophagy. Erratum:[J Cell Physiol. 2020 Jan;235(1):619. doi: 10.1002/jcp.28951. PMID: 31587273], [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9A is involved in the transport of proteins between the endosomes and the trans-Golgi network (TGN). Specifically uses NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (By similarity). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NS34", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;2.5.1.60;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0032880 regulation of protein localization;GO:0006898 receptor-mediated endocytosis;GO:0042147 retrograde transport, endosome to Golgi;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99P75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PD6-1", "uniprot_id": "TGFI1_RAT", "mass": 50123.0, "length": 461, "protein_name": "Transforming growth factor beta-1-induced transcript 1 protein", "gene_name": "Tgfb1i1", "organism": "Rat", "refseq_name": "transforming growth factor beta-1-induced transcript 1 protein", "refseq_ac": "NP_001178769", "gene_names_uniprotkb": "Tgfb1i1; Ara55", "gene_names_refseq": "Ara55; Hic-5; Tgfb1i1", "protein_names_uniprotkb": "Transforming growth factor beta-1-induced transcript 1 protein; Androgen receptor-associated protein of 55 kDa; Hic-5; Hydrogen peroxide-inducible clone 5 protein", "protein_names_refseq": "androgen receptor-associated protein of 55 kDa; hydrogen peroxide-inducible clone 5 protein; transforming growth factor beta-1-induced transcript 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:84574)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10330411;10848625;11134073;11546764;12153727;12177201;15561701;16546139;21996749;22673903;23508044;26405299;26759173;37156857;9422762;9597752;9756887", "class_list": "", "function": "Data indicate that there is a prosclerotic feedback loop in mesangial cells dependent on matrix-derived signals in which Hic-5 is a pivotal signaling protein. This feedback loop is TGF-beta-independent, [RefSeq, PubMed]; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hypothesized that reducing collagen I accumulation in glomerulosclerosis would lower Hic-5 expression,reducing apoptosis, and maintain glomerular integrity. NTU281 treatment reduced glomerular col I accumulation, Hic-5 and alpha-SMA expression, and apoptosis., [RefSeq, PubMed]; Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13. Erratum:[Sci Rep. 2023 Jun 13;13(1):9589. doi: 10.1038/s41598-023-36393-w. PMID: 37311826] Publication Status: Online-Only, [RefSeq, PubMed]; The C terminus of ARA55 is critical for suppression of Smad3 activity, [RefSeq, PubMed]; The reciprocal regulation of MRTF-A localization by Hic-5 and Hic-5 expression by MRTF-A, plays a crucial role in myofibroblast differentiation in response to TGF-beta., [RefSeq, PubMed]; These results provide the first evidence for a physical and mutual functional interaction between Hic-5 and the BMP signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding;GO:0050681 nuclear androgen receptor binding;GO:0048495 Roundabout binding;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0016363 nuclear matrix", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0016331 morphogenesis of embryonic epithelium;GO:0034446 substrate adhesion-dependent cell spreading;GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99PD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PM1-1", "uniprot_id": "TOX4_RAT", "mass": 66010.0, "length": 619, "protein_name": "TOX high mobility group box family member 4", "gene_name": "Tox4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tox4", "gene_names_refseq": "", "protein_names_uniprotkb": "TOX high mobility group box family member 4; Epidermal Langerhans cell protein LCP1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate. In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation. Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes. Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (By similarity). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0072357 PTW/PP1 phosphatase complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001111 RNA polymerase II promoter clearance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99PM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPI0-1", "uniprot_id": "XYLT2_RAT", "mass": 96790.0, "length": 864, "protein_name": "Xylosyltransferase 2", "gene_name": "Xylt2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Xylt2", "gene_names_refseq": "", "protein_names_uniprotkb": "Xylosyltransferase 2; 2.4.2.26; Peptide O-xylosyltransferase 2; Xylosyltransferase II", "protein_names_refseq": "", "tax_id": 10116, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); pseudoxanthoma elasticum (Disease Ontology:DOID:2738)", "pathway": " (R-RNO-1971475)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11099377", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN (By similarity). Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.26", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0030158 protein xylosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EPI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQS0-1", "uniprot_id": "TALDO_RAT", "mass": 37460.0, "length": 337, "protein_name": "Transaldolase", "gene_name": "Taldo1", "organism": "Rat", "refseq_name": "transaldolase", "refseq_ac": "NP_113999", "gene_names_uniprotkb": "Taldo1", "gene_names_refseq": "Taldo1", "protein_names_uniprotkb": "Transaldolase; 2.2.1.2", "protein_names_refseq": "transaldolase", "tax_id": 10116, "disease": "carbohydrate metabolic disorder (Disease Ontology:DOID:2978)", "pathway": " (rno:83688); (R-RNO-163754); (R-RNO-71336)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "18683930;22673903;23235149", "class_list": "", "function": "Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; [U-13C3]glycerol is transferred exclusively to carbons 4-6 of glucosyl units with no enrichment in carbons 1-3. which is explained by carbon rearrangements occurring at the level of transaldolase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCV1", "ec_number_list": "2.2.1.2", "go_molecular_function": "GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0004801 transaldolase activity;GO:0048029 monosaccharide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0019682 glyceraldehyde-3-phosphate metabolic process;GO:0009052 pentose-phosphate shunt, non-oxidative branch;GO:0005975 carbohydrate metabolic process;GO:0006098 pentose-phosphate shunt;GO:0006002 fructose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EQS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQV8-1", "uniprot_id": "CBPN_RAT", "mass": 51981.0, "length": 457, "protein_name": "Carboxypeptidase N catalytic chain", "gene_name": "Cpn1", "organism": "Rat", "refseq_name": "carboxypeptidase N catalytic chain precursor", "refseq_ac": "NP_445978", "gene_names_uniprotkb": "Cpn1", "gene_names_refseq": "Cpn1; Cpn", "protein_names_uniprotkb": "Carboxypeptidase N catalytic chain; 3.4.17.3; CPN; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit", "protein_names_refseq": "carboxypeptidase N catalytic chain precursor; carboxypeptidase N catalytic chain-like; carboxypeptidase N catalytic chain; carboxypeptidase N small subunit; carboxypeptidase N, polypeptide 1, 50kD", "tax_id": 10116, "disease": "carboxypeptidase N deficiency (Disease Ontology:DOID:0111583)", "pathway": " (rno:365466); (R-RNO-977606)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11021404", "class_list": "", "function": "Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.17.3;3.4.17.20", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016485 protein processing;GO:0051384 response to glucocorticoid;GO:0006518 peptide metabolic process;GO:0030163 protein catabolic process;GO:0010815 bradykinin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EQV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQX9-1", "uniprot_id": "UBE2N_RAT", "mass": 17124.0, "length": 152, "protein_name": "Ubiquitin-conjugating enzyme E2 N", "gene_name": "Ube2n", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 N", "refseq_ac": "NP_446380", "gene_names_uniprotkb": "Ube2n", "gene_names_refseq": "Ube2n", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 N; 2.3.2.23; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubiquitin carrier protein N; Ubiquitin-protein ligase N", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme N; bendless protein; bendless-like ubiquitin-conjugating enzyme; ubiquitin carrier protein N; ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-protein ligase N", "tax_id": 10116, "disease": "", "pathway": " (rno:116725); (R-RNO-1169408); (R-RNO-168638); (R-RNO-202424); (R-RNO-2871837); (R-RNO-445989); (R-RNO-450302); (R-RNO-450321); (R-RNO-5205685); (R-RNO-5607764); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-5696395); (R-RNO-69473); (R-RNO-8866654); (R-RNO-9020702); (R-RNO-937039); (R-RNO-937041); (R-RNO-9646399); (R-RNO-975144); (R-RNO-983168)", "pathway_count": 22, "publication_count": 2, "publication_id_list": "22673903;29097665", "class_list": "", "function": "Knockdown or conditional knockout of RNF8 or UBC13 in rodent cerebellar granule neurons robustly increases the number of parallel fiber presynaptic boutons and functional parallel fiber/Purkinje cell synapses. In contrast to the role of nuclear RNF8 in proliferating cells, RNF8 operates in the cytoplasm in neurons to suppress synapse differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.32;2.7.11.1;1.14.11.69;1.14.11.66;2.3.2.31;2.3.2.23;2.3.2.27;2.3.2.34;2.3.2.24;5.6.2.3;2.4.2.-;2.7.12.2;2.3.2.-;3.4.19.-;2.3.2.25;6.2.1.45;2.1.1.357;6.3.2.n3;2.7.10.2;2.7.11.10;3.1.2.-;3.5.1.-;3.5.1.124;2.7.11.25;2.4.2.30;5.6.1.6;3.1.3.16;5.6.2.4;1.14.11.-;3.1.-.-;3.6.5.-;6.2.1.64;2.3.1.48;2.3.1.-;3.6.-.-;2.7.11.13", "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0043130 ubiquitin binding;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045739 positive regulation of DNA repair;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EQX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERH3-1", "uniprot_id": "WDR7_RAT", "mass": 163191.0, "length": 1488, "protein_name": "WD repeat-containing protein 7", "gene_name": "Wdr7", "organism": "Rat", "refseq_name": "WD repeat-containing protein 7 isoform 1", "refseq_ac": "NP_076465", "gene_names_uniprotkb": "Wdr7; Trag", "gene_names_refseq": "Trag; Wd7; Wdr7", "protein_names_uniprotkb": "WD repeat-containing protein 7; TGF-beta resistance-associated protein TRAG", "protein_names_refseq": "TGF-beta resistance-associated protein TRAG; WD repeat-containing protein 7 isoform 1; WD repeat-containing protein 7; rabconnectin-3beta", "tax_id": 10116, "disease": "", "pathway": " (rno:66031)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q920I8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ERH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHJ1-1", "uniprot_id": "RAMP2_RAT", "mass": 20300.0, "length": 182, "protein_name": "Receptor activity-modifying protein 2", "gene_name": "Ramp2", "organism": "Rat", "refseq_name": "receptor activity-modifying protein 2 precursor", "refseq_ac": "NP_113834", "gene_names_uniprotkb": "Ramp2", "gene_names_refseq": "Ramp2", "protein_names_uniprotkb": "Receptor activity-modifying protein 2", "protein_names_refseq": "receptor (G protein-coupled) activity modifying protein 2; receptor (calcitonin) activity modifying protein 2; receptor activity-modifying protein 2 precursor", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); adult respiratory distress syndrome (Disease Ontology:DOID:11394); kidney disease (Disease Ontology:DOID:557); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:58966); (R-RNO-419812); (R-RNO-9856530)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10733909;11230971;11556887;24505304;25061099;26927337", "class_list": "", "function": "Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:11556887). Required for the transport of CALCRL to the plasma membrane (By similarity). Together with CALCRL, form a receptor complex for adrenomedullin/ADM (PubMed:11556887). Together with CALCR, act as a receptor complex for calcitonin/CT/CALC. Together with CALCR, also act as a receptor complex for amylin/IAPP (By similarity)., [UniProtKB, PubMed, UniProtKB]; Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that stimulation of adrenomedullin/adrenomedullin receptor signaling enhances trophoblast stem cell differentiation; this stimulation involves CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor activity-modifying protein 2)., [RefSeq, PubMed]; Increased expression of IMD and all its receptor components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within the aorta of rats with Hypercholesterolemia., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0001664 G protein-coupled receptor binding;GO:0001605 adrenomedullin receptor activity;GO:1990409 adrenomedullin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:1903143 adrenomedullin receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0006886 intracellular protein transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JHJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHX0-1", "uniprot_id": "RGS2_RAT", "mass": 24323.0, "length": 211, "protein_name": "Regulator of G protein signaling 2", "gene_name": "Rgs2", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 2", "refseq_ac": "NP_445905", "gene_names_uniprotkb": "Rgs2", "gene_names_refseq": "Rgs2", "protein_names_uniprotkb": "Regulator of G protein signaling 2; RGS2", "protein_names_refseq": "regulator of G-protein signaling 2; regulator of G-protein signaling protein 2", "tax_id": 10116, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); hypertension (Disease Ontology:DOID:10763); opioid abuse (Disease Ontology:DOID:11206); bladder disease (Disease Ontology:DOID:365); liver cirrhosis (Disease Ontology:DOID:5082); female stress incontinence (Disease Ontology:DOID:724)", "pathway": " (rno:84583); (R-RNO-416476)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10692485;11409749;23587726;24576550;26606876", "class_list": "", "function": "Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Stress-induced transcription of regulator of G protein signaling 2 (RGS2) by heat shock transcription factor HSF1, [RefSeq, PubMed]; The protective effects of RGS2 in cardiac hypertrophy may derive at least in part from its ability to govern protein synthesis., [RefSeq, PubMed]; These results suggest that Dahl S rats exhibit a blunted RGS2 response to Ang-II, and this blunted response may be partially responsible for the susceptibility to renal injury in Dahl S rats., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding;GO:0048487 beta-tubulin binding;GO:0010855 adenylate cyclase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0071877 regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway;GO:0007283 spermatogenesis;GO:0010976 positive regulation of neuron projection development;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JHX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIR0-1", "uniprot_id": "RIMB1_RAT", "mass": 200204.0, "length": 1847, "protein_name": "Peripheral-type benzodiazepine receptor-associated protein 1", "gene_name": "Tspoap1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tspoap1; Bzrap1; Rbp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Peripheral-type benzodiazepine receptor-associated protein 1; PRAX-1; RIM-BP1; RIMS-binding protein 1; TSPO-associated protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "dystonia 22, juvenile-onset (Disease Ontology:DOID:0060966); dystonia 22, adult-onset (Disease Ontology:DOID:0060967)", "pathway": " (rno:287609); (R-RNO-181429); (R-RNO-181430); (R-RNO-196108); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "10748113;12435798;9915832", "class_list": "", "function": "Required for synaptic transmission regulation. It probably controls the recruitment of voltage-gated calcium channels to the presynaptic membrane, and modulates neurotransmitter release., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIQ9", "ec_number_list": "", "go_molecular_function": "GO:0030156 benzodiazepine receptor binding;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JIR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIR3-1", "uniprot_id": "RIMS3_RAT", "mass": 32651.0, "length": 307, "protein_name": "Regulating synaptic membrane exocytosis protein 3", "gene_name": "Rims3", "organism": "Rat", "refseq_name": "regulating synaptic membrane exocytosis protein 3", "refseq_ac": "NP_075220", "gene_names_uniprotkb": "Rims3; Nim3", "gene_names_refseq": "Nim2; Nim3; RIM 3; Rims3", "protein_names_uniprotkb": "Regulating synaptic membrane exocytosis protein 3; Nim3; RIM 3; RIM3 gamma; Rab-3-interacting molecule 3", "protein_names_refseq": "RIM3 gamma; rab-3-interacting molecule 3; regulating synaptic membrane exocytosis protein 3", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:65025)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10748113;12620390;22673903;23303958", "class_list": "", "function": "Gamma-RIMs are involved in cell biological functions distinct from the regulation of synaptic vesicle exocytosis and play a role in the molecular mechanisms controlling the establishment of dendritic complexity and axonal outgrowth, [RefSeq, PubMed]; Regulates synaptic membrane exocytosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0044325 transmembrane transporter binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0042734 presynaptic membrane;GO:0099524 postsynaptic cytosol;GO:0016020 membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0017156 calcium-ion regulated exocytosis;GO:0050807 regulation of synapse organization;GO:0016082 synaptic vesicle priming;GO:0016081 synaptic vesicle docking", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JIR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJ73-1", "uniprot_id": "RAMP3_RAT", "mass": 16781.0, "length": 147, "protein_name": "Receptor activity-modifying protein 3", "gene_name": "Ramp3", "organism": "Rat", "refseq_name": "receptor activity-modifying protein 3 precursor", "refseq_ac": "NP_064485", "gene_names_uniprotkb": "Ramp3", "gene_names_refseq": "Ramp3", "protein_names_uniprotkb": "Receptor activity-modifying protein 3", "protein_names_refseq": "receptor (G protein-coupled) activity modifying protein 3; receptor (calcitonin) activity modifying protein 3; receptor activity-modifying protein 3 precursor", "tax_id": 10116, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:56820); (R-RNO-419812)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11230971;11556887;26927337", "class_list": "", "function": "Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G protein-coupled estrogen receptor 1 (GPER1) (PubMed:11556887). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (By similarity). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed:11556887). Together with CALCR, act as a receptor complex for amylin/IAPP (By similarity)., [UniProtKB, PubMed, UniProtKB]; Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2. Together with CALCR, act as a receptor complex for amylin/IAPP., [UniProtKB, UniProtKB]; Increased expression of IMD and all its receptor components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within the aorta of rats with Hypercholesterolemia., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0001664 G protein-coupled receptor binding;GO:0001605 adrenomedullin receptor activity;GO:0097643 amylin receptor activity;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0005764 lysosome;GO:0150058 amylin receptor complex 3", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JJ73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJ74-1", "uniprot_id": "RAMP1_RAT", "mass": 16815.0, "length": 148, "protein_name": "Receptor activity-modifying protein 1", "gene_name": "Ramp1", "organism": "Rat", "refseq_name": "receptor activity-modifying protein 1 precursor", "refseq_ac": "NP_113833", "gene_names_uniprotkb": "Ramp1", "gene_names_refseq": "Ramp1", "protein_names_uniprotkb": "Receptor activity-modifying protein 1", "protein_names_refseq": "receptor (G protein-coupled) activity modifying protein 1; receptor (calcitonin) activity modifying protein 1; receptor activity-modifying protein 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:58965); (R-RNO-419812)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11230971;11556887;21040789;22038237;22208649;26927337", "class_list": "", "function": "Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:11556887). Required for the transport of CALCRL to the plasma membrane (By similarity). Together with CALCRL, form the receptor complex for the calcitonin gene-related peptides CGRP1/CALCA and CGRP2/CALCB (PubMed:11556887). Together with CALCR, form the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA (By similarity)., [UniProtKB, PubMed, UniProtKB]; After traumatic injury to periodontal ligament, CGRP nerve fibers appear in close vicinity of small and large receptor activity modifying protein (RAMP)1 cells at 5-7 days., [RefSeq, PubMed]; Data demonstrate that there is a rich expression of calcitonin gene-related peptide (CGRP) and its receptor elements CLR and RAMP1 in the cerebellum which points towards a functional role of CGRP in cerebellar Purkinje cells., [RefSeq, PubMed]; Increased expression of IMD and all its receptor components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within the aorta of rats with Hypercholesterolemia., [RefSeq, PubMed]; The present finding demonstrated that RAMP1 immunoreactivity was localized in many neurons and phenopalatine ganglion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0001664 G protein-coupled receptor binding;GO:0001635 calcitonin gene-related peptide receptor activity;GO:0097643 amylin receptor activity;GO:1990407 calcitonin gene-related peptide binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0006886 intracellular protein transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJ74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJL4-1", "uniprot_id": "RHOQ_RAT", "mass": 22645.0, "length": 205, "protein_name": "Rho-related GTP-binding protein RhoQ", "gene_name": "Rhoq", "organism": "Rat", "refseq_name": "rho-related GTP-binding protein RhoQ", "refseq_ac": "NP_445974", "gene_names_uniprotkb": "Rhoq; Rhoq-ps1; Tc10", "gene_names_refseq": "Rhoq; Tc10", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoQ; 3.6.5.2; Ras-like protein TC10", "protein_names_refseq": "ras homolog gene family, member Q; ras-like protein TC10; ras-related GTP-binding protein TC10; rho-related GTP-binding protein RhoQ", "tax_id": 10116, "disease": "", "pathway": " (rno:85428); (R-RNO-5627083); (R-RNO-9013406)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10818149;16105861;24297911", "class_list": "", "function": "Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia., [UniProtKB]; Results demonstrate that the impairment in insulin-stimulated glucose transport observed in adipocytes after chronic ethanol feeding to rats is associated with a disruption of insulin-mediated Cbl protein/TC10 GTPase signaling, [RefSeq, PubMed]; The enhancement of Cb-induced gephyrin clustering by GTP-TC10 does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;2.7.11.1;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.3.2.26;3.6.5.5;3.6.1.5;5.6.1.6;3.6.1.-;1.16.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0005522 profilin binding;GO:0032427 GBD domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JJL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJW1-1", "uniprot_id": "TSN2_RAT", "mass": 24190.0, "length": 221, "protein_name": "Tetraspanin-2", "gene_name": "Tspan2", "organism": "Rat", "refseq_name": "tetraspanin-2", "refseq_ac": "NP_072111", "gene_names_uniprotkb": "Tspan2", "gene_names_refseq": "Tspan-2; Tspan2", "protein_names_uniprotkb": "Tetraspanin-2; Tspan-2", "protein_names_refseq": "tetraspan 2; tetraspanin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:64521)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10582623;24090084", "class_list": "", "function": "May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 7, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 33, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0043209 myelin sheath", "go_biological_process": "GO:0006954 inflammatory response;GO:0014005 microglia development;GO:0042552 myelination;GO:0014002 astrocyte development;GO:0061564 axon development", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q9JJW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKE7-1", "uniprot_id": "T2R41_RAT", "mass": 36010.0, "length": 308, "protein_name": "Taste receptor type 2 member 41", "gene_name": "Tas2r41", "organism": "Rat", "refseq_name": "taste receptor type 2 member 41", "refseq_ac": "NP_647551", "gene_names_uniprotkb": "Tas2r41; Tas2r126; Tas2r12", "gene_names_refseq": "Tas2r126; Tas2r41", "protein_names_uniprotkb": "Taste receptor type 2 member 41; T2R12; T2R41; Taste receptor type 2 member 126", "protein_names_refseq": "T2R12; T2R41; taste receptor rT2R12; taste receptor type 2 member 41", "tax_id": 10116, "disease": "", "pathway": " (rno:246219); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10761934;10761935;11696554;11854532;12139982;12581520", "class_list": "", "function": "Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKE9-1", "uniprot_id": "TA2R7_RAT", "mass": 35844.0, "length": 312, "protein_name": "Taste receptor type 2 member 7", "gene_name": "Tas2r7", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tas2r7; Tas2r130; Tas2r6", "gene_names_refseq": "", "protein_names_uniprotkb": "Taste receptor type 2 member 7; T2R6; T2R7; Taste receptor type 2 member 130; Taste receptor type 2 member 6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10761934;10761935;11696554;11854532;12139982;12581520", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q67ET9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKT7-1", "uniprot_id": "T2R13_RAT", "mass": 35595.0, "length": 305, "protein_name": "Taste receptor type 2 member 13", "gene_name": "Tas2r13", "organism": "Rat", "refseq_name": "taste receptor type 2 member 13", "refseq_ac": "NP_076487", "gene_names_uniprotkb": "Tas2r13; Tas2r121; Tas2r7", "gene_names_refseq": "T2R7; Tas2r121; Tas2r13; Tas2r7", "protein_names_uniprotkb": "Taste receptor type 2 member 13; T2R13; T2R7; Taste receptor type 2 member 121; Taste receptor type 2 member 7", "protein_names_refseq": "T2R13; taste receptor T2R7; taste receptor type 2 member 13; taste receptor type 2 member 7", "tax_id": 10116, "disease": "", "pathway": " (rno:78983); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10761934;10761935;11696554;11854532;12139982;12581520", "class_list": "", "function": "Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0032467 positive regulation of cytokinesis;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKU0-1", "uniprot_id": "T2R16_RAT", "mass": 34642.0, "length": 299, "protein_name": "Taste receptor type 2 member 16", "gene_name": "Tas2r16", "organism": "Rat", "refseq_name": "taste receptor type 2 member 16", "refseq_ac": "NP_076484", "gene_names_uniprotkb": "Tas2r16; Tas2r118; Tas2r18; Tas2r3", "gene_names_refseq": "T2R3; Tas2r118; Tas2r16", "protein_names_uniprotkb": "Taste receptor type 2 member 16; T2R16; T2R18; T2R3; Taste receptor type 2 member 118", "protein_names_refseq": "T2R16; T2R18; taste receptor type 2 member 16", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (rno:78980); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10761934;10761935;11696554;11854532;12139982;12581520", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXY8-1", "uniprot_id": "CCL7_RAT", "mass": 10906.0, "length": 97, "protein_name": "C-C motif chemokine 7", "gene_name": "Ccl7", "organism": "Rat", "refseq_name": "C-C motif chemokine 7 precursor", "refseq_ac": "NP_001007613", "gene_names_uniprotkb": "Ccl7; Mcp3; Scya7", "gene_names_refseq": "Ccl7", "protein_names_uniprotkb": "C-C motif chemokine 7; MCP-3; Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; Small-inducible cytokine A7", "protein_names_refseq": "C-C motif chemokine 7 precursor; C-C motif chemokine 7; MCP-3; chemokine (C-C motif) ligand 7; chemotactic protein-3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; small-inducible cytokine A7", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); silicosis (Disease Ontology:DOID:10325); interstitial nephritis (Disease Ontology:DOID:1063); allergic conjunctivitis (Disease Ontology:DOID:11204); multiple sclerosis (Disease Ontology:DOID:2377); nephrosis (Disease Ontology:DOID:2527); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483); periapical granuloma (Disease Ontology:DOID:4617); pneumonia (Disease Ontology:DOID:552); periapical periodontitis (Disease Ontology:DOID:823); ulcerative colitis (Disease Ontology:DOID:8577); viral infectious disease (Disease Ontology:DOID:934); ethmoid sinusitis (Disease Ontology:DOID:9507); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:287561); (R-RNO-380108)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10521584;27295026;37021908", "class_list": "", "function": "Chemotactic factor that plays an important role in immune regulation. Attracts monocytes, eosinophils, basophils, and T-cells to sites of inflammation or infection. Upon binding to various chemokine receptors including CCR1, CCR2, CCR3, and CCR5, facilitates immune cell migration by guiding them to infected tissues. Interacts with CCR2 to facilitate the release of monocytes from the bone marrow into the bloodstream, maintaining monocyte homeostasis. In turn, monocytes recruited to inflamed or injured tissues can differentiate into macrophages or dendritic cells, which are essential for immune defense and tissue repair. Through CCR1, contributes to macrophage polarization via NF-kappa-B activation which leads to the release of inflammatory factors. In the trigeminal ganglion neurons, activates ERK via CCR2 and CCR3 to enhance neuronal excitability, which contributes to the maintenance of trigeminal neuropathic pain. Additionally, modulates the early immune response in the skin, preventing pathogen dissemination while maintaining cutaneous immune control., [UniProtKB, UniProtKB, UniProtKB]; HDAC2 exacerbates rheumatoid arthritis progression via the IL-17-CCL7 signaling pathway., [RefSeq, PubMed]; This study demonstrated that that Ccl7 promoted astrocyte proliferation and thus contributed toward neuropathic pain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0031726 CCR1 chemokine receptor binding;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding;GO:0031727 CCR2 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0010332 response to gamma radiation;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QXY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZG1-1", "uniprot_id": "S22AN_RAT", "mass": 74208.0, "length": 689, "protein_name": "Solute carrier family 22 member 23", "gene_name": "Slc22a23", "organism": "Rat", "refseq_name": "solute carrier family 22 member 23", "refseq_ac": "NP_072146", "gene_names_uniprotkb": "Slc22a23; Nritp", "gene_names_refseq": "Nritp; Slc22a23", "protein_names_uniprotkb": "Solute carrier family 22 member 23; Ion transporter protein", "protein_names_refseq": "ion transporter protein; solute carrier family 22 member 23", "tax_id": 10116, "disease": "", "pathway": " (rno:64559)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10719212;17714910;21359964;38843836;39197039", "class_list": "", "function": "Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume. Publication Status: Online-Only, [RefSeq, PubMed]; These novel family members have a nonconserved amino terminus, relative to other organic cation transporters, that may preclude typical SLC22 transport function, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QZG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZX8-2", "uniprot_id": "SO1B2_RAT", "mass": 76767.0, "length": 687, "protein_name": "Solute carrier organic anion transporter family member 1B2", "gene_name": "Slco1b2", "organism": "Rat", "refseq_name": "solute carrier organic anion transporter family member 1B2 isoform 2", "refseq_ac": "NP_001257515", "gene_names_uniprotkb": "Slco1b2; Oatp1b2; Slc21a10", "gene_names_refseq": "OATP-4; Oatp4; Slc21a10; Slco1b2; Slco1b3; rlst-1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1B2; Liver-specific organic anion transporter 1; OATP-4; Sodium-independent organic anion-transporting polypeptide 4; Solute carrier family 21 member 10; rLST-1", "protein_names_refseq": "liver-specific organic anion transporter 1; liver-specific transporter-1; organic anion transporting polypeptide 4; sodium-independent organic anion-transporting polypeptide 4; solute carrier family (organic anion transporter) member 10; solute carrier family 21 (organic anion transporter) member 10; solute carrier family 21 member 10; solute carrier organic anion transporter family member 1B2 isoform 2; solute carrier organic anion transporter family, member 1b3", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); lung cancer (Disease Ontology:DOID:1324); cholestasis (Disease Ontology:DOID:13580); colon carcinoma (Disease Ontology:DOID:1520); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); bilirubin metabolic disorder (Disease Ontology:DOID:2741); testicular cancer (Disease Ontology:DOID:2998); breast ductal carcinoma (Disease Ontology:DOID:3007); liver cancer (Disease Ontology:DOID:3571); hepatocellular carcinoma (Disease Ontology:DOID:684); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (rno:58978); (R-RNO-159418); (R-RNO-189483); (R-RNO-879518); (R-RNO-9754706)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10500057;10838093;10903899;11713643;16396499;19129463;22673903", "class_list": "", "function": "Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates (estrone 3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate) (PubMed:19129463). Also transports prostaglandin E2 and L-thyroxine (T4) (PubMed:19129463). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHF6;Q9JIM2", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity;GO:0035673 oligopeptide transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0001889 liver development;GO:0006811 monoatomic ion transport;GO:0019228 neuronal action potential;GO:0032496 response to lipopolysaccharide;GO:0050905 neuromuscular process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QZX8-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R050-1", "uniprot_id": "SSBP3_RAT", "mass": 37714.0, "length": 361, "protein_name": "Single-stranded DNA-binding protein 3", "gene_name": "Ssbp3", "organism": "Rat", "refseq_name": "single-stranded DNA-binding protein 3 isoform a", "refseq_ac": "NP_445810", "gene_names_uniprotkb": "Ssbp3; Ssdp1; Ssdp3; Ssdp", "gene_names_refseq": "Ssbp3; Ssdp3; Ssdp", "protein_names_uniprotkb": "Single-stranded DNA-binding protein 3; Sequence-specific single-stranded-DNA-binding protein", "protein_names_refseq": "sequence-specific single-stranded-DNA-binding protein; single-stranded DNA-binding protein 3 isoform a", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:84354)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10524251;22673903", "class_list": "", "function": "May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060323 head morphogenesis;GO:0021501 prechordal plate formation;GO:0021547 midbrain-hindbrain boundary initiation;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R050-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1E9-1", "uniprot_id": "CCN2_RAT", "mass": 37756.0, "length": 347, "protein_name": "CCN family member 2", "gene_name": "Ccn2", "organism": "Rat", "refseq_name": "CCN family member 2 precursor", "refseq_ac": "NP_071602", "gene_names_uniprotkb": "Ccn2; Ctgf", "gene_names_refseq": "CTGRP; Ccn2; Ctgf", "protein_names_uniprotkb": "CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; Connective tissue growth-related protein", "protein_names_refseq": "CCN family member 2 precursor; CCN family member 2; connective tissue growth factor; connective tissue growth-related protein", "tax_id": 10116, "disease": "spondyloepimetaphyseal dysplasia, Li-Shao-Li type (Disease Ontology:DOID:0051046); kyphomelic dysplasia (Disease Ontology:DOID:0061155); bone disease (Disease Ontology:DOID:0080001); primary biliary cholangitis (Disease Ontology:DOID:12236); endomyocardial fibrosis (Disease Ontology:DOID:12932); Parkinson's disease (Disease Ontology:DOID:14330); osteochondrodysplasia (Disease Ontology:DOID:2256); ovarian cancer (Disease Ontology:DOID:2394); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); restrictive cardiomyopathy (Disease Ontology:DOID:397); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); aortic valve insufficiency (Disease Ontology:DOID:57); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); tendinitis (Disease Ontology:DOID:971)", "pathway": " (rno:64032)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10393331;10679821;34553456;34797990;36539014;37455557", "class_list": "", "function": "Connective-Tissue Growth Factor Contributes to TGF-beta1-induced Lung Fibrosis., [RefSeq, PubMed]; LncRNA TUG1 acts as a competing endogenous RNA to mediate CTGF expression by sponging miR-133b in myocardial fibrosis after myocardial infarction., [RefSeq, PubMed]; METTL3-dependent m6A modification mediates bladder remodeling after partial bladder outlet obstruction through CCN2 activation., [RefSeq, PubMed]; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MicroRNA-19 upregulation attenuates cardiac fibrosis via targeting connective tissue growth factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53YJ0;Q9WVS1", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0008083 growth factor activity;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005938 cell cortex;GO:0031012 extracellular matrix;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R1E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1T3-1", "uniprot_id": "CATZ_RAT", "mass": 34194.0, "length": 306, "protein_name": "Cathepsin Z", "gene_name": "Ctsz", "organism": "Rat", "refseq_name": "cathepsin Z precursor", "refseq_ac": "NP_899159", "gene_names_uniprotkb": "Ctsz; Ctsy", "gene_names_refseq": "CATX; Ctsz", "protein_names_uniprotkb": "Cathepsin Z; 3.4.18.1; Cathepsin Y", "protein_names_refseq": "cathepsin X; cathepsin Y; cathepsin Z precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:252929); (R-RNO-2022377); (R-RNO-204005); (R-RNO-432720); (R-RNO-5694530); (R-RNO-6798695)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "10615013;12553736", "class_list": "", "function": "Completion of the mRNA sequence resulted in the omission of the strangely attached C-terminal peptide from cathepsin Y, [RefSeq, PubMed]; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10615013, PubMed:12553736). Capable of producing kinin potentiating peptides (PubMed:10615013)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKD9", "ec_number_list": "3.6.5.2;5.2.1.8;5.3.4.1;2.3.1.-;1.1.1.205;3.2.1.23;3.5.4.5;2.3.2.5;3.6.4.13;2.4.1.25;3.2.1.33;4.2.99.18;5.6.2.4;4.1.2.4;2.4.1.186;3.5.4.6;3.1.1.47;2.7.1.35;3.4.24.34;3.2.1.17;3.4.22.1;1.11.1.6;2.5.1.18;4.1.2.13;3.6.5.-;4.2.1.24;3.2.1.31;3.5.3.1;2.3.1.16;2.3.1.9;2.3.1.155;2.4.1.1;2.7.10.2;2.7.11.1;2.7.1.40;1.13.11.-;1.13.11.34;3.4.19.1;2.3.3.8;1.16.3.1;2.7.4.6;2.7.13.3;3.4.23.5;5.4.2.11;5.4.2.4;2.7.1.1;3.3.2.6;3.4.11.4;2.7.1.11;5.3.2.1;5.3.3.12;3.4.21.46;1.4.3.22;1.4.3.-;5.4.2.2;3.6.5.5;1.1.1.42;3.6.4.6;3.4.24.35;3.1.6.12;2.3.2.26;3.6.4.10;2.7.11.24;3.4.14.1;3.1.3.48;2.4.2.1;3.4.22.52;3.4.22.27;2.7.11.26;3.1.21.-;3.5.1.3;3.4.19.9;1.8.3.2;5.3.1.9;5.1.3.-;3.5.1.23;3.5.1.-;3.2.1.166;3.6.1.6;3.2.1.18;3.4.25.1;3.1.22.1;3.4.18.1;1.11.1.24", "go_molecular_function": "GO:0016807 cysteine-type carboxypeptidase activity;GO:0004180 carboxypeptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0009986 cell surface;GO:0030426 growth cone", "go_biological_process": "GO:0006508 proteolysis;GO:0010757 negative regulation of plasminogen activation;GO:0051603 proteolysis involved in protein catabolic process;GO:0060441 epithelial tube branching involved in lung morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R1T3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTL3-1", "uniprot_id": "SEM6C_RAT", "mass": 102610.0, "length": 960, "protein_name": "Semaphorin-6C", "gene_name": "Sema6c", "organism": "Rat", "refseq_name": "semaphorin-6C precursor", "refseq_ac": "NP_059004", "gene_names_uniprotkb": "Sema6c; Semay", "gene_names_refseq": "Sema6c", "protein_names_uniprotkb": "Semaphorin-6C; Sema Y; Semaphorin-Y", "protein_names_refseq": "Sema Y; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C; semaphorin-6C precursor; semaphorin-Y", "tax_id": 10116, "disease": "Jacobsen Syndrome (Disease Ontology:DOID:0111723); Parkinson's disease (Disease Ontology:DOID:14330); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:29744)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10049528", "class_list": "", "function": "Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9WTM6", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0007411 axon guidance;GO:0030517 negative regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WTL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU11-1", "uniprot_id": "SNURF_RAT", "mass": 8436.0, "length": 71, "protein_name": "SNRPN upstream reading frame protein", "gene_name": "Snurf", "organism": "Rat", "refseq_name": "SNURF protein", "refseq_ac": "NP_001257641", "gene_names_uniprotkb": "Snurf", "gene_names_refseq": "Snurf", "protein_names_uniprotkb": "SNRPN upstream reading frame protein", "protein_names_refseq": "SNRPN upstream reading frame protein; SNURF protein", "tax_id": 10116, "disease": "", "pathway": " (rno:113938)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10318933", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WU11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUC4-1", "uniprot_id": "ATOX1_RAT", "mass": 7292.0, "length": 68, "protein_name": "Copper transport protein ATOX1", "gene_name": "Atox1", "organism": "Rat", "refseq_name": "copper transport protein ATOX1", "refseq_ac": "NP_445811", "gene_names_uniprotkb": "Atox1; Rah1", "gene_names_refseq": "Atox1; Atx1", "protein_names_uniprotkb": "Copper transport protein ATOX1; ATX1 homolog protein Rah1; Metal transport protein ATX1", "protein_names_refseq": "ATX1 (antioxidant protein 1) homolog 1; ATX1 antioxidant protein 1 homolog; ATX1 homolog protein Rah1; copper transport protein ATOX1; metal transport protein ATX1", "tax_id": 10116, "disease": "", "pathway": " (rno:84355); (R-RNO-6803544)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10473283;10558899;22442359;37859596", "class_list": "", "function": "Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle., [RefSeq, PubMed]; These results suggest that Ctr1, DMT1, ATOX1 and ATP7A contribute to Cu transport at the blood-CSF barrier, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q549B3", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0005507 copper ion binding;GO:0032767 copper-dependent protein binding;GO:1903136 cuprous ion binding;GO:0016531 copper chaperone activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0006979 response to oxidative stress;GO:0043066 negative regulation of apoptotic process;GO:0006825 copper ion transport;GO:0060003 copper ion export", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WUC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVS2-1", "uniprot_id": "OSGEP_RAT", "mass": 36357.0, "length": 335, "protein_name": "tRNA N6-adenosine threonylcarbamoyltransferase", "gene_name": "Osgep", "organism": "Rat", "refseq_name": "tRNA N6-adenosine threonylcarbamoyltransferase", "refseq_ac": "NP_001093980", "gene_names_uniprotkb": "Osgep; Gcpl1", "gene_names_refseq": "Osgep", "protein_names_uniprotkb": "tRNA N6-adenosine threonylcarbamoyltransferase; 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotein endopeptidase; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgep; tRNA threonylcarbamoyladenosine biosynthesis protein Osgep", "protein_names_refseq": "N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotease; Prsmg1/Gcpl1; pasteurella haemolytica metalloprotease homolog with glycoprotein substrates/gpc-like protein 1; probable O-sialoglycoprotein endopeptidase; probable tRNA N6-adenosine threonylcarbamoyltransferase; probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgep; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgep; tRNA N6-adenosine threonylcarbamoyltransferase", "tax_id": 10116, "disease": "primary hypomagnesemia (Disease Ontology:DOID:0060879); Galloway-Mowat syndrome 3 (Disease Ontology:DOID:0080245); proteinuria (Disease Ontology:DOID:576)", "pathway": " (rno:290028)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10631378", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0BMW7", "ec_number_list": "2.3.1.234", "go_molecular_function": "GO:0046872 metal ion binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0006400 tRNA modification;GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0070525 tRNA threonylcarbamoyladenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WVS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0K6-1", "uniprot_id": "SCRG1_RAT", "mass": 11162.0, "length": 98, "protein_name": "Scrapie-responsive protein 1", "gene_name": "Scrg1", "organism": "Rat", "refseq_name": "scrapie-responsive protein 1 precursor", "refseq_ac": "NP_277034", "gene_names_uniprotkb": "Scrg1", "gene_names_refseq": "Scrg1", "protein_names_uniprotkb": "Scrapie-responsive protein 1; ScRG-1; Scrapie-responsive gene 1 protein", "protein_names_refseq": "scRG-1; scrapie responsive gene 1; scrapie-responsive gene 1 protein; scrapie-responsive protein 1 precursor; scrapie-responsive protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:64458)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0044306 neuron projection terminus", "go_biological_process": "GO:0097168 mesenchymal stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9Z0K6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1C7-1", "uniprot_id": "RPGF4_RAT", "mass": 50117.0, "length": 436, "protein_name": "Rap guanine nucleotide exchange factor 4", "gene_name": "Rapgef4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rapgef4; Cgef2; Epac2", "gene_names_refseq": "", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 4; EPAC 2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II", "protein_names_refseq": "", "tax_id": 10116, "disease": "autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (R-RNO-354192); (R-RNO-381676); (R-RNO-392517); (R-RNO-422356)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "38843836;9856955", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Does not seem to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0030552 cAMP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0014069 postsynaptic density", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0021510 spinal cord development;GO:1990090 cellular response to nerve growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z1C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2P5-1", "uniprot_id": "RIPK3_RAT", "mass": 52218.0, "length": 478, "protein_name": "Receptor-interacting serine/threonine-protein kinase 3", "gene_name": "Ripk3", "organism": "Rat", "refseq_name": "receptor-interacting serine/threonine-protein kinase 3", "refseq_ac": "NP_647558", "gene_names_uniprotkb": "Ripk3; Rip3", "gene_names_refseq": "Hcyp2; Rip3; Ripk3", "protein_names_uniprotkb": "Receptor-interacting serine/threonine-protein kinase 3; 2.7.11.1; Homocysteine respondent protein HCYP2; RIP-3; RIP-like protein kinase 3; Receptor-interacting protein 3", "protein_names_refseq": "RIP-3; RIP-like protein kinase 3; homocysteine respondent protein HCYP2; receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); adult respiratory distress syndrome (Disease Ontology:DOID:11394)", "pathway": " (rno:246240); (R-RNO-2562578); (R-RNO-3295583); (R-RNO-5213460); (R-RNO-5675482); (R-RNO-937041)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "22673903;29921042;33231560;34772825;35165268;35464769;36424866;37909859", "class_list": "", "function": "RIP3 Contributes to Cardiac Hypertrophy by Influencing MLKL-Mediated Calcium Influx. Publication Status: Online-Only, [RefSeq, PubMed]; RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling., [RefSeq, PubMed]; RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor interacting protein kinase-3 mediates both myopathy and cardiomyopathy in preclinical animal models of Duchenne muscular dystrophy., [RefSeq, PubMed]; Receptor-interacting protein 3-phosphorylated Ca[2+] /calmodulin-dependent protein kinase II and mixed lineage kinase domain-like protein mediate intracerebral hemorrhage-induced neuronal necroptosis., [RefSeq, PubMed]; Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death. Necroptosis, a programmed cell death process in response to death-inducing TNF family members, is triggered by RIPK3 following activation by ZBP1. Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses. In response to flavivirus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate. Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0BMV6", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.3.2.26;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.3.2.23;2.7.11.34;2.7.10.2;3.2.2.-;3.2.2.6;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;2.4.1.255;3.1.3.16;3.6.4.10;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;3.4.22.61;2.3.2.31;2.7.11.10", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097342 ripoptosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001914 regulation of T cell mediated cytotoxicity;GO:0007165 signal transduction;GO:0051353 positive regulation of oxidoreductase activity;GO:0051607 defense response to virus;GO:1990000 amyloid fibril formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z2P5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2Q7-1", "uniprot_id": "STX8_RAT", "mass": 26911.0, "length": 236, "protein_name": "Syntaxin-8", "gene_name": "Stx8", "organism": "Rat", "refseq_name": "syntaxin-8", "refseq_ac": "NP_113844", "gene_names_uniprotkb": "Stx8", "gene_names_refseq": "Stx8", "protein_names_uniprotkb": "Syntaxin-8", "protein_names_refseq": "syntaxin-8; syntaxin-like protein 3I35", "tax_id": 10116, "disease": "", "pathway": " (rno:59074)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10683148;11101518;11786915;15133481;22673903;24659781;24872407", "class_list": "", "function": "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs, [RefSeq, PubMed]; STX8 is a modulator of TrkA cell surface levels and biological functions., [RefSeq, PubMed]; These results suggest that STX8 mediates the recycling of CLDN16 and constitutes an important component of the CLDN16 trafficking machinery in the kidney., [RefSeq, PubMed]; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019869 chloride channel inhibitor activity;GO:0031625 ubiquitin protein ligase binding;GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport;GO:0016192 vesicle-mediated transport;GO:1903076 regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z2Q7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z8Y2-1", "uniprot_id": "DPPA4_RAT", "mass": 32645.0, "length": 297, "protein_name": "Developmental pluripotency-associated protein 4", "gene_name": "Dppa4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dppa4", "gene_names_refseq": "", "protein_names_uniprotkb": "Developmental pluripotency-associated protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic stem (ES) cells into a primitive ectoderm lineage (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048731 system development;GO:0006351 DNA-templated transcription;GO:0010467 gene expression;GO:0060484 lung-associated mesenchyme development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z8Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A096MJZ0-1", "uniprot_id": "DNAL1_RAT", "mass": 21503.0, "length": 190, "protein_name": "Dynein axonemal light chain 1", "gene_name": "Dnal1", "organism": "Rat", "refseq_name": "dynein axonemal light chain 1", "refseq_ac": "NP_001102947", "gene_names_uniprotkb": "Dnal1", "gene_names_refseq": "Dnal1; Dnalc1; LC1", "protein_names_uniprotkb": "Dynein axonemal light chain 1; LC1", "protein_names_refseq": "axonemal dynein light chain 1; dynein axonemal light chain 1; dynein light chain 1, axonemal", "tax_id": 10116, "disease": "primary ciliary dyskinesia 16 (Disease Ontology:DOID:0110613)", "pathway": " (rno:685664)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21496787;22673903", "class_list": "", "function": "Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043014 alpha-tubulin binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005930 axoneme;GO:0030286 dynein complex", "go_biological_process": "GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A096MJZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5DF89-1", "uniprot_id": "CUL3_RAT", "mass": 88932.0, "length": 768, "protein_name": "Cullin-3", "gene_name": "Cul3", "organism": "Rat", "refseq_name": "cullin-3", "refseq_ac": "NP_001100393", "gene_names_uniprotkb": "Cul3", "gene_names_refseq": "Cul3", "protein_names_uniprotkb": "Cullin-3", "protein_names_refseq": "cullin-3", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neurodevelopmental disorder with or without autism or seizures (Disease Ontology:DOID:0061147); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (rno:301555); (R-RNO-4641258); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-8951664); (R-RNO-9013418); (R-RNO-9013422); (R-RNO-9706019); (R-RNO-9755511); (R-RNO-983168); (R-RNO-9929491)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "17062563;34036379;36720302", "class_list": "", "function": "Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4. The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1). The BCR(KLHL25) ubiquitin ligase complex is also involved in lipid synthesis by mediating ubiquitination and degradation of ACLY. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis. The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity. The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry. The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions mediates 'Lys-48' ubiquitination and proteasomal degradation of TIAM1. By controlling the ubiquitination of that RAC1 guanine exchange factors (GEF), regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. The BCR(KBTBD4) E3 ubiquitin ligase complex targets CoREST corepressor complex components RCOR1, KDM1A/LSD1 and HDAC2 for proteasomal degradation with RCOR1 likely to be the primary target while degradation of KDM1A and HDAC2 is likely due to their association with RCOR1 (By similarity). It also targets RCOR3, MIER2 and MIER3 for proteasomal degradation as well as associated proteins ZNF217 and RREB1 with degradation being dependent on the presence of an ELM2 domain in the target proteins (By similarity). The BCR(ARMC5) complex mediates premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation by mediating ubiquitination of Pol II subunit POLR2A (By similarity). Required for 'Lys-63'-linked ubiquitination of large ribosomal subunit protein MRPL12 (By similarity)., [UniProtKB, UniProtKB]; Long noncoding RNA XIST inhibits osteoblast differentiation and promotes osteoporosis via Nrf2 hyperactivation by targeting CUL3., [RefSeq, PubMed]; The Role of Cullin 3 in Cerebral Ischemia-Reperfusion Injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0005112 Notch binding;GO:0061630 ubiquitin protein ligase activity;GO:0031208 POZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1900076 regulation of cellular response to insulin stimulus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B5DF89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0JPQ9-1", "uniprot_id": "CHID1_RAT", "mass": 44875.0, "length": 393, "protein_name": "Chitinase domain-containing protein 1", "gene_name": "Chid1", "organism": "Rat", "refseq_name": "chitinase domain-containing protein 1 isoform 1 precursor", "refseq_ac": "NP_001041319", "gene_names_uniprotkb": "Chid1", "gene_names_refseq": "Cc1-9; Chid1; RGD1308955", "protein_names_uniprotkb": "Chitinase domain-containing protein 1", "protein_names_refseq": "chitinase domain-containing protein 1 isoform 1 precursor; chitinase domain-containing protein 1-like; chitinase domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:293628); (R-RNO-114608)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0008061 chitin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0012505 endomembrane system;GO:0005770 late endosome;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0045087 innate immune response;GO:0005975 carbohydrate metabolic process;GO:1900016 negative regulation of cytokine production involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JPQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2JV04-1", "uniprot_id": "GGA3_RAT", "mass": 78759.0, "length": 727, "protein_name": "ADP-ribosylation factor-binding protein GGA3", "gene_name": "Gga3", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-binding protein GGA3", "refseq_ac": "NP_001402615", "gene_names_uniprotkb": "Gga3", "gene_names_refseq": "Gga3", "protein_names_uniprotkb": "ADP-ribosylation factor-binding protein GGA3; Golgi-localized, gamma ear-containing, ARF-binding protein 3", "protein_names_refseq": "ADP-ribosylation factor-binding protein GGA3; Golgi-localized, gamma ear-containing, ARF-binding protein 3", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (rno:360658); (R-RNO-8875656)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;26446845;29393594", "class_list": "", "function": "Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Involved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation. Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (By similarity). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (PubMed:26446845)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding;GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0055037 recycling endosome;GO:0005764 lysosome;GO:0031901 early endosome membrane", "go_biological_process": "GO:1902430 negative regulation of amyloid-beta formation;GO:0031647 regulation of protein stability;GO:0043001 Golgi to plasma membrane protein transport;GO:0045732 positive regulation of protein catabolic process;GO:0006622 protein targeting to lysosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0G2JV04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0JPQ7-1", "uniprot_id": "CS047_RAT", "mass": 43114.0, "length": 397, "protein_name": "Uncharacterized protein C19orf47 homolog", "gene_name": "C1h19orf47", "organism": "Rat", "refseq_name": "uncharacterized protein C19orf47 homolog isoform 2", "refseq_ac": "NP_001406375", "gene_names_uniprotkb": "C1h19orf47; RGD1307554", "gene_names_refseq": "C1h19orf47; RGD1307554", "protein_names_uniprotkb": "Uncharacterized protein C19orf47 homolog", "protein_names_refseq": "uncharacterized protein C19orf47 homolog isoform 2; uncharacterized protein C19orf47 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:292739)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JPQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1WC58-1", "uniprot_id": "CTIP_RAT", "mass": 100705.0, "length": 893, "protein_name": "DNA endonuclease RBBP8", "gene_name": "Rbbp8", "organism": "Rat", "refseq_name": "DNA endonuclease RBBP8", "refseq_ac": "NP_001127889", "gene_names_uniprotkb": "Rbbp8; Ctip", "gene_names_refseq": "CtIP; RBBP-8; RGD1308872; RIM; Rbbp8; SAE2", "protein_names_uniprotkb": "DNA endonuclease RBBP8; 3.1.-.-; CtBP-interacting protein; CtIP; RBBP-8; RIM; Retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; SAE2; Sporulation in the absence of SPO11 protein 2 homolog", "protein_names_refseq": "DNA endonuclease RBBP8; ctBP-interacting protein; retinoblastoma binding protein 8; sporulation in the absence of SPO11 protein 2 homolog", "tax_id": 10116, "disease": "Seckel syndrome 2 (Disease Ontology:DOID:0070013)", "pathway": " (rno:291787); (R-RNO-5685938); (R-RNO-5685939); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5693568); (R-RNO-5693579); (R-RNO-5693607); (R-RNO-5693616); (R-RNO-6804756); (R-RNO-69473)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (By similarity). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;6.5.1.1;2.7.7.7;3.1.-.-;2.4.2.-;2.7.11.1;5.6.2.4;2.7.7.49;3.6.4.12;5.6.2.1;3.1.11.-;2.3.2.27;2.4.2.30;3.1.22.-;2.7.11.22;3.6.4.-;2.7.11.17;2.4.99.18;2.3.1.48;2.3.1.-;3.6.-.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003684 damaged DNA binding;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0000014 single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0035861 site of double-strand break;GO:0070533 BRCA1-C complex;GO:0005634 nucleus", "go_biological_process": "GO:0051301 cell division;GO:0032355 response to estradiol;GO:0000082 G1/S transition of mitotic cell cycle;GO:0000724 double-strand break repair via homologous recombination;GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WC58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZA12-1", "uniprot_id": "CHD6_RAT", "mass": 303449.0, "length": 2698, "protein_name": "ATP-dependent chromatin remodeler CHD6", "gene_name": "Chd6", "organism": "Rat", "refseq_name": "ATP-dependent chromatin remodeler CHD6 isoform 2", "refseq_ac": "NP_001101267", "gene_names_uniprotkb": "Chd6", "gene_names_refseq": "CHD-6; Chd6", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD6; 3.6.4.-; CHD-6; Chromo domain-containing protein 6", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD6 isoform 2; ATP-dependent chromatin remodeler CHD6; ATP-dependent helicase CHD6; chromo domain-containing protein 6", "tax_id": 10116, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:311607); (R-RNO-9943962)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12189208;22673903;29393594", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.1.4.-;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045454 cell redox homeostasis;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZA12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2K309-1", "uniprot_id": "ORNT1_RAT", "mass": 32797.0, "length": 301, "protein_name": "Mitochondrial ornithine transporter 1", "gene_name": "Slc25a15", "organism": "Rat", "refseq_name": "mitochondrial ornithine transporter 1 isoform X1", "refseq_ac": "XP_006253412", "gene_names_uniprotkb": "Slc25a15", "gene_names_refseq": "Ab1-114; Ornt1; Slc25a15", "protein_names_uniprotkb": "Mitochondrial ornithine transporter 1; Solute carrier family 25 member 15", "protein_names_refseq": "mitochondrial ornithine transporter 1 isoform X1", "tax_id": 10116, "disease": "ornithine translocase deficiency (Disease Ontology:DOID:0050720); amino acid metabolic disorder (Disease Ontology:DOID:9252); citrullinemia (Disease Ontology:DOID:9273)", "pathway": " (R-RNO-70635)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10417335;9359400", "class_list": "", "function": "Mitochondrial ornithine-citrulline antiporter. Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle (PubMed:10417335, PubMed:9359400). Lysine and arginine are also transported by the antiport mechanism (By similarity). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (PubMed:10417335)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000064 L-ornithine transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015189 L-lysine transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1903401 L-lysine transmembrane transport;GO:1990575 mitochondrial L-ornithine transmembrane transport;GO:1903826 L-arginine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2K309-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2K344-1", "uniprot_id": "PK3CA_RAT", "mass": 124354.0, "length": 1068, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "gene_name": "Pik3ca", "organism": "Rat", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "refseq_ac": "NP_596890", "gene_names_uniprotkb": "Pik3ca", "gene_names_refseq": "Pik3ca", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; 2.7.1.137; 2.7.1.153; 2.7.11.1; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; PtdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA; p110alpha", "protein_names_refseq": "PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; p110alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase catalytic alpha polypeptide; ptdIns-3-kinase subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA", "tax_id": 10116, "disease": "estrogen-receptor positive breast cancer (Disease Ontology:DOID:0060075); cerebral cavernous malformation (Disease Ontology:DOID:0060669); colorectal carcinoma (Disease Ontology:DOID:0080199); CLOVES syndrome (Disease Ontology:DOID:0080351); Cowden syndrome 5 (Disease Ontology:DOID:0081001); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); epidermal nevus (Disease Ontology:DOID:0111162); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); rectal benign neoplasm (Disease Ontology:DOID:1984); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); cutaneous Paget's disease (Disease Ontology:DOID:3450); breast angiosarcoma (Disease Ontology:DOID:4511); esophageal cancer (Disease Ontology:DOID:5041); seborrheic keratosis (Disease Ontology:DOID:6498); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:170911); (R-RNO-109704); (R-RNO-112399); (R-RNO-114604); (R-RNO-1250342); (R-RNO-1257604); (R-RNO-1433557); (R-RNO-1660499); (R-RNO-180292); (R-RNO-186763); (R-RNO-1963642); (R-RNO-198203); (R-RNO-201556); (R-RNO-202424); (R-RNO-2029485); (R-RNO-210993); (R-RNO-2424491); (R-RNO-2730905); (R-RNO-389357); (R-RNO-416476); (R-RNO-4420097); (R-RNO-512988); (R-RNO-5654689); (R-RNO-5654695); (R-RNO-5654710); (R-RNO-5654720); (R-RNO-5673001); (R-RNO-6811558); (R-RNO-8851907); (R-RNO-8853659); (R-RNO-9009391); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9027276); (R-RNO-912526); (R-RNO-912631); (R-RNO-9607240); (R-RNO-9842663); (R-RNO-9927354)", "pathway_count": 39, "publication_count": 3, "publication_id_list": "12220227;20236230;34129205", "class_list": "", "function": "Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression., [RefSeq, PubMed]; PI 3-kinase feedback control of signalling by the insulin receptor and IRS proteins is multifaceted and reciprocal, [RefSeq, PubMed]; Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins (PubMed:20236230). Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (By similarity). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.10.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.3.2.27;2.7.12.2;2.7.10.2;2.7.11.12;2.7.11.26;2.7.11.21;2.7.11.34;2.7.1.150;2.7.11.13;3.6.5.2;2.7.7.49;2.7.11.19;2.7.2.3;2.7.11.11;3.1.3.48;2.7.11.31;3.1.3.16;3.1.4.4;3.6.5.-;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;3.2.2.6;2.7.11.39;1.6.3.-;2.4.99.18;2.7.-.-;2.7.1.151;2.7.1.140;2.7.11.10;3.2.1.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030295 protein kinase activator activity;GO:0043560 insulin receptor substrate binding;GO:0016303 1-phosphatidylinositol-3-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0014704 intercalated disc", "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization;GO:0043457 regulation of cellular respiration;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0086003 cardiac muscle cell contraction;GO:0014870 response to muscle inactivity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0G2K344-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5DF27-1", "uniprot_id": "LOXL2_RAT", "mass": 87185.0, "length": 776, "protein_name": "Lysyl oxidase homolog 2", "gene_name": "Loxl2", "organism": "Rat", "refseq_name": "lysyl oxidase homolog 2 precursor", "refseq_ac": "NP_001099517", "gene_names_uniprotkb": "Loxl2", "gene_names_refseq": "Loxl2", "protein_names_uniprotkb": "Lysyl oxidase homolog 2; 1.4.3.13; Lysyl oxidase-like protein 2", "protein_names_refseq": "lysyl oxidase homolog 2 precursor; lysyl oxidase homolog 2; lysyl oxidase-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:290350); (R-RNO-1566948); (R-RNO-2243919)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21835952;29966587;34426599", "class_list": "", "function": "Dual inhibition of LOXL2 and LOXL3 in a pulmonary fibrosis model was sufficient to normalize collagen fibrillogenesis, reduce tissue stiffness, and improve lung function in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; LOXL2 attenuates osteoarthritis through inactivating Integrin/FAK signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "F1LPM2", "ec_number_list": "1.4.3.13;3.4.24.-", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0005509 calcium ion binding;GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0036211 protein modification process;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B5DF27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2K6Z9-1", "uniprot_id": "ODAPH_RAT", "mass": 14833.0, "length": 127, "protein_name": "Odontogenesis-associated phosphoprotein", "gene_name": "Odaph", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Odaph", "gene_names_refseq": "", "protein_names_uniprotkb": "Odontogenesis-associated phosphoprotein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22901946", "class_list": "", "function": "May promote nucleation of hydroxyapatite., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0070169 positive regulation of biomineral tissue development;GO:0070175 positive regulation of enamel mineralization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K6Z9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0JPJ7-1", "uniprot_id": "OLA1_RAT", "mass": 44535.0, "length": 396, "protein_name": "Obg-like ATPase 1", "gene_name": "Ola1", "organism": "Rat", "refseq_name": "obg-like ATPase 1", "refseq_ac": "NP_001029099", "gene_names_uniprotkb": "Ola1; OLA1", "gene_names_refseq": "Ola1; PTD004; RGD1307982", "protein_names_uniprotkb": "Obg-like ATPase 1", "protein_names_refseq": "GTP-binding protein PTD004; obg-like ATPase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:296488); (R-RNO-114608)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046034 ATP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JPJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0JPP1-1", "uniprot_id": "NC2A_RAT", "mass": 22326.0, "length": 205, "protein_name": "Dr1-associated corepressor", "gene_name": "Drap1", "organism": "Rat", "refseq_name": "dr1-associated corepressor", "refseq_ac": "NP_001071136", "gene_names_uniprotkb": "Drap1", "gene_names_refseq": "Drap1", "protein_names_uniprotkb": "Dr1-associated corepressor; Dr1-associated protein 1; NC2-alpha; Negative cofactor 2-alpha", "protein_names_refseq": "Dr1 associated protein 1 (negative cofactor 2 alpha); NC2-alpha; dr1-associated corepressor; dr1-associated protein 1; negative co-factor 2-alpha; negative cofactor 2-alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:293674)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0003714 transcription corepressor activity;GO:0017025 TBP-class protein binding;GO:0001046 core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex;GO:0017054 negative cofactor 2 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JPP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1L1J9-1", "uniprot_id": "LMF2_RAT", "mass": 80254.0, "length": 702, "protein_name": "Lipase maturation factor 2", "gene_name": "Lmf2", "organism": "Rat", "refseq_name": "lipase maturation factor 2", "refseq_ac": "NP_001073408", "gene_names_uniprotkb": "Lmf2", "gene_names_refseq": "Lmf2; RGD1306274; Tmem112b", "protein_names_uniprotkb": "Lipase maturation factor 2", "protein_names_refseq": "lipase maturation factor 2; transmembrane protein 112B", "tax_id": 10116, "disease": "", "pathway": " (rno:315218); (R-RNO-8963889)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0G9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L1J9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A4GG66-1", "uniprot_id": "CXG1_RAT", "mass": 45666.0, "length": 396, "protein_name": "Gap junction gamma-1 protein", "gene_name": "Gjc1", "organism": "Rat", "refseq_name": "gap junction gamma-1 protein", "refseq_ac": "NP_001078850", "gene_names_uniprotkb": "Gjc1; Gja7", "gene_names_refseq": "Cx45; Cxnq; Gja7; Gjc1", "protein_names_uniprotkb": "Gap junction gamma-1 protein; Connexin-45; Cx45; Gap junction alpha-7 protein", "protein_names_refseq": "connexin q; connexin-45; gap junction alpha-7 protein; gap junction channel protein connexin 45; gap junction gamma-1 protein; gap junction membrane channel protein alpha 7", "tax_id": 10116, "disease": "", "pathway": " (rno:266706); (R-RNO-112303); (R-RNO-190861)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12011467;12064590;17328669;24043768;24883012;27913256;28561933;34808525", "class_list": "", "function": "Changes in connexins, including Cx36, Cx43, and Cx45, may contribute to the damage process. Publication Status: Online-Only, [RefSeq, PubMed]; Cx45-puncta in the cerebellar molecular layer were co-localized with Cx36-puncta and additionally occurred along Bergmann glial processes adjacent to Cx43-puncta. Expression of both Cx43 and Cx45 in Bergmann glia of rat may contribute to the complex properties of junctional coupling between these cells and perhaps to their reported coupling with Purkinje cells., [RefSeq, PubMed]; Data suggests that connexin 45 and ZO-1 directly interact in osteoblastic cells (ROS/Cx45) [ZO-1], [RefSeq, PubMed]; Sex-specific effects of metformin and liraglutide on renal pathology and expression of connexin 45 and pannexin 1 following long-term high-fat high-sugar diet., [RefSeq, PubMed]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (PubMed:12011467). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (By similarity)., [UniProtKB, PubMed, UniProtKB]; The absence of Cx43/Cx45 hemichannels in skeltal muscles cells greatly attenuates the inflammasome activation and muscle atrophy., [RefSeq, PubMed]; The results of the present study revealed that during memory consolidation in a passive avoidance paradigm, a rapid upregulation of Cx45 mRNAs level occurs in the hippocampus, which declines to the control level by 24 h after training., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0001570 vasculogenesis;GO:0007267 cell-cell signaling;GO:0007507 heart development;GO:0045087 innate immune response;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A4GG66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A4L691-1", "uniprot_id": "PINX1_RAT", "mass": 36710.0, "length": 331, "protein_name": "PIN2/TERF1-interacting telomerase inhibitor 1", "gene_name": "Pinx1", "organism": "Rat", "refseq_name": "PIN2/TERF1-interacting telomerase inhibitor 1", "refseq_ac": "NP_001076806", "gene_names_uniprotkb": "Pinx1", "gene_names_refseq": "Pinx1; RGD1566025", "protein_names_uniprotkb": "PIN2/TERF1-interacting telomerase inhibitor 1; Pin2-interacting protein X1", "protein_names_refseq": "PIN2-interacting protein 1; PIN2/TERF1-interacting telomerase inhibitor 1; Pin2-interacting protein X1", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:305963)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17624691;22673903;33819185", "class_list": "", "function": "Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity)., [UniProtKB, PubMed]; Regulation of PINX1 expression ameliorates lipopolysaccharide-induced lung injury and alleviates cell senescence during the convalescent phase through affecting the telomerase activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0070034 telomerase RNA binding;GO:0010521 telomerase inhibitor activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005819 spindle;GO:0000776 kinetochore;GO:0000228 nuclear chromosome", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0070198 protein localization to chromosome, telomeric region;GO:0031647 regulation of protein stability;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A4L691-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7E3N7-1", "uniprot_id": "NOXA1_RAT", "mass": 49245.0, "length": 446, "protein_name": "NADPH oxidase activator 1", "gene_name": "Noxa1", "organism": "Rat", "refseq_name": "NADPH oxidase activator 1", "refseq_ac": "NP_001093641", "gene_names_uniprotkb": "Noxa1", "gene_names_refseq": "Noxa1", "protein_names_uniprotkb": "NADPH oxidase activator 1", "protein_names_refseq": "NADPH oxidase activator 1; predicted NADPH oxidase activator 1", "tax_id": 10116, "disease": "", "pathway": " (rno:311793); (R-RNO-5668599); (R-RNO-9013149); (R-RNO-9013423)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "15326186;17612411;25228390", "class_list": "", "function": "Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0016176 superoxide-generating NADPH oxidase activator activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006801 superoxide metabolic process;GO:0042554 superoxide anion generation;GO:0010310 regulation of hydrogen peroxide metabolic process;GO:0060263 regulation of respiratory burst", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A7E3N7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BLS0-1", "uniprot_id": "OST4_RAT", "mass": 4193.0, "length": 37, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4", "gene_name": "Ost4", "organism": "Rat", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4", "refseq_ac": "NP_001128162", "gene_names_uniprotkb": "Ost4", "gene_names_refseq": "Ost4", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4; oligosaccharyltransferase 4 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:100188932); (R-RNO-9768727); (R-RNO-9931295)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A;GO:0160227 oligosaccharyltransferase complex B", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BLS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BNI5-1", "uniprot_id": "OLFL3_RAT", "mass": 45961.0, "length": 406, "protein_name": "Olfactomedin-like protein 3", "gene_name": "Olfml3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Olfml3", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactomedin-like protein 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:310743)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0K011-1", "uniprot_id": "OSR1_RAT", "mass": 29584.0, "length": 266, "protein_name": "Protein odd-skipped-related 1", "gene_name": "Osr1", "organism": "Rat", "refseq_name": "protein odd-skipped-related 1", "refseq_ac": "NP_001100186", "gene_names_uniprotkb": "Osr1; Odd1", "gene_names_refseq": "Odd1; Osr1", "protein_names_uniprotkb": "Protein odd-skipped-related 1", "protein_names_refseq": "odd-skipped related 1; odd-skipped related transciption factor 1; protein odd-skipped-related 1", "tax_id": 10116, "disease": "", "pathway": " (rno:298878)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22238094", "class_list": "", "function": "SPAK and OSR1 may be critical factors in the regulation of depolarizing GABA-mediated processes in the developing brain., [RefSeq, PubMed]; Transcription factor that plays a role in the regulation of embryonic heart and urogenital development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0034763 negative regulation of transmembrane transport;GO:0072180 mesonephric duct morphogenesis;GO:0048389 intermediate mesoderm development;GO:0072111 cell proliferation involved in kidney development;GO:0072143 mesangial cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0K011-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0K025-1", "uniprot_id": "OSTC_RAT", "mass": 16815.0, "length": 149, "protein_name": "Oligosaccharyltransferase complex subunit OSTC", "gene_name": "Ostc", "organism": "Rat", "refseq_name": "oligosaccharyltransferase complex subunit OSTC", "refseq_ac": "NP_001102036", "gene_names_uniprotkb": "Ostc; Dc2", "gene_names_refseq": "Dc2; Ostc; RGD1560708", "protein_names_uniprotkb": "Oligosaccharyltransferase complex subunit OSTC", "protein_names_refseq": "oligosaccharyltransferase complex subunit (non-catalytic); oligosaccharyltransferase complex subunit OSTC", "tax_id": 10116, "disease": "", "pathway": " (rno:362040); (R-RNO-9768727); (R-RNO-9931295)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0K025-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1H283-1", "uniprot_id": "CMAP2_RAT", "mass": 45835.0, "length": 402, "protein_name": "Ciliary microtubule-associated protein 2", "gene_name": "Cimap2", "organism": "Rat", "refseq_name": "ciliary microtubule-associated protein 2", "refseq_ac": "NP_001102732", "gene_names_uniprotkb": "Cimap2; Lexm", "gene_names_refseq": "Cimap2; Lexm; RGD1559493", "protein_names_uniprotkb": "Ciliary microtubule-associated protein 2; Lymphocyte expansion molecule", "protein_names_refseq": "ciliary microtubule-associated protein 2; lymphocyte expansion molecule; uncharacterized protein C1orf177 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500516)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1H283-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1WBU8-1", "uniprot_id": "PLHD1_RAT", "mass": 59055.0, "length": 505, "protein_name": "Pleckstrin homology domain-containing family D member 1", "gene_name": "Plekhd1", "organism": "Rat", "refseq_name": "pleckstrin homology domain-containing family D member 1", "refseq_ac": "NP_001121038", "gene_names_uniprotkb": "Plekhd1", "gene_names_refseq": "Plekhd1; RGD1566112", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family D member 1; PH domain-containing family D member 1", "protein_names_refseq": "PH domain-containing family D member 1; UPF0639 protein; pleckstrin homology domain containing, family D (with M protein repeats) member 1; pleckstrin homology domain containing, family D (with coiled-coil domains) member 1; pleckstrin homology domain-containing family D member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:500685)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WBU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1WBV0-1", "uniprot_id": "CTU1_RAT", "mass": 40242.0, "length": 382, "protein_name": "Cytoplasmic tRNA 2-thiolation protein 1", "gene_name": "Ctu1", "organism": "Rat", "refseq_name": "cytoplasmic tRNA 2-thiolation protein 1", "refseq_ac": "NP_001099721", "gene_names_uniprotkb": "Ctu1; Atpbd3; Ncs6", "gene_names_refseq": "Atpbd3; Ctu1; RGD1308740", "protein_names_uniprotkb": "Cytoplasmic tRNA 2-thiolation protein 1; 2.7.7.-; ATP-binding domain-containing protein 3; Cytoplasmic tRNA adenylyltransferase 1", "protein_names_refseq": "ATP binding domain 3; ATP-binding domain-containing protein 3; cytoplasmic tRNA 2-thiolation protein 1; cytoplasmic tRNA adenylyltransferase 1; cytosolic thiouridylase subunit 1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:292847)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000049 tRNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0002144 cytosolic tRNA wobble base thiouridylase complex", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WBV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1WCA1-1", "uniprot_id": "B1WCA1_RAT", "mass": 55240.0, "length": 499, "protein_name": "Fizzy-related protein homolog", "gene_name": "Fzr1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fzr1", "gene_names_refseq": "", "protein_names_uniprotkb": "Fizzy-related protein homolog; Cdh1/Hct1 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 109 (Disease Ontology:DOID:0070378); disease of cellular proliferation (Disease Ontology:DOID:14566)", "pathway": " (rno:314642); (R-RNO-174084); (R-RNO-174113); (R-RNO-174178); (R-RNO-176407); (R-RNO-176408); (R-RNO-176417); (R-RNO-2559582); (R-RNO-68867); (R-RNO-69017); (R-RNO-69273); (R-RNO-69656); (R-RNO-983168)", "pathway_count": 13, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0010997 anaphase-promoting complex binding;GO:1990757 ubiquitin ligase activator activity;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:2000773 negative regulation of cellular senescence;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:1904668 positive regulation of ubiquitin protein ligase activity;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1WCA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2GUY1-1", "uniprot_id": "PLK4_RAT", "mass": 103770.0, "length": 924, "protein_name": "Serine/threonine-protein kinase PLK4", "gene_name": "Plk4", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase PLK4", "refseq_ac": "NP_001382032", "gene_names_uniprotkb": "Plk4; Sak", "gene_names_refseq": "Plk4", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK4; 2.7.11.21; PLK-4; Polo-like kinase 4; Serine/threonine-protein kinase Sak", "protein_names_refseq": "PLK-4; serine/threonine-protein kinase PLK4; serine/threonine-protein kinase Sak", "tax_id": 10116, "disease": "ciliopathy (Disease Ontology:DOID:0060340); microcephaly and chorioretinopathy 2 (Disease Ontology:DOID:0080106); colon cancer (Disease Ontology:DOID:219); breast ductal carcinoma (Disease Ontology:DOID:3007); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (rno:310344); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-8854518)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "33416109;37914064", "class_list": "", "function": "MicroRNA126 suppresses the proliferation and migration of endothelial cells in experimental diabetic retinopathy by targeting pololike kinase 4., [RefSeq, PubMed]; NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell proliferation by TLR4/NF-kappaB/PLK4 signaling pathway., [RefSeq, PubMed]; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity). Phosphorylates CEP131 and PCM1 which is essential for proper organization and integrity of centriolar satellites (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;3.6.5.2;2.7.11.31;3.1.3.16;3.6.5.-;3.6.4.10;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0032154 cleavage furrow;GO:0005814 centriole", "go_biological_process": "GO:0046601 positive regulation of centriole replication;GO:0006468 protein phosphorylation;GO:0060271 cilium assembly;GO:0060707 trophoblast giant cell differentiation;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B2GUY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2GV46-1", "uniprot_id": "FFAR3_RAT", "mass": 36483.0, "length": 319, "protein_name": "Free fatty acid receptor 3", "gene_name": "Ffar3", "organism": "Rat", "refseq_name": "free fatty acid receptor 3", "refseq_ac": "NP_001102382", "gene_names_uniprotkb": "Ffar3; Gpr41", "gene_names_refseq": "Ffar3; Gpr41", "protein_names_uniprotkb": "Free fatty acid receptor 3; G protein-coupled receptor 41", "protein_names_refseq": "G protein-coupled receptor 41; free fatty acid receptor 3", "tax_id": 10116, "disease": "", "pathway": " (rno:365228); (R-RNO-416476); (R-RNO-444209)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12496283;24305827;24412651;26854275;28714277;29393594;34216575", "class_list": "", "function": "G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases (PubMed:24305827). Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis (PubMed:24412651). May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells., [UniProtKB, PubMed, PubMed, PubMed]; Short-chain fatty acid receptors involved in epithelial acetylcholine release in rat caecum., [RefSeq, PubMed]; Study demonstrates that free fatty acid receptor 3 activation inhibited nicotine-evoked neural activity in the regulation of colonic motility., [RefSeq, PubMed]; These results suggest that the short-chain fatty acid-FFA3 pathway has a novel anti-secretory function in that it inhibits cholinergic neural reflexes in the enteric nervous system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0014061 regulation of norepinephrine secretion;GO:0032722 positive regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B2GV46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RYG6-1", "uniprot_id": "OTUB1_RAT", "mass": 31270.0, "length": 271, "protein_name": "Ubiquitin thioesterase OTUB1", "gene_name": "Otub1l1; Otub1", "organism": "Rat", "refseq_name": "ubiquitin thioesterase OTUB1", "refseq_ac": "NP_001099802", "gene_names_uniprotkb": "Otub1l1; Otub1; AABR07056013.1; Otub1l1; RGD1565010", "gene_names_refseq": "Otub1", "protein_names_uniprotkb": "Ubiquitin thioesterase OTUB1; 3.4.19.12; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Otubain-1; Ubiquitin-specific-processing protease OTUB1", "protein_names_refseq": "OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; deubiquitinating enzyme OTUB1; otubain-1; ubiquitin thioesterase OTUB1; ubiquitin-specific-processing protease OTUB1", "tax_id": 10116, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); IgA glomerulonephritis (Disease Ontology:DOID:2986)", "pathway": " (rno:293705); (rno:314660); (R-RNO-5689880); (R-RNO-5689896)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "18683930;19343716;22279542;27629786", "class_list": "", "function": "Data show that the overexpression of OTUB1 enhanced the ubiquitination and degradation of Decorin (DCN)in mesangial cells (MC)., [RefSeq, PubMed]; Hydrolase that can specifically remove compared to 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (By similarity). Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen (By similarity). Acts via its interaction with RNF128/GRAIL (By similarity). Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128 (By similarity). Deubiquitinates estrogen receptor alpha (ESR1) (By similarity). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains (By similarity). Not able to cleave di-ubiquitin (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; OTUB1 may play a role in protecting the brain from secondary damage following intracerebral hemorrhage., [RefSeq, PubMed]; Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites. Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of 'Lys-63'-linked histone H2A and H2AX marks. Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1. The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain. Acts as a regulator of mTORC1 and mTORC2 complexes. When phosphorylated at Tyr-26, acts as an activator of the mTORC1 complex by mediating deubiquitination of RPTOR via a non-catalytic process: acts by binding and inhibiting the activity of the ubiquitin-conjugating enzyme E2 (UBE2D1/UBCH5A, UBE2W/UBC16 and UBE2N/UBC13), thereby preventing ubiquitination of RPTOR. Can also act as an inhibitor of the mTORC1 and mTORC2 complexes in response to amino acids by mediating non-catalytic deubiquitination of DEPTOR., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;3.4.19.12;2.3.2.24;2.3.2.23;3.6.5.2", "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0031625 ubiquitin protein ligase binding;GO:0043130 ubiquitin binding;GO:0055105 ubiquitin-protein transferase inhibitor activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:2000780 negative regulation of double-strand break repair;GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B2RYG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B3DMA0-1", "uniprot_id": "P5I11_RAT", "mass": 20939.0, "length": 189, "protein_name": "Tumor protein p53-inducible protein 11", "gene_name": "Tp53i11", "organism": "Rat", "refseq_name": "tumor protein p53-inducible protein 11", "refseq_ac": "NP_001101219", "gene_names_uniprotkb": "Tp53i11; Pig11", "gene_names_refseq": "Tp53i11; Trp53i11", "protein_names_uniprotkb": "Tumor protein p53-inducible protein 11; p53-induced gene 11 protein", "protein_names_refseq": "p53-induced gene 11 protein; transformation related protein 53 inducible protein 11; tumor protein p53-inducible protein 11", "tax_id": 10116, "disease": "", "pathway": " (rno:311209)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B3DMA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B4F779-1", "uniprot_id": "DP13B_RAT", "mass": 74117.0, "length": 662, "protein_name": "DCC-interacting protein 13-beta", "gene_name": "Appl2", "organism": "Rat", "refseq_name": "DCC-interacting protein 13-beta", "refseq_ac": "NP_001102211", "gene_names_uniprotkb": "Appl2", "gene_names_refseq": "Appl2; RGD1563028", "protein_names_uniprotkb": "DCC-interacting protein 13-beta; Adapter protein containing PH domain, PTB domain and leucine zipper motif 2", "protein_names_refseq": "DCC-interacting protein 13-beta; adapter protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2", "tax_id": 10116, "disease": "", "pathway": " (rno:362860)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29393594;30189216", "class_list": "", "function": "Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (By similarity). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways and adaptative thermogenesis (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oyidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negatively regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (By similarity). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (By similarity). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0001786 phosphatidylserine binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0046322 negative regulation of fatty acid oxidation;GO:0051289 protein homotetramerization;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B4F779-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5D5N9-1", "uniprot_id": "CTR2_RAT", "mass": 71694.0, "length": 657, "protein_name": "Cationic amino acid transporter 2", "gene_name": "Slc7a2", "organism": "Rat", "refseq_name": "cationic amino acid transporter 2 isoform b", "refseq_ac": "NP_001128158", "gene_names_uniprotkb": "Slc7a2; Atrc2; Cat2", "gene_names_refseq": "Cat2a; Cat2b; Cat2; Slc7a2", "protein_names_uniprotkb": "Cationic amino acid transporter 2; CAT-2; CAT2; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2", "protein_names_refseq": "CAT-2; cationic amino acid transporter 2 isoform b; cationic amino acid transporter-2A; low affinity cationic amino acid transporter 2; solute carrier family 7 (cationic amino acid transporter, y+ system), member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:64554)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18028947;19386725;21454685;22673903", "class_list": "", "function": "CAT1, CAT2, DDAH2, and arginase-1 expression in renal resistance vessels is regulated through the AT(1) receptor., [RefSeq, PubMed]; Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). The affinity for its substrates differs between isoforms created by alternative splicing (By similarity). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; HO-1 overexpression significantly attenuates endotoxin-induced increases in nitric oxide and l-arginine transport, as well as the expression of iNOS and CAT-2 isozymes in septic rats., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B5D5P0", "ec_number_list": "", "go_molecular_function": "GO:0000064 L-ornithine transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0005289 high-affinity L-arginine transmembrane transporter activity;GO:0005292 high-affinity lysine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:0050727 regulation of inflammatory response;GO:1902475 L-alpha-amino acid transmembrane transport;GO:0006809 nitric oxide biosynthetic process;GO:0002537 nitric oxide production involved in inflammatory response;GO:0043030 regulation of macrophage activation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B5D5N9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5DF91-1", "uniprot_id": "ELAV1_RAT", "mass": 36169.0, "length": 326, "protein_name": "ELAV-like protein 1", "gene_name": "Elavl1", "organism": "Rat", "refseq_name": "ELAV-like protein 1", "refseq_ac": "NP_001102318", "gene_names_uniprotkb": "Elavl1; Hur", "gene_names_refseq": "Elavl1; HuR; Hua", "protein_names_uniprotkb": "ELAV-like protein 1; Hu-antigen R; HuR", "protein_names_refseq": "ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV like 1; ELAV-like protein 1; hu-antigen R; mRNA-stabilizing factor HuR", "tax_id": 10116, "disease": "degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (rno:363854); (R-RNO-450520)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12234802;12832476;12876290;18161049;22673903;34788763;36173508;37164303;37713069;38342180", "class_list": "", "function": "Downregulation of ELAVL1 attenuates ferroptosis-induced neuronal impairment in rats with cerebral ischemia/reperfusion via reducing DNMT3B-dependent PINK1 methylation., [RefSeq, PubMed]; HPF1 regulates tendon stem/progenitor cell senescence and tendon repair via PARP1-mediated poly-ADP ribosylation of HuR., [RefSeq, PubMed]; Hu protein R-mediated posttranscriptional regulation of VEGF expression in rat gastrocnemius muscle., [RefSeq, PubMed]; Increased binding of HuR to the TNFalpha 3'-UTR contributes to increased LPS-stimulated TNFalpha expression in macrophages after chronic ethanol exposure, [RefSeq, PubMed]; MicroRNA-9a-5p disrupts the ELAVL1/VEGF axis to alleviate traumatic brain injury., [RefSeq, PubMed]; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (By similarity). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The RNA Binding Protein HuR Promotes Neuronal Apoptosis in Rats with Spinal Cord Injury via the HDAC1/RAD21 Axis., [RefSeq, PubMed]; These results demonstrate that NO acts in a cGMP-dependent mechanism to inhibit the expression level of HuR, thereby reducing the stability of MMP-9 mRNA, [RefSeq, PubMed]; Trimethylamine-N-Oxide Aggravates Kidney Injury via Activation of p38/MAPK Signaling and Upregulation of HuR., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060965 negative regulation of miRNA-mediated gene silencing;GO:0008283 cell population proliferation;GO:0032930 positive regulation of superoxide anion generation;GO:0048255 mRNA stabilization;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "B5DF91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5DFM7-1", "uniprot_id": "CTSRD_RAT", "mass": 91436.0, "length": 803, "protein_name": "Cation channel sperm-associated auxiliary subunit delta", "gene_name": "Catsperd", "organism": "Rat", "refseq_name": "cation channel sperm-associated auxiliary subunit delta isoform 4 precursor", "refseq_ac": "NP_001128456", "gene_names_uniprotkb": "Catsperd; Tmem146", "gene_names_refseq": "Catsperd; Tmem146", "protein_names_uniprotkb": "Cation channel sperm-associated auxiliary subunit delta; CatSper-delta; CatSperdelta; Transmembrane protein 146", "protein_names_refseq": "catSper-delta; catSperdelta; cation channel sperm associated auxiliary subunit delta; cation channel sperm-associated auxiliary subunit delta isoform 4 precursor; cation channel sperm-associated protein subunit delta; transmembrane protein 146", "tax_id": 10116, "disease": "", "pathway": " (rno:680264); (R-RNO-1300642)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A0A0H2UI41", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036128 CatSper complex;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DFM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B7SUM8-1", "uniprot_id": "FBP12_RAT", "mass": 14860.0, "length": 132, "protein_name": "Fatty acid-binding protein 12", "gene_name": "FABP12; Fabp12", "organism": "Rat", "refseq_name": "fatty acid-binding protein 12", "refseq_ac": "NP_001128086", "gene_names_uniprotkb": "FABP12; Fabp12", "gene_names_refseq": "Fabp12; RGD1565000", "protein_names_uniprotkb": "Fatty acid-binding protein 12", "protein_names_refseq": "fatty acid-binding protein 12; intracellular fatty acid-binding protein FABP12", "tax_id": 10116, "disease": "", "pathway": " (rno:499570); (R-RNO-163560)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18786628", "class_list": "", "function": "FABP12 arose as the result of tandem gene duplication, a mechanism that may have been instrumental to the expansion of the FABP family., [RefSeq, PubMed]; May play a role in lipid transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B7SUM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D2XV59-1", "uniprot_id": "GTPB1_RAT", "mass": 72489.0, "length": 669, "protein_name": "GTP-binding protein 1", "gene_name": "Gtpbp1", "organism": "Rat", "refseq_name": "GTP-binding protein 1", "refseq_ac": "NP_001186244", "gene_names_uniprotkb": "Gtpbp1", "gene_names_refseq": "Gtpbp1", "protein_names_uniprotkb": "GTP-binding protein 1; 3.6.5.3", "protein_names_refseq": "GTP-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:300077)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21515746;22673903", "class_list": "", "function": "GTPase that plays a role in the elongation phase of protein synthesis by forming ternary complexes with GTP and aminoacyl-transfer RNAs (aa-tRNAs), and delivering aa-tRNAs to the ribosomal A site in a GTP-dependent manner. Is also able to deliver deacylated tRNA to the A site. Additionally, it is involved in RNA quality control; after GTP hydrolysis, which is not immediately followed by rapid peptide bond formation, GTPBP1 likely retains aa-tRNA in the A site and promotes exosomal degradation of faulty mRNAs engaged in 80S elongation complexes (By similarity). Plays a role in the regulation of circadian mRNA stability., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0000049 tRNA binding;GO:0003746 translation elongation factor activity;GO:1904678 alpha-aminoacyl-tRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0000177 cytoplasmic exosome (RNase complex);GO:0005737 cytoplasm", "go_biological_process": "GO:0071025 RNA surveillance;GO:0046039 GTP metabolic process;GO:0061014 positive regulation of mRNA catabolic process;GO:0006414 translational elongation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D2XV59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZB94-1", "uniprot_id": "GFRAL_RAT", "mass": 43946.0, "length": 394, "protein_name": "GDNF family receptor alpha-like", "gene_name": "Gfral", "organism": "Rat", "refseq_name": "GDNF family receptor alpha-like isoform 3 precursor", "refseq_ac": "NP_001178927", "gene_names_uniprotkb": "Gfral", "gene_names_refseq": "Gfral; RGD1565220", "protein_names_uniprotkb": "GDNF family receptor alpha-like", "protein_names_refseq": "GDNF family receptor alpha-like isoform 3 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:501023)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "28846097;28846098;28846099;31928886;37060902;38064571", "class_list": "", "function": "Acute Activation of GFRAL in the Area Postrema Contributes to Glucose Regulation Independent of Weight., [RefSeq, PubMed]; Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846098, PubMed:28846099, PubMed:31928886, PubMed:37060902). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (By similarity). The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin (PubMed:37060902). Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways (By similarity). Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (By similarity). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0030971 receptor tyrosine kinase binding;GO:0038023 signaling receptor activity;GO:0016167 glial cell-derived neurotrophic factor receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0043524 negative regulation of neuron apoptotic process;GO:0031098 stress-activated protein kinase signaling cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3ZB94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62024-1", "uniprot_id": "PHAR1_RAT", "mass": 66216.0, "length": 580, "protein_name": "Phosphatase and actin regulator 1", "gene_name": "Phactr1", "organism": "Rat", "refseq_name": "phosphatase and actin regulator 1 isoform 7", "refseq_ac": "NP_999622", "gene_names_uniprotkb": "Phactr1; AABR07027306.1", "gene_names_refseq": "Phactr1", "protein_names_uniprotkb": "Phosphatase and actin regulator 1", "protein_names_refseq": "phosphatase and actin regulator 1 isoform 7", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); developmental and epileptic encephalopathy 70 (Disease Ontology:DOID:0112206); essential hypertension (Disease Ontology:DOID:10825); Moyamoya disease (Disease Ontology:DOID:13099); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); coronary stenosis (Disease Ontology:DOID:4248); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364)", "pathway": " (rno:306844)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15107502", "class_list": "", "function": "Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (By similarity). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KMC2", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008157 protein phosphatase 1 binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0098794 postsynapse", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0021987 cerebral cortex development;GO:0140059 dendrite arborization;GO:0030036 actin cytoskeleton organization;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70470-1", "uniprot_id": "LYPA1_RAT", "mass": 24709.0, "length": 230, "protein_name": "Acyl-protein thioesterase 1", "gene_name": "Lypla1", "organism": "Rat", "refseq_name": "acyl-protein thioesterase 1 isoform 2", "refseq_ac": "NP_037138", "gene_names_uniprotkb": "Lypla1; Apt1", "gene_names_refseq": "25KDL; APT-1; LPL-I; Lypla1; Pla1a; lysoPLA", "protein_names_uniprotkb": "Acyl-protein thioesterase 1; 3.1.2.-; 3.1.2.22; APT-1; LPL-I; LysoPLA I; Lysophospholipase 1; Lysophospholipase I; Palmitoyl-protein hydrolase", "protein_names_refseq": "acyl-protein thioesterase 1 isoform 2; acyl-protein thioesterase 1; lysoPLA I; lysophospholipase I; palmitoyl-protein hydrolase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); pervasive developmental disorder (Disease Ontology:DOID:0060040); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); antisocial personality disorder (Disease Ontology:DOID:10939); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); opioid abuse (Disease Ontology:DOID:11206); pathological gambling (Disease Ontology:DOID:12399); conduct disorder (Disease Ontology:DOID:12995); alcohol use disorder (Disease Ontology:DOID:1574); substance abuse (Disease Ontology:DOID:302); dyslexia (Disease Ontology:DOID:4428); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); cannabis abuse (Disease Ontology:DOID:9505); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25514); (R-RNO-203615); (R-RNO-9648002)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12361707;8631810;9624183;9644627", "class_list": "", "function": "Activity in eosinophil leukocytes, [RefSeq, PubMed]; Acts as an acyl-protein thioesterase (PubMed:9624183). Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (PubMed:9624183). Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1 (By similarity). Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes (By similarity). Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (By similarity). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (PubMed:8631810, PubMed:9644627). Has much higher thioesterase activity than lysophospholipase activity (By similarity). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.22;3.1.1.4;3.1.1.-;3.1.1.5;2.3.1.21;3.1.1.3;3.5.1.1;3.1.1.47;3.1.1.32;3.1.1.13;3.1.1.6;3.6.5.2;3.1.2.2;3.1.2.-;3.4.-.-;3.1.1.93;3.4.19.12;1.14.13.39;2.3.1.-", "go_molecular_function": "GO:0016298 lipase activity;GO:0004620 phospholipase activity;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0015908 fatty acid transport;GO:0042997 negative regulation of Golgi to plasma membrane protein transport;GO:0002084 protein depalmitoylation;GO:1905336 negative regulation of aggrephagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70470-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31053-1", "uniprot_id": "CD37_RAT", "mass": 31750.0, "length": 281, "protein_name": "Leukocyte antigen CD37", "gene_name": "Cd37", "organism": "Rat", "refseq_name": "leukocyte antigen CD37", "refseq_ac": "NP_058820", "gene_names_uniprotkb": "Cd37", "gene_names_refseq": "Cd37", "protein_names_uniprotkb": "Leukocyte antigen CD37", "protein_names_refseq": "CD37 antigen; leukocyte antigen CD37", "tax_id": 10116, "disease": "", "pathway": " (rno:29185)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2466944", "class_list": "", "function": "Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B (By similarity). Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT (By similarity). Plays also a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion (By similarity). Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling. Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001772 immunological synapse;GO:0016020 membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0042832 defense response to protozoan;GO:0050688 regulation of defense response to virus;GO:0002920 regulation of humoral immune response;GO:0002639 positive regulation of immunoglobulin production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P31053-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08874-1", "uniprot_id": "PKN2_RAT", "mass": 112069.0, "length": 985, "protein_name": "Serine/threonine-protein kinase N2", "gene_name": "Pkn2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pkn2; Pak2; Prk2; Prkcl2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase N2; 2.7.11.13; Cardiolipin-activated protein kinase Pak2; PAK-2; PKN gamma; Protease-activated kinase 2; Protein kinase C-like 2; Protein-kinase C-related kinase 2; p140 kinase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:207122); (R-RNO-5625740); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013149); (R-RNO-9856530)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "22673903;9092545;9121475", "class_list": "", "function": "PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.10.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.1;2.7.1.150;2.7.11.13;4.1.1.32;3.6.5.2;2.7.11.19;2.7.2.3;3.1.2.-;7.6.2.-;1.14.14.18;2.7.11.11;2.7.11.31;3.1.3.16;3.6.4.-;3.1.4.4;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;1.14.13.39;2.7.11.39;1.6.3.-;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042826 histone deacetylase binding;GO:0031267 small GTPase binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043297 apical junction assembly;GO:0010631 epithelial cell migration;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08874-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10687-1", "uniprot_id": "PLCB1_RAT", "mass": 138344.0, "length": 1216, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1", "gene_name": "Plcb1", "organism": "Rat", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1", "refseq_ac": "NP_001071109", "gene_names_uniprotkb": "Plcb1", "gene_names_refseq": "PLC'1; PLCbeta1; Phosphb; Plcb1; RATPHOSPHB", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 3.1.4.11; PLC-154; PLC-I; PLC-beta-1; Phosphoinositide phospholipase C-beta-1; Phospholipase C-I; Phospholipase C-beta-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; PLC-154; PLC-I; PLC-beta-1; Phospholipase C-beta1; phosphoinositide phospholipase C-beta-1; phosphoinositide phospholipase C; phospholipase C, beta 1 (phosphoinositide-specific); phospholipase C-I", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); developmental and epileptic encephalopathy 12 (Disease Ontology:DOID:0080459); amelogenesis imperfecta type 1B (Disease Ontology:DOID:0110052); amelogenesis imperfecta type 1C (Disease Ontology:DOID:0110056); Alzheimer's disease (Disease Ontology:DOID:10652); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); acute myeloid leukemia (Disease Ontology:DOID:9119); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24654); (R-RNO-112043); (R-RNO-1855204); (R-RNO-399997); (R-RNO-416476); (R-RNO-434316)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "18683930;22673903;27624933;29401590;32247043;3390863;34625112;35469845;8454637", "class_list": "", "function": "Activation of PLCbeta1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer's amyloidosis. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Elevation of phospholipase C-beta1 expression by amyloid-beta facilitates calcium overload in neuronal cells., [RefSeq, PubMed]; PLCbeta through its ability to bind TRAX plays a key role in switching PC12 cells to their differentiated state., [RefSeq, PubMed]; Results present a model in which the transient high expression of PLCbeta1 that occurs at the onset of differentiation arrests cells in the G1 phase through its association with CDK16 and allows CDK16 to transition to its postmitotic function of neurite outgrowth and trafficking of synaptic vesicles., [RefSeq, PubMed]; The Galphaq/phospholipase Cbeta signaling system represses tau aggregation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.11;3.6.5.-", "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005096 GTPase activator activity;GO:0005516 calmodulin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0070498 interleukin-1-mediated signaling pathway;GO:0060466 activation of meiosis involved in egg activation;GO:2000438 negative regulation of monocyte extravasation;GO:1903140 regulation of establishment of endothelial barrier", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P10687-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60669-1", "uniprot_id": "PKHA4_RAT", "mass": 85642.0, "length": 779, "protein_name": "Pleckstrin homology domain-containing family A member 4", "gene_name": "Plekha4", "organism": "Rat", "refseq_name": "pleckstrin homology domain-containing family A member 4", "refseq_ac": "NP_954532", "gene_names_uniprotkb": "Plekha4; Pepp1", "gene_names_refseq": "Plekha4", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 4; PEPP-1; PH domain-containing family A member 4; Phosphoinositol 3-phosphate-binding protein 1", "protein_names_refseq": "PEPP-1; PH domain-containing family A member 4; phosphoinositol 3-phosphate-binding protein 1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; pleckstrin homology domain-containing family A member 4", "tax_id": 10116, "disease": "", "pathway": " (rno:308584); (R-RNO-1660499)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P60669-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V9A7-1", "uniprot_id": "MTFR1_RAT", "mass": 36815.0, "length": 335, "protein_name": "Mitochondrial fission regulator 1", "gene_name": "Mtfr1", "organism": "Rat", "refseq_name": "mitochondrial fission regulator 1", "refseq_ac": "NP_001094447", "gene_names_uniprotkb": "Mtfr1; LOC120101654", "gene_names_refseq": "Mtfr1; RGD1304936", "protein_names_uniprotkb": "Mitochondrial fission regulator 1", "protein_names_refseq": "mitochondrial fission regulator 1", "tax_id": 10116, "disease": "", "pathway": " (rno:311403)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31622017", "class_list": "", "function": "Inhibition of the LncRNA Gpr19 attenuates ischemia-reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR-324-5p/Mtfr1 axis., [RefSeq, PubMed]; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3F823", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0000266 mitochondrial fission;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V9A7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C0R5-1", "uniprot_id": "PI3R4_RAT", "mass": 152447.0, "length": 1358, "protein_name": "Phosphoinositide 3-kinase regulatory subunit 4", "gene_name": "Pik3r4", "organism": "Rat", "refseq_name": "phosphoinositide 3-kinase regulatory subunit 4", "refseq_ac": "NP_001388143", "gene_names_uniprotkb": "Pik3r4", "gene_names_refseq": "Pik3r4", "protein_names_uniprotkb": "Phosphoinositide 3-kinase regulatory subunit 4; 2.7.11.1; PI3-kinase regulatory subunit 4", "protein_names_refseq": "PI3-kinase regulatory subunit 4; phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4, p150", "tax_id": 10116, "disease": "", "pathway": " (rno:363131); (R-RNO-109704); (R-RNO-1632852); (R-RNO-1660514); (R-RNO-1660516); (R-RNO-1660517); (R-RNO-168138); (R-RNO-5668599)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.10.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;3.1.3.48;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10;3.2.1.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0005770 late endosome;GO:0005776 autophagosome;GO:0005930 axoneme;GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0010506 regulation of autophagy;GO:0016241 regulation of macroautophagy;GO:0045022 early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C0R5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C1X9-1", "uniprot_id": "LAIR1_RAT", "mass": 29724.0, "length": 263, "protein_name": "Leukocyte-associated immunoglobulin-like receptor 1", "gene_name": "Lair1", "organism": "Rat", "refseq_name": "leukocyte-associated immunoglobulin-like receptor 1 isoform 1 precursor", "refseq_ac": "NP_001025099", "gene_names_uniprotkb": "Lair1", "gene_names_refseq": "Lair1", "protein_names_uniprotkb": "Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; rLAIR1", "protein_names_refseq": "LAIR-1; leukocyte-associated Ig-like receptor 1; leukocyte-associated immunoglobulin-like receptor 1 isoform 1 precursor; rLAIR1", "tax_id": 10116, "disease": "", "pathway": " (rno:574531); (R-RNO-198933); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15902436;32908154", "class_list": "", "function": "Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0140375 immune receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C1X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07310-1", "uniprot_id": "NRX3A_RAT", "mass": 173994.0, "length": 1578, "protein_name": "Neurexin-3", "gene_name": "Nrxn3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nrxn3", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurexin-3; Neurexin III-alpha; Neurexin-3-alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:116508); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11470830;38843836;7695896;8341647;8786425;9856994", "class_list": "", "function": "Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q07280;Q07311;Q07312;Q07313;Q07314", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0005246 calcium channel regulator activity;GO:0097109 neuroligin family protein binding;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0099054 presynapse assembly;GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q07310-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88377-1", "uniprot_id": "PI42B_RAT", "mass": 47264.0, "length": 416, "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta", "gene_name": "Pip4k2b", "organism": "Rat", "refseq_name": "phosphatidylinositol 5-phosphate 4-kinase type-2 beta", "refseq_ac": "NP_446002", "gene_names_uniprotkb": "Pip4k2b; Pip5k2b", "gene_names_refseq": "Pip4k2b; Pip5k2b", "protein_names_uniprotkb": "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; 2.7.1.149; Diphosphoinositide kinase 2-beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; PIPKIIgamma; Phosphatidylinositol 5-phosphate 4-kinase type II beta; Phosphatidylinositol-phosphate kinase IIgamma; PtdIns(5)P-4-kinase isoform 2-beta", "protein_names_refseq": "1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; 1-phosphatidylinositol-5-phosphate 4-kinase B; PI(5)P 4-kinase type II beta; PIP4KII-beta; PIPKIIgamma; diphosphoinositide kinase 2-beta; phosphatidylinositol 5-phosphate 4-kinase type II beta; phosphatidylinositol 5-phosphate 4-kinase type-2 beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; phosphatidylinositol-phosphate kinase IIgamma", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:89812); (R-RNO-1660499); (R-RNO-6811555); (R-RNO-6811558); (R-RNO-8847453)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "9685379", "class_list": "", "function": "Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:9685379). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation (By similarity). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.1.68;2.7.1.149", "go_molecular_function": "GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042803 protein homodimerization activity;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005776 autophagosome", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0010506 regulation of autophagy;GO:0046488 phosphatidylinositol metabolic process;GO:2000786 positive regulation of autophagosome assembly;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88377-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18395-1", "uniprot_id": "CSDE1_RAT", "mass": 88895.0, "length": 798, "protein_name": "Cold shock domain-containing protein E1", "gene_name": "Csde1; LOC100364335", "organism": "Rat", "refseq_name": "cold shock domain-containing protein E1 isoform 1", "refseq_ac": "NP_446458", "gene_names_uniprotkb": "Csde1; LOC100364335; Csde1; LOC100364335; Unr", "gene_names_refseq": "Csde1; Unr", "protein_names_uniprotkb": "Cold shock domain-containing protein E1; Protein UNR", "protein_names_refseq": "cold shock domain containing E1, RNA binding-like; cold shock domain-containing protein E1 isoform 1; cold shock domain-containing protein E1; upstream of NRAS", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:100364335); (rno:117180)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16469771;2204029", "class_list": "", "function": "RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Unr, together with the other proteins in the RNA binding complex, determines PTH mRNA stability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1905172 RISC complex binding;GO:0035613 RNA stem-loop binding;GO:0140517 protein-RNA adaptor activity;GO:0106222 lncRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule;GO:0070937 CRD-mediated mRNA stability complex;GO:0106002 mCRD-mediated mRNA stability complex", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:0075522 IRES-dependent viral translational initiation;GO:0045727 positive regulation of translation;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18395-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZZ80-1", "uniprot_id": "OBSL1_RAT", "mass": 197865.0, "length": 1805, "protein_name": "Obscurin-like protein 1", "gene_name": "Obsl1", "organism": "Rat", "refseq_name": "obscurin-like protein 1 isoform 2", "refseq_ac": "NP_001395974", "gene_names_uniprotkb": "Obsl1", "gene_names_refseq": "Obsl1; RGD1306073", "protein_names_uniprotkb": "Obscurin-like protein 1", "protein_names_refseq": "Obscurin-like protein 1; obscurin-like 1; obscurin-like protein 1 isoform 2", "tax_id": 10116, "disease": "3-M syndrome (Disease Ontology:DOID:0060241)", "pathway": " (rno:363259); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17289344;18477606;21572988", "class_list": "", "function": "Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (By similarity). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; OBSL1 is a critical regulator of Cul7 (cullin 7) in Golgi morphogenesis and dendrite elaboration., [RefSeq, PubMed]; OBSL1 is expressed in a broad range of tissues and localizes to the intercalated discs, to the perinuclear region, and overlying the Z lines and M bands of adult rat cardiac myocytes, [RefSeq, PubMed]; Titin mutations that have been linked to limb-girdle muscular dystrophy 2J (LGMD2J) or Salih myopathy weaken or abrogate titin-obscurin and titin-Obsl1 binding, and lead to obscurin mislocalization., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0050775 positive regulation of dendrite morphogenesis;GO:0000226 microtubule cytoskeleton organization;GO:0007088 regulation of mitotic nuclear division;GO:0007030 Golgi organization;GO:0034067 protein localization to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZZ80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35049-1", "uniprot_id": "NSMA2_RAT", "mass": 71272.0, "length": 655, "protein_name": "Sphingomyelin phosphodiesterase 3", "gene_name": "Smpd3", "organism": "Rat", "refseq_name": "sphingomyelin phosphodiesterase 3", "refseq_ac": "NP_446057", "gene_names_uniprotkb": "Smpd3; Cca1", "gene_names_refseq": "Smpd3; cca1", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase 3; 3.1.4.12; Confluent 3Y1 cell-associated protein 1; Neutral sphingomyelinase 2; Neutral sphingomyelinase II; nSMase-2; nSMase2", "protein_names_refseq": "confluent 3Y1 cell-associated 1; confluent 3Y1 cell-associated protein 1; nSMase-2; nSMase2; neutral sphingomyelin phosphodiesterase 3; neutral sphingomyelinase 2; neutral sphingomyelinase II; sphingomyelin phosphodiesterase 3, neutral membrane; sphingomyelin phosphodiesterase 3", "tax_id": 10116, "disease": "osteogenesis imperfecta type 3 (Disease Ontology:DOID:0110339); osteogenesis imperfecta type 2 (Disease Ontology:DOID:0110341); osteogenesis imperfecta (Disease Ontology:DOID:12347); transient cerebral ischemia (Disease Ontology:DOID:224); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary hypertension (Disease Ontology:DOID:6432); hypopituitarism (Disease Ontology:DOID:9406); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:94338); (R-RNO-5626978); (R-RNO-9840310)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10823942;14720208;15059969;22673903;29043558;29867196;34089907;9218439", "class_list": "", "function": "Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location (By similarity). Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions., [UniProtKB, PubMed, PubMed, UniProtKB]; Characterization of neutral sphingomyelinase activity and isoform expression in rodent skeletal muscle mitochondria., [RefSeq, PubMed]; NSMase2 is a novel regulator of autophagy and provide evidence that Golgi-localized ceramides participate in cytoprotective autophagy against starvation. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate an important function of nSMase2 in the striatum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.12;3.1.4.38;3.1.4.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0008081 phosphoric diester hydrolase activity;GO:0001786 phosphatidylserine binding;GO:0004767 sphingomyelin phosphodiesterase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0097187 dentinogenesis;GO:0071461 cellular response to redox state;GO:0085029 extracellular matrix assembly;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35049-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V7X8-1", "uniprot_id": "CP26B_RAT", "mass": 57352.0, "length": 512, "protein_name": "Cytochrome P450 26B1", "gene_name": "Cyp26b1", "organism": "Rat", "refseq_name": "cytochrome P450 26B1", "refseq_ac": "NP_851601", "gene_names_uniprotkb": "Cyp26b1", "gene_names_refseq": "Cyp26b1", "protein_names_uniprotkb": "Cytochrome P450 26B1; 1.14.13.-", "protein_names_refseq": "cytochrome P450 26B1", "tax_id": 10116, "disease": "osteochondrodysplasia (Disease Ontology:DOID:2256); craniosynostosis (Disease Ontology:DOID:2340); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:312495); (R-RNO-211916); (R-RNO-5365859)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23554885", "class_list": "", "function": "5ML induces CYP26B1-dependent angiogenesis in vitro, and arteriogenesis in vivo., [RefSeq, PubMed]; A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (By similarity). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (By similarity). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the convertion of atRA to all-trans-4-oxo-RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). Shows preference for the following substrates: atRA > 9-cis-RA > 13-cis-RA (By similarity). Plays a central role in germ cell development: acts by degrading RAs in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Essential for postnatal survival (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Also has a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YE5", "ec_number_list": "1.14.14.-;1.14.13.-", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0061436 establishment of skin barrier;GO:0071300 cellular response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V7X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27657-1", "uniprot_id": "LIPP_RAT", "mass": 51440.0, "length": 465, "protein_name": "Pancreatic triacylglycerol lipase", "gene_name": "Pnlip", "organism": "Rat", "refseq_name": "pancreatic triacylglycerol lipase precursor", "refseq_ac": "NP_037293", "gene_names_uniprotkb": "Pnlip", "gene_names_refseq": "PANLI; Pnlip", "protein_names_uniprotkb": "Pancreatic triacylglycerol lipase; 3.1.1.3; PL; Pancreatic lipase", "protein_names_refseq": "PL; pancreatic triacylglycerol lipase precursor; pancreatic triacylglycerol lipase; pancreatic triglyceride lipase", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25702); (R-RNO-192456); (R-RNO-975634)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10769148;21469501;8203536;8486693", "class_list": "", "function": "Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones., [UniProtKB, PubMed, PubMed]; Pnlip encoding pancreatic lipase is a possible candidate for intramuscular fat accumulation QTL in OLETF rat., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.3;2.3.1.51;3.1.1.4;3.1.1.23;3.1.1.79;3.1.1.6;3.1.1.88;3.1.1.-;3.1.1.5;3.1.1.28;3.1.1.32;3.1.1.13;3.1.1.116;3.1.1.1;3.1.1.67;3.1.1.26;3.1.1.34", "go_molecular_function": "GO:0016298 lipase activity;GO:0046872 metal ion binding;GO:0008970 phospholipase A1 activity;GO:0004806 triacylglycerol lipase activity;GO:0004465 lipoprotein lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006629 lipid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0030299 intestinal cholesterol absorption;GO:0033993 response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P27657-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53812-1", "uniprot_id": "PIPNB_RAT", "mass": 31450.0, "length": 271, "protein_name": "Phosphatidylinositol transfer protein beta isoform", "gene_name": "Pitpnb", "organism": "Rat", "refseq_name": "phosphatidylinositol transfer protein beta isoform", "refseq_ac": "NP_446194", "gene_names_uniprotkb": "Pitpnb", "gene_names_refseq": "Pitpnb", "protein_names_uniprotkb": "Phosphatidylinositol transfer protein beta isoform; PI-TP-beta; PtdIns transfer protein beta; PtdInsTP beta", "protein_names_refseq": "PI-TP-beta; phosphatidylinositol transfer protein beta isoform; phosphotidylinositol transfer protein, beta; ptdIns transfer protein beta; ptdInsTP beta", "tax_id": 10116, "disease": "", "pathway": " (rno:114561); (R-RNO-1483196)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16779671;16780419;18636990;7961615", "class_list": "", "function": "Catalyzes the transfer of phosphatidylinositol between membranes (PubMed:18636990). Also catalyzes the transfer of phosphatidylcholine and sphingomyelin between membranes (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; In rat liver, the single gene for PITPbeta gives rise to seven distinct protein species that can be resolved on the basis of their charge differences, [RefSeq, PubMed]; Lower protein expression of PI-TP(alpha and beta) in aged brain and in PD., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7S3", "ec_number_list": "3.1.-.-", "go_molecular_function": "GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding;GO:0008526 phosphatidylinositol transfer activity;GO:0008525 phosphatidylcholine transporter activity;GO:0120019 phosphatidylcholine transfer activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0015914 phospholipid transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P53812-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23273-1", "uniprot_id": "O1500_RAT", "mass": 35718.0, "length": 312, "protein_name": "Olfactory receptor 1500", "gene_name": "Olr1500", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Olr1500", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor 1500; Olfactory receptor-like protein I14", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:405281)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1840504", "class_list": "", "function": "Odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23273-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89040-1", "uniprot_id": "PLCB2_RAT", "mass": 134883.0, "length": 1183, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2", "gene_name": "Plcb2", "organism": "Rat", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2", "refseq_ac": "NP_445930", "gene_names_uniprotkb": "Plcb2", "gene_names_refseq": "Plcb2", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; 3.1.4.11; PLC-beta-2; Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; PKC beta II; PLC-beta-2; phosphoinositide phospholipase C-beta-2", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:85240); (R-RNO-112043); (R-RNO-1855204); (R-RNO-399997); (R-RNO-416476); (R-RNO-434316)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "18820027;20393598;36934663;8454637;9860142", "class_list": "", "function": "High glucose increases the expression of Gq/11alpha and PLC-beta proteins and associated signaling in vascular smooth muscle cells., [RefSeq, PubMed]; Levels of Galphaq, Galpha11, PLCbeta-1, and PLC-beta2 proteins, as determined by western blotting, are significantly higher in vascular smooth muscle cells exposed to high glucose than in control cells., [RefSeq, PubMed]; PKC-betaII is downregulated in the premature ovarian failure SD rat model., [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). This protein may be involved in the transduction of bitter taste stimuli (PubMed:9860142)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.11;3.6.5.-", "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005543 phospholipid binding;GO:0004629 phospholipase C activity;GO:0031683 G-protein beta/gamma-subunit complex binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0031680 G-protein beta/gamma-subunit complex;GO:0098992 neuronal dense core vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0016042 lipid catabolic process;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O89040-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16446-1", "uniprot_id": "PIPNA_RAT", "mass": 31907.0, "length": 271, "protein_name": "Phosphatidylinositol transfer protein alpha isoform", "gene_name": "Pitpna", "organism": "Rat", "refseq_name": "phosphatidylinositol transfer protein alpha isoform", "refseq_ac": "NP_058927", "gene_names_uniprotkb": "Pitpna; Pitpn", "gene_names_refseq": "Pitpna; Pitpn", "protein_names_uniprotkb": "Phosphatidylinositol transfer protein alpha isoform; PI-TP-alpha; PtdIns transfer protein alpha; PtdInsTP alpha", "protein_names_refseq": "PI-TP-alpha; phosphatidylinositol transfer protein alpha isoform; ptdIns transfer protein alpha; ptdInsTP alpha", "tax_id": 10116, "disease": "chylomicron retention disease (Disease Ontology:DOID:0060357)", "pathway": " (rno:29525)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11104777;11478882;18636990;2777797;28718450;3606604;7568025", "class_list": "", "function": "Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:18636990, PubMed:7568025). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3., [UniProtKB, UniProtKB, UniProtKB]; Cys-to-Ala mutations of PITP show that neither Cys95 nor Cys188 is essential for lipid transfer activity; however, chemical modification of Cys95 results in the loss of lipid transfer activity., [RefSeq, PubMed]; Data suggest that (1) interaction of Pitpna with membrane/lipid bilayer is spontaneous and mediated by four specific protein substructures; (2) ability of Pitpna to initiate closure around PC ligand is accompanied by loss of flexibility of two helix/loop regions, as well as of C-terminal helix; (3) energy barrier of PC/PI extraction from membrane is lowered by hydrogen bonding between lipid and Pitpna., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.-.-", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008289 lipid binding;GO:0000062 fatty-acyl-CoA binding;GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007409 axonogenesis;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P16446-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R4F8-1", "uniprot_id": "DNMBP_RAT", "mass": 176726.0, "length": 1577, "protein_name": "Dynamin-binding protein", "gene_name": "Dnmbp", "organism": "Rat", "refseq_name": "dynamin-binding protein isoform 1", "refseq_ac": "NP_001381930", "gene_names_uniprotkb": "Dnmbp; Tuba", "gene_names_refseq": "Dnmbp; Tuba", "protein_names_uniprotkb": "Dynamin-binding protein; Scaffold protein Tuba", "protein_names_refseq": "dynamin-binding protein isoform 1; scaffold protein Tuba", "tax_id": 10116, "disease": "cataract 48 (Disease Ontology:DOID:0070354)", "pathway": " (rno:309362); (R-RNO-9013148)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14506234;21232816", "class_list": "", "function": "A deficit in long term memory formation during physiological aging is associated with lower Dnmbp expression., [RefSeq, PubMed]; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (By similarity). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (PubMed:14506234)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005911 cell-cell junction", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0060271 cilium assembly;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "M0R4F8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63036-1", "uniprot_id": "DNJA1_RAT", "mass": 44868.0, "length": 397, "protein_name": "DnaJ homolog subfamily A member 1", "gene_name": "Dnaja1", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily A member 1", "refseq_ac": "NP_075223", "gene_names_uniprotkb": "Dnaja1; Hsj2; Rdj1", "gene_names_refseq": "Dnaja1; Hsj2", "protein_names_uniprotkb": "DnaJ homolog subfamily A member 1; DnaJ-like protein 1; HSJ-2; Heat shock protein J2", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily A, member 1; DnaJ-like protein 2; HSJ-2; dnaJ homolog subfamily A member 1; dnaJ-like protein 1; heat shock protein J2", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:65028); (R-RNO-3371497); (R-RNO-9841251)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10816573;22673903;26959111;38843836;9605323", "class_list": "", "function": "Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (By similarity). Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone (PubMed:10816573)., [UniProtKB, PubMed, PubMed]; The results of this study uncover a completely new role for the Hdj2 co-chaperone in tumorigenicity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P54102", "ec_number_list": "", "go_molecular_function": "GO:0055131 C3HC4-type RING finger domain binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051223 regulation of protein transport;GO:0070585 protein localization to mitochondrion;GO:1903748 negative regulation of establishment of protein localization to mitochondrion;GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P63036-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A1J4-1", "uniprot_id": "DHRS6_RAT", "mass": 26651.0, "length": 245, "protein_name": "Dehydrogenase/reductase SDR family member 6", "gene_name": "Bdh2", "organism": "Rat", "refseq_name": "dehydrogenase/reductase SDR family member 6 isoform 1", "refseq_ac": "NP_001099943", "gene_names_uniprotkb": "Bdh2; Dhrs6", "gene_names_refseq": "Bdh2; Dhrs6", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 6; (R)-beta-hydroxybutyrate dehydrogenase; 1.1.1.-; 1.1.1.104; 1.1.1.30; 3-hydroxybutyrate dehydrogenase type 2; 4-oxo-L-proline reductase; Oxidoreductase UCPA; Short chain dehydrogenase/reductase family 15C member 1", "protein_names_refseq": "(R)-beta-hydroxybutyrate dehydrogenase; 3-hydroxybutyrate dehydrogenase, type 2; 4-oxo-L-proline reductase; R-beta-hydroxybutyrate dehydrogenase; dehydrogenase/reductase (SDR family) member 6; dehydrogenase/reductase SDR family member 6 isoform 1; oxidoreductase UCPA; short chain dehydrogenase/reductase family 15C member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:295458); (R-RNO-77111)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "35150746", "class_list": "", "function": "NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (PubMed:35150746). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates. Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis. May act as a 3-hydroxybutyrate dehydrogenase., [UniProtKB, UniProtKB]; NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.300;1.1.1.184;1.1.1.122;1.6.5.10;1.1.1.30;1.1.1.104;1.1.1.-;1.1.1.21;1.1.1.372;1.1.1.54;1.1.1.189;1.1.1.197;1.1.1.196;1.1.1.71", "go_molecular_function": "GO:0051287 NAD binding;GO:0003858 3-hydroxybutyrate dehydrogenase activity;GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0016617 4-oxoproline reductase activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005777 peroxisome", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0030855 epithelial cell differentiation;GO:0019290 siderophore biosynthetic process;GO:0042168 heme metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A1J4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07151-1", "uniprot_id": "B2MG_RAT", "mass": 13720.0, "length": 119, "protein_name": "Beta-2-microglobulin", "gene_name": "B2m", "organism": "Rat", "refseq_name": "beta-2-microglobulin precursor", "refseq_ac": "NP_036644", "gene_names_uniprotkb": "B2m", "gene_names_refseq": "B2m", "protein_names_uniprotkb": "Beta-2-microglobulin", "protein_names_refseq": "beta-2-microglobulin C-terminal fragment (55 AA); beta-2-microglobulin precursor", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); peripheral artery disease (Disease Ontology:DOID:0050830); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); immunodeficiency 43 (Disease Ontology:DOID:0111981); hypertension (Disease Ontology:DOID:10763); pyelonephritis (Disease Ontology:DOID:11400); Parkinson's disease (Disease Ontology:DOID:14330); arteriosclerosis (Disease Ontology:DOID:2349); hemochromatosis (Disease Ontology:DOID:2352); acute kidney failure (Disease Ontology:DOID:3021); carotid artery disease (Disease Ontology:DOID:3407); autoimmune disease (Disease Ontology:DOID:417); ureteral obstruction (Disease Ontology:DOID:5199); proteinuria (Disease Ontology:DOID:576); encephalomyelitis (Disease Ontology:DOID:640); cataract (Disease Ontology:DOID:83); arthritis (Disease Ontology:DOID:848); measles (Disease Ontology:DOID:8622); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24223); (R-RNO-1236974); (R-RNO-1236977); (R-RNO-198933); (R-RNO-2172127); (R-RNO-2424491); (R-RNO-6798695); (R-RNO-983170)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "11163232;21454685;2689174;2911353;29393594;3309895;33472168;7969498;9493268", "class_list": "", "function": "Beta2-microglobulin as a biomarker of pulmonary fibrosis development in COPD patients., [RefSeq, PubMed]; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0023026 MHC class II protein complex binding;GO:0005198 structural molecule activity;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0032398 MHC class Ib protein complex;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0007611 learning or memory;GO:0045087 innate immune response;GO:0051289 protein homotetramerization;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:1990000 amyloid fibril formation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07151-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A693-1", "uniprot_id": "AZIN2_RAT", "mass": 49420.0, "length": 457, "protein_name": "Antizyme inhibitor 2", "gene_name": "Azin2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Azin2; Adc; Odcp", "gene_names_refseq": "", "protein_names_uniprotkb": "Antizyme inhibitor 2; AzI2; ODC-like protein; ODC-p; Ornithine decarboxylase-like protein; ornithine decarboxylase paralog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-351143)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19718454", "class_list": "", "function": "Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003824 catalytic activity;GO:0042978 ornithine decarboxylase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0006591 ornithine metabolic process;GO:0043085 positive regulation of catalytic activity;GO:0042177 negative regulation of protein catabolic process;GO:0033387 putrescine biosynthetic process from arginine, via ornithine;GO:1902269 positive regulation of polyamine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A693-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C595-1", "uniprot_id": "DUS29_RAT", "mass": 24073.0, "length": 215, "protein_name": "Dual specificity phosphatase 29", "gene_name": "Dusp29", "organism": "Rat", "refseq_name": "dual specificity phosphatase 29", "refseq_ac": "NP_001101838", "gene_names_uniprotkb": "Dusp29; Dupd1", "gene_names_refseq": "Dupd1; Dusp29", "protein_names_uniprotkb": "Dual specificity phosphatase 29; 3.1.3.16; 3.1.3.48; Dual specificity phosphatase DUPD1", "protein_names_refseq": "dual specificity phosphatase 29; dual specificity phosphatase DUPD1; dual specificity phosphatase and pro isomerase domain containing 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361003)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of intracellular signaling cascades. In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase. Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.16;2.7.10.1;3.1.3.53;3.1.3.2;3.1.3.52;3.1.3.21;3.1.3.18;3.1.3.67;3.1.3.-;3.1.3.27;3.1.3.5;2.7.11.22;3.1.3.74", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0006470 protein dephosphorylation;GO:0042692 muscle cell differentiation;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C595-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CAX5-1", "uniprot_id": "OPHN1_RAT", "mass": 91839.0, "length": 802, "protein_name": "Oligophrenin-1", "gene_name": "Ophn1", "organism": "Rat", "refseq_name": "oligophrenin-1", "refseq_ac": "NP_001101318", "gene_names_uniprotkb": "Ophn1", "gene_names_refseq": "Ophn1; Opn1", "protein_names_uniprotkb": "Oligophrenin-1", "protein_names_refseq": "oligophrenin-1", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); Billuart-type X-linked syndromic intellectual developmental disorder (Disease Ontology:DOID:0080311)", "pathway": " (rno:312108); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013408); (R-RNO-9013409); (R-RNO-9013423)", "pathway_count": 11, "publication_count": 7, "publication_id_list": "15026118;15034583;19481455;19487570;21874017;24966368;35871097", "class_list": "", "function": "Oligophrenin 1 is found in glial cells forming myelin sheaths in the vagus nerve, sciatic nerve and dorsal roots of guinea-pig, rat and human, in chromaffin cells of the adrenal medulla, and in chromaffin cells associated with sympathetic ganglia., [RefSeq, PubMed]; Our findings unveil a novel role for OPHN1 as an interaction partner of Homer1b/c in spine endocytic zone positioning, and provide new mechanistic insight into how genetic deficits in OPHN1 can lead to impaired synapse maturation and plasticity., [RefSeq, PubMed]; Positive Allosteric Modulation of mGlu1 Reverses Cocaine-Induced Behavioral and Synaptic Plasticity Through the Integrated Stress Response and Oligophrenin-1., [RefSeq, PubMed]; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function, in hippocampal neurons. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0030425 dendrite;GO:0043195 terminal bouton", "go_biological_process": "GO:0007165 signal transduction;GO:0030100 regulation of endocytosis;GO:0031175 neuron projection development;GO:0034329 cell junction assembly;GO:0045198 establishment of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P0CAX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14841-1", "uniprot_id": "CYTC_RAT", "mass": 15437.0, "length": 140, "protein_name": "Cystatin-C", "gene_name": "Cst3", "organism": "Rat", "refseq_name": "cystatin-C precursor", "refseq_ac": "NP_036969", "gene_names_uniprotkb": "Cst3", "gene_names_refseq": "CYSC; Cst3", "protein_names_uniprotkb": "Cystatin-C; Cystatin-3", "protein_names_refseq": "Cystatin C (cysteine proteinase inhibitor); cystatin-3; cystatin-C precursor", "tax_id": 10116, "disease": "left ventricular failure (Disease Ontology:DOID:0051064); CST3-related cerebral amyloid angiopathy (Disease Ontology:DOID:0070027); lupus nephritis (Disease Ontology:DOID:0080162); COVID-19 (Disease Ontology:DOID:0080600); age related macular degeneration 11 (Disease Ontology:DOID:0110023); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); intracranial aneurysm (Disease Ontology:DOID:10941); iron deficiency anemia (Disease Ontology:DOID:11758); Guillain-Barre syndrome (Disease Ontology:DOID:12842); osteopetrosis (Disease Ontology:DOID:13533); polyneuropathy (Disease Ontology:DOID:1389); interstitial cystitis (Disease Ontology:DOID:13949); breast cancer (Disease Ontology:DOID:1612); atherosclerosis (Disease Ontology:DOID:1936); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); endometriosis (Disease Ontology:DOID:289); glomerulonephritis (Disease Ontology:DOID:2921); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); peripheral vascular disease (Disease Ontology:DOID:341); systemic scleroderma (Disease Ontology:DOID:418); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); kidney disease (Disease Ontology:DOID:557); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); amyloidosis (Disease Ontology:DOID:9120); type 2 diabetes mellitus (Disease Ontology:DOID:9352); vesicoureteral reflux (Disease Ontology:DOID:9620); pulmonary emphysema (Disease Ontology:DOID:9675); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25307); (R-RNO-381426); (R-RNO-6798695); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "1563513;2400577;24090084;2689174;3044831;31801142;33030263;36899554;38676809", "class_list": "", "function": "As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L., [UniProtKB]; Cystatin C Attenuates Perihematomal Secondary Brain Injury by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage., [RefSeq, PubMed]; Cystatin C in Evaluating Renal Function in Ureteral Calculi Hydronephrosis in Adults., [RefSeq, PubMed]; Cystatin C regulates the cytotoxicity of infection-induced endothelial-derived beta-amyloid., [RefSeq, PubMed]; Expression and role of cystatin C in hyperthermia-induced brain injury in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 98, "biomarker_type": "", "glycan_count": 5, "disease_count": 33, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5M968", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0030414 peptidase inhibitor activity;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006952 defense response;GO:0008284 positive regulation of cell population proliferation;GO:0001666 response to hypoxia;GO:0031667 response to nutrient levels;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P14841-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02683-1", "uniprot_id": "NSG1_RAT", "mass": 20943.0, "length": 185, "protein_name": "Neuronal vesicle trafficking-associated protein 1", "gene_name": "Nsg1", "organism": "Rat", "refseq_name": "neuronal vesicle trafficking-associated protein 1", "refseq_ac": "NP_077042", "gene_names_uniprotkb": "Nsg1; Bsmrb", "gene_names_refseq": "Bsmrb; Neep21; Nsg1; PEP1", "protein_names_uniprotkb": "Neuronal vesicle trafficking-associated protein 1; Brain neuron cytoplasmic protein 1/2; Neuron-enriched endosomal protein of 21 kDa; Neuron-specific protein family member 1", "protein_names_refseq": "brain neuron cytoplasmic protein 1/2; brain specific mRNA b; neuron specific gene family member 1; neuron-enriched endosomal protein of 21 kDa; neuron-specific protein family member 1; neuronal vesicle trafficking-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:25247)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12070131;15187090;15911354;16037816;18299352;19063943;28874679;6347394;9013775;9461575", "class_list": "", "function": "NEEP21 is a neuronal protein that is localized to the early endosomal pathway and is necessary for correct receptor recycling in neurons., [RefSeq, PubMed]; Our findings are consistent with a role for NEEP21 in facilitating vesicular transport of GluR2 between intracellular compartments and the postsynaptic plasma membrane., [RefSeq, PubMed]; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway (PubMed:15911354, PubMed:18299352). Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (PubMed:15911354). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (PubMed:18299352). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The essential role of NEEP21 in the recycling mechanism; this protein acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway, [RefSeq, PubMed]; Together, we conclude that NEEP21 contributes to the regulation of synaptic transmission and plasticity in slice cultures by affecting the recycling and targeting of AMPA receptors to the synapse., [RefSeq, PubMed]; We identify the neuronal-specific endosomal protein NEEP21 (neuron-enriched endosomal protein of 21 kD) as a regulator of L1/NgCAM sorting in somatodendritic endosomes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02684;Q6P9Y0", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0032051 clathrin light chain binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0099627 neurotransmitter receptor cycle;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0006915 apoptotic process;GO:0042982 amyloid precursor protein metabolic process;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P02683-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55091-1", "uniprot_id": "CTRC_RAT", "mass": 29374.0, "length": 268, "protein_name": "Chymotrypsin-C", "gene_name": "Ctrc", "organism": "Rat", "refseq_name": "chymotrypsin-C precursor", "refseq_ac": "NP_001071117", "gene_names_uniprotkb": "Ctrc", "gene_names_refseq": "Ctrc", "protein_names_uniprotkb": "Chymotrypsin-C; 3.4.21.2; Caldecrin; Serum calcium-decreasing factor", "protein_names_refseq": "caldecrin; chymotrypsin-C precursor; preprocaldecrin; serum calcium-decreasing factor", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065)", "pathway": " (rno:362653)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1537555;21828354;8530454;9538241", "class_list": "", "function": "Possibly involved in enamel development, [RefSeq, PubMed]; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors (By similarity). Has chymotrypsin-type protease activity and hypocalcemic activity (By similarity). Cleaves TRY4 and TRY5 and thereby inhibits their autoactivation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63188", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55091-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38444-1", "uniprot_id": "AVR2A_RAT", "mass": 57893.0, "length": 513, "protein_name": "Activin receptor type-2A", "gene_name": "Acvr2a", "organism": "Rat", "refseq_name": "activin receptor type-2A precursor", "refseq_ac": "NP_113759", "gene_names_uniprotkb": "Acvr2a; Actrii; Acvr2; ENSRNOG00000065897", "gene_names_refseq": "Acvr2a; Acvr2; rActR-II", "protein_names_uniprotkb": "Activin receptor type-2A; 2.7.11.30; ACTR-IIA; Activin receptor type IIA", "protein_names_refseq": "ACTR-IIA; activin A receptor, type IIA; activin receptor IIA; activin receptor type IIA; activin receptor type-2A precursor; activin receptor type-2A; type II activin receptor", "tax_id": 10116, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); Marfan syndrome (Disease Ontology:DOID:14323); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); Lynch syndrome (Disease Ontology:DOID:3883); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:29263); (R-RNO-1502540); (R-RNO-201451); (R-RNO-9839406)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "1385212;7916681", "class_list": "", "function": "On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.7.11.30", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0015026 coreceptor activity;GO:0019838 growth factor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0048179 activin receptor complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P38444-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70513-1", "uniprot_id": "LG3BP_RAT", "mass": 63742.0, "length": 574, "protein_name": "Galectin-3-binding protein", "gene_name": "Lgals3bp", "organism": "Rat", "refseq_name": "galectin-3-binding protein precursor", "refseq_ac": "NP_620796", "gene_names_uniprotkb": "Lgals3bp", "gene_names_refseq": "CyCAP; Lgals3bp; MAC2BP; Ppicap; mama", "protein_names_uniprotkb": "Galectin-3-binding protein; CyCAP; Cyp-C-associated protein; Lectin galactoside-binding soluble 3-binding protein; MAC2BP; Mac-2 BP; Mac-2-binding protein; Protein 90K", "protein_names_refseq": "90K protein; cyp-C-associated protein; galectin-3-binding protein precursor; lectin galactoside-binding soluble 3-binding protein; mac-2 BP; mac-2-binding protein; peptidylprolyl isomerase C-associated protein; protein 90K", "tax_id": 10116, "disease": "", "pathway": " (rno:245955); (R-RNO-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12650929;15231701", "class_list": "", "function": "Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q66HR4;Q6Q8R9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70513-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09018-1", "uniprot_id": "COT2_RAT", "mass": 45601.0, "length": 414, "protein_name": "COUP transcription factor 2", "gene_name": "Nr2f1; Nr2f2", "organism": "Rat", "refseq_name": "COUP transcription factor 2", "refseq_ac": "NP_542956", "gene_names_uniprotkb": "Nr2f1; Nr2f2; Arp1; Nr2f1; Tfcoup2", "gene_names_refseq": "Nr2f2; Tfcoup2", "protein_names_uniprotkb": "COUP transcription factor 2; ARP-1; Apolipoprotein A-I regulatory protein 1; COUP transcription factor II; COUP-TF II; COUP-TF2; COUPb; Nuclear receptor subfamily 2 group F member 2; Ovalbumin upstream promoter beta nuclear receptor", "protein_names_refseq": "ARP-1; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2; COUPb; apolipoprotein A-I regulatory protein 1; apolipoprotein AI regulatory protein 1; ovalbumin upstream promoter beta nuclear receptor", "tax_id": 10116, "disease": "46,XX sex reversal 5 (Disease Ontology:DOID:0080943); Bosch-Boonstra-Schaaf optic atrophy syndrome (Disease Ontology:DOID:0112226); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:113984); (rno:81808); (R-RNO-383280); (R-RNO-9940951)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "12777384;24234421;25372459;25687237;36648143;8910285", "class_list": "", "function": "ARP-1/COUP-TFII acts as both a transcriptional repressor of microsomal triglyceride transfer protein and as a transcription activator of CYP7A1., [RefSeq, PubMed]; Apoc3 expression is regulated by HNF4a and COUP-TFII but not by retinoic acid in rat hepatocytes., [RefSeq, PubMed]; COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by up-regulating Krox20., [RefSeq, PubMed]; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development., [UniProtKB, UniProtKB]; Nr2f2 mutation in the hinge region attenuates salt-sensitive hypertension Publication Status: Online-Only, [RefSeq, PubMed]; These data demonstrate that Nr2f2 is a direct target of POU4F3 in vitro and that this regulatory relationship may be relevant to hair cell development and survival. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060838 lymphatic endothelial cell fate commitment;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O09018-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0V8T5-1", "uniprot_id": "CTP5B_RAT", "mass": 144159.0, "length": 1292, "protein_name": "Contactin-associated protein like 5-2", "gene_name": "Cntnap5a; Cntnap5bl1; Cntnap5b; Cntnap5c", "organism": "Rat", "refseq_name": "similar to contactin associated protein-like 5 isoform 1 precursor", "refseq_ac": "NP_001316828", "gene_names_uniprotkb": "Cntnap5a; Cntnap5bl1; Cntnap5b; Cntnap5c; Caspr5-2; Cntnap5a; Cntnap5bl1; Cntnap5c; LOC304725", "gene_names_refseq": "Caspr5-2; Cntnap5bl1", "protein_names_uniprotkb": "Contactin-associated protein like 5-2; Cell recognition molecule Caspr5-2; Cell recognition molecule Caspr5b; Contactin-associated protein-like 5b", "protein_names_refseq": "contactin associated protein-like 5-2; similar to contactin associated protein-like 5 isoform 1 precursor", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308)", "pathway": " (rno:304725)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16845472;29393594", "class_list": "", "function": "May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0001650 fibrillar center;GO:0005604 basement membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0001895 retina homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0V8T5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70552-1", "uniprot_id": "GFRP_RAT", "mass": 9672.0, "length": 84, "protein_name": "GTP cyclohydrolase 1 feedback regulatory protein", "gene_name": "Gchfr", "organism": "Rat", "refseq_name": "GTP cyclohydrolase 1 feedback regulatory protein", "refseq_ac": "NP_598279", "gene_names_uniprotkb": "Gchfr; Gfrp", "gene_names_refseq": "Gchfr", "protein_names_uniprotkb": "GTP cyclohydrolase 1 feedback regulatory protein; GFRP; GTP cyclohydrolase I feedback regulatory protein; p35", "protein_names_refseq": "GFRP; GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulatory protein; p35", "tax_id": 10116, "disease": "", "pathway": " (rno:171128); (R-RNO-1474151)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11580249;11818540;15292175;15448133;15649650;21163945;8702680;9092499", "class_list": "", "function": "Allosteric regulation of GTPCH-I activity in the cardiovascular system maybe an important mechanism regulating BH4 levels through GTPCH-I feedback regulatory protein signaling, [RefSeq, PubMed]; Conformational analysis of GTP cyclohydrolase I binding GFRP, its feedback regulatory protein, [RefSeq, PubMed]; GTPCH feedback regulatory protein has a role in GTCPCH inhibition by DAHP (2,4-diamino-6-hydroxypyrimidine), [RefSeq, PubMed]; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine., [UniProtKB, UniProtKB, UniProtKB]; The N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0044877 protein-containing complex binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0009890 negative regulation of biosynthetic process;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P70552-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89042-1", "uniprot_id": "DPOLA_RAT", "mass": 165306.0, "length": 1451, "protein_name": "DNA polymerase alpha catalytic subunit", "gene_name": "Pola1", "organism": "Rat", "refseq_name": "DNA polymerase alpha catalytic subunit", "refseq_ac": "NP_445931", "gene_names_uniprotkb": "Pola1; Pola", "gene_names_refseq": "Pola1", "protein_names_uniprotkb": "DNA polymerase alpha catalytic subunit; 2.7.7.7; DNA polymerase alpha catalytic subunit p180", "protein_names_refseq": "DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha catalytic subunit; DNA polymerase alpha subunit I; polymerase (DNA directed), alpha 1, catalytic subunit; polymerase (DNA) alpha 1, catalytic subunit", "tax_id": 10116, "disease": "X-linked reticulate pigmentary disorder (Disease Ontology:DOID:0111834); Van Esch-O'Driscoll syndrome (Disease Ontology:DOID:0111840)", "pathway": " (rno:85241); (R-RNO-113501); (R-RNO-174411); (R-RNO-174430); (R-RNO-68952); (R-RNO-68962); (R-RNO-69091); (R-RNO-69166); (R-RNO-69183)", "pathway_count": 9, "publication_count": 2, "publication_id_list": "10541966;15615704", "class_list": "", "function": "Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:10541966). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (By similarity) (PubMed:10541966)., [UniProtKB, PubMed, UniProtKB]; YB-1 mediates DNA polymerase alpha gene expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.7;2.7.7.102;3.6.4.12;5.6.2.4;2.7.7.49;2.7.11.1;2.7.7.31;2.7.7.-;3.1.11.-;4.2.99.18;4.2.99.-;3.1.-.-;2.7.11.22", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003887 DNA-directed DNA polymerase activity;GO:0019103 pyrimidine nucleotide binding;GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006272 leading strand elongation;GO:0006273 lagging strand elongation;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O89042-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88407-1", "uniprot_id": "LFG2_RAT", "mass": 35036.0, "length": 316, "protein_name": "Protein lifeguard 2", "gene_name": "Faim2", "organism": "Rat", "refseq_name": "protein lifeguard 2", "refseq_ac": "NP_653357", "gene_names_uniprotkb": "Faim2; LOC102551901; Lfg2; Lfg; Nmp35", "gene_names_refseq": "Faim2; Lfg; NMP35", "protein_names_uniprotkb": "Protein lifeguard 2; Fas apoptotic inhibitory molecule 2; Neural membrane protein 35", "protein_names_refseq": "lifeguard; neural membrane protein 35; protein lifeguard 2-like; protein lifeguard 2", "tax_id": 10116, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (rno:246274)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12414123;16033886;22627920;23097042;9698393", "class_list": "", "function": "Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity)., [UniProtKB]; Data show that NMP35 supports axonal growth, and overexpression of an axonally targeted NMP35 mRNA is sufficient to increase axonal outgrowth., [RefSeq, PubMed]; Expression of Etv5, Faim2, Fto, Negr1 but not Sh2b1 is affected by nutritional state in these two areas, and the relationship between nutritional state and expression levels of obesity-associated genes in two brain areas relevant to feeding., [RefSeq, PubMed]; LFG mediated the FasL resistance of cerebellar granular cells to apoptosis, [RefSeq, PubMed]; NMP35 protein occurs throughout the brain and spinal cord, especially in dendrites of several neuronal cell types and in the surrounding neuropil. NMP35 co-localizes with the glutamate receptor GluR2 and the presynaptic vesicle protein synaptophysin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0021681 cerebellar granular layer development;GO:0002931 response to ischemia;GO:0006915 apoptotic process;GO:0043524 negative regulation of neuron apoptotic process;GO:0021680 cerebellar Purkinje cell layer development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88407-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35400-1", "uniprot_id": "GRM7_RAT", "mass": 102232.0, "length": 915, "protein_name": "Metabotropic glutamate receptor 7", "gene_name": "Grm7", "organism": "Rat", "refseq_name": "metabotropic glutamate receptor 7 precursor", "refseq_ac": "NP_112302", "gene_names_uniprotkb": "Grm7; Gprc1g; Mglur7", "gene_names_refseq": "Grm7", "protein_names_uniprotkb": "Metabotropic glutamate receptor 7; mGluR7", "protein_names_refseq": "glutamate receptor, metabotropic 7; mGluR7; metabotropic glutamate receptor 7 precursor; metabotropic glutamate receptor 7; metabotropic glutamate receptor mGluR7; metabotropic glutamate receptor subtype 7b", "tax_id": 10116, "disease": "", "pathway": " (rno:81672); (R-RNO-418594); (R-RNO-420499)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11122333;17360426;27488423;29505788;31627896;33500274;38843836;8145723;8288585", "class_list": "", "function": "Analyses of NMR data suggested that the binding between Ca(2+)-saturated calmodulin (Ca(2+)/CaM) and mGluR7 occurs in some conformational equilibrium manner. The unique CaM-binding properties caused by Met872 may be related to mGluR7's function., [RefSeq, PubMed]; Findings demonstrated that the glutamic acid and mGluR7 in hippocampal CA3 region are involved in the modulation of nociceptive information transmission by regulating pain-evoked electric activities of pain-excited neurons and pain-inhibited neurons., [RefSeq, PubMed]; G protein-coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; In control rats, mGluR7 stimulation facilitated pain responses and consistently modulated the rostral ventromedial medulla and dorsal reticular nucleus neuron activity. In neuropathic rats, AMN082 inhibited pain and consistently changed the rostral ventromedial medulla and dorsal reticular nucleus neural activity., [RefSeq, PubMed]; Pathogenic GRM7 Mutations Associated with Neurodevelopmental Disorders Impair Axon Outgrowth and Presynaptic Terminal Development., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007611 learning or memory;GO:0007613 memory;GO:0008306 associative learning;GO:0030534 adult behavior", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P35400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07522-1", "uniprot_id": "EGF_RAT", "mass": 124126.0, "length": 1133, "protein_name": "Pro-epidermal growth factor", "gene_name": "Egf", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Egf; LOC100910178", "gene_names_refseq": "", "protein_names_uniprotkb": "Pro-epidermal growth factor; EGF", "protein_names_refseq": "", "tax_id": 10116, "disease": "Zollinger-Ellison syndrome (Disease Ontology:DOID:0050782); inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); primary hypomagnesemia (Disease Ontology:DOID:0060879); renal hypomagnesemia 4 (Disease Ontology:DOID:0060882); lupus nephritis (Disease Ontology:DOID:0080162); Alzheimer's disease (Disease Ontology:DOID:10652); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); acute kidney failure (Disease Ontology:DOID:3021); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); gallbladder cancer (Disease Ontology:DOID:3121); oligodendroglioma (Disease Ontology:DOID:3181); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatitis (Disease Ontology:DOID:4989); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (rno:25313); (R-RNO-114608); (R-RNO-1227986); (R-RNO-1236394); (R-RNO-1250196); (R-RNO-1257604); (R-RNO-177929); (R-RNO-179812); (R-RNO-180292); (R-RNO-180336); (R-RNO-182971); (R-RNO-1963642); (R-RNO-212718); (R-RNO-5673001); (R-RNO-6785631); (R-RNO-6811558); (R-RNO-8847993); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8863795); (R-RNO-9009391); (R-RNO-9013507)", "pathway_count": 22, "publication_count": 3, "publication_id_list": "1524680;3000782;3262867", "class_list": "", "function": "EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q63183", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0016020 membrane", "go_biological_process": "GO:0090279 regulation of calcium ion import;GO:1902966 positive regulation of protein localization to early endosome;GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0051223 regulation of protein transport;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P07522-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80430-1", "uniprot_id": "CX6B1_RAT", "mass": 1040.0, "length": 8, "protein_name": "Cytochrome c oxidase subunit 6B1", "gene_name": "Cox6b1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cox6b1; Cox6b", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6B1; COX VIb-1; Cytochrome c oxidase subunit VIb isoform 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "mitochondrial complex IV deficiency nuclear type 7 (Disease Ontology:DOID:0070494); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "27213235;7601105", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P80430-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63219-1", "uniprot_id": "GBG5_RAT", "mass": 7318.0, "length": 68, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "gene_name": "Gng5", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "refseq_ac": "NP_077353", "gene_names_uniprotkb": "Gng5; Gng5-ps4; Gngt5", "gene_names_refseq": "Gng5", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "protein_names_refseq": "G protein gamma-5 subunit; guanine nucleotide binding protein (G protein), gamma 5 subunit; guanine nucleotide binding protein gamma 5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:79218); (R-RNO-1296041); (R-RNO-202040); (R-RNO-381676); (R-RNO-392170); (R-RNO-392451); (R-RNO-400042); (R-RNO-4086398); (R-RNO-416476); (R-RNO-418594); (R-RNO-418597); (R-RNO-420092); (R-RNO-428930); (R-RNO-432040); (R-RNO-456926); (R-RNO-8964616); (R-RNO-9856530); (R-RNO-997272)", "pathway_count": 18, "publication_count": 1, "publication_id_list": "1549114", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P30670;Q61015", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0031680 G-protein beta/gamma-subunit complex;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:2000179 positive regulation of neural precursor cell proliferation;GO:0072513 positive regulation of secondary heart field cardioblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63219-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88182-1", "uniprot_id": "FGF18_RAT", "mass": 23951.0, "length": 207, "protein_name": "Fibroblast growth factor 18", "gene_name": "Fgf18", "organism": "Rat", "refseq_name": "fibroblast growth factor 18 precursor", "refseq_ac": "NP_062072", "gene_names_uniprotkb": "Fgf18", "gene_names_refseq": "Fgf18", "protein_names_uniprotkb": "Fibroblast growth factor 18; FGF-18", "protein_names_refseq": "FGF-18; fibroblast growth factor 18 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:29369); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190322); (R-RNO-190371); (R-RNO-190372); (R-RNO-190375); (R-RNO-5654221); (R-RNO-5654227); (R-RNO-5654228); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5654720); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5658623); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 25, "publication_count": 4, "publication_id_list": "12738892;21454685;23979401;9660775", "class_list": "", "function": "Downregulation of FGF-18 gene expression in nitrofen-induced hypoplastic lungs suggests that decreased FGF-18 expression during the canalicular-saccular stages, [RefSeq, PubMed]; FGF18 is an effective neuroprotective agent in a rat model of transient middle cerebral artery occlusion, [RefSeq, PubMed]; Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0001525 angiogenesis;GO:0007399 nervous system development;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10817-1", "uniprot_id": "CX6A2_RAT", "mass": 10487.0, "length": 94, "protein_name": "Cytochrome c oxidase subunit 6A2, mitochondrial", "gene_name": "Cox6a2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cox6a2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6A2, mitochondrial; COXVIAH; Cytochrome c oxidase polypeptide VIa-heart", "protein_names_refseq": "", "tax_id": 10116, "disease": "mitochondrial complex IV deficiency nuclear type 18 (Disease Ontology:DOID:0070503); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (rno:25278); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "2153407;2461293", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0030234 enzyme regulator activity;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P10817-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70173-1", "uniprot_id": "P3C2G_RAT", "mass": 170975.0, "length": 1505, "protein_name": "Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma", "gene_name": "Pik3c2g", "organism": "Rat", "refseq_name": "phosphatidylinositol 3-kinase C2 domain-containing subunit gamma", "refseq_ac": "NP_446375", "gene_names_uniprotkb": "Pik3c2g", "gene_names_refseq": "LRRG00132; Pik3c2g", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma; 2.7.1.137; 2.7.1.154; PI3K-C2-gamma; Phosphoinositide 3-kinase-C2-gamma; PtdIns-3-kinase C2 subunit gamma", "protein_names_refseq": "PI3K-C2-gamma; PI3K-C2gamma; phosphatidylinositol 3-kinase C2 domain-containing subunit gamma; phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide; phosphoinositide 3-Kinase-C2-gamma; phosphoinositide-3-kinase, class 2, gamma polypeptide; ptdIns-3-kinase C2 gamma; ptdIns-3-kinase C2 subunit gamma", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:116720); (R-RNO-1660499); (R-RNO-1660514)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12464394;12482897;15362046;9516481", "class_list": "", "function": "By regulating PKC-/delta-dependent signals, PI3K can play a key role in the development of hepatic tolerance to hypoxia/reperfusion., [RefSeq, PubMed]; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (PubMed:9516481). May play a role in SDF1A-stimulated chemotaxis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Leptin, via PI 3-kinase-driven activation of BK channels, elicits novel mechanism for controlling neuronal excitability. Novel action of leptin could provide an alternative therapeutic target in the management of epilepsy., [RefSeq, PubMed]; PI3-Kgamma directly participates in multiple in vivo pathways involved in regulating neutrophil apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.1.153;2.7.1.137;2.7.1.154;2.7.7.49", "go_molecular_function": "GO:0005524 ATP binding;GO:0035091 phosphatidylinositol binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity;GO:0003964 RNA-directed DNA polymerase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0006935 chemotaxis;GO:0016477 cell migration;GO:0048015 phosphatidylinositol-mediated signaling;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70173-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZEF4-1", "uniprot_id": "CUL7_RAT", "mass": 192660.0, "length": 1692, "protein_name": "Cullin-7", "gene_name": "Cul7", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cul7", "gene_names_refseq": "", "protein_names_uniprotkb": "Cullin-7; CUL-7", "protein_names_refseq": "", "tax_id": 10116, "disease": "3-M syndrome (Disease Ontology:DOID:0060241)", "pathway": " (rno:680835); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21572988;22673903", "class_list": "", "function": "Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity (By similarity). It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (By similarity). The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53 (By similarity). However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1 (By similarity). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (By similarity). The Cul7-RING(FBXW8) complex also mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (By similarity). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (By similarity). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (By similarity). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (By similarity). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may have additional functions (By similarity). Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0031467 Cul7-RING ubiquitin ligase complex;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0001570 vasculogenesis;GO:0001890 placenta development;GO:0016567 protein ubiquitination;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZEF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51590-1", "uniprot_id": "CP2J3_RAT", "mass": 57969.0, "length": 502, "protein_name": "Cytochrome P450 2J3", "gene_name": "Cyp2j10; Cyp2j3; Cyp2j4", "organism": "Rat", "refseq_name": "cytochrome P450 2J3", "refseq_ac": "NP_786942", "gene_names_uniprotkb": "Cyp2j10; Cyp2j3; Cyp2j4; Cyp2j10; Cyp2j3; Cyp2j9; LOC100912642", "gene_names_refseq": "Cyp2j3; Cyp2j9", "protein_names_uniprotkb": "Cytochrome P450 2J3; 1.14.14.1; CYPIIJ3", "protein_names_refseq": "CYPIIJ3; cytochrome P450 2J3; cytochrome P450 monooxygenase; cytochrome P450, 2j9; cytochrome P450, family 2, subfamily j, polypeptide 9", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); pre-eclampsia (Disease Ontology:DOID:10591); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (rno:313373); (rno:313375); (rno:65210); (R-RNO-211935); (R-RNO-211981); (R-RNO-2142670)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "15026419;20068141;21105892;22189162;22885143;23515292;28237619;31271766;32707261;9139707", "class_list": "", "function": "Beneficial roles of the CYP epoxygenase 2J3 and its metabolites epoxyeicosatrienoic acids on adiponectin expression and secretion., [RefSeq, PubMed]; CYP2J3 is the principal P450 responsible for vitamin D3 25-hydroxylation in rat liver, [RefSeq, PubMed]; CYP2J3-derived epoxyeicosatrienoic acids may alleviate insulin resistance at least in part through upregulated eNOS expression. Erratum:[Cardiovasc Diabetol. 2014;13:17] Publication Status: Online-Only, [RefSeq, PubMed]; Endogenous activation of CYP2J3/EET may be an essential trigger leading to the protective effects of ischemic Post-conditioning, but not ischemic preconditioning, in the rat heart., [RefSeq, PubMed]; Increases in CYP2J3 mRNA levels were observed in the frontal cortex, hippocampus, cerebellum, and brain stem from rats that received the subcutaneous injection with a subneurotoxic dose of monosodium l-glutamate., [RefSeq, PubMed]; Inflammation in astrocytes could down-regulate CYP2J3 mRNA, protein and activity. Inhibition of NF-kappaB prevented the down-regulation of CYP2J3 mRNA and protein .NF-kappaB is able to bind to at least two response elements in the promoter of Cyp2j3., [RefSeq, PubMed]; Neuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain., [RefSeq, PubMed]; Overexpression of CYP2J3 protects against diabetes and insulin resistance in peripheral tissues through activation of insulin receptor and AMP kinase pathways, [RefSeq, PubMed]; The protein levels of CYP 2c6, 2e1 and 2j3 increased in the ischemic region of the rat hearts, while the mRNA levels of CYPs were unchanged., [RefSeq, PubMed]; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation mainly to 14,15-, 11,12-, and 8,9-epoxyeicosatrienoic acids (EET). It also acts as an omega-1-hydroxylase by metabolizing arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-OH-AA)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBD7", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0008404 arachidonate 14,15-epoxygenase activity;GO:0008405 arachidonate 11,12-epoxygenase activity;GO:0071614 linoleic acid epoxygenase activity;GO:0005506 iron ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043651 linoleic acid metabolic process;GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway;GO:0006082 organic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P51590-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53563-1", "uniprot_id": "B2CL1_RAT", "mass": 26158.0, "length": 233, "protein_name": "Bcl-2-like protein 1", "gene_name": "Bcl2l1", "organism": "Rat", "refseq_name": "bcl-2-like protein 1 isoform 2", "refseq_ac": "NP_001028842", "gene_names_uniprotkb": "Bcl2l1; AC098008.1; Bclx; Blc2l", "gene_names_refseq": "Bcl-xl; Bcl2l1; Bcl2l; Bclx; bcl-X", "protein_names_uniprotkb": "Bcl-2-like protein 1; Apoptosis regulator Bcl-X; Bcl2-L-1", "protein_names_refseq": "B cell lymphoma 2 like; B cell lymphoma like X; apoptosis regulator Bcl-X; bcl-2-like protein 1 isoform 2; bcl-2-like protein 1; bcl2-L-1", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); spondyloepimetaphyseal dysplasia (Disease Ontology:DOID:0080027); spondyloepimetaphyseal dysplasia, Strudwick type (Disease Ontology:DOID:0080028); hypochondrogenesis (Disease Ontology:DOID:0080044); Kniest dysplasia (Disease Ontology:DOID:0080045); Stickler syndrome (Disease Ontology:DOID:0080046); achondrogenesis type II (Disease Ontology:DOID:0080056); Stickler syndrome 1 (Disease Ontology:DOID:0080676); multiple epiphyseal dysplasia with myopia and deafness (Disease Ontology:DOID:0111348); Torrance type platyspondylic dysplasia (Disease Ontology:DOID:0111508); spondyloperipheral dysplasia (Disease Ontology:DOID:0112195); spondyloepiphyseal dysplasia Stanescu type (Disease Ontology:DOID:0112281); spondylometaphyseal dysplasia Algerian type (Disease Ontology:DOID:0112296); osteonecrosis (Disease Ontology:DOID:10159); prostate carcinoma (Disease Ontology:DOID:10286); lymphoid leukemia (Disease Ontology:DOID:1037); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); spondyloarthropathy (Disease Ontology:DOID:1123); myopia (Disease Ontology:DOID:11830); leiomyoma (Disease Ontology:DOID:127); dilated cardiomyopathy (Disease Ontology:DOID:12930); endometrial cancer (Disease Ontology:DOID:1380); uterus interstitial leiomyoma (Disease Ontology:DOID:13955); Legg-Calve-Perthes disease (Disease Ontology:DOID:14415); hypothyroidism (Disease Ontology:DOID:1459); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); melanoma (Disease Ontology:DOID:1909); nephroblastoma (Disease Ontology:DOID:2154); osteochondrodysplasia (Disease Ontology:DOID:2256); brain ischemia (Disease Ontology:DOID:2316); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); chondrosarcoma (Disease Ontology:DOID:3371); breast carcinoma (Disease Ontology:DOID:3459); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); retinal detachment (Disease Ontology:DOID:5327); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); cleft palate (Disease Ontology:DOID:674); hepatocellular carcinoma (Disease Ontology:DOID:684); hematopoietic system disease (Disease Ontology:DOID:74); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); chorioretinitis (Disease Ontology:DOID:8886); polycythemia vera (Disease Ontology:DOID:8997); degenerative disc disease (Disease Ontology:DOID:90); acute myeloid leukemia (Disease Ontology:DOID:9119); ocular hypertension (Disease Ontology:DOID:9282); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:24888); (R-RNO-111453); (R-RNO-844455); (R-RNO-9648002)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "18250306;21926988;23792689;33340237;36982731;7828536;8662675;9346936", "class_list": "", "function": "BCL-XL Overexpression Protects Pancreatic beta-Cells against Cytokine- and Palmitate-Induced Apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Isoform Bcl-X(S) promotes apoptosis., [UniProtKB]; Pharmacological preconditioning protects from ischemia/reperfusion-induced apoptosis by modulating Bcl-xL expression through a ROS-dependent mechanism., [RefSeq, PubMed]; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 63, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70613;P70614;Q52KS0;Q62678;Q62836;Q64087;Q64128", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0015267 channel activity;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:2001171 positive regulation of ATP biosynthetic process;GO:0036466 synaptic vesicle recycling via endosome;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:2000302 positive regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53563-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35895-1", "uniprot_id": "GU03_RAT", "mass": 18666.0, "length": 168, "protein_name": "Putative gustatory receptor PTE03", "gene_name": "Olr1145; Or7g33c", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Olr1145; Or7g33c", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative gustatory receptor PTE03", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:300405)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29393594;8380780", "class_list": "", "function": "Possible taste receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35895-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11960-1", "uniprot_id": "ODBA_RAT", "mass": 50164.0, "length": 441, "protein_name": "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial", "gene_name": "Bckdha", "organism": "Rat", "refseq_name": "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial", "refseq_ac": "NP_036914", "gene_names_uniprotkb": "Bckdha", "gene_names_refseq": "BCKDA; Bckdha; E1a", "protein_names_uniprotkb": "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; 1.2.4.4; BCKDE1A; BCKDH E1-alpha; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain", "protein_names_refseq": "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; BCKDE1A; BCKDH E1-alpha; branched chain alpha-ketoacid dehydrogenase subunit E1 alpha; branched chain keto acid dehydrogenase subunit E1, alpha polypeptide; branched chain ketoacid dehydrogenase E1, alpha polypeptide; branched-chain alpha-keto acid dehydrogenase E1 component alpha chain", "tax_id": 10116, "disease": "maple syrup urine disease type IA (Disease Ontology:DOID:0061203); maple syrup urine disease (Disease Ontology:DOID:9269)", "pathway": " (rno:25244); (R-RNO-70895); (R-RNO-9859138)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "16396499;22673903;25193403;26035971;27213235;2822716;29779826;36802195", "class_list": "", "function": "Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts., [RefSeq, PubMed]; It has been found that NaBut reduces proliferation rate of ERasBcl (E1A, cHa-ras and bcl-2 ) cells significantly weaker than of ERas transformed cells, [RefSeq, PubMed]; Simvastatin stimulates liver BCKDH activity and BCAAs degradation in rats fed with the low protein diet., [RefSeq, PubMed]; Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.-;1.2.4.4;2.7.11.1;2.7.11.4;2.3.1.48;1.8.1.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0003863 branched-chain 2-oxo acid dehydrogenase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex", "go_biological_process": "GO:0007584 response to nutrient;GO:0051384 response to glucocorticoid;GO:0009083 branched-chain amino acid catabolic process;GO:0051591 response to cAMP;GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P11960-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08984-1", "uniprot_id": "LBR_RAT", "mass": 70724.0, "length": 620, "protein_name": "Delta(14)-sterol reductase LBR", "gene_name": "AABR07021955.1; Lbr", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AABR07021955.1; Lbr; AABR07021955.1; Lbr", "gene_names_refseq": "", "protein_names_uniprotkb": "Delta(14)-sterol reductase LBR; 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Delta-14-SR; Integral nuclear envelope inner membrane protein; Lamin-B receptor; NBP60; Sterol C14-reductase", "protein_names_refseq": "", "tax_id": 10116, "disease": "Greenberg dysplasia (Disease Ontology:DOID:0111588); primary biliary cholangitis (Disease Ontology:DOID:12236); ichthyosis vulgaris (Disease Ontology:DOID:1702); systemic lupus erythematosus (Disease Ontology:DOID:9074); Pelger-Huet anomaly (Disease Ontology:DOID:9631)", "pathway": " (R-RNO-2995383); (R-RNO-6807047); (R-RNO-8980692); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013408); (R-RNO-9013423); (R-RNO-9022692)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "12438562;16784888;9192729", "class_list": "", "function": "Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (By similarity). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;3.6.5.2;1.3.1.70;2.7.11.22;2.7.11.23;2.3.1.-;1.3.1.21;3.3.2.11", "go_molecular_function": "GO:0003677 DNA binding;GO:0051087 protein-folding chaperone binding;GO:0070402 NADPH binding;GO:0008139 nuclear localization sequence binding;GO:0070087 chromo shadow domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0060816 random inactivation of X chromosome;GO:0006695 cholesterol biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0036197 zymosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13838-1", "uniprot_id": "LEUK_RAT", "mass": 38426.0, "length": 378, "protein_name": "Leukosialin", "gene_name": "Spn", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Spn", "gene_names_refseq": "", "protein_names_uniprotkb": "Leukosialin; Leukocyte sialoglycoprotein; Sialophorin; W3/13 antigen", "protein_names_refseq": "", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24796); (R-RNO-202733); (R-RNO-210991)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11238599;22673903;2965006;9472040", "class_list": "", "function": "Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1., [UniProtKB, UniProtKB, UniProtKB]; Protects cells from apoptotic signals, promoting cell survival., [UniProtKB, UniProtKB]", "predicted_glycosites": 26, "predicted_n_glycosites": 0, "predicted_o_glycosites": 26, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 26, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0032154 cleavage furrow", "go_biological_process": "GO:0002296 T-helper 1 cell lineage commitment;GO:0001934 positive regulation of protein phosphorylation;GO:0007162 negative regulation of cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0042117 monocyte activation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P13838-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09015-1", "uniprot_id": "MXI1_RAT", "mass": 26022.0, "length": 228, "protein_name": "Max-interacting protein 1", "gene_name": "Mxi1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mxi1", "gene_names_refseq": "", "protein_names_uniprotkb": "Max-interacting protein 1; Max interactor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); breast adenocarcinoma (Disease Ontology:DOID:3458); neurofibrosarcoma (Disease Ontology:DOID:3512); esophageal cancer (Disease Ontology:DOID:5041)", "pathway": " (rno:25701)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0070443 Mad-Max complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0001825 blastocyst formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O09015-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04937-1", "uniprot_id": "FINC_RAT", "mass": 272511.0, "length": 2477, "protein_name": "Fibronectin", "gene_name": "Fn1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibronectin; FN", "protein_names_refseq": "", "tax_id": 10116, "disease": "calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); traumatic brain injury (Disease Ontology:DOID:0081292); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); spondylometaphyseal dysplasia corner fracture type (Disease Ontology:DOID:0112297); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); diabetic angiopathy (Disease Ontology:DOID:11713); iron deficiency anemia (Disease Ontology:DOID:11758); submandibular gland disease (Disease Ontology:DOID:12897); VACTERL association (Disease Ontology:DOID:14679); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:25661); (R-RNO-114608); (R-RNO-1474228); (R-RNO-1566977); (R-RNO-202733); (R-RNO-2129379); (R-RNO-216083); (R-RNO-3000170); (R-RNO-3000178); (R-RNO-354192); (R-RNO-354194); (R-RNO-372708); (R-RNO-381426); (R-RNO-5674135); (R-RNO-8874081); (R-RNO-8957275); (R-RNO-9634597); (R-RNO-9860927)", "pathway_count": 18, "publication_count": 10, "publication_id_list": "21454685;22673903;2445560;26479776;3119323;34502162;3863113;6089177;6317187;7519849", "class_list": "", "function": "Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 8, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 22, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q6LDX9", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0016504 peptidase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane;GO:0005577 fibrinogen complex", "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:1904385 cellular response to angiotensin;GO:0048484 enteric nervous system development;GO:0007044 cell-substrate junction assembly;GO:0007161 calcium-independent cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P04937-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35738-1", "uniprot_id": "ODBB_RAT", "mass": 42823.0, "length": 390, "protein_name": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial", "gene_name": "Bckdhb", "organism": "Rat", "refseq_name": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor", "refseq_ac": "NP_062140", "gene_names_uniprotkb": "Bckdhb", "gene_names_refseq": "BCKDE1B; Bckdhb", "protein_names_uniprotkb": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; 1.2.4.4; BCKDE1B; BCKDH E1-beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain", "protein_names_refseq": "2-oxoisovalerate dehydrogenase beta subunit; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; BCKDH E1-beta; branched chain keto acid dehydrogenase E1 beta; branched chain keto acid dehydrogenase E1, beta polypeptide; branched-chain alpha-keto acid dehydrogenase E1 component beta chain", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); chronic pancreatitis (Disease Ontology:DOID:0051065); maple syrup urine disease type IB (Disease Ontology:DOID:0061206); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Ehlers-Danlos syndrome arthrochalasia type 1 (Disease Ontology:DOID:0080727); osteogenesis imperfecta type 1 (Disease Ontology:DOID:0110334); osteogenesis imperfecta type 3 (Disease Ontology:DOID:0110339); osteogenesis imperfecta type 4 (Disease Ontology:DOID:0110340); osteogenesis imperfecta type 2 (Disease Ontology:DOID:0110341); osteoporosis (Disease Ontology:DOID:11476); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); beta thalassemia (Disease Ontology:DOID:12241); osteogenesis imperfecta (Disease Ontology:DOID:12347); alcoholic hepatitis (Disease Ontology:DOID:12351); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); cholestasis (Disease Ontology:DOID:13580); bladder neck obstruction (Disease Ontology:DOID:13948); thoracic aortic aneurysm (Disease Ontology:DOID:14004); aggressive periodontitis (Disease Ontology:DOID:1474); multiple sclerosis (Disease Ontology:DOID:2377); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); dermatofibrosarcoma protuberans (Disease Ontology:DOID:3507); pulmonary fibrosis (Disease Ontology:DOID:3770); dentinogenesis imperfecta (Disease Ontology:DOID:4154); systemic scleroderma (Disease Ontology:DOID:418); Caffey disease (Disease Ontology:DOID:4257); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); degenerative disc disease (Disease Ontology:DOID:90); cutaneous leishmaniasis (Disease Ontology:DOID:9111); liver benign neoplasm (Disease Ontology:DOID:916); maple syrup urine disease (Disease Ontology:DOID:9269); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29711); (R-RNO-70895); (R-RNO-9859138)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "1390893;25193403", "class_list": "", "function": "Simvastatin stimulates liver BCKDH activity and BCAAs degradation in rats fed with the low protein diet., [RefSeq, PubMed]; Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.-;1.2.4.4;2.7.11.1;2.7.11.4;2.3.1.48;1.8.1.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0003863 branched-chain 2-oxo acid dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex", "go_biological_process": "GO:0007584 response to nutrient;GO:0051384 response to glucocorticoid;GO:0009083 branched-chain amino acid catabolic process;GO:0051591 response to cAMP;GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35738-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28473-1", "uniprot_id": "GBRG3_RAT", "mass": 54293.0, "length": 467, "protein_name": "Gamma-aminobutyric acid receptor subunit gamma-3", "gene_name": "Gabrg3", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit gamma-3 precursor", "refseq_ac": "NP_077346", "gene_names_uniprotkb": "Gabrg3", "gene_names_refseq": "Gabrg3", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit gamma-3; GABA(A) receptor subunit gamma-3; GABAAR subunit gamma-3", "protein_names_refseq": "GABA(A) receptor subunit gamma-3; GABA-alpha receptor gamma-3 subunit; GABAAR subunit gamma-3; gamma-aminobutyric acid (GABA) A receptor, gamma 3; gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3; gamma-aminobutyric acid A receptor, gamma 3; gamma-aminobutyric acid receptor subunit gamma-3 precursor; gamma-aminobutyric acid receptor subunit gamma-3; gamma-aminobutyric acid type A receptor gamma 3 subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:79211); (R-RNO-977443)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10462548;1311098;1660002", "class_list": "", "function": "Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10462548, PubMed:1311098, PubMed:1660002). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient (PubMed:10462548, PubMed:1311098, PubMed:1660002)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;1.11.1.-;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0009410 response to xenobiotic stimulus;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P28473-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00773-1", "uniprot_id": "CELA1_RAT", "mass": 28976.0, "length": 266, "protein_name": "Chymotrypsin-like elastase family member 1", "gene_name": "Bin2; Cela1", "organism": "Rat", "refseq_name": "chymotrypsin-like elastase family member 1 precursor", "refseq_ac": "NP_036684", "gene_names_uniprotkb": "Bin2; Cela1; Bin2; Ela1", "gene_names_refseq": "Cela1; ELAI1; Ela1; RATELAI1", "protein_names_uniprotkb": "Chymotrypsin-like elastase family member 1; 3.4.21.36; Elastase-1", "protein_names_refseq": "chymotrypsin-like elastase family member 1 precursor; chymotrypsin-like elastase family, member 1; elastase 1, pancreatic; elastase-1", "tax_id": 10116, "disease": "centronuclear myopathy 2 (Disease Ontology:DOID:0111220)", "pathway": " (rno:24331)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14631510;14631512;6094548;6555050;6918221", "class_list": "", "function": "Data show that both cathepsin D and elastase are present in lysosomes of smooth-muscle cells, macrophages, and fibroblasts of the myometrium., [RefSeq, PubMed]; Results describe the location of elastase in rat uterus during its postpartum involution., [RefSeq, PubMed]; Serine proteases that hydrolyze many proteins in addition to elastin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region;GO:0001891 phagocytic cup;GO:0005938 cell cortex;GO:0042995 cell projection", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00773-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17164-1", "uniprot_id": "FUCO_RAT", "mass": 53487.0, "length": 462, "protein_name": "Tissue alpha-L-fucosidase", "gene_name": "Fuca1", "organism": "Rat", "refseq_name": "tissue alpha-L-fucosidase precursor", "refseq_ac": "NP_036694", "gene_names_uniprotkb": "Fuca1; Fuca", "gene_names_refseq": "Fuca1; Fuca", "protein_names_uniprotkb": "Tissue alpha-L-fucosidase; 3.2.1.51; Alpha-L-fucosidase 1; Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1", "protein_names_refseq": "Fucosidase, alpha-L-1, tissue; alpha-L-fucosidase I; alpha-L-fucoside fucohydrolase 1; fucosidase, alpha-L- 1, tissue; tissue alpha-L-fucosidase precursor; tissue alpha-L-fucosidase", "tax_id": 10116, "disease": "fucosidosis (Disease Ontology:DOID:14500); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24375); (R-RNO-6798695); (R-RNO-975578)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "2482732", "class_list": "glycogene;glycosylhydrolase", "function": "Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q642C6", "ec_number_list": "1.11.2.2;3.4.21.4;3.4.16.-;3.2.1.-;5.3.4.1;1.1.1.205;3.2.1.23;5.3.99.3;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.17;3.2.1.31;3.5.3.1;2.7.11.13;2.3.3.8;3.2.1.51;3.4.21.20;1.6.2.2;3.5.3.15;3.5.1.26;3.6.4.6;3.1.6.12;2.4.1.1;2.7.11.24;3.1.27.-;3.4.14.1;3.1.6.4;3.1.6.8;1.6.5.5;3.6.1.-;2.7.10.2;3.4.19.9;3.1.3.16;3.2.1.52;6.3.4.21;3.4.14.2", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0004560 alpha-L-fucosidase activity;GO:0015928 fucosidase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016139 glycoside catabolic process;GO:0006004 fucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P17164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88202-1", "uniprot_id": "LPP60_RAT", "mass": 60795.0, "length": 564, "protein_name": "60 kDa lysophospholipase", "gene_name": "Aspg", "organism": "Rat", "refseq_name": "60 kDa lysophospholipase", "refseq_ac": "NP_653351", "gene_names_uniprotkb": "Aspg", "gene_names_refseq": "Aspg", "protein_names_uniprotkb": "60 kDa lysophospholipase; 3.1.1.5; L-asparagine amidohydrolase; Lysophospholipase-transacylase; PAF acetylhydrolase; Platelet-activating factor acetylhydrolase", "protein_names_refseq": "60 kDa lysophospholipase; asparaginase homolog; lysophospholipase-transacylase; lysophospholipase", "tax_id": 10116, "disease": "", "pathway": " (rno:246266); (R-RNO-8963693)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10320809;8119970;9575212", "class_list": "", "function": "Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (PubMed:10320809, PubMed:8119970, PubMed:9575212). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (PubMed:10320809). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (PubMed:10320809)., [UniProtKB, PubMed, PubMed, PubMed]; Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities. Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4G088", "ec_number_list": "3.1.1.4;3.1.1.47;3.1.1.-;3.1.1.5;3.1.1.3;3.5.1.1;3.1.1.32;3.1.1.13;3.1.1.6;2.3.1.43;3.1.2.22;3.1.2.-;2.3.1.149;3.1.2.2;2.3.1.-;3.1.1.23;3.1.-.-;3.4.19.5", "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004067 asparaginase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "", "go_biological_process": "GO:0006528 asparagine metabolic process;GO:0016042 lipid catabolic process;GO:0006520 amino acid metabolic process;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88202-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11715-1", "uniprot_id": "CP17A_RAT", "mass": 57250.0, "length": 507, "protein_name": "Steroid 17-alpha-hydroxylase/17,20 lyase", "gene_name": "Cyp17a1", "organism": "Rat", "refseq_name": "steroid 17-alpha-hydroxylase/17,20 lyase", "refseq_ac": "NP_036885", "gene_names_uniprotkb": "Cyp17a1; Cyp17", "gene_names_refseq": "Cyp17a1; Cyp17", "protein_names_uniprotkb": "Steroid 17-alpha-hydroxylase/17,20 lyase; 1.14.14.19; 1.14.14.32; 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase", "protein_names_refseq": "17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450, subfamily XVII; P450-C17; P45017alpha; P450c17; cytochrome P450 17A1; cytochrome P450, subfamily 17; cytochrome P450-C17; cytochrome P450c17; steroid 17-alpha-hydroxylase/17,20 lyase; steroid 17-alpha-monooxygenase", "tax_id": 10116, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); cholelithiasis (Disease Ontology:DOID:10211); prostate cancer (Disease Ontology:DOID:10283); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); gallbladder cancer (Disease Ontology:DOID:3121)", "pathway": " (rno:25146); (R-RNO-193048); (R-RNO-194002)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1627653;22800812;24679120;2554289;2786990;3260774;3264499;3436956;7702752", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB]; Data suggest that CYP17A1 and aromatase/Cyp19a1 are induced in hippocampus by the environmental pollutant/retinoid X receptor agonist tributyltin; thus, tributyltin appears to stimulate estradiol biosynthesis., [RefSeq, PubMed]; These data demonstrate the occurrence of P450C(17) in the deep cerebellar nuclei of the rat, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68FY2;Q6LAE5", "ec_number_list": "1.14.14.25;1.14.14.1;1.14.14.19;1.14.14.32", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016829 lyase activity;GO:0004508 steroid 17-alpha-monooxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane;GO:0042995 cell projection", "go_biological_process": "GO:0021766 hippocampus development;GO:0031667 response to nutrient levels;GO:0071222 cellular response to lipopolysaccharide;GO:0008584 male gonad development;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P11715-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51489-1", "uniprot_id": "OPSD_RAT", "mass": 39042.0, "length": 348, "protein_name": "Rhodopsin", "gene_name": "Rho", "organism": "Rat", "refseq_name": "rhodopsin", "refseq_ac": "NP_254276", "gene_names_uniprotkb": "Rho", "gene_names_refseq": "Rho", "protein_names_uniprotkb": "Rhodopsin", "protein_names_refseq": "Rhodopsin (retinitis pigmentosa 4, autosomal dominant); rhodopsin", "tax_id": 10116, "disease": "brain glioma (Disease Ontology:DOID:0060108); immunodeficiency 90 (Disease Ontology:DOID:0061060); retinitis pigmentosa 4 (Disease Ontology:DOID:0110372); congenital stationary night blindness autosomal dominant 1 (Disease Ontology:DOID:0110862); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); fundus albipunctatus (Disease Ontology:DOID:11105); prostatic hypertrophy (Disease Ontology:DOID:11132); leukemia (Disease Ontology:DOID:1240); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); morphine dependence (Disease Ontology:DOID:2560); middle cerebral artery infarction (Disease Ontology:DOID:3525); night blindness (Disease Ontology:DOID:8499); acute myeloid leukemia (Disease Ontology:DOID:9119); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24717); (R-RNO-2453902); (R-RNO-2485179); (R-RNO-2514859); (R-RNO-418594); (R-RNO-419771); (R-RNO-5620916)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "23901245;26004531;26436889;28734946;34680161;7654522", "class_list": "", "function": "Allele-specific ASO-mediated knockdown of mutant P23H rhodopsin expression slowed the rate of photoreceptor degeneration and preserved the function of photoreceptor cells in eyes of the P23H rhodopsin transgenic rat., [RefSeq, PubMed]; EGF induces Ca(2+) sensitization in vascular smooth muscle by Rho-kinase-dependent inactivation of MLCP mediated by the EGF receptor/MEK/Erk1/2 pathway, [RefSeq, PubMed]; G protein-coupled photoreceptor that activates the G protein transducin (t) signaling pathway in response to light and is essential for image-forming vision under low-light conditions. Required for postnatal photoreceptor cell viability. Activation occurs when the covalently bound 11-cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers G protein-mediated phototransduction. Signal termination occurs via receptor phosphorylation, which promotes binding of arrestin (SAG) and displacement of the G protein alpha subunit., [UniProtKB, UniProtKB]; Pharmacological Inhibition of the VCP/Proteasome Axis Rescues Photoreceptor Degeneration in RHO(P23H) Rat Retinal Explants. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that retinoid metabolism in the eye is impaired in type 1 diabetes, which leads to deficient generation of visual pigments and neural retinal dysfunction in early diabetes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030507 spectrin binding;GO:0016918 retinal binding;GO:0005502 11-cis retinal binding;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0060342 photoreceptor inner segment membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0016038 absorption of visible light;GO:0009583 detection of light stimulus;GO:0006468 protein phosphorylation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51489-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54902-1", "uniprot_id": "NRAM2_RAT", "mass": 62277.0, "length": 568, "protein_name": "Natural resistance-associated macrophage protein 2", "gene_name": "Slc11a2", "organism": "Rat", "refseq_name": "natural resistance-associated macrophage protein 2 isoform 1", "refseq_ac": "NP_037305", "gene_names_uniprotkb": "Slc11a2; Dct1; Dmt1; Nramp2", "gene_names_refseq": "Dmt1; Nramp2; Slc11a2", "protein_names_uniprotkb": "Natural resistance-associated macrophage protein 2; DMT-1; Divalent cation transporter 1; Divalent metal transporter 1; NRAMP 2; Solute carrier family 11 member 2", "protein_names_refseq": "DMT-1; NRAMP 2; Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2); divalent cation transporter 1; divalent metal transporter 1; natural resistance-associated macrophage protein 2 isoform 1; natural resistance-associated macrophage protein 2; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2", "tax_id": 10116, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); Parkinsonism (Disease Ontology:DOID:0080855); iron deficiency anemia (Disease Ontology:DOID:11758); hypochromic anemia (Disease Ontology:DOID:11759); Parkinson's disease (Disease Ontology:DOID:14330); duodenal ulcer (Disease Ontology:DOID:1724); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pneumonia (Disease Ontology:DOID:552); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:25715); (R-RNO-425410); (R-RNO-917937)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16091957;22673903;24448823;28669019;29317744;37661197;37833459;9242408;9448300", "class_list": "", "function": "DMT1 mediates mitochondrial Fe2+ and Mn2+ acquisition. Publication Status: Online-Only, [RefSeq, PubMed]; HMGB1 Mediates Inflammation-Induced DMT1 Increase and Dopaminergic Neurodegeneration in the Early Stage of Parkinsonism., [RefSeq, PubMed]; Impaired intestinal expression of Dcyt-b and DMT-1 might be associated with the reduction of an iron uptake in CKD. Taken together, impaired these intestinal iron transporters may become a novel therapeutic target for cardio-renal anemia syndrome., [RefSeq, PubMed]; Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:16091957, PubMed:9242408). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (By similarity) (PubMed:16091957, PubMed:29317744, PubMed:9242408). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity) (PubMed:9242408). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (PubMed:29317744). Can mediate uncoupled fluxes of either protons or metal ions., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35172", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046870 cadmium ion binding;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005768 endosome", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0007611 learning or memory;GO:0010288 response to lead ion;GO:0001666 response to hypoxia;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O54902-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70260-1", "uniprot_id": "PIAS3_RAT", "mass": 68364.0, "length": 628, "protein_name": "E3 SUMO-protein ligase PIAS3", "gene_name": "Pias3", "organism": "Rat", "refseq_name": "E3 SUMO-protein ligase PIAS3 isoform 1", "refseq_ac": "NP_113972", "gene_names_uniprotkb": "Pias3", "gene_names_refseq": "Pias3", "protein_names_uniprotkb": "E3 SUMO-protein ligase PIAS3; 2.3.2.-; E3 SUMO-protein transferase PIAS3; KChAP; Potassium channel-associated protein; Protein inhibitor of activated STAT protein 3", "protein_names_refseq": "E3 SUMO-protein ligase PIAS3 isoform 1; E3 SUMO-protein ligase PIAS3; E3 SUMO-protein transferase PIAS3; potassium channel regulatory protein KChAP; potassium channel-associated protein; protein inhibitor of activated STAT protein 3", "tax_id": 10116, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (rno:83614); (R-RNO-3232118); (R-RNO-3899300); (R-RNO-4090294); (R-RNO-4615885); (R-RNO-4755510); (R-RNO-5696395)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "11709556;11997457;30942400;31642335;34288124;9565597", "class_list": "", "function": "Activity-Induced SUMOylation of Neuronal Nitric Oxide Synthase Is Associated with Plasticity of Synaptic Transmission and Extracellular Signal-Regulated Kinase 1/2 Signaling., [RefSeq, PubMed]; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1. Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Neuronal activity-induced SUMOylation of Akt1 by PIAS3 is required for long-term potentiation of synaptic transmission., [RefSeq, PubMed]; YB1 interacts with and promotes PIAS3 mRNA decay to facilitate STAT3 phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.32;5.6.2.3;2.4.2.-;2.3.2.27;2.7.11.1;2.3.2.-;2.4.2.30;3.4.21.-;5.6.2.4;1.14.11.-", "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70260-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14740-1", "uniprot_id": "DPP4_RAT", "mass": 88089.0, "length": 767, "protein_name": "Dipeptidyl peptidase 4", "gene_name": "Dpp4", "organism": "Rat", "refseq_name": "dipeptidyl peptidase 4", "refseq_ac": "NP_036921", "gene_names_uniprotkb": "Dpp4; Cd26", "gene_names_refseq": "CD26; DPPIV; Dpp4", "protein_names_uniprotkb": "Dipeptidyl peptidase 4; 3.4.14.5; Bile canaliculus domain-specific membrane glycoprotein; DPP IV; Dipeptidyl peptidase IV 60 kDa soluble form; Dipeptidyl peptidase IV membrane form; Dipeptidyl peptidase IV soluble form; Dipeptidyl peptidase IV; GP110 glycoprotein; T-cell activation antigen CD26", "protein_names_refseq": "DPP IV; GP110 glycoprotein; T-cell activation antigen CD26; bile canaliculus domain-specific membrane glycoprotein; dipeptidyl peptidase 4; dipeptidyl peptidase IV", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); autism spectrum disorder (Disease Ontology:DOID:0060041); blepharocheilodontic syndrome 2 (Disease Ontology:DOID:0080346); Middle East respiratory syndrome (Disease Ontology:DOID:0080642); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary hypertension (Disease Ontology:DOID:6432); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25253); (R-RNO-381771); (R-RNO-400511)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "1347701;16768443;1970322;1974258;19804410;21454685;2563382;3182821;32542696;33162819;34310895;34738744;3479775;35014677;7905271;9210490", "class_list": "", "function": "Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Also acts as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline., [UniProtKB, UniProtKB]; Dipeptidyl Peptidase-4 deficiency effectively protects the brain and neurological function in rodent after acute Hemorrhagic Stroke. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of dipeptidyl peptidase-4 averts free fatty acids deposition in the hearts of oral estrogen-progestin contraceptive-induced hyperinsulinemic female rats., [RefSeq, PubMed]; Knockdown of DPP4 promotes the proliferation and the activation of the CREB/aromatase pathway in ovarian granulosa cells., [RefSeq, PubMed]; MiR-448-3p alleviates diabetic vascular dysfunction by inhibiting endothelial-mesenchymal transition through DPP-4 dysregulation., [RefSeq, PubMed]; Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate Senescent Cells via DPP4 Targeting and PARP1 Activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 3, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.14.5", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0002020 protease binding;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0045121 membrane raft", "go_biological_process": "GO:0002717 positive regulation of natural killer cell mediated immunity;GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P14740-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12527-1", "uniprot_id": "LOX5_RAT", "mass": 78087.0, "length": 673, "protein_name": "Polyunsaturated fatty acid 5-lipoxygenase", "gene_name": "Alox5", "organism": "Rat", "refseq_name": "polyunsaturated fatty acid 5-lipoxygenase", "refseq_ac": "NP_036954", "gene_names_uniprotkb": "Alox5", "gene_names_refseq": "5-LOX; Alox5; LOX5A", "protein_names_uniprotkb": "Polyunsaturated fatty acid 5-lipoxygenase; 1.13.11.-; 1.13.11.34; 5-LO; 5-lipoxygenase; Arachidonate 5-lipoxygenase", "protein_names_refseq": "5 - Lipoxygenase; 5-LO; 5-lipoxygenase; polyunsaturated fatty acid 5-lipoxygenase", "tax_id": 10116, "disease": "exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); pleurisy (Disease Ontology:DOID:10247); common cold (Disease Ontology:DOID:10459); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); pulmonary edema (Disease Ontology:DOID:11396); nephrotic syndrome (Disease Ontology:DOID:1184); pancreatic cancer (Disease Ontology:DOID:1793); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); pulmonary fibrosis (Disease Ontology:DOID:3770); cholangiocarcinoma (Disease Ontology:DOID:4947); pulmonary hypertension (Disease Ontology:DOID:6432); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (rno:25290); (R-RNO-2142688); (R-RNO-2142691); (R-RNO-2142700); (R-RNO-6798695); (R-RNO-9018676); (R-RNO-9018682); (R-RNO-9018896); (R-RNO-9020265); (R-RNO-9023661); (R-RNO-9026286); (R-RNO-9026290); (R-RNO-9026403); (R-RNO-9027604)", "pathway_count": 14, "publication_count": 5, "publication_id_list": "18714024;3417684;36395739;37385102;8518276", "class_list": "", "function": "Catalyzes the oxygenation of arachidonate to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation. Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene. Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (By similarity). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers. In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes. Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40. May also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK. Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodeling., [RefSeq, PubMed]; MALAT1 binds to miR-188-3p to regulate ALOX5 activity in the lung inflammatory response of neonatal bronchopulmonary dysplasia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.8;1.1.1.205;1.13.11.-;1.13.11.31;3.2.1.23;3.5.4.5;2.3.2.5;3.6.4.13;2.4.1.25;3.2.1.33;4.2.99.18;5.6.2.4;1.13.11.33;4.1.2.4;2.4.1.186;3.5.4.6;3.1.1.47;2.7.1.35;3.4.22.1;1.11.1.6;2.5.1.18;4.1.2.13;3.6.5.-;4.2.1.24;3.2.1.31;2.4.1.1;2.7.10.2;2.7.11.1;2.7.1.40;1.13.11.34;3.4.19.1;2.3.3.8;1.16.3.1;2.7.4.6;2.7.13.3;3.4.23.5;5.4.2.11;5.4.2.4;2.7.1.1;3.3.2.6;3.4.11.4;2.7.1.11;5.3.2.1;5.3.3.12;3.4.21.46;3.1.6.4;2.4.2.7;5.4.2.2;1.1.1.42;3.6.4.6;3.4.24.35;3.1.6.12;2.3.2.26;3.6.4.10;2.7.11.24;2.4.2.1;3.4.22.52;1.13.11.12;3.4.22.27;2.7.11.39;5.3.1.9;5.1.3.-;3.5.1.23;3.5.1.-;3.6.1.6;4.4.1.20;2.5.1.-;3.4.25.1;3.4.18.1;1.11.1.24", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016787 hydrolase activity;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0036403 arachidonate 8(S)-lipoxygenase activity;GO:0004051 arachidonate 5-lipoxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005641 nuclear envelope lumen;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0034440 lipid oxidation;GO:0061044 negative regulation of vascular wound healing;GO:2001301 lipoxin biosynthetic process;GO:0006954 inflammatory response;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P12527-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35078-1", "uniprot_id": "OXDA_RAT", "mass": 38820.0, "length": 346, "protein_name": "D-amino-acid oxidase", "gene_name": "Dao", "organism": "Rat", "refseq_name": "D-amino-acid oxidase", "refseq_ac": "NP_446078", "gene_names_uniprotkb": "Dao; Dao1", "gene_names_refseq": "Dao1; Dao", "protein_names_uniprotkb": "D-amino-acid oxidase; 1.4.3.3; DAAO; DAMOX; DAO", "protein_names_refseq": "D-amino acid oxidase 1; D-amino-acid oxidase; DAAO; DAMOX", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:114027); (R-RNO-389661); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "17880399;19438227;20564560;21700703;21981077;23631755;24138986;25001371;26961980;2896644;32512180;33319325;37289348;38044118;7903300;9473656", "class_list": "", "function": "Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity (PubMed:21700703, PubMed:21981077). Required to catabolize D-amino acids synthesized endogenously, of gastrointestinal bacterial origin or obtained from the diet, and to use these as nutrients (By similarity). Regulates the level of D-amino acid neurotransmitters in the brain, such as D-serine, a co-agonist of N-methyl D-aspartate (NMDA) receptors, and may modulate synaptic transmission (PubMed:23631755). Catalyzes the first step of the racemization of D-DOPA to L-DOPA, for possible use in an alternative dopamine biosynthesis pathway (By similarity). Also catalyzes the first step of the chiral inversion of N(gamma)-nitro-D-arginine methyl ester (D-NNA) to its L-enantiomer L-NNA that acts as a nitric oxide synthase inhibitor (By similarity). The hydrogen peroxide produced in the reaction provides protection against microbial infection; it contributes to the oxidative killing activity of phagocytic leukocytes and protects against bacterial colonization of the small intestine (By similarity). Enzyme secreted into the lumen of the intestine may not be catalytically active and could instead be proteolytically cleaved into peptides with antimicrobial activity (By similarity). The hydrogen peroxide produced in the reaction may also play a role in promoting cellular senescence in response to DNA damage (By similarity). Could act as a detoxifying agent which removes D-amino acids accumulated during aging (PubMed:7903300)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; D-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats., [RefSeq, PubMed]; Evaluation of D-amino acid oxidase activity in rat kidney using a D-kynurenine derivative, 6-methylthio-D-kynurenine: An in vivo microdialysis study., [RefSeq, PubMed]; Its toxic effect on motor neurons can be mediated by expression in motor neurons and it promotes autophagy., [RefSeq, PubMed]; Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.3.15;1.2.3.5;3.4.21.-;2.3.2.27;1.4.3.1;1.4.3.3;3.1.2.2;3.1.2.-;1.11.1.6;1.3.3.6;2.6.1.51;2.6.1.44;2.3.1.137;2.3.1.176;2.3.1.16;2.3.1.155;2.3.2.36;2.5.1.18;3.4.24.56;1.1.1.42;5.1.99.4;4.1.3.4;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;1.14.13.39;3.4.21.53;5.3.3.8;5.3.3.21;3.1.2.27;2.3.1.65;3.6.1.-;3.6.1.77;2.3.1.7;4.1.2.63;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;1.1.1.300;1.1.1.184;4.1.1.9;2.3.1.42;1.3.1.38;2.7.4.6;1.3.1.124", "go_molecular_function": "GO:0042802 identical protein binding;GO:0071949 FAD binding;GO:0003884 D-amino-acid oxidase activity;GO:0008718 D-amino-acid dehydrogenase activity;GO:0043799 glycine oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0070945 neutrophil-mediated killing of gram-negative bacterium;GO:0019478 D-amino acid catabolic process;GO:0036088 D-serine catabolic process;GO:0055130 D-alanine catabolic process;GO:0070178 D-serine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35078-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97629-1", "uniprot_id": "LCAP_RAT", "mass": 117201.0, "length": 1025, "protein_name": "Leucyl-cystinyl aminopeptidase", "gene_name": "Lnpep", "organism": "Rat", "refseq_name": "leucyl-cystinyl aminopeptidase", "refseq_ac": "NP_001106874", "gene_names_uniprotkb": "Lnpep; Irap; LOC100912445; Otase", "gene_names_refseq": "GP160; IRAP; Lnpep; OTase; P-LAP; Vp165", "protein_names_uniprotkb": "Leucyl-cystinyl aminopeptidase; 3.4.11.3; Cystinyl aminopeptidase; GP160; IRAP; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; OTase; Oxytocinase; P-LAP; Placental leucine aminopeptidase; Vesicle protein of 165 kDa; Vp165", "protein_names_refseq": "aminopeptidase Vp165; angiotensin IV receptor; cystinyl aminopeptidase; insulin-regulated membrane aminopeptidase IRAP; insulin-responsive aminopeptidase; leucyl-cystinyl aminopeptidase-like; leucyl-cystinyl aminopeptidase; leucyl/cystinyl aminopeptidase; oxytocinase; placental leucine aminopeptidase; vesicle protein of 165 kDa", "tax_id": 10116, "disease": "leiomyoma (Disease Ontology:DOID:127); severe pre-eclampsia (Disease Ontology:DOID:13129); breast cancer (Disease Ontology:DOID:1612); renal cell carcinoma (Disease Ontology:DOID:4450); polyhydramnios (Disease Ontology:DOID:8488); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:171105); (R-RNO-1236977); (R-RNO-983168)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12061804;21454685;26006037;26311777;27038740;28356324;29393594;38843836;7559527;8119954", "class_list": "", "function": "Acute inhibition of IRAP aminopeptidase activity does not affect glucose homeostasis., [RefSeq, PubMed]; Ang IV protects myocardial injury against reperfusion by inhibiting inflammation and apoptosis via AT4R and PI3K-Akt-mTOR signaling pathway in anesthetized rats., [RefSeq, PubMed]; IRAP is involved in vesicular trafficking and shares common regional distribution with the sst2A receptor in the hippocampus., [RefSeq, PubMed]; Release of an N-terminal amino acid, cleave before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sol and MB CysAP activities, acting separately or in concert and mainly in renal medulla, regulate the function of their susceptible endogenous substrates, and may participate meaningfully in the control of blood pressure and fluid balance., [RefSeq, PubMed]", "predicted_glycosites": 18, "predicted_n_glycosites": 17, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "Q11009", "ec_number_list": "3.4.11.-;3.4.11.14;3.4.22.40;3.4.11.3;3.4.14.10", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0045777 positive regulation of blood pressure;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0008217 regulation of blood pressure;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97629-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84060-1", "uniprot_id": "DTNB_RAT", "mass": 73878.0, "length": 654, "protein_name": "Dystrobrevin beta", "gene_name": "Dtnb", "organism": "Rat", "refseq_name": "dystrobrevin beta isoform X5", "refseq_ac": "XP_038968415", "gene_names_uniprotkb": "Dtnb", "gene_names_refseq": "Dtnb", "protein_names_uniprotkb": "Dystrobrevin beta; Beta-dystrobrevin; DTN-B", "protein_names_refseq": "dystrobrevin beta isoform X5", "tax_id": 10116, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (R-RNO-9913351)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10545507;14600269;17265465;22673903;8889548", "class_list": "", "function": "Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q66HF4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0030182 neuron differentiation;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P84060-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55108-1", "uniprot_id": "GDF10_RAT", "mass": 52961.0, "length": 476, "protein_name": "Growth/differentiation factor 10", "gene_name": "Gdf10", "organism": "Rat", "refseq_name": "growth/differentiation factor 10 precursor", "refseq_ac": "NP_077351", "gene_names_uniprotkb": "Gdf10; Bmp3b", "gene_names_refseq": "Gdf10", "protein_names_uniprotkb": "Growth/differentiation factor 10; BIP; BMP-3B; Bone morphogenetic protein 3B; Bone-inducing protein; GDF-10", "protein_names_refseq": "BIP; BMP-3b; GDF-10; bone morphogenetic protein 3b; bone-inducing protein; growth/differentiation factor 10 precursor; prepro bone inducing protein", "tax_id": 10116, "disease": "", "pathway": " (rno:79216)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26811051;28394782;36714584;8605043", "class_list": "", "function": "Findings indicate that the attenuation of REV-ERBalpha leads to an upregulation of Gdf10 and Gdf15 in decidual cells, [RefSeq, PubMed]; Growth differentiation factor 10 induces angiogenesis to promote wound healing in rats with diabetic foot ulcers by activating TGF-beta1/Smad3 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis., [UniProtKB, UniProtKB]; Results suggest that the decreasing growth and differentiation factor 10 may contribute toward neuropathic pain by facilitating N-methyl-D-aspartate receptor activation. Findings shed new light on the understanding of the molecular mechanisms underlying neuropathic pain., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0045444 fat cell differentiation;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0030278 regulation of ossification;GO:0045669 positive regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55108-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08654-1", "uniprot_id": "PHAF1_RAT", "mass": 47463.0, "length": 422, "protein_name": "Phagosome assembly factor 1", "gene_name": "Phaf1", "organism": "Rat", "refseq_name": "phagosome assembly factor 1", "refseq_ac": "NP_620609", "gene_names_uniprotkb": "Phaf1; RGD621098", "gene_names_refseq": "Lin-10; Lin10; Phaf1; RGD621098", "protein_names_uniprotkb": "Phagosome assembly factor 1", "protein_names_refseq": "UPF0183 protein C16orf70 homolog; lin-10 homolog; phagosome assembly factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:207123)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14529721;9480860", "class_list": "", "function": "Lin-10 is enriched in the trans-Golgi network and present in dendrites and spines of whole brain and cultured neurons--where protein sorting and synaptic delivery are known to occur--suggesting that Lin-10 may regulate AMPA receptor trafficking in vivo., [RefSeq, PubMed]; Plays a regulatory role in autophagic activity. In complex with BCAS3, associates with the autophagosome formation site during both non-selective and selective autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0035254 glutamate receptor binding", "go_cellular_component": "GO:0030425 dendrite;GO:0030672 synaptic vesicle membrane;GO:0005802 trans-Golgi network;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0043001 Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08654-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05369-1", "uniprot_id": "FPPS_RAT", "mass": 40830.0, "length": 353, "protein_name": "Farnesyl pyrophosphate synthase", "gene_name": "Fdps; Rusc1", "organism": "Rat", "refseq_name": "farnesyl pyrophosphate synthase", "refseq_ac": "NP_114028", "gene_names_uniprotkb": "Fdps; Rusc1; LOC100360417", "gene_names_refseq": "Ac2-125; FPS; Fdps", "protein_names_uniprotkb": "Farnesyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; 2.5.1.10; 2.5.1.1; CR 39; Cholesterol-regulated 39 kDa protein; Dimethylallyltranstransferase; FPP synthase; FPS; Farnesyl diphosphate synthase; Geranyltranstransferase", "protein_names_refseq": "(2E,6E)-farnesyl diphosphate synthase; CR 39; FPP synthase; FPP synthetase; cholesterol-regulated 39 kDa protein; dimethylallyltranstransferase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; geranyltranstransferase; testis-specific farnesyl pyrophosphate synthetase", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (rno:100360417); (rno:83791); (R-RNO-9969896)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "19800872;2325654;24527834;25847782;3670308", "class_list": "", "function": "Data indicate that FPPS may play an important role in Ang II-induced fibrotic responses in VSMCs, [RefSeq, PubMed]; Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis in vitro., [RefSeq, PubMed]; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This is the first report to show that chronic inhibition of farnesyl pyrophosphate synthase attenuates the development of cardiac hypertrophy and fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GT82", "ec_number_list": "2.5.1.1;2.5.1.10;2.5.1.29;2.5.1.-", "go_molecular_function": "GO:0004161 dimethylallyltranstransferase activity;GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity;GO:0046872 metal ion binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0005769 early endosome", "go_biological_process": "GO:0033384 geranyl diphosphate biosynthetic process;GO:0045337 farnesyl diphosphate biosynthetic process;GO:0007283 spermatogenesis;GO:0006695 cholesterol biosynthetic process;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P05369-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60815-1", "uniprot_id": "FLVC2_RAT", "mass": 59742.0, "length": 546, "protein_name": "Choline/ethanolamine transporter FLVCR2", "gene_name": "Flvcr2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Flvcr2", "gene_names_refseq": "", "protein_names_uniprotkb": "Choline/ethanolamine transporter FLVCR2; CCT; Calcium-chelate transporter; Feline leukemia virus subgroup C receptor-related protein 2; Heme transporter FLVCR2", "protein_names_refseq": "", "tax_id": 10116, "disease": "proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Disease Ontology:DOID:0111666)", "pathway": " (rno:314323)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14729055", "class_list": "", "function": "Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier. Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain (By similarity). Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine (By similarity). Also mediates transport of ethanolamine (By similarity). Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane (By similarity). However, the presence of an inwardly directed proton gradient enhances choline uptake (By similarity). Also acts as a heme b transporter (By similarity). Required to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis (By similarity). At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis (By similarity). Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0033265 choline binding;GO:0015232 heme transmembrane transporter activity;GO:0020037 heme binding;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097102 endothelial tip cell fate specification;GO:0001701 in utero embryonic development;GO:0030324 lung development;GO:0007420 brain development;GO:0002040 sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60815-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11466-1", "uniprot_id": "OCTC_RAT", "mass": 70302.0, "length": 612, "protein_name": "Peroxisomal carnitine O-octanoyltransferase", "gene_name": "Crot", "organism": "Rat", "refseq_name": "peroxisomal carnitine O-octanoyltransferase", "refseq_ac": "NP_114193", "gene_names_uniprotkb": "Crot; Cot", "gene_names_refseq": "Crot", "protein_names_uniprotkb": "Peroxisomal carnitine O-octanoyltransferase; 2.3.1.137; COT", "protein_names_refseq": "COT; peroxisomal carnitine O-octanoyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:83842); (R-RNO-389887); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11553629;15155769;29393594;3233218;7495866", "class_list": "", "function": "Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P48033", "ec_number_list": "1.1.3.15;1.2.3.5;3.4.21.-;2.3.2.27;1.4.3.1;1.4.3.3;3.1.2.2;3.1.2.-;1.11.1.6;1.3.3.6;2.6.1.51;2.6.1.44;2.3.1.137;2.3.1.176;2.3.1.16;2.3.1.155;2.3.1.21;2.3.2.36;2.5.1.18;3.4.24.56;1.1.1.42;5.1.99.4;4.1.3.4;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;1.14.13.39;3.4.21.53;5.3.3.8;5.3.3.21;3.1.2.27;2.3.1.65;3.6.1.-;3.6.1.77;2.3.1.7;4.1.2.63;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;1.1.1.300;1.1.1.184;4.1.1.9;2.3.1.42;1.3.1.38;2.7.4.6;1.3.1.124", "go_molecular_function": "GO:0008458 carnitine O-octanoyltransferase activity;GO:0016406 carnitine O-acyltransferase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0071874 cellular response to norepinephrine stimulus;GO:0051791 medium-chain fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P11466-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70553-1", "uniprot_id": "NRAM1_RAT", "mass": 55922.0, "length": 507, "protein_name": "Natural resistance-associated macrophage protein 1", "gene_name": "Slc11a1", "organism": "Rat", "refseq_name": "natural resistance-associated macrophage protein 1 isoform 2", "refseq_ac": "NP_001026828", "gene_names_uniprotkb": "Slc11a1; Bcg; Nramp1", "gene_names_refseq": "Bcg; Itg; Lsh; Nramp1; Slc11a1", "protein_names_uniprotkb": "Natural resistance-associated macrophage protein 1; NRAMP 1; Solute carrier family 11 member 1", "protein_names_refseq": "NRAMP 1; natural resistance-associated macrophage protein 1 isoform 2; natural resistance-associated macrophage protein 1; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1", "tax_id": 10116, "disease": "Buruli ulcer disease (Disease Ontology:DOID:0050456); inflammatory bowel disease (Disease Ontology:DOID:0050589); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); leprosy (Disease Ontology:DOID:1024); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoidosis (Disease Ontology:DOID:11335); Behcet's disease (Disease Ontology:DOID:13241); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); gastrointestinal system disease (Disease Ontology:DOID:77); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); visceral leishmaniasis (Disease Ontology:DOID:9146); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:316519); (R-RNO-1222556); (R-RNO-425410); (R-RNO-6798695); (R-RNO-6803544)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "8875897", "class_list": "", "function": "Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q496Z6", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005384 manganese ion transmembrane transporter activity;GO:0046915 transition metal ion transmembrane transporter activity;GO:0051139 metal cation:proton antiporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0070821 tertiary granule membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0032496 response to lipopolysaccharide;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P70553-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VGK4-1", "uniprot_id": "GDPD1_RAT", "mass": 35811.0, "length": 314, "protein_name": "Lysophospholipase D GDPD1", "gene_name": "Gdpd1", "organism": "Rat", "refseq_name": "lysophospholipase D GDPD1", "refseq_ac": "NP_001037703", "gene_names_uniprotkb": "Gdpd1", "gene_names_refseq": "Gdpd1; RGD1311813", "protein_names_uniprotkb": "Lysophospholipase D GDPD1; 3.1.4.-; Glycerophosphodiester phosphodiesterase 4; Glycerophosphodiester phosphodiesterase domain-containing protein 1", "protein_names_refseq": "glycerophosphodiester phosphodiesterase 4; glycerophosphodiester phosphodiesterase domain-containing protein 1; lysophospholipase D GDPD1", "tax_id": 10116, "disease": "", "pathway": " (rno:303407)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis from both N-acyl-lysoplasmenylethanolamin (N-acyl-lysoPlsEt) and N-acyl-lysophosphatidylethanolamin (N-acyl-lysoPE). In addition, hydrolyzes glycerophospho-N-acylethanolamine to N-acylethanolamine. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.-;3.1.4.39;3.1.4.4;3.1.4.54;3.1.4.44", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0070291 N-acylethanolamine metabolic process;GO:0046475 glycerophospholipid catabolic process;GO:0006644 phospholipid metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VGK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88881-1", "uniprot_id": "BEGIN_RAT", "mass": 66993.0, "length": 611, "protein_name": "Brain-enriched guanylate kinase-associated protein", "gene_name": "Begain", "organism": "Rat", "refseq_name": "brain-enriched guanylate kinase-associated protein isoform 1", "refseq_ac": "NP_001104585", "gene_names_uniprotkb": "Begain", "gene_names_refseq": "Begain", "protein_names_uniprotkb": "Brain-enriched guanylate kinase-associated protein", "protein_names_refseq": "brain-enriched guanylate kinase-associated protein isoform 1; brain-enriched guanylate kinase-associated protein", "tax_id": 10116, "disease": "", "pathway": " (rno:79146)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;9756850", "class_list": "", "function": "May sustain the structure of the postsynaptic density (PSD)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88882", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0098817 evoked excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88881-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70156-1", "uniprot_id": "OLR1_RAT", "mass": 41890.0, "length": 364, "protein_name": "Oxidized low-density lipoprotein receptor 1", "gene_name": "Olr1", "organism": "Rat", "refseq_name": "oxidized low-density lipoprotein receptor 1", "refseq_ac": "NP_579840", "gene_names_uniprotkb": "Olr1; Lox1; Oldlr1", "gene_names_refseq": "LOX-1; Oldlr1; Oldr1; Olr1", "protein_names_uniprotkb": "Oxidized low-density lipoprotein receptor 1; LOX-1; Lectin-like oxLDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-type oxidized LDL receptor 1; Ox-LDL receptor 1", "protein_names_refseq": "Lectin-like oxidized low-density lipoprotein receptor-1; lectin-like oxLDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-like oxidized low-density lipoprotein receptor; lectin-type oxidized LDL receptor 1; ox-LDL receptor 1; oxidised low density lipoprotein (lectin-like) receptor 1; oxidized low density lipoprotein (lectin-like) receptor 1; oxidized low-density lipoprotein receptor 1", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)", "pathway": " (rno:140914); (R-RNO-202733); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12095612;12538855;33964218;35333694;37268943;38244081;38501247;9494115;9837956", "class_list": "", "function": "Expression pattern of LOX1-R in brain microvessels endothelial cells and its modulation by astrocytes, [RefSeq, PubMed]; Knockdown of lectin-like oxidized low-density lipoprotein-1 ameliorates alcoholic cardiomyopathy via inactivating the p38 mitogen-activated protein kinase pathway., [RefSeq, PubMed]; LOX-1 and MMP-9 Inhibition Attenuates the Detrimental Effects of Delayed rt-PA Therapy and Improves Outcomes After Acute Ischemic Stroke., [RefSeq, PubMed]; LOX-1 mediates inflammatory activation of microglial cells through the p38-MAPK/NF-kappaB pathways under hypoxic-ischemic conditions. Publication Status: Online-Only, [RefSeq, PubMed]; LOX-1 regulation of H-type vascular endothelial cell regeneration in hyperglycemia., [RefSeq, PubMed]; Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1-Related Microglial Activation in Neonatal Hypoxic-Ischemic Encephalopathy: Morphologic Consideration., [RefSeq, PubMed]; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0005041 low-density lipoprotein particle receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045121 membrane raft", "go_biological_process": "GO:0006954 inflammatory response;GO:0032930 positive regulation of superoxide anion generation;GO:0042157 lipoprotein metabolic process;GO:0042542 response to hydrogen peroxide;GO:0007159 leukocyte cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O70156-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89000-1", "uniprot_id": "DPYD_RAT", "mass": 111468.0, "length": 1025, "protein_name": "Dihydropyrimidine dehydrogenase [NADP(+)]", "gene_name": "Dpyd", "organism": "Rat", "refseq_name": "dihydropyrimidine dehydrogenase [NADP(+)]", "refseq_ac": "NP_112289", "gene_names_uniprotkb": "Dpyd; DPD", "gene_names_refseq": "Dpyd", "protein_names_uniprotkb": "Dihydropyrimidine dehydrogenase [NADP(+)]; 1.3.1.2; DHPDHase; DPD; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase", "protein_names_refseq": "DHPDHase; DPD; dihydropyrimidine dehydrogenase [NADP(+)]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase", "tax_id": 10116, "disease": "dihydropyrimidine dehydrogenase deficiency (Disease Ontology:DOID:14218); pancreatic cancer (Disease Ontology:DOID:1793); gallbladder cancer (Disease Ontology:DOID:3121); liver disease (Disease Ontology:DOID:409); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:81656); (R-RNO-73621)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9819714", "class_list": "", "function": "Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine., [UniProtKB, UniProtKB]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.1.2", "go_molecular_function": "GO:0002058 uracil binding;GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity;GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046079 dUMP catabolic process;GO:0006145 purine nucleobase catabolic process;GO:0006208 pyrimidine nucleobase catabolic process;GO:0006210 thymine catabolic process;GO:0006212 uracil catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O89000-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70444-1", "uniprot_id": "PIM3_RAT", "mass": 36002.0, "length": 326, "protein_name": "Serine/threonine-protein kinase pim-3", "gene_name": "Pim3", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase pim-3", "refseq_ac": "NP_072124", "gene_names_uniprotkb": "Pim3; Kid1", "gene_names_refseq": "Pim3", "protein_names_uniprotkb": "Serine/threonine-protein kinase pim-3; 2.7.11.1; Kinase induced by depolarization; Protein kinase Kid-1", "protein_names_refseq": "kinase induced by depolarization; pim-3 oncogene; protein kinase Kid-1; proviral integration site 3; serine threonine kinase pim3; serine threonine kinase-like; serine/threonine-protein kinase pim-3", "tax_id": 10116, "disease": "", "pathway": " (rno:64534)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19229879;19505587;21181358;26269675;28214201;38148455;9632723", "class_list": "", "function": "Anoxic preconditioning could act to protect the heart from anoxia/reoxygenation injury with cooperation from the proto-oncogene Pim-3; in addition, it up-regulates Pim-3 expression through a p38 MAPK signaling pathway., [RefSeq, PubMed]; Ischemia-reperfusion injury up-regulated Pim-3 gene expression through oxidative stress signaling pathway in myocardial tissues., [RefSeq, PubMed]; Our study suggests that up-regulation of Pim-3 successfully accelerated Chronic Obstructive Pulmonary Disease development, and aggravated lung damage, [RefSeq, PubMed]; Overexpression of pim-3 plays a protective role in LPS-stimulated hepatic stellate cells., [RefSeq, PubMed]; PIM3 regulates myocardial ischemia/reperfusion injury via ferroptosis., [RefSeq, PubMed]; Pim-3 is expressed in endothelial cells and promotes vascular tube formation., [RefSeq, PubMed]; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation., [UniProtKB, UniProtKB]; Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:1904322 cellular response to forskolin;GO:0007346 regulation of mitotic cell cycle;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O70444-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30823-1", "uniprot_id": "CTR1_RAT", "mass": 67267.0, "length": 624, "protein_name": "High affinity cationic amino acid transporter 1", "gene_name": "Slc7a1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Slc7a1; Atrc1", "gene_names_refseq": "", "protein_names_uniprotkb": "High affinity cationic amino acid transporter 1; CAT-1; CAT1; EcoR; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; Solute carrier family 7 member 1; System Y+ basic amino acid transporter", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-352230)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10196347;29393594;8473910", "class_list": "", "function": "(Microbial infection) Acts as a receptor for the ecotropic murine retroviral leukemia virus., [UniProtKB, PubMed]; High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000064 L-ornithine transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0001618 virus receptor activity;GO:0015174 basic amino acid transmembrane transporter activity;GO:0015189 L-lysine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015802 basic amino acid transport;GO:0042102 positive regulation of T cell proliferation;GO:0032006 regulation of TOR signaling;GO:0097638 L-arginine import across plasma membrane;GO:0015819 lysine transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P30823-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22717-1", "uniprot_id": "GCYB2_RAT", "mass": 76197.0, "length": 682, "protein_name": "Guanylate cyclase soluble subunit beta-2", "gene_name": "Gucy1b2", "organism": "Rat", "refseq_name": "guanylate cyclase soluble subunit beta-2 isoform 1", "refseq_ac": "NP_001257640", "gene_names_uniprotkb": "Gucy1b2", "gene_names_refseq": "Gucy1b2a; Gucy1b2b; Gucy1b2; SGC", "protein_names_uniprotkb": "Guanylate cyclase soluble subunit beta-2; 4.6.1.2; GCS-beta-2", "protein_names_refseq": "GCS-beta-2; Guanylate cyclase, soluble, beta 2 (GTP pyrophosphate - lyase); guanylate cyclase 1, soluble, beta 2; guanylate cyclase soluble subunit beta-2 isoform 1; guanylate cyclase soluble subunit beta-2; soluble guanylate cyclase beta 2a; soluble guanylate cyclase beta 2b", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 1 (Disease Ontology:DOID:0080092); dilated cardiomyopathy 1I (Disease Ontology:DOID:0110431); neurogenic scapuloperoneal syndrome Kaeser type (Disease Ontology:DOID:0111551); dilated cardiomyopathy (Disease Ontology:DOID:12930); restrictive cardiomyopathy (Disease Ontology:DOID:397); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (rno:25206); (R-RNO-445355)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11770014;15652699;16331987;17098738;1980215", "class_list": "", "function": "Expression of the beta 2 subunit of soluble guanylyl cyclase is switched on at a time when the urinary concentrating capacity develops, between postnatal days 16 to 22, increasing strongly in intensity in adult animals., [RefSeq, PubMed]; For the function of sGC in vivo, where there is evidence for two nitric oxide-regulated activity states, [RefSeq, PubMed]; Results identify and characterize the minimum functional ligand-binding heme domain derived from soluble guanylate cyclase., [RefSeq, PubMed]; These data support our hypothesis and provide anatomical support for the suggestion that nitroxidergic activation of the NTS involves sGC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0070026 nitric oxide binding", "go_cellular_component": "GO:0005829 cytosol;GO:0008074 guanylate cyclase complex, soluble", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0070482 response to oxygen levels", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P22717-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54702-1", "uniprot_id": "CHSTA_RAT", "mass": 42027.0, "length": 356, "protein_name": "Carbohydrate sulfotransferase 10", "gene_name": "Chst10", "organism": "Rat", "refseq_name": "carbohydrate sulfotransferase 10", "refseq_ac": "NP_536322", "gene_names_uniprotkb": "Chst10", "gene_names_refseq": "Chst10; HNK1ST; Hnk-1st; raHNK-1ST; sul-T", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 10; 2.8.2.-; HNK-1 sulfotransferase; HNK-1ST; HNK1ST; RaHNK-1ST; Sul-T", "protein_names_refseq": "HNK-1 sulfotransferase; carbohydrate sulfotransferase 10", "tax_id": 10116, "disease": "", "pathway": " (rno:140568); (R-RNO-975578); (R-RNO-9939291)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11044619;16543228;23723439;9368071", "class_list": "glycan-modifying enzyme;glycogene", "function": "Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis (PubMed:9368071). Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, conferring binding specificity to extracellular matrix components (PubMed:23723439). Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O-(beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D-glucuronate) hormones (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; The function of glucuronyltransfease is relevant to the efficient sequential biosynthesis of the HNK-1 carbohydrate., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0016232 HNK-1 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0016051 carbohydrate biosynthetic process;GO:0007612 learning;GO:0008209 androgen metabolic process;GO:0007616 long-term memory", "synthesized_glycan_count": 16, "hit_score": 0.5, "record_id": "O54702-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07867-1", "uniprot_id": "LIPC_RAT", "mass": 55623.0, "length": 494, "protein_name": "Hepatic triacylglycerol lipase", "gene_name": "Lipc", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lipc", "gene_names_refseq": "", "protein_names_uniprotkb": "Hepatic triacylglycerol lipase; 3.1.1.32; 3.1.1.3; 3.1.1.5; HL; Hepatic lipase; Lipase member C; Lysophospholipase; Phospholipase A1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Middle East respiratory syndrome (Disease Ontology:DOID:0080642); Alzheimer's disease (Disease Ontology:DOID:10652); familial hyperlipidemia (Disease Ontology:DOID:1168); protein-energy malnutrition (Disease Ontology:DOID:11801); nephrotic syndrome (Disease Ontology:DOID:1184); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); familial combined hyperlipidemia (Disease Ontology:DOID:13809); hypothyroidism (Disease Ontology:DOID:1459); hyperinsulinism (Disease Ontology:DOID:2018); hepatitis (Disease Ontology:DOID:2237); ischemia (Disease Ontology:DOID:326); coronary artery disease (Disease Ontology:DOID:3393); peripheral vascular disease (Disease Ontology:DOID:341); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); kidney disease (Disease Ontology:DOID:557); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24538); (R-RNO-8963889); (R-RNO-8964026)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1531641;1770315;1865764;21454685;2322583;3470738;6747460;7074125", "class_list": "", "function": "Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles. Also exhibits lysophospholipase activity. Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates. In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.3;3.1.1.4;3.1.1.32;2.3.1.-;2.3.1.51;3.1.1.-;3.1.1.5;3.1.1.23;3.1.1.79;3.1.1.6;3.5.1.1;3.1.1.47;3.1.1.13;3.1.1.116;3.1.1.26;3.1.2.22;3.1.2.-;3.1.1.111;3.1.2.2;3.1.1.34;3.1.-.-", "go_molecular_function": "GO:0008201 heparin binding;GO:0016298 lipase activity;GO:0034185 apolipoprotein binding;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0009986 cell surface;GO:0034364 high-density lipoprotein particle;GO:0005770 late endosome", "go_biological_process": "GO:0046473 phosphatidic acid metabolic process;GO:0097006 regulation of plasma lipoprotein particle levels;GO:0001889 liver development;GO:0006631 fatty acid metabolic process;GO:0006641 triglyceride metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P07867-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08683-1", "uniprot_id": "CP2CB_RAT", "mass": 57181.0, "length": 500, "protein_name": "Cytochrome P450 2C11", "gene_name": "Cyp2c11", "organism": "Rat", "refseq_name": "cytochrome P450 2C11", "refseq_ac": "NP_062057", "gene_names_uniprotkb": "Cyp2c11; Cyp2c-11; Cyp2c", "gene_names_refseq": "CYP2CII; Cyp2c11l; Cyp2c11; Cyp2c", "protein_names_uniprotkb": "Cytochrome P450 2C11; 1.14.14.1; CYPIIC11; Cytochrome P-450(M-1); Cytochrome P450-UT-2; Cytochrome P450-UT-A; Cytochrome P450H", "protein_names_refseq": "CYPIIC11; P-450(M-1); P450-UT-A; P450H; UT-2; cytochrome P-450(M-1); cytochrome P450 2C11-like; cytochrome P450 2C11; cytochrome P450, 2c29; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 11; cytochrome P450-UT-2; cytochrome P450-UT-A; cytochrome P450H", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); depressive disorder (Disease Ontology:DOID:1596); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:29277); (R-RNO-211981); (R-RNO-211999); (R-RNO-2142670); (R-RNO-2142816); (R-RNO-9027307); (R-RNO-9749641)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "10491410;15766564;2434473;2455430;28419964;28555194;2894840;29444903;31271766;3164963;32707261;3805049;8068205;8611037", "class_list": "", "function": "A CYP2C11-null rat model was successfully generated and is a valuable tool to study the in vivo function of CYP2C11., [RefSeq, PubMed]; A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and fatty acids. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes testosterone to 2alpha- and 16alpha-hydroxytestosterone (PubMed:2434473). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFAs) (PubMed:10491410, PubMed:15766564). Converts arachidonic acid (ARA, C20:4(n-6)) primarily to epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, with both R,S and S,R stereochemistry (PubMed:10491410). Preferentially produces 11R,12S-EET enantiomer. To a lesser extent, catalyzes the hydroxylation of arachidonic acid producing hydroxyeicosatetraenoates (HETEs) (PubMed:10491410). Metabolizes eicosapentaenoic acid (EPA, C20:5(n-3)) to epoxyeicosatetraenoic acid (EETeTr) regioisomers, 8,9-, 11,12-, 14,15-, and 17,18-EETeTr, preferentially producing 17R,18S-EETeTr enantiomer (PubMed:15766564). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:15766564, PubMed:2434473)., [UniProtKB, PubMed, PubMed, PubMed]; Acute Formaldehyde (FA) poisoning suppressed the activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity of CYP1A2 in rats. And the change of CYP450 activity caused by acute FA poisoning may be associated with FA potential carcinogenic effects on the airways., [RefSeq, PubMed]; Inflammation in astrocytes could down-regulate CYP2C11 mRNA, protein and activity.Inhibition of NF-kappaB partially prevented the down-regulation of CYP2C11 mRNA and protein.NF-kappaB is able to bind to at least two response elements in the promoter of Cyp2c11., [RefSeq, PubMed]; Neuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain., [RefSeq, PubMed]; The PE extract also showed a significant potential to reduce CYP3A and CYP2C protein expression by approximately 50%., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63141;Q64554", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;1.14.14.80", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0008404 arachidonate 14,15-epoxygenase activity;GO:0008405 arachidonate 11,12-epoxygenase activity;GO:0005506 iron ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046456 icosanoid biosynthetic process;GO:0042573 retinoic acid metabolic process;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P08683-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49653-1", "uniprot_id": "P2RX2_RAT", "mass": 52617.0, "length": 472, "protein_name": "P2X purinoceptor 2", "gene_name": "P2rx2", "organism": "Rat", "refseq_name": "P2X purinoceptor 2", "refseq_ac": "NP_446108", "gene_names_uniprotkb": "P2rx2", "gene_names_refseq": "P2X2; P2rx2", "protein_names_uniprotkb": "P2X purinoceptor 2; ATP receptor; P2X2; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2X purinoceptor 2; purinergic receptor P2X, ligand-gated ion channel, 2", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 41 (Disease Ontology:DOID:0110567)", "pathway": " (rno:114115); (R-RNO-139853); (R-RNO-418346)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10440098;11181939;12921863;15313628;17449665;18616429;25680470;26808983;26843630;29608947;32145326;7523952;7542879;8961184;9119082", "class_list": "", "function": "A trafficking mechanism for 5-HT3A receptor depends on a functional interaction with P2X2 receptor., [RefSeq, PubMed]; ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10440098, PubMed:8961184, PubMed:9119082). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle., [UniProtKB, UniProtKB]; P2X3 and P2X2/3 receptors activation induces articular hyperalgesia by an indirect sensitization of the primary afferent nociceptor in the rats' knee joint., [RefSeq, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB, UniProtKB]; Study showed that in a rat model of neuropathic pain, Schwann cell and microencapsulated-Schwann cell transplantation reduce P2X2/3 receptor expression in L4-5 dorsal root ganlia., [RefSeq, PubMed]; The study explores the association of the phenotype of ATP-activated current with the genotype of P2X1-6 subunits in neurons innervating tooth-pulp., [RefSeq, PubMed]; These data further reveal that the inner and outer ends of adjacent pore-lining helices come closer during opening, likely through a hinge-bending motion. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O54868", "ec_number_list": "2.7.11.1;1.8.-.-", "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling;GO:0030432 peristalsis;GO:0002931 response to ischemia;GO:0007274 neuromuscular synaptic transmission;GO:0007528 neuromuscular junction development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P49653-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13635-1", "uniprot_id": "CERU_RAT", "mass": 120841.0, "length": 1059, "protein_name": "Ceruloplasmin", "gene_name": "Cp", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cp", "gene_names_refseq": "", "protein_names_uniprotkb": "Ceruloplasmin; 1.11.1.27; 1.11.1.9; 1.16.3.1; 1.16.3.4; Cuproxidase ceruloplasmin; Ferroxidase ceruloplasmin; Glutathione peroxidase ceruloplasmin; Glutathione-dependent peroxiredoxin ceruloplasmin", "protein_names_refseq": "", "tax_id": 10116, "disease": "aceruloplasminemia (Disease Ontology:DOID:0050711); heart disease (Disease Ontology:DOID:114); hemosiderosis (Disease Ontology:DOID:12119); cholestasis (Disease Ontology:DOID:13580); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); systemic scleroderma (Disease Ontology:DOID:418); brain edema (Disease Ontology:DOID:4724); hyperthyroidism (Disease Ontology:DOID:7998); Wilson disease (Disease Ontology:DOID:893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24268); (R-RNO-381426); (R-RNO-425410); (R-RNO-8957275); (R-RNO-917937)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "14707133;21454685;2332446;3818625", "class_list": "", "function": "Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q64719", "ec_number_list": "1.16.3.1;1.11.1.27;3.1.1.4;2.3.1.23;1.11.1.12;1.11.1.9;5.3.4.1;3.1.1.3;1.16.3.4;3.4.21.69;3.4.21.-;3.4.24.81;2.4.1.145;3.6.4.-;3.2.1.51;1.8.3.2;3.4.21.112", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0016491 oxidoreductase activity;GO:0005507 copper ion binding;GO:0004322 ferroxidase activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001889 liver development;GO:0006878 intracellular copper ion homeostasis;GO:0006954 inflammatory response;GO:0007584 response to nutrient;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P13635-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47971-1", "uniprot_id": "NPTX1_RAT", "mass": 47216.0, "length": 432, "protein_name": "Neuronal pentraxin-1", "gene_name": "Nptx1", "organism": "Rat", "refseq_name": "neuronal pentraxin-1 precursor", "refseq_ac": "NP_714957", "gene_names_uniprotkb": "Nptx1", "gene_names_refseq": "Nptx1", "protein_names_uniprotkb": "Neuronal pentraxin-1; 47 kDa taipoxin-binding protein; NP-I; NP1; Neuronal pentraxin I", "protein_names_refseq": "47 kDa taipoxin-binding protein; NP-I; NP1; neuronal pentraxin I; neuronal pentraxin-1 precursor", "tax_id": 10116, "disease": "autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (rno:266777)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10748068;15115814;22427704;22956834;24090084;34142698;38843836;7695898", "class_list": "", "function": "Data indicate that expression of neuronal pentraxin 1 (NP1) in insulinoma INS-1E cells in insulin-secreting cells is modulated by high glucose and that NP1 in INS-1E cells is linked to the AKT/GSK3 pathway., [RefSeq, PubMed]; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses., [UniProtKB, PubMed]; MiR-139-5p mediates the palmitate-induced inhibition of insulin secretion by targeting neuronal pentraxin 1 in INS-1 cells., [RefSeq, PubMed]; Our results show that neuronal pentraxin 1 induction mediates hypoxic-ischemic injury probably by interacting with and modulating GluR1 and potentially other excitatory glutamate receptors, [RefSeq, PubMed]; Rescue of NP1 expression in the rostral ventromedial medulla (RVM) restores behavioral hypersensitivity of knock-out mice, demonstrating a key role of NP1 in the pathogenesis of neuropathic pain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0043083 synaptic cleft;GO:0030133 transport vesicle", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0006839 mitochondrial transport;GO:0071333 cellular response to glucose stimulus;GO:0043653 mitochondrial fragmentation involved in apoptotic process;GO:0060385 axonogenesis involved in innervation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P47971-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25086-1", "uniprot_id": "IL1RA_RAT", "mass": 20282.0, "length": 178, "protein_name": "Interleukin-1 receptor antagonist protein", "gene_name": "Il1rn", "organism": "Rat", "refseq_name": "interleukin-1 receptor antagonist protein precursor", "refseq_ac": "NP_071530", "gene_names_uniprotkb": "Il1rn; Il-1ra", "gene_names_refseq": "IL-1ra; Il1ra; Il1rn", "protein_names_uniprotkb": "Interleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IL1 inhibitor; IRAP", "protein_names_refseq": "IL-1RN; IL1 inhibitor; IRAP; interleukin-1 receptor antagonist protein precursor; interleukin-1 receptor antagonist protein", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); Muckle-Wells syndrome (Disease Ontology:DOID:0050854); stroke (Disease Ontology:DOID:0051061); interleukin-1 receptor antagonist deficiency (Disease Ontology:DOID:0061225); herpes simplex virus keratitis (Disease Ontology:DOID:0080158); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); keratoconus (Disease Ontology:DOID:10126); dry eye syndrome (Disease Ontology:DOID:10140); pleurisy (Disease Ontology:DOID:10247); silicosis (Disease Ontology:DOID:10325); common cold (Disease Ontology:DOID:10459); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); pleural tuberculosis (Disease Ontology:DOID:106); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); IgA vasculitis (Disease Ontology:DOID:11123); allergic conjunctivitis (Disease Ontology:DOID:11204); corneal neovascularization (Disease Ontology:DOID:11382); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pyelonephritis (Disease Ontology:DOID:11400); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); listeriosis (Disease Ontology:DOID:11573); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); cicatricial pemphigoid (Disease Ontology:DOID:11656); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); morbid obesity (Disease Ontology:DOID:11981); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); Sjogren's syndrome (Disease Ontology:DOID:12894); crescentic glomerulonephritis (Disease Ontology:DOID:13139); Behcet's disease (Disease Ontology:DOID:13241); pulmonary sarcoidosis (Disease Ontology:DOID:13406); anterior uveitis (Disease Ontology:DOID:1407); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); pleural disease (Disease Ontology:DOID:1532); depressive disorder (Disease Ontology:DOID:1596); vascular disease (Disease Ontology:DOID:178); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); hairy cell leukemia (Disease Ontology:DOID:285); glomerulonephritis (Disease Ontology:DOID:2921); bronchiolitis (Disease Ontology:DOID:2942); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); bronchus carcinoma (Disease Ontology:DOID:3904); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); Schnitzler syndrome (Disease Ontology:DOID:4371); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); ureteral obstruction (Disease Ontology:DOID:5199); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); fibromyalgia (Disease Ontology:DOID:631); myositis (Disease Ontology:DOID:633); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); periodontitis (Disease Ontology:DOID:824); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); learning disability (Disease Ontology:DOID:8927); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary eosinophilia (Disease Ontology:DOID:9498); multiple myeloma (Disease Ontology:DOID:9538); encephalitis (Disease Ontology:DOID:9588); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); dacryocystitis (Disease Ontology:DOID:9938); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:60582); (R-RNO-9020702)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1828896;24376764;24621600;32007102", "class_list": "", "function": "Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense. Publication Status: Online-Only, [RefSeq, PubMed]; IL-1beta is the key trigger of neuroinflammation and that IL-1ra prevents the neuroinflammation entering the chronic state Publication Status: Online-Only, [RefSeq, PubMed]; Interleukin-1beta and interleukin-1 receptor antagonist appear in grey matter additionally to white matter during experimental multiple sclerosis Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 92, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005152 interleukin-1 receptor antagonist activity;GO:0005150 interleukin-1, type I receptor binding;GO:0045352 interleukin-1 type I receptor antagonist activity;GO:0045353 interleukin-1 type II receptor antagonist activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0031982 vesicle", "go_biological_process": "GO:0001660 fever generation;GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0006629 lipid metabolic process;GO:0006954 inflammatory response;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P25086-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14137-1", "uniprot_id": "CP11A_RAT", "mass": 60586.0, "length": 526, "protein_name": "Cholesterol side-chain cleavage enzyme, mitochondrial", "gene_name": "Cyp11a1", "organism": "Rat", "refseq_name": "cholesterol side-chain cleavage enzyme, mitochondrial precursor", "refseq_ac": "NP_058982", "gene_names_uniprotkb": "Cyp11a1; Cyp11a-1; Cyp11a", "gene_names_refseq": "Cyp11a1; Cyp11a; Cypxia1; P450(scc); P450scc", "protein_names_uniprotkb": "Cholesterol side-chain cleavage enzyme, mitochondrial; 1.14.15.6; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)", "protein_names_refseq": "cholesterol desmolase; cholesterol side-chain cleavage cytochrome P450; cholesterol side-chain cleavage enzyme, mitochondrial precursor; cholesterol side-chain cleavage enzyme, mitochondrial; cytochrome P450 11A1; cytochrome P450 11a cholesterol side chain cleavage; cytochrome P450 family 11 subfamily a; cytochrome P450 side-chain cleavage enzyme; cytochrome P450 subfamily 11A; cytochrome P450(scc)", "tax_id": 10116, "disease": "congenital adrenal insufficiency (Disease Ontology:DOID:0050546); congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); status epilepticus (Disease Ontology:DOID:1824); hypogonadism (Disease Ontology:DOID:1924); nephrosis (Disease Ontology:DOID:2527); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29680); (R-RNO-196108); (R-RNO-211976)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "21075169;2170421;2176216;2480959;30884106;3123325;34038751;34215832;39094930;3948785", "class_list": "", "function": "A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR transcripts in C2C12 myoblasts., [RefSeq, PubMed]; Flutamide treatment reveals a relationship between steroidogenic activity of Leydig cells and ultrastructure of their mitochondria. Publication Status: Online-Only, [RefSeq, PubMed]; Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations., [RefSeq, PubMed]; These steroidogenic enzymes within the Leydig cells, including steroidogenic acute regulatory protein (StAR), cholesterol side-chain cleavage cytochrome P450 (P450scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD), were down-regulated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWY8;Q6LDR9", "ec_number_list": "1.14.15.6;1.18.1.6", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043204 perikaryon;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0043279 response to alkaloid;GO:0007584 response to nutrient;GO:0007617 mating behavior;GO:0008203 cholesterol metabolic process;GO:0010332 response to gamma radiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P14137-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01621-1", "uniprot_id": "LCK_RAT", "mass": 57890.0, "length": 509, "protein_name": "Proto-oncogene tyrosine-protein kinase LCK", "gene_name": "Lck", "organism": "Rat", "refseq_name": "proto-oncogene tyrosine-protein kinase LCK", "refseq_ac": "NP_001094179", "gene_names_uniprotkb": "Lck", "gene_names_refseq": "Lck1; Lcktkr; Lck; p56-LCK", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase LCK; 2.7.10.2; Lymphocyte cell-specific protein-tyrosine kinase; p56-LCK", "protein_names_refseq": "lymphocyte cell-specific protein-tyrosine kinase; lymphocyte protein tyrosine kinase; lymphocyte-specific protein tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK", "tax_id": 10116, "disease": "immunodeficiency 22 (Disease Ontology:DOID:0111937); intestinal cancer (Disease Ontology:DOID:10155); allergic conjunctivitis (Disease Ontology:DOID:11204); cancer (Disease Ontology:DOID:162); Goldenhar syndrome (Disease Ontology:DOID:2907); carcinoma (Disease Ontology:DOID:305); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); kidney disease (Disease Ontology:DOID:557); retinal degeneration (Disease Ontology:DOID:8466); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:313050); (R-RNO-114604); (R-RNO-1257604); (R-RNO-1433557); (R-RNO-1433559); (R-RNO-202424); (R-RNO-202427); (R-RNO-202430); (R-RNO-202433); (R-RNO-210990); (R-RNO-2424491); (R-RNO-389356); (R-RNO-389357); (R-RNO-389359); (R-RNO-389513); (R-RNO-389948); (R-RNO-6811558); (R-RNO-9013407); (R-RNO-9020558)", "pathway_count": 19, "publication_count": 5, "publication_id_list": "1594248;22673903;31788330;38263783;8423992", "class_list": "", "function": "Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR-CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR-CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP (By similarity). Interacts with UNC119; this interaction plays a crucial role in activation of LCK (By similarity)., [UniProtKB]; RNA-Sequencing Analysis and Expression of Lymphocyte-Specific Protein Tyrosine Kinase, Linker for Activation of T Cells, and 70-kDa T-Cell Receptor Zeta-Chain Associated Protein Kinase in Rat Liver Transplant Rejection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1H265", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.11.1;2.7.1.153;2.7.1.137;2.7.10.2;2.7.1.154;2.3.2.27;2.7.12.2;2.7.1.40;3.1.3.48;2.3.1.-;3.6.5.2;2.7.11.13;3.1.4.11;2.7.10.4;3.6.4.6;3.1.3.16;2.7.11.22;2.7.1.32;2.7.1.82;3.2.2.6;2.7.11.39;2.7.11.23;3.6.5.-;2.1.1.13;3.2.1.31", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0038094 Fc-gamma receptor signaling pathway;GO:0006468 protein phosphorylation;GO:0007166 cell surface receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010043 response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q01621-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C0L6-1", "uniprot_id": "NPSR1_RAT", "mass": 42638.0, "length": 372, "protein_name": "Neuropeptide S receptor", "gene_name": "Npsr1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Npsr1; Gpr154", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuropeptide S receptor; G protein-coupled receptor 154", "protein_names_refseq": "", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); childhood-onset asthma (Disease Ontology:DOID:0080815); nocturnal asthma (Disease Ontology:DOID:0080826); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); sleep disorder (Disease Ontology:DOID:535); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:300458); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G protein-coupled receptor for neuropeptide S (NPS). Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade. Inhibits cell growth in response to NPS binding., [UniProtKB, UniProtKB]; G-protein coupled receptor for neuropeptide S (NPS). Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade. Inhibits cell growth in response to NPS binding., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:2000293 negative regulation of defecation;GO:0007218 neuropeptide signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0042755 eating behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C0L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08154-1", "uniprot_id": "EGR1_RAT", "mass": 53935.0, "length": 508, "protein_name": "Early growth response protein 1", "gene_name": "Egr1", "organism": "Rat", "refseq_name": "early growth response protein 1", "refseq_ac": "NP_036683", "gene_names_uniprotkb": "Egr1", "gene_names_refseq": "Egr1; Krox-24; NGFI-A; Ngf1; Ngfi; zif-268", "protein_names_uniprotkb": "Early growth response protein 1; EGR-1; NGFI-A; Nerve growth factor-induced protein A; Transcription factor Zif268; Zinc finger protein Krox-24", "protein_names_refseq": "early growth response protein 1; nerve growth factor-induced protein A; transcription factor Zif268; zinc finger protein Krox-24", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); myelodysplastic syndrome (Disease Ontology:DOID:0050908); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); pulmonary sarcoidosis (Disease Ontology:DOID:13406); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); squamous cell carcinoma (Disease Ontology:DOID:1749); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); osteosarcoma (Disease Ontology:DOID:3347); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); lung disease (Disease Ontology:DOID:850); pulmonary emphysema (Disease Ontology:DOID:9675); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:24330)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15220929;1859855;2492104;36527644;3672127;36759943;38324049;38650141;38943627;8413279", "class_list": "", "function": "ATF3/EGR1 regulates myocardial ischemia/reperfusion injury induced autophagy and inflammation in cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and in Experimental Tumours In Vivo., [RefSeq, PubMed]; Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration., [RefSeq, PubMed]; PTZ-kindled rat model; evaluation of seizure, hippocampal EGR-1, and Rev-erbalpha gene regulation, behavioral analysis, and antioxidant capacity of Gum Arabic. Publication Status: Online-Only, [RefSeq, PubMed]; The involvement of EGR1 in neuron apoptosis in the in vitro model of spinal cord injury via BTG2 up-regulation., [RefSeq, PubMed]; Transcriptional regulator (PubMed:8413279). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:15220929). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). Regulates biosynthesis of glucocorticoid receptor GR/NR3C1 in the hippocampus and thereby may play a role in the behavioral and hypothalamic-pituitary-adrenal responses to stress in offspring (PubMed:15220929)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53YM5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0034465 response to carbon monoxide;GO:0070498 interleukin-1-mediated signaling pathway;GO:0060086 circadian temperature homeostasis;GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0071317 cellular response to isoquinoline alkaloid", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08154-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZHA0-1", "uniprot_id": "FLNC_RAT", "mass": 290986.0, "length": 2726, "protein_name": "Filamin-C", "gene_name": "Flnc", "organism": "Rat", "refseq_name": "filamin-C", "refseq_ac": "NP_001178791", "gene_names_uniprotkb": "Flnc; Abpl; Fln2", "gene_names_refseq": "ABP-L; FLN-C; Flnc", "protein_names_uniprotkb": "Filamin-C; ABP-280-like protein; ABP-L; Actin-binding-like protein; FLN-C; Filamin-2; Gamma-filamin", "protein_names_refseq": "ABP-280-like protein; actin-binding-like protein; filamin C, gamma (actin binding protein 280); filamin-2; filamin-C; gamma-filamin", "tax_id": 10116, "disease": "myofibrillar myopathy 5 (Disease Ontology:DOID:0080096); hypertrophic cardiomyopathy 26 (Disease Ontology:DOID:0110327); distal myopathy 4 (Disease Ontology:DOID:0111190); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (rno:362332); (R-RNO-446353)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15886195;21223964;22673903", "class_list": "", "function": "Muscle-specific filamin, which plays a central role in sarcomere assembly and organization. Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events., [UniProtKB, UniProtKB]; Physical interaction between RasGAP and FLN-C facilitates an interaction between G3BP and cdk7 mRNA, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0008092 cytoskeletal protein binding;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0042383 sarcolemma;GO:0030018 Z disc", "go_biological_process": "GO:0045214 sarcomere organization;GO:0055001 muscle cell development;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZHA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56163-1", "uniprot_id": "DPF1_RAT", "mass": 45193.0, "length": 397, "protein_name": "Zinc finger protein neuro-d4", "gene_name": "Dpf1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dpf1; Baf45b; Neud4", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein neuro-d4; BAF45B; BRG1-associated factor 45B; D4, zinc and double PHD fingers family 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:50545); (R-RNO-9933937)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "1454523", "class_list": "", "function": "May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0071565 nBAF complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56163-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13386-1", "uniprot_id": "FCERB_RAT", "mass": 26731.0, "length": 243, "protein_name": "High affinity immunoglobulin epsilon receptor subunit beta", "gene_name": "Ms4a2", "organism": "Rat", "refseq_name": "high affinity immunoglobulin epsilon receptor subunit beta", "refseq_ac": "NP_036977", "gene_names_uniprotkb": "Ms4a2; Fce1b; Fcer1b", "gene_names_refseq": "FCIGA; Fcer1b; Ms4a1; Ms4a2", "protein_names_uniprotkb": "High affinity immunoglobulin epsilon receptor subunit beta; Fc epsilon receptor I beta-chain; FcERI; IgE Fc receptor subunit beta; Membrane-spanning 4-domains subfamily A member 2", "protein_names_refseq": "IgE Fc receptor subunit beta; Membrane-spanning 4-domains, subfamily A, member 1; beta polypeptide); fc epsilon receptor I beta-chain; fcERI; high affinity immunoglobulin epsilon receptor subunit beta; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for", "tax_id": 10116, "disease": "asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (rno:25316); (R-RNO-2454202); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-2871837)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "18579528;21746961;23443658;2970642", "class_list": "", "function": "Chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family, [RefSeq, PubMed]; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy., [UniProtKB]; Membrane-spanning 4-domains, subfamily A, member 2 pathway?, [RefSeq, PubMed]; PLSCR1 is a novel amplifier of FcepsilonRI signaling that acts selectively on the Lyn-initiated LAT/phospholipase Cgamma1/calcium axis, resulting in potentiation of a selected set of mast cell responses, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019863 IgE binding;GO:0019901 protein kinase binding;GO:0051219 phosphoprotein binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0032998 Fc-epsilon receptor I complex;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0043306 positive regulation of mast cell degranulation;GO:0051279 regulation of release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P13386-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ABY2-1", "uniprot_id": "COPG2_RAT", "mass": 80489.0, "length": 715, "protein_name": "Coatomer subunit gamma-2", "gene_name": "Copg2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Copg2", "gene_names_refseq": "", "protein_names_uniprotkb": "Coatomer subunit gamma-2; Gamma-2-COP; Gamma-2-coat protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:301742); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "17360540", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0030426 growth cone;GO:0030137 COPI-coated vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009306 protein secretion;GO:0072384 organelle transport along microtubule;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4ABY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22062-1", "uniprot_id": "PIMT_RAT", "mass": 24641.0, "length": 227, "protein_name": "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "gene_name": "Pcmt1", "organism": "Rat", "refseq_name": "protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform b", "refseq_ac": "NP_037205", "gene_names_uniprotkb": "Pcmt1", "gene_names_refseq": "PCM; Pcmt1", "protein_names_uniprotkb": "Protein-L-isoaspartate(D-aspartate) O-methyltransferase; 2.1.1.77; L-isoaspartyl protein carboxyl methyltransferase; PIMT; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase", "protein_names_refseq": "L-isoaspartyl protein carboxyl methyltransferase; PIMT; protein L-isoaspartyl/D-aspartyl methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform b; protein-L-isoaspartate(D-aspartate) O-methyltransferase; protein-beta-aspartate methyltransferase", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (rno:25604); (R-RNO-5676934)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "24358311;26973341;2730663;8263531", "class_list": "", "function": "ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (By similarity). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PIMT was critical for bFGF-mediated neuronal differentiation of PC12 cells and regulated the MAPK and Akt signaling pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M7V6", "ec_number_list": "2.1.1.77", "go_molecular_function": "GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016323 basolateral plasma membrane;GO:0043204 perikaryon", "go_biological_process": "GO:0045471 response to ethanol;GO:0071456 cellular response to hypoxia;GO:0006479 protein methylation;GO:0010667 negative regulation of cardiac muscle cell apoptotic process;GO:0046498 S-adenosylhomocysteine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P22062-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10867-1", "uniprot_id": "GGLO_RAT", "mass": 50615.0, "length": 440, "protein_name": "L-gulonolactone oxidase", "gene_name": "Gulo", "organism": "Rat", "refseq_name": "L-gulonolactone oxidase", "refseq_ac": "NP_071556", "gene_names_uniprotkb": "Gulo", "gene_names_refseq": "Gulo", "protein_names_uniprotkb": "L-gulonolactone oxidase; 1.1.3.8; GLO; L-gulono-gamma-lactone oxidase; LGO", "protein_names_refseq": "GLO; L-gulono-gamma-lactone oxidase; L-gulonolactone oxidase; LGO", "tax_id": 10116, "disease": "", "pathway": " (rno:60671)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1400507;1962571;3214183;3338984;8459881", "class_list": "", "function": "Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBC1;Q64597;Q9QWR6", "ec_number_list": "1.1.3.8", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity;GO:0003885 D-arabinono-1,4-lactone oxidase activity;GO:0050105 L-gulonolactone oxidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019853 L-ascorbic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P10867-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20814-1", "uniprot_id": "CP2CD_RAT", "mass": 55860.0, "length": 490, "protein_name": "Cytochrome P450 2C13, male-specific", "gene_name": "Cyp2c13", "organism": "Rat", "refseq_name": "cytochrome P450 2C13, male-specific", "refseq_ac": "NP_612523", "gene_names_uniprotkb": "Cyp2c13; Cyp2c-13", "gene_names_refseq": "Cyp2c13; Cyp2c38", "protein_names_uniprotkb": "Cytochrome P450 2C13, male-specific; 1.14.14.1; CYPIIC13; Cytochrome P-450g; Cytochrome P450-G; Cytochrome P450-UT-5", "protein_names_refseq": "CYP2C13 (+); CYPIIC13; P-450g; P450-G; UT-5; cytochrome P-450g; cytochrome P450 2C13, male-specific-like; cytochrome P450 2C13, male-specific; cytochrome P450 g (+); cytochrome P450, 2c38; cytochrome P450-G; cytochrome P450-UT-5", "tax_id": 10116, "disease": "renal hypertension (Disease Ontology:DOID:1073); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:171521)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "2325668;2337591;2434473;2775738", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P22693;Q64587", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20814-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04218-1", "uniprot_id": "OX2G_RAT", "mass": 31088.0, "length": 278, "protein_name": "OX-2 membrane glycoprotein", "gene_name": "Cd200", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cd200; Mox2", "gene_names_refseq": "", "protein_names_uniprotkb": "OX-2 membrane glycoprotein; MRC OX-2 antigen", "protein_names_refseq": "", "tax_id": 10116, "disease": "autoimmune disease (Disease Ontology:DOID:417)", "pathway": " (R-RNO-198933)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2862025;38843836", "class_list": "", "function": "Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity;GO:0086080 protein binding involved in heterotypic cell-cell adhesion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:1904465 negative regulation of matrix metallopeptidase secretion;GO:1905522 negative regulation of macrophage migration;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P04218-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02401-1", "uniprot_id": "LPH_RAT", "mass": 217268.0, "length": 1928, "protein_name": "Lactase/phlorizin hydrolase", "gene_name": "Lct", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lct; Lph", "gene_names_refseq": "", "protein_names_uniprotkb": "Lactase/phlorizin hydrolase; Lactase/glycosylceramidase; Phlorizin hydrolase", "protein_names_refseq": "", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); congenital lactase deficiency (Disease Ontology:DOID:0111646); diarrhea (Disease Ontology:DOID:13250); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:116569); (R-RNO-189085)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1339333;1691182;1909681;4752949", "class_list": "glycogene;glycosylhydrolase", "function": "Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose (PubMed:4752949). The mature protein is composed of two domains that catalyze the hydrolysis of beta-glucopyranosides and beta-galactopyranosides, with a preference for hydrophilic aglycones (in lactose and cellobiose) for one domain and hydrophobic aglycones (in phlorizin and glycosylceramides) for the other (PubMed:4752949)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 15, "predicted_n_glycosites": 15, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q63712;Q63719", "ec_number_list": "3.2.1.108;3.2.1.62", "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0008422 beta-glucosidase activity;GO:0042803 protein homodimerization activity;GO:0016740 transferase activity;GO:0004336 galactosylceramidase activity", "go_cellular_component": "GO:0005903 brush border;GO:0098591 external side of apical plasma membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0010288 response to lead ion;GO:0042594 response to starvation;GO:0045471 response to ethanol;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q02401-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZCM9-1", "uniprot_id": "DAAF3_RAT", "mass": 64373.0, "length": 583, "protein_name": "Dynein axonemal assembly factor 3", "gene_name": "Dnaaf3", "organism": "Rat", "refseq_name": "dynein axonemal assembly factor 3", "refseq_ac": "NP_001258044", "gene_names_uniprotkb": "Dnaaf3", "gene_names_refseq": "Dnaaf3", "protein_names_uniprotkb": "Dynein axonemal assembly factor 3", "protein_names_refseq": "Dynein assembly factor 3, axonemal; dynein axonemal assembly factor 3", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia 2 (Disease Ontology:DOID:0110626)", "pathway": " (rno:100359753)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007507 heart development;GO:0030324 lung development;GO:0000902 cell morphogenesis;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZCM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZKX9-1", "uniprot_id": "LOXE3_RAT", "mass": 80440.0, "length": 711, "protein_name": "Hydroperoxide isomerase ALOXE3", "gene_name": "Aloxe3", "organism": "Rat", "refseq_name": "hydroperoxide isomerase ALOXE3", "refseq_ac": "NP_001099263", "gene_names_uniprotkb": "Aloxe3", "gene_names_refseq": "Aloxe3; e-LOX-3; eLOX-3", "protein_names_uniprotkb": "Hydroperoxide isomerase ALOXE3; 4.2.1.152; 5.4.4.7; Epidermal LOX-3; Epidermis-type lipoxygenase 3; Hydroperoxy dehydratase ALOXE3; Hydroperoxy icosatetraenoate dehydratase; Hydroperoxy icosatetraenoate isomerase; e-LOX-3; eLOX-3", "protein_names_refseq": "arachidonate lipoxygenase 3; epidermal LOX-3; epidermis-type lipoxygenase 3; hydroperoxide isomerase ALOXE3; hydroperoxy dehydratase ALOXE3; hydroperoxy icosatetraenoate dehydratase; hydroperoxy icosatetraenoate isomerase", "tax_id": 10116, "disease": "autosomal recessive congenital ichthyosis 1 (Disease Ontology:DOID:0060656); autosomal recessive congenital ichthyosis 3 (Disease Ontology:DOID:0060711)", "pathway": " (rno:287424); (R-RNO-2142712)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23382512", "class_list": "", "function": "Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (By similarity). Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (PubMed:23382512)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.152;5.4.4.7;1.14.14.1;5.3.99.5;5.3.99.4", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0106255 hydroperoxy icosatetraenoate isomerase activity;GO:0106256 hydroperoxy icosatetraenoate dehydratase activity;GO:0050486 intramolecular hydroxytransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0034440 lipid oxidation;GO:0046513 ceramide biosynthetic process;GO:0061436 establishment of skin barrier;GO:0006665 sphingolipid metabolic process;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZKX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97691-1", "uniprot_id": "FOXM1_RAT", "mass": 83672.0, "length": 759, "protein_name": "Forkhead box protein M1", "gene_name": "Foxm1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Foxm1; Win", "gene_names_refseq": "", "protein_names_uniprotkb": "Forkhead box protein M1; INS-1 winged helix; Winged-helix factor from INS-1 cells", "protein_names_refseq": "", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:58921); (R-RNO-156711); (R-RNO-69273)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9242644", "class_list": "", "function": "Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001570 vasculogenesis;GO:0001889 liver development;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97691-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46892-1", "uniprot_id": "CD11B_RAT", "mass": 49547.0, "length": 436, "protein_name": "Cyclin-dependent kinase 11B", "gene_name": "Cdk11b", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cdk11b; Cdc2l1; Cdk11", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-dependent kinase 11B; 2.7.11.22; 2.7.11.23; Cell division cycle 2-like protein kinase 1; Cell division protein kinase 11; Cyclin-dependent kinase 11; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:252879); (R-RNO-380270)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;8049264", "class_list": "", "function": "Cyclin-dependent protein kinase that acts as a regulator of transcription and pre-mRNA splicing (By similarity). Acts as a key regulator of pre-mRNA splicing by mediating phosphorylation of SF3B1, enabling the association between SF3B1 and U5 and U6 snRNAs in the activated spliceosome, thereby promoting spliceosome assembly (By similarity). Also acts as a regulator of transcription by phosphorylating 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity). Involved in replication-dependent transcription of histone genes: binds to histone genes and phosphorylates POLR2A at 'Ser-2' of the CTD to specifically control transcriptional elongation of histones and recruitment of 3'-end processing factors (By similarity). Part of a transcription checkpoint upstream of CDK9, which regulates promoter-proximal pausing by RNA polymerase II, a transcription halt following transcription initiation, but prior to elongation (By similarity). Probably regulates promoter-proximal pausing by mediating phosphorylation of POLR2A at 'Ser-2' of the CTD (By similarity). Promotes centromeric transcription to maintain centromeric cohesion during mitosis (By similarity). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;3.6.5.-;3.6.4.10;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity;GO:0140834 RNA polymerase II CTD heptapeptide repeat S2 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0000775 chromosome, centromeric region;GO:0005694 chromosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0006468 protein phosphorylation;GO:0001558 regulation of cell growth;GO:0008380 RNA splicing;GO:0007088 regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P46892-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZS74-1", "uniprot_id": "OMA1_RAT", "mass": 57145.0, "length": 504, "protein_name": "Metalloendopeptidase OMA1, mitochondrial", "gene_name": "Oma1", "organism": "Rat", "refseq_name": "metalloendopeptidase OMA1, mitochondrial", "refseq_ac": "NP_001100139", "gene_names_uniprotkb": "Oma1", "gene_names_refseq": "Oma1; RGD1304821", "protein_names_uniprotkb": "Metalloendopeptidase OMA1, mitochondrial; 3.4.24.-; Overlapping with the m-AAA protease 1 homolog", "protein_names_refseq": "OMA1 homolog, zinc metallopeptidase; metalloendopeptidase OMA1, mitochondrial; overlapping with the m-AAA protease 1 homolog; zinc metallopeptidase homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:298282); (R-RNO-169911); (R-RNO-9840373)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "29393594;30926535;33383158", "class_list": "", "function": "Metalloprotease that is part of the quality control system in the inner membrane of mitochondria (PubMed:30926535). Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1 (PubMed:30926535). Involved in the fusion of the mitochondrial inner membranes by mediating cleavage of OPA1 at S1 position, generating the soluble OPA1 (S-OPA1), which cooperates with the membrane form (L-OPA1) to coordinate the fusion of mitochondrial inner membranes (By similarity). Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1, leading to excess production of soluble OPA1 (S-OPA1) and negative regulation of mitochondrial fusion (By similarity). Involved in mitochondrial safeguard in response to transient mitochondrial membrane depolarization (flickering) by catalyzing cleavage of OPA1, leading to excess production of S-OPA1, preventing mitochondrial hyperfusion (By similarity). Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae (By similarity). In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome (By similarity). May also cleave UQCC3 in response to mitochondrial depolarization (By similarity). Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (By similarity). Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity). Binds cardiolipin, possibly regulating its protein turnover (By similarity). Required for the stability of the respiratory supercomplexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Mitochondrial OPA1 cleavage is reversibly activated by differentiation of H9c2 cardiomyoblasts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.-;3.6.5.5;3.6.-.-", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033108 mitochondrial respiratory chain complex assembly;GO:0006629 lipid metabolic process;GO:0043065 positive regulation of apoptotic process;GO:0097009 energy homeostasis;GO:0006006 glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZS74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZVM4-1", "uniprot_id": "LIN41_RAT", "mass": 92125.0, "length": 855, "protein_name": "E3 ubiquitin-protein ligase TRIM71", "gene_name": "Trim71", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM71", "refseq_ac": "NP_001178730", "gene_names_uniprotkb": "Trim71; Lin41", "gene_names_refseq": "RGD1566388; Trim71", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM71; 2.3.2.27; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; Tripartite motif-containing protein 71", "protein_names_refseq": "B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41); Drosophila dappled/ vertebrate TRipartite Motif protein related; E3 ubiquitin-protein ligase TRIM71; RING-type E3 ubiquitin transferase TRIM71; protein lin-41 homolog; tripartite motif containing 71, E3 ubiquitin protein ligase; tripartite motif-containing protein 71", "tax_id": 10116, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:301042); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (By similarity). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (By similarity). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.32;2.3.2.31;2.3.2.23;2.3.2.27;2.3.2.34;2.3.2.24;2.3.2.-;2.3.2.25", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0030371 translation repressor activity;GO:0035198 miRNA binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000932 P-body", "go_biological_process": "GO:0060964 regulation of miRNA-mediated gene silencing;GO:0010608 post-transcriptional regulation of gene expression;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0001843 neural tube closure;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZWK4-1", "uniprot_id": "LMBL1_RAT", "mass": 91761.0, "length": 826, "protein_name": "Lethal(3)malignant brain tumor-like protein 1", "gene_name": "L3mbtl1", "organism": "Rat", "refseq_name": "lethal(3)malignant brain tumor-like protein 1", "refseq_ac": "NP_001406545", "gene_names_uniprotkb": "L3mbtl1; L3mbtl; L3mbt", "gene_names_refseq": "L3mbtl1; L3mbtl; RGD1307316", "protein_names_uniprotkb": "Lethal(3)malignant brain tumor-like protein 1; H-l(3)mbt protein; H-l(3)mbt; L(3)mbt protein homolog; L(3)mbt-like", "protein_names_refseq": "H-l(3)mbt protein; L(3)mbt protein homolog; L3MBTL1, histone methyl-lysine binding protein; lethal(3)malignant brain tumor-like protein 1", "tax_id": 10116, "disease": "brain cancer (Disease Ontology:DOID:1319); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (rno:311613); (R-RNO-6804760)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D4A6H6", "ec_number_list": "", "go_molecular_function": "GO:0032093 SAM domain binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000793 condensed chromosome;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030097 hemopoiesis;GO:0006325 chromatin organization;GO:0045652 regulation of megakaryocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZWK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54318-1", "uniprot_id": "LIPR2_RAT", "mass": 52535.0, "length": 468, "protein_name": "Pancreatic lipase-related protein 2", "gene_name": "Pnliprp2", "organism": "Rat", "refseq_name": "pancreatic lipase-related protein 2 precursor", "refseq_ac": "NP_476554", "gene_names_uniprotkb": "Pnliprp2; Plrp2", "gene_names_refseq": "Pnliprp2", "protein_names_uniprotkb": "Pancreatic lipase-related protein 2; 3.1.1.26; 3.1.1.3; Cytotoxic T lymphocyte lipase; Galactolipase; PL-RP2; Secretory glycoprotein GP-3; Triacylglycerol lipase", "protein_names_refseq": "PL-RP2; cytotoxic T lymphocyte lipase; galactolipase; pancreatic lipase-related protein 2 precursor; secretory glycoprotein GP-3; triacylglycerol lipase", "tax_id": 10116, "disease": "", "pathway": " (rno:117554); (R-RNO-192456)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "32963038;8203536;8486693;8656075;9822688", "class_list": "", "function": "Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:8656075, PubMed:9822688). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (By similarity). Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:8656075). Can completely deacylate triacylglycerols (By similarity). When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase (By similarity). Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (By similarity). Hydrolyzes medium- and long-chain fatty acyls in galactolipids (PubMed:9822688). May act together with LIPF to hydrolyze partially digested triglycerides (By similarity). Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity (PubMed:8656075, PubMed:9822688). In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (PubMed:32963038). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (PubMed:32963038)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.3;3.1.1.116;2.3.1.51;3.1.1.4;3.1.1.23;3.1.1.79;3.1.1.6;3.1.1.5;3.1.1.32;3.1.1.13;3.1.1.-;3.1.1.26;3.1.1.34;3.1.1.111;3.1.-.-", "go_molecular_function": "GO:0016298 lipase activity;GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity;GO:0005509 calcium ion binding;GO:0008970 phospholipase A1 activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043005 neuron projection;GO:0042589 zymogen granule membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0044258 intestinal lipid catabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0006633 fatty acid biosynthetic process;GO:0006968 cellular defense response;GO:0009395 phospholipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P54318-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35569-1", "uniprot_id": "NRG2_RAT", "mass": 93777.0, "length": 868, "protein_name": "Pro-neuregulin-2, membrane-bound isoform", "gene_name": "Nrg2", "organism": "Rat", "refseq_name": "pro-neuregulin-2, membrane-bound isoform", "refseq_ac": "NP_001129623", "gene_names_uniprotkb": "Nrg2; Ntak", "gene_names_refseq": "NTAK alpha1; NTAK alpha2a; NTAK_alpha2a; Nrg2; Ntak", "protein_names_uniprotkb": "Pro-neuregulin-2, membrane-bound isoform; NTAK; Neural- and thymus-derived activator for ERBB kinases; Pro-NRG2", "protein_names_refseq": "neural- and thymus-derived activator for ErbB kinases; pro-NRG2; pro-neuregulin-2, membrane-bound isoform", "tax_id": 10116, "disease": "", "pathway": " (rno:432361); (R-RNO-1227986); (R-RNO-1236394); (R-RNO-1250196); (R-RNO-1250342); (R-RNO-1250347); (R-RNO-1257604); (R-RNO-1306955); (R-RNO-1358803); (R-RNO-1963640); (R-RNO-1963642); (R-RNO-5673001); (R-RNO-6785631); (R-RNO-6811558); (R-RNO-8847993); (R-RNO-8863795)", "pathway_count": 16, "publication_count": 7, "publication_id_list": "15048684;26027736;26674872;27113200;31240601;9168114;9348101", "class_list": "", "function": "Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Findings reveal an intimate reciprocal relationship between ErbB4 and GluN2b NMDA receptors via NRG2/ErbB4 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; In neuronal primary cultures from developing rat hippocampus, neuregulin 2 (NRG-2) is restricted to neuronal somas and dendrites., [RefSeq, PubMed]; NRG2 and Kv2.1 are co-regulated components of a shared pathway that responds to elevated extracellular glutamate levels. Erratum:[Mol Neurobiol. 2020 Jan;57(1):585. doi: 10.1007/s12035-019-01778-4. PMID: 31522381], [RefSeq, PubMed]; NTAK/NRG2 secreted from astrocytes bound to ErbB3 on neurons, and promoted neuronal survival and neurite extension in vitro., [RefSeq, PubMed]; These results imply that NRG2 may play a critical role in network integration of newborn neurons, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O35073;O35570;O35571;O35572", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity;GO:0043125 ErbB-3 class receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007399 nervous system development;GO:0035556 intracellular signal transduction;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35569-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36198-1", "uniprot_id": "LHX2_RAT", "mass": 47419.0, "length": 426, "protein_name": "LIM/homeobox protein Lhx2", "gene_name": "Lhx2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lhx2; Lh2", "gene_names_refseq": "", "protein_names_uniprotkb": "LIM/homeobox protein Lhx2; Homeobox protein LH-2; LIM homeobox protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7678338", "class_list": "", "function": "Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P36198-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A4K3-1", "uniprot_id": "BAKOR_RAT", "mass": 55345.0, "length": 492, "protein_name": "Beclin 1-associated autophagy-related key regulator", "gene_name": "Atg14", "organism": "Rat", "refseq_name": "beclin 1-associated autophagy-related key regulator", "refseq_ac": "NP_001100728", "gene_names_uniprotkb": "Atg14; Atg14L", "gene_names_refseq": "Atg14L; Atg14; RGD1304610", "protein_names_uniprotkb": "Beclin 1-associated autophagy-related key regulator; Atg14L; Autophagy-related protein 14-like protein; Barkor", "protein_names_refseq": "ATG14 autophagy related 14 homolog; autophagy-related protein 14-like protein; barkor; beclin 1-associated autophagy-related key regulator-like; beclin 1-associated autophagy-related key regulator", "tax_id": 10116, "disease": "", "pathway": " (rno:305831); (R-RNO-1632852)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "35883156", "class_list": "", "function": "MiR-152-5p suppresses osteogenic differentiation of mandible mesenchymal stem cells by regulating ATG14-mediated autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion. Modulates the hepatic lipid metabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051020 GTPase binding;GO:0043495 protein-membrane adaptor activity;GO:0035014 phosphatidylinositol 3-kinase regulator activity;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0045335 phagocytic vesicle;GO:0005776 autophagosome;GO:0005930 axoneme", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0000045 autophagosome assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A4K3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05961-1", "uniprot_id": "OAS1A_RAT", "mass": 41666.0, "length": 358, "protein_name": "2'-5'-oligoadenylate synthase 1A", "gene_name": "Oas1a; Oas1i", "organism": "Rat", "refseq_name": "2'-5'-oligoadenylate synthase 1A isoform 2", "refseq_ac": "NP_620268", "gene_names_uniprotkb": "Oas1a; Oas1i; Oas1a; Oas1", "gene_names_refseq": "Oas1a; Oas1g; Oas1", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthase 1A; (2-5')oligo(A) synthase 1A; 2-5A synthase 1A; 2.7.7.84", "protein_names_refseq": "(2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthase 1; (2-5')oligo(A) synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1G; 2'-5'-oligoadenylate synthase 1A isoform 2; 2'-5'-oligoadenylate synthase 1A; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthetase 1; 2-5A synthase 1A; 2-5A synthase 1; 2-5A synthetase 1; 25 oligoadenylate synthetase", "tax_id": 10116, "disease": "immunodeficiency 100 (Disease Ontology:DOID:0061070)", "pathway": " (rno:192281); (rno:304507)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17024523;7764002", "class_list": "", "function": "Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Involved in intercellular immune signaling that limits local spread of RNA virus infection and protects against tumorigenesis. Can generate high levels of 2',5'-oligoadenylates in transformed cells, targeting them to innate and adaptive immunesurveillance mechanisms., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.84", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0070106 interleukin-27-mediated signaling pathway;GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0035457 cellular response to interferon-alpha;GO:0043129 surfactant homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q05961-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A7E1-1", "uniprot_id": "BATF_RAT", "mass": 14065.0, "length": 125, "protein_name": "Basic leucine zipper transcriptional factor ATF-like", "gene_name": "Batf", "organism": "Rat", "refseq_name": "basic leucine zipper transcriptional factor ATF-like", "refseq_ac": "NP_001100218", "gene_names_uniprotkb": "Batf", "gene_names_refseq": "B-ATF; Batf", "protein_names_uniprotkb": "Basic leucine zipper transcriptional factor ATF-like; B-ATF; B-cell-activating transcription factor", "protein_names_refseq": "B-cell-activating transcription factor; basic leucine zipper transcription factor, ATF-like; basic leucine zipper transcriptional factor ATF-like", "tax_id": 10116, "disease": "", "pathway": " (rno:299206)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27073891;30498928", "class_list": "", "function": "AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity)., [UniProtKB]; Hepatitis B virus markedly upregulated hepatic BATF expression and promoted Th17 cell activation., [RefSeq, PubMed]; Upregulated in blood, spleen, and bone marrow in IgA nephropathy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060218 hematopoietic stem cell differentiation;GO:0001819 positive regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A7E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A9I3-1", "uniprot_id": "FLOWR_RAT", "mass": 18414.0, "length": 171, "protein_name": "Calcium channel flower homolog", "gene_name": "Cacfd1", "organism": "Rat", "refseq_name": "calcium channel flower homolog", "refseq_ac": "NP_001100031", "gene_names_uniprotkb": "Cacfd1", "gene_names_refseq": "Cacfd1; Fwe2; Fwe; RGD1311501", "protein_names_uniprotkb": "Calcium channel flower homolog; Calcium channel flower domain-containing protein 1", "protein_names_refseq": "calcium channel flower domain-containing protein 1; calcium channel flower homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:296599)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22813738;28414717", "class_list": "", "function": "The role of Fwe protein isoform 2 in endocytosis in hippocampal neurons Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (By similarity). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin-mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (PubMed:28414717). In cytotoxic T-lymphocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules (CGs) at the immuno synapse (By similarity). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0031982 vesicle;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A9I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AC13-1", "uniprot_id": "LGR5_RAT", "mass": 99958.0, "length": 907, "protein_name": "Leucine-rich repeat-containing G protein-coupled receptor 5", "gene_name": "Lgr5", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing G-protein coupled receptor 5 precursor", "refseq_ac": "NP_001100254", "gene_names_uniprotkb": "Lgr5", "gene_names_refseq": "Gpr49; Lgr5", "protein_names_uniprotkb": "Leucine-rich repeat-containing G protein-coupled receptor 5", "protein_names_refseq": "G protein-coupled receptor 49; leucine-rich repeat-containing G-protein coupled receptor 5 precursor", "tax_id": 10116, "disease": "ankyloglossia (Disease Ontology:DOID:0060604)", "pathway": " (rno:299802); (R-RNO-4641263)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "26582901;27339869;29018960", "class_list": "", "function": "IL-6 expression increased in all groups compared to control. Lgr5 expression was up-regulated in cells exposed to a single stressor, but down-regulated when multiple stressors were administered., [RefSeq, PubMed]; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer., [RefSeq, PubMed]; That Leucine-rich repeat-containing G-protein coupled receptor 5might be of great significance in CNS pathophysiology after spinal cord injury, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016500 protein-hormone receptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0009994 oocyte differentiation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation;GO:0001942 hair follicle development;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4AC13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09028-1", "uniprot_id": "GBRP_RAT", "mass": 50481.0, "length": 440, "protein_name": "Gamma-aminobutyric acid receptor subunit pi", "gene_name": "Gabrp", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit pi precursor", "refseq_ac": "NP_112291", "gene_names_uniprotkb": "Gabrp", "gene_names_refseq": "Gabrp", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit pi; GABA(A) receptor subunit pi; GABAAR subunit pi", "protein_names_refseq": "GABA(A) receptor subunit pi; GABA-A receptor pi subunit; GABAAR subunit pi; gamma-aminobutyric acid (GABA-A) receptor, pi; gamma-aminobutyric acid A receptor, pi; gamma-aminobutyric acid receptor subunit pi precursor; gamma-aminobutyric acid receptor subunit pi; gamma-aminobutyric acid type A receptor pi subunit", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:81658)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15184050;17003036;17187413;9182563", "class_list": "", "function": "Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (PubMed:17003036). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:17003036). Pi-containing GABAARs are mostly located in peripheral tissues (PubMed:17003036). In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone (By similarity). In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride (PubMed:17003036)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Specifically expressed in alveolar epithelial type II cells; could be used as potential alveolar epithelial cell type II marker for studying lung epithelial cell biology and monitoring lung injury, [RefSeq, PubMed]; We identified novel cell surface markers specific for hepatic progenitor/oval cells. Six are unique for the adult progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp)., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;1.11.1.-;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0016324 apical plasma membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O09028-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46101-1", "uniprot_id": "DPP6_RAT", "mass": 97302.0, "length": 859, "protein_name": "A-type potassium channel modulatory protein DPP6", "gene_name": "Dpp6", "organism": "Rat", "refseq_name": "A-type potassium channel modulatory protein DPP6", "refseq_ac": "NP_074041", "gene_names_uniprotkb": "Dpp6", "gene_names_refseq": "DPP VI; Dpp6", "protein_names_uniprotkb": "A-type potassium channel modulatory protein DPP6; DPP VI; DPPX; Dipeptidyl aminopeptidase-like protein 6; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV-like protein; Dipeptidyl peptidase VI", "protein_names_refseq": "A-type potassium channel modulatory protein DPP6; DPPX; dipeptidyl aminopeptidase-like protein 6; dipeptidyl aminopeptidase-related protein; dipeptidyl peptidase IV-like protein; dipeptidyl peptidase VI; dipeptidylpeptidase 6; dipeptidylpeptidase VI", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 33 (Disease Ontology:DOID:0070063); spinal muscular atrophy (Disease Ontology:DOID:12377); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (rno:29272)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1039/D0MO00044B;12575952;16123112;1729689;19279261;19901547;22675523;23912628;24090084;34106099;38843836", "class_list": "", "function": "A novel component of A-type K(+) channels, [RefSeq, PubMed]; Dipeptidyl-peptidase 6 has an unexpected but important role in cell adhesion and motility, impacting the hippocampal synaptic development and function., [RefSeq, PubMed]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:12575952, PubMed:16123112, PubMed:19279261, PubMed:19901547). Modulates the activity and gating characteristics of the potassium channel KCND2 amd KCND3 (PubMed:12575952, PubMed:16123112, PubMed:19279261, PubMed:19901547). Promotes cell surface expression of the potassium channel KCND2 (PubMed:12575952). Has no dipeptidyl aminopeptidase activity (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The unique N-terminus of DPP6K modulates the effects of KChIP proteins, slowing recovery and producing a negative shift in the steady-state inactivation curve., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 18, "disease_count": 3, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006508 proteolysis;GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P46101-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50572-1", "uniprot_id": "GBRR1_RAT", "mass": 55532.0, "length": 480, "protein_name": "Gamma-aminobutyric acid receptor subunit rho-1", "gene_name": "Gabrr1", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit rho-1 precursor", "refseq_ac": "NP_058987", "gene_names_uniprotkb": "Gabrr1", "gene_names_refseq": "Gabrr1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit rho-1; GABA(A) receptor subunit rho-1; GABA(C) receptor; GABAAR subunit rho-1", "protein_names_refseq": "GABA(A) receptor subunit rho-1; GABA(C) receptor; GABAAR subunit rho-1; gamma-aminobutyric acid (GABA) A receptor, rho 1; gamma-aminobutyric acid (GABA) receptor, rho 1; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1; gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1; gamma-aminobutyric acid A receptor, rho 1; gamma-aminobutyric acid receptor subunit rho-1 precursor; gamma-aminobutyric acid receptor subunit rho-1; gamma-aminobutyric acid type A receptor rho 1 subunit", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:29694); (R-RNO-977443)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11891787;12431995;18385542;19198818;19902194;23935098;29253887;8524843;8905713", "class_list": "", "function": "GABACR and mGluR1 have roles in contrast response functions of Sprague-Dawley and P23H rat retinal ganglion cells Publication Status: Online-Only, [RefSeq, PubMed]; GABAergic neurons in the SGS express GABAC receptors whereas the majority of tectothalamic CB-ir neurons and intrinsicall, [RefSeq, PubMed]; Gabrr1 containing gamma2(R43Q) are addressed to the cell membrane but undergo clathrin-mediated dynamin-dependent endocytosis, [RefSeq, PubMed]; In the stratum griseum superficiale, primarily GABAergic neurons express GABA(C) receptors. Erratum:[Exp Brain Res. 2009 Dec;199(3-4):253. Wahle, Petra [corrected to Wahle, P]; Schmidt, Matthias [removed]], [RefSeq, PubMed]; Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:8524843, PubMed:8905713). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:8524843, PubMed:8905713). Rho-1 subunits are primarily expressed in retina where rho-1-containing GABAARs may play a role in retinal neurotransmission (By similarity). Rho-1 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Suggest that GABA(C)-receptor rho subunit stimulation activates PKA via A-kinase anchoring protein 220(AKAP220)., [RefSeq, PubMed]; The rho1 and rho2 products appeared to be developmentally regulated; they were found to be more pronounced in adulthood., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;1.11.1.-;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0097708 intracellular vesicle;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P50572-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09760-1", "uniprot_id": "FER_RAT", "mass": 94314.0, "length": 823, "protein_name": "Tyrosine-protein kinase Fer", "gene_name": "Fer", "organism": "Rat", "refseq_name": "tyrosine-protein kinase Fer isoform 2", "refseq_ac": "NP_001382687", "gene_names_uniprotkb": "Fer; Fert2; Flk", "gene_names_refseq": "Fert2; Fer; Flk_retired; Flk", "protein_names_uniprotkb": "Tyrosine-protein kinase Fer; 2.7.10.2; Proto-oncogene c-Fer; Tyrosine-protein kinase FLK; p94-Fer", "protein_names_refseq": "c-FER; fer (fms/fps related) protein kinase, testis specific 2; fer (fps/fes related) tyrosine kinase; p94-FER; proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase FER; tyrosine protein kinase FLK; tyrosine-protein kinase Fer isoform 2; tyrosine-protein kinase Fer", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-1433557)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19047464;21122136;2485255", "class_list": "", "function": "Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this clearly depends on cell type and stimulus (By similarity). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MA12", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.10.2;2.7.12.2;2.7.1.40;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.32;2.7.1.82;2.7.11.23;2.7.11.17;2.4.99.18", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0006468 protein phosphorylation;GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P09760-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54838-1", "uniprot_id": "DUS5_RAT", "mass": 42094.0, "length": 384, "protein_name": "Dual specificity protein phosphatase 5", "gene_name": "Dusp5", "organism": "Rat", "refseq_name": "dual specificity protein phosphatase 5", "refseq_ac": "NP_598262", "gene_names_uniprotkb": "Dusp5", "gene_names_refseq": "Cpg21; Dusp5", "protein_names_uniprotkb": "Dual specificity protein phosphatase 5; 3.1.3.16; 3.1.3.48; MAP-kinase phosphatase CPG21", "protein_names_refseq": "MAP-kinase phosphatase (cpg21); MAP-kinase phosphatase CPG21; candidate plasticity-related gene 21; dual specificity protein phosphatase 5", "tax_id": 10116, "disease": "", "pathway": " (rno:171109); (R-RNO-112409); (R-RNO-5675221)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16940436;21828247;29393594;32480039;33361528;33744332;34944046;38200357;9699150", "class_list": "", "function": "Characterization of Type 1 Angiotensin II Receptor Activation Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes in Rat Vascular Smooth Muscle Cells. Publication Status: Online-Only, [RefSeq, PubMed]; DUSP5 suppresses interleukin-1beta-induced chondrocyte inflammation and ameliorates osteoarthritis in rats., [RefSeq, PubMed]; Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1., [RefSeq, PubMed]; Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Impact of knockout of dual-specificity protein phosphatase 5 on structural and mechanical properties of rat middle cerebral arteries: implications for vascular aging., [RefSeq, PubMed]; Intrauterine growth retardation affects hippocampal DUSP5 expression and epigenetic characteristics in a sex-specific manner., [RefSeq, PubMed]; Intrauterine growth retardation induced by uteroplacental insufficiency 1) affects the hepatic epigenetic characteristics and mRNA of the DUSP-5 and 2) increases hepatic insulin receptor substrate-1 phosphorylation at serine 612 in adult rats., [RefSeq, PubMed]; MiR-363-3p attenuates neonatal hypoxic-ischemia encephalopathy by targeting DUSP5., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.16;2.7.10.1;3.1.3.53;3.1.3.2;3.1.3.52;3.1.3.21;3.1.3.18;3.1.3.67;3.1.3.-;3.1.3.27;3.1.3.5;2.7.11.24;2.7.11.22;3.1.3.74", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016311 dephosphorylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0045892 negative regulation of DNA-templated transcription;GO:0045906 negative regulation of vasoconstriction;GO:0001706 endoderm formation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O54838-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22443-1", "uniprot_id": "CP19A_RAT", "mass": 58412.0, "length": 508, "protein_name": "Aromatase", "gene_name": "Cyp19a1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cyp19a1; Arom; Cyp19", "gene_names_refseq": "", "protein_names_uniprotkb": "Aromatase; 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase", "protein_names_refseq": "", "tax_id": 10116, "disease": "aromatase excess syndrome (Disease Ontology:DOID:0090122); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); protein-energy malnutrition (Disease Ontology:DOID:11801); urethral obstruction (Disease Ontology:DOID:12577); Sjogren's syndrome (Disease Ontology:DOID:12894); endometrial cancer (Disease Ontology:DOID:1380); bladder neck obstruction (Disease Ontology:DOID:13948); hypothyroidism (Disease Ontology:DOID:1459); prostatitis (Disease Ontology:DOID:14654); breast cancer (Disease Ontology:DOID:1612); disorder of sexual development (Disease Ontology:DOID:1923); ovarian cancer (Disease Ontology:DOID:2394); endometriosis (Disease Ontology:DOID:289); placental insufficiency (Disease Ontology:DOID:3891); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myocardial infarction (Disease Ontology:DOID:5844); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:25147); (R-RNO-193144); (R-RNO-211976)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "2157976;2340950", "class_list": "", "function": "Catalyzes the formation of aromatic C18 estrogens from C19 androgens., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.14", "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395 steroid hydroxylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0043195 terminal bouton;GO:0043197 dendritic spine", "go_biological_process": "GO:0002677 negative regulation of chronic inflammatory response;GO:0006710 androgen catabolic process;GO:2000866 positive regulation of estradiol secretion;GO:0097720 calcineurin-mediated signaling;GO:0030851 granulocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P22443-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LR10-1", "uniprot_id": "LIMA1_RAT", "mass": 83797.0, "length": 755, "protein_name": "LIM domain and actin-binding protein 1", "gene_name": "Lima1", "organism": "Rat", "refseq_name": "LIM domain and actin-binding protein 1", "refseq_ac": "NP_001178544", "gene_names_uniprotkb": "Lima1; eplin", "gene_names_refseq": "Lima1; eplin", "protein_names_uniprotkb": "LIM domain and actin-binding protein 1; Epithelial protein lost in neoplasm", "protein_names_refseq": "LIM domain and actin-binding protein 1; epithelial protein lost in neoplasm", "tax_id": 10116, "disease": "", "pathway": " (rno:300228)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16641100;22673903;24694988;29393594", "class_list": "", "function": "Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Acts as a negative regulator of primary cilium formation (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V8I6", "ec_number_list": "", "go_molecular_function": "GO:0003785 actin monomer binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0140778 microtubule stabilizing activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005925 focal adhesion", "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization;GO:1902018 negative regulation of cilium assembly;GO:0032233 positive regulation of actin filament bundle assembly;GO:0008203 cholesterol metabolic process;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1LR10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23512-1", "uniprot_id": "FOXA1_RAT", "mass": 48775.0, "length": 466, "protein_name": "Hepatocyte nuclear factor 3-alpha", "gene_name": "Foxa1", "organism": "Rat", "refseq_name": "hepatocyte nuclear factor 3-alpha", "refseq_ac": "NP_036874", "gene_names_uniprotkb": "Foxa1; Hnf3a; Tcf-3a; Tcf3a", "gene_names_refseq": "Foxa1; Hnf3a", "protein_names_uniprotkb": "Hepatocyte nuclear factor 3-alpha; Forkhead box protein A1; HNF-3-alpha; HNF-3A", "protein_names_refseq": "HNF-3-alpha; HNF-3A; forkhead box protein A1; hepatocyte nuclear factor 3-alpha", "tax_id": 10116, "disease": "brain glioma (Disease Ontology:DOID:0060108); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); colon carcinoma (Disease Ontology:DOID:1520); breast cancer (Disease Ontology:DOID:1612); colon adenocarcinoma (Disease Ontology:DOID:234); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); esophagus adenocarcinoma (Disease Ontology:DOID:4914); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25098); (R-RNO-9018519)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12750453;15358835;17189638;17220277;18178153;2227418;22673903;33629893;35976271;37217807", "class_list": "", "function": "Foxa1 mediates eccrine sweat gland development through transcriptional regulation of Na-K-ATPase expression. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA NKILA Exacerbates Alzheimer's Disease Progression by Regulating the FOXA1-Mediated Transcription of TNFAIP1., [RefSeq, PubMed]; Silencing of long noncoding RNA H19 alleviates pulmonary injury, inflammation, and fibrosis of acute respiratory distress syndrome through regulating the microRNA-423-5p/FOXA1 axis., [RefSeq, PubMed]; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Involved in glucose homeostasis; activates the GCG promoter. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, lungs and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles. Modulates the transcriptional activity of nuclear hormone receptors. Is required for maximal gene activation mediated by AR in the prostate. Negatively regulates AR transactivation via competition with coactivators such as NCOA2. Is involved in ESR1-mediated transcription. Involved in regulation of apoptosis. Involved in cell cycle regulation. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005902 microvillus", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0060743 epithelial cell maturation involved in prostate gland development;GO:0060638 mesenchymal-epithelial cell signaling;GO:0060741 prostate gland stromal morphogenesis;GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P23512-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04823-1", "uniprot_id": "IL3_RAT", "mass": 18631.0, "length": 166, "protein_name": "Interleukin-3", "gene_name": "Il3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Il3; Il-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-3; Hematopoietic growth factor; IL-3; MCGF; Mast cell growth factor; Multipotential colony-stimulating factor; P-cell-stimulating factor", "protein_names_refseq": "", "tax_id": 10116, "disease": "Graves ophthalmopathy (Disease Ontology:DOID:0081120); Alzheimer's disease (Disease Ontology:DOID:10652); prostatic hypertrophy (Disease Ontology:DOID:11132); pyelonephritis (Disease Ontology:DOID:11400); Graves' disease (Disease Ontology:DOID:12361); gonadal dysgenesis (Disease Ontology:DOID:14447); major depressive disorder (Disease Ontology:DOID:1470); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); osteosarcoma (Disease Ontology:DOID:3347); Ebola virus disease (Disease Ontology:DOID:4325); rheumatoid arthritis (Disease Ontology:DOID:7148); genital herpes (Disease Ontology:DOID:8704); psoriasis (Disease Ontology:DOID:8893); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24495); (R-RNO-512988); (R-RNO-5673001); (R-RNO-912526)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "3086845;9747458", "class_list": "", "function": "Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P70513", "ec_number_list": "", "go_molecular_function": "GO:0005135 interleukin-3 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0033026 negative regulation of mast cell apoptotic process;GO:0035162 embryonic hemopoiesis;GO:0038156 interleukin-3-mediated signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0006110 regulation of glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04823-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52590-1", "uniprot_id": "NU107_RAT", "mass": 107209.0, "length": 926, "protein_name": "Nuclear pore complex protein Nup107", "gene_name": "Nup107", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nup107", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear pore complex protein Nup107; 107 kDa nucleoporin; Nucleoporin Nup107; p105", "protein_names_refseq": "", "tax_id": 10116, "disease": "nephrotic syndrome type 11 (Disease Ontology:DOID:0080385); ovarian dysgenesis 6 (Disease Ontology:DOID:0080498); Galloway-Mowat syndrome (Disease Ontology:DOID:0080694); 46 XX gonadal dysgenesis (Disease Ontology:DOID:14450)", "pathway": " (rno:116555); (R-RNO-141430); (R-RNO-141444); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9615933); (R-RNO-9648025)", "pathway_count": 26, "publication_count": 2, "publication_id_list": "22673903;8021268", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0000776 kinetochore", "go_biological_process": "GO:0072006 nephron development;GO:0006406 mRNA export from nucleus;GO:0008585 female gonad development;GO:0051292 nuclear pore complex assembly;GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P52590-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00714-1", "uniprot_id": "LALBA_RAT", "mass": 17850.0, "length": 159, "protein_name": "Alpha-lactalbumin", "gene_name": "Lalba", "organism": "Rat", "refseq_name": "alpha-lactalbumin precursor", "refseq_ac": "NP_036726", "gene_names_uniprotkb": "Lalba", "gene_names_refseq": "Lalba", "protein_names_uniprotkb": "Alpha-lactalbumin; Lactose synthase B protein", "protein_names_refseq": "alpha-lactalbumin precursor; alpha-lactalbumin; lactose synthase B protein", "tax_id": 10116, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); gastroenteritis (Disease Ontology:DOID:2326); tetralogy of Fallot (Disease Ontology:DOID:6419); viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (rno:24528)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18462607;6272279;6709045;7044414", "class_list": "", "function": "Mammary tissue from late pregnant Restricted rats had elevated alpha-lactalbumin, but not beta-casein mRNA., [RefSeq, PubMed]; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P00715", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003796 lysozyme activity;GO:0004461 lactose synthase activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex;GO:0005576 extracellular region", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0005989 lactose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00714-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54728-1", "uniprot_id": "PLB1_RAT", "mass": 161089.0, "length": 1450, "protein_name": "Phospholipase B1, membrane-associated", "gene_name": "Plb1", "organism": "Rat", "refseq_name": "phospholipase B1, membrane-associated precursor", "refseq_ac": "NP_620253", "gene_names_uniprotkb": "Plb1; Phlpb", "gene_names_refseq": "Phlpb; Plb1", "protein_names_uniprotkb": "Phospholipase B1, membrane-associated; 3.1.1.3; 3.1.1.4; 3.1.1.5; Lysophospholipase; PLB/LIP; Phospholipase A2; Phospholipase B/lipase; Phospholipase B; Triacylglycerol lipase", "protein_names_refseq": "PLB/LIP; lysophospholipase; phospholipase A2; phospholipase B/lipase; phospholipase B1, membrane-associated precursor; phospholipase B1, membrane-associated; triacylglycerol lipase", "tax_id": 10116, "disease": "", "pathway": " (rno:192259); (R-RNO-1482788); (R-RNO-975634)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11401559;1716922;9442064;9442065", "class_list": "", "function": "Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids (PubMed:11401559, PubMed:9442064, PubMed:9442065). Preferentially cleaves sn-2 ester bonds over sn-1 bonds (PubMed:9442064). Acts as a lipase toward glycerolipid substrates (PubMed:11401559, PubMed:9442064, PubMed:9442065). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (PubMed:11401559, PubMed:9442064, PubMed:9442065). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (Probable)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.3;3.1.1.4;3.1.1.32;2.3.1.-;2.3.1.51;3.1.1.-;3.1.1.5;3.1.1.23;3.1.1.79;3.1.1.6;1.11.1.27;2.3.1.23;3.5.1.1;3.1.1.47;3.1.1.13;3.1.1.116;2.3.1.43;3.1.1.26;3.1.2.22;3.1.2.-;2.3.1.149;3.1.2.2;3.1.1.34;3.1.1.111;3.1.-.-", "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity", "go_cellular_component": "GO:0031526 brush border membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0046338 phosphatidylethanolamine catabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0042572 retinol metabolic process;GO:0046340 diacylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O54728-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36380-1", "uniprot_id": "CXB4_RAT", "mass": 30352.0, "length": 265, "protein_name": "Gap junction beta-4 protein", "gene_name": "Gjb4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gjb4; Cxn-30.3", "gene_names_refseq": "", "protein_names_uniprotkb": "Gap junction beta-4 protein; Connexin-30.3; Cx30.3", "protein_names_refseq": "", "tax_id": 10116, "disease": "erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); erythrokeratodermia variabilis et progressiva 2 (Disease Ontology:DOID:0080248)", "pathway": " (rno:117055); (R-RNO-190861)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20184948;7517368", "class_list": "", "function": "Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0005922 connexin complex", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007267 cell-cell signaling;GO:0007608 sensory perception of smell;GO:1990349 gap junction-mediated intercellular transport;GO:0007154 cell communication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P36380-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88984-1", "uniprot_id": "NXF1_RAT", "mass": 70362.0, "length": 618, "protein_name": "Nuclear RNA export factor 1", "gene_name": "Nxf1", "organism": "Rat", "refseq_name": "nuclear RNA export factor 1", "refseq_ac": "NP_067590", "gene_names_uniprotkb": "Nxf1; Tap", "gene_names_refseq": "Mex67h; Nxf1; Tap", "protein_names_uniprotkb": "Nuclear RNA export factor 1; Tip-associated protein; Tip-associating protein; mRNA export factor TAP", "protein_names_refseq": "mRNA export factor TAP; nuclear RNA export factor 1 homolog; nuclear RNA export factor 1; tip-associated protein; tip-associating protein", "tax_id": 10116, "disease": "", "pathway": " (rno:59087); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0042272 nuclear RNA export factor complex;GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0015031 protein transport;GO:0006405 RNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O88984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07338-1", "uniprot_id": "CTRB1_RAT", "mass": 27849.0, "length": 263, "protein_name": "Chymotrypsinogen B", "gene_name": "Ctrb1", "organism": "Rat", "refseq_name": "chymotrypsinogen B precursor", "refseq_ac": "NP_036668", "gene_names_uniprotkb": "Ctrb1; Ctrb", "gene_names_refseq": "Ctrb1; Ctrb", "protein_names_uniprotkb": "Chymotrypsinogen B; 3.4.21.1", "protein_names_refseq": "Chymotrypsin B; Chymotrypsinogen B; chymotrypsin B1; chymotrypsinogen B precursor", "tax_id": 10116, "disease": "pancreatitis (Disease Ontology:DOID:4989); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:24291); (R-RNO-1592389)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18211899;6209274", "class_list": "", "function": "Chymotrypsin B is not only restricted to the pancreas but can function intracellularly as a pro-apoptotic protease, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.4;3.4.24.17;3.4.24.22;3.4.21.1;3.4.21.34;3.4.21.20;3.4.24.35", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007584 response to nutrient;GO:0043065 positive regulation of apoptotic process;GO:0032094 response to food;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P07338-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V645-1", "uniprot_id": "OASL1_RAT", "mass": 58968.0, "length": 512, "protein_name": "2'-5'-oligoadenylate synthase-like protein 1", "gene_name": "Oasl", "organism": "Rat", "refseq_name": "2'-5'-oligoadenylate synthase-like protein 1", "refseq_ac": "NP_001009681", "gene_names_uniprotkb": "Oasl", "gene_names_refseq": "Oasl1; Oasl", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthase-like protein 1", "protein_names_refseq": "2'-5' oligoadenylate synthetase-like 1; 2'-5'-oligoadenylate synthase-like protein 1; 59 kDa 2'-5'-oligoadenylate synthase-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:304545); (R-RNO-8983711)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17024523", "class_list": "", "function": "Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5MYW3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003725 double-stranded RNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway;GO:0009615 response to virus;GO:1900246 positive regulation of RIG-I signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V645-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53669-1", "uniprot_id": "LIMK1_RAT", "mass": 72594.0, "length": 647, "protein_name": "LIM domain kinase 1", "gene_name": "Limk1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Limk1; Limk", "gene_names_refseq": "", "protein_names_uniprotkb": "LIM domain kinase 1; 2.7.11.1; LIMK-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (rno:65172); (R-RNO-2029482); (R-RNO-399954); (R-RNO-5627123)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "15660133;16204183;7651734;9685409", "class_list": "", "function": "Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;3.6.4.10;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;3.6.5.2;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0006468 protein phosphorylation;GO:0030036 actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly;GO:0045773 positive regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P53669-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97885-1", "uniprot_id": "CXCL5_RAT", "mass": 14263.0, "length": 130, "protein_name": "C-X-C motif chemokine 5", "gene_name": "Cxcl5; Cxcl6", "organism": "Rat", "refseq_name": "C-X-C motif chemokine 5 precursor", "refseq_ac": "NP_071550", "gene_names_uniprotkb": "Cxcl5; Cxcl6; Cxcl5; Scyb5", "gene_names_refseq": "Cxcl5; Cxcl6", "protein_names_uniprotkb": "C-X-C motif chemokine 5; Cytokine LIX; Small-inducible cytokine B5", "protein_names_refseq": "C-X-C motif chemokine 5 precursor; C-X-C motif chemokine 5; CXC chemokine LIX; chemokine (C-X-C motif) ligand 5; chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2); cytokine LIX; small-inducible cytokine B5", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); obstructive sleep apnea (Disease Ontology:DOID:0050848); alcohol-associated liver disease (Disease Ontology:DOID:0070658); common cold (Disease Ontology:DOID:10459); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary sarcoidosis (Disease Ontology:DOID:13406); prostatitis (Disease Ontology:DOID:14654); colon carcinoma (Disease Ontology:DOID:1520); diffuse scleroderma (Disease Ontology:DOID:1580); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483); pneumonia (Disease Ontology:DOID:552); colorectal cancer (Disease Ontology:DOID:9256); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (rno:60665); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "29126185;33741291;33752504;33810797", "class_list": "", "function": "CRH suppressed CXCL5 production in glia via CRHR1 in the hippocampus of male rats., [RefSeq, PubMed]; CXCL5 Cytokine Is a Major Factor in Platelet-Rich Plasma's Preservation of Erectile Function in Rats After Bilateral Cavernous Nerve Injury., [RefSeq, PubMed]; Expression and potential role of CXCL5 in the pathogenesis of intrauterine adhesions., [RefSeq, PubMed]; May participate in the recruitment of inflammatory cells by injured or infected tissue., [UniProtKB]; Spatial learning and memory deficits induced by prenatal glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5 signaling in rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0010332 response to gamma radiation;GO:0010976 positive regulation of neuron projection development;GO:0032496 response to lipopolysaccharide;GO:0032642 regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97885-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02773-1", "uniprot_id": "FETA_RAT", "mass": 68386.0, "length": 611, "protein_name": "Alpha-fetoprotein", "gene_name": "Afp", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Afp", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); hepatitis C (Disease Ontology:DOID:1883); endodermal sinus tumor (Disease Ontology:DOID:1911); hepatitis (Disease Ontology:DOID:2237); teratocarcinoma (Disease Ontology:DOID:3305); embryonal carcinoma (Disease Ontology:DOID:3308); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:24177); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1376990;1722723;2434929;2442163;2582363;6157681;6157690;6167988", "class_list": "", "function": "Binds estrogens, fatty acids and metals., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63032;Q63205", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0001889 liver development;GO:0006955 immune response;GO:0071300 cellular response to retinoic acid;GO:0006915 apoptotic process;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P02773-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23999-1", "uniprot_id": "MYCS_RAT", "mass": 47002.0, "length": 429, "protein_name": "Protein S-Myc", "gene_name": "Mycs", "organism": "Rat", "refseq_name": "protein S-Myc", "refseq_ac": "NP_068609", "gene_names_uniprotkb": "Mycs", "gene_names_refseq": "Mycs", "protein_names_uniprotkb": "Protein S-Myc", "protein_names_refseq": "protein S-Myc", "tax_id": 10116, "disease": "X-linked chondrodysplasia punctata 1 (Disease Ontology:DOID:0060292); Feingold syndrome (Disease Ontology:DOID:0060464); X-linked chondrodysplasia punctata 2 (Disease Ontology:DOID:0080352); MEND syndrome (Disease Ontology:DOID:0111865); chondrodysplasia punctata (Disease Ontology:DOID:2581)", "pathway": " (rno:24581)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12145275;2594755", "class_list": "", "function": "Genes are idenetified that are regulated by Myc genes, [RefSeq, PubMed]; Has apoptosis-inducing activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P23999-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50609-1", "uniprot_id": "FMOD_RAT", "mass": 43219.0, "length": 376, "protein_name": "Fibromodulin", "gene_name": "Fmod", "organism": "Rat", "refseq_name": "fibromodulin precursor", "refseq_ac": "NP_542429", "gene_names_uniprotkb": "Fmod", "gene_names_refseq": "Fmod", "protein_names_uniprotkb": "Fibromodulin; Collagen-binding 59 kDa protein; FM; KSPG fibromodulin; Keratan sulfate proteoglycan fibromodulin", "protein_names_refseq": "FM; KSPG fibromodulin; collagen-binding 59 kDa protein; fibromodulin precursor; keratan sulfate proteoglycan fibromodulin", "tax_id": 10116, "disease": "gingivitis (Disease Ontology:DOID:3087); periodontitis (Disease Ontology:DOID:824); tendinitis (Disease Ontology:DOID:971)", "pathway": " (rno:64507); (R-RNO-2022854); (R-RNO-2022857)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "27665369;37904680;38172726", "class_list": "", "function": "Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity)., [UniProtKB]; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis., [UniProtKB, UniProtKB, UniProtKB]; Downregulation of fibromodulin attenuates inflammatory signaling and atrial fibrosis in spontaneously hypertensive rats with atrial fibrillation via inhibiting TLR4/NLRP3 signaling pathway., [RefSeq, PubMed]; The fibromodulin (Fm)-transforming growth factor (TGF)-beta1 nexus plays a crucial in fetal-type scarless skin repair., [RefSeq, PubMed]; Transfer RNA-derived small RNA tRF-Glu-CTC attenuates neointimal formation via inhibition of fibromodulin. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0042475 odontogenesis of dentin-containing tooth;GO:0043588 skin development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50609-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08812-1", "uniprot_id": "CTR3_RAT", "mass": 67525.0, "length": 619, "protein_name": "Cationic amino acid transporter 3", "gene_name": "Slc7a3", "organism": "Rat", "refseq_name": "cationic amino acid transporter 3", "refseq_ac": "NP_058913", "gene_names_uniprotkb": "Slc7a3; Atrc3; Cat3", "gene_names_refseq": "Atrc3; Cat3; Slc7a2; Slc7a3; cat-3", "protein_names_uniprotkb": "Cationic amino acid transporter 3; CAT-3; CAT3; Cationic amino acid transporter y+; Solute carrier family 7 member 3", "protein_names_refseq": "amino acid transporter, cationic 3; cationic amino acid transporter 3; cationic amino acid transporter y+; solute carrier family 7 (cationic amino acid transporter, y+ system), member 3", "tax_id": 10116, "disease": "", "pathway": " (rno:29485); (R-RNO-352230)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17234578;9079705", "class_list": "", "function": "The influence of NMDA receptor activation on mammalian target of rapamycin (mTOR) activity and neuronal process extension is mediated by CAT3., [RefSeq, PubMed]; Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:9079705). The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion (PubMed:9079705)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000064 L-ornithine transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015174 basic amino acid transmembrane transporter activity;GO:0015189 L-lysine transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0032006 regulation of TOR signaling;GO:0097638 L-arginine import across plasma membrane;GO:0097639 L-lysine import across plasma membrane;GO:0097640 L-ornithine import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08812-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25115-1", "uniprot_id": "DRD5_RAT", "mass": 52831.0, "length": 475, "protein_name": "D(1B) dopamine receptor", "gene_name": "Drd5", "organism": "Rat", "refseq_name": "D(1B) dopamine receptor", "refseq_ac": "NP_036900", "gene_names_uniprotkb": "Drd5", "gene_names_refseq": "D1B; Drd5", "protein_names_uniprotkb": "D(1B) dopamine receptor; D(5) dopamine receptor; Dopamine D5 receptor", "protein_names_refseq": "D(1B) dopamine receptor; d(5) dopamine receptor; dopamine D5 receptor; dopamine receptor 5", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); pervasive developmental disorder (Disease Ontology:DOID:0060040); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); blepharospasm (Disease Ontology:DOID:529)", "pathway": " (rno:25195); (R-RNO-390651)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1831904;28336436;29537707;34064454;34881789;35478421", "class_list": "", "function": "Characterization of the Functional Cross-Talk between Surface GABAA and Dopamine D5 Receptors. Publication Status: Online-Only, [RefSeq, PubMed]; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase., [UniProtKB, UniProtKB, UniProtKB]; Expression of D5 dopamine receptors in the lateral ventricle walls during post-weaning rat development., [RefSeq, PubMed]; Frequency-dependency of the involvement of dopamine D1/D5 and beta-adrenergic receptors in hippocampal LTD triggered by locus coeruleus stimulation., [RefSeq, PubMed]; Results suggest that the dynamic range of D1/D5 receptor-mediated dopamine effects on LTP may be higher in ventral hippocampus than dorsal hippocampus and that ventral hippocampus may be specialized to acquire information about behaviorally relevant strong stimuli signaled by the dopamine system., [RefSeq, PubMed]; The results suggest that dopamine receptors in the retinal cells might actively respond to the environmental lighting to act as an important player in the activation of the dopaminergic system in the ocular structures relevant to the lighting-induced pathogenic development of myopia., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004952 dopamine neurotransmitter receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0001965 G-protein alpha-subunit binding;GO:0035240 dopamine binding;GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007617 mating behavior;GO:0008306 associative learning;GO:0008542 visual learning;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P25115-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01205-1", "uniprot_id": "ODO2_RAT", "mass": 48925.0, "length": 454, "protein_name": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "gene_name": "Dlst", "organism": "Rat", "refseq_name": "dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "refseq_ac": "NP_001006982", "gene_names_uniprotkb": "Dlst", "gene_names_refseq": "Dlst", "protein_names_uniprotkb": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2; 2.3.1.61; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K; OGDC-E2", "protein_names_refseq": "2-oxoglutarate dehydrogenase complex component E2; E2K; E2; OGDC-E2; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "tax_id": 10116, "disease": "pheochromocytoma/paraganglioma syndrome 7 (Disease Ontology:DOID:0061222); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:299201); (R-RNO-6783984); (R-RNO-9853506); (R-RNO-9857492); (R-RNO-9858328)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "1918017;26446791", "class_list": "", "function": "Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5XI35", "ec_number_list": "2.3.1.-;2.3.1.200;2.3.1.61;1.2.4.-;1.2.4.2;1.8.1.4", "go_molecular_function": "GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042383 sarcolemma", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process;GO:0006104 succinyl-CoA metabolic process;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0120551 2-oxoglutarate decarboxylation to succinyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q01205-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88806-1", "uniprot_id": "PADI1_RAT", "mass": 73857.0, "length": 662, "protein_name": "Protein-arginine deiminase type-1", "gene_name": "Padi1", "organism": "Rat", "refseq_name": "protein-arginine deiminase type-1", "refseq_ac": "NP_062205", "gene_names_uniprotkb": "Padi1; Pad1; Pdi1", "gene_names_refseq": "Padi1; Pdi1", "protein_names_uniprotkb": "Protein-arginine deiminase type-1; 3.5.3.15; PAD-R11; Peptidylarginine deiminase I; Protein-arginine deiminase type I", "protein_names_refseq": "PAD-R11; peptidyl arginine deiminase, type 1; peptidyl arginine deiminase, type I; peptidylarginine deiminase I; protein-arginine deiminase type I; protein-arginine deiminase type-1", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849); candidiasis (Disease Ontology:DOID:1508); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (rno:54282); (R-RNO-3247509)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9738944", "class_list": "", "function": "Catalyzes the deimination of arginine residues of proteins., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.3.15", "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88806-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19492-1", "uniprot_id": "GRIA3_RAT", "mass": 100373.0, "length": 888, "protein_name": "Glutamate receptor 3", "gene_name": "Gria3", "organism": "Rat", "refseq_name": "glutamate receptor 3 isoform 2 precursor", "refseq_ac": "NP_001106213", "gene_names_uniprotkb": "Gria3; GluA3; Glur3", "gene_names_refseq": "GLUR3; GluA3; GluR-3; GluR-C; GluR-K3; Gria3", "protein_names_uniprotkb": "Glutamate receptor 3; AMPA-selective glutamate receptor 3; GluR-3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3", "protein_names_refseq": "AMPA-selective glutamate receptor 3; glutamate receptor 3 isoform 2 precursor; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA 3; glutamate receptor, ionotropic, AMPA3 (alpha 3)", "tax_id": 10116, "disease": "syndromic X-linked intellectual disability 94 (Disease Ontology:DOID:0060823); neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596); central nervous system disease (Disease Ontology:DOID:331); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29628); (R-RNO-399710); (R-RNO-399719); (R-RNO-416993); (R-RNO-438066); (R-RNO-8849932)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "10027300;10414981;12761821;1699275;1699567;1709304;18817736;19003990;19265014;20199107;21317871;2166337;2168579;24090084;25524891;28951554;38843836;9069286", "class_list": "", "function": "Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]., [RefSeq]; Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1699567, PubMed:1709304, PubMed:2166337, PubMed:2168579). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium (PubMed:1709304). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study shows that oxygen and glucose deprivation (OGD) causes endocytosis, lysosomal targeting and consequent degradation of GluA2- and GluA3-containing AMPARs, and that PICK1 is required for both OGD-induced GluA2 endocytosis and lysosomal sorting. GluA1-containing AMPARs resist OGD-induced endocytosis and PICK1 binding to the endocytic adaptor AP2 is enhanced by OGD in hippocampal, but not cortical neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0001540 amyloid-beta binding;GO:0004970 glutamate-gated receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0035249 synaptic transmission, glutamatergic;GO:0001919 regulation of receptor recycling;GO:0010226 response to lithium ion;GO:0051290 protein heterotetramerization", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P19492-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29414-1", "uniprot_id": "CXA3_RAT", "mass": 46013.0, "length": 416, "protein_name": "Gap junction alpha-3 protein", "gene_name": "Gja3", "organism": "Rat", "refseq_name": "gap junction alpha-3 protein", "refseq_ac": "NP_077352", "gene_names_uniprotkb": "Gja3; Cxn-46", "gene_names_refseq": "Cxnj1; Gja3", "protein_names_uniprotkb": "Gap junction alpha-3 protein; Connexin-46; Cx46", "protein_names_refseq": "connexin j1; connexin-46; cx46; gap junction alpha-3 protein; gap junction membrane channel protein alpha 3", "tax_id": 10116, "disease": "cataract 14 multiple types (Disease Ontology:DOID:0110253); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:79217); (R-RNO-190861)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1659572;21606502;23065326;27143357;29158540;9683738", "class_list": "", "function": "Cx43 and Cx46 have novel functions in regulating each other's expression and turnover in a reciprocal manner in addition to their conventional roles as gap junction proteins in lens cells., [RefSeq, PubMed]; Data provide evidence that the activation and inhibition of PKC affect the rCx46-mediated membrane conductance as well as the voltage-dependent current inactivation in an inverse manner., [RefSeq, PubMed]; In agreement with the model and suggesting a conformational change that narrows the pore, Ca(2+) inhibits the water flux through Cx hemichannels. We conclude that Ca(2+) and voltage act allosterically to stabilize the closed conformation of Cx46 hemichannels. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of lens fiber gap junctions (Probable). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (Probable)., [UniProtKB, PubMed, UniProtKB]; Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore., [UniProtKB, UniProtKB]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response., [UniProtKB, UniProtKB]; The role of the charged residues at the end of TM-1 in voltage sensing in Cx26, Cx46, and Cx50., [RefSeq, PubMed]; These results suggest that the C-terminal region of rCx46 up to A311 (rCx46(35.3)) is necessary for its correct compartmentalization and internalization in the form of annular junctions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0055077 gap junction hemi-channel activity;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0042542 response to hydrogen peroxide;GO:0007601 visual perception;GO:0009268 response to pH;GO:1990349 gap junction-mediated intercellular transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P29414-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02195-1", "uniprot_id": "FGF7_RAT", "mass": 22268.0, "length": 194, "protein_name": "Fibroblast growth factor 7", "gene_name": "Fgf7", "organism": "Rat", "refseq_name": "fibroblast growth factor 7 precursor", "refseq_ac": "NP_071518", "gene_names_uniprotkb": "Fgf7; Fgf-7; Kgf", "gene_names_refseq": "Fgf5b; Fgf7; KGF/FGF7; Kgf", "protein_names_uniprotkb": "Fibroblast growth factor 7; FGF-7; HBGF-7; Heparin-binding growth factor 7; Keratinocyte growth factor", "protein_names_refseq": "FGF-7; HBGF-7; Keratinocyte Growth Factor Fgf-7; fibroblast growth factor 5b; fibroblast growth factor 7 precursor; heparin-binding growth factor 7", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); prostate cancer (Disease Ontology:DOID:10283); prostatic hypertrophy (Disease Ontology:DOID:11132); leiomyoma (Disease Ontology:DOID:127); squamous cell carcinoma (Disease Ontology:DOID:1749); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); severe acute respiratory syndrome (Disease Ontology:DOID:2945); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (rno:29348); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190377); (R-RNO-5654221); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654727); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 11, "publication_count": 8, "publication_id_list": "11724555;16641100;1869483;30858037;30894415;31017714;32586178;34898359", "class_list": "", "function": "Effect of Taspine hydrochloride on the repair of rat skin wounds by regulating keratinocyte growth factor signal., [RefSeq, PubMed]; Findings demonstrate that KGF-1 promotes fibroblast contraction and accelerates wound contraction via the TGF-beta1/Smad signaling pathway in a double-paracrine manner., [RefSeq, PubMed]; Findings illustrate a role for miR-455-3p-1 in modulating FGF7-RAS/ERK signaling and suggest that an agomir of miR-455-3p-1 could inhibit the proliferation of PASMCs and mitigate PAH in vivo., [RefSeq, PubMed]; Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation., [UniProtKB]; MiR-199a-3p inhibits the proliferation, migration, and invasion of endothelial cells and retinal pericytes of diabetic retinopathy rats through regulating FGF7 via EGFR/PI3K/AKT pathway., [RefSeq, PubMed]; Silencing fibroblast growth factor 7 inhibits krypton laser-induced choroidal neovascularization in a rat model., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043129 surfactant homeostasis;GO:0043410 positive regulation of MAPK cascade;GO:0030324 lung development;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q02195-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55165-1", "uniprot_id": "KIF3C_RAT", "mass": 89816.0, "length": 796, "protein_name": "Kinesin-like protein KIF3C", "gene_name": "Kif3c", "organism": "Rat", "refseq_name": "kinesin-like protein KIF3C", "refseq_ac": "NP_445938", "gene_names_uniprotkb": "Kif3c", "gene_names_refseq": "Kif3c", "protein_names_uniprotkb": "Kinesin-like protein KIF3C", "protein_names_refseq": "kinesin-like protein KIF3C", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:85248); (R-RNO-2132295); (R-RNO-5620924); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "9487132;9808286", "class_list": "", "function": "Microtubule-based anterograde translocator for membranous organelles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88657", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0019894 kinesin binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030424 axon;GO:0030425 dendrite;GO:0030426 growth cone", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O55165-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70535-1", "uniprot_id": "LIFR_RAT", "mass": 122394.0, "length": 1093, "protein_name": "Leukemia inhibitory factor receptor", "gene_name": "Lifr", "organism": "Rat", "refseq_name": "leukemia inhibitory factor receptor precursor", "refseq_ac": "NP_112310", "gene_names_uniprotkb": "Lifr", "gene_names_refseq": "Lifr", "protein_names_uniprotkb": "Leukemia inhibitory factor receptor; LIF receptor; LIF-R", "protein_names_refseq": "LIF receptor alpha; LIF-R; leukemia inhibitor factor receptor alpha-chain; leukemia inhibitory factor receptor alpha; leukemia inhibitory factor receptor precursor", "tax_id": 10116, "disease": "congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (rno:81680); (R-RNO-6788467)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21446866;21454685;22291973;23064267;30937308;9349722", "class_list": "", "function": "Continuous orthodontic forces induce the upregulation of production, suggesting that LIFR may play important role in periodontium remodeling, [RefSeq, PubMed]; Functions as a signal-transducing subunit either in complex with IL6ST/gp130 or as part of the ciliary neurotrophic factor receptor (CNTFR) complex composed by CNTFR, IL6ST/gp130 and LIFR. Signal transmission is initiated either by binding directly to cytokines, such as OSM or LIF, or through the binding of other cytokines, like CNTF, CLCF1 or the heterodimeric complex CRLF1-CLCF1 to the non-signaling receptor CNTFR; ligand binding induces heterodimerization of IL6ST/gp130 and LIFR which activates JAK tyrosine kinases bound to their intracellular domains. These kinases subsequently phosphorylate the homodimer or heterodimer form of IL6ST/gp130. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STATs). Engages sites 3 of ligands cytokines., [UniProtKB, UniProtKB]; In the chronic kidney disease-cardiac hypertrophy model exercise rescues cardiac disease via cardiotrophin-1/LIFR/gp 130/JAK/STAT3 pathway., [RefSeq, PubMed]; LIF and its subunit receptor LIFRalpha are constitutively expressed during fetal lung development and that they have an inhibitory physiological role on fetal lung branching., [RefSeq, PubMed]; Lifr plays a pivotal role in the astrocyte apoptosis induced by hypoxic/low-glucose environments. Publication Status: Online-Only, [RefSeq, PubMed]; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 17, "predicted_n_glycosites": 16, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004923 leukemia inhibitory factor receptor activity;GO:0015026 coreceptor activity;GO:0019838 growth factor binding;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0070110 ciliary neurotrophic factor receptor complex;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0038165 oncostatin-M-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0048812 neuron projection morphogenesis;GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70535-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34997-1", "uniprot_id": "CXCR5_RAT", "mass": 42013.0, "length": 374, "protein_name": "C-X-C chemokine receptor type 5", "gene_name": "Cxcr5", "organism": "Rat", "refseq_name": "C-X-C chemokine receptor type 5 isoform 1", "refseq_ac": "NP_445755", "gene_names_uniprotkb": "Cxcr5; Blr1", "gene_names_refseq": "Blr1; Cxcr5; NLR", "protein_names_uniprotkb": "C-X-C chemokine receptor type 5; Burkitt lymphoma receptor 1 homolog; CXC-R5; CXCR-5; NLR; Neurolymphatic receptor", "protein_names_refseq": "C-X-C chemokine receptor type 5 isoform 1; C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; burkitt lymphoma receptor 1 homolog; chemochine (C-X-C motif) receptor 5; chemokine (C-X-C motif) receptor 5; neurolymphatic receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:29363); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "37622691;38526919;8386678", "class_list": "", "function": "CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte activation in rats by targeting NLRP3., [RefSeq, PubMed]; Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0042113 B cell activation;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P34997-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07092-1", "uniprot_id": "GDN_RAT", "mass": 44063.0, "length": 397, "protein_name": "Glia-derived nexin", "gene_name": "Serpine2", "organism": "Rat", "refseq_name": "glia-derived nexin precursor", "refseq_ac": "NP_062070", "gene_names_uniprotkb": "Serpine2; Pi7; Pn1", "gene_names_refseq": "CRG; Gdnpn1; PI-7; Pn-1; Serpine2; Spin4", "protein_names_uniprotkb": "Glia-derived nexin; GDN; PI-7; PN-1; Peptidase inhibitor 7; Protease nexin 1; Protease nexin I; Serpin E2", "protein_names_refseq": "Clozapine Regulated Gene; GDN; Glia-derived nexin/protease nexin I; glia-derived nexin / preotease nexin I; glia-derived nexin precursor; peptidase inhibitor 7; plasminogen activator inhibitor type 1; protease nexin 1; protease nexin PN-1; serine (or cysteine) peptidase inhibitor, clade E, member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease inhibitor 4; serpin E2; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serpin peptidase inhibitor, clade E, member 2", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); childhood-onset asthma (Disease Ontology:DOID:0080815); atopic dermatitis 2 (Disease Ontology:DOID:0110098); keratoconus (Disease Ontology:DOID:10126); leprosy (Disease Ontology:DOID:1024); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); ichthyosis vulgaris (Disease Ontology:DOID:1702); irritant dermatitis (Disease Ontology:DOID:2772); asthma (Disease Ontology:DOID:2841); food allergy (Disease Ontology:DOID:3044); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); allergic rhinitis (Disease Ontology:DOID:4481); brain edema (Disease Ontology:DOID:4724)", "pathway": " (rno:29366); (R-RNO-75205); (R-RNO-9769733); (R-RNO-9769739); (R-RNO-9769743)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "1554734;2337608;3427015;38843836", "class_list": "", "function": "Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0060384 innervation;GO:0010466 negative regulation of peptidase activity;GO:0008285 negative regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P07092-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70417-1", "uniprot_id": "PIP_RAT", "mass": 16439.0, "length": 146, "protein_name": "Prolactin-inducible protein homolog", "gene_name": "Pip", "organism": "Rat", "refseq_name": "prolactin-inducible protein homolog precursor", "refseq_ac": "NP_073199", "gene_names_uniprotkb": "Pip", "gene_names_refseq": "Pip", "protein_names_uniprotkb": "Prolactin-inducible protein homolog; Prolactin-induced protein", "protein_names_refseq": "prolactin-inducible protein homolog precursor; prolactin-inducible protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:64673); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21883842;9705972", "class_list": "", "function": "Pip/PIP, expressed at low levels in the genital tubercles of hypospadiac rats, may be associated with preputial development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004190 aspartic-type endopeptidase activity;GO:0019864 IgG binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0010628 positive regulation of gene expression;GO:0002682 regulation of immune system process;GO:0070233 negative regulation of T cell apoptotic process;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70417-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54316-1", "uniprot_id": "LIPR1_RAT", "mass": 52378.0, "length": 473, "protein_name": "Inactive pancreatic lipase-related protein 1", "gene_name": "Pnliprp1", "organism": "Rat", "refseq_name": "inactive pancreatic lipase-related protein 1 precursor", "refseq_ac": "NP_114470", "gene_names_uniprotkb": "Pnliprp1; Plrp1", "gene_names_refseq": "Pnliprp1", "protein_names_uniprotkb": "Inactive pancreatic lipase-related protein 1; PL-RP1", "protein_names_refseq": "PL-RP1; inactive pancreatic lipase-related protein 1 precursor; inactive pancreatic lipase-related protein 1", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:84028); (R-RNO-192456)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1730292;8203536", "class_list": "", "function": "In vitro, it has very low or undetectable lipase activity towards triglycerides (PubMed:8203536). Has negligible activity also towards diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (By similarity). Unable to hydrolyze milk fat (in vitro) (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.3;2.3.1.51;3.1.1.4;3.1.1.23;3.1.1.79;3.1.1.6;3.1.1.5;3.1.1.32;3.1.1.13;3.1.1.-;3.1.1.116;3.1.1.26;3.1.1.34", "go_molecular_function": "GO:0016298 lipase activity;GO:0005509 calcium ion binding;GO:0008970 phospholipase A1 activity;GO:0004465 lipoprotein lipase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0051384 response to glucocorticoid;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis;GO:0031016 pancreas development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P54316-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88628-1", "uniprot_id": "O51E2_RAT", "mass": 35505.0, "length": 320, "protein_name": "Olfactory receptor 51E2", "gene_name": "Olr59; Or51e2", "organism": "Rat", "refseq_name": "olfactory receptor 51E2", "refseq_ac": "NP_775415", "gene_names_uniprotkb": "Olr59; Or51e2; Olr59; Psgr", "gene_names_refseq": "Olfr78; Olr59; Or51e2; RA1c", "protein_names_uniprotkb": "Olfactory receptor 51E2; G protein-coupled receptor RA1c; Olfactory receptor 59", "protein_names_refseq": "G-protein coupled receptor RA1c; olfactory receptor 51E2; olfactory receptor 78", "tax_id": 10116, "disease": "", "pathway": " (rno:170816)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11707321;28299817;38856956;9932290", "class_list": "", "function": "Among the up-regulated hepatic genes that were identified, the expression of Olr59, Ethe1, and Slc10a2 increased specifically in rats neonatally exposed to triiodothyronine., [RefSeq, PubMed]; Expressed only in distinct regions of the brain and in addition ina defined zone of the olfactory epithelium., [RefSeq, PubMed]; Olfactory receptor. The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), cAMP and activation of phosphorylation of the protein kinases PKA and MAPK3/MAPK1. Activation of OR51E2 may affect melanocyte proliferation, differentiation, and melanogenesis and may increase proliferation and migration of primary retinal pigment epithelial (RPE) cells. Activated by the short chain fatty acids (SCFA), acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (By similarity). May also be activated by steroid hormones and regulate cell proliferation (By similarity). Activated by L-lactate in glomus cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Overexpression of olfactory receptor 78 ameliorates brain injury in cerebral ischaemia-reperfusion rats by activating Prkaca-mediated cAMP/PKA-MAPK pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0003707 nuclear steroid receptor activity;GO:0004984 olfactory receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:1900135 positive regulation of renin secretion into blood stream;GO:0097325 melanocyte proliferation;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0016477 cell migration;GO:0045777 positive regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88628-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54747-1", "uniprot_id": "DPOD1_RAT", "mass": 123601.0, "length": 1103, "protein_name": "DNA polymerase delta catalytic subunit", "gene_name": "Pold1", "organism": "Rat", "refseq_name": "DNA polymerase delta catalytic subunit", "refseq_ac": "NP_067694", "gene_names_uniprotkb": "Pold1", "gene_names_refseq": "Pold1", "protein_names_uniprotkb": "DNA polymerase delta catalytic subunit; 2.7.7.7; 3'-5' exodeoxyribonuclease; 3.1.11.-", "protein_names_refseq": "3'-5' exodeoxyribonuclease; DAN polymerase delta 1, catalytic subunit; DNA polymerase delta catalytic subunit; DNA polymerase delta, catalytic subunit; DNA-directed DNA polymerase delta 1; polymerase (DNA directed), delta 1, catalytic subunit; polymerase (DNA) delta 1, catalytic subunit", "tax_id": 10116, "disease": "immunodeficiency 120 (Disease Ontology:DOID:0061086); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:59294); (R-RNO-110314); (R-RNO-174411); (R-RNO-174414); (R-RNO-174417); (R-RNO-174437); (R-RNO-5358565); (R-RNO-5358606); (R-RNO-5651801); (R-RNO-5656169); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-69091); (R-RNO-69166); (R-RNO-69183)", "pathway_count": 19, "publication_count": 1, "publication_id_list": "9620226", "class_list": "", "function": "As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;6.5.1.1;2.3.2.32;2.7.7.7;3.1.-.-;5.2.1.8;2.4.2.-;2.7.11.1;2.7.7.102;5.6.2.4;2.7.7.6;2.7.7.49;3.6.4.12;5.6.2.1;2.7.7.31;2.7.7.-;3.1.11.-;2.3.2.27;4.2.99.18;4.2.99.-;2.4.2.30;3.1.11.2;3.1.21.-;2.7.11.22;2.7.11.23;2.7.11.24;2.3.2.23;3.4.19.12;2.3.1.48;2.3.1.-;3.6.-.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008296 3'-5'-DNA exonuclease activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000109 nucleotide-excision repair complex;GO:0043625 delta DNA polymerase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O54747-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89043-1", "uniprot_id": "DPOA2_RAT", "mass": 66636.0, "length": 600, "protein_name": "DNA polymerase alpha subunit B", "gene_name": "Pola2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pola2", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA polymerase alpha subunit B; DNA polymerase alpha 70 kDa subunit; DNA polymerase subunit II", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-113501); (R-RNO-174411); (R-RNO-174430); (R-RNO-68952); (R-RNO-68962); (R-RNO-69091); (R-RNO-69166); (R-RNO-69183)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "10541966;11536367;22673903", "class_list": "", "function": "Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYV6", "ec_number_list": "", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0006269 DNA replication, synthesis of primer;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O89043-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48807-1", "uniprot_id": "FGF5_RAT", "mass": 29264.0, "length": 266, "protein_name": "Fibroblast growth factor 5", "gene_name": "Fgf5", "organism": "Rat", "refseq_name": "fibroblast growth factor 5 isoform 1 precursor", "refseq_ac": "NP_071547", "gene_names_uniprotkb": "Fgf5; Fgf-5", "gene_names_refseq": "FGF-5; Fgf3a; Fgf5; HBGF-5", "protein_names_uniprotkb": "Fibroblast growth factor 5; FGF-5; HBGF-5; Heparin-binding growth factor 5", "protein_names_refseq": "fibroblast growth factor 3a; fibroblast growth factor 5 isoform 1 precursor; fibroblast growth factor FGF-5; heparin-binding growth factor 5", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); familial isolated trichomegaly (Disease Ontology:DOID:0111566)", "pathway": " (rno:60662); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190372); (R-RNO-190373); (R-RNO-190375); (R-RNO-5654219); (R-RNO-5654221); (R-RNO-5654227); (R-RNO-5654687); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5658623); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 25, "publication_count": 1, "publication_id_list": "8611621", "class_list": "", "function": "Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63402", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051781 positive regulation of cell division;GO:0030334 regulation of cell migration;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P48807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18901-1", "uniprot_id": "DRD1_RAT", "mass": 49428.0, "length": 446, "protein_name": "D(1A) dopamine receptor", "gene_name": "Drd1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Drd1; Drd1a", "gene_names_refseq": "", "protein_names_uniprotkb": "D(1A) dopamine receptor; Dopamine D1 receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); traumatic brain injury (Disease Ontology:DOID:0081292); bacterial infectious disease (Disease Ontology:DOID:104); Fanconi syndrome (Disease Ontology:DOID:1062); cystinosis (Disease Ontology:DOID:1064); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); tracheal stenosis (Disease Ontology:DOID:3227); hyperglycemia (Disease Ontology:DOID:4195); ureteral obstruction (Disease Ontology:DOID:5199); end stage renal disease (Disease Ontology:DOID:783); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24316)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11331877;1402930;2138567;2168520;2168556", "class_list": "", "function": "Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Forms heterotetramers with DRD3 to potentiate beta-arrestin recruitment and mediate locomotor activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P21669", "ec_number_list": "", "go_molecular_function": "GO:0004952 dopamine neurotransmitter receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0051117 ATPase binding;GO:0004993 G protein-coupled serotonin receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0030432 peristalsis;GO:0046959 habituation;GO:0042321 negative regulation of circadian sleep/wake cycle, sleep;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0035106 operant conditioning", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18901-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15800-1", "uniprot_id": "LAMB2_RAT", "mass": 196474.0, "length": 1801, "protein_name": "Laminin subunit beta-2", "gene_name": "Lamb2", "organism": "Rat", "refseq_name": "laminin subunit beta-2 precursor", "refseq_ac": "NP_037106", "gene_names_uniprotkb": "Lamb2", "gene_names_refseq": "Lamb2; SLAM", "protein_names_uniprotkb": "Laminin subunit beta-2; Laminin chain B3; Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-LAM beta; S-laminin subunit beta", "protein_names_refseq": "S-LAM beta; S-laminin subunit beta; laminin chain B3; laminin chain beta 2; laminin subunit beta-2 precursor; laminin, beta 2; laminin-11 subunit beta; laminin-14 subunit beta; laminin-15 subunit beta; laminin-3 subunit beta; laminin-4 subunit beta; laminin-7 subunit beta; laminin-9 subunit beta", "tax_id": 10116, "disease": "Pierson syndrome (Disease Ontology:DOID:0060852); nephrotic syndrome type 5 (Disease Ontology:DOID:0080380); immunodeficiency 40 (Disease Ontology:DOID:0111951); primary open angle glaucoma (Disease Ontology:DOID:1070); nephrosis (Disease Ontology:DOID:2527); proteinuria (Disease Ontology:DOID:576)", "pathway": " (rno:25473)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24090084;27425256;2922051", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB, UniProtKB, UniProtKB]; Crystallographic analysis of the LAMB2 short arm reveals how the LF domain is inserted into a regular array of LE domains., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 6, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0150043 structural constituent of synapse-associated extracellular matrix", "go_cellular_component": "GO:0031594 neuromuscular junction;GO:0045202 synapse;GO:0043083 synaptic cleft;GO:0005604 basement membrane;GO:0043256 laminin complex", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0016477 cell migration;GO:0031175 neuron projection development;GO:0050808 synapse organization;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P15800-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08957-1", "uniprot_id": "NRN1_RAT", "mass": 15289.0, "length": 142, "protein_name": "Neuritin", "gene_name": "Nrn1", "organism": "Rat", "refseq_name": "neuritin precursor", "refseq_ac": "NP_445798", "gene_names_uniprotkb": "Nrn1", "gene_names_refseq": "Nrn1; Nrn", "protein_names_uniprotkb": "Neuritin", "protein_names_refseq": "neuritin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:83834); (R-RNO-163125)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17909094;22177131;22632720;28852892;28871047;32607759;33323541;39187917;9122250", "class_list": "", "function": "Manipulation of neuritin levels in diabetes may provide a potential target for therapeutic intervention in the management of neuropathy., [RefSeq, PubMed]; Neuritin accelerates Schwann cell dedifferentiation via PI3K/Akt/mTOR signalling pathway during Wallerian degeneration., [RefSeq, PubMed]; Neuritin-overexpressing transgenic mice demonstrate enhanced neuroregeneration capacity and improved spatial learning and memory recovery after ischemia-reperfusion injury., [RefSeq, PubMed]; Nrn1 Overexpression Attenuates Retinal Ganglion Cell Apoptosis, Promotes Axonal Regeneration, and Improves Visual Function Following Optic Nerve Crush in Rats., [RefSeq, PubMed]; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells., [UniProtKB, PubMed]; Recombinant neuritin affects the senescence, apoptosis, proliferation, migration of rat bone marrow-derived mesenchymal stem cells. These findings offer new insight into neuritin function outside of the nervous system., [RefSeq, PubMed]; The data indicate that endogenous Nrn1 and Gap43 mRNAs compete for binding to HuD for their axonal localization and activity of the Nrn1 3'UTR., [RefSeq, PubMed]; The expression of Neuritin protein in the visual cortex of rats in the monocular deprived group was considerably lower than that of the normal control group., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0032281 AMPA glutamate receptor complex;GO:0098793 presynapse", "go_biological_process": "GO:0007399 nervous system development;GO:1990138 neuron projection extension;GO:0090128 regulation of synapse maturation;GO:0099171 presynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O08957-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10937-1", "uniprot_id": "PNMT_RAT", "mass": 31670.0, "length": 285, "protein_name": "Phenylethanolamine N-methyltransferase", "gene_name": "Pnmt", "organism": "Rat", "refseq_name": "phenylethanolamine N-methyltransferase", "refseq_ac": "NP_113714", "gene_names_uniprotkb": "Pnmt", "gene_names_refseq": "Pnmt", "protein_names_uniprotkb": "Phenylethanolamine N-methyltransferase; 2.1.1.28; Noradrenaline N-methyltransferase; PNMTase", "protein_names_refseq": "PNMTase; noradrenaline N-methyltransferase; phenylethanolamine N-methyltransferase", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); multiple sclerosis (Disease Ontology:DOID:2377); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:24661); (R-RNO-209905)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "13863458;21777029;22007271;2575695;26475702;2928117;683413;7558218;7931317", "class_list": "", "function": "Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (By similarity). Other substrates include phenylethanolamine, octopamine and normetanephrine (PubMed:13863458, PubMed:683413)., [UniProtKB, PubMed, UniProtKB, PubMed]; Findings demonstrate that CoCl(2)-induced ROS have synergistic effects on hormonal and neural activation of the PNMT promoter., [RefSeq, PubMed]; Stress elevated PNMT levels in heart ventricles., [RefSeq, PubMed]; These results suggest that increased PNMT gene expression via altered transcriptional activity is a possible mechanism by which prenatal exposure to elevated levels of glucocorticoids may program for hypertension later in life., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.28", "go_molecular_function": "GO:0016740 transferase activity;GO:0008168 methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0004603 phenylethanolamine N-methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043195 terminal bouton", "go_biological_process": "GO:0035900 response to isolation stress;GO:0045471 response to ethanol;GO:0001666 response to hypoxia;GO:0071363 cellular response to growth factor stimulus;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P10937-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0RD54-1", "uniprot_id": "CEFIP_RAT", "mass": 155409.0, "length": 1422, "protein_name": "Cardiac-enriched FHL2-interacting protein", "gene_name": "CEFIP", "organism": "Rat", "refseq_name": "cardiac-enriched FHL2-interacting protein isoform X1", "refseq_ac": "XP_006252819", "gene_names_uniprotkb": "CEFIP", "gene_names_refseq": "C16h10orf71; CEFIP; RGD1564899", "protein_names_uniprotkb": "Cardiac-enriched FHL2-interacting protein", "protein_names_refseq": "cardiac-enriched FHL2-interacting protein isoform X1", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "28717008", "class_list": "", "function": "Is an activator of the calcineurin/NFAT signaling pathway in cardiomyocytes, and is involved in myocardium morphogenesis, and regulation of myocardium mass and cardiac contractile function., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030018 Z disc", "go_biological_process": "GO:0070886 positive regulation of calcineurin-NFAT signaling cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0RD54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08565-1", "uniprot_id": "CXCR4_RAT", "mass": 39429.0, "length": 349, "protein_name": "C-X-C chemokine receptor type 4", "gene_name": "Cxcr4", "organism": "Rat", "refseq_name": "C-X-C chemokine receptor type 4", "refseq_ac": "NP_071541", "gene_names_uniprotkb": "Cxcr4; Cmkar4", "gene_names_refseq": "Cxcr4", "protein_names_uniprotkb": "C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Fusin; LESTR; Leukocyte-derived seven transmembrane domain receptor; SDF-1 receptor; Stromal cell-derived factor 1 receptor", "protein_names_refseq": "C-X-C chemokine receptor type 4; CXC chemokine receptor; CXC-R4; CXCR-4; LESTR; SDF-1 receptor; chemokine (C-X-C motif) receptor 4; chemokine receptor (LCR1); fusin; leukocyte-derived seven transmembrane domain receptor; stromal cell-derived factor 1 receptor", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Disease Ontology:DOID:0050909); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); WHIM syndrome 1 (Disease Ontology:DOID:0060591); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); osteoporosis (Disease Ontology:DOID:11476); rectum cancer (Disease Ontology:DOID:1993); larynx cancer (Disease Ontology:DOID:2596); laryngeal carcinoma (Disease Ontology:DOID:2600); temporal lobe epilepsy (Disease Ontology:DOID:3328); osteosarcoma (Disease Ontology:DOID:3347); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); hemangioblastoma (Disease Ontology:DOID:5241); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); congestive heart failure (Disease Ontology:DOID:6000); leukopenia (Disease Ontology:DOID:615); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); ulcerative colitis (Disease Ontology:DOID:8577); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:60628); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "35799894;36193608;37497691;37614198;38566371", "class_list": "", "function": "CXCR4/CX43 Regulate Diabetic Neuropathic Pain via Intercellular Interactions between Activated Neurons and Dysfunctional Astrocytes during Late Phase of Diabetes in Rats and the Effects of Antioxidant N-Acetyl-L-Cysteine. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-9a-5p alleviates ventilator-induced lung injury in rats by inhibiting the activation of the MAPK signaling pathway via CXCR4 expression downregulation., [RefSeq, PubMed]; Overexpression of HSP27 accelerates stress-induced gastric ulcer healing via the CXCL12/CXCR4 axis., [RefSeq, PubMed]; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CXCR4 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development; in the CNS, could mediate hippocampal-neuron surviva (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Stromal cell-derived factor-1 downregulation contributes to neuroprotection mediated by CXC chemokine receptor 4 interactions after intracerebral hemorrhage in rats., [RefSeq, PubMed]; The CXCL12-CXCR4-NLRP3 axis promotes Schwann cell pyroptosis and sciatic nerve demyelination in rats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1LPN8;Q8VD47", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface", "go_biological_process": "GO:0050792 regulation of viral process;GO:0030316 osteoclast differentiation;GO:1903861 positive regulation of dendrite extension;GO:0035470 positive regulation of vascular wound healing;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08565-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35112-1", "uniprot_id": "CD166_RAT", "mass": 65022.0, "length": 583, "protein_name": "CD166 antigen", "gene_name": "Alcam", "organism": "Rat", "refseq_name": "CD166 antigen isoform 2 precursor", "refseq_ac": "NP_113941", "gene_names_uniprotkb": "Alcam", "gene_names_refseq": "Alcam", "protein_names_uniprotkb": "CD166 antigen; Activated leukocyte cell adhesion molecule; HB2; KG-CAM; Protein MEMD; SB-10 antigen", "protein_names_refseq": "CD166 antigen isoform 2 precursor; CD166 antigen; HB2; KG-CAM; SB-10 antigen", "tax_id": 10116, "disease": "", "pathway": " (rno:79559)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1039/D0MO00044B;22243278;24090084;28720382;34106099;38717494;38843836;8004458;9201982;9556065", "class_list": "", "function": "ALCAM synergizes with nerve growth factor to induce neuronal differentiation, raising the possibility that it functions not only as an adhesion molecule but also in the modulation of growth factor signaling in the nervous system, [RefSeq, PubMed]; Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity). Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiRNA-192-5p-targeted activated leukocyte cell adhesion molecule improved inflammatory injury of neonatal necrotizing enterocolitis. Publication Status: Online-Only, [RefSeq, PubMed]; The modulatory roles of ALCAM in the excitatory synaptic transmission and plasticity in the rat spinal dorsal horn, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "O55172", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0042101 T cell receptor complex;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007155 cell adhesion;GO:0031175 neuron projection development;GO:0002250 adaptive immune response;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O35112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35264-1", "uniprot_id": "PA1B2_RAT", "mass": 25581.0, "length": 229, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit alpha2", "gene_name": "Pafah1b2", "organism": "Rat", "refseq_name": "platelet-activating factor acetylhydrolase IB subunit alpha2", "refseq_ac": "NP_071782", "gene_names_uniprotkb": "Pafah1b2; Pafahb", "gene_names_refseq": "Pafah1b2", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit alpha2; 3.1.1.47; PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH alpha 2; PAF-AH subunit beta; PAFAH subunit beta; Platelet-activating factor acetylhydrolase alpha 2 subunit", "protein_names_refseq": "PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH alpha 2; PAF-AH subunit beta; PAFAH subunit beta; platelet-activating factor acetylhydrolase IB subunit alpha2; platelet-activating factor acetylhydrolase IB subunit beta; platelet-activating factor acetylhydrolase alpha 2 subunit (PAF-AH alpha 2)", "tax_id": 10116, "disease": "lymphoma (Disease Ontology:DOID:0060058); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (rno:64189); (R-RNO-6798695); (R-RNO-6811436)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15456758;22673903;33760887;9459487;9660828", "class_list": "", "function": "Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF (PubMed:9660828). The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MicroRNA-212-5p and its target PAFAH1B2 suppress vascular proliferation and contraction via the downregulation of RhoA. Publication Status: Online-Only, [RefSeq, PubMed]; The PAF receptor-independent death pathway is regulated by PAF-AH I alpha2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.47;5.2.1.8;1.1.1.205;3.2.1.23;3.1.1.32;3.1.1.4;3.5.4.5;2.3.2.5;3.6.4.13;2.4.1.25;3.2.1.33;4.2.99.18;5.6.2.4;4.1.2.4;2.4.1.186;3.5.4.6;2.7.1.35;3.5.1.1;3.1.1.5;3.4.22.1;1.11.1.6;2.5.1.18;4.1.2.13;3.6.5.-;4.2.1.24;3.2.1.31;2.4.1.1;2.7.10.2;2.7.11.1;2.7.1.40;1.13.11.-;1.13.11.34;3.4.19.1;2.3.3.8;2.3.1.43;1.16.3.1;2.7.4.6;2.7.13.3;3.4.23.5;5.4.2.11;5.4.2.4;2.7.1.1;3.3.2.6;3.4.11.4;2.7.1.11;5.3.2.1;5.3.3.12;3.4.21.46;3.1.6.4;2.4.2.7;5.4.2.2;1.1.1.42;3.6.4.6;3.4.24.35;3.1.6.12;2.3.2.26;3.6.4.10;2.7.11.24;2.3.1.149;2.4.2.1;3.1.2.2;3.4.22.52;3.4.22.27;2.7.11.39;5.3.1.9;5.1.3.-;3.5.1.23;3.5.1.-;3.6.1.6;3.4.25.1;3.4.18.1;1.11.1.24", "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0016042 lipid catabolic process;GO:0016239 positive regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35264-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35276-1", "uniprot_id": "NRP2_RAT", "mass": 103897.0, "length": 925, "protein_name": "Neuropilin-2", "gene_name": "Nrp2", "organism": "Rat", "refseq_name": "neuropilin-2 precursor", "refseq_ac": "NP_110496", "gene_names_uniprotkb": "Nrp2", "gene_names_refseq": "Nrp2", "protein_names_uniprotkb": "Neuropilin-2; Vascular endothelial cell growth factor 165 receptor 2", "protein_names_refseq": "neuropilin-2 precursor; vascular endothelial cell growth factor 165 receptor 2", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:81527); (R-RNO-194306)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11906695;12426047;26410366;28270793;31211440;36044155;38843836;9288754", "class_list": "", "function": "High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Important role in the regulation of neointimal hyperplasia by modulating vascular smooth muscle cell migration and proliferation, [RefSeq, PubMed]; Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy., [RefSeq, PubMed]; Neuropilin-2 is overexpressed in the rat brain after limbic seizures, [RefSeq, PubMed]; Npn-2 and candidate pheromone receptors play distinct and complementary roles in promoting the wiring and patterning of sensory neurons in the accessory olfactory system., [RefSeq, PubMed]; VEGF-C/NRP-2 may mediate autophagy by regulating the phosphorylation of 4EBP1 and P70S6K; VEGF-C treatment may be identified as a therapeutic target in renal injury repair due to its capacity to promote tubular cell survival in the future, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0017154 semaphorin receptor activity;GO:0005021 vascular endothelial growth factor receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0045211 postsynaptic membrane;GO:0016020 membrane", "go_biological_process": "GO:0097490 sympathetic neuron projection extension;GO:0097491 sympathetic neuron projection guidance;GO:0001525 angiogenesis;GO:0007507 heart development;GO:0071526 semaphorin-plexin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35276-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35293-1", "uniprot_id": "CP2F2_RAT", "mass": 55946.0, "length": 491, "protein_name": "Cytochrome P450 2F2", "gene_name": "Cyp2f2", "organism": "Rat", "refseq_name": "cytochrome P450 2F2", "refseq_ac": "NP_062176", "gene_names_uniprotkb": "Cyp2f2; Cyp2f4", "gene_names_refseq": "CYP4502F4; Cyp2f1; Cyp2f2; Cyp2f4", "protein_names_uniprotkb": "Cytochrome P450 2F2; 1.14.14.-; CYPIIF2; Cytochrome P450-NAH-2; Naphthalene dehydrogenase; Naphthalene hydroxylase", "protein_names_refseq": "CYPIIF2; Cytochrome P450, subfamily IIF, polypeptide 1; P450-NAH-2; cytochrome P450 2F2; cytochrome P450, family 2, subfamily f, polypeptide 2; cytochrome P450, subfamily 2F, polypeptide 1; cytochrome P450-NAH-2; naphthalene dehydrogenase; naphthalene hydroxylase", "tax_id": 10116, "disease": "", "pathway": " (rno:54246); (R-RNO-211935); (R-RNO-211981); (R-RNO-211999)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15509722", "class_list": "", "function": "Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or club cells in lung., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0009636 response to toxic substance;GO:0019373 epoxygenase P450 pathway;GO:0018979 trichloroethylene metabolic process;GO:1901170 naphthalene catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35293-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35312-1", "uniprot_id": "GDF8_RAT", "mass": 42829.0, "length": 376, "protein_name": "Growth/differentiation factor 8", "gene_name": "Mstn", "organism": "Rat", "refseq_name": "growth/differentiation factor 8 precursor", "refseq_ac": "NP_062024", "gene_names_uniprotkb": "Mstn; Gdf8", "gene_names_refseq": "Gdf8; Mstn", "protein_names_uniprotkb": "Growth/differentiation factor 8; GDF-8; Myostatin", "protein_names_refseq": "GDF-8; growth/differentiation factor 8 precursor; growth/differentiation factor 8", "tax_id": 10116, "disease": "vertebral hypersegmentation and orofacial anomalies (Disease Ontology:DOID:0070418); myostatin-related muscle hypertrophy (Disease Ontology:DOID:0111072); prostate cancer (Disease Ontology:DOID:10283); hypothyroidism (Disease Ontology:DOID:1459); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); peripheral vascular disease (Disease Ontology:DOID:341); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); uremia (Disease Ontology:DOID:4676); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:29152)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "34453705;34576046;35758824;39093510;9356471", "class_list": "", "function": "Acts specifically as a negative regulator of skeletal muscle growth., [UniProtKB, UniProtKB]; Enhanced Myogenesis by Silencing Myostatin with Nonviral Delivery of a dCas9 Ribonucleoprotein Complex., [RefSeq, PubMed]; MSTN is an important myokine for weight-bearing training to attenuate bone loss in ovariectomized rats., [RefSeq, PubMed]; Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Swimming in cold water increases the browning process by diminishing the Myostatin pathway. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the TGF-beta (transforming growth factor-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate an N-terminal propeptide and a C-terminal subunit. The C-terminal subunits form the mature homodimer, which negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jun 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0014816 skeletal muscle satellite cell differentiation;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0045471 response to ethanol;GO:0046716 muscle cell cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35312-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35790-1", "uniprot_id": "PIGL_RAT", "mass": 27984.0, "length": 252, "protein_name": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase", "gene_name": "Pigl", "organism": "Rat", "refseq_name": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase", "refseq_ac": "NP_620256", "gene_names_uniprotkb": "Pigl", "gene_names_refseq": "Pigl", "protein_names_uniprotkb": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; 3.5.1.89; PIG-L; Phosphatidylinositol-glycan biosynthesis class L protein", "protein_names_refseq": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; PIG-L; phosphatidylinositol glycan, class L; phosphatidylinositol-glycan biosynthesis class L protein", "tax_id": 10116, "disease": "CHIME syndrome (Disease Ontology:DOID:0112152)", "pathway": " (rno:192263); (R-RNO-162710)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10085243;15817455;29393594;9188481", "class_list": "", "function": "Catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol., [UniProtKB, PubMed, PubMed]; N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.89", "go_molecular_function": "GO:0000225 N-acetylglucosaminylphosphatidylinositol deacetylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35790-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54842-1", "uniprot_id": "NUPR1_RAT", "mass": 8955.0, "length": 80, "protein_name": "Nuclear protein 1", "gene_name": "Nupr1", "organism": "Rat", "refseq_name": "nuclear protein 1", "refseq_ac": "NP_446063", "gene_names_uniprotkb": "Nupr1", "gene_names_refseq": "Nupr1l1; Nupr1; p8", "protein_names_uniprotkb": "Nuclear protein 1; Protein p8", "protein_names_refseq": "candidate of metastasis 1; nuclear protein 1-like; nuclear protein 1; nuclear protein, transcriptional regulator, 1-like 1; nuclear protein, transcriptional regulator, 1; nuclear proten 1; nuclear transcriptional regulator protein 1; protein p8", "tax_id": 10116, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457)", "pathway": " (rno:100912108)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20181828;27031958;27451286;28694771;31914690;34830471;9405444", "class_list": "", "function": "Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers. Publication Status: Online-Only, [RefSeq, PubMed]; Nupr1 silencing also reduced CSMC apoptosis., [RefSeq, PubMed]; Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:20181828, PubMed:27031958, PubMed:28694771). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (By similarity). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (By similarity). Negatively regulates apoptosis through interaction with PTMA (By similarity). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (PubMed:27031958, PubMed:28694771). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (By similarity). Coactivator of PAX2 transcription factor activity, both by recruiting the EP300 cofactor to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (By similarity). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (By similarity). Coordinates, through its interaction with EP300, the association of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (By similarity). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0032993 protein-DNA complex", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:1904036 negative regulation of epithelial cell apoptotic process;GO:1904691 negative regulation of type B pancreatic cell proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0010506 regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O54842-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54857-1", "uniprot_id": "PTEN_RAT", "mass": 47118.0, "length": 403, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN", "gene_name": "Pten", "organism": "Rat", "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN", "refseq_ac": "NP_113794", "gene_names_uniprotkb": "Pten; rCG_47874", "gene_names_refseq": "MMAC1; Mmac; Pten; TEP1", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; 3.1.3.-; 3.1.3.16; 3.1.3.48; 3.1.3.67; Inositol polyphosphate 3-phosphatase; Phosphatase and tensin homolog", "protein_names_refseq": "inositol polyphosphate 3-phosphatase; mutated in multiple advanced cancers 1; phosphatase and tensin homolog deleted on chromosome ten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); Cowden syndrome 1 (Disease Ontology:DOID:0050657); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); ovarian serous carcinoma (Disease Ontology:DOID:0050933); autism spectrum disorder (Disease Ontology:DOID:0060041); cerebral cavernous malformation (Disease Ontology:DOID:0060669); macrocephaly-autism syndrome (Disease Ontology:DOID:0060867); intestinal pseudo-obstruction (Disease Ontology:DOID:0080072); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); retinitis pigmentosa (Disease Ontology:DOID:10584); portal hypertension (Disease Ontology:DOID:10762); urinary bladder cancer (Disease Ontology:DOID:11054); peripheral nervous system neoplasm (Disease Ontology:DOID:1192); leiomyoma (Disease Ontology:DOID:127); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); biliary atresia (Disease Ontology:DOID:13608); endometrial cancer (Disease Ontology:DOID:1380); major depressive disorder (Disease Ontology:DOID:1470); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); hyperinsulinism (Disease Ontology:DOID:2018); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); hemangiopericytoma (Disease Ontology:DOID:264); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); substance-related disorder (Disease Ontology:DOID:303); high grade glioma (Disease Ontology:DOID:3070); angiomyolipoma (Disease Ontology:DOID:3314); bladder squamous cell carcinoma (Disease Ontology:DOID:3742); lung non-small cell carcinoma (Disease Ontology:DOID:3908); follicular thyroid carcinoma (Disease Ontology:DOID:3962); renal cell carcinoma (Disease Ontology:DOID:4450); familial meningioma (Disease Ontology:DOID:4586); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); esophageal cancer (Disease Ontology:DOID:5041); Cowden syndrome (Disease Ontology:DOID:6457); hepatocellular carcinoma (Disease Ontology:DOID:684); stomach disease (Disease Ontology:DOID:76); sporadic breast cancer (Disease Ontology:DOID:8029); in situ carcinoma (Disease Ontology:DOID:8719); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); brain disease (Disease Ontology:DOID:936); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:50557); (R-RNO-1660499); (R-RNO-1855204); (R-RNO-199418); (R-RNO-202424); (R-RNO-5689880); (R-RNO-5689896); (R-RNO-8948747); (R-RNO-8948751)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "12461751;20628354;22673903;37393018;37589761;38092760;38279488;38508437", "class_list": "", "function": "Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPalpha signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3. Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (By similarity). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (By similarity). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (Ref.7). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibiting autophagy by miR-19a-3p/PTEN regulation protected retinal pigment epithelial cells from hyperglycemic damage., [RefSeq, PubMed]; N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats. Publication Status: Online-Only, [RefSeq, PubMed]; Oxidized DJ-1 activates the p-IKK/NF-kappaB/Beclin1 pathway by binding PTEN to induce autophagy and exacerbate myocardial ischemia-reperfusion injury., [RefSeq, PubMed]; Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling Events., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 52, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.-;3.1.3.48;3.1.3.16;2.7.10.1;2.3.2.27;3.1.3.62;3.1.3.80;3.1.3.53;3.1.3.2;3.1.3.52;2.3.2.26;3.4.19.12;3.1.3.21;3.1.3.18;2.7.11.1;3.1.3.67;3.1.3.-;3.1.3.86;3.1.3.95;3.1.3.36;3.1.3.27;3.1.3.5;3.4.25.1;2.7.11.22;2.7.10.2;3.1.3.74", "go_molecular_function": "GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity;GO:0005161 platelet-derived growth factor receptor binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1903690 negative regulation of wound healing, spreading of epidermal cells;GO:0060024 rhythmic synaptic transmission;GO:0032535 regulation of cellular component size;GO:0033032 regulation of myeloid cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54857-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70249-1", "uniprot_id": "OGG1_RAT", "mass": 38711.0, "length": 345, "protein_name": "N-glycosylase/DNA lyase", "gene_name": "Ogg1", "organism": "Rat", "refseq_name": "N-glycosylase/DNA lyase", "refseq_ac": "NP_110497", "gene_names_uniprotkb": "Ogg1; Mmh; Ogh1", "gene_names_refseq": "Ogg1", "protein_names_uniprotkb": "N-glycosylase/DNA lyase", "protein_names_refseq": "8-oxoguanine DNA-glycosylase 1; N-glycosylase/DNA lyase", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); Graves' disease (Disease Ontology:DOID:12361); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); hepatitis (Disease Ontology:DOID:2237); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); basal cell carcinoma (Disease Ontology:DOID:2513); transitional cell carcinoma (Disease Ontology:DOID:2671); angiomyolipoma (Disease Ontology:DOID:3314); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); progressive supranuclear palsy (Disease Ontology:DOID:678); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (rno:81528); (R-RNO-110329); (R-RNO-110330); (R-RNO-110331); (R-RNO-110357); (R-RNO-5649702)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "27091693;28758699;28882450;33471970;9801319", "class_list": "", "function": "Chronic hypobaric hypoxia attenuates OGG1 expression in rat spermatozoa in a time-dependent fashion, with a greater reduction in the mitochondrial isoform OGG1-2a., [RefSeq, PubMed]; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion., [UniProtKB, UniProtKB, UniProtKB]; Ogg1 overexpression also reduced binding of mitochondrial transcription factor A (TFAM) to both regulatory and coding regions of the mitochondrial genome without altering total abundance of TFAM in either control or hypoxic cells. These observations suggest that oxidative DNA modifications in the D-loop region during hypoxia are important for increased TFAM binding and ensuing replication of the mitochondrial genome., [RefSeq, PubMed]; The effects of voluntary complex and regular wheel running exercises on the levels of 8-oxoguanine DNA glycosylase, semaphorin 3B, H2O2, and apoptosis in the hippocampus of diabetic rats., [RefSeq, PubMed]; The increase in the oxidative stress in compensated cardiac hypertrophy induced the OGG1-2a migration to mitochondria to repair mtDNA oxidation, as a mechanism that allows maintaining the cardiac function in the compensatory stage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.51;4.2.99.18;1.14.11.33;3.2.2.-;5.6.2.4;2.7.7.7;4.2.99.-", "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity;GO:0003677 DNA binding;GO:0008017 microtubule binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0016607 nuclear speck;GO:0016363 nuclear matrix", "go_biological_process": "GO:1901291 negative regulation of double-strand break repair via single-strand annealing;GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O70249-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70610-1", "uniprot_id": "CXD2_RAT", "mass": 36052.0, "length": 321, "protein_name": "Gap junction delta-2 protein", "gene_name": "Gjd2", "organism": "Rat", "refseq_name": "gap junction delta-2 protein", "refseq_ac": "NP_062154", "gene_names_uniprotkb": "Gjd2; Gja9", "gene_names_refseq": "Cx36; Cxns; Gja9; Gjd2", "protein_names_uniprotkb": "Gap junction delta-2 protein; Connexin-36; Cx36; Gap junction alpha-9 protein", "protein_names_refseq": "connexin s; connexin-36; gap junction alpha-9 protein; gap junction delta-2 protein; gap junction membrane channel protein alpha 9", "tax_id": 10116, "disease": "", "pathway": " (rno:50564); (R-RNO-112303); (R-RNO-190861)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12064624;12766175;29746991;30016355;31091986;31557934;36471528;9645468", "class_list": "", "function": "Connexin-36 contributes to control function of insulin-producing cells., [RefSeq, PubMed]; Cx36-mediated junctional communication plays a crucial role in autoregulatory control of oxytocin neuronal activity, [RefSeq, PubMed]; Data provide evidence that connexin 36-dependent signaling contributes to regulate the function of native and tumoral insulin-producing cells, [RefSeq, PubMed]; Expression of the gap junction protein connexin36 in small intensely fluorescent (SIF) cells in cardiac parasympathetic ganglia of rodents., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]; Our findings demonstrated that Cx36 play an important role in mechanical allodynia by coupling GABA cells, [RefSeq, PubMed]; These results suggest that leonurine might have a protective effect on OGD-induced PC12 cells through targeting the Cx36/CaMKII pathway. Thus, leonurine appears to have potential as a preventive or therapeutic drug against ischemic-induced neuronal injury. Publication Status: Online-Only, [RefSeq, PubMed]; Tubulin-dependent transport of Cx36 potentiates synaptic strength by delivering channels to Gap-junction plaques, reinforcing the role of protein transport at chemical and electrical synapses to fine-tune communication between neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ER25", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0045202 synapse;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0001508 action potential;GO:0007268 chemical synaptic transmission;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O70610-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88178-1", "uniprot_id": "B3GT4_RAT", "mass": 41254.0, "length": 371, "protein_name": "Beta-1,3-galactosyltransferase 4", "gene_name": "B3galt4; Rps18", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "B3galt4; Rps18; B3galt4", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-1,3-galactosyltransferase 4; 2.4.1.62; Beta-1,3-GalTase 4; Beta3Gal-T4; Beta3GalT4; Gal-T2; Ganglioside galactosyltransferase; UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase; b3Gal-T4", "protein_names_refseq": "", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); facioscapulohumeral muscular dystrophy (Disease Ontology:DOID:11727); nephrotic syndrome (Disease Ontology:DOID:1184); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-9037629); (R-RNO-9840309)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9312075", "class_list": "glycogene;glycosyltransferase", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]; Involved in GM1/GD1B/GA1 ganglioside biosynthesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.62", "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity;GO:0047915 ganglioside galactosyltransferase activity;GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0001574 ganglioside biosynthetic process;GO:0006412 translation", "synthesized_glycan_count": 300, "hit_score": 0.2, "record_id": "O88178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88807-1", "uniprot_id": "PADI4_RAT", "mass": 74467.0, "length": 666, "protein_name": "Protein-arginine deiminase type-4", "gene_name": "Padi4", "organism": "Rat", "refseq_name": "protein-arginine deiminase type-4", "refseq_ac": "NP_058923", "gene_names_uniprotkb": "Padi4; Pad4; Pdi4", "gene_names_refseq": "Padi4; Pdi4", "protein_names_uniprotkb": "Protein-arginine deiminase type-4; 3.5.3.15; PAD-R4; Peptidylarginine deiminase IV; Peptidylarginine deiminase type alpha; Protein-arginine deiminase type IV", "protein_names_refseq": "PAD-R4; peptidyl arginine deiminase, type 4; peptidyl arginine deiminase, type IV; peptidylarginine deiminase IV; peptidylarginine deiminase type alpha; protein-arginine deiminase type IV; protein-arginine deiminase type-4", "tax_id": 10116, "disease": "", "pathway": " (rno:29512); (R-RNO-3247509)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "9675292;9738944", "class_list": "", "function": "Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Involved for the formation of neutrophil extracellular traps (NETs) by mediating citrullination of histone H3 and initiating decondensation of chromatin and nuclear membrane rupture. NETs are mainly composed of DNA fibers and are released by neutrophils to trap pathogens during inflammation. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1., [UniProtKB, UniProtKB]; Catalyzes the deimination of arginine residues of proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35117", "ec_number_list": "3.5.3.15", "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0140794 histone arginine deiminase activity;GO:0140795 histone H3R2 arginine deiminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0043687 post-translational protein modification;GO:0045087 innate immune response;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00173-1", "uniprot_id": "CYB5_RAT", "mass": 15355.0, "length": 134, "protein_name": "Cytochrome b5", "gene_name": "Cyb5a", "organism": "Rat", "refseq_name": "cytochrome b5", "refseq_ac": "NP_071581", "gene_names_uniprotkb": "Cyb5a; Cyb5", "gene_names_refseq": "Cyb5a; Cyb5", "protein_names_uniprotkb": "Cytochrome b5", "protein_names_refseq": "cytochrome b-5; cytochrome b5 type A (microsomal); cytochrome b5", "tax_id": 10116, "disease": "methemoglobinemia and ambiguous genitalia (Disease Ontology:DOID:0112316); methemoglobinemia (Disease Ontology:DOID:10783); pyelonephritis (Disease Ontology:DOID:11400); stomatitis (Disease Ontology:DOID:9637)", "pathway": " (rno:64001); (R-RNO-196836); (R-RNO-9609523)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11294656;1396600;20511233;2752049;29227865;6840088;7093287;8639599;9245704;9363779;9425037;9622481", "class_list": "", "function": "Cygb has a nitric-oxide dioxygenase function and ascorbate and cytochrome b(5) have roles as reductants, [RefSeq, PubMed]; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. It is also involved in several steps of the sterol biosynthesis pathway, particularly in the C-6 double bond introduction during the C-6 desaturation., [UniProtKB]; Superoxide anion production and cytochrome c reduction are the consequences of the stimulated NADH consumption by cytochrome b5 reductase upon complex formation with cytochrome c and suggest a major role of this enzyme as an anti-apoptotic protein during cell death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35768", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046686 response to cadmium ion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P00173-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00481-1", "uniprot_id": "OTC_RAT", "mass": 39886.0, "length": 354, "protein_name": "Ornithine transcarbamylase, mitochondrial", "gene_name": "Otc", "organism": "Rat", "refseq_name": "ornithine transcarbamylase, mitochondrial precursor", "refseq_ac": "NP_037210", "gene_names_uniprotkb": "Otc", "gene_names_refseq": "Otc", "protein_names_uniprotkb": "Ornithine transcarbamylase, mitochondrial; 2.1.3.3; OTCase; Ornithine carbamoyltransferase, mitochondrial", "protein_names_refseq": "OTCase; ornithine carbamoyltransferase, mitochondrial; ornithine transcarbamylase, mitochondrial precursor; ornithine transcarbamylase, mitochondrial", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); nicotine dependence (Disease Ontology:DOID:0050742); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); neonatal nephrocutaneous inflammatory syndrome (Disease Ontology:DOID:0061191); alcohol-associated liver disease (Disease Ontology:DOID:0070658); Coronavirus infectious disease (Disease Ontology:DOID:0080599); Parkinsonism (Disease Ontology:DOID:0080855); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); dilated cardiomyopathy (Disease Ontology:DOID:12930); dementia (Disease Ontology:DOID:1307); lung cancer (Disease Ontology:DOID:1324); cholestasis (Disease Ontology:DOID:13580); peptic esophagitis (Disease Ontology:DOID:13976); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); median neuropathy (Disease Ontology:DOID:571); aortic valve disease (Disease Ontology:DOID:62); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); lung disease (Disease Ontology:DOID:850); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); ornithine carbamoyltransferase deficiency (Disease Ontology:DOID:9271); diabetes mellitus (Disease Ontology:DOID:9351); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25611); (R-RNO-1268020); (R-RNO-70635)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "19101528;2290837;3390141;33957483;3476935;3838931;3839075;6095294;6548714", "class_list": "", "function": "Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline (PubMed:2290837). The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion (PubMed:2290837)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Circadian oscillation expression of ornithine carbamoyltransferase and its significance in sleep disturbance., [RefSeq, PubMed]; Mitochondrion-derived markers, especially OCT, appeared superior to cytosol-derived markers in the detection of alcohol-induced liver injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63407", "ec_number_list": "1.16.3.1;2.1.3.3;7.1.2.2;5.6.1.7;2.5.1.39", "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0004585 ornithine carbamoyltransferase activity;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0019240 citrulline biosynthetic process;GO:0055081 monoatomic anion homeostasis;GO:0006591 ornithine metabolic process;GO:0006593 L-ornithine catabolic process;GO:0097272 ammonium homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P00481-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00774-1", "uniprot_id": "CEL2A_RAT", "mass": 28885.0, "length": 271, "protein_name": "Chymotrypsin-like elastase family member 2A", "gene_name": "Cela2a", "organism": "Rat", "refseq_name": "chymotrypsin-like elastase family member 2A precursor", "refseq_ac": "NP_036685", "gene_names_uniprotkb": "Cela2a; Ela2a; Ela2", "gene_names_refseq": "Cela2a; ELAII; Ela2a; Ela2; Elaii1", "protein_names_uniprotkb": "Chymotrypsin-like elastase family member 2A; 3.4.21.71; Elastase-2A; Elastase-2", "protein_names_refseq": "Elastase 2, pancreatic; chymotrypsin-like elastase family member 2A precursor; chymotrypsin-like elastase family, member 2A; elastase-2A; elastase-2", "tax_id": 10116, "disease": "abdominal obesity-metabolic syndrome 4 (Disease Ontology:DOID:0080945); pre-eclampsia (Disease Ontology:DOID:10591); coronary artery disease (Disease Ontology:DOID:3393); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:24332); (R-RNO-6809371)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11973405;12714330;21602471;6094548;6918221", "class_list": "", "function": "Analysis of rat mesenteric arterial bed elastase-2, expressed in mesenteric arteries and lung but not in aorta, reveals primary structural features that could contribute to the lack of activity of this enzyme toward angiotensin II., [RefSeq, PubMed]; Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity., [UniProtKB, UniProtKB]; Suggest that elastase-2 may contribute as an alternative pathway for ANG II generation when ACE is inhibited in the rat vascular tissue., [RefSeq, PubMed]; The fact that cultured mesenteric arterial bed endothelial cells are capable of producing and secreting elastase-2 represent strong evidence of a physiological role for this enzyme in the rat vasculature., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.71", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0036457 keratohyalin granule", "go_biological_process": "GO:0006508 proteolysis;GO:0050796 regulation of insulin secretion;GO:0032868 response to insulin;GO:1901143 insulin catabolic process;GO:0090330 regulation of platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00774-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01143-1", "uniprot_id": "CRH_RAT", "mass": 20680.0, "length": 187, "protein_name": "Corticotropin-releasing hormone", "gene_name": "Crh", "organism": "Rat", "refseq_name": "corticoliberin precursor", "refseq_ac": "NP_112281", "gene_names_uniprotkb": "Crh", "gene_names_refseq": "CRF; Crh", "protein_names_uniprotkb": "Corticotropin-releasing hormone; CRF; Corticoliberin; Corticotropin-releasing factor", "protein_names_refseq": "corticoliberin precursor; corticoliberin; corticotropin-releasing factor", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); extrahepatic cholestasis (Disease Ontology:DOID:13619); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); panic disorder (Disease Ontology:DOID:594); retinal degeneration (Disease Ontology:DOID:8466); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:81648); (R-RNO-373080)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11590404;1846945;1925600;3274895;34111125;35732494;37041718;38419452;3876950;39048594;6603620;8487193", "class_list": "", "function": "Corticotropin Releasing Factor Mediates KCa3.1 Inhibition, Hyperexcitability, and Seizures in Acquired Epilepsy., [RefSeq, PubMed]; Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension., [RefSeq, PubMed]; Hormone that plays a central role in whole body adaptation to stress (PubMed:1925600, PubMed:6603620, PubMed:8487193). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR1, and to a lower extent, CRHR2 (By similarity). CRH-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (By similarity). Acts as a 'placental clock' during pregnancy, regulating gestational length, fetal development and the timing of labor (By similarity). Also acts as a regulator of blastocyst implantation by promoting decidualization, regulating trophoblast invasion and facilitating maternal immune tolerance (PubMed:11590404)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model. Publication Status: Online-Only, [RefSeq, PubMed]; The effects of corticotropin-releasing factor on motor learning. Publication Status: Online-Only, [RefSeq, PubMed]; Two Adverse Early Life Events Induce Differential Changes in Brain CRH and Serotonin Systems in Rats along with Hyperphagia and Depression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017045 corticotropin-releasing hormone activity;GO:0051430 corticotropin-releasing hormone receptor 1 binding;GO:0051431 corticotropin-releasing hormone receptor 2 binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0098793 presynapse;GO:0043196 varicosity", "go_biological_process": "GO:0097305 response to alcohol;GO:1903999 negative regulation of eating behavior;GO:0098828 modulation of inhibitory postsynaptic potential;GO:0001934 positive regulation of protein phosphorylation;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P01143-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01186-1", "uniprot_id": "NEU2_RAT", "mass": 17923.0, "length": 168, "protein_name": "Vasopressin-neurophysin 2-copeptin", "gene_name": "Avp", "organism": "Rat", "refseq_name": "vasopressin-neurophysin 2-copeptin preproprotein", "refseq_ac": "NP_058688", "gene_names_uniprotkb": "Avp", "gene_names_refseq": "ADH; Avp; DI; VP; Vas", "protein_names_uniprotkb": "Vasopressin-neurophysin 2-copeptin; AVP-NPII; Arginine-vasopressin; Neurophysin-I", "protein_names_refseq": "AVP-NPII; antidiuretic hormone; arginine vasopressin (Diabetes insipidus), same as Di (conflicting physical mapping); prepropressophysin; preprovasopressin-neurophysin; vasopressin-neurophysin 2-copeptin preproprotein; vasopressin-neurophysin 2-copeptin; vasopressin-neurophysin prepropeptide", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); stroke (Disease Ontology:DOID:0051061); withdrawal disorder (Disease Ontology:DOID:0060001); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); Wernicke-Korsakoff syndrome (Disease Ontology:DOID:10915); opioid abuse (Disease Ontology:DOID:11206); neurohypophyseal diabetes insipidus (Disease Ontology:DOID:12388); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); opiate dependence (Disease Ontology:DOID:2559); temporal lobe epilepsy (Disease Ontology:DOID:3328); hyperglycemia (Disease Ontology:DOID:4195); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetes insipidus (Disease Ontology:DOID:9409); type 1 diabetes mellitus (Disease Ontology:DOID:9744); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:24221); (R-RNO-388479); (R-RNO-416476); (R-RNO-432040); (R-RNO-879518); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 7, "publication_count": 22, "publication_id_list": "10.1039/D0MO00044B;14120453;1706187;34106099;34926704;35007255;36934678;37224632;3768139;38942186;3956504;5150741;5692127;6153132;6315416;6526016;65791;6641941;7036996;7205775;891987;9523585", "class_list": "", "function": "Carrier protein that binds to and transports Arg-vasopressin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release., [UniProtKB, PubMed]; Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2)., [UniProtKB, UniProtKB]; Ionic mechanisms involved in arginine vasopressin-mediated excitation of auditory cortical and thalamic neurons., [RefSeq, PubMed]; Kidney injury molecule-1 and podocalyxin dysregulation in an arginine vasopressin induced rodent model of preeclampsia., [RefSeq, PubMed]; Paternal stress in rats increased oxytocin, oxytocin receptor, and arginine vasopressin gene expression in the male offspring amygdala with no effect on their social interaction behaviors., [RefSeq, PubMed]; Precursor of Arg-vasopressin, an antidiuretic hormone, and neurophysin 2, its carrier protein., [UniProtKB, PubMed]; Recovery from Liver Failure and Fibrosis in a Rat Portacaval Anastomosis Model after Neurointermediate Pituitary Lobectomy. Publication Status: Online-Only, [RefSeq, PubMed]; Stimulatory effects of vasopressin on progesterone production and BMP signaling by ovarian granulosa cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 20, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005185 neurohypophyseal hormone activity;GO:0031894 V1A vasopressin receptor binding;GO:0031895 V1B vasopressin receptor binding;GO:0004672 protein kinase activity;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030425 dendrite", "go_biological_process": "GO:0051970 negative regulation of transmission of nerve impulse;GO:1990089 response to nerve growth factor;GO:0002125 maternal aggressive behavior;GO:0007621 negative regulation of female receptivity;GO:0001659 temperature homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P01186-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03889-1", "uniprot_id": "NU1M_RAT", "mass": 36145.0, "length": 318, "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "Mt-nd1", "organism": "Rat", "refseq_name": "NADH dehydrogenase subunit 1", "refseq_ac": "YP_665629", "gene_names_uniprotkb": "Mt-nd1; Mtnd1; Nd1", "gene_names_refseq": "ND1", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 1; 7.1.1.2; NADH dehydrogenase subunit 1", "protein_names_refseq": "NADH dehydrogenase subunit 1", "tax_id": 10116, "disease": "Wolfram syndrome (Disease Ontology:DOID:10632); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); Friedreich ataxia (Disease Ontology:DOID:12705); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); bipolar disorder (Disease Ontology:DOID:3312); MELAS syndrome (Disease Ontology:DOID:3687); peripheral nervous system disease (Disease Ontology:DOID:574); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); rheumatoid arthritis (Disease Ontology:DOID:7148); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:26193); (R-RNO-5419276); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1672544;2504926;3190884;3399396;7664344", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O63197;Q37653", "ec_number_list": "3.1.1.29;1.3.8.7;1.3.8.8;2.1.1.-;1.-.-.-;7.1.1.2;7.1.1.9;2.1.1.320", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0030425 dendrite;GO:0031966 mitochondrial membrane;GO:0043025 neuronal cell body;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0001666 response to hypoxia;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0009410 response to xenobiotic stimulus;GO:0033194 response to hydroperoxide", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P03889-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04055-1", "uniprot_id": "PA21B_RAT", "mass": 16424.0, "length": 146, "protein_name": "Phospholipase A2", "gene_name": "Pla2g1b", "organism": "Rat", "refseq_name": "phospholipase A2 precursor", "refseq_ac": "NP_113773", "gene_names_uniprotkb": "Pla2g1b", "gene_names_refseq": "Pla2g1b", "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4; Group IB phospholipase A2; Phosphatidylcholine 2-acylhydrolase 1B", "protein_names_refseq": "group IB phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B; phospholipase A2 precursor; phospholipase A2, group 1B; phospholipase A2, group IB, pancreas", "tax_id": 10116, "disease": "", "pathway": " (rno:29526); (R-RNO-1482788); (R-RNO-1482801); (R-RNO-1482839); (R-RNO-1482922); (R-RNO-1482925); (R-RNO-1483166)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "1420353;14998370;16392040;17158102;2909239;3754861;6501264", "class_list": "", "function": "Here, we report sPLA2-IB in rat and human brain as well as in neurons in primary culture. The distribution of sPLA2-IB seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus., [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:1420353, PubMed:17158102). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:1420353, PubMed:17158102). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract (PubMed:14998370). Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370). May act in an autocrine and paracrine manner (By similarity). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.4;3.1.1.32;2.3.1.-;2.3.1.51;3.1.1.3;3.1.1.-;3.1.1.5;1.11.1.27;2.3.1.23;2.3.1.43;3.1.1.47;3.1.2.2;3.1.1.23;3.1.-.-", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity;GO:0032052 bile acid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030141 secretory granule", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0032869 cellular response to insulin stimulus;GO:0035556 intracellular signal transduction;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04055-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04167-1", "uniprot_id": "CP2B2_RAT", "mass": 55933.0, "length": 491, "protein_name": "Cytochrome P450 2B2", "gene_name": "Cyp2b2", "organism": "Rat", "refseq_name": "cytochrome P450 2B2 precursor", "refseq_ac": "NP_001185605", "gene_names_uniprotkb": "Cyp2b2; Cyp2b-2", "gene_names_refseq": "CYPIIB2; Cyp2b2; Cype", "protein_names_uniprotkb": "Cytochrome P450 2B2; 1.14.14.1; CYPIIB2; Cytochrome P450 PB4; Cytochrome P450E", "protein_names_refseq": "cytochrome P-450b type e; cytochrome P-450e-M; cytochrome P450 2B2 precursor; cytochrome P450 2B2; cytochrome P450 PB4; cytochrome P450, subfamily IIB (phenobarbital-inducible)(b, e); cytochrome P450E", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute myeloid leukemia (Disease Ontology:DOID:9119); neonatal abstinence syndrome (Disease Ontology:DOID:9828); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:361523)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "22612225;22905390;2323573;25036135;2539047;2583091;2839467;3041969;3458196;3877725;6306654;6322758;6688421;6689485", "class_list": "", "function": "Analysis of the spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450 IIB1/2 and comparison with fluorometric assay, [RefSeq, PubMed]; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB, UniProtKB]; LMP2 contributes to the NO-dependent degradation of CYP2B proteins, and induction of LMP2 may be involved in the potentiation of this degradation by IL-1., [RefSeq, PubMed]; Stimulation of hepatic heme oxygenase-1 expression by ascorbic acid deficiency caused the decrease in CYP content in liver, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64579;Q64582", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051592 response to calcium ion;GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway;GO:0010038 response to metal ion;GO:0018933 nicotine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P04167-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04182-1", "uniprot_id": "OAT_RAT", "mass": 48333.0, "length": 439, "protein_name": "Ornithine aminotransferase, mitochondrial", "gene_name": "Oat", "organism": "Rat", "refseq_name": "ornithine aminotransferase, mitochondrial precursor", "refseq_ac": "NP_071966", "gene_names_uniprotkb": "Oat", "gene_names_refseq": "Oat; rOAT", "protein_names_uniprotkb": "Ornithine aminotransferase, mitochondrial; 2.6.1.13; Ornithine--oxo-acid aminotransferase", "protein_names_refseq": "ornithine aminotransferase (gyrate atrophy); ornithine aminotransferase, mitochondrial precursor; ornithine aminotransferase, mitochondrial; ornithine--oxo-acid aminotransferase", "tax_id": 10116, "disease": "gyrate atrophy (Disease Ontology:DOID:1415); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:64313); (R-RNO-8964539)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1390894;14871882;1916291;20966424;2229004;23656379;3170546;3840476", "class_list": "", "function": "Almost all OAT protein was localized in cortical and medullary proximal straight tubules and in proximal straight tubule, Arginase II protein distribution overlapped that of OAT, [RefSeq, PubMed]; Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate., [UniProtKB, UniProtKB]; The portacaval shunt caused a marked decrease in glutamine synthetase activity and an increase in ornithine aminotransferase activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LDF6;Q6LDF7", "ec_number_list": "2.6.1.13", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0004587 ornithine aminotransferase activity;GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0055129 L-proline biosynthetic process;GO:0010121 L-arginine catabolic process to proline via ornithine;GO:0019544 L-arginine catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P04182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04634-1", "uniprot_id": "LIPF_RAT", "mass": 44588.0, "length": 395, "protein_name": "Gastric triacylglycerol lipase", "gene_name": "Lipf", "organism": "Rat", "refseq_name": "gastric triacylglycerol lipase precursor", "refseq_ac": "NP_059037", "gene_names_uniprotkb": "Lipf", "gene_names_refseq": "Lipf; RNLIP; Rnlp", "protein_names_uniprotkb": "Gastric triacylglycerol lipase; 3.1.1.3; GL; Gastric lipase; Lingual lipase", "protein_names_refseq": "GL; gastric lipase; gastric triacylglycerol lipase precursor; gastric triacylglycerol lipase; lingual lipase; lipase, gastric; prelingual lipase", "tax_id": 10116, "disease": "", "pathway": " (rno:50682); (R-RNO-192456)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12702486;27317984;3839077", "class_list": "", "function": "Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:3839077). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (By similarity)., [UniProtKB, UniProtKB, PubMed]; Lipase inhibition did not modify plasma octanoylated ghrelin concentration., [RefSeq, PubMed]; Significance of lingual lipase in the perception of a fat taste by using orlistat, a potent lipase inhibitor, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.3;2.3.1.51;3.1.1.4;3.1.1.23;3.1.1.79;3.1.1.6;3.1.1.5;3.1.1.32;3.1.1.13;3.1.1.-;3.1.1.116;3.1.1.26;3.1.1.34", "go_molecular_function": "GO:0016298 lipase activity;GO:0004806 triacylglycerol lipase activity;GO:0016615 malate dehydrogenase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005739 mitochondrion", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process;GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P04634-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04640-1", "uniprot_id": "OSTCN_RAT", "mass": 10927.0, "length": 99, "protein_name": "Osteocalcin", "gene_name": "Bglap", "organism": "Rat", "refseq_name": "osteocalcin preproprotein", "refseq_ac": "NP_038200", "gene_names_uniprotkb": "Bglap; Bglap2", "gene_names_refseq": "Bglap2; Bglap; Bgpra; Bgpr; Bgp", "protein_names_uniprotkb": "Osteocalcin; BGP; Bone Gla protein; Gamma-carboxyglutamic acid-containing protein", "protein_names_refseq": "bone Gla-protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); bone gamma-carboxyglutamate protein 2; bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin); gamma-carboxyglutamic acid-containing protein; osteocalcin preproprotein; osteocalcin", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); polycystic kidney disease (Disease Ontology:DOID:0080322); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); autosomal dominant hypocalcemia (Disease Ontology:DOID:0090109); Alport syndrome 2 (Disease Ontology:DOID:0110033); neurofibromatosis 1 (Disease Ontology:DOID:0111253); benign familial hematuria (Disease Ontology:DOID:0111365); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); prostate cancer (Disease Ontology:DOID:10283); Alport syndrome (Disease Ontology:DOID:10983); vitamin K deficiency bleeding (Disease Ontology:DOID:11249); osteoporosis (Disease Ontology:DOID:11476); nephrotic syndrome (Disease Ontology:DOID:1184); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); calcinosis (Disease Ontology:DOID:182); myopathy (Disease Ontology:DOID:423); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); collagen disease (Disease Ontology:DOID:854); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetes insipidus (Disease Ontology:DOID:9409); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:25295); (R-RNO-159740); (R-RNO-159763); (R-RNO-159782)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "27746193;2784002;2785907;3019668;31533469;32556013;3265336;3875856", "class_list": "", "function": "Acute sepsis induction resulted in reduced number of osteocalcin labelled cells in periodontal ligament region. Moreover, no significant histological differences were observed in the periodontium of rats under acute sepsis, [RefSeq, PubMed]; Binds strongly to apatite and calcium., [UniProtKB, UniProtKB]; The Potential Role of Undercarboxylated Osteocalcin Upregulation in Microvascular Insufficiency in a Rat Model of Diabetic Cardiomyopathy., [RefSeq, PubMed]; The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (By similarity). Acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (By similarity). Binds strongly to apatite and calcium upon gamma-carboxylation; this modification is essential for bone metabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development., [UniProtKB, UniProtKB]; Uncarboxylated osteocalcin potentiates insulin secretion, inhibits Kv channels and increases [Ca(2+)]i., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008147 structural constituent of bone;GO:0046914 transition metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016311 dephosphorylation;GO:1900076 regulation of cellular response to insulin stimulus;GO:1903011 negative regulation of bone development;GO:0007611 learning or memory;GO:0010043 response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P04640-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04799-1", "uniprot_id": "CP1A2_RAT", "mass": 58259.0, "length": 513, "protein_name": "Cytochrome P450 1A2", "gene_name": "Cyp1a2", "organism": "Rat", "refseq_name": "cytochrome P450 1A2", "refseq_ac": "NP_036673", "gene_names_uniprotkb": "Cyp1a2; Cyp1a-2", "gene_names_refseq": "CYPD45; Cyp1a2; P-450d; RATCYPD45", "protein_names_uniprotkb": "Cytochrome P450 1A2; 1.14.14.1; 4.2.1.152; CYPIA2; Cholesterol 25-hydroxylase; Cytochrome P-448; Cytochrome P-450d; Cytochrome P450-D; Hydroperoxy icosatetraenoate dehydratase", "protein_names_refseq": "CYPIA2; Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d); P-448; P450-D; cholesterol 25-hydroxylase; cytochrome P-448; cytochrome P-450d; cytochrome P450 1A2; cytochrome P450, 1a2; cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d); cytochrome P450-D; hydroperoxy icosatetraenoate dehydratase", "tax_id": 10116, "disease": "male infertility (Disease Ontology:DOID:12336); endometrial cancer (Disease Ontology:DOID:1380); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); porphyria cutanea tarda (Disease Ontology:DOID:3132); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:24297); (R-RNO-156581); (R-RNO-211957); (R-RNO-2142670); (R-RNO-2142816); (R-RNO-5423646); (R-RNO-9018681); (R-RNO-9027307)", "pathway_count": 8, "publication_count": 13, "publication_id_list": "1420171;1793487;24098488;28555194;29551500;2985574;34031539;3718958;3947063;6548743;6584898;7074072;7688509", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation., [UniProtKB, UniProtKB]; Acute Formaldehyde (FA) poisoning suppressed the activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity of CYP1A2 in rats. And the change of CYP450 activity caused by acute FA poisoning may be associated with FA potential carcinogenic effects on the airways., [RefSeq, PubMed]; Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-kappaB-mediated signaling pathway in vitro and in vivo., [RefSeq, PubMed]; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB]; Findings provide evidences that miR-320 might inhibit the development of Steroid-induced avascular necrosis of femoral head by targeting CYP1A2. Erratum:[Gene. 2022 Apr 30;820:146359. doi: 10.1016/j.gene.2022.146359. PMID: 35260258], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L120;Q64588", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;5.4.4.7;1.14.13.n7;1.14.14.94;5.3.99.5;1.14.14.80;5.3.99.4", "go_molecular_function": "GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0016098 monoterpenoid metabolic process;GO:0008203 cholesterol metabolic process;GO:0032496 response to lipopolysaccharide;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P04799-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04800-1", "uniprot_id": "CP3A1_RAT", "mass": 57918.0, "length": 504, "protein_name": "Cytochrome P450 3A1", "gene_name": "Cyp3a1; Cyp3a23-3a1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cyp3a1; Cyp3a23-3a1; Cyp3a-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 3A1; 1.14.14.1; CYPIIIA1; Cytochrome P450-PCN1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:25642); (R-RNO-211945); (R-RNO-211958); (R-RNO-211981); (R-RNO-5423646); (R-RNO-9027307); (R-RNO-9749641); (R-RNO-9754706); (R-RNO-9757110)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "1372436;1417000;1731631;2398038;3838989;7681660;8632755", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64580", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0032451 demethylase activity;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0050649 testosterone 6-beta-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0051384 response to glucocorticoid;GO:0006805 xenobiotic metabolic process;GO:0046686 response to cadmium ion;GO:0070989 oxidative demethylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04800-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05179-1", "uniprot_id": "CP2C7_RAT", "mass": 56187.0, "length": 490, "protein_name": "Cytochrome P450 2C7", "gene_name": "Cyp2c7", "organism": "Rat", "refseq_name": "cytochrome P450 2C7", "refseq_ac": "NP_058854", "gene_names_uniprotkb": "Cyp2c7; Cyp2c-7", "gene_names_refseq": "Cyp2c39; Cyp2c7", "protein_names_uniprotkb": "Cytochrome P450 2C7; 1.14.14.1; CYPIIC7; Cytochrome P450F; PTF1", "protein_names_refseq": "CYPIIC7; P450F; PTF1; cytochrome P450 2C7-like; cytochrome P450 2C7; cytochrome P450, 2c39; cytochrome P450F", "tax_id": 10116, "disease": "renal hypertension (Disease Ontology:DOID:1073); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:29298)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15047867;21940400;2385231;3015936;3308889;3335521;3801454", "class_list": "", "function": "CYP2C7 is an endothelial epoxyeicosatrienoic acid (EET) synthase in the female rat vasculature, by which, in nitric oxide deficiency, shear stress stimulates the release of EETs to initiate vasodilation., [RefSeq, PubMed]; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63706", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904010 response to Aroclor 1254;GO:0007584 response to nutrient;GO:0032496 response to lipopolysaccharide;GO:0045471 response to ethanol;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P05179-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05183-1", "uniprot_id": "CP3A2_RAT", "mass": 57732.0, "length": 504, "protein_name": "Cytochrome P450 3A2", "gene_name": "Cyp3a2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cyp3a2; Cyp3a-2; Cyp3a11; Cyp3a23-3a1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 3A2; 1.14.14.1; CYPIIIA2; Cytochrome P450-PCN2; Cytochrome P450/6-beta-A; Testosterone 6-beta-hydroxylase", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); alcohol-associated liver disease (Disease Ontology:DOID:0070658); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); essential hypertension (Disease Ontology:DOID:10825); cholestasis (Disease Ontology:DOID:13580); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); familial Mediterranean fever (Disease Ontology:DOID:2987); oral submucous fibrosis (Disease Ontology:DOID:5773); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:266682); (R-RNO-211945); (R-RNO-211958); (R-RNO-211981); (R-RNO-5423646); (R-RNO-9027307); (R-RNO-9749641); (R-RNO-9754706); (R-RNO-9757110)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "1417000;2043144;2398038;3785219;7681660;7979376", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVU5;Q64629;Q64672", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002933 lipid hydroxylation;GO:0008210 estrogen metabolic process;GO:0016098 monoterpenoid metabolic process;GO:0042359 vitamin D metabolic process;GO:0042369 vitamin D catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P05183-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05505-1", "uniprot_id": "COX3_RAT", "mass": 29871.0, "length": 261, "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "Mt-co3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mt-co3; Coiii; Mtco3", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 3; 7.1.1.9; Cytochrome c oxidase polypeptide III", "protein_names_refseq": "", "tax_id": 10116, "disease": "MELAS syndrome (Disease Ontology:DOID:3687)", "pathway": " (rno:26204); (R-RNO-5419276); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "24185961;2504926;6091655;7601105", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.29;7.1.1.9;7.1.1.2", "go_molecular_function": "GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0008535 respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P05505-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05507-1", "uniprot_id": "NU4LM_RAT", "mass": 10659.0, "length": 98, "protein_name": "NADH-ubiquinone oxidoreductase chain 4L", "gene_name": "Mt-nd4l", "organism": "Rat", "refseq_name": "NADH dehydrogenase subunit 4L", "refseq_ac": "YP_665637", "gene_names_uniprotkb": "Mt-nd4l; Mtnd4l; Nd4l", "gene_names_refseq": "ND4L", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 4L; 7.1.1.2; NADH dehydrogenase subunit 4L", "protein_names_refseq": "NADH dehydrogenase subunit 4L", "tax_id": 10116, "disease": "Leber hereditary optic neuropathy (Disease Ontology:DOID:705); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:26200); (R-RNO-5419276)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "24185961;2504926", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.29;7.1.1.2;7.1.1.9", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042773 ATP synthesis coupled electron transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P05507-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06907-1", "uniprot_id": "MYP0_RAT", "mass": 27571.0, "length": 248, "protein_name": "Myelin protein P0", "gene_name": "Mpz", "organism": "Rat", "refseq_name": "myelin protein P0 isoform MPZ precursor", "refseq_ac": "NP_058723", "gene_names_uniprotkb": "Mpz; P0", "gene_names_refseq": "MPP; Mpz; P0", "protein_names_uniprotkb": "Myelin protein P0; MPP; Myelin peripheral protein; Myelin protein zero", "protein_names_refseq": "myelin peripheral protein; myelin protein P0 isoform MPZ precursor; myelin protein P0; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B)", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); PCWH syndrome (Disease Ontology:DOID:0090111); Charcot-Marie-Tooth disease type 1B (Disease Ontology:DOID:0110152); Charcot-Marie-Tooth disease type 2J (Disease Ontology:DOID:0110157); Charcot-Marie-Tooth disease type 2I (Disease Ontology:DOID:0110158); Charcot-Marie-Tooth disease dominant intermediate D (Disease Ontology:DOID:0110200); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); sciatic neuropathy (Disease Ontology:DOID:11446); neuropathy (Disease Ontology:DOID:870); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:24564)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22457349;2483091;2578885;29081003;31059078;8816707", "class_list": "", "function": "Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough., [RefSeq, PubMed]; That phylogenetic emergence of L-MPZ in amphibians may be related to particular distribution and/or function in the PNS myelin, [RefSeq, PubMed]; The findings of this study indicate that treatment with 4ASA reduced the ER stress and Schwann cell death caused by 2 different MPZ mutants and suggest that ASA may be a potential therapeutic agent for CharcotMarieTooth disease ., [RefSeq, PubMed]; This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0042552 myelination;GO:0098609 cell-cell adhesion;GO:0098743 cell aggregation;GO:0045217 cell-cell junction maintenance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P06907-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08461-1", "uniprot_id": "ODP2_RAT", "mass": 67166.0, "length": 632, "protein_name": "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial", "gene_name": "Dlat", "organism": "Rat", "refseq_name": "dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial", "refseq_ac": "NP_112287", "gene_names_uniprotkb": "Dlat", "gene_names_refseq": "Dlat", "protein_names_uniprotkb": "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 2.3.1.12; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; PBC; PDC-E2; PDCE2; Pyruvate dehydrogenase complex component E2", "protein_names_refseq": "70 kDa mitochondrial autoantigen of primary biliary cirrhosis; E2; PBC; PDC-E2; PDCE2; dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; pyruvate dehydrogenase complex component E2", "tax_id": 10116, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); lactic acidosis (Disease Ontology:DOID:3650)", "pathway": " (rno:81654); (R-RNO-204174); (R-RNO-5362517); (R-RNO-9857492); (R-RNO-9861559)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "1581353;18683930;19423663;26446791;27213235;28178567;29393594;34502162;3571977", "class_list": "", "function": "The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3B7V7", "ec_number_list": "2.3.1.-;2.3.1.200;2.7.11.2;2.7.11.-;3.1.3.43;2.3.1.12;1.2.4.1;1.8.1.4", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0016407 acetyltransferase activity;GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P08461-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08721-1", "uniprot_id": "OSTP_RAT", "mass": 34963.0, "length": 317, "protein_name": "Osteopontin", "gene_name": "Spp1", "organism": "Rat", "refseq_name": "osteopontin precursor", "refseq_ac": "NP_037013", "gene_names_uniprotkb": "Spp1; 2b7; Spp-1", "gene_names_refseq": "OSP; Spp1", "protein_names_uniprotkb": "Osteopontin; Bone sialoprotein 1; SPP-1; Secreted phosphoprotein 1", "protein_names_refseq": "SPP-1; Sialoprotein (osteopontin); bone sialoprotein 1; osteopontin precursor; osteopontin-like; osteopontin", "tax_id": 10116, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); aortic dissection (Disease Ontology:DOID:0080685); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); prostate carcinoma (Disease Ontology:DOID:10286); kidney failure (Disease Ontology:DOID:1074); urinary bladder cancer (Disease Ontology:DOID:11054); biliary atresia (Disease Ontology:DOID:13608); disease of cellular proliferation (Disease Ontology:DOID:14566); renovascular hypertension (Disease Ontology:DOID:1591); pancreatic cancer (Disease Ontology:DOID:1793); calcinosis (Disease Ontology:DOID:182); melanoma (Disease Ontology:DOID:1909); hepatitis (Disease Ontology:DOID:2237); multiple sclerosis (Disease Ontology:DOID:2377); glomerulonephritis (Disease Ontology:DOID:2921); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); aortic aneurysm (Disease Ontology:DOID:3627); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); coronary restenosis (Disease Ontology:DOID:4247); radiculopathy (Disease Ontology:DOID:4306); myocardial infarction (Disease Ontology:DOID:5844); encephalomyelitis (Disease Ontology:DOID:640); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); myocarditis (Disease Ontology:DOID:820); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:25353); (R-RNO-1474228); (R-RNO-186797); (R-RNO-216083); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "1429723;22673903;2736258;3024151;3167835;3469201;36413180;36646166;36913234;38081614;38415922;8408622", "class_list": "", "function": "A miR-340/SPP1 axis inhibits the activation and proliferation of hepatic stellate cells by inhibiting the TGF-beta1/Smads pathway., [RefSeq, PubMed]; Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity., [UniProtKB, UniProtKB]; Downregulation of RUNX1-Activated Osteopontin Facilitates Burn Wound Healing by Activating the MAPK Pathways., [RefSeq, PubMed]; Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction., [UniProtKB, UniProtKB]; Osteopontin mediation of disturbed flow-induced endothelial mesenchymal transition through CD44 is a novel mechanism of neointimal hyperplasia in arteriovenous fistulae for hemodialysis access., [RefSeq, PubMed]; Silencing of secreted phosphoprotein 1 attenuates sciatic nerve injury-induced neuropathic pain: Regulating extracellular signal-regulated kinase and neuroinflammatory signaling pathways., [RefSeq, PubMed]; [Role of SPP1 in acute kidney injury induced by renal ischemia-reperfusion in rats]., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0005125 cytokine activity;GO:0050840 extracellular matrix binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0045177 apical part of cell;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006710 androgen catabolic process;GO:2000866 positive regulation of estradiol secretion;GO:0030644 intracellular chloride ion homeostasis;GO:0007155 cell adhesion;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P08721-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09606-1", "uniprot_id": "GLNA_RAT", "mass": 42268.0, "length": 373, "protein_name": "Glutamine synthetase", "gene_name": "Glul", "organism": "Rat", "refseq_name": "glutamine synthetase", "refseq_ac": "NP_058769", "gene_names_uniprotkb": "Glul; Glns", "gene_names_refseq": "Glns; Glul", "protein_names_uniprotkb": "Glutamine synthetase; 2.3.1.225; 6.3.1.2; GS; Glutamate--ammonia ligase; Palmitoyltransferase GLUL", "protein_names_refseq": "GS; Glutamine synthetase (glutamate-ammonia ligase); glutamate decarboxylase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase (glutamine synthetase); glutamine synthetase 1; glutamine synthetase; palmitoyltransferase GLUL", "tax_id": 10116, "disease": "congenital glutamine deficiency (Disease Ontology:DOID:0070544); developmental and epileptic encephalopathy 116 (Disease Ontology:DOID:0070545); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); heart disease (Disease Ontology:DOID:114); Huntington's disease (Disease Ontology:DOID:12858); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); liver disease (Disease Ontology:DOID:409); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); diabetic retinopathy (Disease Ontology:DOID:8947); amino acid metabolic disorder (Disease Ontology:DOID:9252); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24957); (R-RNO-210455); (R-RNO-8964539)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "1674354;18555765;18683930;1970548;28323;2901064;29393594;32445055;37838216;4403443;6138251;7638749", "class_list": "", "function": "Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:28323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress (By similarity). Essential for proliferation of fetal skin fibroblasts (By similarity). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development (By similarity). Involved in angiogenesis by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ. Plays a role in ribosomal 40S subunit biogenesis. Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Immunoreactivity of glutamine synthetase in satellite glia around various subpopulations of lumbar dorsal root ganglia neurons in adult rats treated with monosodium glutamate., [RefSeq, PubMed]; The alterations of glutamate transporter 1 and glutamine synthetase in the rat brain of a learned helplessness model of depression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7Q9", "ec_number_list": "2.3.1.225;2.3.1.-;6.3.1.2", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0016151 nickel cation binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043204 perikaryon", "go_biological_process": "GO:0001525 angiogenesis;GO:0006536 glutamate metabolic process;GO:0008283 cell population proliferation;GO:0032024 positive regulation of insulin secretion;GO:0051968 positive regulation of synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P09606-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C0T0-1", "uniprot_id": "LITAF_RAT", "mass": 17030.0, "length": 161, "protein_name": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "gene_name": "Litaf", "organism": "Rat", "refseq_name": "lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "refseq_ac": "NP_001099205", "gene_names_uniprotkb": "Litaf", "gene_names_refseq": "EET-1; Litaf; Pig7", "protein_names_uniprotkb": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Eet-1; Estrogen-enhanced transcript protein 1; LPS-induced TNF-alpha factor homolog", "protein_names_refseq": "LPS-induced TN factor; LPS-induced TNF-alpha factor homolog; estrogen-enhanced transcript protein 1; estrogen-responsive uterine transcript; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 1C (Disease Ontology:DOID:0110151)", "pathway": " (rno:65161)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12467897;29393594;9275072", "class_list": "", "function": "Cerebral TNFalpha is mainly produced in glia cells and that its production is dependently regulated by each stimulant, [RefSeq, PubMed]; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines. May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0050699 WW domain binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032496 response to lipopolysaccharide;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071222 cellular response to lipopolysaccharide;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C0T0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C5J3-1", "uniprot_id": "B9D2_RAT", "mass": 19208.0, "length": 175, "protein_name": "B9 domain-containing protein 2", "gene_name": "B9d2", "organism": "Rat", "refseq_name": "B9 domain-containing protein 2", "refseq_ac": "NP_001100964", "gene_names_uniprotkb": "B9d2", "gene_names_refseq": "B9d2; RGD1566122", "protein_names_uniprotkb": "B9 domain-containing protein 2", "protein_names_refseq": "B9 domain-containing protein 2; B9 protein domain 2", "tax_id": 10116, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); ciliopathy (Disease Ontology:DOID:0060340)", "pathway": " (rno:308443); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5620912); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "39455645", "class_list": "", "function": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes., [UniProtKB, UniProtKB, UniProtKB]; New functions of B9D2 in tight junctions and epithelial polarity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0016020 membrane;GO:0005930 axoneme;GO:0036038 MKS complex", "go_biological_process": "GO:0060271 cilium assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C5J3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C8N6-1", "uniprot_id": "NEMP2_RAT", "mass": 47681.0, "length": 421, "protein_name": "Nuclear envelope integral membrane protein 2", "gene_name": "Nemp2", "organism": "Rat", "refseq_name": "nuclear envelope integral membrane protein 2 precursor", "refseq_ac": "NP_001128114", "gene_names_uniprotkb": "Nemp2; Tmem194b", "gene_names_refseq": "Nemp2; RGD1560421; Tmem194b", "protein_names_uniprotkb": "Nuclear envelope integral membrane protein 2", "protein_names_refseq": "nuclear envelope integral membrane protein 2 precursor; transmembrane protein 194B", "tax_id": 10116, "disease": "", "pathway": " (rno:503257)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005637 nuclear inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C8N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CD96-1", "uniprot_id": "OCC1_RAT", "mass": 6375.0, "length": 63, "protein_name": "Overexpressed in colon carcinoma 1 protein homolog", "gene_name": "C7h12orf75", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "C7h12orf75; LOC100910996", "gene_names_refseq": "", "protein_names_uniprotkb": "Overexpressed in colon carcinoma 1 protein homolog; OCC-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:100910996)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0CD96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DL28-1", "uniprot_id": "FBXW8_RAT", "mass": 67819.0, "length": 596, "protein_name": "F-box/WD repeat-containing protein 8", "gene_name": "Fbxw8", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fbxw8", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 8; F-box and WD-40 domain-containing protein 8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:304522); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21572988", "class_list": "", "function": "Substrate-recognition component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (By similarity). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (By similarity). The Cul7-RING(FBXW8) complex also mediates ubiquitination of phosphorylated cyclin-D1 (CCND1) (By similarity). The Cul7-RING(FBXW8) complex is however not a major regulator of CCND1 stability during the G1/S transition (By similarity). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0031467 Cul7-RING ubiquitin ligase complex;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0008283 cell population proliferation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0060271 cilium assembly;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0DL28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DP76-1", "uniprot_id": "ELA_RAT", "mass": 6823.0, "length": 54, "protein_name": "Apelin receptor early endogenous ligand", "gene_name": "Apela", "organism": "Rat", "refseq_name": "apelin receptor early endogenous ligand precursor", "refseq_ac": "NP_001386353", "gene_names_uniprotkb": "Apela; Ela; Tdl", "gene_names_refseq": "Apela; ELA; Tdl", "protein_names_uniprotkb": "Apelin receptor early endogenous ligand; ELA; Protein Elabela; Protein Toddler", "protein_names_refseq": "Protein Elabela; Protein Toddler; apelin receptor early endogenous ligand precursor", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591)", "pathway": " (rno:103693925)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "26611206;28137936;34453661;35472496;36878020", "class_list": "", "function": "Conclude that apela is present in the adult heart, is upregulated in post-infarction cardiac remodeling, and increases cardiac contractility in an ERK1/2-dependent manner, [RefSeq, PubMed]; ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats., [RefSeq, PubMed]; Elabela prevents angiotensin II-induced apoptosis and inflammation in rat aortic adventitial fibroblasts via the activation of FGF21-ACE2 signaling., [RefSeq, PubMed]; Peptide hormone that functions as endogenous ligand for the G protein-coupled apelin receptor (APLNR/APJ), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:28137936). Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR (By similarity). Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs (By similarity). On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor (By similarity). Required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:26611206, PubMed:28137936). Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating APLNR. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Plays a role in placental vascular development; promotes placental trophoblast invasion and spiral artery remodeling in the uterus (By similarity). Involved in the regulation of maternal cardiovascular homeostasis to prevent gestational hypertension and for potent cardioprotective functions during heart failure (PubMed:26611206). Mediates myocardial contractility in an ERK1/2-dependent manner (PubMed:26611206)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Vascular Functional Effect Mechanisms of Elabela in Rat Thoracic Aorta., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0031704 apelin receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:1901165 positive regulation of trophoblast cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0DP76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10065-1", "uniprot_id": "CRGA_RAT", "mass": 21094.0, "length": 174, "protein_name": "Gamma-crystallin A", "gene_name": "Cryga", "organism": "Rat", "refseq_name": "gamma-crystallin A", "refseq_ac": "NP_001074405", "gene_names_uniprotkb": "Cryga", "gene_names_refseq": "Cryga", "protein_names_uniprotkb": "Gamma-crystallin A; Gamma-A-crystallin; Gamma-crystallin 1-1", "protein_names_refseq": "CRY-gamma-A; gamma-A-crystallin; gamma-crystallin 1-1; gamma-crystallin A", "tax_id": 10116, "disease": "cataract (Disease Ontology:DOID:83)", "pathway": " (rno:684028)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2777080;3783678", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0001654 eye development;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P10065-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10158-1", "uniprot_id": "FOSL1_RAT", "mass": 30115.0, "length": 275, "protein_name": "Fos-related antigen 1", "gene_name": "Ccdc85b; Fosl1", "organism": "Rat", "refseq_name": "fos-related antigen 1", "refseq_ac": "NP_037085", "gene_names_uniprotkb": "Ccdc85b; Fosl1; Ccdc85b; Fosl1; Fra1", "gene_names_refseq": "Fosl1; Fra-1; fra-1", "protein_names_uniprotkb": "Fos-related antigen 1; FRA-1", "protein_names_refseq": "FOS like 1, AP-1 trancription factor subunit; fos-like antigen 1; fos-related antigen 1", "tax_id": 10116, "disease": "", "pathway": " (rno:25445)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "30892941;3133553;34973528;36634215;37949219;7791782", "class_list": "", "function": "FOSL1 modulates Schwann cell responses in the wound microenvironment and regulates peripheral nerve regeneration., [RefSeq, PubMed]; Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury., [RefSeq, PubMed]; Identification of the Fosl1/AMPK/autophagy axis involved in apoptotic and inflammatory effects following spinal cord injury., [RefSeq, PubMed]; Results identify that Fra-1 plays a novel and key role in promoting vascular aging by directly binding and transcriptionally activating p21 and p16 signaling, suggesting intervention of Fra-1 is a potential strategy for preventing aging-associated cardiovascular disorders, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8K7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0042734 presynaptic membrane;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005813 centrosome", "go_biological_process": "GO:0007296 vitellogenesis;GO:0001701 in utero embryonic development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10158-1", "record_type": "protein" } ]