[ { "uniprot_canonical_ac": "D3ZUZ4-1", "uniprot_id": "D3ZUZ4_RAT", "mass": 46569.0, "length": 409, "protein_name": "FAM20B, glycosaminoglycan xylosylkinase", "gene_name": "Fam20b", "organism": "Rat", "refseq_name": "glycosaminoglycan xylosylkinase", "refseq_ac": "NP_001100657", "gene_names_uniprotkb": "Fam20b", "gene_names_refseq": "Fam20b; RGD1311162", "protein_names_uniprotkb": "FAM20B, glycosaminoglycan xylosylkinase", "protein_names_refseq": "family with sequence similarity 20, member B; glycosaminoglycan xylosylkinase", "tax_id": 10116, "disease": "", "pathway": " (rno:304885); (R-RNO-1971475)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016773 phosphotransferase activity, alcohol group as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZUZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZVC4-1", "uniprot_id": "D3ZVC4_RAT", "mass": 94294.0, "length": 823, "protein_name": "Apoptosis-resistant E3 ubiquitin protein ligase 1", "gene_name": "Arel1", "organism": "Rat", "refseq_name": "apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1", "refseq_ac": "NP_001100214", "gene_names_uniprotkb": "Arel1; RGD1307597", "gene_names_refseq": "Arel1; RGD1307597", "protein_names_uniprotkb": "Apoptosis-resistant E3 ubiquitin protein ligase 1; 2.3.2.26; Apoptosis-resistant HECT-type E3 ubiquitin transferase 1", "protein_names_refseq": "apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:299197); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro. Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.32;2.3.2.31;2.3.2.23;2.3.2.27;2.3.2.34;2.3.2.24;2.3.2.-;2.3.2.25", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0050727 regulation of inflammatory response;GO:0016567 protein ubiquitination;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZVD5-1", "uniprot_id": "D3ZVD5_RAT", "mass": 72684.0, "length": 663, "protein_name": "Transforming growth factor beta activator LRRC32", "gene_name": "Lrrc32", "organism": "Rat", "refseq_name": "transforming growth factor beta activator LRRC32 precursor", "refseq_ac": "NP_001163905", "gene_names_uniprotkb": "Lrrc32", "gene_names_refseq": "Garp; Lrrc32", "protein_names_uniprotkb": "Transforming growth factor beta activator LRRC32; Leucine-rich repeat-containing protein 32", "protein_names_refseq": "glycoprotein A repetitions predominant; leucine-rich repeat-containing protein 32; transforming growth factor beta activator LRRC32 precursor; transforming growth factor beta activator LRRC32", "tax_id": 10116, "disease": "", "pathway": " (rno:293135)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050431 transforming growth factor beta binding;GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0046007 negative regulation of activated T cell proliferation;GO:0001818 negative regulation of cytokine production;GO:0062009 secondary palate development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZVD7-1", "uniprot_id": "D3ZVD7_RAT", "mass": 40213.0, "length": 351, "protein_name": "Keratocan", "gene_name": "Kera", "organism": "Rat", "refseq_name": "keratocan precursor", "refseq_ac": "NP_001101557", "gene_names_uniprotkb": "Kera", "gene_names_refseq": "Kera", "protein_names_uniprotkb": "Keratocan", "protein_names_refseq": "keratocan precursor", "tax_id": 10116, "disease": "cornea plana (Disease Ontology:DOID:0060287); keratoconus (Disease Ontology:DOID:10126); arcus senilis (Disease Ontology:DOID:11342); corneal dystrophy (Disease Ontology:DOID:2566)", "pathway": " (rno:314771); (R-RNO-2022854); (R-RNO-2022857)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32235499", "class_list": "", "function": "Immunolocalization of Keratan Sulfate in Rat Spinal Tissues Using the Keratanase Generated BKS-1(+) Neoepitope: Correlation of Expression Patterns with the Class II SLRPs, Lumican and Keratocan. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0061303 cornea development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZVD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZVK7-1", "uniprot_id": "D3ZVK7_RAT", "mass": 14150.0, "length": 130, "protein_name": "Histone H2A", "gene_name": "H2ac4", "organism": "Rat", "refseq_name": "H2A clustered histone 4", "refseq_ac": "NP_001102893", "gene_names_uniprotkb": "H2ac4", "gene_names_refseq": "H2ac4; Hist1h2ak", "protein_names_uniprotkb": "Histone H2A", "protein_names_refseq": "H2A clustered histone 4; histone cluster 1, H2ak", "tax_id": 10116, "disease": "", "pathway": " (rno:680615); (R-RNO-110330); (R-RNO-110331); (R-RNO-212300); (R-RNO-2299718); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559586); (R-RNO-3214815); (R-RNO-3214858); (R-RNO-427359); (R-RNO-427413); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-5625886); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-5689901); (R-RNO-606279); (R-RNO-68616); (R-RNO-73728); (R-RNO-73772); (R-RNO-8936459); (R-RNO-9018519); (R-RNO-9764725); (R-RNO-9841922); (R-RNO-9843940); (R-RNO-9843970); (R-RNO-9909649); (R-RNO-9940951); (R-RNO-9943411); (R-RNO-9943962); (R-RNO-9970672)", "pathway_count": 33, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZVQ0-1", "uniprot_id": "D3ZVQ0_RAT", "mass": 95779.0, "length": 858, "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "Usp5", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 5 isoform 1", "refseq_ac": "NP_001100089", "gene_names_uniprotkb": "Usp5", "gene_names_refseq": "Usp5", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 5 isoform 1; ubiquitin carboxyl-terminal hydrolase 5-like; ubiquitin carboxyl-terminal hydrolase 5; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5 (isopeptidase T)", "tax_id": 10116, "disease": "", "pathway": " (rno:297593); (R-RNO-5689880); (R-RNO-8866652)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "18683930;22673903;23375434", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]; Local administration of NO may prevent neointimal hyperplasia by inhibiting isopeptidase T levels and activity in the vasculature, thereby inhibiting the 26S proteasome in vascular smooth muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043130 ubiquitin binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:0098793 presynapse", "go_biological_process": "GO:0006508 proteolysis;GO:0031647 regulation of protein stability;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3ZVQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZVZ1-1", "uniprot_id": "D3ZVZ1_RAT", "mass": 34738.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or1j13c", "organism": "Rat", "refseq_name": "olfactory receptor Olr408", "refseq_ac": "NP_001000384", "gene_names_uniprotkb": "Or1j13c", "gene_names_refseq": "Olr408; Or1j13c; ratchr3-16175632-16176570_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 408; olfactory receptor Olr408; olfactory receptor gene Olr408", "tax_id": 10116, "disease": "", "pathway": " (rno:296672)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ABJ6-1", "uniprot_id": "D4ABJ6_RAT", "mass": 194777.0, "length": 1776, "protein_name": "TOG array regulator of axonemal microtubules protein 1", "gene_name": "Togaram1", "organism": "Rat", "refseq_name": "TOG array regulator of axonemal microtubules protein 1", "refseq_ac": "NP_001414223", "gene_names_uniprotkb": "Togaram1; Fam179b", "gene_names_refseq": "Fam179b; RGD1310474; Togaram1", "protein_names_uniprotkb": "TOG array regulator of axonemal microtubules protein 1; Crescerin-1; Protein FAM179B", "protein_names_refseq": "TOG array regulator of axonemal microtubules protein 1; family with sequence similarity 179, member B", "tax_id": 10116, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); ciliopathy (Disease Ontology:DOID:0060340)", "pathway": " (rno:314169)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length. Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005929 cilium;GO:0005930 axoneme;GO:0005881 cytoplasmic microtubule;GO:0005874 microtubule;GO:0036064 ciliary basal body", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0030030 cell projection organization;GO:0060271 cilium assembly;GO:0031116 positive regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4ABJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZWE3-1", "uniprot_id": "D3ZWE3_RAT", "mass": 67660.0, "length": 587, "protein_name": "POF1B, actin binding protein", "gene_name": "Pof1b", "organism": "Rat", "refseq_name": "protein POF1B", "refseq_ac": "NP_001100404", "gene_names_uniprotkb": "Pof1b", "gene_names_refseq": "Pof1b; RGD1560798", "protein_names_uniprotkb": "POF1B, actin binding protein", "protein_names_refseq": "premature ovarian failure 1B; protein POF1B", "tax_id": 10116, "disease": "primary ovarian insufficiency 2B (Disease Ontology:DOID:0080859)", "pathway": " (rno:302328)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005884 actin filament;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0030057 desmosome", "go_biological_process": "GO:0007015 actin filament organization;GO:0030036 actin cytoskeleton organization;GO:0070830 bicellular tight junction assembly;GO:0003382 epithelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZWE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZWG7-1", "uniprot_id": "D3ZWG7_RAT", "mass": 35547.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or8k27", "organism": "Rat", "refseq_name": "olfactory receptor Olr499", "refseq_ac": "NP_001000931", "gene_names_uniprotkb": "Or8k27", "gene_names_refseq": "Olr499; Or8k27", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 499; olfactory receptor 8K1-like; olfactory receptor 8K3-like; olfactory receptor Olr499; olfactory receptor gene Olr499", "tax_id": 10116, "disease": "", "pathway": " (rno:405251)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZXT0", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZWG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZWI0-1", "uniprot_id": "D3ZWI0_RAT", "mass": 160326.0, "length": 1427, "protein_name": "hyaluronoglucosaminidase", "gene_name": "Cemip", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cemip; RGD1305254", "gene_names_refseq": "", "protein_names_uniprotkb": "hyaluronoglucosaminidase; 3.2.1.35", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-2160916)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.1.35", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding;GO:0004415 hyalurononglucosaminidase activity;GO:0032050 clathrin heavy chain binding;GO:0046923 ER retention sequence binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0010800 positive regulation of peptidyl-threonine phosphorylation;GO:0030335 positive regulation of cell migration;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol;GO:0007605 sensory perception of sound;GO:0090314 positive regulation of protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZWI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZWL0-1", "uniprot_id": "D3ZWL0_RAT", "mass": 15803.0, "length": 135, "protein_name": "Ribosomal protein L32 like 1", "gene_name": "Rpl32l1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rpl32l1; AABR07069585.1; RGD1563958", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosomal protein L32 like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZWL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZWQ0-1", "uniprot_id": "D3ZWQ0_RAT", "mass": 101428.0, "length": 978, "protein_name": "Proline-rich transmembrane protein 3", "gene_name": "Prrt3", "organism": "Rat", "refseq_name": "proline-rich transmembrane protein 3 precursor", "refseq_ac": "NP_001296392", "gene_names_uniprotkb": "Prrt3", "gene_names_refseq": "Prrt3; 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Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0022626 cytosolic ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006412 translation;GO:0019941 modification-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A0Q3-1", "uniprot_id": "D4A0Q3_RAT", "mass": 50443.0, "length": 455, "protein_name": "WD repeat domain 4", "gene_name": "Wdr4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Wdr4", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat domain 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); Galloway-Mowat syndrome (Disease Ontology:DOID:0080694); microcephaly, growth deficiency, seizures, and brain malformations (Disease Ontology:DOID:0081051)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043527 tRNA methyltransferase complex;GO:0106143 tRNA (m7G46) methyltransferase complex", "go_biological_process": "GO:0006400 tRNA modification;GO:0006974 DNA damage response;GO:0106004 tRNA (guanine-N7)-methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A0R1-1", "uniprot_id": "D4A0R1_RAT", "mass": 127805.0, "length": 1151, "protein_name": "Zinc finger protein ZFPM2", "gene_name": "Zfpm2", "organism": "Rat", "refseq_name": "zinc finger protein ZFPM2 isoform 1", "refseq_ac": "NP_001123973", "gene_names_uniprotkb": "Zfpm2", "gene_names_refseq": "FOG-2; Zfpm2", "protein_names_uniprotkb": "Zinc finger protein ZFPM2; Friend of GATA protein 2; Zinc finger protein multitype 2", "protein_names_refseq": "zinc finger protein ZFPM2 isoform 1; zinc finger protein ZFPM2", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); tricuspid atresia (Disease Ontology:DOID:0080169); 46,XY sex reversal 9 (Disease Ontology:DOID:0111770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (rno:314930); (R-RNO-983231)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0003192 mitral valve formation;GO:0003195 tricuspid valve formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0R1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A138-1", "uniprot_id": "D4A138_RAT", "mass": 30977.0, "length": 292, "protein_name": "Nanos C2HC-type zinc finger 3", "gene_name": "Nanos3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nanos3", "gene_names_refseq": "", "protein_names_uniprotkb": "Nanos C2HC-type zinc finger 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:288909)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0017148 negative regulation of translation;GO:0007281 germ cell development;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A138-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A164-1", "uniprot_id": "D4A164_RAT", "mass": 115980.0, "length": 1013, "protein_name": "Nebulette", "gene_name": "Nebl", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nebl", "gene_names_refseq": "", "protein_names_uniprotkb": "Nebulette", "protein_names_refseq": "", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22673903;34502162", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0008092 cytoskeletal protein binding;GO:0005523 tropomyosin binding;GO:0031005 filamin binding", "go_cellular_component": "GO:0001725 stress fiber;GO:0030018 Z disc", "go_biological_process": "GO:0071691 cardiac muscle thin filament assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A182-1", "uniprot_id": "D4A182_RAT", "mass": 54783.0, "length": 493, "protein_name": "Protein naked cuticle homolog", "gene_name": "Nkd2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nkd2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein naked cuticle homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:308068)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell autonomous antagonist of the canonical Wnt signaling pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019838 growth factor binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0071944 cell periphery", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0072659 protein localization to plasma membrane;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0010954 positive regulation of protein processing;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A1D4-1", "uniprot_id": "D4A1D4_RAT", "mass": 24432.0, "length": 222, "protein_name": "Uridine diphosphate glucose pyrophosphatase NUDT14", "gene_name": "Nudt14", "organism": "Rat", "refseq_name": "uridine diphosphate glucose pyrophosphatase NUDT14", "refseq_ac": "NP_001100230", "gene_names_uniprotkb": "Nudt14", "gene_names_refseq": "Nudt14", "protein_names_uniprotkb": "Uridine diphosphate glucose pyrophosphatase NUDT14; 3.6.1.45; Nucleoside diphosphate-linked moiety X motif 14", "protein_names_refseq": "nudix (nucleoside diphosphate linked moiety X)-type motif 14; nudix-type motif 14; uridine diphosphate glucose pyrophosphatase NUDT14; uridine diphosphate glucose pyrophosphatase", "tax_id": 10116, "disease": "", "pathway": " (rno:299346); (R-RNO-480985)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.1.45", "go_molecular_function": "GO:0008768 UDP-sugar diphosphatase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0047631 ADP-ribose diphosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019693 ribose phosphate metabolic process;GO:0006753 nucleoside phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A1D4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A1U7-1", "uniprot_id": "D4A1U7_RAT", "mass": 89287.0, "length": 795, "protein_name": "Round spermatid basic protein 1", "gene_name": "Rsbn1", "organism": "Rat", "refseq_name": "lysine-specific demethylase 9", "refseq_ac": "NP_001178639", "gene_names_uniprotkb": "Rsbn1", "gene_names_refseq": "RGD1307231; Rsbn1", "protein_names_uniprotkb": "Round spermatid basic protein 1", "protein_names_refseq": "lysine-specific demethylase 9; rosbin, round spermatid basic protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:310749)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A1U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A1W1-1", "uniprot_id": "D4A1W1_RAT", "mass": 75362.0, "length": 677, "protein_name": "Holliday junction recognition protein", "gene_name": "Hjurp", "organism": "Rat", "refseq_name": "Holliday junction recognition protein isoform X1", "refseq_ac": "XP_006245455", "gene_names_uniprotkb": "Hjurp", "gene_names_refseq": "Hjurp; RGD1305846", "protein_names_uniprotkb": "Holliday junction recognition protein", "protein_names_refseq": "Holliday junction recognition protein isoform X1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-606279); (R-RNO-69273)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0043254 regulation of protein-containing complex assembly;GO:0034080 CENP-A containing chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A1W1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A1W8-1", "uniprot_id": "MTP_RAT", "mass": 99187.0, "length": 896, "protein_name": "Microsomal triglyceride transfer protein large subunit", "gene_name": "Mttp", "organism": "Rat", "refseq_name": "microsomal triglyceride transfer protein large subunit precursor", "refseq_ac": "NP_001101197", "gene_names_uniprotkb": "Mttp; Mtp", "gene_names_refseq": "MTP; Mttp", "protein_names_uniprotkb": "Microsomal triglyceride transfer protein large subunit", "protein_names_refseq": "microsomal triglyceride transfer protein large subunit precursor; microsomal triglyceride transfer protein large subunit", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); familial hypercholesterolemia (Disease Ontology:DOID:13810); abetalipoproteinemia (Disease Ontology:DOID:1386); hyperinsulinism (Disease Ontology:DOID:2018); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:310900); (R-RNO-8866423); (R-RNO-8963888); (R-RNO-8964041)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11830580;15897609;16478722;26092479;26184122;28270444", "class_list": "", "function": "Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Coordinated up-regulation of Mttp, Apob, Hnf1a, Hnf4a, Fasn, Gpam and Dgat (1 and 2) gene expressions may contribute to the increase in circulating and liver concentrations of TAGs after lipectomy in an experimental rat model, [RefSeq, PubMed]; Data suggest that Mttp content of liver microsomes can be altered by dietary factors; here, Mttp is up-regulated in liver microsomes of obese rats with dietary supplementation of the fatty acid alpha-linolenic acid; animal physical conditioning (exercise) appears to up-regulate Mttp in liver microsomes in an independent manner., [RefSeq, PubMed]; Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons [microsomal triglyceride transfer protein (MTP)], [RefSeq, PubMed]; Tau supplementation prevented obesity and hepatic TG deposition by upregulating MTP mRNA, ameliorating hepatic lipid efflux, and consequently enhancing PPAR-alpha which increases lipid oxidation through ACO and CPT-1a gene expressions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.-.-", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0034185 apolipoprotein binding;GO:0046982 protein heterodimerization activity;GO:0005548 phospholipid transporter activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex;GO:0031982 vesicle", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006641 triglyceride metabolic process;GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D4A1W8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A2S0-1", "uniprot_id": "D4A2S0_RAT", "mass": 35920.0, "length": 321, "protein_name": "Olfactory receptor", "gene_name": "Or52n2b", "organism": "Rat", "refseq_name": "olfactory receptor Olr175", "refseq_ac": "NP_001001029", "gene_names_uniprotkb": "Or52n2b", "gene_names_refseq": "Olr175; Or52n2b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 175; olfactory receptor Olr175; olfactory receptor gene Olr175", "tax_id": 10116, "disease": "", "pathway": " (rno:405915)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2S0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A2S5-1", "uniprot_id": "D4A2S5_RAT", "mass": 35307.0, "length": 315, "protein_name": "Olfactory receptor", "gene_name": "Or8g24", "organism": "Rat", "refseq_name": "olfactory receptor Olr1279", "refseq_ac": "NP_001000961", "gene_names_uniprotkb": "Or8g24", "gene_names_refseq": "Olr1279; Or8g24", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1279; olfactory receptor 150-like; olfactory receptor Olr1279; olfactory receptor gene Olr1279", "tax_id": 10116, "disease": "", "pathway": " (rno:405313)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2S5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A2W3-1", "uniprot_id": "D4A2W3_RAT", "mass": 35400.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or52e4", "organism": "Rat", "refseq_name": "olfactory receptor Olr188", "refseq_ac": "NP_001001032", "gene_names_uniprotkb": "Or52e4", "gene_names_refseq": "Olr188; Or52e4", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 188; olfactory receptor Olr188; olfactory receptor gene Olr188", "tax_id": 10116, "disease": "", "pathway": " (rno:405918)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2W3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A365-1", "uniprot_id": "D4A365_RAT", "mass": 138245.0, "length": 1255, "protein_name": "Zinc finger and BTB domain containing 40", "gene_name": "Zbtb40", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 40 isoform 2", "refseq_ac": "NP_001178800", "gene_names_uniprotkb": "Zbtb40", "gene_names_refseq": "RGD1309866; Zbtb40", "protein_names_uniprotkb": "Zinc finger and BTB domain containing 40", "protein_names_refseq": "zinc finger and BTB domain-containing protein 40 isoform 2; zinc finger and BTB domain-containing protein 40", "tax_id": 10116, "disease": "", "pathway": " (rno:362635)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A365-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A3I1-1", "uniprot_id": "D4A3I1_RAT", "mass": 22708.0, "length": 200, "protein_name": "Tumor necrosis factor ligand superfamily member 18", "gene_name": "Tnfsf18", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tnfsf18", "gene_names_refseq": "", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 18; Glucocorticoid-induced TNF-related ligand", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-5669034)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0032813 tumor necrosis factor receptor superfamily binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:0090026 positive regulation of monocyte chemotaxis;GO:0050729 positive regulation of inflammatory response;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0043254 regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3I1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A3I3-1", "uniprot_id": "D4A3I3_RAT", "mass": 32376.0, "length": 275, "protein_name": "Myb/SANT-like DNA-binding domain-containing protein 3", "gene_name": "Msantd3", "organism": "Rat", "refseq_name": "myb/SANT-like DNA-binding domain-containing protein 3", "refseq_ac": "NP_001102134", "gene_names_uniprotkb": "Msantd3", "gene_names_refseq": "Msantd3; 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Publication Status: Online-Only, [RefSeq, PubMed]; The AKT1-FOXO4 axis reciprocally regulates hemochorial placentation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D4A433-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A4D5-1", "uniprot_id": "D4A4D5_RAT", "mass": 11706.0, "length": 115, "protein_name": "Large ribosomal subunit protein P2", "gene_name": "Rplp2l2", "organism": "Rat", "refseq_name": "large ribosomal subunit protein P2-like", "refseq_ac": "XP_038949887", "gene_names_uniprotkb": "Rplp2l2; LOC498555", "gene_names_refseq": "Rplp2l2", "protein_names_uniprotkb": "Large ribosomal subunit protein P2; 60S acidic ribosomal protein P2", "protein_names_refseq": "large ribosomal subunit protein P2-like", "tax_id": 10116, "disease": "", "pathway": " (rno:498555)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in the elongation step of protein synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002182 cytoplasmic translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A4D5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A4H5-1", "uniprot_id": "D4A4H5_RAT", "mass": 24056.0, "length": 219, "protein_name": "Stromal cell derived factor 2", "gene_name": "Sdf2", "organism": "Rat", "refseq_name": "stromal cell-derived factor 2 precursor", "refseq_ac": "NP_001099273", "gene_names_uniprotkb": "Sdf2", "gene_names_refseq": "Sdf2", "protein_names_uniprotkb": "Stromal cell derived factor 2", "protein_names_refseq": "stromal cell-derived factor 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:287470)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A4H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A4R7-1", "uniprot_id": "D4A4R7_RAT", "mass": 46986.0, "length": 412, "protein_name": "Serpin family A member 1F", "gene_name": "Serpina1f", "organism": "Rat", "refseq_name": "alpha-1-antitrypsin 1-6 precursor", "refseq_ac": "NP_001101524", "gene_names_uniprotkb": "Serpina1f", "gene_names_refseq": "RGD1307899; 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impotence (Disease Ontology:DOID:1875)", "pathway": " (rno:311827); (R-RNO-5173214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050436 microfibril binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060481 lobar bronchus epithelium development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A4X6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A558-1", "uniprot_id": "D4A558_RAT", "mass": 24795.0, "length": 231, "protein_name": "Homeobox protein MIXL1", "gene_name": "Mixl1", "organism": "Rat", "refseq_name": "homeobox protein MIXL1", "refseq_ac": "NP_001099449", "gene_names_uniprotkb": "Mixl1", "gene_names_refseq": "Mixl1", "protein_names_uniprotkb": "Homeobox protein MIXL1; Homeodomain protein MIX; MIX1 homeobox-like protein 1; Mix.1 homeobox-like protein", "protein_names_refseq": "homeobox protein MIXL1", "tax_id": 10116, "disease": "", "pathway": " (rno:289311)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A558-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A561-1", "uniprot_id": "D4A561_RAT", "mass": 14554.0, "length": 135, "protein_name": "RIKEN cDNA 9530082P21 gene like", "gene_name": "9530082P21Rikl", "organism": "Rat", "refseq_name": "uncharacterized protein LOC360487", "refseq_ac": "NP_001128041", "gene_names_uniprotkb": "9530082P21Rikl; RGD1561157", "gene_names_refseq": "9530082P21Rikl; RGD1561157", "protein_names_uniprotkb": "RIKEN cDNA 9530082P21 gene like", "protein_names_refseq": "uncharacterized protein LOC360487", "tax_id": 10116, "disease": "", "pathway": " (rno:360487)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A561-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A584-1", "uniprot_id": "D4A584_RAT", "mass": 93571.0, "length": 822, "protein_name": "Tyrosine-protein kinase", "gene_name": "Fes", "organism": "Rat", "refseq_name": "tyrosine-protein kinase Fes/Fps", "refseq_ac": "NP_001101958", "gene_names_uniprotkb": "Fes", "gene_names_refseq": "Fes; RGD1564385", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "feline sarcoma oncogene; tyrosine-protein kinase Fes/Fps", "tax_id": 10116, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:361597); (R-RNO-1433557); (R-RNO-399954); (R-RNO-399956)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.10.2;2.7.12.2;2.7.1.40;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.32;2.7.1.82;2.7.11.23;3.6.5.2;2.7.11.17;2.4.99.18", "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0010976 positive regulation of neuron projection development;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0030155 regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A584-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A5G4-1", "uniprot_id": "D4A5G4_RAT", "mass": 34245.0, "length": 299, "protein_name": "Sperm flagellar protein 1-like", "gene_name": "LOC103691261", "organism": "Rat", "refseq_name": "sperm flagellar protein 1-like isoform X1", "refseq_ac": "XP_008758240", "gene_names_uniprotkb": "LOC103691261", "gene_names_refseq": "LOC103691261", "protein_names_uniprotkb": "Sperm flagellar protein 1-like", "protein_names_refseq": "sperm flagellar protein 1-like isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:103691261)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005930 axoneme", "go_biological_process": "GO:0051493 regulation of cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A5G4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A707-1", "uniprot_id": "D4A707_RAT", "mass": 13411.0, "length": 127, "protein_name": "Ly6/Plaur domain containing 2", "gene_name": "Lypd2", "organism": "Rat", "refseq_name": "ly6/PLAUR domain-containing protein 2 precursor", "refseq_ac": "NP_001124017", "gene_names_uniprotkb": "Lypd2", "gene_names_refseq": "Lypd2", "protein_names_uniprotkb": "Ly6/Plaur domain containing 2", "protein_names_refseq": "ly6/PLAUR domain-containing protein 2 precursor; ly6/PLAUR domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:300017); (R-RNO-163125)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A707-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A7J8-1", "uniprot_id": "D4A7J8_RAT", "mass": 58343.0, "length": 521, "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp4", "gene_name": "Prpf4", "organism": "Rat", "refseq_name": "U4/U6 small nuclear ribonucleoprotein Prp4", "refseq_ac": "NP_001100129", "gene_names_uniprotkb": "Prpf4", "gene_names_refseq": "Prpf4", "protein_names_uniprotkb": "U4/U6 small nuclear ribonucleoprotein Prp4; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4", "protein_names_refseq": "PRP4 pre-mRNA processing factor 4 homolog; U4/U6 small nuclear ribonucleoprotein Prp4; pre-mRNA splicing tri-snRNP complex factor 4", "tax_id": 10116, "disease": "retinitis pigmentosa 70 (Disease Ontology:DOID:0110392); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:298095)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0015030 Cajal body;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A7J8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A7M3-1", "uniprot_id": "D4A7M3_RAT", "mass": 44131.0, "length": 392, "protein_name": "OTU domain-containing protein 3", "gene_name": "Otud3", "organism": "Rat", "refseq_name": "OTU domain-containing protein 3", "refseq_ac": "NP_001178912", "gene_names_uniprotkb": "Otud3", "gene_names_refseq": "Otud3; RGD1560468", "protein_names_uniprotkb": "OTU domain-containing protein 3; 3.4.19.12", "protein_names_refseq": "OTU domain containing 3; OTU domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:500572); (R-RNO-5689896); (R-RNO-8948751)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0050821 protein stabilization;GO:0016579 protein deubiquitination;GO:0031669 cellular response to nutrient levels;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A7M3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A7P9-1", "uniprot_id": "D4A7P9_RAT", "mass": 51739.0, "length": 454, "protein_name": "Bone morphogenetic protein 5", "gene_name": "Bmp5", "organism": "Rat", "refseq_name": "bone morphogenetic protein 5 precursor", "refseq_ac": "NP_001101638", "gene_names_uniprotkb": "Bmp5", "gene_names_refseq": "Bmp5", "protein_names_uniprotkb": "Bone morphogenetic protein 5", "protein_names_refseq": "bone morphogenetic protein 5 precursor", "tax_id": 10116, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); Marfan syndrome (Disease Ontology:DOID:14323); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:315824)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17541940;25110111", "class_list": "", "function": "Bmp5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes cartilage matrix synthesis in primary chondrocyte cultures., [RefSeq, PubMed]; Results suggest that BMP5 is widely expressed throughout the adult CNS, and this abundant expression in the adult brain strongly supports the idea that BMP5 plays important roles not only in the developing brain but also in the adult brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031982 vesicle", "go_biological_process": "GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A7P9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A7T9-1", "uniprot_id": "D4A7T9_RAT", "mass": 92745.0, "length": 810, "protein_name": "Deubiquitinase MYSM1", "gene_name": "Mysm1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mysm1", "gene_names_refseq": "", "protein_names_uniprotkb": "Deubiquitinase MYSM1; Myb-like, SWIRM and MPN domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (rno:298247); (R-RNO-5689901)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0042393 histone binding;GO:0140492 metal-dependent deubiquitinase activity;GO:0140950 histone H2A deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030334 regulation of cell migration;GO:0043473 pigmentation;GO:0051797 regulation of hair follicle development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A7T9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A827-1", "uniprot_id": "D4A827_RAT", "mass": 45875.0, "length": 417, "protein_name": "Potassium channel tetramerization domain containing 18", "gene_name": "Kctd18", "organism": "Rat", "refseq_name": "BTB/POZ domain-containing protein KCTD18 isoform 1", "refseq_ac": "NP_001415665", "gene_names_uniprotkb": "Kctd18", "gene_names_refseq": "Kctd18; RGD1564820", "protein_names_uniprotkb": "Potassium channel tetramerization domain containing 18", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD18 isoform 1; BTB/POZ domain-containing protein KCTD18; potassium channel tetramerisation domain containing 18", "tax_id": 10116, "disease": "", "pathway": " (rno:301436)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A827-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A829-1", "uniprot_id": "D4A829_RAT", "mass": 12330.0, "length": 109, "protein_name": "Large ribosomal subunit protein eL43", "gene_name": "Rpl37a-ps5", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rpl37a-ps5", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein eL43; 60S ribosomal protein L37a", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A829-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A831-1", "uniprot_id": "D4A831_RAT", "mass": 171236.0, "length": 1522, "protein_name": "Adhesion G protein-coupled receptor B3", "gene_name": "Adgrb3", "organism": "Rat", "refseq_name": "adhesion G protein-coupled receptor B3", "refseq_ac": "NP_001100368", "gene_names_uniprotkb": "Adgrb3", "gene_names_refseq": "Adgrb3; Bai3", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor B3; Brain-specific angiogenesis inhibitor 3", "protein_names_refseq": "adhesion G protein-coupled receptor B3; brain-specific angiogenesis inhibitor 3", "tax_id": 10116, "disease": "", "pathway": " (rno:301309)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity. Promotes myoblast fusion through ELMO/DOCK1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0043083 synaptic cleft;GO:0098839 postsynaptic density membrane;GO:0150053 cerebellar climbing fiber to Purkinje cell synapse", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0016322 neuron remodeling;GO:0048814 regulation of dendrite morphogenesis;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A831-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A8E7-1", "uniprot_id": "D4A8E7_RAT", "mass": 11991.0, "length": 108, "protein_name": "COMM domain-containing protein 6", "gene_name": "Commd6", "organism": "Rat", "refseq_name": "COMM domain-containing protein 6", "refseq_ac": "NP_001102575", "gene_names_uniprotkb": "Commd6", "gene_names_refseq": "Commd6; RGD1560745", "protein_names_uniprotkb": "COMM domain-containing protein 6", "protein_names_refseq": "COMM domain-containing protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:498559); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A8E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A8F5-1", "uniprot_id": "D4A8F5_RAT", "mass": 45326.0, "length": 401, "protein_name": "AADACL2 family member 2 like 1", "gene_name": "Aadacl2fm2l1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Aadacl2fm2l1; RGD1560162", "gene_names_refseq": "", "protein_names_uniprotkb": "AADACL2 family member 2 like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:502534)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A8F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A8I9-1", "uniprot_id": "D4A8I9_RAT", "mass": 16009.0, "length": 144, "protein_name": "Interleukin 9", "gene_name": "Il9", "organism": "Rat", "refseq_name": "interleukin-9 precursor", "refseq_ac": "NP_001099217", "gene_names_uniprotkb": "Il9", "gene_names_refseq": "Il9", "protein_names_uniprotkb": "Interleukin 9", "protein_names_refseq": "interleukin-9 precursor", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); adult respiratory distress syndrome (Disease Ontology:DOID:11394); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (rno:116558); (R-RNO-8985947)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29359591;29944018", "class_list": "", "function": "Bone marrow mesenchymal stem cells suppress IL-9 in adjuvant-induced arthritis/ Erratum:[Autoimmunity. 2018 Jun;51(4):i. PMID: 29718713], [RefSeq, PubMed]; This study shows that exogenous IL-9 ameliorates experimental autoimmune myasthenia gravis symptoms in rats, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005140 interleukin-9 receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032754 positive regulation of interleukin-5 production;GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0030307 positive regulation of cell growth;GO:0050730 regulation of peptidyl-tyrosine phosphorylation;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A8I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A8N7-1", "uniprot_id": "D4A8N7_RAT", "mass": 77456.0, "length": 689, "protein_name": "Rhophilin-2", "gene_name": "Rhpn2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rhpn2", "gene_names_refseq": "", "protein_names_uniprotkb": "Rhophilin-2; GTP-Rho-binding protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:308516); (R-RNO-5666185); (R-RNO-8980692); (R-RNO-9013026)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0003094 glomerular filtration;GO:0051497 negative regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A8N7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A8Q3-1", "uniprot_id": "D4A8Q3_RAT", "mass": 34651.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or7g12", "organism": "Rat", "refseq_name": "olfactory receptor Olr1125", "refseq_ac": "NP_001000881", "gene_names_uniprotkb": "Or7g12", "gene_names_refseq": "Olr1125; Or7g12", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1125; olfactory receptor Olr1125; olfactory receptor gene Olr1125", "tax_id": 10116, "disease": "", "pathway": " (rno:405180)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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RGD1566320", "gene_names_refseq": "RGD1566320; Smim26", "protein_names_uniprotkb": "Small integral membrane protein 26", "protein_names_refseq": "small integral membrane protein 26", "tax_id": 10116, "disease": "", "pathway": " (rno:296207)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ABV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ABX0-1", "uniprot_id": "D4ABX0_RAT", "mass": 54319.0, "length": 501, "protein_name": "DDB1 and CUL4 associated factor 12-like 1", "gene_name": "Dcaf12l1", "organism": "Rat", "refseq_name": "DDB1- and CUL4-associated factor 12-like protein 1", "refseq_ac": "NP_001101411", "gene_names_uniprotkb": "Dcaf12l1; Dcaf12", "gene_names_refseq": "Dcaf12l1; Dcaf12; RGD1563873; Wdr40b", "protein_names_uniprotkb": "DDB1 and CUL4 associated factor 12-like 1", "protein_names_refseq": "DDB1 and CUL4 associated factor 12; DDB1- and CUL4-associated factor 12-like protein 1; WD repeat domain 40B", "tax_id": 10116, "disease": "", "pathway": " (rno:313296)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ABX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AC15-1", "uniprot_id": "D4AC15_RAT", "mass": 38058.0, "length": 339, "protein_name": "Beta-tectorin", "gene_name": "Tectb", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tectb", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-tectorin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-163125)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AC15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AC20-1", "uniprot_id": "D4AC20_RAT", "mass": 16109.0, "length": 146, "protein_name": "Cytidine deaminase", "gene_name": "Cda", "organism": "Rat", "refseq_name": "cytidine deaminase", "refseq_ac": "NP_001102158", "gene_names_uniprotkb": "Cda", "gene_names_refseq": "Cda", "protein_names_uniprotkb": "Cytidine deaminase; 3.5.4.5; Cytidine aminohydrolase", "protein_names_refseq": "cytidine deaminase", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:362638); (R-RNO-6798695); (R-RNO-73614)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.4;3.5.4.5;5.2.1.8;1.1.1.205;3.2.1.23;2.3.2.5;3.6.4.13;2.4.1.25;3.2.1.33;4.2.99.18;5.6.2.4;4.1.2.4;2.4.1.186;3.5.4.6;3.1.1.47;2.7.1.35;3.4.24.34;3.2.1.17;3.4.22.1;1.11.1.6;2.5.1.18;4.1.2.13;3.6.5.-;4.2.1.24;3.2.1.31;2.4.1.1;2.7.10.2;2.7.11.1;2.7.1.40;1.13.11.-;1.13.11.34;3.4.19.1;2.3.3.8;1.16.3.1;2.7.4.6;2.7.13.3;3.4.23.5;5.4.2.11;5.4.2.4;2.7.1.1;3.3.2.6;3.4.11.4;2.7.1.11;5.3.2.1;5.3.3.12;3.4.21.46;3.1.6.4;2.4.2.7;5.4.2.2;1.1.1.42;3.6.4.6;3.4.24.35;3.1.6.12;2.3.2.26;3.6.4.10;2.7.11.24;3.1.3.48;2.4.2.1;3.4.22.52;3.4.22.27;3.5.1.3;3.4.19.9;2.7.11.39;1.8.3.2;5.3.1.9;5.1.3.-;3.5.1.23;3.5.1.-;3.6.1.6;3.4.25.1;3.4.18.1;1.11.1.24", "go_molecular_function": "GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0001882 nucleoside binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0044206 UMP salvage;GO:0071217 cellular response to external biotic stimulus;GO:0006248 CMP catabolic process;GO:0006249 dCMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AC20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AC99-1", "uniprot_id": "D4AC99_RAT", "mass": 126025.0, "length": 1138, "protein_name": "Chromosome transmission fidelity protein 18 homolog", "gene_name": "Chtf18", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Chtf18", "gene_names_refseq": "", "protein_names_uniprotkb": "Chromosome transmission fidelity protein 18 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287146); (R-RNO-174411)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003689 DNA clamp loader activity;GO:0017116 single-stranded DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031390 Ctf18 RFC-like complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006260 DNA replication;GO:0007140 male meiotic nuclear division;GO:0048468 cell development;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AC99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ACC8-1", "uniprot_id": "D4ACC8_RAT", "mass": 47919.0, "length": 474, "protein_name": "Homeobox even-skipped homolog protein 2", "gene_name": "Evx2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Evx2", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox even-skipped homolog protein 2; EVX-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0035108 limb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ACC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ACL2-1", "uniprot_id": "D4ACL2_RAT", "mass": 57058.0, "length": 512, "protein_name": "Tetratricopeptide repeat protein 38", "gene_name": "Ttc38", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ttc38", "gene_names_refseq": "", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 38", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ACL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ACM1-1", "uniprot_id": "D4ACM1_RAT", "mass": 63171.0, "length": 554, "protein_name": "Elongator complex protein 3", "gene_name": "Elp3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Elp3", "gene_names_refseq": "", "protein_names_uniprotkb": "Elongator complex protein 3; 2.3.1.-", "protein_names_refseq": "", "tax_id": 10116, "disease": "familial dysautonomia (Disease Ontology:DOID:11589)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Not a major acetyltransferase of tubulin. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex., [UniProtKB, UniProtKB, UniProtKB]; Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000049 tRNA binding;GO:0016407 acetyltransferase activity;GO:0106261 tRNA uridine(34) acetyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030335 positive regulation of cell migration;GO:0001764 neuron migration;GO:0007417 central nervous system development;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ACM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ACM8-1", "uniprot_id": "D4ACM8_RAT", "mass": 63765.0, "length": 572, "protein_name": "Frizzled class receptor 7", "gene_name": "Fzd7", "organism": "Rat", "refseq_name": "frizzled-7 precursor", "refseq_ac": "NP_001258114", "gene_names_uniprotkb": "Fzd7", "gene_names_refseq": "Fzd7", "protein_names_uniprotkb": "Frizzled class receptor 7", "protein_names_refseq": "frizzled family receptor 7; frizzled-7 precursor; frizzled-7; rCG22430-like", "tax_id": 10116, "disease": "nephroblastoma (Disease Ontology:DOID:2154)", "pathway": " (rno:100360552); (R-RNO-4086400); (R-RNO-4608870)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005109 frizzled binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0046982 protein heterodimerization activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0071363 cellular response to growth factor stimulus;GO:0034446 substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ACM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ACQ1-1", "uniprot_id": "D4ACQ1_RAT", "mass": 22317.0, "length": 204, "protein_name": "Transmembrane protein 253", "gene_name": "Tmem253", "organism": "Rat", "refseq_name": "transmembrane protein 253", "refseq_ac": "XP_006251981", "gene_names_uniprotkb": "Tmem253", "gene_names_refseq": "Tmem253", "protein_names_uniprotkb": "Transmembrane protein 253", "protein_names_refseq": "transmembrane protein 253", "tax_id": 10116, "disease": "", "pathway": " (rno:690368)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4ACQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AD14-1", "uniprot_id": "D4AD14_RAT", "mass": 97274.0, "length": 855, "protein_name": "Leucine-rich repeat and death domain-containing protein 1", "gene_name": "Lrrd1", "organism": "Rat", "refseq_name": "leucine-rich repeat and death domain-containing protein 1", "refseq_ac": "NP_001425003", "gene_names_uniprotkb": "Lrrd1", "gene_names_refseq": "Lrrd1; RGD1562785", "protein_names_uniprotkb": "Leucine-rich repeat and death domain-containing protein 1", "protein_names_refseq": "leucine-rich repeat and death domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006954 inflammatory response;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4AD14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AD22-1", "uniprot_id": "D4AD22_RAT", "mass": 49809.0, "length": 482, "protein_name": "Otolin 1", "gene_name": "Otol1", "organism": "Rat", "refseq_name": "otolin-1 precursor", "refseq_ac": "NP_001419339", "gene_names_uniprotkb": "Otol1", "gene_names_refseq": "Otol1; 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Lyrm5", "protein_names_uniprotkb": "Electron transfer flavoprotein regulatory factor 1", "protein_names_refseq": "LYR motif containing 5; LYR motif-containing protein 5; electron transfer flavoprotein regulatory factor 1; ghiso", "tax_id": 10116, "disease": "", "pathway": " (rno:100361188)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0090324 negative regulation of oxidative phosphorylation;GO:1901856 negative regulation of cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AD58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AD89-1", "uniprot_id": "D4AD89_RAT", "mass": 104945.0, "length": 964, "protein_name": "Seizure 6-like protein", "gene_name": "Sez6l", "organism": "Rat", "refseq_name": "seizure 6-like protein isoform 2 precursor", "refseq_ac": "NP_001402678", "gene_names_uniprotkb": "Sez6l", "gene_names_refseq": "RGD1563628; 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Regulatory part that prevents formation of the Nlrp1a inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), preventing activation of the Nlrp1a inflammasome. In response to pathogen-associated signals, this part is ubiquitinated by the N-end rule pathway and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the Nlrp1a inflammasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0002221 pattern recognition receptor signaling pathway;GO:0006954 inflammatory response;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4ADT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ADU7-1", "uniprot_id": "D4ADU7_RAT", "mass": 28552.0, "length": 255, "protein_name": "EEF1A lysine methyltransferase 4", "gene_name": "Eef1akmt4", "organism": "Rat", "refseq_name": "EEF1A lysine methyltransferase 4", "refseq_ac": "NP_001386379", "gene_names_uniprotkb": "Eef1akmt4; LOC102551435", "gene_names_refseq": "Eef1akmt4", "protein_names_uniprotkb": "EEF1A lysine methyltransferase 4", "protein_names_refseq": "EEF1A lysine methyltransferase 4; endothelin-converting enzyme 2-like; endothelin-converting enzyme 2", "tax_id": 10116, "disease": "", "pathway": " (rno:102551435)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.361;2.1.1.359;2.1.1.-;2.1.1.355;2.1.1.354;2.1.1.362", "go_molecular_function": "GO:0008168 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ADU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AE36-1", "uniprot_id": "D4AE36_RAT", "mass": 11000.0, "length": 101, "protein_name": "Prostate and testis expressed 14", "gene_name": "Pate14", "organism": "Rat", "refseq_name": "prostate and testis expressed 14 precursor", "refseq_ac": "NP_001244023", "gene_names_uniprotkb": "Pate14; LOC100359968", "gene_names_refseq": "Pate-Q; Pate14", "protein_names_uniprotkb": "Prostate and testis expressed 14", "protein_names_refseq": "Secreted seminal-vesicle Ly-6 protein 1-like; prostate and testis expressed 14 precursor; prostate and testis expressed protein Q; rCG64165-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100359968)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "H8Y6J2", "ec_number_list": "", "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AE36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AE56-1", "uniprot_id": "D4AE56_RAT", "mass": 44471.0, "length": 392, "protein_name": "Prostaglandin E synthase 2", "gene_name": "Ptges2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ptges2", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostaglandin E synthase 2; 5.3.99.3; Microsomal prostaglandin E synthase 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:311865); (R-RNO-2162123); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.2.2;3.4.21.4;3.4.16.-;3.2.1.-;5.3.4.1;5.3.99.3;2.5.1.18;1.1.1.205;3.2.1.23;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.17;3.2.1.31;3.5.3.1;2.7.11.13;2.3.3.8;3.2.1.51;3.4.21.20;1.6.2.2;3.5.3.15;3.5.1.26;3.6.4.6;4.2.1.152;5.3.99.5;3.1.6.12;2.4.1.1;2.7.11.24;3.1.27.-;3.4.14.1;3.1.6.4;3.1.6.8;1.6.5.5;3.6.1.-;2.7.10.2;3.4.19.9;3.1.3.16;3.2.1.52;6.3.4.21;3.4.14.2;1.11.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0016829 lyase activity;GO:0050220 prostaglandin-E synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0019371 cyclooxygenase pathway;GO:0046903 secretion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4AE56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AE80-1", "uniprot_id": "D4AE80_RAT", "mass": 65178.0, "length": 601, "protein_name": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase", "gene_name": "Dcp1a", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dcp1a", "gene_names_refseq": "", "protein_names_uniprotkb": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase; 3.6.1.62", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:361109); (R-RNO-430039); (R-RNO-450385); (R-RNO-450513); (R-RNO-975957)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.1.62;2.7.11.1;3.6.4.13;3.1.-.-;3.1.13.-;3.6.1.64;4.2.99.18;3.1.3.16;2.7.11.22;3.6.1.59;3.6.1.52;3.6.1.10;3.6.1.61", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding;GO:0019894 kinesin binding;GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:1903608 protein localization to cytoplasmic stress granule;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA;GO:0110156 mRNA methylguanosine-cap decapping", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4AE80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AED2-1", "uniprot_id": "D4AED2_RAT", "mass": 29696.0, "length": 262, "protein_name": "DET1- and DDB1-associated protein 1", "gene_name": "Dda1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dda1", "gene_names_refseq": "", "protein_names_uniprotkb": "DET1- and DDB1-associated protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-8951664)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4AED2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AEG7-1", "uniprot_id": "D4AEG7_RAT", "mass": 46477.0, "length": 400, "protein_name": "TBC1 domain family member 13", "gene_name": "Tbc1d13", "organism": "Rat", "refseq_name": "TBC1 domain family member 13", "refseq_ac": "NP_001386383", "gene_names_uniprotkb": "Tbc1d13", "gene_names_refseq": "Tbc1d13", "protein_names_uniprotkb": "TBC1 domain family member 13", "protein_names_refseq": "TBC1 domain family member 13", "tax_id": 10116, "disease": "", "pathway": " (rno:499768); (R-RNO-8854214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AEG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AEP0-1", "uniprot_id": "D4AEP0_RAT", "mass": 50085.0, "length": 456, "protein_name": "Adenylosuccinate synthetase isozyme 2", "gene_name": "Adss2", "organism": "Rat", "refseq_name": "adenylosuccinate synthetase isozyme 2", "refseq_ac": "NP_001099445", "gene_names_uniprotkb": "Adss2; ADSS2; ADSS; Adss", "gene_names_refseq": "Adss2; Adss", "protein_names_uniprotkb": "Adenylosuccinate synthetase isozyme 2; 6.3.4.4; AMPSase 2; AdSS 2; Adenylosuccinate synthetase, acidic isozyme; Adenylosuccinate synthetase, liver isozyme; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase", "protein_names_refseq": "adenylosuccinate synthetase 2, non muscle; adenylosuccinate synthetase isozyme 2; adenylosuccinate synthetase, non muscle", "tax_id": 10116, "disease": "sarcoma (Disease Ontology:DOID:1115)", "pathway": " (rno:289276); (R-RNO-73817)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP., [UniProtKB, HAMAP, UniProtKB, UniProtKB, HAMAP, UniProtKB]; Plays an important role in the de novo pathway of purine nucleotide biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.3.4.4", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0004019 adenylosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0014074 response to purine-containing compound;GO:0046040 IMP metabolic process;GO:0006531 aspartate metabolic process;GO:0044209 AMP salvage;GO:0071257 cellular response to electrical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4AEP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PSL8-1", "uniprot_id": "E9PSL8_RAT", "mass": 90441.0, "length": 802, "protein_name": "Kinesin-like protein", "gene_name": "Kif6", "organism": "Rat", "refseq_name": "kinesin-like protein KIF6", "refseq_ac": "NP_001418110", "gene_names_uniprotkb": "Kif6", "gene_names_refseq": "Kif6; Krp3", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-like protein KIF6; kinesin-related protein 3", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); idiopathic scoliosis (Disease Ontology:DOID:0060250); aortic dissection (Disease Ontology:DOID:0080685); hypertension (Disease Ontology:DOID:10763); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:171291); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "11870094", "class_list": "", "function": "Findings suggest a possible role for KRP3 motor isoforms in spermatid maturation mediated by possible interaction with the Ran GTPase, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0001673 male germ cell nucleus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PSL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZEQ5-1", "uniprot_id": "D3ZEQ5_RAT", "mass": 97893.0, "length": 853, "protein_name": "Vomeronasal 2 receptor, pseudogene 67", "gene_name": "Vom2r-ps67; Vom2r42l1; Vom2r42", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Vom2r-ps67; Vom2r42l1; Vom2r42; Vom2r40; Vom2r42l1; Vom2r42", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal 2 receptor, pseudogene 67", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:679557)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZEQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2K5W1-1", "uniprot_id": "A0A0G2K5W1_RAT", "mass": 146763.0, "length": 1405, "protein_name": "NCK-associated protein 5-like", "gene_name": "Nckap5l", "organism": "Rat", "refseq_name": "nck-associated protein 5-like isoform X1", "refseq_ac": "XP_038935254", "gene_names_uniprotkb": "Nckap5l", "gene_names_refseq": "Nckap5l; RGD1561571", "protein_names_uniprotkb": "NCK-associated protein 5-like", "protein_names_refseq": "nck-associated protein 5-like isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:315297)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0007019 microtubule depolymerization;GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K5W1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AB17-1", "uniprot_id": "D4AB17_RAT", "mass": 144392.0, "length": 1337, "protein_name": "Phosphoribosylformylglycinamidine synthase", "gene_name": "Pfas", "organism": "Rat", "refseq_name": "phosphoribosylformylglycinamidine synthase", "refseq_ac": "NP_001382026", "gene_names_uniprotkb": "Pfas", "gene_names_refseq": "Pfas", "protein_names_uniprotkb": "Phosphoribosylformylglycinamidine synthase; 6.3.5.3; Formylglycinamide ribonucleotide amidotransferase; Formylglycinamide ribotide amidotransferase", "protein_names_refseq": "FGAM synthetase; phosphoribosylformylglycinamidine synthase (FGAR amidotransferase); phosphoribosylformylglycinamidine synthase", "tax_id": 10116, "disease": "colon adenocarcinoma (Disease Ontology:DOID:234); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:287420); (R-RNO-73817)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29337348", "class_list": "", "function": "Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate., [UniProtKB, UniProtKB]; Study observed FGAMS as distinct puncta throughout neuronal processes, where it co-localized with neurofilament heavy chain, tubulin, and mitochondria. Data provide insight into potential purine biosynthetic mechanisms utilized within neurons during homeostasis as well as viral infection., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.3.5.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004642 phosphoribosylformylglycinamidine synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009410 response to xenobiotic stimulus;GO:0006541 glutamine metabolic process;GO:0006177 GMP biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4AB17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZAQ5-1", "uniprot_id": "CP086_RAT", "mass": 32097.0, "length": 306, "protein_name": "Uncharacterized protein C16orf86 homolog", "gene_name": "C19h16orf86", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "C19h16orf86; RGD1561415", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein C16orf86 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:498943)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZAQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0JPM9-1", "uniprot_id": "EIF3J_RAT", "mass": 29187.0, "length": 259, "protein_name": "Eukaryotic translation initiation factor 3 subunit J", "gene_name": "Eif3j", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 3 subunit J", "refseq_ac": "NP_001071138", "gene_names_uniprotkb": "Eif3j; EIF3J; EIF3S1; Eif3s1", "gene_names_refseq": "Eif3j; Eif3s1; eIF3 p35", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit J; Eukaryotic translation initiation factor 3 subunit 1; eIF-3-alpha; eIF3 p35; eIF3j", "protein_names_refseq": "eIF-3-alpha; eukaryotic translation initiation factor 3 subunit 1; eukaryotic translation initiation factor 3 subunit J; eukaryotic translation initiation factor 3, subunit 1 alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:691947); (R-RNO-156827); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "22025682;22673903", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA., [UniProtKB, HAMAP, UniProtKB, UniProtKB]; Knockdown of eIF-3-alpha enhances the expression of differentiation markers in PC12 cell., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0JPM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5DFC8-1", "uniprot_id": "EIF3C_RAT", "mass": 105435.0, "length": 911, "protein_name": "Eukaryotic translation initiation factor 3 subunit C", "gene_name": "Eif3c", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 3 subunit C", "refseq_ac": "NP_001094132", "gene_names_uniprotkb": "Eif3c; EIF3C; EIF3S8; Eif3s8", "gene_names_refseq": "Eif3c; Eif3s8; eIF3 p110", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit C; Eukaryotic translation initiation factor 3 subunit 8; eIF3 p110; eIF3c", "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit 8; eukaryotic translation initiation factor 3 subunit C; eukaryotic translation initiation factor 3, subunit 8, 110kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:293484); (R-RNO-156827); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3MIB2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0045727 positive regulation of translation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B5DFC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70534-1", "uniprot_id": "DLK1_RAT", "mass": 41149.0, "length": 383, "protein_name": "Protein delta homolog 1", "gene_name": "Dlk1", "organism": "Rat", "refseq_name": "protein delta homolog 1 precursor", "refseq_ac": "NP_446196", "gene_names_uniprotkb": "Dlk1; Dlk; Pref1; Zog", "gene_names_refseq": "DLK-1; Dlk1; Pref-1; Zog", "protein_names_uniprotkb": "Protein delta homolog 1; DLK-1; Preadipocyte factor 1; Pref-1", "protein_names_refseq": "delta-like 1 homolog; preadipocyte factor 1; protein delta homolog 1 precursor; protein delta homolog 1", "tax_id": 10116, "disease": "biliary atresia (Disease Ontology:DOID:13608); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (rno:114587)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12655782;22128169;29453913;30145985;31091532;33472171;35050550;9275085;9645708", "class_list": "", "function": "Adipocyte progenitor cells are involved in the rat mesenteric lymph node (MLN) development through differentiation into fibroblastic reticular cells or follicular dendritic cells; expression of the relevant chemokines during the development of MLNs is dynamic and may be related to the maintenance of lymph nodes self-balance state., [RefSeq, PubMed]; Decreased Dlk1 expression relates to visceral fat expansion and insulin resistance in a rat model of catch-up growth following prenatal growth restriction Erratum:[Pediatr Res. 2024 Jan;95(1):406. doi: 10.1038/s41390-023-02691-2. PMID: 37316710], [RefSeq, PubMed]; Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors., [RefSeq, PubMed]; Localisation in rat was in the medulla and the zona glomerulosa of the cortex of the adrenal glands, in the pars distalis of the adenohypophysis, and in the ovarian granulosa lutein cells but no staining was found in the pancreas, [RefSeq, PubMed]; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Neither of the two doses of FLX has significantly affected the Pref-1 expression in any type of adipose tissue., [RefSeq, PubMed]; The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62779", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0035264 multicellular organism growth;GO:0045780 positive regulation of bone resorption;GO:0001819 positive regulation of cytokine production;GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O70534-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A7V9-1", "uniprot_id": "E2AK4_RAT", "mass": 186724.0, "length": 1649, "protein_name": "eIF-2-alpha kinase GCN2", "gene_name": "Eif2ak4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Eif2ak4; Gcn2", "gene_names_refseq": "", "protein_names_uniprotkb": "eIF-2-alpha kinase GCN2; 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "pulmonary venoocclusive disease 2 (Disease Ontology:DOID:0081269); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:114859)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15051816;15774759;29393594", "class_list": "", "function": "Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (By similarity). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (By similarity). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a role in feeding behavior to maintain amino acid homeostasis; contributes to the innate aversion toward diets of imbalanced amino acid composition (PubMed:15051816, PubMed:15774759). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070417 cellular response to cold;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0007612 learning;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4A7V9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35303-1", "uniprot_id": "DNM1L_RAT", "mass": 83908.0, "length": 755, "protein_name": "Dynamin-1-like protein", "gene_name": "Dnm1l", "organism": "Rat", "refseq_name": "dynamin-1-like protein isoform 1", "refseq_ac": "NP_446107", "gene_names_uniprotkb": "Dnm1l; Dlp1; Drp1", "gene_names_refseq": "DLP1; Dnm1l; Dnml1; Drp1", "protein_names_uniprotkb": "Dynamin-1-like protein; 3.6.5.5; Dynamin-like protein", "protein_names_refseq": "C-terminal region; N-terminal region; dynamin-1-like protein isoform 1; dynamin-1-like protein; dynamin-like protein 1; dynamin-related protein 1", "tax_id": 10116, "disease": "encephalopathy due to defective mitochondrial and peroxisomal fission 1 (Disease Ontology:DOID:0070347); optic atrophy 5 (Disease Ontology:DOID:0111438); Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930); dental fluorosis (Disease Ontology:DOID:13711); Parkinson's disease (Disease Ontology:DOID:14330); pulmonary fibrosis (Disease Ontology:DOID:3770); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:114114); (R-RNO-75153)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10679301;11553726;12499366;12861026;17301055;18250306;18683930;22673903;22745122;23014793;23792689;28463107;33422108;34764359;38266577;38504290;38733520;38850669;39285628;9472031", "class_list": "", "function": "A partial Drp1 knockout improves autophagy flux independent of mitochondrial function. Publication Status: Online-Only, [RefSeq, PubMed]; AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission., [RefSeq, PubMed]; ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated Mitochondrial Dynamic., [RefSeq, PubMed]; Functions in mitochondrial and peroxisomal division (PubMed:11553726, PubMed:12499366, PubMed:12861026, PubMed:17301055, PubMed:18250306). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:11553726). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (By similarity). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (By similarity). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner. Plays an important role in mitochondrial fission during mitosis (By similarity). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (By similarity). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:18250306, PubMed:23792689). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:18250306, PubMed:23792689). Required for programmed necrosis execution (By similarity). Rhythmic control of its activity following phosphorylation at Ser-656 is essential for the circadian control of mitochondrial ATP production (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation., [RefSeq, PubMed]; STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related protein 1) controlled-mitochondrial fission during the development of apoptotic-resistance in pulmonary arterial endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35318;O35319;O35320;O35321;O35322;O35323;Q5U2W1;Q792T7;Q9R234;Q9R277", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0051433 BH2 domain binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0098835 presynaptic endocytic zone membrane;GO:0099073 mitochondrion-derived vesicle;GO:0000139 Golgi membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0036466 synaptic vesicle recycling via endosome;GO:0070585 protein localization to mitochondrion;GO:0090149 mitochondrial membrane fission;GO:1900063 regulation of peroxisome organization;GO:1900244 positive regulation of synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "O35303-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RYG7-1", "uniprot_id": "DOK3_RAT", "mass": 48190.0, "length": 444, "protein_name": "Docking protein 3", "gene_name": "Dok3", "organism": "Rat", "refseq_name": "docking protein 3", "refseq_ac": "NP_001100806", "gene_names_uniprotkb": "Dok3", "gene_names_refseq": "Dok3", "protein_names_uniprotkb": "Docking protein 3; Downstream of tyrosine kinase 3", "protein_names_refseq": "docking protein 3; downstream of tyrosine kinase 3", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (rno:306760); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B2RYG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZQF4-1", "uniprot_id": "FKBP6_RAT", "mass": 37455.0, "length": 327, "protein_name": "Inactive peptidyl-prolyl cis-trans isomerase FKBP6", "gene_name": "Fkbp6", "organism": "Rat", "refseq_name": "inactive peptidyl-prolyl cis-trans isomerase FKBP6", "refseq_ac": "NP_001099392", "gene_names_uniprotkb": "Fkbp6; As; Fkbp36", "gene_names_refseq": "FKBP-36; Fkbp6; PPiase", "protein_names_uniprotkb": "Inactive peptidyl-prolyl cis-trans isomerase FKBP6; 36 kDa FK506-binding protein; FK506-binding protein 6; Immunophilin FKBP36; Inactive PPIase FKBP6", "protein_names_refseq": "36 kDa FK506 binding protein; FK506 binding protein 6, 36kDa; FK506-binding protein 6; FKBP prolyl isomerase 6; immunophilin FKBP36; inactive PPIase FKBP6; inactive peptidyl-prolyl cis-trans isomerase FKBP6; peptidyl-prolyl cis-trans isomerase FKBP6; rotamase", "tax_id": 10116, "disease": "spermatogenic failure 77 (Disease Ontology:DOID:0070576); male infertility (Disease Ontology:DOID:12336); Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (rno:288597)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12764197;18408354", "class_list": "", "function": "Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes., [UniProtKB, UniProtKB, UniProtKB]; Fkbp6 is a component of the synaptonemal complex essential for sex-specific fertility and for the fidelity of homologous chromosome pairing in meiosis., [RefSeq, PubMed]; Fundamental role of Fkbp6 in homologous chromosome synapsis during male meiosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051879 Hsp90 protein binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006457 protein folding;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZQF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55171-1", "uniprot_id": "ACOT2_RAT", "mass": 49701.0, "length": 453, "protein_name": "Acyl-coenzyme A thioesterase 2, mitochondrial", "gene_name": "Acot2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Acot2; Mte1", "gene_names_refseq": "", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 2, mitochondrial; 3.1.2.2; ARTISt/p43; Acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterase 2; MTE-I; Very-long-chain acyl-CoA thioesterase", "protein_names_refseq": "", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-RNO-77289); (R-RNO-9033241); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "34502162;7744868;9445388;9703974", "class_list": "", "function": "Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (By similarity). Displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:7744868). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88268", "ec_number_list": "6.1.1.5;1.3.8.5;6.2.1.4;4.98.1.1;5.6.2.3;1.1.3.15;1.2.3.5;3.4.21.-;2.8.3.5;2.3.1.-;3.1.2.2;2.3.2.27;1.4.3.1;3.5.2.6;2.3.1.41;3.4.21.92;3.5.3.1;1.4.3.3;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.2.-;1.1.1.37;1.11.1.6;6.4.1.3;1.3.3.6;3.1.2.14;2.6.1.51;2.6.1.44;7.1.2.2;1.4.1.3;2.3.1.137;1.2.1.3;2.3.1.176;2.3.1.16;2.3.1.155;2.3.1.37;3.1.2.1;2.3.1.9;4.2.1.2;2.3.3.10;5.3.3.8;2.3.2.36;2.5.1.18;1.1.1.30;3.4.24.56;1.1.1.42;3.1.2.22;3.6.4.10;1.2.4.1;5.6.1.7;5.1.99.4;1.3.8.1;4.1.3.4;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.1.4;3.1.1.5;1.14.13.39;2.7.1.23;3.4.21.53;1.2.4.2;5.3.3.21;2.7.11.2;2.7.11.-;3.1.2.27;2.3.1.65;7.1.1.2;1.2.1.36;1.7.1.-;1.2.1.28;3.6.1.-;3.6.1.77;1.8.1.4;2.3.1.7;4.1.2.63;2.3.3.1;3.1.2.11;3.1.2.3;3.1.2.5;1.1.1.300;1.1.1.184;4.1.1.9;1.1.1.41;4.2.1.3;2.3.1.42;1.3.1.38;2.7.4.6;1.3.1.124", "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0016790 thiolester hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55171-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RYE5-1", "uniprot_id": "E41LB_RAT", "mass": 59571.0, "length": 527, "protein_name": "Band 4.1-like protein 4B", "gene_name": "Epb41l4b", "organism": "Rat", "refseq_name": "band 4.1-like protein 4B isoform 2", "refseq_ac": "NP_001121037", "gene_names_uniprotkb": "Epb41l4b; Lulu2", "gene_names_refseq": "Epb41l4b; RGD1562988", "protein_names_uniprotkb": "Band 4.1-like protein 4B; Erythrocyte membrane protein band 4.1-like 4B", "protein_names_refseq": "band 4.1-like protein 4B isoform 2; band 4.1-like protein 4B", "tax_id": 10116, "disease": "", "pathway": " (rno:500464)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18. Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing. May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0045177 apical part of cell", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0045785 positive regulation of cell adhesion;GO:0051549 positive regulation of keratinocyte migration;GO:0031032 actomyosin structure organization;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02528-1", "uniprot_id": "CRGE_RAT", "mass": 21264.0, "length": 174, "protein_name": "Gamma-crystallin E", "gene_name": "Cryga; Cryge", "organism": "Rat", "refseq_name": "gamma-crystallin E", "refseq_ac": "NP_775411", "gene_names_uniprotkb": "Cryga; Cryge; Cryga", "gene_names_refseq": "Cryg5; Cryge; Len", "protein_names_uniprotkb": "Gamma-crystallin E; Gamma-2; Gamma-E-crystallin; Gamma-crystallin 3-1", "protein_names_refseq": "Crystallin, gamma polypeptide 5; gamma-2; gamma-E-crystallin; gamma-crystallin 3-1; gamma-crystallin D-like; gamma-crystallin E", "tax_id": 10116, "disease": "cataract 4 multiple types (Disease Ontology:DOID:0110234); cataract 7 (Disease Ontology:DOID:0110260); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:24279)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "26385181;27517863;2777080;6294661;6319707;9367641", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Specific oxidation sites of methionine, cysteine and tryptophan in water-soluble and -insoluble gammaE and gammaF-crystallin were determined by one-shot analysis after low-dose gamma-irradiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P02528-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00689-1", "uniprot_id": "AMYP_RAT", "mass": 57177.0, "length": 508, "protein_name": "Pancreatic alpha-amylase", "gene_name": "Amy2a3; Amy2", "organism": "Rat", "refseq_name": "pancreatic alpha-amylase precursor", "refseq_ac": "NP_113690", "gene_names_uniprotkb": "Amy2a3; Amy2; Amy2a1; LOC103689940", "gene_names_refseq": "Amy2a3; Amy2", "protein_names_uniprotkb": "Pancreatic alpha-amylase; 1,4-alpha-D-glucan glucanohydrolase; 3.2.1.1; PA", "protein_names_refseq": "1,4-alpha-D-glucan glucanohydrolase; PA; amylase 2, pancreatic; pancreatic alpha-amylase precursor; pancreatic alpha-amylase-like; pancreatic alpha-amylase; pancreatic amylase", "tax_id": 10116, "disease": "", "pathway": " (rno:497039); (R-RNO-189085)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17980695;20981735;6159531;6168351", "class_list": "glycogene;glycosylhydrolase", "function": "Analysis of how amylase secretion is proteoglycan-dependent in rat parotid acinar cells, [RefSeq, PubMed]; Comparative proteomic analysis revealed that amylase levels were decreased by twofold in pancreases from hyperlipidemic rats compared with control rats.Pancreatic amylase protein levels were also decreased in tissue from hyperlipidemic rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.1.1", "go_molecular_function": "GO:0016160 amylase activity;GO:0031404 chloride ion binding;GO:0005509 calcium ion binding;GO:0004556 alpha-amylase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0016052 carbohydrate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P00689-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35779-1", "uniprot_id": "BHE41_RAT", "mass": 43917.0, "length": 410, "protein_name": "Class E basic helix-loop-helix protein 41", "gene_name": "Bhlhb3; Bhlhe41", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Bhlhb3; Bhlhe41; Sharp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Class E basic helix-loop-helix protein 41; Class B basic helix-loop-helix protein 3; Enhancer-of-split and hairy-related protein 1; SHARP-1; bHLHb3; bHLHe41", "protein_names_refseq": "", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); lung adenocarcinoma (Disease Ontology:DOID:3910); esophageal cancer (Disease Ontology:DOID:5041)", "pathway": " (rno:117095)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12397359;9532582", "class_list": "", "function": "Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity (By similarity). Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 and CYP3A11 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0045892 negative regulation of DNA-templated transcription;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35779-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54952-1", "uniprot_id": "BRCA1_RAT", "mass": 199879.0, "length": 1817, "protein_name": "Breast cancer type 1 susceptibility protein homolog", "gene_name": "Brca1", "organism": "Rat", "refseq_name": "breast cancer type 1 susceptibility protein homolog", "refseq_ac": "NP_036646", "gene_names_uniprotkb": "Brca1", "gene_names_refseq": "BRCA-1; Brca1", "protein_names_uniprotkb": "Breast cancer type 1 susceptibility protein homolog; 2.3.2.27; RING-type E3 ubiquitin transferase BRCA1", "protein_names_refseq": "RING-type E3 ubiquitin transferase BRCA1; breast cancer 1, early onset; breast cancer type 1 susceptibility protein homolog", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); Fanconi anemia complementation group S (Disease Ontology:DOID:0060979); multiple epiphyseal dysplasia 2 (Disease Ontology:DOID:0070298); Stickler syndrome (Disease Ontology:DOID:0080046); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); osteochondrodysplasia (Disease Ontology:DOID:2256); ovarian cancer (Disease Ontology:DOID:2394); breast adenocarcinoma (Disease Ontology:DOID:3458); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); stomach carcinoma (Disease Ontology:DOID:5517); hereditary breast ovarian cancer syndrome (Disease Ontology:DOID:5683); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:497672); (R-RNO-3108214); (R-RNO-5685938); (R-RNO-5685942); (R-RNO-5689901); (R-RNO-5693537); (R-RNO-5693565); (R-RNO-5693568); (R-RNO-5693571); (R-RNO-5693579); (R-RNO-5693607); (R-RNO-5693616); (R-RNO-6804756); (R-RNO-69473)", "pathway_count": 14, "publication_count": 5, "publication_id_list": "11877378;28585187;29498408;8761410;9892727", "class_list": "", "function": "BRCA1 offers prominent functional roles in neurons and glial cells including key support for their physical and molecular integrity., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study indicates that alterations in the localization of BRCA1 protein occur in preneoplastic lesions of the DMBA-rat model of mammary gland carcinogenesis. While no change in the level of BRCA1 protein was detected, its translocation from the cytoplasm to nucleus is blocked during breast cancer progression., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P97951", "ec_number_list": "5.6.2.3;2.3.2.26;2.7.7.7;3.1.-.-;2.7.11.1;3.4.19.-;2.3.2.27;3.4.19.12;5.6.2.4;5.6.2.1;2.1.1.357;3.1.11.-;2.3.2.-;3.1.22.-;3.6.4.-;2.7.11.17;2.4.99.18;2.3.1.48;2.3.1.-;2.3.2.23;6.5.1.1;3.6.-.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0060816 random inactivation of X chromosome;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54952-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88201-1", "uniprot_id": "CLC11_RAT", "mass": 36388.0, "length": 328, "protein_name": "C-type lectin domain family 11 member A", "gene_name": "Clec11a", "organism": "Rat", "refseq_name": "C-type lectin domain family 11 member A precursor", "refseq_ac": "NP_001012477", "gene_names_uniprotkb": "Clec11a; Scgf", "gene_names_refseq": "Clec11a; Scgf", "protein_names_uniprotkb": "C-type lectin domain family 11 member A; Lymphocyte secreted C-type lectin; Osteolectin; Stem cell growth factor", "protein_names_refseq": "C-type lectin domain family 11 member A precursor; C-type lectin domain family 11, member A; lymphocyte secreted C-type lectin; osteolectin; stem cell growth factor", "tax_id": 10116, "disease": "", "pathway": " (rno:29313)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12048244;15234225;9705843", "class_list": "", "function": "Dramatic increase in c-kit expression observed in the rat carotid artery after balloon injury suggests SCF/c-kit signaling may affect smooth muscle cell function via an autocrine pathway., [RefSeq, PubMed]; Negative feedback with kit ligand (Scgf) and oocyte BMP15 regulated granulosa cell mitosis, [RefSeq, PubMed]; Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EAN4", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88201-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A4KWA6-1", "uniprot_id": "CL2D3_RAT", "mass": 27807.0, "length": 252, "protein_name": "C-type lectin domain family 2 member D3", "gene_name": "Clec2d2l1; Clec2d3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Clec2d2l1; Clec2d3; LOC689757", "gene_names_refseq": "", "protein_names_uniprotkb": "C-type lectin domain family 2 member D3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "17462921", "class_list": "", "function": "Lectin-type cell surface receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4KWA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88656-1", "uniprot_id": "ARC1B_RAT", "mass": 41057.0, "length": 372, "protein_name": "Actin-related protein 2/3 complex subunit 1B", "gene_name": "Arpc1b", "organism": "Rat", "refseq_name": "actin-related protein 2/3 complex subunit 1B", "refseq_ac": "NP_062162", "gene_names_uniprotkb": "Arpc1b", "gene_names_refseq": "Arpc1b; p41Arc", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 1B; Arp2/3 complex 41 kDa subunit; p41-ARC", "protein_names_refseq": "Actin-related protein complex 1b; actin-related protein 2/3 complex subunit 1B; arp2/3 complex 41 kDa subunit; p41-ARC", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); immunodeficiency 71 (Disease Ontology:DOID:0112004); stomach cancer (Disease Ontology:DOID:10534); gastritis (Disease Ontology:DOID:4029); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:54227); (R-RNO-2029482); (R-RNO-3928662); (R-RNO-5663213)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "22673903;27113856;28242260;28972183", "class_list": "", "function": "Arpc1b knockdown in adult rat testis led to defects in spermiation caused by failure in Sertoli-cell tubulobulbar complexes formation. Knockdown also compromised blood-testis barrier integrity and caused polarity defects of mature spermatids. Arpc1b reduction perturbed ability of germ cells to enter G2/M phase thus hindering cell division., [RefSeq, PubMed]; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that expression of spermiation-related genes is directly up-regulated by estrogen 17-beta-estradiol in testes of adult rats; a functional estrogen response element lies upstream of Arpc1b and Evl genes. (Arpc1b = actin related protein 2-3 complex, subunit 1B; Evl = enabled-VASP-like protein), [RefSeq, PubMed]; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks., [UniProtKB, UniProtKB]; These results expand the model of insulin-stimulated glucose uptake in skeletal muscle cells by implicating p41ARC as a new component of the insulin-signaling cascade and connecting PAK1 signaling to N-WASP-cortactin-mediated actin polymerization and GLUT4 vesicle translocation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding;GO:0044877 protein-containing complex binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005885 Arp2/3 protein complex;GO:0036284 tubulobulbar complex", "go_biological_process": "GO:0032355 response to estradiol;GO:0043627 response to estrogen;GO:0034314 Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88656-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1M754-1", "uniprot_id": "F1M754_RAT", "mass": 150744.0, "length": 1318, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Map4k4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Map4k4", "gene_names_refseq": "", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); epilepsy (Disease Ontology:DOID:1826); hepatitis B (Disease Ontology:DOID:2043); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-2559580)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004111 creatine kinase activity;GO:0008017 microtubule binding;GO:0008349 MAP kinase kinase kinase kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005925 focal adhesion", "go_biological_process": "GO:0000165 MAPK cascade;GO:0048812 neuron projection morphogenesis;GO:0043408 regulation of MAPK cascade;GO:0006468 protein phosphorylation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1M754-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R8P3-1", "uniprot_id": "M0R8P3_RAT", "mass": 43045.0, "length": 400, "protein_name": "Calcium-binding tyrosine phosphorylation-regulated protein", "gene_name": "Cabyr", "organism": "Rat", "refseq_name": "calcium-binding tyrosine phosphorylation-regulated protein", "refseq_ac": "NP_001137365", "gene_names_uniprotkb": "Cabyr", "gene_names_refseq": "Cabyr", "protein_names_uniprotkb": "Calcium-binding tyrosine phosphorylation-regulated protein", "protein_names_refseq": "calcium binding tyrosine-(Y)-phosphorylation regulated; calcium-binding tyrosine phosphorylation-regulated protein; calcium-binding tyrosine-phosphorylation regulated protein", "tax_id": 10116, "disease": "male infertility (Disease Ontology:DOID:12336)", "pathway": " (rno:686189)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0035686 sperm fibrous sheath;GO:0097229 sperm end piece;GO:0005654 nucleoplasm", "go_biological_process": "GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0R8P3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LQ91-1", "uniprot_id": "F1LQ91_RAT", "mass": 237812.0, "length": 2073, "protein_name": "Dedicator of cytokinesis 11", "gene_name": "Dock11", "organism": "Rat", "refseq_name": "dedicator of cytokinesis protein 11 isoform 1", "refseq_ac": "NP_001178689", "gene_names_uniprotkb": "Dock11", "gene_names_refseq": "Dock11", "protein_names_uniprotkb": "Dedicator of cytokinesis 11", "protein_names_refseq": "dedicator of cytokinesis protein 11 isoform 1; dedicator of cytokinesis protein 11", "tax_id": 10116, "disease": "", "pathway": " (rno:313438); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-983231)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0051491 positive regulation of filopodium assembly;GO:0001782 B cell homeostasis;GO:0002315 marginal zone B cell differentiation;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1LQ91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LQF5-1", "uniprot_id": "F1LQF5_RAT", "mass": 39118.0, "length": 345, "protein_name": "Ubiquitin-associated domain-containing protein 2", "gene_name": "Ubac2", "organism": "Rat", "refseq_name": "ubiquitin-associated domain-containing protein 2", "refseq_ac": "NP_001030109", "gene_names_uniprotkb": "Ubac2", "gene_names_refseq": "Phgdhl1; Ubac2", "protein_names_uniprotkb": "Ubiquitin-associated domain-containing protein 2; Phosphoglycerate dehydrogenase-like protein 1", "protein_names_refseq": "phosphoglycerate dehydrogenase like 1; ubiquitin-associated domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361094)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0070972 protein localization to endoplasmic reticulum;GO:1904153 negative regulation of retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LQF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LSV0-1", "uniprot_id": "F1LSV0_RAT", "mass": 104324.0, "length": 954, "protein_name": "Semaphorin-4B", "gene_name": "Sema4b", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sema4b", "gene_names_refseq": "", "protein_names_uniprotkb": "Semaphorin-4B; Semaphorin-C", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:293042)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0016020 membrane;GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0120035 regulation of plasma membrane bounded cell projection organization;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LSV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1MAQ4-1", "uniprot_id": "F1MAQ4_RAT", "mass": 141662.0, "length": 1259, "protein_name": "Trafficking protein particle complex subunit 10", "gene_name": "Trappc10", "organism": "Rat", "refseq_name": "trafficking protein particle complex subunit 10", "refseq_ac": "NP_001166999", "gene_names_uniprotkb": "Trappc10", "gene_names_refseq": "Tmem1; 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Ellis van Creveld protein; Ellis van Creveld syndrome homolog; Ellis van Creveld syndrome protein; ellis-van Creveld syndrome protein homolog; evC complex member EVC", "tax_id": 10116, "disease": "Weyers acrofacial dysostosis (Disease Ontology:DOID:0111571); Ellis-Van Creveld syndrome (Disease Ontology:DOID:12714); ventricular septal defect (Disease Ontology:DOID:1657)", "pathway": " (rno:289712); (R-RNO-5632684)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15278943", "class_list": "", "function": "Evc gene functions mainly in prehypertrophic and hypertrophic chondrocytes of epiphyseal growth plate. Important for future studies of underlying mechanism of chondrodysplasia in Ellis-van Creveld syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0060170 ciliary membrane;GO:0005929 cilium;GO:0036064 ciliary basal body;GO:0098797 plasma membrane protein complex", "go_biological_process": "GO:0007224 smoothened signaling pathway;GO:0045880 positive regulation of smoothened signaling pathway;GO:0051216 cartilage development;GO:0003416 endochondral bone growth", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V706-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LQ27-1", "uniprot_id": "F1LQ27_RAT", "mass": 37169.0, "length": 344, "protein_name": "Family with sequence similarity 98, member C", "gene_name": "Fam98c", "organism": "Rat", "refseq_name": "protein FAM98C", "refseq_ac": "NP_001185513", "gene_names_uniprotkb": "Fam98c", "gene_names_refseq": "Fam98c; RGD1303117", "protein_names_uniprotkb": "Family with sequence similarity 98, member C", "protein_names_refseq": "protein FAM98C", "tax_id": 10116, "disease": "", "pathway": " (rno:292764)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0072669 tRNA-splicing ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LQ27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LM48-1", "uniprot_id": "F1LM48_RAT", "mass": 14269.0, "length": 131, "protein_name": "Secretory leukocyte peptidase inhibitor, pseudogene 2", "gene_name": "Slpi-ps1; Slpi-ps2; Slpi", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Slpi-ps1; Slpi-ps2; Slpi; Slpi-ps1; Slpil3; Slpi", "gene_names_refseq": "", "protein_names_uniprotkb": "Secretory leukocyte peptidase inhibitor, pseudogene 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); endophthalmitis (Disease Ontology:DOID:4692); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:84386)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030414 peptidase inhibitor activity;GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0006955 immune response;GO:0019731 antibacterial humoral response;GO:0032496 response to lipopolysaccharide;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LM48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZEG1-1", "uniprot_id": "CRGN_RAT", "mass": 21446.0, "length": 183, "protein_name": "Gamma-crystallin N", "gene_name": "Crygn", "organism": "Rat", "refseq_name": "gamma-crystallin N", "refseq_ac": "NP_001100043", "gene_names_uniprotkb": "Crygn", "gene_names_refseq": "Crygn", "protein_names_uniprotkb": "Gamma-crystallin N; Gamma-N-crystallin", "protein_names_refseq": "gamma-N-crystallin; gamma-crystallin N", "tax_id": 10116, "disease": "", "pathway": " (rno:296730)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27517863", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens. Also plays an important role for integrity and function of auditory nuclei., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZEG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35142-1", "uniprot_id": "COPB2_RAT", "mass": 102551.0, "length": 905, "protein_name": "Coatomer subunit beta'", "gene_name": "Copb2", "organism": "Rat", "refseq_name": "coatomer subunit beta'", "refseq_ac": "NP_068533", "gene_names_uniprotkb": "Copb2; AABR07071244.1", "gene_names_refseq": "Copb2; Rack2; p102", "protein_names_uniprotkb": "Coatomer subunit beta'; Beta'-COP; Beta'-coat protein; p102", "protein_names_refseq": "COPI coat complex subunit beta 2; beta prime COP; beta'-COP; beta'-coat protein; coatomer protein complex subunit beta 2; coatomer protein complex, subunit beta 2 (beta prime); coatomer subunit beta'", "tax_id": 10116, "disease": "primary autosomal recessive microcephaly 19 (Disease Ontology:DOID:0070281); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (rno:60384); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "17360540;18556652;20801885;22673903;9360998", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Trafficking of the newly synthesized Na,K-ATPase is regulated by association with beta-COP, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030126 COPI vesicle coat;GO:0030117 membrane coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35142-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1MAR6-1", "uniprot_id": "F1MAR6_RAT", "mass": 70845.0, "length": 626, "protein_name": "Proline dehydrogenase", "gene_name": "Prodh1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Prodh1; Prodh", "gene_names_refseq": "", "protein_names_uniprotkb": "Proline dehydrogenase; 1.5.5.2", "protein_names_refseq": "", "tax_id": 10116, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); schizophrenia 4 (Disease Ontology:DOID:0070080); hyperprolinemia type 1 (Disease Ontology:DOID:0080542); schizophrenia (Disease Ontology:DOID:5419); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (R-RNO-70688)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Converts proline to delta-1-pyrroline-5-carboxylate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.5.2;1.5.5.3", "go_molecular_function": "GO:0004657 proline dehydrogenase activity;GO:0071949 FAD binding;GO:0016597 amino acid binding;GO:0016649 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005739 mitochondrion", "go_biological_process": "GO:0006562 L-proline catabolic process;GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:0010133 L-proline catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MAR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LZT2-1", "uniprot_id": "F1LZT2_RAT", "mass": 166943.0, "length": 1516, "protein_name": "KIAA0586 homolog", "gene_name": "Kiaa0586", "organism": "Rat", "refseq_name": "protein TALPID3", "refseq_ac": "NP_001414090", "gene_names_uniprotkb": "Kiaa0586; LOC690035", "gene_names_refseq": "Kiaa0586", "protein_names_uniprotkb": "KIAA0586 homolog", "protein_names_refseq": "protein TALPID3", "tax_id": 10116, "disease": "short-rib thoracic dysplasia 14 with polydactyly (Disease Ontology:DOID:0110096); Joubert syndrome 23 (Disease Ontology:DOID:0110992)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005814 centriole;GO:0036064 ciliary basal body;GO:0005813 centrosome", "go_biological_process": "GO:0007224 smoothened signaling pathway;GO:0060271 cilium assembly;GO:0070201 regulation of establishment of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LZT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LT23-1", "uniprot_id": "F1LT23_RAT", "mass": 14671.0, "length": 126, "protein_name": "Odorant binding protein 2B like 1", "gene_name": "Obp2bl1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Obp2bl1; LOC108348196", "gene_names_refseq": "", "protein_names_uniprotkb": "Odorant binding protein 2B like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LT23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2V1-1", "uniprot_id": "Q5U2V1_RAT", "mass": 65435.0, "length": 587, "protein_name": "peptidylprolyl isomerase", "gene_name": "Fkbp10", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fkbp10", "gene_names_refseq": "", "protein_names_uniprotkb": "peptidylprolyl isomerase; 5.2.1.8", "protein_names_refseq": "", "tax_id": 10116, "disease": "osteogenesis imperfecta type 11 (Disease Ontology:DOID:0110351)", "pathway": " (rno:360627)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PPIases accelerate the folding of proteins during protein synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity;GO:0005528 FK506 binding", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005758 mitochondrial intermembrane space;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0001701 in utero embryonic development;GO:0030199 collagen fibril organization;GO:0006457 protein folding;GO:0035909 aorta morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70512-1", "uniprot_id": "CISH_RAT", "mass": 28399.0, "length": 256, "protein_name": "Cytokine-inducible SH2-containing protein", "gene_name": "Cish", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cish", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytokine-inducible SH2-containing protein; CIS-1; CIS; SOCS; Suppressor of cytokine signaling", "protein_names_refseq": "", "tax_id": 10116, "disease": "malaria (Disease Ontology:DOID:12365); tuberculosis (Disease Ontology:DOID:399)", "pathway": " (rno:83681); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10579313", "class_list": "", "function": "SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERQ1", "ec_number_list": "", "go_molecular_function": "GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0016567 protein ubiquitination;GO:0019221 cytokine-mediated signaling pathway;GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O70512-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V752-1", "uniprot_id": "G3V752_RAT", "mass": 115334.0, "length": 1024, "protein_name": "RNA cytidine acetyltransferase", "gene_name": "Nat10", "organism": "Rat", "refseq_name": "RNA cytidine acetyltransferase", "refseq_ac": "NP_001386441", "gene_names_uniprotkb": "Nat10; NAT10", "gene_names_refseq": "Nat10; RGD1306717", "protein_names_uniprotkb": "RNA cytidine acetyltransferase; 18S rRNA cytosine acetyltransferase; 2.3.1.-; N-acetyltransferase 10", "protein_names_refseq": "N-acetyltransferase 10 (GCN5-related); RNA cytidine acetyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:311257)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;38724075;39251905", "class_list": "", "function": "NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; NAT10-mediated ac[4]C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.-", "go_molecular_function": "GO:0051392 tRNA cytidine N4-acetyltransferase activity;GO:1990883 18S rRNA cytidine N-acetyltransferase activity;GO:0005524 ATP binding;GO:0008080 N-acetyltransferase activity;GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030496 midbody;GO:0005697 telomerase holoenzyme complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0051391 tRNA acetylation;GO:1904812 rRNA acetylation involved in maturation of SSU-rRNA;GO:0010824 regulation of centrosome duplication;GO:0006417 regulation of translation;GO:0032211 negative regulation of telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3V752-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R715-1", "uniprot_id": "M0R715_RAT", "mass": 149696.0, "length": 1356, "protein_name": "lysophospholipase", "gene_name": "Pnpla6", "organism": "Rat", "refseq_name": "patatin-like phospholipase domain-containing protein 6 isoform X6", "refseq_ac": "XP_008767229", "gene_names_uniprotkb": "Pnpla6", "gene_names_refseq": "Pnpla6; RGD1564611", "protein_names_uniprotkb": "lysophospholipase; 3.1.1.5", "protein_names_refseq": "patatin-like phospholipase domain-containing protein 6 isoform X6", "tax_id": 10116, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); hereditary spastic paraplegia 39 (Disease Ontology:DOID:0110790); Boucher-Neuhauser syndrome (Disease Ontology:DOID:0111265); Oliver-McFarlane syndrome (Disease Ontology:DOID:0111271); neurodegenerative disease (Disease Ontology:DOID:1289); blindness (Disease Ontology:DOID:1432); Laurence-Moon syndrome (Disease Ontology:DOID:1930); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (R-RNO-6814848)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.4;3.1.1.-;3.1.1.5;3.1.1.3;3.5.1.1;3.1.1.47;3.1.1.32;3.1.1.13;3.1.1.6;3.1.2.22;3.1.2.-;3.1.2.2;2.3.1.-", "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0102545 phospholipase B activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0046470 phosphatidylcholine metabolic process;GO:0001525 angiogenesis;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "M0R715-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A2Q0-1", "uniprot_id": "FND10_RAT", "mass": 24494.0, "length": 225, "protein_name": "Fibronectin type III domain-containing protein 10", "gene_name": "Fndc10; Rps15al2", "organism": "Rat", "refseq_name": "fibronectin type III domain-containing protein 10 precursor", "refseq_ac": "NP_001406608", "gene_names_uniprotkb": "Fndc10; Rps15al2; AABR07072261.1", "gene_names_refseq": "Fndc10", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 10", "protein_names_refseq": "Fibronectin type-III domain-containing transmembrane protein C1orf233 homolog; fibronectin type III domain-containing protein 10 precursor; fibronectin type III domain-containing protein 10", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 20 (Disease Ontology:DOID:0111891)", "pathway": " (rno:100362139); (rno:680656)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0016020 membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2Q0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4JEI5-1", "uniprot_id": "Q4JEI5_RAT", "mass": 11947.0, "length": 103, "protein_name": "Defensin alpha 9", "gene_name": "Defa6; Defa9", "organism": "Rat", "refseq_name": "uncharacterized protein LOC498658 precursor", "refseq_ac": "NP_001020934", "gene_names_uniprotkb": "Defa6; Defa9; Defa6; Defa9", "gene_names_refseq": "Defa9", "protein_names_uniprotkb": "Defensin alpha 9", "protein_names_refseq": "uncharacterized protein LOC498658 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:498658); (rno:613223); (R-RNO-1461973); (R-RNO-1462054); (R-RNO-6798695)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4JEI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LZT8-1", "uniprot_id": "F1LZT8_RAT", "mass": 242306.0, "length": 2215, "protein_name": "Mediator of RNA polymerase II transcription subunit 13", "gene_name": "Med13l", "organism": "Rat", "refseq_name": "mediator of RNA polymerase II transcription subunit 13-like isoform X1", "refseq_ac": "XP_038946100", "gene_names_uniprotkb": "Med13l", "gene_names_refseq": "Med13l; Thrap2", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 13", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 13-like isoform X1", "tax_id": 10116, "disease": "dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LZT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1MAB7-1", "uniprot_id": "DGKI_RAT", "mass": 115894.0, "length": 1050, "protein_name": "Diacylglycerol kinase iota", "gene_name": "Creb3l2; Dgki", "organism": "Rat", "refseq_name": "diacylglycerol kinase iota", "refseq_ac": "NP_942077", "gene_names_uniprotkb": "Creb3l2; Dgki; Creb3l2", "gene_names_refseq": "Dgki; rDGKi-3", "protein_names_uniprotkb": "Diacylglycerol kinase iota; 2.7.1.107; DAG kinase iota", "protein_names_refseq": "DAG kinase iota; DGK-iota; diacylglycerol kinase iota-3; diacylglycerol kinase iota; diglyceride kinase iota", "tax_id": 10116, "disease": "", "pathway": " (rno:688705); (R-RNO-114508)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11244494;15024004;21119615;22673903", "class_list": "", "function": "Diacylglycerol kinase iota is exclusively found in the brain and is expressed in a distinct regional pattern. Differential expression of splice variants in the cortex of alcohol accepting (AA) and alcohol non-accepting (ANA) rat lines., [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15024004). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:15024004). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Has a decreased affinity for ATP and a reduced diacylglycerol kinase activity. Has no preference for any of the diacylglycerols in terms of the acyl chain composition., [UniProtKB, PubMed]; Has no diacylglycerol kinase activity., [UniProtKB, PubMed]; Novel splice variants, which contain either insertion 1 (71 bp) or insertion 2 (19 bp) or both in the carboxyl-terminal portion, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810C3;Q810C4;Q810C5", "ec_number_list": "2.7.1.107;2.7.1.94;2.7.1.138;2.7.1.93", "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0005095 GTPase inhibitor activity;GO:0031267 small GTPase binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0046959 habituation;GO:1900452 regulation of long-term synaptic depression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1MAB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1MAH5-1", "uniprot_id": "F1MAH5_RAT", "mass": 97572.0, "length": 873, "protein_name": "Protein phosphatase 6, regulatory subunit 3", "gene_name": "Ppp6r3", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 6 regulatory subunit 3", "refseq_ac": "NP_001382028", "gene_names_uniprotkb": "Ppp6r3; Ppp6r3-ps1; Saps3-ps1", "gene_names_refseq": "Ppp6r3-ps1; Ppp6r3; RGD1307145; Saps3-ps1; Saps3", "protein_names_uniprotkb": "Protein phosphatase 6, regulatory subunit 3", "protein_names_refseq": "SAPS domain family, member 3, pseudogene 1; serine/threonine-protein phosphatase 6 regulatory subunit 3", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-171319); (R-RNO-204005)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MAH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A7T3-1", "uniprot_id": "BRDT_RAT", "mass": 106719.0, "length": 952, "protein_name": "Bromodomain testis-specific protein", "gene_name": "Brdt", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Brdt", "gene_names_refseq": "", "protein_names_uniprotkb": "Bromodomain testis-specific protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "spermatogenic failure 21 (Disease Ontology:DOID:0070163); azoospermia (Disease Ontology:DOID:14227); oligospermia (Disease Ontology:DOID:14228)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22215678", "class_list": "", "function": "Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding;GO:0140566 histone reader activity;GO:0140008 histone H4 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A7T3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LX07-1", "uniprot_id": "S2512_RAT", "mass": 74361.0, "length": 676, "protein_name": "Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial", "gene_name": "Slc25a12", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Slc25a12", "gene_names_refseq": "", "protein_names_uniprotkb": "Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial; Solute carrier family 25 member 12", "protein_names_refseq": "", "tax_id": 10116, "disease": "Asperger syndrome (Disease Ontology:DOID:0050432); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); autism spectrum disorder (Disease Ontology:DOID:0060041); neonatal-onset type II citrullinemia (Disease Ontology:DOID:0070341); developmental and epileptic encephalopathy 39 (Disease Ontology:DOID:0080349); autistic disorder (Disease Ontology:DOID:12849); intrahepatic cholestasis (Disease Ontology:DOID:1852); common bile duct disease (Disease Ontology:DOID:4137); citrullinemia (Disease Ontology:DOID:9273)", "pathway": " (R-RNO-8963693); (R-RNO-9856872)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18683930;34502162;38843836;4436323;486467", "class_list": "", "function": "Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:4436323). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:486467). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:486467). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015172 acidic amino acid transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:2001171 positive regulation of ATP biosynthetic process;GO:0051592 response to calcium ion;GO:0010907 positive regulation of glucose metabolic process;GO:0031643 positive regulation of myelination;GO:0006537 glutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "F1LX07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LXH1-1", "uniprot_id": "F1LXH1_RAT", "mass": 134332.0, "length": 1180, "protein_name": "1-aminocyclopropane-1-carboxylate synthase-like", "gene_name": "Accsl; Accs", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Accsl; Accs; Accsl; Accs", "gene_names_refseq": "", "protein_names_uniprotkb": "1-aminocyclopropane-1-carboxylate synthase-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:311218); (rno:690470)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F7ETF2", "ec_number_list": "", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008483 transaminase activity;GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LXH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PT85-1", "uniprot_id": "E9PT85_RAT", "mass": 69486.0, "length": 608, "protein_name": "DNA repair protein Ku70", "gene_name": "Xrcc6", "organism": "Rat", "refseq_name": "X-ray repair cross-complementing protein 6", "refseq_ac": "NP_620780", "gene_names_uniprotkb": "Xrcc6", "gene_names_refseq": "G22p1; Ku70; Kup70; Xrcc6", "protein_names_uniprotkb": "DNA repair protein Ku70; 4.2.99.18; 5'-deoxyribose-5-phosphate lyase Ku70; 5.6.2.4; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; DNA repair protein XRCC6; X-ray repair cross-complementing protein 6", "protein_names_refseq": "Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa); X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6", "tax_id": 10116, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (rno:25019); (R-RNO-5693571); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "27621182", "class_list": "", "function": "Ku70 was increased in the tubuli and glomeruli of the untreated diabetic group, but decreased in all treated diabetic groups, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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in immune response;GO:0050853 B cell receptor signaling pathway;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol;GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LNH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LQW0-1", "uniprot_id": "F1LQW0_RAT", "mass": 69211.0, "length": 617, "protein_name": "Transporter", "gene_name": "Slc6a2", "organism": "Rat", "refseq_name": "sodium-dependent noradrenaline transporter", "refseq_ac": "NP_112633", "gene_names_uniprotkb": "Slc6a2", "gene_names_refseq": "Net; Slc6a2", "protein_names_uniprotkb": "Transporter", "protein_names_refseq": "NaCl-dependent norepinephrine transporter; neurotransmitter transporter, noradrenal; sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter), member 2; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; transmembrane region 4..26 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"reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005328 neurotransmitter:sodium symporter activity;GO:0046872 metal ion binding;GO:0008504 monoamine transmembrane transporter 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"Olfactory receptor family 10 subfamily D member 1B", "protein_names_refseq": "odorant receptor; olfactory receptor 1315; olfactory receptor 149; olfactory receptor Olr1315; olfactory receptor gene Olr1315", "tax_id": 10116, "disease": "", "pathway": " (rno:300616)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LPC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LRY0-1", "uniprot_id": "F1LRY0_RAT", "mass": 26077.0, "length": 232, "protein_name": "Max dimerization protein 1", "gene_name": "Mxd1", "organism": "Rat", "refseq_name": "max dimerization protein 1", "refseq_ac": "NP_001094219", "gene_names_uniprotkb": "Mxd1", "gene_names_refseq": "Mad-1; 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Sepn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Selenoprotein N", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital myopathy (Disease Ontology:DOID:0081337); rigid spine muscular dystrophy 1 (Disease Ontology:DOID:0110633)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0015882 L-ascorbic acid transmembrane transport;GO:0014816 skeletal muscle satellite cell differentiation;GO:0014858 positive regulation of skeletal muscle cell proliferation;GO:0022614 membrane to membrane docking", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LTZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LU18-1", "uniprot_id": "F1LU18_RAT", "mass": 188798.0, "length": 1721, "protein_name": "Structure-specific endonuclease subunit SLX4", "gene_name": "Slx4", "organism": "Rat", "refseq_name": "structure-specific endonuclease subunit SLX4", "refseq_ac": "NP_001385580", "gene_names_uniprotkb": "Slx4", "gene_names_refseq": "Btbd12; 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RGD1561652", "protein_names_uniprotkb": "Oxysterol-binding protein", "protein_names_refseq": "oxysterol-binding protein-related protein 10", "tax_id": 10116, "disease": "", "pathway": " (rno:316039); (R-RNO-1482801)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0001786 phosphatidylserine binding;GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006649 phospholipid transfer to membrane;GO:0055091 phospholipid homeostasis;GO:0097212 lysosomal membrane organization;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LWM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LXA4-1", "uniprot_id": "F1LXA4_RAT", "mass": 56966.0, "length": 499, "protein_name": "Cytochrome P450", "gene_name": "Cyp2ac1", "organism": "Rat", "refseq_name": "cytochrome P450, family 2, subfamily ac, polypeptide 1", "refseq_ac": "NP_001420341", "gene_names_uniprotkb": "Cyp2ac1", "gene_names_refseq": "AABR07066946.2; Cyp2ac1; RGD1564244", "protein_names_uniprotkb": "Cytochrome P450; 1.14.14.-", "protein_names_refseq": "cytochrome P450 2C14-like; cytochrome P450 2K1-like; cytochrome P450 2K4-like; cytochrome P450 2K6-like; cytochrome P450, family 2, subfamily ac, polypeptide 1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.-;1.14.13.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006082 organic acid metabolic process;GO:0046222 aflatoxin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LXA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LXS4-1", "uniprot_id": "F1LXS4_RAT", "mass": 58320.0, "length": 519, "protein_name": "TLE family member 6, subcortical maternal complex member", "gene_name": "Tle6", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tle6; 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Usp50", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12", "protein_names_refseq": "inactive ubiquitin carboxyl-terminal hydrolase 50; ubiquitin specific peptidase 50 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:311399)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates the inflammasome signaling pathway by deubiquitinating 'Lys-63'-linked polyubiquitination of the PYCARD/ASC adapter protein. Regulates the ubiquitination and stability of the ACE2 protein. Acts as a negative regulator of the G2/M checkpoint pathway, by preventing serine/threonine kinase WEE1 degradation, thereby repressing entry into mitosis following activation of the G2/M DNA damage checkpoint., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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"F1LZ11-1", "uniprot_id": "F1LZ11_RAT", "mass": 11320.0, "length": 102, "protein_name": "Ig-like domain-containing protein", "gene_name": "AABR07065814.2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AABR07065814.2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, 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"uniprot_canonical_ac": "F1M051-1", "uniprot_id": "F1M051_RAT", "mass": 101573.0, "length": 926, "protein_name": "MLX interacting protein", "gene_name": "Mlxip", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mlxip", "gene_names_refseq": "", "protein_names_uniprotkb": "MLX interacting protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:304479)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Cdh18", "protein_names_uniprotkb": "Cadherin 18", "protein_names_refseq": "cadherin 14; cadherin 18, type 2; cadherin-18 precursor", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:310174); (R-RNO-418990)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M702-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1M7P1-1", "uniprot_id": "F1M7P1_RAT", "mass": 51368.0, "length": 445, "protein_name": "DDB1- and CUL4-associated factor 13", "gene_name": "Dcaf13", "organism": "Rat", "refseq_name": "DDB1- and CUL4-associated factor 13", "refseq_ac": "NP_001167029", "gene_names_uniprotkb": "Dcaf13", "gene_names_refseq": "Dcaf13; Gm83; Wdsof1", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 13; WD repeat and SOF domain-containing protein 1", "protein_names_refseq": "DDB1- and CUL4-associated factor 13; WD repeats and SOF domain containing 1; WD repeats and SOF1 domain containing", "tax_id": 10116, "disease": "", "pathway": " (rno:362902); (R-RNO-6791226); (R-RNO-8951664)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030331 nuclear estrogen receptor binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006364 rRNA processing;GO:0046697 decidualization;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0007056 spindle assembly involved in female meiosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M7P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1M8C8-1", "uniprot_id": "F1M8C8_RAT", "mass": 24112.0, "length": 209, "protein_name": "Transmembrane protein 186", "gene_name": "Tmem186l1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tmem186l1; AABR07057217.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein 186", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M8C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1M8K0-1", "uniprot_id": "F1M8K0_RAT", "mass": 96706.0, "length": 893, "protein_name": "Dystroglycan 1", "gene_name": "Dag1", "organism": "Rat", "refseq_name": "dystroglycan 1 precursor", "refseq_ac": "NP_446149", "gene_names_uniprotkb": "Dag1", "gene_names_refseq": "Dag1", "protein_names_uniprotkb": "Dystroglycan 1; Dystroglycan; Dystrophin-associated glycoprotein 1", "protein_names_refseq": "alpha-dystroglycan; beta-dystroglycan; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystroglycan 1 precursor", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Fukuyama congenital muscular dystrophy (Disease Ontology:DOID:0050559); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); autosomal recessive limb-girdle muscular dystrophy type 2D (Disease Ontology:DOID:0110278); autosomal recessive limb-girdle muscular dystrophy type 2P (Disease Ontology:DOID:0110293); congenital muscular dystrophy-dystroglycanopathy type A9 (Disease Ontology:DOID:0111232); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); inclusion body myositis (Disease Ontology:DOID:3429); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767); type 2 diabetes mellitus (Disease Ontology:DOID:9352); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:114489); (R-RNO-8932504); (R-RNO-8932505); (R-RNO-8932506); (R-RNO-9913351); (R-RNO-9939291)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "16641100;22673903;34160889;35169214;38843836", "class_list": "", "function": "MiR-132 down-regulates high glucose-induced beta-dystroglycan degradation through Matrix Metalloproteinases-9 up-regulation in primary neurons., [RefSeq, PubMed]; The cell adhesion protein dystroglycan affects the structural remodeling of dendritic spines. Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0085029 extracellular matrix assembly;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0006509 membrane protein ectodomain proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "F1M8K0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1M8T9-1", "uniprot_id": "F1M8T9_RAT", "mass": 36217.0, "length": 324, "protein_name": "Olfactory receptor", "gene_name": "Olr1877", "organism": "Rat", "refseq_name": "olfactory receptor 1877", "refseq_ac": "NP_001395792", "gene_names_uniprotkb": "Olr1877; Olr1102", "gene_names_refseq": "Olr1877; RGD1560560", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 10AD1-like; olfactory receptor 1877", "tax_id": 10116, "disease": "", "pathway": " (rno:500927)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Possible taste receptor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M8T9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1M8Z6-1", "uniprot_id": "F1M8Z6_RAT", "mass": 74007.0, "length": 695, "protein_name": "TNF receptor superfamily member 11A", "gene_name": "Tnfrsf11a", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tnfrsf11a", "gene_names_refseq": "", "protein_names_uniprotkb": "TNF receptor superfamily member 11A", "protein_names_refseq": "", "tax_id": 10116, "disease": "bone development disease (Disease Ontology:DOID:0080006); Paget's disease of bone 2 (Disease Ontology:DOID:0081365); autosomal recessive osteopetrosis 7 (Disease Ontology:DOID:0110946); familial expansile osteolysis (Disease Ontology:DOID:0111542); stomach cancer (Disease Ontology:DOID:10534); osteoporosis (Disease Ontology:DOID:11476); Paget's disease of bone (Disease Ontology:DOID:5408); myocarditis (Disease Ontology:DOID:820)", "pathway": " (rno:498206); (R-RNO-5668541); (R-RNO-5676594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005031 tumor necrosis factor receptor activity;GO:0019955 cytokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0060086 circadian temperature homeostasis;GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion;GO:0032496 response to lipopolysaccharide;GO:0034612 response to tumor necrosis factor", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M8Z6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1M946-1", "uniprot_id": "F1M946_RAT", "mass": 34944.0, "length": 312, "protein_name": "Olfactory receptor family 7 subfamily E member 173D", "gene_name": "Or7e178", "organism": "Rat", "refseq_name": "olfactory receptor Olr1166", "refseq_ac": "NP_001000867", "gene_names_uniprotkb": "Or7e178; Or7e173d; Or7e24", "gene_names_refseq": "Olr1166; Or7e173d; Or7e173", "protein_names_uniprotkb": "Olfactory receptor family 7 subfamily E member 173D", "protein_names_refseq": "olfactory receptor 1166; olfactory receptor Olr1166; olfactory receptor family 7 subfamily E member 173; olfactory receptor gene Olr1166", "tax_id": 10116, "disease": "", "pathway": " (rno:405164); (rno:690849)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M946-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1M977-1", "uniprot_id": "F1M977_RAT", "mass": 59463.0, "length": 511, "protein_name": "Zinc finger protein 952", "gene_name": "Zfp952", "organism": "Rat", "refseq_name": "zinc finger protein 952", "refseq_ac": "NP_001419089", "gene_names_uniprotkb": "Zfp952", "gene_names_refseq": "AZF17; Zfp952", "protein_names_uniprotkb": "Zinc finger protein 952", "protein_names_refseq": "rCG29177-like; zinc finger protein 17; zinc finger protein 501; zinc finger protein 952", "tax_id": 10116, "disease": "", "pathway": " (rno:100360287); (R-RNO-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M977-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1M9J5-1", "uniprot_id": "F1M9J5_RAT", "mass": 11845.0, "length": 104, "protein_name": "Uncharacterized protein", "gene_name": "Esp1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Esp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005186 pheromone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M9J5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1MA10-1", "uniprot_id": "F1MA10_RAT", "mass": 34216.0, "length": 306, "protein_name": "NAD(P)(+)--arginine ADP-ribosyltransferase", "gene_name": "Art4", "organism": "Rat", "refseq_name": "ecto-ADP-ribosyltransferase 4 precursor", "refseq_ac": "NP_001166980", "gene_names_uniprotkb": "Art4", "gene_names_refseq": "ATR4; 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immunoglobulin lambda-like polypeptide 5", "tax_id": 10116, "disease": "agammaglobulinemia 2 (Disease Ontology:DOID:0081135)", "pathway": " (rno:100360919); (R-RNO-173623); (R-RNO-198933); (R-RNO-202733); (R-RNO-2029481); (R-RNO-2029482); (R-RNO-2029485); (R-RNO-2168880); (R-RNO-2454202); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-2871837); (R-RNO-5690714); (R-RNO-977606); (R-RNO-983695)", "pathway_count": 16, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MAM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F2Z3R0-1", "uniprot_id": "F2Z3R0_RAT", "mass": 38817.0, "length": 350, "protein_name": "Kelch domain containing 8A", "gene_name": "Klhdc8a", "organism": "Rat", "refseq_name": "kelch domain-containing protein 8A isoform 1", "refseq_ac": "NP_001094153", "gene_names_uniprotkb": "Klhdc8a", "gene_names_refseq": "Klhdc8a; 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RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Could also play a role in RNA transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006469 negative regulation of protein kinase activity;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7EMB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F7ENE7-1", "uniprot_id": "F7ENE7_RAT", "mass": 45737.0, "length": 409, "protein_name": "RCAN family member 3", "gene_name": "Rcan3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rcan3", "gene_names_refseq": "", "protein_names_uniprotkb": "RCAN family member 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0019902 phosphatase binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity;GO:0031013 troponin I binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7ENE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F7ETL6-1", "uniprot_id": "F7ETL6_RAT", "mass": 92409.0, "length": 846, "protein_name": "Zinc finger protein 341", "gene_name": "Zfp341", "organism": "Rat", "refseq_name": "zinc finger protein 341 isoform 1", "refseq_ac": "NP_001417321", "gene_names_uniprotkb": "Zfp341", "gene_names_refseq": "AABR07054367.1; LRRGT00145; Zfp341; Zfp966; Znf341", "protein_names_uniprotkb": "Zinc finger protein 341", "protein_names_refseq": "zinc finger protein 341 isoform 1; zinc finger protein 966", "tax_id": 10116, "disease": "autosomal recessive hyper-IgE syndrome 3 with recurrent infections (Disease Ontology:DOID:0080595)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0001216 DNA-binding transcription activator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7ETL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F7F588-1", "uniprot_id": "F7F588_RAT", "mass": 27578.0, "length": 245, "protein_name": "Nicotinamide-nucleotide adenylyltransferase", "gene_name": "Nmnat3", "organism": "Rat", "refseq_name": "nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3", "refseq_ac": "NP_001382630", "gene_names_uniprotkb": "Nmnat3", "gene_names_refseq": "Nmnat3", "protein_names_uniprotkb": "Nicotinamide-nucleotide adenylyltransferase; 2.7.7.18; 2.7.7.1", "protein_names_refseq": "nicotinamide mononucleotide adenylyltransferase 3; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); glaucoma (Disease Ontology:DOID:1686)", "pathway": " (rno:363118); (R-RNO-196807)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16641100;24136224;27423420", "class_list": "", "function": "Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity., [UniProtKB, UniProtKB]; NMNAT3 regulates the activity of SIRT3 via synthesis of mitochondria NAD., [RefSeq, PubMed]; These results suggest that the axonal-protective effect of Nmnat3 may be involved in autophagy machinery. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.1;2.7.7.18", "go_molecular_function": "GO:0005524 ATP binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0034612 response to tumor necrosis factor;GO:0009611 response to wounding;GO:0009435 NAD+ biosynthetic process;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F7F588-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F7F947-1", "uniprot_id": "F7F947_RAT", "mass": 23469.0, "length": 216, "protein_name": "Beta-defensin-like domain-containing protein", "gene_name": "Spag11bl1; Spag11b", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Spag11bl1; Spag11b; LOC120093117; Spag11bl1; Spag11bl", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-defensin-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has antimicrobial activity against E.coli. Plays a role in the defense response in the male reproductive tract, contributing to sperm maturation, storage and protection., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7F947-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F7FFS7-1", "uniprot_id": "F7FFS7_RAT", "mass": 30929.0, "length": 274, "protein_name": "TNF receptor superfamily member 18", "gene_name": "Tnfrsf18", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tnfrsf18", "gene_names_refseq": "", "protein_names_uniprotkb": "TNF receptor superfamily member 18", "protein_names_refseq": "", "tax_id": 10116, "disease": "anogenital venereal wart (Disease Ontology:DOID:11168); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321)", "pathway": " (R-RNO-5669034)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005031 tumor necrosis factor receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045785 positive regulation of cell adhesion;GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein;GO:0002687 positive regulation of leukocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7FFS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F7FJQ3-1", "uniprot_id": "F7FJQ3_RAT", "mass": 19905.0, "length": 181, "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "Npc2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Npc2", "gene_names_refseq": "", "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 2; Epididymal secretory protein E1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Niemann-Pick disease type C2 (Disease Ontology:DOID:0070114); Niemann-Pick disease (Disease Ontology:DOID:14504)", "pathway": " (rno:286898); (R-RNO-6798695); (R-RNO-8964038)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0005770 late endosome;GO:0043202 lysosomal lumen;GO:0005576 extracellular region", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0009615 response to virus;GO:0032367 intracellular cholesterol transport;GO:0033344 cholesterol efflux;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7FJQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V606-1", "uniprot_id": "G3V606_RAT", "mass": 30996.0, "length": 282, "protein_name": "UBX domain-containing protein 10", "gene_name": "Ubxn10", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ubxn10", "gene_names_refseq": "", "protein_names_uniprotkb": "UBX domain-containing protein 10; UBX domain-containing protein 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "VCP/p97-binding protein required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia. UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005929 cilium;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0060271 cilium assembly;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V606-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V634-1", "uniprot_id": "G3V634_RAT", "mass": 27758.0, "length": 261, "protein_name": "GS homeobox 1", "gene_name": "Gsx1", "organism": "Rat", "refseq_name": "GS homeobox 1", "refseq_ac": "NP_001178592", "gene_names_uniprotkb": "Gsx1", "gene_names_refseq": "Gsh1; Gsx1", "protein_names_uniprotkb": "GS homeobox 1", "protein_names_refseq": "GS homeobox 1; genomic screened homeo box 1", "tax_id": 10116, "disease": "", "pathway": " (rno:288457)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V634-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V658-1", "uniprot_id": "G3V658_RAT", "mass": 67245.0, "length": 619, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "Dtx2", "organism": "Rat", "refseq_name": "probable E3 ubiquitin-protein ligase DTX2", "refseq_ac": "NP_001100627", "gene_names_uniprotkb": "Dtx2", "gene_names_refseq": "Dtx2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27", "protein_names_refseq": "deltex 2 homolog; deltex 2, E3 ubiquitin ligase; deltex homolog 2; probable E3 ubiquitin-protein ligase DTX2; protein deltex-2", "tax_id": 10116, "disease": "", "pathway": " (rno:304591); (R-RNO-2122948)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V658-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V670-1", "uniprot_id": "G3V670_RAT", "mass": 37085.0, "length": 334, "protein_name": "Methionine aminopeptidase", "gene_name": "Metap1d", "organism": "Rat", "refseq_name": "methionine aminopeptidase 1D, mitochondrial", "refseq_ac": "NP_001101282", "gene_names_uniprotkb": "Metap1d", "gene_names_refseq": "Map1d; Metap1d; Metapl1", "protein_names_uniprotkb": "Methionine aminopeptidase; 3.4.11.18", "protein_names_refseq": "methionine aminopeptidase 1D, mitochondrial; methionine aminopeptidase-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:311748)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006508 proteolysis;GO:0043687 post-translational protein modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V670-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V6C0-1", "uniprot_id": "G3V6C0_RAT", "mass": 127692.0, "length": 1156, "protein_name": "MHC class II transactivator", "gene_name": "Ciita", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ciita", "gene_names_refseq": "", "protein_names_uniprotkb": "MHC class II transactivator; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "osteoporosis (Disease Ontology:DOID:11476); Addison's disease (Disease Ontology:DOID:13774); multiple sclerosis (Disease Ontology:DOID:2377); MHC class II deficiency (Disease Ontology:DOID:5812); myocardial infarction (Disease Ontology:DOID:5844); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); periapical periodontitis (Disease Ontology:DOID:823); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:85483)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0009986 cell surface;GO:0016605 PML body", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0060333 type II interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6C0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V6M6-1", "uniprot_id": "G3V6M6_RAT", "mass": 36809.0, "length": 338, "protein_name": "T-cell leukemia, homeobox 3", "gene_name": "Tlx3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tlx3", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell leukemia, homeobox 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731)", "pathway": " (rno:497881)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001708 cell fate specification;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045665 negative regulation of neuron differentiation;GO:0001764 neuron migration;GO:0002087 regulation of respiratory gaseous exchange by nervous system process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6M6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V6P4-1", "uniprot_id": "G3V6P4_RAT", "mass": 36500.0, "length": 325, "protein_name": "Phosphoethanolamine/phosphocholine phosphatase", "gene_name": "Phospho1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Phospho1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphoethanolamine/phosphocholine phosphatase; 3.1.3.75", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287644); (R-RNO-1483191); (R-RNO-1483213)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.75;3.1.3.1;3.9.1.1", "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0052731 phosphocholine phosphatase activity;GO:0052732 phosphoethanolamine phosphatase activity;GO:0046872 metal ion binding;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0065010 extracellular membrane-bounded organelle;GO:0031012 extracellular matrix;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0035630 bone mineralization involved in bone maturation;GO:0030282 bone mineralization;GO:0001958 endochondral ossification;GO:0030500 regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6P4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V6R7-1", "uniprot_id": "G3V6R7_RAT", "mass": 47987.0, "length": 456, "protein_name": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial", "gene_name": "Oxsm", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Oxsm", "gene_names_refseq": "", "protein_names_uniprotkb": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; 2.3.1.41", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:289934); (R-RNO-9837999)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.5;1.3.8.5;6.2.1.4;4.98.1.1;5.6.2.3;2.8.3.5;2.3.1.-;2.3.1.41;3.4.21.92;3.5.3.1;3.1.2.2;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.2.-;1.1.1.37;6.4.1.3;7.1.2.2;1.4.1.3;1.2.1.3;1.1.1.100;1.3.1.39;2.3.1.38;2.3.1.39;2.3.1.85;3.1.2.14;4.2.1.59;2.3.1.37;4.2.1.2;2.3.1.9;2.3.3.10;5.3.3.8;1.1.1.30;3.6.4.10;1.2.4.1;1.1.1.42;5.6.1.7;1.3.8.1;2.7.1.23;1.2.4.2;5.3.3.21;2.7.11.2;2.7.11.-;7.1.1.2;1.2.1.36;1.7.1.-;1.2.1.28;1.8.1.4;2.3.3.1;3.4.21.53;1.1.1.41;4.2.1.3", "go_molecular_function": "GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0051792 medium-chain fatty acid biosynthetic process;GO:0051790 short-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6R7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V6X8-1", "uniprot_id": "G3V6X8_RAT", "mass": 118219.0, "length": 1109, "protein_name": "GLI family zinc finger 1", "gene_name": "Gli1", "organism": "Rat", "refseq_name": "zinc finger protein GLI1", "refseq_ac": "NP_001178839", "gene_names_uniprotkb": "Gli1", "gene_names_refseq": "Gli1; Gli", "protein_names_uniprotkb": "GLI family zinc finger 1", "protein_names_refseq": "GLI-Kruppel family member GLI1; zinc finger protein GLI1", "tax_id": 10116, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); pre-malignant neoplasm (Disease Ontology:DOID:0060071); preaxial polydactyly I (Disease Ontology:DOID:0060987); spina bifida (Disease Ontology:DOID:0080016); multiple sclerosis (Disease Ontology:DOID:2377); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); gallbladder cancer (Disease Ontology:DOID:3121); gastric papillary adenocarcinoma (Disease Ontology:DOID:5593); gastric tubular adenocarcinoma (Disease Ontology:DOID:6595); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (rno:140589); (R-RNO-5610780); (R-RNO-5610787); (R-RNO-5632684)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "29393594;31868509;32298032;35810662;37516284", "class_list": "", "function": "Enhancement of biochemical and genomic pathways through lycopene-loaded nano-liposomes: Alleviating insulin resistance, hepatic steatosis, and autophagy in obese rats with non-alcoholic fatty liver disease: Involvement of SMO, GLI-1, and PTCH-1 genes., [RefSeq, PubMed]; GLI1 enhanced apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) expression by binding with its promoter, [RefSeq, PubMed]; Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension., [RefSeq, PubMed]; Regulation of epithelial-mesenchymal transition via sonic hedgehog/glioma-associated oncogene homolog 1 signaling pathway in peritoneal mesothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007418 ventral midline development;GO:0009913 epidermal cell differentiation;GO:0021696 cerebellar cortex morphogenesis;GO:0060032 notochord regression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3V6X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V707-1", "uniprot_id": "G3V707_RAT", "mass": 43981.0, "length": 386, "protein_name": "Adiponectin receptor 2", "gene_name": "Adipor2", "organism": "Rat", "refseq_name": "adiponectin receptor protein 2", "refseq_ac": "NP_001033068", "gene_names_uniprotkb": "Adipor2", "gene_names_refseq": "Adipor2", "protein_names_uniprotkb": "Adiponectin receptor 2", "protein_names_refseq": "adiponectin receptor protein 2", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); glucose intolerance (Disease Ontology:DOID:10603); hyperinsulinism (Disease Ontology:DOID:2018); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-163680)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16415076;34973951;35271883", "class_list": "", "function": "AdipoR2 might play a role in the pathogenesis of endothelin-1-related cardiomyocyte hypertrophy after myocardial infarction, [RefSeq, PubMed]; Crosstalk relationship between adiponectin receptors, PPAR-gamma and alpha-adrenoceptors in renal vasculature of diabetic WKYs., [RefSeq, PubMed]; The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0055100 adiponectin binding;GO:0038023 signaling receptor activity;GO:0097003 adipokinetic hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007507 heart development;GO:0007584 response to nutrient;GO:0010629 negative regulation of gene expression;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3V707-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V798-1", "uniprot_id": "G3V798_RAT", "mass": 55675.0, "length": 488, "protein_name": "Serine and arginine rich splicing factor 4", "gene_name": "Srsf4", "organism": "Rat", "refseq_name": "serine/arginine-rich splicing factor 4", "refseq_ac": "NP_001102155", "gene_names_uniprotkb": "Srsf4", "gene_names_refseq": "RGD1561347; Sfrs4; Srsf4", "protein_names_uniprotkb": "Serine and arginine rich splicing factor 4", "protein_names_refseq": "serine/arginine-rich splicing factor 4; splicing factor, arginine/serine-rich 4", "tax_id": 10116, "disease": "Down syndrome (Disease Ontology:DOID:14250); colon adenocarcinoma (Disease Ontology:DOID:234); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:362612)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0032868 response to insulin;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V7A4-1", "uniprot_id": "G3V7A4_RAT", "mass": 34644.0, "length": 307, "protein_name": "Necdin", "gene_name": "Ndn", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ndn", "gene_names_refseq": "", "protein_names_uniprotkb": "Necdin", "protein_names_refseq": "", "tax_id": 10116, "disease": "Prader-Willi syndrome (Disease Ontology:DOID:11983)", "pathway": " (rno:308690)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043015 gamma-tubulin binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0042995 cell projection", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0003016 respiratory system process;GO:0007409 axonogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7A4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V865-1", "uniprot_id": "G3V865_RAT", "mass": 42884.0, "length": 399, "protein_name": "Solute carrier family 25 member 28", "gene_name": "Slc25a28", "organism": "Rat", "refseq_name": "mitoferrin-2 isoform X1", "refseq_ac": "XP_006231629", "gene_names_uniprotkb": "Slc25a28", "gene_names_refseq": "Slc25a28", "protein_names_uniprotkb": "Solute carrier family 25 member 28", "protein_names_refseq": "mitoferrin-2 isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015093 ferrous iron transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0048250 iron import into the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V865-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V8D7-1", "uniprot_id": "G3V8D7_RAT", "mass": 39426.0, "length": 361, "protein_name": "Gap junction protein", "gene_name": "Gjd4", "organism": "Rat", "refseq_name": "gap junction delta-4 protein", "refseq_ac": "NP_001093957", "gene_names_uniprotkb": "Gjd4", "gene_names_refseq": "Cx39; Gjd4", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "connexin 39; gap junction channel protein; gap junction delta-4 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:266707); (R-RNO-190861)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19129462", "class_list": "", "function": "Report regulation of connexin 39 gene expression during skeletal muscle regeneration in the adult rat., [RefSeq, PubMed]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0014717 regulation of satellite cell activation involved in skeletal muscle regeneration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V8D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V8E4-1", "uniprot_id": "G3V8E4_RAT", "mass": 38252.0, "length": 354, "protein_name": "Ubiquitin domain-containing protein UBFD1", "gene_name": "Ubfd1", "organism": "Rat", "refseq_name": "ubiquitin domain-containing protein UBFD1 isoform X1", "refseq_ac": "XP_006230251", "gene_names_uniprotkb": "Ubfd1", "gene_names_refseq": "RGD1306614; Ubfd1; Ubph", "protein_names_uniprotkb": "Ubiquitin domain-containing protein UBFD1", "protein_names_refseq": "ubiquitin domain-containing protein UBFD1 isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V8J6-1", "uniprot_id": "G3V8J6_RAT", "mass": 37405.0, "length": 348, "protein_name": "Homeobox protein GBX-2", "gene_name": "Gbx2", "organism": "Rat", "refseq_name": "homeobox protein GBX-2", "refseq_ac": "NP_446160", "gene_names_uniprotkb": "Gbx2", "gene_names_refseq": "Gbx2", "protein_names_uniprotkb": "Homeobox protein GBX-2; Gastrulation and brain-specific homeobox protein 2", "protein_names_refseq": "homeobox protein GBX-2", "tax_id": 10116, "disease": "", "pathway": " (rno:114500)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a transcription factor for cell pluripotency and differentiation in the embryo., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021555 midbrain-hindbrain boundary morphogenesis;GO:0021568 rhombomere 2 development;GO:0048483 autonomic nervous system development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V8Q4-1", "uniprot_id": "G3V8Q4_RAT", "mass": 134733.0, "length": 1234, "protein_name": "Retinol-binding protein 3", "gene_name": "Rbp3", "organism": "Rat", "refseq_name": "retinol-binding protein 3 precursor", "refseq_ac": "NP_001178761", "gene_names_uniprotkb": "Rbp3", "gene_names_refseq": "Irbp; Rbp3", "protein_names_uniprotkb": "Retinol-binding protein 3; Interphotoreceptor retinoid-binding protein; Interstitial retinol-binding protein", "protein_names_refseq": "interphotoreceptor retinoid binding protein; interphotoreceptor retinol- binding protein; retinol binding protein 3, interstitial; retinol-binding protein 2; retinol-binding protein 3 precursor", "tax_id": 10116, "disease": "retinitis pigmentosa 66 (Disease Ontology:DOID:0110393)", "pathway": " (rno:24711); (R-RNO-2187335); (R-RNO-2453902)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0005615 extracellular space;GO:0090658 cone matrix sheath", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006508 proteolysis;GO:0042462 eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V915-1", "uniprot_id": "G3V915_RAT", "mass": 83222.0, "length": 738, "protein_name": "Ribonuclease L", "gene_name": "Rnasel", "organism": "Rat", "refseq_name": "2-5A-dependent ribonuclease", "refseq_ac": "NP_872614", "gene_names_uniprotkb": "Rnasel", "gene_names_refseq": "Rnasel", "protein_names_uniprotkb": "Ribonuclease L", "protein_names_refseq": "2-5A-dependent ribonuclease; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent)", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (R-RNO-8983711); (R-RNO-909733)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V932-1", "uniprot_id": "G3V932_RAT", "mass": 36987.0, "length": 325, "protein_name": "MAGE family member B18", "gene_name": "Mageb18", "organism": "Rat", "refseq_name": "melanoma-associated antigen B18", "refseq_ac": "NP_001037711", "gene_names_uniprotkb": "Mageb18", "gene_names_refseq": "Mageb18; 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AMBP1; Cfh; Fh", "protein_names_uniprotkb": "Complement factor H", "protein_names_refseq": "adrenomedullin binding protein-1; complement component factor H; complement factor H precursor; complement inhibitory factor H; platelet complement factor H", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); basal laminar drusen (Disease Ontology:DOID:0060746); lupus nephritis (Disease Ontology:DOID:0080162); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); COVID-19 (Disease Ontology:DOID:0080600); age related macular degeneration 4 (Disease Ontology:DOID:0110017); membranous glomerulonephritis (Disease Ontology:DOID:10976); sarcoidosis (Disease Ontology:DOID:11335); panuveitis (Disease Ontology:DOID:12030); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); posterior uveitis (Disease Ontology:DOID:12574); cardiovascular system disease (Disease Ontology:DOID:1287); obstructive jaundice (Disease Ontology:DOID:13603); anterior uveitis (Disease Ontology:DOID:1407); 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Publication Status: Online-Only, [RefSeq, PubMed]; Expression and regulation in cultured heptocytes, Kupffer cells, and hepatoma cell lines, [RefSeq, PubMed]; Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molecular cloning, sequencing and quantification with a newly established ELISA, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0001851 complement component C3b binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0035886 vascular associated smooth muscle cell differentiation;GO:0002434 immune complex clearance;GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3V9R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V9S1-1", "uniprot_id": "G3V9S1_RAT", "mass": 34406.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or2c1", "organism": "Rat", "refseq_name": "olfactory receptor Olr1356", "refseq_ac": "NP_001000493", "gene_names_uniprotkb": "Or2c1", "gene_names_refseq": "Olr1356; Or2c1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1356; olfactory receptor Olr1356; olfactory receptor gene Olr1356", "tax_id": 10116, "disease": "", "pathway": " (rno:302954)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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[provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "GO:0050907 detection of chemical stimulus involved in sensory perception;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V9S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "H7C5Y4-1", "uniprot_id": "H7C5Y4_RAT", "mass": 70702.0, "length": 633, "protein_name": "Zinc finger protein 251", "gene_name": "Zfp251", "organism": "Rat", "refseq_name": "zinc finger protein 251", "refseq_ac": "NP_001178840", "gene_names_uniprotkb": "Zfp251", "gene_names_refseq": "Zfp251; Znf251", "protein_names_uniprotkb": "Zinc finger protein 251", "protein_names_refseq": "zinc finger protein 251", "tax_id": 10116, "disease": "", "pathway": " (rno:366954)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0061484 hematopoietic stem cell homeostasis;GO:0022603 regulation of anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "H7C5Y4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R438-1", "uniprot_id": "M0R438_RAT", "mass": 34017.0, "length": 306, "protein_name": "Olfactory receptor", "gene_name": "Or2ak6c", "organism": "Rat", "refseq_name": "olfactory receptor Olr1437", "refseq_ac": "NP_001000015", "gene_names_uniprotkb": "Or2ak6c; Or2ak6", "gene_names_refseq": "Olr1437; Or2ak6c", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1437; olfactory receptor 2AK2-like; olfactory receptor Olr1437; olfactory receptor gene Olr1437", "tax_id": 10116, "disease": "", "pathway": " (rno:287325)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R438-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R4C6-1", "uniprot_id": "M0R4C6_RAT", "mass": 57020.0, "length": 509, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "4932415M13Rikl", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "4932415M13Rikl; LOC134480323; LOC301165", "gene_names_refseq": "", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R4C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R4D0-1", "uniprot_id": "M0R4D0_RAT", "mass": 21953.0, "length": 211, "protein_name": "Transmembrane protein 235", "gene_name": "Tmem235", "organism": "Rat", "refseq_name": "transmembrane protein 235 isoform 1", "refseq_ac": "NP_001417199", "gene_names_uniprotkb": "Tmem235; LOC688285", "gene_names_refseq": "Tmem235", "protein_names_uniprotkb": "Transmembrane protein 235", "protein_names_refseq": "transmembrane protein 235 isoform 1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R4D0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R4H2-1", "uniprot_id": "M0R4H2_RAT", "mass": 35476.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or8k22", "organism": "Rat", "refseq_name": "olfactory receptor Olr491", "refseq_ac": "NP_001000932", "gene_names_uniprotkb": "Or8k22", "gene_names_refseq": "Olr491; Or8k22", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 491; olfactory receptor 8K3-like; olfactory receptor Olr491; olfactory receptor gene Olr491", "tax_id": 10116, "disease": "", "pathway": " (rno:405252)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R4H2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R4K3-1", "uniprot_id": "M0R4K3_RAT", "mass": 114737.0, "length": 1087, "protein_name": "Zinc finger CCHC-type containing 14", "gene_name": "Zcchc14", "organism": "Rat", "refseq_name": "zinc finger CCHC domain-containing protein 14", "refseq_ac": "NP_001414235", "gene_names_uniprotkb": "Zcchc14", "gene_names_refseq": "RGD1309494; Zcchc14", "protein_names_uniprotkb": "Zinc finger CCHC-type containing 14", "protein_names_refseq": "zinc finger CCHC domain-containing protein 14; zinc finger, CCHC domain containing 14", "tax_id": 10116, "disease": "", "pathway": " (rno:365018)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R4K3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R4P9-1", "uniprot_id": "M0R4P9_RAT", "mass": 20655.0, "length": 183, "protein_name": "Ubiquitin-conjugating enzyme E2 H", "gene_name": "Ube2h", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 H", "refseq_ac": "NP_001165598", "gene_names_uniprotkb": "Ube2h", "gene_names_refseq": "Ube2h", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 H; (E3-independent) E2 ubiquitin-conjugating enzyme H; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme H; Ubiquitin carrier protein H; Ubiquitin-conjugating enzyme E2-20K; Ubiquitin-protein ligase H", "protein_names_refseq": "ubiquitin-conjugating enzyme E2 H", "tax_id": 10116, "disease": "viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (rno:296956)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R4P9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R515-1", "uniprot_id": "M0R515_RAT", "mass": 39352.0, "length": 352, "protein_name": "NAD(P)H pyrophosphatase NUDT13, mitochondrial", "gene_name": "Nudt13", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nudt13", "gene_names_refseq": "", "protein_names_uniprotkb": "NAD(P)H pyrophosphatase NUDT13, mitochondrial; 3.6.1.22; Nucleoside diphosphate-linked moiety X motif 13", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-499943)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "NAD(P)H pyrophosphatase that hydrolyzes NADH into NMNH and AMP, and NADPH into NMNH and 2',5'-ADP. Has a marked preference for the reduced pyridine nucleotides. Does not show activity toward NAD-capped RNAs; the NAD-cap is an atypical cap present at the 5'-end of some RNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.1.22;2.7.7.2;3.6.1.18;3.6.1.-;3.1.-.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0035529 NADH pyrophosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R515-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R583-1", "uniprot_id": "M0R583_RAT", "mass": 34461.0, "length": 307, "protein_name": "Phosphatidylinositol-specific phospholipase C, X domain containing 1", "gene_name": "Plcxd1", "organism": "Rat", "refseq_name": "PI-PLC X domain-containing protein 1", "refseq_ac": "NP_001414625", "gene_names_uniprotkb": "Plcxd1", "gene_names_refseq": "Plcxd1; RGD1560935", "protein_names_uniprotkb": "Phosphatidylinositol-specific phospholipase C, X domain containing 1", "protein_names_refseq": "PI-PLC X domain-containing protein 1-like; PI-PLC X domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R583-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R5T3-1", "uniprot_id": "M0R5T3_RAT", "mass": 59973.0, "length": 518, "protein_name": "Zinc finger protein 449", "gene_name": "Zfp449", "organism": "Rat", "refseq_name": "zinc finger protein 449 isoform 1", "refseq_ac": "NP_001420056", "gene_names_uniprotkb": "Zfp449; LOC684901", "gene_names_refseq": "Zfp449", "protein_names_uniprotkb": "Zinc finger protein 449", "protein_names_refseq": "zinc finger protein 449 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:684901)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007284 spermatogonial cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R5T3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R5T6-1", "uniprot_id": "M0R5T6_RAT", "mass": 52823.0, "length": 473, "protein_name": "Cysteine protease", "gene_name": "Atg4d", "organism": "Rat", "refseq_name": "cysteine protease ATG4D", "refseq_ac": "NP_001094483", "gene_names_uniprotkb": "Atg4d", "gene_names_refseq": "Atg4d", "protein_names_uniprotkb": "Cysteine protease; 3.4.22.-", "protein_names_refseq": "ATG4 autophagy related 4 homolog D; autophagy-related 4D; cysteine protease ATG4D", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:686505); (R-RNO-1632852)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.22.-", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity;GO:0070004 cysteine-type exopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006508 proteolysis;GO:0015031 protein transport;GO:0016485 protein processing;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R5T6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R5Y3-1", "uniprot_id": "M0R5Y3_RAT", "mass": 34662.0, "length": 308, "protein_name": "Olfactory receptor", "gene_name": "Or5b99", "organism": "Rat", "refseq_name": "olfactory receptor Olr346", "refseq_ac": "NP_001000255", "gene_names_uniprotkb": "Or5b99", "gene_names_refseq": "Olr346; Or5b99; ratchr1-216257071-216257997_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 346; olfactory receptor Olr346; olfactory receptor gene Olr346", "tax_id": 10116, "disease": "", "pathway": " (rno:293789)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R5Y3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R603-1", "uniprot_id": "M0R603_RAT", "mass": 32010.0, "length": 273, "protein_name": "Alkaline ceramidase", "gene_name": "Acer1", "organism": "Rat", "refseq_name": "alkaline ceramidase 1", "refseq_ac": "NP_001100345", "gene_names_uniprotkb": "Acer1", "gene_names_refseq": "Acer1; Asah3", "protein_names_uniprotkb": "Alkaline ceramidase; 3.5.1.-", "protein_names_refseq": "N-acylsphingosine amidohydrolase (alkaline ceramidase) 3; alkaline ceramidase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:301118); (R-RNO-9845614)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.-;3.5.1.23;3.5.1.60", "go_molecular_function": "GO:0046872 metal ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process;GO:0006672 ceramide metabolic process;GO:0048733 sebaceous gland development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R603-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R631-1", "uniprot_id": "M0R631_RAT", "mass": 46132.0, "length": 407, "protein_name": "AADACL4 family member 2", "gene_name": "Aadacl4fm2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Aadacl4fm2", "gene_names_refseq": "", "protein_names_uniprotkb": "AADACL4 family member 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:502999)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R631-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R685-1", "uniprot_id": "M0R685_RAT", "mass": 142108.0, "length": 1276, "protein_name": "Serine/threonine-protein kinase ULK4", "gene_name": "Ulk4", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase ULK4 isoform X1", "refseq_ac": "XP_038938659", "gene_names_uniprotkb": "Ulk4", "gene_names_refseq": "RGD1565726; Ulk4", "protein_names_uniprotkb": "Serine/threonine-protein kinase ULK4; 2.7.11.1; Unc-51-like kinase 4", "protein_names_refseq": "serine/threonine-protein kinase ULK4 isoform X1", "tax_id": 10116, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:363167)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005929 cilium", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007611 learning or memory;GO:0007613 memory;GO:0022010 central nervous system myelination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R685-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R6I9-1", "uniprot_id": "M0R6I9_RAT", "mass": 35213.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or6c74", "organism": "Rat", "refseq_name": "olfactory receptor Olr1064", "refseq_ac": "NP_001001076", "gene_names_uniprotkb": "Or6c74", "gene_names_refseq": "Olr1064; Or6c74", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1064; olfactory receptor 6C74-like; olfactory receptor 6C74; olfactory receptor Olr1064; olfactory receptor gene Olr1064", "tax_id": 10116, "disease": "", "pathway": " (rno:405966)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R6I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R6K3-1", "uniprot_id": "M0R6K3_RAT", "mass": 30786.0, "length": 283, "protein_name": "Proline rich 32", "gene_name": "Prr32", "organism": "Rat", "refseq_name": "proline-rich protein 32", "refseq_ac": "NP_001388135", "gene_names_uniprotkb": "Prr32; 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3.2.1.-", "protein_names_refseq": "lysozyme g-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:100910813)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a potent antibacterial protein that may play a role in the innate immunity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0009253 peptidoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R6U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R6Y6-1", "uniprot_id": "M0R6Y6_RAT", "mass": 40339.0, "length": 339, "protein_name": "Transmembrane protein 120B", "gene_name": "Tmem120b", "organism": "Rat", "refseq_name": "transmembrane protein 120B", "refseq_ac": "NP_001258238", "gene_names_uniprotkb": "Tmem120b; LOC690137", "gene_names_refseq": "Tmem120b", "protein_names_uniprotkb": "Transmembrane protein 120B", "protein_names_refseq": "transmembrane protein 120B", "tax_id": 10116, "disease": "", "pathway": " (rno:690137)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Necessary for efficient adipogenesis. Does not show ion channel activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0051291 protein heterooligomerization;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R6Y6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R6Z9-1", "uniprot_id": "M0R6Z9_RAT", "mass": 284315.0, "length": 2551, "protein_name": "Myosin XVIIIb", "gene_name": "Myo18b", "organism": "Rat", "refseq_name": "myosin XVIIIb", "refseq_ac": "NP_001419354", "gene_names_uniprotkb": "Myo18b", "gene_names_refseq": "Myo18b", "protein_names_uniprotkb": "Myosin XVIIIb", "protein_names_refseq": "myosin XVIIIb; unconventional myosin-XVIIIb-like; unconventional myosin-XVIIIb", "tax_id": 10116, "disease": "Klippel-Feil syndrome 4 (Disease Ontology:DOID:0080592)", "pathway": " (rno:304551)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0032982 myosin filament;GO:0030018 Z disc", "go_biological_process": "GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0055013 cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0R6Z9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R720-1", "uniprot_id": "M0R720_RAT", "mass": 35000.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or8c10b", "organism": "Rat", "refseq_name": "olfactory receptor Olr1229", "refseq_ac": "NP_001000444", "gene_names_uniprotkb": "Or8c10b", "gene_names_refseq": "Olr1229; Or8c10b; ratchr8-40485425-40486366_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1229; olfactory receptor 143-like; olfactory receptor Olr1229; olfactory receptor gene Olr1229", "tax_id": 10116, "disease": "", "pathway": " (rno:300554)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R720-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R7M4-1", "uniprot_id": "M0R7M4_RAT", "mass": 123253.0, "length": 1081, "protein_name": "RAD51 associated protein 2", "gene_name": "Rad51ap2", "organism": "Rat", "refseq_name": "RAD51-associated protein 2", "refseq_ac": "NP_001385983", "gene_names_uniprotkb": "Rad51ap2", "gene_names_refseq": "Rad51ap2", "protein_names_uniprotkb": "RAD51 associated protein 2", "protein_names_refseq": "RAD51-associated protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:100360197)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R7M4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R8K2-1", "uniprot_id": "M0R8K2_RAT", "mass": 13522.0, "length": 118, "protein_name": "Small nuclear ribonucleoprotein Sm D2", "gene_name": "Snrpd2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Snrpd2; SNRPD2", "gene_names_refseq": "", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein Sm D2; Sm-D2; snRNP core protein D2", "protein_names_refseq": "", "tax_id": 10116, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:1990446 U1 snRNP binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005829 cytosol;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0034715 pICln-Sm protein complex", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R8K2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R8R8-1", "uniprot_id": "M0R8R8_RAT", "mass": 46682.0, "length": 447, "protein_name": "Forkhead box F1", "gene_name": "Foxf1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Foxf1; 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Or7g23c", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1135; olfactory receptor 7G1-like; olfactory receptor 7G2-like; olfactory receptor Olr1135; olfactory receptor gene Olr1135", "tax_id": 10116, "disease": "", "pathway": " (rno:405177)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG., [UniProtKB, UniProtKB]; The effect of BMP9 on inflammation in the early stage of pulpitis. 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Involved in the control of myofibril assembly and stability at the Z lines in muscle cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051393 alpha-actinin binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030018 Z disc", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411 axon guidance;GO:0070593 dendrite self-avoidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RCF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0RCQ3-1", "uniprot_id": "M0RCQ3_RAT", "mass": 10125.0, "length": 90, "protein_name": "PIK3R3 upstream open reading frame", "gene_name": "P3r3urf", "organism": "Rat", "refseq_name": "P3R3URF protein", "refseq_ac": "NP_001386284", "gene_names_uniprotkb": "P3r3urf", "gene_names_refseq": "P3r3urf", "protein_names_uniprotkb": "PIK3R3 upstream open reading frame", "protein_names_refseq": "P3R3URF protein; 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LOC684259", "gene_names_refseq": "Rusc2", "protein_names_uniprotkb": "AP-4 complex accessory subunit RUSC2; Interacting protein of Rab1; RUN and SH3 domain-containing protein 2", "protein_names_refseq": "AP-4 complex accessory subunit RUSC2; iporin", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 61 (Disease Ontology:DOID:0080239)", "pathway": " (rno:684259)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RCV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0RCY9-1", "uniprot_id": "M0RCY9_RAT", "mass": 35137.0, "length": 315, "protein_name": "Olfactory receptor", "gene_name": "Or1j20", "organism": "Rat", "refseq_name": "olfactory receptor Olr415", "refseq_ac": "NP_001000386", "gene_names_uniprotkb": "Or1j20", "gene_names_refseq": "Olr415; Or1j20", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 415; olfactory receptor Olr415; olfactory receptor gene Olr415", "tax_id": 10116, "disease": "", "pathway": " (rno:296677)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RCY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0RD91-1", "uniprot_id": "M0RD91_RAT", "mass": 35893.0, "length": 317, "protein_name": "Olfactory receptor family 6 subfamily C member 202", "gene_name": "Or6c202", "organism": "Rat", "refseq_name": "olfactory receptor Olr954", "refseq_ac": "NP_001000703", "gene_names_uniprotkb": "Or6c202; Olr954", "gene_names_refseq": "Olr954; Or6c202", "protein_names_uniprotkb": "Olfactory receptor family 6 subfamily C member 202", "protein_names_refseq": "olfactory receptor 6C2-like; olfactory receptor 954; olfactory receptor Olr954; olfactory receptor gene Olr954", "tax_id": 10116, "disease": "", "pathway": " (rno:100911571)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RD91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0RDZ5-1", "uniprot_id": "M0RDZ5_RAT", "mass": 12249.0, "length": 113, "protein_name": "Ig-like domain-containing protein", "gene_name": "ENSRNOG00000066431", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ENSRNOG00000066431", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-173623); (R-RNO-198933); (R-RNO-202733); (R-RNO-2029481); (R-RNO-2029482); (R-RNO-2029485); (R-RNO-2168880); (R-RNO-2454202); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-2871837); (R-RNO-5690714); (R-RNO-977606); (R-RNO-983695)", "pathway_count": 15, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RDZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08769-1", "uniprot_id": "O08769_RAT", "mass": 22139.0, "length": 197, "protein_name": "Cyclin-dependent kinase inhibitor 1B", "gene_name": "Cdkn1b", "organism": "Rat", "refseq_name": "cyclin-dependent kinase inhibitor 1B", "refseq_ac": "NP_113950", "gene_names_uniprotkb": "Cdkn1b", "gene_names_refseq": "CDKN4; Cdki1b; Cdkn1b; Kip1; P27KIP1; p27", "protein_names_uniprotkb": "Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1", "protein_names_refseq": "Cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor p27/Kip1; cyclin-dependent kinase inhibitor p27", "tax_id": 10116, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); myelodysplastic syndrome (Disease Ontology:DOID:0050908); multiple endocrine neoplasia type 4 (Disease Ontology:DOID:0080137); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); sciatic neuropathy (Disease Ontology:DOID:11446); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); acute kidney failure (Disease Ontology:DOID:3021); multiple endocrine neoplasia (Disease Ontology:DOID:3125); pituitary adenoma (Disease Ontology:DOID:3829); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); infertility (Disease Ontology:DOID:5223); lung small cell carcinoma (Disease Ontology:DOID:5409); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); cataract (Disease Ontology:DOID:83); chronic myeloid leukemia (Disease Ontology:DOID:8552); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); senile cataract (Disease Ontology:DOID:9669); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:83571); (R-RNO-187577); (R-RNO-198323); (R-RNO-2559582); (R-RNO-2559586); (R-RNO-6804116); (R-RNO-69202); (R-RNO-69231); (R-RNO-69563); (R-RNO-69656); (R-RNO-8849470); (R-RNO-9634638)", "pathway_count": 12, "publication_count": 7, "publication_id_list": "22673903;26562163;32841050;33216476;33313941;34737126;37270133", "class_list": "", "function": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and ''cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats., [RefSeq, PubMed]; Down-Regulation of CK2alpha Leads toUp-Regulation of the Cyclin-Dependent Kinase Inhibitor p27(KIP1) in Conditions Unfavorable for the Growth of Myoblast Cells., [RefSeq, PubMed]; Exosomes from tannic acid-stimulated macrophages accelerate wound healing through miR-221-3p mediated fibroblasts migration by targeting CDKN1b., [RefSeq, PubMed]; GAS5 regulates diabetic cardiomyopathy via miR2213p/p27 axisassociated autophagy., [RefSeq, PubMed]; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry., [UniProtKB, UniProtKB, UniProtKB]; Role of EBAF/Nodal/p27 signaling pathway in development of placenta in normal and diabetic rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 0, "mined_o_glycosites": 2, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 30, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0030332 cyclin binding;GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0031464 Cul4A-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0007165 signal transduction;GO:0050680 negative regulation of epithelial cell proliferation;GO:0045930 negative regulation of mitotic cell cycle;GO:0000082 G1/S transition of mitotic cell cycle;GO:1901990 regulation of mitotic cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08769-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35370-1", "uniprot_id": "O35370_RAT", "mass": 61845.0, "length": 577, "protein_name": "Thrombomodulin", "gene_name": "Thbd", "organism": "Rat", "refseq_name": "thrombomodulin precursor", "refseq_ac": "NP_113959", "gene_names_uniprotkb": "Thbd", "gene_names_refseq": "Thbd", "protein_names_uniprotkb": "Thrombomodulin", "protein_names_refseq": "thrombomdulin; thrombomodulin precursor", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); thrombophilia due to thrombomodulin defect (Disease Ontology:DOID:0111908); brain small vessel disease (Disease Ontology:DOID:0112313); dermatomyositis (Disease Ontology:DOID:10223); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); familial combined hyperlipidemia (Disease Ontology:DOID:13809); hypothyroidism (Disease Ontology:DOID:1459); impotence (Disease Ontology:DOID:1875); thrombophilia (Disease Ontology:DOID:2452); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); familial Mediterranean fever (Disease Ontology:DOID:2987); acute kidney failure (Disease Ontology:DOID:3021); ischemia (Disease Ontology:DOID:326); coronary artery disease (Disease Ontology:DOID:3393); carotid artery thrombosis (Disease Ontology:DOID:3410); cerebral infarction (Disease Ontology:DOID:3526); lung non-small cell carcinoma (Disease Ontology:DOID:3908); liver disease (Disease Ontology:DOID:409); pulmonary hypertension (Disease Ontology:DOID:6432); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:83580); (R-RNO-202733); (R-RNO-9769739)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "25109347;26923576", "class_list": "", "function": "Cellular and soluble levels of thrombomodulin are modified by cold stress in healthy rats, possibly via catecholamines and HSF1., [RefSeq, PubMed]; Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response., [UniProtKB, UniProtKB]; This study demonstrated that Thbd increases in male rat with aneurysmal subarachnoid hemorrhage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6K7B7", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005509 calcium ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0007596 blood coagulation;GO:0007565 female pregnancy;GO:0030195 negative regulation of blood coagulation;GO:0051591 response to cAMP", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35370-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35977-1", "uniprot_id": "O35977_RAT", "mass": 51669.0, "length": 464, "protein_name": "GDNF family receptor alpha-2", "gene_name": "Gfra2", "organism": "Rat", "refseq_name": "GDNF family receptor alpha-2", "refseq_ac": "NP_036882", "gene_names_uniprotkb": "Gfra2", "gene_names_refseq": "Gfra2; Retl2", "protein_names_uniprotkb": "GDNF family receptor alpha-2; GDNF receptor alpha-2", "protein_names_refseq": "GDNF family receptor alpha-2; glial cell line derived neurotrophic factor family receptor alpha 2; tyrosine kinase receptor ligand 2", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855)", "pathway": " (rno:25136); (R-RNO-5673001); (R-RNO-8853659)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "18085594;18184180;21723942;22266674;29393594", "class_list": "", "function": "Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms., [RefSeq, PubMed]; GAP43 mRNA expression moderately increased in the intact Major pelvic ganglia, and GFRalpha2 mRNA was maintained in the intact MPG but not in the injured one., [RefSeq, PubMed]; GFRalpha2-labeled fibers were only in inner lamina II of spinal cord., [RefSeq, PubMed]; Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Synthesis of GFRa2 protein is enhanced in Muller cells at 24 hr in experimental diabetic retinopathy, and then the level of GFRa2 protein is downregulated., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6HTN1", "ec_number_list": "", "go_molecular_function": "GO:1904399 heparan sulfate binding;GO:0016167 glial cell-derived neurotrophic factor receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0031953 negative regulation of protein autophosphorylation;GO:1904894 positive regulation of receptor signaling pathway via STAT", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35977-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88996-1", "uniprot_id": "O88996_RAT", "mass": 20820.0, "length": 193, "protein_name": "Bcl-2-like protein 2", "gene_name": "Bcl2l2", "organism": "Rat", "refseq_name": "bcl-2-like protein 2", "refseq_ac": "NP_068622", "gene_names_uniprotkb": "Bcl2l2", "gene_names_refseq": "BCL-WEL; BCL-WS; BCL-W; Bcl2l2; Bclw", "protein_names_uniprotkb": "Bcl-2-like protein 2; Apoptosis regulator Bcl-W", "protein_names_refseq": "bcl-2-like protein 2", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); Burkitt lymphoma (Disease Ontology:DOID:8584)", "pathway": " (rno:60434)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "33128129;35894779", "class_list": "", "function": "MiR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells., [RefSeq, PubMed]; Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells., [RefSeq, PubMed]; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015267 channel activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0097718 disordered domain specific binding;GO:0051400 BH domain binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031966 mitochondrial membrane;GO:0097136 Bcl-2 family protein complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0001836 release of cytochrome c from mitochondria;GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand;GO:0008406 gonad development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88996-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1RP75-1", "uniprot_id": "Q1RP75_RAT", "mass": 23225.0, "length": 197, "protein_name": "rRNA-processing protein FCF1 homolog", "gene_name": "Fcf1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fcf1", "gene_names_refseq": "", "protein_names_uniprotkb": "rRNA-processing protein FCF1 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:299198); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RP75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q32KK2-1", "uniprot_id": "Q32KK2_RAT", "mass": 53732.0, "length": 507, "protein_name": "Arylsulfatase A", "gene_name": "Arsa", "organism": "Rat", "refseq_name": "arylsulfatase A precursor", "refseq_ac": "NP_001030105", "gene_names_uniprotkb": "Arsa", "gene_names_refseq": "Arsa", "protein_names_uniprotkb": "Arylsulfatase A; 3.1.6.8; Cerebroside-sulfatase", "protein_names_refseq": "arylsulfatase A precursor", "tax_id": 10116, "disease": "metachromatic leukodystrophy (Disease Ontology:DOID:10581); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (rno:315222); (R-RNO-1663150); (R-RNO-6798695); (R-RNO-9840310)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes cerebroside sulfate., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.2.2;3.4.21.4;3.4.16.-;3.2.1.-;5.3.4.1;1.1.1.205;3.2.1.23;1.8.3.7;5.3.99.3;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.17;3.2.1.31;3.5.3.1;2.7.11.13;3.1.6.2;2.3.3.8;3.2.1.51;3.4.21.20;1.6.2.2;3.5.3.15;3.5.1.26;3.6.4.6;3.1.6.12;2.4.1.1;2.7.11.24;3.1.27.-;3.4.14.1;3.1.6.1;3.1.6.18;3.1.6.4;3.1.6.-;3.1.6.15;3.1.6.8;1.6.5.5;3.6.1.-;2.7.10.2;3.4.19.9;3.1.3.16;3.2.1.52;6.3.4.21;3.4.14.2", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004065 arylsulfatase activity;GO:0004098 cerebroside-sulfatase activity;GO:0008484 sulfuric ester hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007339 binding of sperm to zona pellucida;GO:0007584 response to nutrient;GO:0045471 response to ethanol;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32KK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q32PX6-1", "uniprot_id": "Q32PX6_RAT", "mass": 21309.0, "length": 191, "protein_name": "Rho-related GTP-binding protein RhoG", "gene_name": "Rhog", "organism": "Rat", "refseq_name": "rho-related GTP-binding protein RhoG", "refseq_ac": "NP_001032272", "gene_names_uniprotkb": "Rhog", "gene_names_refseq": "Arhg; Rhog", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoG", "protein_names_refseq": "ras homolog gene family, member G (rho G); rho-related GTP-binding protein RhoG", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:308875); (R-RNO-114604); (R-RNO-1257604); (R-RNO-5625970); (R-RNO-6798695); (R-RNO-6811558); (R-RNO-9013408)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "12393274;19581409;22588079;22734669;27412363;27662902", "class_list": "", "function": "Dock3 forms a complex with Elmo and activated RhoG downstream of BDNF-TrkB signaling and induces neurite outgrowth via Rac1 activation in PC12 cells., [RefSeq, PubMed]; Fibroblast growth factor 2-induced Rac1 activation depends on the suppression of RhoG by a previously uncharacterized ternary S4-synectin-RhoGDI1 protein complex and activation via PKCalpha., [RefSeq, PubMed]; Plays a role in immunological synaptic F-actin density and architecture organization. Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity. Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells. Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D. Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells., [UniProtKB, UniProtKB]; RHOG can mediate signaling through downstream effectors DOCK1 and RAC1 during ovarian follicular development (theca and granulosa cells and oocyte), but dehydroepiandrosterone downregulated them in the polycystic ovarian syndrome ovary., [RefSeq, PubMed]; Rac1, Cdc42, and RhoG perform very specific and non-redundant functions at different levels of hierarchy in regulating dendritic tree complexity induced by CALEB/NGC, [RefSeq, PubMed]; Results suggest distinct pre- and postnatal roles in the development of the central nervous system, [RefSeq, PubMed]; RhoG emerges as a cellular conductor of Rac1 and Cdc42 activity, in turn regulated by miR-124 to control axonal and dendritic branching., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0098794 postsynapse", "go_biological_process": "GO:1900027 regulation of ruffle assembly;GO:0007015 actin filament organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q32PX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4G079-1", "uniprot_id": "Q4G079_RAT", "mass": 35401.0, "length": 321, "protein_name": "Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1", "gene_name": "Aimp1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Aimp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy 3 (Disease Ontology:DOID:0060790); neurodegenerative disease (Disease Ontology:DOID:1289); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:114632)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34502162", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6HVT5", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000049 tRNA binding;GO:0005125 cytokine activity;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0009986 cell surface;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0051607 defense response to virus;GO:0048514 blood vessel morphogenesis;GO:0001937 negative regulation of endothelial cell proliferation;GO:0050900 leukocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4G079-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KLK7-1", "uniprot_id": "Q4KLK7_RAT", "mass": 65399.0, "length": 588, "protein_name": "Nucleolar protein 56", "gene_name": "Nop56", "organism": "Rat", "refseq_name": "nucleolar protein 56", "refseq_ac": "NP_001020903", "gene_names_uniprotkb": "Nop56", "gene_names_refseq": "Nol5a; Nop56", "protein_names_uniprotkb": "Nucleolar protein 56; Nucleolar protein 5A", "protein_names_refseq": "NOP56 ribonucleoprotein homolog; nucleolar protein 56; nucleolar protein 5A", "tax_id": 10116, "disease": "spinocerebellar ataxia 36 (Disease Ontology:DOID:0050983)", "pathway": " (rno:362214); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16396499;22673903;24013231", "class_list": "", "function": "Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs)., [UniProtKB, UniProtKB]; Nol5a expands the link between Myc-induced regulation of nucleolar target genes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0030515 snoRNA binding;GO:1990226 histone methyltransferase binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0070761 pre-snoRNP complex;GO:0031428 box C/D methylation guide snoRNP complex;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex", "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4KLK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KM07-1", "uniprot_id": "Q4KM07_RAT", "mass": 62403.0, "length": 552, "protein_name": "Integral membrane transport protein UST5r", "gene_name": "Ust5r", "organism": "Rat", "refseq_name": "solute carrier family 22 member 30", "refseq_ac": "NP_599207", "gene_names_uniprotkb": "Ust5r", "gene_names_refseq": "Slc22a30; Slc22a9; Ust5r", "protein_names_uniprotkb": "Integral membrane transport protein UST5r", "protein_names_refseq": "integral membrane transport protein UST5r; solute carrier family 22 member 30; solute carrier family 22 member 9", "tax_id": 10116, "disease": "", "pathway": " (rno:171398)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F7F2E0", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015711 organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KM07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7E3-1", "uniprot_id": "Q4V7E3_RAT", "mass": 26153.0, "length": 235, "protein_name": "Zinc finger, BED-type containing 3", "gene_name": "Zbed3", "organism": "Rat", "refseq_name": "zinc finger BED domain-containing protein 3", "refseq_ac": "NP_001020900", "gene_names_uniprotkb": "Zbed3", "gene_names_refseq": "Zbed3", "protein_names_uniprotkb": "Zinc finger, BED-type containing 3", "protein_names_refseq": "zinc finger BED domain-containing protein 3; zinc finger, BED domain containing 3", "tax_id": 10116, "disease": "", "pathway": " (rno:361881)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6I4Y7", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0051293 establishment of spindle localization;GO:0007015 actin filament organization;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001933 negative regulation of protein phosphorylation;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7E3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7G0-1", "uniprot_id": "Q4V7G0_RAT", "mass": 18622.0, "length": 164, "protein_name": "T-cell surface glycoprotein CD3 zeta chain", "gene_name": "Cd247", "organism": "Rat", "refseq_name": "T-cell surface glycoprotein CD3 zeta chain isoform 1", "refseq_ac": "NP_740770", "gene_names_uniprotkb": "Cd247", "gene_names_refseq": "Cd247; Cd3z; TCRzeta", "protein_names_uniprotkb": "T-cell surface glycoprotein CD3 zeta chain; T-cell receptor T3 zeta chain", "protein_names_refseq": "CD247 antigen; CD3 antigen, zeta polypeptide; T-cell receptor CD3, subunit zeta; T-cell surface glycoprotein CD3 zeta chain isoform 1; T-cell surface glycoprotein CD3 zeta chain", "tax_id": 10116, "disease": "immunodeficiency 25 (Disease Ontology:DOID:0111942)", "pathway": " (rno:25300); (R-RNO-198933); (R-RNO-202424); (R-RNO-202427); (R-RNO-202430); (R-RNO-202433); (R-RNO-389948)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "21809042;22673903;24343121;28669876", "class_list": "", "function": "Ectopic CD3zeta expression in neural precursor stem cells impaired their normal cell-fate specification. Variations of CD3zeta expression in the developing CNS might result in neurodevelopmental anomalies., [RefSeq, PubMed]; Functional T cells are required for the full development of Dahl salt-sensitive hypertension and indicate that the association between CD247 and hypertension in humans may be related to altered immune cell function., [RefSeq, PubMed]; In the original motor cortical representations of the brachial plexus, mRNA and protein expression levels of MHCI, PirB, and CD3zeta were down-regulated 7 days post brachial plexus injury compared with control. Interestingly, mRNA and protein expression levels of these factors were up-regulated at 3 months compared with 7 days, excepting PirB protein, whose expression was not increasing., [RefSeq, PubMed]; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD247/CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0042101 T cell receptor complex;GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "GO:0038094 Fc-gamma receptor signaling pathway;GO:0007166 cell surface receptor signaling pathway;GO:0051259 protein complex oligomerization;GO:2000010 positive regulation of protein localization to cell surface;GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4V7G0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BK56-1", "uniprot_id": "GSTM4_RAT", "mass": 25553.0, "length": 218, "protein_name": "Glutathione S-transferase Mu 4", "gene_name": "Gstm4", "organism": "Rat", "refseq_name": "glutathione S-transferase Mu 4", "refseq_ac": "NP_001019475", "gene_names_uniprotkb": "Gstm4", "gene_names_refseq": "GSTM4-4; Gstm4", "protein_names_uniprotkb": "Glutathione S-transferase Mu 4; 2.5.1.18; 4.4.1.20; GST class-mu 4; GSTM4-4; Leukotriene C4 synthase GSTM4", "protein_names_refseq": "GST class-mu 4; glutathione S-transferase M4; glutathione S-transferase Mu 4; glutathione S-transferase mu 3; leukotriene C4 synthase GSTM4", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:499689); (R-RNO-156590); (R-RNO-9026762)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.18;1.11.1.-;4.4.1.20;5.3.99.2;5.3.3.-;5.2.1.2;1.20.4.2;1.8.5.1;2.5.1.-;5.3.99.3", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0004464 leukotriene-C4 synthase activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0042759 long-chain fatty acid biosynthetic process;GO:0006749 glutathione metabolic process;GO:0018916 nitrobenzene metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5EB90-1", "uniprot_id": "Q5EB90_RAT", "mass": 31443.0, "length": 275, "protein_name": "DNA-directed RNA polymerase II subunit RPB3", "gene_name": "Polr2c", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerase II subunit RPB3", "refseq_ac": "NP_001012491", "gene_names_uniprotkb": "Polr2c", "gene_names_refseq": "Polr2c", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB3; DNA-directed RNA polymerase II 33 kDa polypeptide; DNA-directed RNA polymerase II subunit C; RPB31", "protein_names_refseq": "DNA-directed RNA polymerase II subunit RPB3; polymerase (RNA) II (DNA directed) polypeptide C, 33kDa; polymerase (RNA) II subunit C; polymerase II polypeptide C", "tax_id": 10116, "disease": "", "pathway": " (rno:361365); (R-RNO-112382); (R-RNO-113418); (R-RNO-5578749); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-6803529); (R-RNO-6807505); (R-RNO-72086); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075); (R-RNO-9018519); (R-RNO-9770562)", "pathway_count": 23, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005665 RNA polymerase II, core complex;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5EB90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FAQ9-1", "uniprot_id": "Q5FAQ9_RAT", "mass": 38833.0, "length": 340, "protein_name": "Ras association domain-containing protein 1", "gene_name": "Rassf1", "organism": "Rat", "refseq_name": "ras association domain-containing protein 1 isoform 1", "refseq_ac": "NP_001032644", "gene_names_uniprotkb": "Rassf1", "gene_names_refseq": "Rassf1", "protein_names_uniprotkb": "Ras association domain-containing protein 1", "protein_names_refseq": "Ras association (RalGDS/AF-6) domain family 1; Ras association (RalGDS/AF-6) domain family member 1; Ras association domain family 1; ras association domain-containing protein 1 isoform 1; ras association domain-containing protein 1", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "21565688;21938476;24945829;26401643;31595551", "class_list": "", "function": "Apoptotic Ras effector molecules RASSF1 and NORE1 play important role in NGF reduction and TNF-alpha-related pancreatic beta cell apoptosis in hyperglycemic rats., [RefSeq, PubMed]; DNMT3A and RASSF1A may serve as a new mechanism for cardiac fibrosis., [RefSeq, PubMed]; RASSF1 promotes cardiomyocyte apoptosis after acute myocardial infarction and is regulated by miR-125b., [RefSeq, PubMed]; The results suggest a previously unknown mechanism of HDAC6 inactivation of RASSF1A controls cardiac fibroblast proliferation and fibrosis., [RefSeq, PubMed]; These findings suggest that loss of function or decrease of RAR-beta2, RASSF1A, and CDKN2A, as well as the hypermethylation of 5' region of these genes, are related with nickel exposure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1M9A9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006974 DNA damage response;GO:0007265 Ras protein signal transduction;GO:0050821 protein stabilization;GO:0031398 positive regulation of protein ubiquitination;GO:1902806 regulation of cell cycle G1/S phase transition", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5FAQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I0E5-1", "uniprot_id": "CLD18_RAT", "mass": 27922.0, "length": 261, "protein_name": "Claudin-18", "gene_name": "Cldn18", "organism": "Rat", "refseq_name": "claudin-18 precursor", "refseq_ac": "NP_001014118", "gene_names_uniprotkb": "Cldn18", "gene_names_refseq": "Cldn18", "protein_names_uniprotkb": "Claudin-18", "protein_names_refseq": "claudin-18 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:315953)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;24787463", "class_list": "", "function": "Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (PubMed:24787463). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity)., [UniProtKB, UniProtKB, PubMed]; Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6A5Z5;F1LNR6", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0070160 tight junction", "go_biological_process": "GO:0120192 tight junction assembly;GO:0042045 epithelial fluid transport;GO:0045471 response to ethanol;GO:0048286 lung alveolus development;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5I0E5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5J3E9-1", "uniprot_id": "Q5J3E9_RAT", "mass": 35793.0, "length": 311, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vom1r15", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Vom1r15; LOC120098104; Vom1r10", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:494305)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5J3E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5J3H4-1", "uniprot_id": "Q5J3H4_RAT", "mass": 36318.0, "length": 317, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vom1r61", "organism": "Rat", "refseq_name": "vomeronasal 1 receptor 61", "refseq_ac": "NP_001008935", "gene_names_uniprotkb": "Vom1r61", "gene_names_refseq": "V1rj3; Vom1r61", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vom1r61; vomeronasal 1 receptor 61; vomeronasal 1 receptor, J3; vomeronasal V1r-type receptor V1rj3; vomeronasal type-1 receptor 90", "tax_id": 10116, "disease": "", "pathway": " (rno:494282)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5J3H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5J3H7-1", "uniprot_id": "Q5J3H7_RAT", "mass": 37704.0, "length": 332, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vom1r37", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Vom1r37", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5J3H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5J3I1-1", "uniprot_id": "Q5J3I1_RAT", "mass": 34255.0, "length": 299, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vom1r72", "organism": "Rat", "refseq_name": "vomeronasal 1 receptor 72", "refseq_ac": "NP_001009521", "gene_names_uniprotkb": "Vom1r72", "gene_names_refseq": "V1rc39; Vom1r72", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vom1r72; vomeronasal 1 receptor 72; vomeronasal 1 receptor, C39; vomeronasal V1r-type receptor V1rc39; vomeronasal type-1 receptor 100", "tax_id": 10116, "disease": "", "pathway": " (rno:494241)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, 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Publication Status: Online-Only, [RefSeq, PubMed]; Duration of Reduction in Enduring Stress-Induced Hyperalgesia Via FKBP51 Inhibition Depends on Timing of Administration Relative to Traumatic Stress Exposure., [RefSeq, PubMed]; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production., [UniProtKB, UniProtKB]; Regulatory Effects of Maternal Immune Activation and Environmental Enrichment on Glucocorticoid Receptor and FKBP5 Expression in Stress-sensitive Regions of the Offspring Brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I5ZX46;F7EYK0", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5U2T9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIQ7-1", "uniprot_id": "Q5XIQ7_RAT", "mass": 44427.0, "length": 393, "protein_name": "Heat shock transcription factor, Y linked 2", "gene_name": "Hsfy2", "organism": "Rat", "refseq_name": "heat shock transcription factor, Y linked 2", "refseq_ac": "NP_001012132", "gene_names_uniprotkb": "Hsfy2", "gene_names_refseq": "Hsfy1; Hsfy2", "protein_names_uniprotkb": "Heat shock transcription factor, Y linked 2", "protein_names_refseq": "heat shock transcription factor, Y linked 2; heat shock transcription factor, Y-linked 1", "tax_id": 10116, "disease": "", "pathway": " (rno:316409)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIQ8-1", "uniprot_id": "Q5XIQ8_RAT", "mass": 85344.0, "length": 770, "protein_name": "Hexosyltransferase", "gene_name": "Chpf", "organism": "Rat", "refseq_name": "chondroitin sulfate synthase 2", "refseq_ac": "NP_001005906", "gene_names_uniprotkb": "Chpf", "gene_names_refseq": "Chpf; D1bwg1363e", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "chondroitin sulfate synthase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:316533); (R-RNO-2022870)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIT8-1", "uniprot_id": "Q5XIT8_RAT", "mass": 22433.0, "length": 210, "protein_name": "Claudin", "gene_name": "Cldn4", "organism": "Rat", "refseq_name": "claudin-4", "refseq_ac": "NP_001012022", "gene_names_uniprotkb": "Cldn4", "gene_names_refseq": "Cldn4", "protein_names_uniprotkb": "Claudin", "protein_names_refseq": "claudin-4", "tax_id": 10116, "disease": "peptic esophagitis (Disease Ontology:DOID:13976); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (rno:304407)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15602007;29179201;29393594;33343804;37866316;38477100", "class_list": "", "function": "Both upregulation of claudin-4 and downregulation of occludin might increase paracellular NaCl transport in the kidney, resulting in impaired pressure natriuresis in SS rats., [RefSeq, PubMed]; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]; Cldn4 overexpression promotes penile cavernous smooth muscle cell fibrotic response via the JNK signaling pathway., [RefSeq, PubMed]; Clostridium enterotoxin enhances the absorption of dextran in rat jejunum, apparently through interactions with claudin-4., [RefSeq, PubMed]; Hypoxic bone marrow mesenchymal stem cell-derived exosomal lncRNA XIST attenuates lipopolysaccharide-induced acute lung injury via the miR-455-3p/Claudin-4 axis., [RefSeq, PubMed]; Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6J0G5", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0045471 response to ethanol;GO:0061436 establishment of skin barrier;GO:0007565 female pregnancy;GO:0032570 response to progesterone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5XIT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63395-1", "uniprot_id": "Q63395_RAT", "mass": 34474.0, "length": 309, "protein_name": "Olfactory receptor", "gene_name": "Olr1271", "organism": "Rat", "refseq_name": "olfactory receptor Olr1271", "refseq_ac": "NP_775422", "gene_names_uniprotkb": "Olr1271", "gene_names_refseq": "Olp4; Olr1271", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "odorant receptor; olfactory receptor Olr1271; olfactory receptor gene Olr1271; olfactory receptor olp4", "tax_id": 10116, "disease": "", "pathway": " (rno:286959)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M0RC64;M0RD01", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q63395-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q641Z9-1", "uniprot_id": "Q641Z9_RAT", "mass": 18203.0, "length": 169, "protein_name": "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial", "gene_name": "Sdhc", "organism": "Rat", "refseq_name": "succinate dehydrogenase cytochrome b560 subunit, mitochondrial", "refseq_ac": "NP_001005534", "gene_names_uniprotkb": "Sdhc", "gene_names_refseq": "Sdhc", "protein_names_uniprotkb": "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Integral membrane protein CII-3; Malate dehydrogenase [quinone] cytochrome b560 subunit; QPs-1", "protein_names_refseq": "succinate dehydrogenase complex, subunit C, integral membrane protein; succinate dehydrogenase cytochrome b560 subunit, mitochondrial", "tax_id": 10116, "disease": "paraganglioma (Disease Ontology:DOID:0050773); pheochromocytoma/paraganglioma syndrome 3 (Disease Ontology:DOID:0061218); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); Leigh disease (Disease Ontology:DOID:3652); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (rno:289217); (R-RNO-71403); (R-RNO-9854311)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0043495 protein-membrane adaptor activity;GO:0008177 succinate dehydrogenase (quinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0045273 respiratory chain complex II (succinate dehydrogenase);GO:0016020 membrane", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q641Z9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H77-1", "uniprot_id": "Q66H77_RAT", "mass": 62286.0, "length": 555, "protein_name": "Solute carrier family 22 member 22", "gene_name": "Slc22a22", "organism": "Rat", "refseq_name": "solute carrier family 22 member 22 isoform 1", "refseq_ac": "NP_001013969", "gene_names_uniprotkb": "Slc22a22", "gene_names_refseq": "RGD1304605; Slc22a22; oat-pg", "protein_names_uniprotkb": "Solute carrier family 22 member 22", "protein_names_refseq": "prostaglandin transporter OAT-PG; solute carrier family 22 (organic cation transporter), member 22; solute carrier family 22 member 22 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:299944)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22031854", "class_list": "", "function": "OAT-PG is involved in local PGE(2) clearance in the renal cortex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004955 prostaglandin receptor activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015711 organic anion transport;GO:0071720 sodium-independent prostaglandin transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H79-1", "uniprot_id": "Q66H79_RAT", "mass": 72154.0, "length": 655, "protein_name": "E3 ubiquitin-protein ligase TRIM32", "gene_name": "Trim32", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM32", "refseq_ac": "NP_001012103", "gene_names_uniprotkb": "Trim32", "gene_names_refseq": "Trim32", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM32; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM32; Tripartite motif-containing protein 32", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM32; tripartite motif protein 32", "tax_id": 10116, "disease": "Bardet-Biedl syndrome 11 (Disease Ontology:DOID:0110133); autosomal recessive limb-girdle muscular dystrophy type 2H (Disease Ontology:DOID:0110282); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:313264); (R-RNO-3134975); (R-RNO-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "28025799;28933219;31410708;31967859;34888944", "class_list": "", "function": "After sciatic nerve crush, TRIM32 expression is rapidly increased along with neurite outgrowth., [RefSeq, PubMed]; Knockdown of TRIM32 protects hippocampal neurons from oxygen-glucose deprivation-induced oxidative injury through activation of the Nrf2 signaling pathway., [RefSeq, PubMed]; Suppression of Trim32 promotes the recovery of neurological function after traumatic brain injury., [RefSeq, PubMed]; TRIM32 promotes inflammatory factor-induced apoptosis of nucleus pulposus cells, in part by degradation of AXIN1 to trigger Beta-catenin signaling., [RefSeq, PubMed]; Ubiquitin ligase TRIM32 promotes dendrite arborization by mediating degradation of the epigenetic factor CDYL., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6J801", "ec_number_list": "2.3.2.26;2.3.2.32;2.3.2.31;2.3.2.23;2.3.2.27;2.3.2.34;2.3.2.24;2.3.2.-;2.3.2.25", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005776 autophagosome;GO:0005863 striated muscle myosin thick filament", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:1902018 negative regulation of cilium assembly;GO:0044790 suppression of viral release by host;GO:0007014 actin ubiquitination;GO:1903883 positive regulation of interleukin-17-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q66H79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FQ1-1", "uniprot_id": "Q68FQ1_RAT", "mass": 73020.0, "length": 639, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Zswim2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zswim2", "gene_names_refseq": "", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27; MEKK1-related protein X; ZZ-type zinc finger-containing protein 2; Zinc finger SWIM domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:296455)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PTV6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "", "go_biological_process": "GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6MFW7-1", "uniprot_id": "Q6MFW7_RAT", "mass": 34198.0, "length": 309, "protein_name": "Olfactory receptor", "gene_name": "Or1o2e", "organism": "Rat", "refseq_name": "olfactory receptor 1739", "refseq_ac": "NP_001001423", "gene_names_uniprotkb": "Or1o2e", "gene_names_refseq": "MOR156-2b; Olr1739; Or11; Or1o2e", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 11; olfactory receptor 1739; olfactory receptor gene Olr1739", "tax_id": 10116, "disease": "", "pathway": " (rno:405202)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6MFW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6MG20-1", "uniprot_id": "Q6MG20_RAT", "mass": 52211.0, "length": 463, "protein_name": "General transcription factor IIH subunit 4", "gene_name": "Gtf2h4", "organism": "Rat", "refseq_name": "general transcription factor IIH subunit 4", "refseq_ac": "NP_997666", "gene_names_uniprotkb": "Gtf2h4", "gene_names_refseq": "Gtf2h4", "protein_names_uniprotkb": "General transcription factor IIH subunit 4", "protein_names_refseq": "TFIIH transcription/DNA repair factor p52 subunit; general transcription factor II H, polypeptide 4; general transcription factor IIH subunit 4", "tax_id": 10116, "disease": "", "pathway": " (rno:294236)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA., [UniProtKB, UniProtKB]; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001671 ATPase activator activity;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005675 transcription factor TFIIH holo complex;GO:0005669 transcription factor TFIID complex;GO:0000438 core TFIIH complex portion of holo TFIIH complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6MG20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P780-1", "uniprot_id": "Q6P780_RAT", "mass": 39129.0, "length": 365, "protein_name": "NF-kappa-B inhibitor epsilon", "gene_name": "Nfkbie", "organism": "Rat", "refseq_name": "NF-kappa-B inhibitor epsilon", "refseq_ac": "NP_954542", "gene_names_uniprotkb": "Nfkbie", "gene_names_refseq": "Nfkbie; Slc35b2", "protein_names_uniprotkb": "NF-kappa-B inhibitor epsilon; I-kappa-B-epsilon", "protein_names_refseq": "NF-kappa-B inhibitor epsilon; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon; solute carrier family 35, member B2", "tax_id": 10116, "disease": "collagen disease (Disease Ontology:DOID:854)", "pathway": " (rno:316241); (R-RNO-1169091)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16277611", "class_list": "", "function": "D-serine modulator-1 is the rat orthologue of the human 3'-phosphoadenosine 5'-phosphosulfate transporter 1 gene, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0042942 D-serine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P780-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6QI30-1", "uniprot_id": "Q6QI30_RAT", "mass": 17671.0, "length": 158, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6QI30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZMA0-1", "uniprot_id": "Q6ZMA0_RAT", "mass": 36236.0, "length": 321, "protein_name": "Olfactory receptor", "gene_name": "Or12d17", "organism": "Rat", "refseq_name": "olfactory receptor family 12 subfamily D member 17", "refseq_ac": "NP_998896", "gene_names_uniprotkb": "Or12d17", "gene_names_refseq": "MOR250-1; Olr1868; Or12d17; Or29", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1868; olfactory receptor 29; olfactory receptor family 12 subfamily D member 17", "tax_id": 10116, "disease": "", "pathway": " (rno:408030)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6ZMA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQ59-1", "uniprot_id": "Q7TQ59_RAT", "mass": 29780.0, "length": 264, "protein_name": "Seminal vesicle secretory protein 3A", "gene_name": "Svs3a", "organism": "Rat", "refseq_name": "seminal vesicle secretory protein 3A precursor", "refseq_ac": "NP_001007606", "gene_names_uniprotkb": "Svs3a", "gene_names_refseq": "Svs3a; Svs3", "protein_names_uniprotkb": "Seminal vesicle secretory protein 3A", "protein_names_refseq": "androgen-responsive protein pSv-1; seminal vesicle secretion 3 alpha; seminal vesicle secretory protein 2-like; seminal vesicle secretory protein 3A precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:192239)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15582586", "class_list": "", "function": "Six peptide sequences determined from the trypsin digests of RSVS III were confirmed in the protein sequence derived from two paralogs, RSVS III(alpha) and RSVS III(beta) gene, in rat 3q42 [RSVS III(alpha) and RSVS III(beta)], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:1901318 negative regulation of flagellated sperm motility;GO:0048240 sperm capacitation;GO:0050817 coagulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQ59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VT8-1", "uniprot_id": "Q80VT8_RAT", "mass": 10910.0, "length": 92, "protein_name": "S100 calcium-binding protein, ventral prostate", "gene_name": "S100vp", "organism": "Rat", "refseq_name": "S100 calcium-binding protein, ventral prostate", "refseq_ac": "NP_788265", "gene_names_uniprotkb": "S100vp", "gene_names_refseq": "S100RVP; S100vp", "protein_names_uniprotkb": "S100 calcium-binding protein, ventral prostate", "protein_names_refseq": "S100 calcium-binding protein, ventral prostate", "tax_id": 10116, "disease": "", "pathway": " (rno:295176)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16444689", "class_list": "", "function": "The results of this study argue for a role of S100RVP in calcium homeostasis in the prostate, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0033574 response to testosterone", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80VT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4B1-1", "uniprot_id": "Q8K4B1_RAT", "mass": 14266.0, "length": 125, "protein_name": "C-X-C motif chemokine", "gene_name": "Cxcl9", "organism": "Rat", "refseq_name": "C-X-C motif chemokine 9 precursor", "refseq_ac": "NP_663705", "gene_names_uniprotkb": "Cxcl9", "gene_names_refseq": "Cxcl9; Mig; Scyb9", "protein_names_uniprotkb": "C-X-C motif chemokine", "protein_names_refseq": "C-X-C motif chemokine 9 precursor; C-X-C motif chemokine 9; chemokine (C-X-C motif) ligand 9; monokine induced by gamma interferon; small inducible cytokine B9", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); pulmonary sarcoidosis (Disease Ontology:DOID:13406); thoracic aortic aneurysm (Disease Ontology:DOID:14004); cystic fibrosis (Disease Ontology:DOID:1485); bronchiolitis obliterans (Disease Ontology:DOID:2799); severe acute respiratory syndrome (Disease Ontology:DOID:2945); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); pneumonia (Disease Ontology:DOID:552); extrinsic allergic alveolitis (Disease Ontology:DOID:841); chronic fatigue syndrome (Disease Ontology:DOID:8544); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:246759); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "35548957", "class_list": "", "function": "Ursolic acid inhibits Th17 cell differentiation via STAT3/RORgammat pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6KK93", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding;GO:0048248 CXCR3 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K4B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R430-1", "uniprot_id": "Q8R430_RAT", "mass": 52325.0, "length": 478, "protein_name": "Oxidative stress-induced growth inhibitor 1", "gene_name": "Osgin1", "organism": "Rat", "refseq_name": "oxidative stress-induced growth inhibitor 1", "refseq_ac": "NP_612513", "gene_names_uniprotkb": "Osgin1", "gene_names_refseq": "Okl38; Osgin1", "protein_names_uniprotkb": "Oxidative stress-induced growth inhibitor 1", "protein_names_refseq": "oxidative stress-induced growth inhibitor 1; pregnancy-induced growth inhibitor", "tax_id": 10116, "disease": "", "pathway": " (rno:171493)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15217983", "class_list": "", "function": "Monooxygenase catalytic activity. Involved in regulation of cytokinesis; promotes RHOA activity, probably acting locally at the midbody in late cytokinesis. Monooxygenase activity is involved in stabilizing transient structures between daughter cells, termed intercellular bridges, before abscission. Regulates differentiation and proliferation through the regulation of cell death., [UniProtKB, UniProtKB]; OKL38 may function as effector for human chorionic gonadotropin protection against mammary carcinogenesis. Availability of three rat OKL38 cDNAs may help to elucidate possible role of OKL38 in cellular growth, differentiation, and carcinogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0030496 midbody", "go_biological_process": "GO:0030154 cell differentiation;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R430-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R5L9-1", "uniprot_id": "Q8R5L9_RAT", "mass": 27150.0, "length": 245, "protein_name": "Fibroblast growth factor", "gene_name": "Fgf3", "organism": "Rat", "refseq_name": "fibroblast growth factor 3 precursor", "refseq_ac": "NP_570830", "gene_names_uniprotkb": "Fgf3", "gene_names_refseq": "Fgf3; Fgf5c; Int2", "protein_names_uniprotkb": "Fibroblast growth factor; FGF", "protein_names_refseq": "fibroblast growth factor 3 precursor; fibroblast growth factor 5c; interacting gene 2", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425)", "pathway": " (rno:170633); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190370); (R-RNO-190377); (R-RNO-5654219); (R-RNO-5654221); (R-RNO-5654687); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5658623); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 19, "publication_count": 1, "publication_id_list": "12960068", "class_list": "", "function": "During fracture repair, strongly expressed in prehypertrophic chondrocytes, and expression level reached maximum on day 14. FGFR3-mediated STAT1-p21 signaling may have role in fracture repair., [RefSeq, PubMed]; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6HYH2;F1LSR1", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001759 organ induction;GO:0048752 semicircular canal morphogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0048538 thymus development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R5L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N74-1", "uniprot_id": "Q99N74_RAT", "mass": 16055.0, "length": 144, "protein_name": "Prolactin-induced protein", "gene_name": "Sval2", "organism": "Rat", "refseq_name": "seminal vesicle antigen-like 2 precursor", "refseq_ac": "NP_579825", "gene_names_uniprotkb": "Sval2", "gene_names_refseq": "SLP-M; Sval2", "protein_names_uniprotkb": "Prolactin-induced protein", "protein_names_refseq": "seminal vesicle antigen-like 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:84605)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6IF59", "ec_number_list": "", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0002682 regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99N74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERL1-1", "uniprot_id": "Q9ERL1_RAT", "mass": 65372.0, "length": 570, "protein_name": "NADPH oxidase 2", "gene_name": "Cybb", "organism": "Rat", "refseq_name": "cytochrome b-245 beta chain", "refseq_ac": "NP_076455", "gene_names_uniprotkb": "Cybb", "gene_names_refseq": "Cybb; Gp91-phox; Nox2", "protein_names_uniprotkb": "NADPH oxidase 2; CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b-245 heavy chain; Heme-binding membrane glycoprotein gp91phox; Neutrophil cytochrome b 91 kDa polypeptide; gp91-1; gp91-phox; p22 phagocyte B-cytochrome", "protein_names_refseq": "NADPH oxidase 2; cytochrome b-245 beta chain; cytochrome b-245, beta polypeptide; endothelial type gp91-phox", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); X-linked chronic granulomatous disease (Disease Ontology:DOID:0070195); immunodeficiency 34 (Disease Ontology:DOID:0112000); hypertension (Disease Ontology:DOID:10763); chronic granulomatous disease (Disease Ontology:DOID:3265); primary hyperaldosteronism (Disease Ontology:DOID:446); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:66021); (R-RNO-1222556); (R-RNO-1236973); (R-RNO-3299685); (R-RNO-4420097); (R-RNO-5668599); (R-RNO-6798695); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013423)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "33806917;34705355;36613540;38240225;39301728", "class_list": "", "function": "Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. NADPH oxidase complex assembly is impaired through interaction with NRROS., [UniProtKB, UniProtKB]; Gestational Hypoxia Impaired Endothelial Nitric Oxide Synthesis Via miR-155-5p/NADPH Oxidase/Reactive Oxygen Species Axis in Male Offspring Vessels., [RefSeq, PubMed]; High-Fat and Combined High-Fat and Sucrose Diets Promote Cardiac Oxidative Stress Independent of Nox2 Redox Regulation and Obesity in Rats., [RefSeq, PubMed]; Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats., [RefSeq, PubMed]; Nox2 Inhibition Regulates Stress Response and Mitigates Skeletal Muscle Fiber Atrophy during Simulated Microgravity. Publication Status: Online-Only, [RefSeq, PubMed]; TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LNC0", "ec_number_list": "1.6.3.-;1.6.3.1", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006952 defense response;GO:0006954 inflammatory response;GO:0007584 response to nutrient;GO:0045087 innate immune response;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ERL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ET45-1", "uniprot_id": "Q9ET45_RAT", "mass": 20978.0, "length": 187, "protein_name": "BCL2 interacting protein 3", "gene_name": "Bnip3", "organism": "Rat", "refseq_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3", "refseq_ac": "NP_445872", "gene_names_uniprotkb": "Bnip3", "gene_names_refseq": "Bnip3", "protein_names_uniprotkb": "BCL2 interacting protein 3", "protein_names_refseq": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19 kDa-interacting protein 3; BCL2/adenovirus E1B interacting protein 3", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); transient cerebral ischemia (Disease Ontology:DOID:224); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:84480)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22673903;31707369;31993850;35951252;36627546;37542244", "class_list": "", "function": "Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy., [RefSeq, PubMed]; Dysregulation of Autophagy, Mitophagy, and Apoptosis Genes in the CA3 Region of the Hippocampus in the Ischemic Model of Alzheimer's Disease in the Rat., [RefSeq, PubMed]; Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy., [RefSeq, PubMed]; Roles of HIF-1alpha/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats., [RefSeq, PubMed]; The worsening of skeletal muscle atrophy induced by immobilization at the early stage of remobilization correlates with BNIP3-dependent mitophagy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6HX99", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051020 GTPase binding;GO:0140506 endoplasmic reticulum-autophagosome adaptor activity;GO:0140580 mitochondrion autophagosome adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0050873 brown fat cell differentiation;GO:0051402 neuron apoptotic process;GO:0051607 defense response to virus;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ET45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVJ6-1", "uniprot_id": "TGM2_RAT", "mass": 76935.0, "length": 686, "protein_name": "Protein-glutamine gamma-glutamyltransferase 2", "gene_name": "Kiaa1755; Tgm2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Kiaa1755; Tgm2; Kiaa1755; RGD1563354", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase 2; 2.3.1.-; 2.3.2.13; 3.4.-.-; 3.5.1.44; Isopeptidase TGM2; Protein G alpha(h); Protein G(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; TGase 2; TGase II; TGase-2; Tissue transglutaminase; Transglutaminase II; Transglutaminase-2; tTG; tTgase", "protein_names_refseq": "", "tax_id": 10116, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524)", "pathway": " (rno:311592); (rno:56083)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11073883;12054611;14970202;16341586;17179049;29622788;34502162;7911253", "class_list": "", "function": "Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (By similarity). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (By similarity). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:16341586, PubMed:29622788). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (By similarity). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (By similarity). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (By similarity). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (By similarity). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (By similarity). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (By similarity). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (By similarity). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (By similarity). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (By similarity). May also act as an isopeptidase cleaving the previously formed cross-links (By similarity). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:12054611, PubMed:14970202, PubMed:7911253). Activates alpha-1 adrenergic receptor signaling during pregnancy, promoting smooth muscle cell proliferation (PubMed:14970202)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6R6", "ec_number_list": "2.3.2.13;3.4.-.-;2.3.1.-;3.5.1.44", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:1903672 positive regulation of sprouting angiogenesis;GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine;GO:0006508 proteolysis;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WVJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZRW8-1", "uniprot_id": "EKI2_RAT", "mass": 44734.0, "length": 385, "protein_name": "Ethanolamine kinase 2", "gene_name": "Etnk2", "organism": "Rat", "refseq_name": "ethanolamine kinase 2", "refseq_ac": "NP_001406523", "gene_names_uniprotkb": "Etnk2", "gene_names_refseq": "EKI 2; Etnk2", "protein_names_uniprotkb": "Ethanolamine kinase 2; 2.7.1.82; EKI 2; Ethanolamine kinase-like protein", "protein_names_refseq": "ethanolamine kinase 2; ethanolamine kinase-like protein", "tax_id": 10116, "disease": "heart conduction disease (Disease Ontology:DOID:10273); microcephaly (Disease Ontology:DOID:10907); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:360843); (R-RNO-1483213)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the ATP-dependent phosphorylation of ethanolamine to phosphoethanolamine (By similarity). Highly specific for ethanolamine phosphorylation and does not exhibit choline kinase activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A6J5", "ec_number_list": "2.7.1.82;2.7.1.32", "go_molecular_function": "GO:0005524 ATP binding;GO:0004305 ethanolamine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0035264 multicellular organism growth;GO:0001890 placenta development;GO:0009791 post-embryonic development;GO:0016310 phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZRW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ADY9-1", "uniprot_id": "ELOV7_RAT", "mass": 33547.0, "length": 281, "protein_name": "Very long chain fatty acid elongase 7", "gene_name": "Elovl7", "organism": "Rat", "refseq_name": "very long chain fatty acid elongase 7", "refseq_ac": "NP_001178773", "gene_names_uniprotkb": "Elovl7", "gene_names_refseq": "Elovl7", "protein_names_uniprotkb": "Very long chain fatty acid elongase 7; 2.3.1.199; 3-keto acyl-CoA synthase Elovl7; ELOVL FA elongase 7; ELOVL fatty acid elongase 7; Elongation of very long chain fatty acids protein 7; Very long chain 3-ketoacyl-CoA synthase 7; Very long chain 3-oxoacyl-CoA synthase 7", "protein_names_refseq": "3-keto acyl-CoA synthase Elovl7; ELOVL FA elongase 7; elongation of very long chain fatty acids protein 7; very long chain 3-ketoacyl-CoA synthase 7; very long chain 3-oxoacyl-CoA synthase 7; very long chain fatty acid elongase 7", "tax_id": 10116, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (rno:361895); (R-RNO-75876)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0034626 fatty acid elongation, polyunsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ADY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LMN3-1", "uniprot_id": "E2F8_RAT", "mass": 93023.0, "length": 860, "protein_name": "Transcription factor E2F8", "gene_name": "E2f8", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "E2f8", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor E2F8; E2F-8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:308607); (R-RNO-6804116)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZV5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:0033301 cell cycle comprising mitosis without cytokinesis;GO:0060718 chorionic trophoblast cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LMN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08680-1", "uniprot_id": "EPHA3_RAT", "mass": 110228.0, "length": 984, "protein_name": "Ephrin type-A receptor 3", "gene_name": "Epha3", "organism": "Rat", "refseq_name": "ephrin type-A receptor 3 precursor", "refseq_ac": "NP_113752", "gene_names_uniprotkb": "Epha3; Rek4; Tyro4", "gene_names_refseq": "Epha3", "protein_names_uniprotkb": "Ephrin type-A receptor 3; 2.7.10.1; EK4; EPH-like kinase 4; Tyrosine-protein kinase TYRO4; rEK4", "protein_names_refseq": "EK4; EPH-like kinase 4; ephrin type-A receptor 3 precursor; ephrin type-A receptor 3; rEK4; tyrosine-protein kinase TYRO4; tyrosine-protein kinase receptor REK4", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (rno:29210); (R-RNO-2682334); (R-RNO-3928663); (R-RNO-3928665)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "27721017;9458884", "class_list": "", "function": "EphA3 promotes malignant transformation of colorectal epithelial cells by upregulating oncogenic signaling pathways., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Also activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.10.2;2.7.12.2;2.7.1.40;2.7.11.1;2.7.11.13;2.7.10.4;3.6.5.2;2.7.1.32;2.7.1.82;2.7.11.23", "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0098793 presynapse", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0051893 regulation of focal adhesion assembly;GO:0001660 fever generation;GO:0045806 negative regulation of endocytosis;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08680-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1WC10-1", "uniprot_id": "FRITZ_RAT", "mass": 81910.0, "length": 726, "protein_name": "WD repeat-containing and planar cell polarity effector protein fritz homolog", "gene_name": "Wdpcp", "organism": "Rat", "refseq_name": "WD repeat-containing and planar cell polarity effector protein fritz homolog", "refseq_ac": "NP_001121009", "gene_names_uniprotkb": "Wdpcp", "gene_names_refseq": "RGD1309501; Wdpcp", "protein_names_uniprotkb": "WD repeat-containing and planar cell polarity effector protein fritz homolog; WD repeat-containing and planar cell polarity effector protein", "protein_names_refseq": "WD repeat-containing and planar cell polarity effector protein fritz homolog", "tax_id": 10116, "disease": "Bardet-Biedl syndrome 15 (Disease Ontology:DOID:0110137); congenital heart defects, hamartomas of tongue, and polysyndactyly (Disease Ontology:DOID:0111591); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:305552)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005930 axoneme;GO:0097541 axonemal basal plate", "go_biological_process": "GO:1900027 regulation of ruffle assembly;GO:0010762 regulation of fibroblast migration;GO:0072359 circulatory system development;GO:0051893 regulation of focal adhesion assembly;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WC10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70436-1", "uniprot_id": "SMAD2_RAT", "mass": 52239.0, "length": 467, "protein_name": "SMAD family member 2", "gene_name": "Smad2; Smad3", "organism": "Rat", "refseq_name": "SMAD family member 2", "refseq_ac": "NP_001264379", "gene_names_uniprotkb": "Smad2; Smad3; Madh2; Smad2", "gene_names_refseq": "Madh2; Smad2", "protein_names_uniprotkb": "SMAD family member 2; MAD homolog 2; Mad-related protein 2; Mothers against DPP homolog 2; Mothers against decapentaplegic homolog 2; SMAD 2", "protein_names_refseq": "SMAD 2; SMAD family member 2; mad-related protein 2; mothers against DPP homolog 2; mothers against decapentaplegic homolog 2", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Loeys-Dietz syndrome 6 (Disease Ontology:DOID:0060964); endometrial cancer (Disease Ontology:DOID:1380); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); Lynch syndrome (Disease Ontology:DOID:3883); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:29357); (R-RNO-1181150); (R-RNO-1502540); (R-RNO-2173788); (R-RNO-2173789); (R-RNO-2173795); (R-RNO-2173796); (R-RNO-5689880); (R-RNO-9617828)", "pathway_count": 9, "publication_count": 10, "publication_id_list": "10382592;10670756;21791611;23610057;29783655;36631456;36857632;37676431;39105875;39168432", "class_list": "", "function": "Candida albicans-induced activation of the TGF-beta/Smad pathway and upregulation of IL-6 may contribute to intrauterine adhesion. Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA-499-5p inhibits transforming growth factor-beta1-induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFbeta-R1. Erratum:[Mol Biol Rep. 2024 Apr 20;51(1):552. doi: 10.1007/s11033-024-09226-w. PMID: 38642166], [RefSeq, PubMed]; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin II-induced atrial fibrosis and vulnerability to atrial fibrillation via suppression of the TGF-beta1/smad2/3 signalling pathway., [RefSeq, PubMed]; TGF-beta1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in rat Leydig cellsdagger., [RefSeq, PubMed]; Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-beta and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JPM1", "ec_number_list": "", "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0071559 response to transforming growth factor beta;GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0048340 paraxial mesoderm morphogenesis;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O70436-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02650-1", "uniprot_id": "APOE_RAT", "mass": 35753.0, "length": 312, "protein_name": "Apolipoprotein E", "gene_name": "Apoe", "organism": "Rat", "refseq_name": "apolipoprotein E precursor", "refseq_ac": "NP_001257610", "gene_names_uniprotkb": "Apoe", "gene_names_refseq": "APOEA; Apoe", "protein_names_uniprotkb": "Apolipoprotein E; Apo-E", "protein_names_refseq": "apo-E; apolipoprotein E precursor", "tax_id": 10116, "disease": "primary cutaneous amyloidosis (Disease Ontology:DOID:0050639); glomerulosclerosis (Disease Ontology:DOID:0050851); left ventricular failure (Disease Ontology:DOID:0051064); herpes simplex virus keratitis (Disease Ontology:DOID:0080158); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); age related macular degeneration 1 (Disease Ontology:DOID:0110014); Alzheimer's disease 2 (Disease Ontology:DOID:0110035); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); sensorineural hearing loss (Disease Ontology:DOID:10003); cholelithiasis (Disease Ontology:DOID:10211); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); membranous glomerulonephritis (Disease Ontology:DOID:10976); sciatic neuropathy (Disease Ontology:DOID:11446); familial hyperlipidemia (Disease Ontology:DOID:1168); nephrotic syndrome (Disease Ontology:DOID:1184); Lewy body dementia (Disease Ontology:DOID:12217); beta thalassemia (Disease Ontology:DOID:12241); malaria (Disease Ontology:DOID:12365); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); low tension glaucoma (Disease Ontology:DOID:13544); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); exfoliation syndrome (Disease Ontology:DOID:13641); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial hypercholesterolemia (Disease Ontology:DOID:13810); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); hyperuricemia (Disease Ontology:DOID:1920); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); gallbladder cancer (Disease Ontology:DOID:3121); hyperlipoproteinemia type III (Disease Ontology:DOID:3145); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); lung carcinoma (Disease Ontology:DOID:3905); sea-blue histiocytosis (Disease Ontology:DOID:4423); macular degeneration (Disease Ontology:DOID:4448); bile duct cancer (Disease Ontology:DOID:4606); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); cerebrovascular disease (Disease Ontology:DOID:6713); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); herpes simplex (Disease Ontology:DOID:8566); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); hyperhomocysteinemia (Disease Ontology:DOID:9279); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25728); (R-RNO-3000480); (R-RNO-381426); (R-RNO-8957275); (R-RNO-8963888); (R-RNO-8963901); (R-RNO-8964026); (R-RNO-8964058); (R-RNO-975634)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "21454685;22673903;3020048;36104381;37081644;37658943;3797247;38393618;38772427;6190813;7766086", "class_list": "", "function": "APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE also has a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells., [UniProtKB, UniProtKB]; Apolipoprotein E-depletion accelerates arterial fat deposition in the spontaneously hypertensive rat., [RefSeq, PubMed]; Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-kappaB Signaling Pathway., [RefSeq, PubMed]; Exploring the parity paradox: Differential effects on neuroplasticity and inflammation by APOEe4 genotype at middle age., [RefSeq, PubMed]; Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats. Publication Status: Online-Only, [RefSeq, PubMed]; The role of ApoE in fatty acid transport from neurons to astrocytes under ischemia/hypoxia conditions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 65, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005319 lipid transporter activity;GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005768 endosome", "go_biological_process": "GO:0072359 circulatory system development;GO:0050709 negative regulation of protein secretion;GO:0097006 regulation of plasma lipoprotein particle levels;GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P02650-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35346-1", "uniprot_id": "FAK1_RAT", "mass": 119717.0, "length": 1055, "protein_name": "Focal adhesion kinase 1", "gene_name": "Ptk2", "organism": "Rat", "refseq_name": "focal adhesion kinase 1", "refseq_ac": "NP_037213", "gene_names_uniprotkb": "Ptk2; Fak1; Fak", "gene_names_refseq": "FAK; FRNK; Ptk2; p125FAK", "protein_names_uniprotkb": "Focal adhesion kinase 1; 2.7.10.2; FADK 1; FRNK; Focal adhesion kinase-related nonkinase; Protein-tyrosine kinase 2; p125FAK; pp125FAK", "protein_names_refseq": "FADK 1; PTK2 protein tyrosine kinase 2; focal adhesion kinase 1; focal adhesion kinase-related nonkinase; pp125FAK", "tax_id": 10116, "disease": "extrapulmonary tuberculosis (Disease Ontology:DOID:0050598); ductal carcinoma in situ (Disease Ontology:DOID:0060074); endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); leiomyoma (Disease Ontology:DOID:127); endometrial carcinoma (Disease Ontology:DOID:2871); endometriosis (Disease Ontology:DOID:289); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); ischemia (Disease Ontology:DOID:326); lung squamous cell carcinoma (Disease Ontology:DOID:3907); tuberculosis (Disease Ontology:DOID:399); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); uremia (Disease Ontology:DOID:4676); lung small cell carcinoma (Disease Ontology:DOID:5409); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); cholesteatoma (Disease Ontology:DOID:869)", "pathway": " (rno:25614); (R-RNO-111465); (R-RNO-2029482); (R-RNO-354192); (R-RNO-354194); (R-RNO-372708); (R-RNO-375165); (R-RNO-3928662); (R-RNO-418885); (R-RNO-4420097); (R-RNO-5663213); (R-RNO-5673001); (R-RNO-8874081); (R-RNO-9009391); (R-RNO-9860927)", "pathway_count": 15, "publication_count": 66, "publication_id_list": "11882598;12702722;12732587;12805241;14500712;15096502;15451029;15494733;15537746;15817454;15923313;15930288;16195476;16373587;16547166;16618703;16825486;17003277;17240116;17549512;17976369;18539755;19361463;19364917;19470782;19880666;21246051;21357465;21378178;22006118;22276220;22654119;22673903;22797892;22900166;22914642;23118988;24169556;24217647;24772088;24884636;25300309;26018803;27994061;28744198;29018403;30187999;30355914;30510582;30853931;31784544;32352989;32592615;32707896;33051346;33434537;33692398;33847460;33920786;34194565;37607602;8738136;9334354;9353341;9374543;9422762", "class_list": "", "function": "Does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibited effect of an RGD peptide hydrogel on the expression of beta1-integrin, FAK, and Akt in Tenon's capsule fibroblasts., [RefSeq, PubMed]; Low-activity programming of the PDGFRbeta/FAK pathway mediates H-type vessel dysplasia and high susceptibility to osteoporosis in female offspring rats after prenatal dexamethasone exposure., [RefSeq, PubMed]; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G protein-coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (By similarity). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Quantitative Phase Imaging of Spreading Fibroblasts Identifies the Role of Focal Adhesion Kinase in the Stabilization of the Cell Rear. Publication Status: Online-Only, [RefSeq, PubMed]; Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons., [RefSeq, PubMed]; Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62900", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.11.1;2.7.1.153;2.7.1.137;2.7.10.2;2.7.12.2;2.7.1.40;2.7.11.10;2.7.11.17;3.6.5.2;2.7.11.13;2.7.10.4;3.6.5.-;3.6.4.10;2.7.1.32;2.7.1.82;3.1.3.48;2.7.11.39;2.7.11.23;3.2.1.31", "go_molecular_function": "GO:0003779 actin binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005178 integrin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1900024 regulation of substrate adhesion-dependent cell spreading;GO:0046621 negative regulation of organ growth;GO:0046685 response to arsenic-containing substance;GO:0051893 regulation of focal adhesion assembly;GO:0060252 positive regulation of glial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 6.7, "record_id": "O35346-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1L1K3-1", "uniprot_id": "APC5_RAT", "mass": 81739.0, "length": 727, "protein_name": "Anaphase-promoting complex subunit 5", "gene_name": "Anapc5", "organism": "Rat", "refseq_name": "anaphase-promoting complex subunit 5 isoform 1", "refseq_ac": "NP_001073616", "gene_names_uniprotkb": "Anapc5", "gene_names_refseq": "APC5; Anapc5", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5", "protein_names_refseq": "anaphase-promoting complex subunit 5 isoform 1; cyclosome subunit 5", "tax_id": 10116, "disease": "", "pathway": " (rno:288671); (R-RNO-141430); (R-RNO-174048); (R-RNO-174084); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-176407); (R-RNO-176408); (R-RNO-176412); (R-RNO-179409); (R-RNO-2467813); (R-RNO-2559582); (R-RNO-68867); (R-RNO-69017); (R-RNO-983168)", "pathway_count": 16, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0045842 positive regulation of mitotic metaphase/anaphase transition;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L1K3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88969-1", "uniprot_id": "CST8_RAT", "mass": 16246.0, "length": 142, "protein_name": "Cystatin-8", "gene_name": "Cst8", "organism": "Rat", "refseq_name": "cystatin-8 precursor", "refseq_ac": "NP_062131", "gene_names_uniprotkb": "Cst8; Cres", "gene_names_refseq": "Cst8", "protein_names_uniprotkb": "Cystatin-8; Cystatin-related epididymal spermatogenic protein", "protein_names_refseq": "cystatin 8 (cystatin-related epididymal specific); cystatin 8 (cystatin-related epididymal spermatogenic); cystatin-8 precursor; cystatin-related epididymal spermatogenic protein", "tax_id": 10116, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); COVID-19 (Disease Ontology:DOID:0080600); Parkinsonism (Disease Ontology:DOID:0080855); silicosis (Disease Ontology:DOID:10325); pneumocystosis (Disease Ontology:DOID:11339); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); neutropenia (Disease Ontology:DOID:1227); temporal arteritis (Disease Ontology:DOID:13375); interstitial cystitis (Disease Ontology:DOID:13949); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); myocardial infarction (Disease Ontology:DOID:5844); abdominal aortic aneurysm (Disease Ontology:DOID:7693); acute myeloid leukemia (Disease Ontology:DOID:9119); visceral leishmaniasis (Disease Ontology:DOID:9146)", "pathway": " (rno:29679)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10229662", "class_list": "", "function": "Performs a specialized role during sperm development and maturation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0009986 cell surface", "go_biological_process": "GO:0048678 response to axon injury;GO:0007431 salivary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88969-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0K012-1", "uniprot_id": "CMKMT_RAT", "mass": 35883.0, "length": 323, "protein_name": "Calmodulin-lysine N-methyltransferase", "gene_name": "Camkmt", "organism": "Rat", "refseq_name": "calmodulin-lysine N-methyltransferase", "refseq_ac": "NP_001127935", "gene_names_uniprotkb": "Camkmt; Clnmt", "gene_names_refseq": "CLNMT; CaM KMT; Camkmt; RGD1310453", "protein_names_uniprotkb": "Calmodulin-lysine N-methyltransferase; 2.1.1.60; CLNMT; CaM KMT", "protein_names_refseq": "calmodulin-lysine N-methyltransferase", "tax_id": 10116, "disease": "hypotonia-cystinuria syndrome (Disease Ontology:DOID:0060858)", "pathway": " (rno:299521); (R-RNO-2514859); (R-RNO-8876725)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "20975703;3700427", "class_list": "", "function": "Catalyzes the trimethylation of 'Lys-116' in calmodulin., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.60", "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0018025 calmodulin-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex;GO:0005634 nucleus", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0018022 peptidyl-lysine methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0K012-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZTE0-1", "uniprot_id": "FA12_RAT", "mass": 65844.0, "length": 595, "protein_name": "Coagulation factor XII", "gene_name": "F12", "organism": "Rat", "refseq_name": "coagulation factor XII precursor", "refseq_ac": "NP_001014028", "gene_names_uniprotkb": "F12", "gene_names_refseq": "F12; HAF", "protein_names_uniprotkb": "Coagulation factor XII; 3.4.21.38; HAF; Hageman factor", "protein_names_refseq": "coagulation factor XII precursor; factor XII; hageman factor", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); hereditary angioedema type III (Disease Ontology:DOID:0080940); acquired angioedema (Disease Ontology:DOID:0080941); hereditary angioedema (Disease Ontology:DOID:14735); angioedema (Disease Ontology:DOID:1558); factor XII deficiency (Disease Ontology:DOID:2231); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:306761); (R-RNO-9855719); (R-RNO-9935598); (R-RNO-9970672)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22216926;24733030;29393594", "class_list": "", "function": "Beta-FXIIa infusion induces both adrenal catecholamine-mediated and adrenally independent increases in peripheral resistance, [RefSeq, PubMed]; FXIIa-kininogen mediated vasoconstriction contributes significantly to CKD hypertension in Brown Norway rats., [RefSeq, PubMed]; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 2, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5M879", "ec_number_list": "3.4.21.38;3.4.21.34", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005791 rough endoplasmic reticulum", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0007596 blood coagulation;GO:0042730 fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZTE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88626-1", "uniprot_id": "GALR3_RAT", "mass": 40410.0, "length": 370, "protein_name": "Galanin receptor type 3", "gene_name": "Galr3", "organism": "Rat", "refseq_name": "galanin receptor type 3", "refseq_ac": "NP_062046", "gene_names_uniprotkb": "Galr3; Galnr3", "gene_names_refseq": "Galr3", "protein_names_uniprotkb": "Galanin receptor type 3; GAL3-R; GALR-3", "protein_names_refseq": "GAL3-R; GALR-3; galanin receptor type 3", "tax_id": 10116, "disease": "", "pathway": " (rno:29235); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10619483;15944004;20974494;9722565", "class_list": "", "function": "Data show that a galanin or a galanin receptor R2/3 agonist doubles the size of the ischemic lesion following middle cerebral artery occlusion in rats., [RefSeq, PubMed]; Receptor for the hormone galanin and spexin-1., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The efficacy of galanin to induce an effective coupling of its receptors to G proteins could be different depending on the brain area, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54914;Q9QWZ2", "ec_number_list": "", "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004966 galanin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0097730 non-motile cilium;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0090663 galanin-activated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88626-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0JPQ8-1", "uniprot_id": "ALKMO_RAT", "mass": 51698.0, "length": 447, "protein_name": "Alkylglycerol monooxygenase", "gene_name": "Agmo", "organism": "Rat", "refseq_name": "alkylglycerol monooxygenase", "refseq_ac": "NP_001129371", "gene_names_uniprotkb": "Agmo; Tmem195", "gene_names_refseq": "Agmo; RGD1312038; Tmem195", "protein_names_uniprotkb": "Alkylglycerol monooxygenase; 1.14.16.5; Transmembrane protein 195", "protein_names_refseq": "alkylglycerol monooxygenase; transmembrane protein 195", "tax_id": 10116, "disease": "", "pathway": " (rno:362732); (R-RNO-75109)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.16.5", "go_molecular_function": "GO:0005506 iron ion binding;GO:0050479 glyceryl-ether monooxygenase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006643 membrane lipid metabolic process;GO:0019432 triglyceride biosynthetic process;GO:0046485 ether lipid metabolic process;GO:0008610 lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JPQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1KXW8-1", "uniprot_id": "FA72A_RAT", "mass": 16756.0, "length": 149, "protein_name": "Protein FAM72A", "gene_name": "Fam72a", "organism": "Rat", "refseq_name": "protein FAM72A", "refseq_ac": "NP_001074920", "gene_names_uniprotkb": "Fam72a", "gene_names_refseq": "Fam72a", "protein_names_uniprotkb": "Protein FAM72A; Dpr4-related protein", "protein_names_refseq": "dpr4-related protein; protein FAM72A", "tax_id": 10116, "disease": "", "pathway": " (rno:681249)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1KXW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1L1K7-1", "uniprot_id": "ACBG2_RAT", "mass": 74266.0, "length": 667, "protein_name": "Long-chain-fatty-acid--CoA ligase ACSBG2", "gene_name": "Acsbg2", "organism": "Rat", "refseq_name": "long-chain-fatty-acid--CoA ligase ACSBG2", "refseq_ac": "NP_001073565", "gene_names_uniprotkb": "Acsbg2", "gene_names_refseq": "Acsbg2", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase ACSBG2; 6.2.1.15; 6.2.1.3; Acyl-CoA synthetase bubblegum family member 2; Arachidonate--CoA ligase ACSBG2", "protein_names_refseq": "arachidonate--CoA ligase ACSBG2; bubblegum-related acyl-CoA synthetase 2; long-chain-fatty-acid--CoA ligase ACSBG2", "tax_id": 10116, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (rno:301120); (R-RNO-75876)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;6.2.1.15;6.2.1.76;6.2.1.7;6.2.1.24;6.2.1.-;6.2.1.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L1K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2RRT9-1", "uniprot_id": "CP4V2_RAT", "mass": 60580.0, "length": 525, "protein_name": "Cytochrome P450 4V2", "gene_name": "Cyp4v2", "organism": "Rat", "refseq_name": "cytochrome P450 4V2", "refseq_ac": "NP_001129072", "gene_names_uniprotkb": "Cyp4v2; Cyp4v3", "gene_names_refseq": "Cyp4v2; Cyp4v3", "protein_names_uniprotkb": "Cytochrome P450 4V2; 1.14.14.79; 1.14.14.80; Docosahexaenoic acid omega-hydroxylase CYP4V2; Long-chain fatty acid omega-monooxygenase", "protein_names_refseq": "cytochrome P450 4V2; cytochrome P450 4V3; cytochrome P450-like protein; docosahexaenoic acid omega-hydroxylase CYP4V2; long-chain fatty acid omega-monooxygenase", "tax_id": 10116, "disease": "Bietti crystalline corneoretinal dystrophy (Disease Ontology:DOID:0050664)", "pathway": " (rno:266761); (R-RNO-211976); (R-RNO-2453902)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12025956;29393594", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB]; Tissue kallikrein mRNA expression is increased during prenatal and early postnatal development stages in rat brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.80;1.14.14.79;1.14.14.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0102033 long-chain fatty acid omega-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010430 fatty acid omega-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2RRT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A4KWA5-1", "uniprot_id": "CL2D2_RAT", "mass": 25559.0, "length": 233, "protein_name": "C-type lectin domain family 2 member D2", "gene_name": "Clec2d2", "organism": "Rat", "refseq_name": "C-type lectin domain family 2 member D2", "refseq_ac": "NP_001078871", "gene_names_uniprotkb": "Clec2d2", "gene_names_refseq": "Clec2d2; Clr2; RGD1562831", "protein_names_uniprotkb": "C-type lectin domain family 2 member D2", "protein_names_refseq": "C-type lectin domain family 2 member D2; C-type lectin-related protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:362445)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17462921", "class_list": "", "function": "Lectin-type cell surface receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4KWA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A4KWA8-1", "uniprot_id": "CL2D6_RAT", "mass": 25877.0, "length": 233, "protein_name": "C-type lectin domain family 2 member D6", "gene_name": "Clec2d6; Clec2dl1", "organism": "Rat", "refseq_name": "C-type lectin domain family 2 member D6", "refseq_ac": "NP_001078873", "gene_names_uniprotkb": "Clec2d6; Clec2dl1", "gene_names_refseq": "Clec2d6; Clec2dl1", "protein_names_uniprotkb": "C-type lectin domain family 2 member D6", "protein_names_refseq": "C-type lectin domain family 2 member D6", "tax_id": 10116, "disease": "", "pathway": " (rno:689790)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17462921", "class_list": "", "function": "Lectin-type cell surface receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4KWA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6JFQ6-1", "uniprot_id": "CLVS1_RAT", "mass": 40667.0, "length": 354, "protein_name": "Clavesin-1", "gene_name": "Clvs1", "organism": "Rat", "refseq_name": "clavesin-1", "refseq_ac": "NP_001102439", "gene_names_uniprotkb": "Clvs1; Rlbp1l1", "gene_names_refseq": "Clavesin-1; Clvs1; RGD1564200; Rlbp1l1", "protein_names_uniprotkb": "Clavesin-1; Retinaldehyde-binding protein 1-like 1", "protein_names_refseq": "Retinaldehyde-binding protein 1-like protein 1; clavesin-1; retinaldehyde-binding protein 1-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:366311); (R-RNO-432720)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19651769", "class_list": "", "function": "Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005768 endosome;GO:0031901 early endosome membrane;GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6JFQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BMW8-1", "uniprot_id": "FACE2_RAT", "mass": 33646.0, "length": 308, "protein_name": "CAAX prenyl protease 2", "gene_name": "Rce1", "organism": "Rat", "refseq_name": "CAAX prenyl protease 2", "refseq_ac": "NP_001094055", "gene_names_uniprotkb": "Rce1", "gene_names_refseq": "Rce1", "protein_names_uniprotkb": "CAAX prenyl protease 2; 3.4.26.1; FACE-2; Farnesylated proteins-converting enzyme 2; Prenyl protein-specific endoprotease 2; RCE1 homolog", "protein_names_refseq": "CAAX prenyl protease 2; FACE-2; RCE1 homolog, prenyl protein peptidase; RCE1 homolog, prenyl protein protease; farnesylated proteins-converting enzyme 2; prenyl protein-specific endoprotease 2", "tax_id": 10116, "disease": "", "pathway": " (rno:309153); (R-RNO-5689880); (R-RNO-9648002)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus. Is able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12;3.6.4.13;3.4.26.1;3.6.5.2;3.1.3.48", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008238 exopeptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071586 CAAX-box protein processing;GO:0018342 protein prenylation;GO:0080120 CAAX-box protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BMW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BND4-1", "uniprot_id": "F229B_RAT", "mass": 8797.0, "length": 80, "protein_name": "Protein FAM229B", "gene_name": "Fam229b", "organism": "Rat", "refseq_name": "protein FAM229B", "refseq_ac": "NP_001128167", "gene_names_uniprotkb": "Fam229b", "gene_names_refseq": "Fam229b", "protein_names_uniprotkb": "Protein FAM229B", "protein_names_refseq": "UPF0731 protein C6orf225 homolog; protein FAM229B", "tax_id": 10116, "disease": "", "pathway": " (rno:100188933)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BND4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BNE4-1", "uniprot_id": "EPAB2_RAT", "mass": 29861.0, "length": 269, "protein_name": "Embryonic polyadenylate-binding protein 2", "gene_name": "Pabpn1l", "organism": "Rat", "refseq_name": "embryonic polyadenylate-binding protein 2", "refseq_ac": "NP_001107251", "gene_names_uniprotkb": "Pabpn1l; Epabp2; Pabpnl1", "gene_names_refseq": "Epabp2; Pabpn1l; Pabpnl1; RGD1562761", "protein_names_uniprotkb": "Embryonic polyadenylate-binding protein 2; Embryonic poly(A)-binding protein 2; Embryonic poly(A)-binding protein type II; Poly(A)-binding protein nuclear-like 1; ePABP-2; ePABP2", "protein_names_refseq": "Embryonic poly(A)-binding protein 2; Embryonic poly(A)-binding protein type II; ePABP-2; embryonic polyadenylate-binding protein 2; poly(A)binding protein nuclear 1-like; poly(A)binding protein nuclear-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:307920)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds the poly(A) tail of mRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0031397 negative regulation of protein ubiquitination;GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0062026 negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process;GO:0160021 maternal-to-zygotic transition of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BNE5-1", "uniprot_id": "ESTD_RAT", "mass": 31364.0, "length": 282, "protein_name": "S-formylglutathione hydrolase", "gene_name": "Esd", "organism": "Rat", "refseq_name": "S-formylglutathione hydrolase isoform a", "refseq_ac": "NP_001099521", "gene_names_uniprotkb": "Esd", "gene_names_refseq": "Esd", "protein_names_uniprotkb": "S-formylglutathione hydrolase; 3.1.2.12; Esterase D; FGH", "protein_names_refseq": "FGH; S-formylglutathione hydrolase isoform a; S-formylglutathione hydrolase; esterase D/formylglutathione hydrolase", "tax_id": 10116, "disease": "", "pathway": " (rno:290401); (R-RNO-156590)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine hydrolase involved in the detoxification of formaldehyde., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.12", "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0042802 identical protein binding;GO:0052689 carboxylic ester hydrolase activity;GO:0018738 S-formylglutathione hydrolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0046294 formaldehyde catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BNK9-1", "uniprot_id": "EFC4A_RAT", "mass": 44553.0, "length": 393, "protein_name": "EF-hand calcium-binding domain-containing protein 4A", "gene_name": "Cracr2b", "organism": "Rat", "refseq_name": "EF-hand calcium-binding domain-containing protein 4A isoform 1", "refseq_ac": "NP_001121013", "gene_names_uniprotkb": "Cracr2b; Efcab4a", "gene_names_refseq": "Cracr2b; Efcab4a; RGD1560911", "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 4A; Calcium release-activated channel regulator 2B", "protein_names_refseq": "EF-hand calcium binding domain 4A; EF-hand calcium-binding domain-containing protein 4A isoform 1; EF-hand calcium-binding domain-containing protein 4A-like; EF-hand calcium-binding domain-containing protein 4A", "tax_id": 10116, "disease": "", "pathway": " (rno:309112)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in store-operated Ca(2+) entry (SOCE)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1WBS9-1", "uniprot_id": "FA24A_RAT", "mass": 10674.0, "length": 98, "protein_name": "Protein FAM24A", "gene_name": "Fam24a", "organism": "Rat", "refseq_name": "protein FAM24A precursor", "refseq_ac": "NP_001102628", "gene_names_uniprotkb": "Fam24a", "gene_names_refseq": "Fam24a; RGD1560948", "protein_names_uniprotkb": "Protein FAM24A", "protein_names_refseq": "protein FAM24A precursor; protein FAM24A", "tax_id": 10116, "disease": "", "pathway": " (rno:499278)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WBS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1WC88-1", "uniprot_id": "CR032_RAT", "mass": 8169.0, "length": 72, "protein_name": "UPF0729 protein C18orf32 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "UPF0729 protein C18orf32 homolog", "refseq_ac": "NP_001166943", "gene_names_uniprotkb": "", "gene_names_refseq": "C18h18orf32; RGD1562987", "protein_names_uniprotkb": "UPF0729 protein C18orf32 homolog", "protein_names_refseq": "UPF0729 protein C18orf32 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:498886)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May activate the NF-kappa-B signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WC88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RYD2-1", "uniprot_id": "ESRP1_RAT", "mass": 75021.0, "length": 677, "protein_name": "Epithelial splicing regulatory protein 1", "gene_name": "Esrp1", "organism": "Rat", "refseq_name": "epithelial splicing regulatory protein 1 isoform 3", "refseq_ac": "NP_001121036", "gene_names_uniprotkb": "Esrp1; Rbm35a", "gene_names_refseq": "Esrp1; RGD1560481", "protein_names_uniprotkb": "Epithelial splicing regulatory protein 1; RNA-binding motif protein 35A; RNA-binding protein 35A", "protein_names_refseq": "RNA-binding motif protein 35A; RNA-binding protein 35A; epithelial splicing regulatory protein 1 isoform 3", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 109 (Disease Ontology:DOID:0111639)", "pathway": " (rno:500409); (R-RNO-6803529)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23825128", "class_list": "", "function": "Data suggest that alternative splicing in ESRP1 transcripts in somatotroph adenoma cells is essential in epithelial-mesenchymal transition progression and in response to somatostatin analog antineoplastic treatment., [RefSeq, PubMed]; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0043484 regulation of RNA splicing;GO:0050679 positive regulation of epithelial cell proliferation;GO:0042669 regulation of inner ear auditory receptor cell fate specification;GO:0060445 branching involved in salivary gland morphogenesis;GO:0060441 epithelial tube branching involved in lung morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RYD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RYG1-1", "uniprot_id": "FA32A_RAT", "mass": 13242.0, "length": 112, "protein_name": "Protein FAM32A", "gene_name": "Fam32a", "organism": "Rat", "refseq_name": "protein FAM32A", "refseq_ac": "NP_001121550", "gene_names_uniprotkb": "Fam32a; Otag12", "gene_names_refseq": "Fam32a; OTAG-12; RGD1561287", "protein_names_uniprotkb": "Protein FAM32A; OTAG-12; Ovarian tumor associated gene 12", "protein_names_refseq": "ovarian tumor associated gene 12; protein FAM32A", "tax_id": 10116, "disease": "", "pathway": " (rno:498600); (R-RNO-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0071007 U2-type catalytic step 2 spliceosome", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RYG8-1", "uniprot_id": "ELP6_RAT", "mass": 29459.0, "length": 266, "protein_name": "Elongator complex protein 6", "gene_name": "Elp6", "organism": "Rat", "refseq_name": "elongator complex protein 6", "refseq_ac": "NP_001102252", "gene_names_uniprotkb": "Elp6", "gene_names_refseq": "Elp6; RGD1305478; Tmem103", "protein_names_uniprotkb": "Elongator complex protein 6; Protein TMEM103", "protein_names_refseq": "UPF0405 protein C3orf75 homolog; elongator complex protein 6 homolog; elongator complex protein 6; transmembrane protein 103", "tax_id": 10116, "disease": "", "pathway": " (rno:363150)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in cell migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0010992 ubiquitin recycling;GO:0048877 homeostasis of number of retina cells;GO:0007626 locomotory behavior;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RYG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RYJ8-1", "uniprot_id": "ESRP2_RAT", "mass": 77241.0, "length": 716, "protein_name": "Epithelial splicing regulatory protein 2", "gene_name": "Esrp2", "organism": "Rat", "refseq_name": "epithelial splicing regulatory protein 2 isoform X2", "refseq_ac": "XP_006255558", "gene_names_uniprotkb": "Esrp2; Rbm35b", "gene_names_refseq": "Esrp2; RGD1310855; Rbm35b", "protein_names_uniprotkb": "Epithelial splicing regulatory protein 2; RNA-binding motif protein 35B; RNA-binding protein 35B", "protein_names_refseq": "epithelial splicing regulatory protein 2 isoform X2", "tax_id": 10116, "disease": "", "pathway": " (rno:307810); (R-RNO-6803529)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0043484 regulation of RNA splicing;GO:0050679 positive regulation of epithelial cell proliferation;GO:0060445 branching involved in salivary gland morphogenesis;GO:0060441 epithelial tube branching involved in lung morphogenesis;GO:0000380 alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RYN2-1", "uniprot_id": "FBX31_RAT", "mass": 57399.0, "length": 507, "protein_name": "F-box only protein 31", "gene_name": "Fbxo31", "organism": "Rat", "refseq_name": "F-box only protein 31 isoform 1", "refseq_ac": "NP_001037724", "gene_names_uniprotkb": "Fbxo31", "gene_names_refseq": "Fbxo31; RGD1561069", "protein_names_uniprotkb": "F-box only protein 31", "protein_names_refseq": "F-box only protein 31 isoform 1; F-box only protein 31", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 45 (Disease Ontology:DOID:0081209)", "pathway": " (rno:498959); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;23469015", "class_list": "", "function": "Substrate-recognition component of the SCF(FBXO31) protein ligase complex, which specifically mediates the ubiquitination of proteins amidated at their C-terminus in response to oxidative stress, leading to their degradation by the proteasome. FBXO31 specifically recognizes and binds C-terminal peptides bearing an amide: C-terminal amidation in response to oxidative stress takes place following protein fragmentation. The SCF(FBXO31) also plays a role in G1 arrest following DNA damage by mediating ubiquitination of phosphorylated cyclin-D1 (CCND1), promoting its degradation by the proteasome, resulting in G1 arrest (By similarity). The SCF(FBXO31) complex is however not a major regulator of CCND1 stability during the G1/S transition (By similarity). In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated MDM2, thereby promoting p53/TP53-mediated DNA damage response. SCF(FBXO31) complex is required for genomic integrity by catalyzing ubiquitination and degradation of cyclin-A (CCNA1 and/or CCNA2) during the G1 phase. In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated FBXO46 and MAP2K6. SCF(FBXO31) complex promotes ubiquitination and degradation of CDT1 during the G2 phase to prevent re-replication. The SCF(FBXO31) complex also mediates ubiquitination and degradation of DUSP6, OGT and PARD6A (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0043025 neuronal cell body;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0034599 cellular response to oxidative stress;GO:0042770 signal transduction in response to DNA damage;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B2RYN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RYW9-1", "uniprot_id": "FAH2A_RAT", "mass": 34581.0, "length": 313, "protein_name": "Oxaloacetate tautomerase Fahd2a, mitochondrial", "gene_name": "Fahd2a", "organism": "Rat", "refseq_name": "oxaloacetate tautomerase Fahd2a, mitochondrial", "refseq_ac": "NP_001128306", "gene_names_uniprotkb": "Fahd2a", "gene_names_refseq": "Fahd2a; Fahd2; RGD1563674", "protein_names_uniprotkb": "Oxaloacetate tautomerase Fahd2a, mitochondrial; 5.3.2.2; Fumarylacetoacetate hydrolase domain-containing protein 2A", "protein_names_refseq": "fumarylacetoacetate hydrolase domain-containing protein 2A; fumarylacetoacetate hydrolase domain-containing protein 2; oxaloacetate tautomerase Fahd2a, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:296131)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.3.2.2;3.7.1.5;4.1.1.112", "go_molecular_function": "GO:0046872 metal ion binding;GO:0050163 oxaloacetate tautomerase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006107 oxaloacetate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RZ17-1", "uniprot_id": "FBXW2_RAT", "mass": 51408.0, "length": 454, "protein_name": "F-box/WD repeat-containing protein 2", "gene_name": "Fbxw2", "organism": "Rat", "refseq_name": "F-box/WD repeat-containing protein 2", "refseq_ac": "NP_001101305", "gene_names_uniprotkb": "Fbxw2", "gene_names_refseq": "Fbxw2", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 2; F-box and WD-40 domain-containing protein 2; Protein MD6", "protein_names_refseq": "F-box and WD-40 domain protein 2; F-box and WD-40 domain-containing protein 2; F-box/WD repeat-containing protein 2; protein MD6", "tax_id": 10116, "disease": "", "pathway": " (rno:311881); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RZ17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RZ42-1", "uniprot_id": "ALKL2_RAT", "mass": 17428.0, "length": 151, "protein_name": "ALK and LTK ligand 2", "gene_name": "Alkal2", "organism": "Rat", "refseq_name": "ALK and LTK ligand 2 precursor", "refseq_ac": "NP_001102842", "gene_names_uniprotkb": "Alkal2", "gene_names_refseq": "Alkal2; Fam150b", "protein_names_uniprotkb": "ALK and LTK ligand 2", "protein_names_refseq": "ALK and LTK ligand 2 precursor; family with sequence similarity 150, member B; protein FAM150B", "tax_id": 10116, "disease": "", "pathway": " (rno:679566); (R-RNO-201556); (R-RNO-9842663)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation. Cytokine-binding is sufficient to activate LTK. In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK. Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0030971 receptor tyrosine kinase binding;GO:0030298 receptor signaling protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0097485 neuron projection guidance;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0042594 response to starvation;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RZ42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5DEH2-1", "uniprot_id": "ERLN2_RAT", "mass": 37710.0, "length": 339, "protein_name": "Erlin-2", "gene_name": "Erlin2", "organism": "Rat", "refseq_name": "erlin-2", "refseq_ac": "NP_001099558", "gene_names_uniprotkb": "Erlin2; Spfh2", "gene_names_refseq": "Erlin2; RGD1309010; Spfh2", "protein_names_uniprotkb": "Erlin-2; Endoplasmic reticulum lipid raft-associated protein 2; SPFH domain-containing protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2", "protein_names_refseq": "SPFH domain family, member 2; SPFH domain-containing protein 2; endoplasmic reticulum lipid raft-associated protein 2; erlin-2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2", "tax_id": 10116, "disease": "hereditary spastic paraplegia 18A (Disease Ontology:DOID:0070640); hereditary spastic paraplegia 18B (Disease Ontology:DOID:0070641); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:290823); (R-RNO-382556); (R-RNO-9931269)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19240031;22771797", "class_list": "", "function": "A novel brain gamma-secretase associated protein , erlin-2, that resides in detergent resistant membranes and affects amyloid beta-peptide production., [RefSeq, PubMed]; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results suggest that this novel SPFH1/2 complex is a recognition factor that targets IP(3)Rs and perhaps other substrates for ERAD., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0045121 membrane raft;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0045540 regulation of cholesterol biosynthetic process;GO:0036503 ERAD pathway;GO:0045541 negative regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B5DEH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZAT9-1", "uniprot_id": "FAXC_RAT", "mass": 46838.0, "length": 409, "protein_name": "Failed axon connections homolog", "gene_name": "Faxc", "organism": "Rat", "refseq_name": "failed axon connections homolog", "refseq_ac": "NP_001257994", "gene_names_uniprotkb": "Faxc", "gene_names_refseq": "Faxc; RGD1562449", "protein_names_uniprotkb": "Failed axon connections homolog", "protein_names_refseq": "failed axon connections homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:366333)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in axonal development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZAT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZF18-1", "uniprot_id": "CK097_RAT", "mass": 13981.0, "length": 124, "protein_name": "Uncharacterized protein C11orf97 homolog", "gene_name": "C8h11orf97", "organism": "Rat", "refseq_name": "uncharacterized protein C11orf97 homolog", "refseq_ac": "NP_001102759", "gene_names_uniprotkb": "C8h11orf97; RGD1561795", "gene_names_refseq": "C8h11orf97; RGD1561795", "protein_names_uniprotkb": "Uncharacterized protein C11orf97 homolog", "protein_names_refseq": "uncharacterized protein C11orf97 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500945)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12947022", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036064 ciliary basal body;GO:0097546 ciliary base", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZF18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZF77-1", "uniprot_id": "AK1CA_RAT", "mass": 37195.0, "length": 324, "protein_name": "Aldo-keto reductase family 1 member C15", "gene_name": "Akr1c15; Akr1c8", "organism": "Rat", "refseq_name": "aldo-keto reductase family 1 member C15", "refseq_ac": "NP_001103370", "gene_names_uniprotkb": "Akr1c15; Akr1c8; Akr1cl", "gene_names_refseq": "17beta-HSD; Akr1c15; Akr1c8; Akr1cl1; Akr1cl; RAKc", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member C15; 1.1.1.-; 1.1.1.216; RAKc", "protein_names_refseq": "aldo-keto reductase family 1 member C15; aldo-keto reductase family 1, member C-like 1; aldo-keto reductase family 1, member C15", "tax_id": 10116, "disease": "", "pathway": " (rno:361267)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17574202;21187079;21187080;7511002", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of a variety of substrates including aromatic and aliphatic aldehydes, quinones, ketones, dicarbonyl compounds and 17-ketosteroids (PubMed:17574202). Catalyzes the NADP(+)-dependent oxidation of aromatic, alicyclic and aliphatic alcohols, and 17beta-hydroxysteroids (PubMed:17574202). To a lesser extent, can also catalyze the reduction of some aldoses and ketoses and the oxidation of some sugar alcohols (PubMed:17574202). In the stomach, lung and colon tissues, mediates the reduction of farnesal and geranylgeranial into farnesol and geranylgeraniol respectively (PubMed:21187079). By reducing 4-hydroxy-2-nonenal (HNE), produced during lipid peroxidation, into 1,4-dihydro-2-nonene (DHN), protects vascular endothelial cells from damage elicited by oxidized lipoproteins (PubMed:21187080)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.-;1.1.1.216", "go_molecular_function": "GO:0016229 steroid dehydrogenase activity;GO:0004032 aldose reductase (NADPH) activity;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0047086 ketosteroid monooxygenase activity;GO:0047886 farnesol dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008202 steroid metabolic process;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZF77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZG52-1", "uniprot_id": "DNA2_RAT", "mass": 119588.0, "length": 1059, "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2", "gene_name": "Dna2; Slc25a16", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dna2; Slc25a16; Slc25a16", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA replication ATP-dependent helicase/nuclease DNA2; DNA 5'-3' helicase DNA2; DNA replication ATP-dependent helicase-like homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); isolated growth hormone deficiency type IA (Disease Ontology:DOID:0060873); Seckel syndrome 8 (Disease Ontology:DOID:0070009); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6 (Disease Ontology:DOID:0111519); cancer (Disease Ontology:DOID:162); Bloom syndrome (Disease Ontology:DOID:2717); Werner syndrome (Disease Ontology:DOID:5688); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (rno:309762); (rno:361836); (R-RNO-174437); (R-RNO-5685938); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5693568); (R-RNO-5693579); (R-RNO-5693607); (R-RNO-5693616); (R-RNO-6804756); (R-RNO-69166); (R-RNO-69473)", "pathway_count": 13, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is absent to weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function (By similarity)., [UniProtKB, UniProtKB]; Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA., [UniProtKB, UniProtKB]; Mitochondrial inner membrane transporter that regulates coenzyme A homeostasis between cytosol and mitochondria. Could mediate the import of coenzyme A from the cytosol into the mitochondrial matrix. Alternatively, it could function in the export of 3'-dephospho-CoA from the mitochondrial matrix to the cytosol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.1.4.-;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0032201 telomere maintenance via semi-conservative replication;GO:0006284 base-excision repair;GO:0006260 DNA replication;GO:0000729 DNA double-strand break processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZG52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZHR2-1", "uniprot_id": "ABCD1_RAT", "mass": 81938.0, "length": 737, "protein_name": "ATP-binding cassette sub-family D member 1", "gene_name": "Abcd1", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family D member 1", "refseq_ac": "NP_001102291", "gene_names_uniprotkb": "Abcd1", "gene_names_refseq": "ALDP; Abcd1; RGD1562128", "protein_names_uniprotkb": "ATP-binding cassette sub-family D member 1; 3.1.2.-; 7.6.2.-; ALDP; Adrenoleukodystrophy protein", "protein_names_refseq": "ATP-binding cassette sub-family D member 1; ATP-binding cassette, sub-family D (ALD), member 1; ATP-binding cassette, subfamily D (ALD), member 1; adrenoleukodystrophy protein", "tax_id": 10116, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (rno:363516); (R-RNO-1369062); (R-RNO-2046105); (R-RNO-2046106); (R-RNO-390247); (R-RNO-9603798)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "12176987;25043761;28258215", "class_list": "", "function": "ABCD1 and its homolog ABCD2 exist mainly as homotetramers in the peroxisomal membrane, [RefSeq, PubMed]; ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:12176987). Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (By similarity). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:25043761). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.-;7.6.2.-;2.3.2.27;2.3.2.36;1.2.1.3;1.2.1.94;7.4.2.-;3.1.2.2;3.1.2.27;2.3.1.65", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0031966 mitochondrial membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0051900 regulation of mitochondrial depolarization;GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0032000 positive regulation of fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZHR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZKD3-1", "uniprot_id": "ALKB5_RAT", "mass": 44453.0, "length": 395, "protein_name": "RNA demethylase ALKBH5", "gene_name": "Alkbh5", "organism": "Rat", "refseq_name": "RNA demethylase ALKBH5", "refseq_ac": "NP_001178572", "gene_names_uniprotkb": "Alkbh5", "gene_names_refseq": "Alkbh5; RGD1309496", "protein_names_uniprotkb": "RNA demethylase ALKBH5; 1.14.11.53; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5", "protein_names_refseq": "AlkB family member 5, RNA demethylase; RNA demethylase ALKBH5; alkB, alkylation repair homolog 5; alkylated DNA repair protein alkB homolog 5; alpha-ketoglutarate-dependent dioxygenase alkB homolog 5", "tax_id": 10116, "disease": "", "pathway": " (rno:303193); (R-RNO-73943)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "22673903;29393594;37584615;38285939;38331303;38734267;38764325", "class_list": "", "function": "ALKBH5 modulates bone cancer pain in a rat model by suppressing NR2B expression., [RefSeq, PubMed]; ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in hyperbilirubinemia-induced brain damage., [RefSeq, PubMed]; ALKBH5-Mediated RNA m[6] A Methylation Regulates the Migration, Invasion, and Proliferation of Rheumatoid Fibroblast-Like Synoviocytes., [RefSeq, PubMed]; Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Demethylation of m6A mRNA affects mRNA processing, translation and export (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (By similarity). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (By similarity). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m[6]A-dependent stabilization of 5-HT3A mRNA in sensory neurons., [RefSeq, PubMed]; Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.53;1.14.11.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0035515 oxidative RNA demethylase activity;GO:1990931 mRNA N6-methyladenosine dioxygenase activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0042382 paraspeckles", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "D3ZKD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZKU7-1", "uniprot_id": "BL1S1_RAT", "mass": 14311.0, "length": 125, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 1", "gene_name": "Bloc1s1; Rdh5", "organism": "Rat", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 1", "refseq_ac": "NP_001099411", "gene_names_uniprotkb": "Bloc1s1; Rdh5; Bloc1s1; Rdh5", "gene_names_refseq": "Bloc1s1", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 1; 2.3.1.-; BLOC-1 subunit 1; Protein acetyltransferase BLOC1S1", "protein_names_refseq": "BLOC-1 subunit 1; biogenesis of lysosome-related organelles complex 1 subunit 1; protein acetyltransferase BLOC1S1", "tax_id": 10116, "disease": "fundus albipunctatus (Disease Ontology:DOID:11105); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); schizophrenia (Disease Ontology:DOID:5419); night blindness (Disease Ontology:DOID:8499); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (rno:288785); (rno:366791); (R-RNO-432720); (R-RNO-432722)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "15496412;28526709;31033247", "class_list": "", "function": "Acetylation of cardiac mitochondrial fatty acid oxidation enzymes by GCN5L1 significantly upregulates their activity in diet-induced obese mice., [RefSeq, PubMed]; Acts as a protein acetyltransferase. Negatively regulates aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. Acts as a regulator of mTORC2 signaling in response to hypotoxic stress by mediating acetylation of RICTOR, thereby protecting RICTOR against ubiquitination and subsequent degradation by the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor., [UniProtKB, UniProtKB]; Loss of GCN5L1 activity under hyperglycemic conditions impairs cardiac energy metabolism., [RefSeq, PubMed]; NGF receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of PCAF and hGCN5 acetyltransferases, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48;5.3.4.1;2.3.1.-;3.6.5.5;3.6.4.10;3.6.5.2;2.7.11.1;2.7.11.4;2.3.1.259;2.3.1.80;3.1.22.1;3.4.18.1", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0042803 protein homodimerization activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0016197 endosomal transport;GO:0008089 anterograde axonal transport;GO:0048490 anterograde synaptic vesicle transport;GO:0032418 lysosome localization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZKU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZLY0-1", "uniprot_id": "ACKMT_RAT", "mass": 24053.0, "length": 216, "protein_name": "ATP synthase subunit C lysine N-methyltransferase", "gene_name": "Atpsckmt", "organism": "Rat", "refseq_name": "ATP synthase subunit C lysine N-methyltransferase", "refseq_ac": "NP_001102648", "gene_names_uniprotkb": "Atpsckmt; Fam173b", "gene_names_refseq": "Atpsckmt; Fam173b; RGD1560629", "protein_names_uniprotkb": "ATP synthase subunit C lysine N-methyltransferase; 2.1.1.-; Protein N-lysine methyltransferase FAM173B", "protein_names_refseq": "ATP synthase subunit C lysine N-methyltransferase; family with sequence similarity 173, member B; protein FAM173B; protein N-lysine methyltransferase FAM173B", "tax_id": 10116, "disease": "", "pathway": " (rno:499561)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30530489", "class_list": "", "function": "Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (Probable). Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.-;2.1.1.359;2.1.1.372", "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0018022 peptidyl-lysine methylation;GO:0018023 peptidyl-lysine trimethylation;GO:1904058 positive regulation of sensory perception of pain;GO:1905273 positive regulation of proton-transporting ATP synthase activity, rotational mechanism;GO:1905706 regulation of mitochondrial ATP synthesis coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZLY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZVB0-1", "uniprot_id": "AP5B1_RAT", "mass": 94764.0, "length": 876, "protein_name": "AP-5 complex subunit beta-1", "gene_name": "Ap5b1", "organism": "Rat", "refseq_name": "AP-5 complex subunit beta-1", "refseq_ac": "NP_001257961", "gene_names_uniprotkb": "Ap5b1", "gene_names_refseq": "Ap5b1; Beta5; RGD1562657", "protein_names_uniprotkb": "AP-5 complex subunit beta-1; Adaptor-related protein complex 5 beta subunit; Beta5", "protein_names_refseq": "AP-5 complex subunit beta-1; adapter-related protein complex 5 beta subunit; adaptor-related protein complex 5 beta subunit; adaptor-related protein complex 5, beta 1 subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:361709)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As part of AP-5, a probable fifth adaptor protein complex, it may be involved in endosomal transport., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030119 AP-type membrane coat adaptor complex", "go_biological_process": "GO:0015031 protein transport;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZYW7-1", "uniprot_id": "FRDA_RAT", "mass": 23066.0, "length": 208, "protein_name": "Frataxin, mitochondrial", "gene_name": "Fxn", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fxn", "gene_names_refseq": "", "protein_names_uniprotkb": "Frataxin, mitochondrial; 1.16.3.1; Fxn", "protein_names_refseq": "", "tax_id": 10116, "disease": "Friedreich ataxia 1 (Disease Ontology:DOID:0111218); Friedreich ataxia (Disease Ontology:DOID:12705); cancer (Disease Ontology:DOID:162); iron metabolism disease (Disease Ontology:DOID:2351); glioblastoma (Disease Ontology:DOID:3068); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:499335); (R-RNO-1268020); (R-RNO-1362409); (R-RNO-9854311); (R-RNO-9865881)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "15247478", "class_list": "", "function": "Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly. Accelerates sulfur transfer from NFS1 persulfide intermediate to ISCU and to small thiols such as L-cysteine and glutathione leading to persulfuration of these thiols and ultimately sulfide release. Binds ferrous ion and is released from FXN upon the addition of both L-cysteine and reduced FDX2 during [2Fe-2S] cluster assembly (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems (By similarity). May function as an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation (PubMed:15247478). May play a role as a high affinity iron binding partner for FECH that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Modulates the RNA-binding activity of ACO1. May be involved in the cytoplasmic iron-sulfur protein biogenesis. May contribute to oxidative stress resistance and overall cell survival., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.16.3.1;2.1.3.3;7.1.2.2;1.11.1.27;1.11.1.9;1.16.3.4;7.1.1.8;1.3.5.1;1.1.5.-;3.6.4.10;5.6.1.7;2.5.1.39;2.8.1.7;4.2.1.3", "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0019899 enzyme binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0008198 ferrous iron binding;GO:0004322 ferroxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0099128 mitochondrial [2Fe-2S] assembly complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0046621 negative regulation of organ growth;GO:0009792 embryo development ending in birth or egg hatching;GO:0010888 negative regulation of lipid storage;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZYW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A1R8-1", "uniprot_id": "CPNE1_RAT", "mass": 58844.0, "length": 536, "protein_name": "Copine-1", "gene_name": "Cpne1", "organism": "Rat", "refseq_name": "copine-1", "refseq_ac": "NP_001243394", "gene_names_uniprotkb": "Cpne1", "gene_names_refseq": "Cpne1", "protein_names_uniprotkb": "Copine-1; Copine I", "protein_names_refseq": "copine I; copine-1-like; copine-1", "tax_id": 10116, "disease": "", "pathway": " (rno:362249); (R-RNO-1483206); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11123945;23263657;25450385;29393594;32958249;37132099", "class_list": "", "function": "CPNE1-mediated neuronal differentiation can be inhibited by HAX1 expression in HiB5 cells., [RefSeq, PubMed]; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL., [UniProtKB, UniProtKB]; Copine 1 enhances neuronal differentiation of HiB5 cells not through the PI3K-Akt pathway, but by using another Akt activated signal pathway., [RefSeq, PubMed]; Role of CPNE1 in Odontoblastic Differentiation of Rat Stem Cells from Apical Papilla., [RefSeq, PubMed]; The C2 domains of CPNE1 play a calcium-independent role in regulating the neuronal differentiation of HiB5 hippocampal progenitor cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZSJ8;H1UBM6", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0051059 NF-kappaB binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0010629 negative regulation of gene expression;GO:0045666 positive regulation of neuron differentiation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D4A1R8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A2Z2-1", "uniprot_id": "EPPI_RAT", "mass": 15684.0, "length": 134, "protein_name": "Eppin", "gene_name": "Eppin", "organism": "Rat", "refseq_name": "eppin precursor", "refseq_ac": "NP_001102927", "gene_names_uniprotkb": "Eppin; Spinlw1", "gene_names_refseq": "Eppin; Spinlw1; Wfdc8", "protein_names_uniprotkb": "Eppin; Epididymal protease inhibitor; Serine protease inhibitor-like with Kunitz and WAP domains 1", "protein_names_refseq": "WAP four-disulfide core domain protein 8; epididymal protease inhibitor; eppin precursor; serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin); serine protease inhibitor-like with Kunitz and WAP domains 1; serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin)", "tax_id": 10116, "disease": "", "pathway": " (rno:685161); (R-RNO-6803157)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23070980", "class_list": "", "function": "Data suggested that EPPIN expression in rats is more widespread than in humans and mice, and is androgen-dependent in the epididymis; findings provide new insights into its potential physiological roles in reproduction, [RefSeq, PubMed]; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0001669 acrosomal vesicle;GO:0032991 protein-containing complex", "go_biological_process": "GO:0090281 negative regulation of calcium ion import;GO:1901318 negative regulation of flagellated sperm motility;GO:0010466 negative regulation of peptidase activity;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A2Z2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A4D7-1", "uniprot_id": "E2F7_RAT", "mass": 99029.0, "length": 902, "protein_name": "Transcription factor E2F7", "gene_name": "E2f7", "organism": "Rat", "refseq_name": "transcription factor E2F7", "refseq_ac": "NP_001101562", "gene_names_uniprotkb": "E2f7", "gene_names_refseq": "E2F-7; E2f7", "protein_names_uniprotkb": "Transcription factor E2F7; E2F-7", "protein_names_refseq": "transcription factor E2F7", "tax_id": 10116, "disease": "", "pathway": " (rno:314818); (R-RNO-6804116)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18541936", "class_list": "", "function": "Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation (By similarity)., [UniProtKB]; E2F transcription factor genes and their 34 target genes have a role in liver regeneration., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:0060718 chorionic trophoblast cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A4D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A612-1", "uniprot_id": "ELOV2_RAT", "mass": 32417.0, "length": 279, "protein_name": "Very long chain fatty acid elongase 2", "gene_name": "Elovl2", "organism": "Rat", "refseq_name": "very long chain fatty acid elongase 2 isoform 1", "refseq_ac": "NP_001102588", "gene_names_uniprotkb": "Elovl2; ELOVL2; Ssc2", "gene_names_refseq": "Elovl2", "protein_names_uniprotkb": "Very long chain fatty acid elongase 2; 2.3.1.199; 3-keto acyl-CoA synthase Elovl2; ELOVL FA elongase 2; ELOVL fatty acid elongase 2; Elongation of very long chain fatty acids protein 2; Very long chain 3-ketoacyl-CoA synthase 2; Very long chain 3-oxoacyl-CoA synthase 2", "protein_names_refseq": "3-keto acyl-CoA synthase Elovl2; ELOVL FA elongase 2; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2; elongation of very long chain fatty acids protein 2; elongation of very long chain fatty acids-like 2; very long chain 3-ketoacyl-CoA synthase 2; very long chain 3-oxoacyl-CoA synthase 2; very long chain fatty acid elongase 2 isoform 1; very long chain fatty acid elongase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:498728); (R-RNO-2046105); (R-RNO-2046106); (R-RNO-75876)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "22216341;23873268", "class_list": "", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, HAMAP, PubMed, PubMed, UniProtKB, UniProtKB]; Elovl2 C217 is a critical residue for elongation of docosapentaenoic acid at the level observed in the native protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A612-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88884-1", "uniprot_id": "AKAP1_RAT", "mass": 91747.0, "length": 854, "protein_name": "A-kinase anchor protein 1, mitochondrial", "gene_name": "Akap1", "organism": "Rat", "refseq_name": "A-kinase anchor protein 1, mitochondrial", "refseq_ac": "NP_446117", "gene_names_uniprotkb": "Akap1; Akap", "gene_names_refseq": "AKAP 121; Akap1; Akap84; D-AKAP-1; PRKA1; S-AKAP84", "protein_names_uniprotkb": "A-kinase anchor protein 1, mitochondrial; A-kinase anchor protein 121 kDa; AKAP 121; D-AKAP-1; Dual specificity A-kinase-anchoring protein 1; PRKA1; Protein kinase A-anchoring protein 1; S-AKAP84; Spermatid A-kinase anchor protein 84", "protein_names_refseq": "A kinase (PRKA) anchor protein 1; A-kinase anchor protein 1, mitochondrial; A-kinase anchor protein 121 kDa; a kinase anchor protein 1, mitochondrial; dual specificity A-kinase-anchoring protein 1; protein kinase A-anchoring protein 1; spermatid A-kinase anchor protein 84", "tax_id": 10116, "disease": "brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (rno:114124); (R-RNO-983231)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21526220;22673903;28100784;32108342;38850669;9722570", "class_list": "", "function": "AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission., [RefSeq, PubMed]; AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes., [RefSeq, PubMed]; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (By similarity). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The scaffold protein A kinase anchoring protein 1 brings the cAMP-dependent protein kinase A to the outer mitochondrial membrane to protect neurons from injury, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88980", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0071320 cellular response to cAMP;GO:0006915 apoptotic process;GO:0008104 intracellular protein localization;GO:0042308 negative regulation of protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88884-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AAA5-1", "uniprot_id": "FAP20_RAT", "mass": 20005.0, "length": 184, "protein_name": "Fanconi anemia core complex-associated protein 20", "gene_name": "Faap20", "organism": "Rat", "refseq_name": "Fanconi anemia core complex-associated protein 20", "refseq_ac": "NP_001102168", "gene_names_uniprotkb": "Faap20", "gene_names_refseq": "Faap20; RGD1308923", "protein_names_uniprotkb": "Fanconi anemia core complex-associated protein 20; FANCA-associated protein of 20 kDa; Fanconi anemia-associated protein of 20 kDa", "protein_names_refseq": "FANCA-associated protein of 20 kDa; Fanconi anemia core complex associated protein 20; Fanconi anemia core complex-associated protein 20; Fanconi anemia-associated protein of 20 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:362678); (R-RNO-6783310); (R-RNO-9833482)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0006974 DNA damage response;GO:0036297 interstrand cross-link repair;GO:0019985 translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AAA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AB34-1", "uniprot_id": "ERFE_RAT", "mass": 36369.0, "length": 341, "protein_name": "Erythroferrone", "gene_name": "Erfe", "organism": "Rat", "refseq_name": "erythroferrone precursor", "refseq_ac": "NP_001364009", "gene_names_uniprotkb": "Erfe; C1qtnf15; Ctrp15; Fam132b", "gene_names_refseq": "Erfe; Fam132b", "protein_names_uniprotkb": "Erythroferrone; Complement C1q tumor necrosis factor-related protein 15; Myonectin", "protein_names_refseq": "complement C1q tumor necrosis factor-related protein 15; erythroferrone precursor; family with sequence similarity 132, member B; myonectin; protein FAM132B; rCG55642-like", "tax_id": 10116, "disease": "", "pathway": " (rno:681056)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22351773;24187137;28282554;30566056", "class_list": "", "function": "Erythropoietin administration increases splenic erythroferrone protein content and liver TMPRSS6 protein content in rats, [RefSeq, PubMed]; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (By similarity). Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (PubMed:22351773). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (PubMed:30566056). Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (PubMed:24187137). Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (By similarity). The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005179 hormone activity;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006879 intracellular iron ion homeostasis;GO:0019217 regulation of fatty acid metabolic process;GO:0010507 negative regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4AB34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ABB4-1", "uniprot_id": "FXL15_RAT", "mass": 33180.0, "length": 300, "protein_name": "F-box/LRR-repeat protein 15", "gene_name": "Fbxl15", "organism": "Rat", "refseq_name": "F-box/LRR-repeat protein 15", "refseq_ac": "NP_001101073", "gene_names_uniprotkb": "Fbxl15", "gene_names_refseq": "Fbxl15; RGD1306444", "protein_names_uniprotkb": "F-box/LRR-repeat protein 15", "protein_names_refseq": "F-box only protein 37; F-box/LRR-repeat protein 15", "tax_id": 10116, "disease": "", "pathway": " (rno:309453); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21572392", "class_list": "", "function": "FBXL15 is a key regulator of BMP signalling during embryonic development and adult bone formation. Erratum:[EMBO J. 2011;30(13):2748] Publication Status: Online-Only, [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0030513 positive regulation of BMP signaling pathway;GO:0009953 dorsal/ventral pattern formation;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4ABB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ABH7-1", "uniprot_id": "BN3D2_RAT", "mass": 32002.0, "length": 285, "protein_name": "RNA 5'-monophosphate methyltransferase", "gene_name": "Bcdin3d", "organism": "Rat", "refseq_name": "RNA 5'-monophosphate methyltransferase", "refseq_ac": "NP_001102221", "gene_names_uniprotkb": "Bcdin3d", "gene_names_refseq": "Bcdin3d; RGD1306433", "protein_names_uniprotkb": "RNA 5'-monophosphate methyltransferase; 2.1.1.-; BCDIN3 domain-containing protein", "protein_names_refseq": "BCDIN3 domain containing RNA methyltransfease; BCDIN3 domain-containing protein; RNA 5'-monophosphate methyltransferase; pre-miRNA 5'-monophosphate methyltransferase; probable methyltransferase BCDIN3D", "tax_id": 10116, "disease": "", "pathway": " (rno:363001)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0090486 small RNA 2'-O-methyltransferase activity;GO:0008175 tRNA methyltransferase activity;GO:0008171 O-methyltransferase activity;GO:0070883 pre-miRNA binding;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0031054 pre-miRNA processing;GO:0030488 tRNA methylation;GO:0001510 RNA methylation;GO:2000632 negative regulation of pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ABH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4ABP9-1", "uniprot_id": "FBX3_RAT", "mass": 55355.0, "length": 480, "protein_name": "F-box only protein 3", "gene_name": "Fbxo3", "organism": "Rat", "refseq_name": "F-box only protein 3", "refseq_ac": "NP_001103076", "gene_names_uniprotkb": "Fbxo3; Fbx3", "gene_names_refseq": "Fbxo3", "protein_names_uniprotkb": "F-box only protein 3", "protein_names_refseq": "F-box only protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:690634)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26674878;35962723;36362432", "class_list": "", "function": "E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury. Publication Status: Online-Only, [RefSeq, PubMed]; F-box protein 3 modifies the neuropathic pain pathway by inhibiting F-box and leucine-rich repeat protein 2-mediated TRAF2 ubiquitination, [RefSeq, PubMed]; MiR-219a-5p inhibits the pyroptosis in knee osteoarthritis by inactivating the NLRP3 signaling via targeting FBXO3., [RefSeq, PubMed]; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS) (By similarity). The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0016567 protein ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4ABP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4AEP3-1", "uniprot_id": "F168B_RAT", "mass": 20194.0, "length": 194, "protein_name": "Myelin-associated neurite-outgrowth inhibitor", "gene_name": "Fam168b", "organism": "Rat", "refseq_name": "myelin-associated neurite-outgrowth inhibitor", "refseq_ac": "NP_001258063", "gene_names_uniprotkb": "Fam168b", "gene_names_refseq": "Fam168b", "protein_names_uniprotkb": "Myelin-associated neurite-outgrowth inhibitor; Mani", "protein_names_refseq": "mani; myelin-associated neurite-outgrowth inhibitor; protein FAM168B", "tax_id": 10116, "disease": "", "pathway": " (rno:690188)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20716133;22771904", "class_list": "", "function": "Considering the protein structure of Mani obtained via a series of bio-computational studies, we propose a Cdc27-Mani-APC-related signalling pathway may be involved in CNS axon regeneration., [RefSeq, PubMed]; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007409 axonogenesis;GO:0030182 neuron differentiation;GO:0022008 neurogenesis;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4AEP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PU17-1", "uniprot_id": "ABCAH_RAT", "mass": 199859.0, "length": 1773, "protein_name": "ATP-binding cassette sub-family A member 17", "gene_name": "Abca17", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family A member 17", "refseq_ac": "NP_001026807", "gene_names_uniprotkb": "Abca17", "gene_names_refseq": "Abca17", "protein_names_uniprotkb": "ATP-binding cassette sub-family A member 17", "protein_names_refseq": "ATP-binding cassette sub-family A member 17; ATP-binding cassette, sub-family A (ABC1), member 17", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:287112)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15810880", "class_list": "", "function": "Promotes cholesterol efflux from sperm which renders sperm capable of fertilization. Has also been shown to decrease levels of intracellular esterified neutral lipids including cholesteryl esters, fatty acid esters and triacylglycerols., [UniProtKB, UniProtKB]; The cloning and characterization of ABCA17 is reported., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4H493", "ec_number_list": "7.6.2.1;7.6.2.2;7.6.2.-", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PU17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LN46-1", "uniprot_id": "CPT1C_RAT", "mass": 90170.0, "length": 801, "protein_name": "Palmitoyl thioesterase CPT1C", "gene_name": "Cpt1c", "organism": "Rat", "refseq_name": "palmitoyl thioesterase CPT1C", "refseq_ac": "NP_001030097", "gene_names_uniprotkb": "Cpt1c", "gene_names_refseq": "CPT I-C; CPT IC; CPT1-B; CPTI-B; Cpt1c", "protein_names_uniprotkb": "Palmitoyl thioesterase CPT1C; 3.1.2.22; CPT I-C; CPT1-B; CPTI-B; Carnitine O-palmitoyltransferase 1, brain isoform; Carnitine O-palmitoyltransferase I, brain isoform; Carnitine palmitoyltransferase 1C; Carnitine palmitoyltransferase I", "protein_names_refseq": "carnitine palmitoyltransferase I; palmitoyl thioesterase CPT1C", "tax_id": 10116, "disease": "hereditary spastic paraplegia 73 (Disease Ontology:DOID:0110818)", "pathway": " (rno:308579)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18192268;18385088;24222496", "class_list": "", "function": "Accumulation of 3-hydroxylated intermediates of long-chain fatty acids may contribute to the pathogenesis of retinopathy in MTP deficiencies., [RefSeq, PubMed]; CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity Erratum:[J Biol Chem. 2008 May 2;283(18):12680], [RefSeq, PubMed]; Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion., [UniProtKB, UniProtKB]; Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1 (By similarity). Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (By similarity). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control (By similarity). Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels (PubMed:18192268, PubMed:24222496)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.22;2.3.1.21;2.3.1.-;3.1.2.2;3.1.2.-;3.4.-.-;3.1.1.93;3.4.19.12", "go_molecular_function": "GO:0004095 carnitine O-palmitoyltransferase activity;GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0030424 axon;GO:0030425 dendrite;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009437 carnitine metabolic process;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels;GO:0006635 fatty acid beta-oxidation;GO:0015909 long-chain fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1LN46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35827-1", "uniprot_id": "APBB3_RAT", "mass": 54907.0, "length": 504, "protein_name": "Amyloid-beta A4 precursor protein-binding family B member 3", "gene_name": "Apbb3", "organism": "Rat", "refseq_name": "amyloid-beta A4 precursor protein-binding family B member 3", "refseq_ac": "NP_446409", "gene_names_uniprotkb": "Apbb3; Fe65l2", "gene_names_refseq": "Apbb3; Fe65l2", "protein_names_uniprotkb": "Amyloid-beta A4 precursor protein-binding family B member 3; Fe65L2; Protein Fe65-like 2", "protein_names_refseq": "amyloid beta (A4) precursor protein-binding, family B, member 3; amyloid-beta A4 precursor protein-binding family B member 3; fe65-like protein 2; protein Fe65-like 2", "tax_id": 10116, "disease": "", "pathway": " (rno:117026)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9461550", "class_list": "", "function": "May modulate the internalization of amyloid-beta precursor protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0050750 low-density lipoprotein particle receptor binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0050714 positive regulation of protein secretion;GO:1901988 negative regulation of cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35827-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88277-1", "uniprot_id": "FAT2_RAT", "mass": 480654.0, "length": 4351, "protein_name": "Protocadherin Fat 2", "gene_name": "Fat2", "organism": "Rat", "refseq_name": "protocadherin Fat 2 precursor", "refseq_ac": "NP_075243", "gene_names_uniprotkb": "Fat2; Fath2; Megf1", "gene_names_refseq": "Fat2; Fath2", "protein_names_uniprotkb": "Protocadherin Fat 2; Multiple EGF-like domains protein 1; Multiple epidermal growth factor-like domains protein 1", "protein_names_refseq": "FAT tumor suppressor homolog 2; MEGF1; multiple EGF-like domains protein 1; multiple epidermal growth factor-like domains 1; multiple epidermal growth factor-like domains protein 1; protocadherin Fat 2 precursor; protocadherin Fat 2", "tax_id": 10116, "disease": "spinocerebellar ataxia 45 (Disease Ontology:DOID:0080287)", "pathway": " (rno:65048)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12213440;29053796;9693030", "class_list": "", "function": "Involved in the regulation of cell migration (PubMed:29053796). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (PubMed:12213440)., [UniProtKB, PubMed, PubMed]; Involved in the regulation of cell migration. May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development., [UniProtKB, UniProtKB]", "predicted_glycosites": 38, "predicted_n_glycosites": 37, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 38, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0010631 epithelial cell migration;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031589 cell-substrate adhesion;GO:0044331 cell-cell adhesion mediated by cadherin", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88277-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02529-1", "uniprot_id": "CRGC_RAT", "mass": 20951.0, "length": 174, "protein_name": "Gamma-crystallin C", "gene_name": "Crygc", "organism": "Rat", "refseq_name": "gamma-crystallin C isoform 2", "refseq_ac": "NP_001075129", "gene_names_uniprotkb": "Crygc", "gene_names_refseq": "Cryg3; Crygc; Cryg; Len", "protein_names_uniprotkb": "Gamma-crystallin C; Gamma-C-crystallin; Gamma-crystallin 2-1", "protein_names_refseq": "crystallin, gamma polypeptide 3; gamma-C-crystallin; gamma-crystallin 2-1; gamma-crystallin C isoform 2; gamma-crystallin C", "tax_id": 10116, "disease": "cataract 2 multiple types (Disease Ontology:DOID:0110235); cataract (Disease Ontology:DOID:83); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:24277)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2777080;3783678;6294661", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007601 visual perception;GO:0001654 eye development;GO:0043010 camera-type eye development;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P02529-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35460-1", "uniprot_id": "ANGP1_RAT", "mass": 57461.0, "length": 497, "protein_name": "Angiopoietin-1", "gene_name": "Angpt1", "organism": "Rat", "refseq_name": "angiopoietin-1 precursor", "refseq_ac": "NP_445998", "gene_names_uniprotkb": "Angpt1", "gene_names_refseq": "Agpt1; Agpt; Ang-1; Angpt1", "protein_names_uniprotkb": "Angiopoietin-1; ANG-1", "protein_names_refseq": "angiopoietin-1 precursor", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); stroke (Disease Ontology:DOID:0051061); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); hereditary angioedema (Disease Ontology:DOID:14735); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); nephrosis (Disease Ontology:DOID:2527); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial adenocarcinoma (Disease Ontology:DOID:2870); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); in situ carcinoma (Disease Ontology:DOID:8719); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (rno:89807); (R-RNO-210993); (R-RNO-5673001)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12458684;29197611;29774773;30729120;31581897;33820492;9776732", "class_list": "", "function": "All-trans retinoic acid regulating angiopoietins-1 and alleviating extracellular matrix accumulation in interstitial fibrosis rats., [RefSeq, PubMed]; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development., [UniProtKB]; Hyperglycemia could induce pathological angiogenesis in subcutaneous Matrigel of diabetic rats, and Ang-1 could upregulate the expression of intercellular junction protein in subcutaneous Matrigel of diabetic rats and promote the integrity of neovascularization in the subcutaneous Matrigel of diabetic rats Publication Status: Online-Only, [RefSeq, PubMed]; MiR-711-dependent downregulation of Ang-1...may play a role in neuronal cell death after neuronal injury in vitro and after experimental traumatic brain injury., [RefSeq, PubMed]; Overexpression of Ang-1 enhanced the tube formation, migration, and proliferation ability of endothelial progenitor cells. EPC transplantation facilitated occlusion of carotid aneurysms., [RefSeq, PubMed]; Published rodent data suggest that angiopoietin-1 upregulation improves outcome following temporary cerebral ischaemia by reducing cerebral infarction size and improving blood-brain barrier integrity., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4Q4", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0030971 receptor tyrosine kinase binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0045121 membrane raft;GO:0005902 microvillus", "go_biological_process": "GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0007162 negative regulation of cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35460-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LYQ8-1", "uniprot_id": "FARP1_RAT", "mass": 118842.0, "length": 1049, "protein_name": "FERM, ARHGEF and pleckstrin domain-containing protein 1", "gene_name": "Farp1", "organism": "Rat", "refseq_name": "FERM, ARHGEF and pleckstrin domain-containing protein 1", "refseq_ac": "NP_001100757", "gene_names_uniprotkb": "Farp1", "gene_names_refseq": "Farp1", "protein_names_uniprotkb": "FERM, ARHGEF and pleckstrin domain-containing protein 1; FERM, RhoGEF and pleckstrin domain-containing protein 1", "protein_names_refseq": "FERM, ARHGEF and pleckstrin domain-containing protein 1; FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived); FERM, RhoGEF and pleckstrin domain-containing protein 1; FERMRhoGEF (Arhgef) and pleckstrin domain protein 1-like", "tax_id": 10116, "disease": "", "pathway": " (rno:306183); (R-RNO-8980692); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9035034)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "22673903;23209303;24899721;38843836", "class_list": "", "function": "May play a role in semaphorin signaling (By similarity). Functions as a guanine nucleotide exchange factor for RAC1. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses., [UniProtKB, PubMed]; This study support that Farp1 signaling is necessary for the high extent of arborization of maturing dendrites., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043197 dendritic spine", "go_biological_process": "GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0007416 synapse assembly;GO:0016601 Rac protein signal transduction;GO:0048813 dendrite morphogenesis;GO:0098974 postsynaptic actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1LYQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35167-1", "uniprot_id": "COLQ_RAT", "mass": 47912.0, "length": 458, "protein_name": "Acetylcholinesterase collagenic tail peptide", "gene_name": "Colq", "organism": "Rat", "refseq_name": "acetylcholinesterase collagenic tail peptide precursor", "refseq_ac": "NP_062147", "gene_names_uniprotkb": "Colq", "gene_names_refseq": "Colq", "protein_names_uniprotkb": "Acetylcholinesterase collagenic tail peptide; AChE Q subunit; Acetylcholinesterase-associated collagen", "protein_names_refseq": "AChE Q subunit; acetylcholinesterase collagenic tail peptide precursor; acetylcholinesterase collagenic tail peptide; acetylcholinesterase-associated collagen; collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase", "tax_id": 10116, "disease": "congenital myasthenic syndrome 5 (Disease Ontology:DOID:0110667)", "pathway": " (rno:29755)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12684510;15159418;18373559;20053883;20153305;20188715;22944068;23159887;9278446", "class_list": "", "function": "AChE, BChE and PRiMA mRNA level modifications found in the absence of ColQ cannot compensate for the physiological defects observed at the ColQ-deficient neuromuscular junction., [RefSeq, PubMed]; Anchors the catalytic subunits of asymmetric AChE to the synaptic basal membrane, and is therefore involved in the down-regulation of colinergic synaptic transmission., [UniProtKB, UniProtKB]; Differential distribution of P-CREB in fast-and slow-twitch muscles might support the crucial role of cAMP-dependent signaling in controlling the synapse-specific expression of ColQ-1a in fast-twitch muscles, [RefSeq, PubMed]; Extensive neural suppression of the extrajunctional ColQ expression in regenerating fast muscles during maturation is a very slow process requiring 30-60 days., [RefSeq, PubMed]; Extrajunctional collagen Q expression in fast muscles is independent of muscle activation and is partly nerve-dependent., [RefSeq, PubMed]; Extrajunctional levels of ColQ mRNA in non-innervated regenerating fast and slow muscles, [RefSeq, PubMed]; In addition to its structural role, ColQ has important regulatory functions at the synapse by controlling acetylcholine receptor clustering through its interaction with MuSK., [RefSeq, PubMed]; Two heparin-binding domains with different properties that may have non-redundant functions are described; may coordinate acetylcholinesterase positioning within the the neuromuscular junction basal lamina., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008201 heparin binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031594 neuromuscular junction;GO:0005604 basement membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0032223 negative regulation of synaptic transmission, cholinergic;GO:0035418 protein localization to synapse;GO:0090150 establishment of protein localization to membrane;GO:0008582 regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35167-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35795-1", "uniprot_id": "ENTP2_RAT", "mass": 54390.0, "length": 495, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 2", "gene_name": "Entpd2; Npdc1", "organism": "Rat", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 2 isoform 1", "refseq_ac": "NP_742027", "gene_names_uniprotkb": "Entpd2; Npdc1; Cd39l1; Entpd2; Npdc1", "gene_names_refseq": "Cd39l1; Entpd2; NTPDase2", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 2; 3.6.1.5; CD39 antigen-like 1; Ecto-ATP diphosphohydrolase 2; Ecto-ATPDase 2; Ecto-ATPase 2; NTPDase 2", "protein_names_refseq": "CD39 antigen-like 1; NTPDase 2; ecto-ATP diphosphohydrolase 2; ecto-ATPDase 2; ecto-ATPase 2; ectonucleoside triphosphate diphosphohydrolase 2 isoform 1; nucleoside triphosphate diphosphohydrolase 2; testicular ecto-ATPase", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); primary biliary cholangitis (Disease Ontology:DOID:12236); high grade glioma (Disease Ontology:DOID:3070); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:64467); (R-RNO-8850843)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1039/D0MO00044B;10231370;10581401;11229804;15362980;18458329;23830739;24090084;26080748;34106099;35593054;38055119;38158780;38843836;9364474", "class_list": "", "function": "ADP-mediated Modulation of Intracellular Calcium Responses in Chromaffin Cells: The Role of Ectonucleoside Triphosphate Diphosphohydrolase 2 on Rat Adrenal Medulla Function., [RefSeq, PubMed]; At the transcriptional level, extracellular ATP upregulated expression of NTPDase1, NTPDase2, NPP2, and eN, while, at translational and functional levels, these were paralleled only by the induction of NTPDase2 and ecto-5'-nucleotidase., [RefSeq, PubMed]; Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs), with a marked preference for triphosphonucleosides over diphosphonucleosides (PubMed:10231370, PubMed:11229804, PubMed:15362980, PubMed:23830739, PubMed:9364474). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:10231370, PubMed:11229804, PubMed:15362980, PubMed:23830739, PubMed:9364474). This activity contributes to the regulation of extracellular nucleotides levels (PubMed:10231370, PubMed:11229804, PubMed:15362980, PubMed:23830739, PubMed:9364474). ATP hydrolysis is characterized by fast ADP accumulation and delayed AMP formation, reflecting limited ADP hydrolase activity (PubMed:10231370, PubMed:15362980). Hydrolyzes ADP and UDP only to a marginal extent, and does not hydrolyze AMP (PubMed:9364474). All nucleoside 5'-diphosphates are hydrolyzed at rates lower than those of their corresponding triphosphates (PubMed:15362980)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Expression of Ectonucleoside Triphosphate Diphosphohydrolase 2 (NTPDase2) Is Negatively Regulated Under Neuroinflammatory Conditions In Vivo and In Vitro., [RefSeq, PubMed]; Upregulation of CD39 During Gout Attacks Promotes Spontaneous Remission of Acute Gouty Inflammation., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHY5;Q9WVE7", "ec_number_list": "5.6.2.3;3.6.5.2;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;3.6.1.1;2.3.2.27;3.6.5.-;5.6.2.4;3.6.5.3;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.6.1.62;3.6.1.64;3.6.5.5;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.6.1.16;3.6.1.53;3.1.4.-;3.6.5.4;3.6.1.6;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0004382 GDP phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0044297 cell body;GO:0005604 basement membrane;GO:0031253 cell projection membrane", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0007186 G protein-coupled receptor signaling pathway;GO:0071222 cellular response to lipopolysaccharide;GO:0030168 platelet activation;GO:0010996 response to auditory stimulus", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O35795-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09178-1", "uniprot_id": "AMPD3_RAT", "mass": 88483.0, "length": 765, "protein_name": "AMP deaminase 3", "gene_name": "Ampd3", "organism": "Rat", "refseq_name": "AMP deaminase 3", "refseq_ac": "NP_113732", "gene_names_uniprotkb": "Ampd3", "gene_names_refseq": "Ampd3", "protein_names_uniprotkb": "AMP deaminase 3; 3.5.4.6; AMP deaminase isoform E", "protein_names_refseq": "AMP deaminase 3; Ampd", "tax_id": 10116, "disease": "pontocerebellar hypoplasia (Disease Ontology:DOID:0060264)", "pathway": " (rno:25095); (R-RNO-6798695); (R-RNO-74217)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "22673903;29733818;36815317;9291127", "class_list": "", "function": "AMP deaminase plays a critical role in energy metabolism., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Adenosine monophosphate deaminase in the endoplasmic reticulum-mitochondria interface promotes mitochondrial Ca[2+] overload in type 2 diabetes rat hearts., [RefSeq, PubMed]; The results indicate that translational regulation by miR-301b mediates upregulated expression of cardiac AMPD3 protein in OLETF, which potentially reduces the adenine nucleotide pool at the time of increased work load. The miR-301b-AMPD3 axis may be a novel therapeutic target for intervening enegy metabolism in diabetic hearts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.8;1.1.1.205;3.2.1.23;3.5.4.5;2.3.2.5;3.6.4.13;2.4.1.25;3.2.1.33;4.2.99.18;5.6.2.4;4.1.2.4;2.4.1.186;3.5.4.6;3.1.1.47;2.7.1.35;3.4.22.1;1.11.1.6;2.5.1.18;4.1.2.13;3.6.5.-;4.2.1.24;3.2.1.31;2.4.1.1;2.7.10.2;2.7.11.1;2.7.1.40;1.13.11.-;1.13.11.34;3.4.19.1;2.3.3.8;1.16.3.1;2.7.4.6;2.7.13.3;3.4.23.5;5.4.2.11;5.4.2.4;2.7.1.1;3.3.2.6;3.4.11.4;2.7.1.11;5.3.2.1;5.3.3.12;3.4.21.46;3.1.6.4;2.4.2.7;5.4.2.2;1.1.1.42;3.6.4.6;3.4.24.35;3.1.6.12;2.3.2.26;3.6.4.10;2.7.11.24;2.4.2.1;3.4.22.52;3.4.22.27;2.7.11.39;5.3.1.9;5.1.3.-;3.5.1.23;3.5.1.-;3.6.1.6;3.4.25.1;3.4.18.1;1.11.1.24", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003876 AMP deaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046033 AMP metabolic process;GO:0046032 ADP catabolic process;GO:0097009 energy homeostasis;GO:0006196 AMP catabolic process;GO:0006188 IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O09178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1M7Y5-1", "uniprot_id": "KPCI_RAT", "mass": 68276.0, "length": 596, "protein_name": "Protein kinase C iota type", "gene_name": "Prkci", "organism": "Rat", "refseq_name": "protein kinase C iota type", "refseq_ac": "NP_114448", "gene_names_uniprotkb": "Prkci; Pkcl", "gene_names_refseq": "Pkcl; Prkci", "protein_names_uniprotkb": "Protein kinase C iota type; 2.7.11.13; Atypical protein kinase C-lambda/iota; aPKC-lambda/iota; nPKC-iota", "protein_names_refseq": "aPKC-lambda/iota; atypical protein kinase C-lambda/iota; nPKC-iota; protein kinase C iota type; protein kinase C, lambda", "tax_id": 10116, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); ovarian carcinoma (Disease Ontology:DOID:4001); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:84006); (R-RNO-1912408); (R-RNO-209543); (R-RNO-420029); (R-RNO-9755511)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "11891849;19090727;22673903;23305840;23511975;27498875;28073831;28432079", "class_list": "", "function": "Acute inhibition of CNS aPKC activity increases food intake and glucose intolerance. Chronic inactivation of CNS aPKC activity increases body weight and food intake during high fat diet feeding., [RefSeq, PubMed]; Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI3K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Downstream of PI3K is required for insulin-stimulated glucose transport. Activates RAB4A and promotes its association with KIF3A which is required for the insulin-induced SLC2A4/GLUT4 translocation in adipocytes. Is essential in early embryogenesis and development of differentiating photoreceptors by playing a role in the establishment of epithelial and neuronal polarity (By similarity). Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (PubMed:27498875)., [UniProtKB, PubMed]; FGF21 inhibits hepatic glucose production by the PI3K-dependent activation of protein kinase c iota., [RefSeq, PubMed]; PKClambda is critical in AMPA receptor phosphorylation and synaptic incorporation during long-term potentiation., [RefSeq, PubMed]; PKMzeta, but not PKCiota, knock-down disrupted previously established long-time memory. PKCiota and PKMz have distinct functions in long-term potentiation and memory, with PKMzeta playing a specific role in memory maintenance., [RefSeq, PubMed]; Polarity signaling via CDC42/atypical protein kinase C can affect the dynamic turnover of the intermediate filament network to promote the polarization of the network itself., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1PZT8", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.3.2.27;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0035089 establishment of apical/basal cell polarity;GO:0006468 protein phosphorylation;GO:0007015 actin filament organization;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "F1M7Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09175-1", "uniprot_id": "AMPB_RAT", "mass": 72620.0, "length": 650, "protein_name": "Aminopeptidase B", "gene_name": "Rnpep", "organism": "Rat", "refseq_name": "aminopeptidase B isoform 1", "refseq_ac": "NP_112359", "gene_names_uniprotkb": "Rnpep", "gene_names_refseq": "Rnpep", "protein_names_uniprotkb": "Aminopeptidase B; 3.4.11.6; AP-B; Arginine aminopeptidase; Arginyl aminopeptidase; Cytosol aminopeptidase IV", "protein_names_refseq": "AP-B; aminopeptidase B isoform 1; aminopeptidase B; arginine aminopeptidase; cytosol aminopeptidase IV", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:81761)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10467730;21237246;8940051;9096329", "class_list": "", "function": "A structural analysis using circular dichroism, fluorescence spectroscopy, molecular modelling and dynamics was performed to investigate the role that residue G(298) plays in the catalytic mechanism of Ap-B, [RefSeq, PubMed]; Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97530", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0005507 copper ion binding;GO:0042277 peptide binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0045776 negative regulation of blood pressure;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O09175-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08619-1", "uniprot_id": "F13A_RAT", "mass": 82659.0, "length": 732, "protein_name": "Coagulation factor XIII A chain", "gene_name": "F13a1", "organism": "Rat", "refseq_name": "coagulation factor XIII A chain", "refseq_ac": "NP_067730", "gene_names_uniprotkb": "F13a1; F13a", "gene_names_refseq": "F13a1; F13a", "protein_names_uniprotkb": "Coagulation factor XIII A chain; 2.3.2.13; Coagulation factor XIIIa; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain", "protein_names_refseq": "coagulation factor XIII A chain; coagulation factor XIII, A1 polypeptide; coagulation factor XIII, A1 subunit; coagulation factor XIIIa; protein-glutamine gamma-glutamyltransferase A chain; transglutaminase A chain", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); gastric ulcer (Disease Ontology:DOID:10808); disseminated intravascular coagulation (Disease Ontology:DOID:11247); factor XIII deficiency (Disease Ontology:DOID:2211); arteriosclerosis (Disease Ontology:DOID:2349); myocardial infarction (Disease Ontology:DOID:5844); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); priapism (Disease Ontology:DOID:9286); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (rno:60327); (R-RNO-114608); (R-RNO-9769733)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.13;4.1.2.13;3.4.21.5;3.4.21.69;3.4.21.46;1.-.-.-;1.8.3.2;3.4.-.-;2.3.1.-;3.5.1.44", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0007596 blood coagulation;GO:0018149 peptide cross-linking;GO:0072378 blood coagulation, fibrin clot formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O08619-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89046-1", "uniprot_id": "COR1B_RAT", "mass": 53845.0, "length": 484, "protein_name": "Coronin-1B", "gene_name": "Coro1b", "organism": "Rat", "refseq_name": "coronin-1B", "refseq_ac": "NP_062095", "gene_names_uniprotkb": "Coro1b", "gene_names_refseq": "Coro1b", "protein_names_uniprotkb": "Coronin-1B; Coronin-2", "protein_names_refseq": "coronin, actin-binding protein, 1B; coronin-1B; coronin-2", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:29474)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16027158;17350576;17456547;22619279", "class_list": "", "function": "F-actin binding is absolutely required for coronin 1B to exert its effects on whole-cell motility and lamellipodial dynamics., [RefSeq, PubMed]; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study concludes that Coronin 1B's coordination of filament formation by Arp2/3 complex and filament turnover by Cofilin is required for effective lamellipodial protrusion and cell migration., [RefSeq, PubMed]; Suggest that phosphorylation of Coro1B and the subsequent reduced interaction with ARP2/3 complex participate in PDGF-induced VSMC migration, an important step in vascular lesion formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0044877 protein-containing complex binding;GO:0008092 cytoskeletal protein binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0035556 intracellular signal transduction;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O89046-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0R3K6-1", "uniprot_id": "F107A_RAT", "mass": 15930.0, "length": 131, "protein_name": "Actin-associated protein FAM107A", "gene_name": "Fam107a", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fam107a", "gene_names_refseq": "", "protein_names_uniprotkb": "Actin-associated protein FAM107A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:361018)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21969592", "class_list": "", "function": "Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005925 focal adhesion", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0050890 cognition;GO:1900272 negative regulation of long-term synaptic potentiation;GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0R3K6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35132-1", "uniprot_id": "CP27B_RAT", "mass": 55369.0, "length": 501, "protein_name": "25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial", "gene_name": "Cyp27b1", "organism": "Rat", "refseq_name": "25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial", "refseq_ac": "NP_446215", "gene_names_uniprotkb": "Cyp27b1; Cyp27b", "gene_names_refseq": "Cyp27b1; Cyp40", "protein_names_uniprotkb": "25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 1.14.15.18; 25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; Calcidiol 1-monooxygenase; Cytochrome P450 subfamily XXVIIB polypeptide 1; Cytochrome P450C1 alpha; Cytochrome P450VD1-alpha; Cytochrome p450 27B1; VD3 1A hydroxylase", "protein_names_refseq": "25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; P450C1 alpha; P450VD1-alpha; VD3 1A hydroxylase; calcidiol 1-monooxygenase; cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1; cytochrome P450 subfamily XXVIIB polypeptide 1; cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase); cytochrome P450, subfamily 27b, polypeptide 1; cytochrome P450C1 alpha; cytochrome P450VD1-alpha; cytochrome p450 27B1", "tax_id": 10116, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); vitamin D-dependent rickets type 1A (Disease Ontology:DOID:0080886); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); gestational diabetes (Disease Ontology:DOID:11714); alcohol use disorder (Disease Ontology:DOID:1574); hepatitis B (Disease Ontology:DOID:2043); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); Wilson disease (Disease Ontology:DOID:893); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:114700); (R-RNO-196791); (R-RNO-211916)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "9333115;9371776", "class_list": "", "function": "Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)(2)D3), and of 24,25-dihydroxyvitamin D3 (24,25(OH)(2)D3) to 1-alpha,24,25-trihydroxyvitamin D3 (1alpha,24,25(OH)(3)D3). Is also active with 25-hydroxy-24-oxo-vitamin D3. Plays an important role in normal bone growth, calcium metabolism, and tissue differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35076", "ec_number_list": "1.14.15.18", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004498 calcidiol 1-monooxygenase activity;GO:0062185 secalciferol 1-monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0042359 vitamin D metabolic process;GO:0042369 vitamin D catabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0051592 response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35132-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08590-1", "uniprot_id": "AOC3_RAT", "mass": 84981.0, "length": 763, "protein_name": "Amine oxidase [copper-containing] 3", "gene_name": "Aoc3", "organism": "Rat", "refseq_name": "amine oxidase [copper-containing] 3", "refseq_ac": "NP_113770", "gene_names_uniprotkb": "Aoc3", "gene_names_refseq": "Aoc3; SSAO", "protein_names_uniprotkb": "Amine oxidase [copper-containing] 3; 1.4.3.21; Amine oxidase copper-containing 3; Copper amine oxidase; SSAO; Semicarbazide-sensitive amine oxidase; VAP-1; VP97; Vascular adhesion protein 1", "protein_names_refseq": "VAP-1; VP97; amine oxidase [copper-containing] 3; copper amine oxidase; membrane primary amine oxidase; semicarbazide-sensitive amine oxidase; vascular adhesion protein 1", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); intracranial aneurysm (Disease Ontology:DOID:10941); uveitis (Disease Ontology:DOID:13141); aortic aneurysm (Disease Ontology:DOID:3627); congestive heart failure (Disease Ontology:DOID:6000); diabetic retinopathy (Disease Ontology:DOID:8947); cerebral amyloid angiopathy (Disease Ontology:DOID:9246); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29473); (R-RNO-211945)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15744061;28318627;28910971;29600311;32410850;36835077;8520629;9083076", "class_list": "", "function": "Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Has a preference for the primary monoamines methylamine and benzylamine (PubMed:15744061). Could also act on 2-phenylethylamine but much less efficiently. At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion (By similarity)., [UniProtKB, PubMed, UniProtKB]; Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that 35 potential amine oxidase copper containing 3 (SSAO)-interacting proteins were found to be altered in type 2 Diabetes (T2D)., [RefSeq, PubMed]; In acute mesenteric ischemia, Vap-1 levels are significantly increased and correlated with ischemic changes., [RefSeq, PubMed]; The Biological Implication of Semicarbazide-Sensitive Amine Oxidase (SSAO) Upregulation in Rat Systemic Inflammatory Response under Simulated Aerospace Environment. Publication Status: Online-Only, [RefSeq, PubMed]; VAP-1 plays a critical role in the pathophysiology of renal ischemia/reperfusion injury by enhancement of neutrophil infiltration generating a local hydrogen peroxide gradient., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q497D2;Q5R1T5", "ec_number_list": "1.4.3.21;1.4.3.4;1.4.3.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007155 cell adhesion;GO:0008217 regulation of blood pressure;GO:0042755 eating behavior;GO:0002523 leukocyte migration involved in inflammatory response;GO:0002675 positive regulation of acute inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O08590-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08726-1", "uniprot_id": "GALR2_RAT", "mass": 40676.0, "length": 372, "protein_name": "Galanin receptor type 2", "gene_name": "Galr2", "organism": "Rat", "refseq_name": "galanin receptor type 2", "refseq_ac": "NP_062045", "gene_names_uniprotkb": "Galr2; Galnr2", "gene_names_refseq": "GAL2-R; GALR-2; Galr2", "protein_names_uniprotkb": "Galanin receptor type 2; GAL2-R; GALR-2", "protein_names_refseq": "galanin receptor type 2", "tax_id": 10116, "disease": "", "pathway": " (rno:29234); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "28378856;29928003;33632048;38622072;9108306;9281594;9305929;9427506", "class_list": "", "function": "Activation of GalR2, probably through NPY or nitric oxide, induces c-Fos expression in the cuneate nucleus and transmits mechanical allodynia sensations to the thalamus. Publication Status: Online-Only, [RefSeq, PubMed]; Both the galanin and galanin receptor 2 mRNA expression and content increased significantly in anterior cingulate cortex (ACC) in rats with mononeuropathy than that in normal rats. Publication Status: Online-Only, [RefSeq, PubMed]; Effect of spexin on renal dysfunction in experimentally obese rats: potential mitigating mechanisms via galanin receptor-2., [RefSeq, PubMed]; Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder., [RefSeq, PubMed]; Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i))., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004966 galanin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0031175 neuron projection development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O08726-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09032-1", "uniprot_id": "ELAV4_RAT", "mass": 42368.0, "length": 385, "protein_name": "ELAV-like protein 4", "gene_name": "Elavl4", "organism": "Rat", "refseq_name": "ELAV-like protein 4", "refseq_ac": "NP_001071119", "gene_names_uniprotkb": "Elavl4; Hud", "gene_names_refseq": "Elavl4; HuD", "protein_names_uniprotkb": "ELAV-like protein 4; Hu-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD", "protein_names_refseq": "ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D); ELAV like neuron-specific RNA binding protein 4; ELAV-like protein 4; hu-antigen D; paraneoplastic encephalomyelitis antigen HuD", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); learning disability (Disease Ontology:DOID:8927)", "pathway": " (rno:432358)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10982410;11948657;12957493;15519747;16508003;16554442;17234598;17577668;21389246;22673903;25692578;25944900;26152301;28849006;28871047;31173231;8717365", "class_list": "", "function": "Both ZBP1 and HuD bind the zipcode element in rat beta-actin mRNA's 3' UTR. Differences between HuD and ZBP1 were observed in their binding preference to the element., [RefSeq, PubMed]; Downregulation of P2Y2 and HuD may partly be related to the development of the enteric nervous system in anorectal malformations embryos., [RefSeq, PubMed]; MTOR inhibition reduces HuD binding and promotes deadenylation of CaMKIIalpha mRNA., [RefSeq, PubMed]; RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10982410, PubMed:16508003, PubMed:17577668). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10982410, PubMed:16508003, PubMed:17577668). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10982410). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (By similarity). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (By similarity). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:10982410, PubMed:17577668). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (By similarity). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (PubMed:16508003). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (By similarity). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:10982410, PubMed:17234598). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (PubMed:10982410). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (PubMed:25692578). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (By similarity). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released form ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (By similarity). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich sequences of CALCA pre-mRNA (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; The HuD protein is abnormally expressed in the nerve plexuses of the intestinal wall of the terminal rectum of ARM embryonic rats, which suggests that HuD may participate in the development and maturation of the ENS in ARM embryonic rats., [RefSeq, PubMed]; The data indicate that endogenous Nrn1 and Gap43 mRNAs compete for binding to HuD for their axonal localization and activity of the Nrn1 3'UTR., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140TAF2", "ec_number_list": "", "go_molecular_function": "GO:0097158 pre-mRNA intronic pyrimidine-rich binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0031099 regeneration;GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0007399 nervous system development;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O09032-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35431-1", "uniprot_id": "APBA2_RAT", "mass": 82850.0, "length": 750, "protein_name": "Amyloid-beta A4 precursor protein-binding family A member 2", "gene_name": "Apba2", "organism": "Rat", "refseq_name": "amyloid-beta A4 precursor protein-binding family A member 2", "refseq_ac": "NP_113968", "gene_names_uniprotkb": "Apba2; Mint2", "gene_names_refseq": "Apba2; Mint2", "protein_names_uniprotkb": "Amyloid-beta A4 precursor protein-binding family A member 2; Adapter protein X11beta; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2", "protein_names_refseq": "adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); amyloid-beta A4 precursor protein-binding family A member 2; neuron-specific X11L protein; neuronal Munc18-1-interacting protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:83610)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18007179;19265194;20369384;9395480", "class_list": "", "function": "Mint2 is a novel TrkA-regulating protein that affects NGF-induced neurite outgrowth, possibly through a mechanism involving retention of TrkA in the Golgi apparatus., [RefSeq, PubMed]; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta., [UniProtKB]; These data suggest that Mint2 may play more important role in spinal cord than the other two family members., [RefSeq, PubMed]; Upon neurodegeneration with okadaic acid, mint-1 and mint-2 levels were reduced by proteolytic cleavage, and these changes were followed by increases in APP levels., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043197 dendritic spine", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007626 locomotory behavior;GO:0015031 protein transport;GO:0007268 chemical synaptic transmission;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35431-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35462-1", "uniprot_id": "ANGP2_RAT", "mass": 56518.0, "length": 496, "protein_name": "Angiopoietin-2", "gene_name": "Angpt2", "organism": "Rat", "refseq_name": "angiopoietin-2 precursor", "refseq_ac": "NP_604449", "gene_names_uniprotkb": "Angpt2; Agpt2", "gene_names_refseq": "Agpt2; Ang-2; Angpt2", "protein_names_uniprotkb": "Angiopoietin-2; ANG-2", "protein_names_refseq": "angiopoietin-2 precursor", "tax_id": 10116, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); Caroli disease (Disease Ontology:DOID:0050876); stroke (Disease Ontology:DOID:0051061); alcohol-associated liver disease (Disease Ontology:DOID:0070658); COVID-19 (Disease Ontology:DOID:0080600); portal hypertension (Disease Ontology:DOID:10762); gastric ulcer (Disease Ontology:DOID:10808); retinopathy of prematurity (Disease Ontology:DOID:13025); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); brain ischemia (Disease Ontology:DOID:2316); nephrosis (Disease Ontology:DOID:2527); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial adenocarcinoma (Disease Ontology:DOID:2870); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); adenocarcinoma (Disease Ontology:DOID:299); high grade glioma (Disease Ontology:DOID:3070); rhabdomyosarcoma (Disease Ontology:DOID:3247); ischemia (Disease Ontology:DOID:326); uremia (Disease Ontology:DOID:4676); vasculogenic impotence (Disease Ontology:DOID:4762); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); diabetic retinopathy (Disease Ontology:DOID:8947); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:89805); (R-RNO-210993)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "28637680;32720664;35289235;9776732", "class_list": "", "function": "Based on these findings, we propose that Cx43 was the Cx isoform involved in MEGJ-mediated VEC-dependent regulation of Ang-2, which induces iNOS protein expression and vascular hyporeactivity after hypoxia., [RefSeq, PubMed]; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (By similarity). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression (By similarity). In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). Involved in the regulation of lymphangiogenesis (By similarity)., [UniProtKB, UniProtKB]; Short-term angiotensin II treatment regulates cardiac nanomechanics via microtubule modifications., [RefSeq, PubMed]; SiRNA knockdown of angiopoietin 2 significantly reduces neovascularization in diabetic rats., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B1WBY0;Q548N5", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030971 receptor tyrosine kinase binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0042995 cell projection", "go_biological_process": "GO:0001525 angiogenesis;GO:0001666 response to hypoxia;GO:0007596 blood coagulation;GO:0045766 positive regulation of angiogenesis;GO:0009612 response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35462-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35552-1", "uniprot_id": "F263_RAT", "mass": 63676.0, "length": 555, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3", "gene_name": "Pfkfb3", "organism": "Rat", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 1", "refseq_ac": "NP_476476", "gene_names_uniprotkb": "Pfkfb3", "gene_names_refseq": "Pfkfb3", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ase brain-type isozyme; PFK/FBPase 3; RB2K", "protein_names_refseq": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 1; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme; 6PF-2-K/Fru-2,6-P2ase 3; PFK/FBPase 3; RB2K", "tax_id": 10116, "disease": "extrinsic cardiomyopathy (Disease Ontology:DOID:3978)", "pathway": " (rno:117276); (R-RNO-9634600)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "32841050;34016793;34490476;36916342;9202288", "class_list": "", "function": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and ''cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats., [RefSeq, PubMed]; Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB]; Kappa-opioid receptor stimulation alleviates rat vascular smooth muscle cell calcification via PFKFB3-lactate signaling., [RefSeq, PubMed]; Silencing of PFKFB3 protects podocytes against high glucoseinduced injury by inducing autophagy., [RefSeq, PubMed]; [Sleep deprivation aggravates cognitive impairment in septic rats by activating neuronal glycolytic isoenzyme PFKFB3]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35096;O35553;O35554;O35555;O35556;O35557;Q9QWQ5;Q9QWQ6", "ec_number_list": "3.1.3.46;2.7.1.105", "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0006915 apoptotic process;GO:0006094 gluconeogenesis;GO:0006000 fructose metabolic process;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35552-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35568-1", "uniprot_id": "FBLN3_RAT", "mass": 54596.0, "length": 493, "protein_name": "EGF-containing fibulin-like extracellular matrix protein 1", "gene_name": "Efemp1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Efemp1; Fbln3", "gene_names_refseq": "", "protein_names_uniprotkb": "EGF-containing fibulin-like extracellular matrix protein 1; FIBL-3; Fibulin-3; T16 protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "Doyne honeycomb retinal dystrophy (Disease Ontology:DOID:0060745); high grade glioma (Disease Ontology:DOID:3070); cutis laxa (Disease Ontology:DOID:3144); macular degeneration (Disease Ontology:DOID:4448); adenoma (Disease Ontology:DOID:657); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:305604)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18803302;9268694", "class_list": "", "function": "Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0005006 epidermal growth factor receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:1903975 regulation of glial cell migration;GO:0008284 positive regulation of cell population proliferation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0006355 regulation of DNA-templated transcription;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35568-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35780-1", "uniprot_id": "BHE40_RAT", "mass": 45529.0, "length": 411, "protein_name": "Class E basic helix-loop-helix protein 40", "gene_name": "Bhlhe40", "organism": "Rat", "refseq_name": "class E basic helix-loop-helix protein 40", "refseq_ac": "NP_445780", "gene_names_uniprotkb": "Bhlhe40; Bhlhb2; Sharp2", "gene_names_refseq": "Bhlhb2; Bhlhe40; Dec1; SHARP-2; Sharp2; Stra13; Stra14", "protein_names_uniprotkb": "Class E basic helix-loop-helix protein 40; Class B basic helix-loop-helix protein 2; Enhancer-of-split and hairy-related protein 2; SHARP-2; bHLHb2; bHLHe40", "protein_names_refseq": "basic helix-loop-helix domain containing, class B2; class B basic helix-loop-helix protein 2; class E basic helix-loop-helix protein 40; enhancer-of-split and hairy-related protein 2; stimulated by retinoic acid 14", "tax_id": 10116, "disease": "", "pathway": " (rno:79431)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12397359;12796501;22673903;27792527;29952285;36881362;9532582", "class_list": "", "function": "BHLHE40 is required for insulin induction of SREBP-1c mRNA in rodent liver. Publication Status: Online-Only, [RefSeq, PubMed]; Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family [dec1 & dec2], [RefSeq, PubMed]; Insulin induces the expression of the rat SHARP-2 gene at the transcription level via both a PI 3-K/aPKClambda- and a PI 3-K/mTOR- pathways, [RefSeq, PubMed]; Insulin induces the transcription of the rat SHARP-2 gene via a phosphoinositide 3-kinase pathway., [RefSeq, PubMed]; Protective effect of basic helix-loop-helix family member e40 on cerebral ischemia/reperfusion injury: Inhibition of apoptosis via repressing the transcription of pleckstrin homology-like domain family A, member 1., [RefSeq, PubMed]; This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (By similarity). Represses the transcription of NR0B2 and attenuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (By similarity). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0045892 negative regulation of DNA-templated transcription;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35780-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35817-1", "uniprot_id": "AKA14_RAT", "mass": 55756.0, "length": 502, "protein_name": "A-kinase anchor protein 14", "gene_name": "Akap14", "organism": "Rat", "refseq_name": "A-kinase anchor protein 14", "refseq_ac": "NP_067735", "gene_names_uniprotkb": "Akap14; Takap80", "gene_names_refseq": "Akap14", "protein_names_uniprotkb": "A-kinase anchor protein 14; AKAP-14; TAKAP-1.2; Testis-specific A-kinase-anchoring protein TAKAP-80", "protein_names_refseq": "A kinase (PRKA) anchor protein 14; A-kinase anchor protein 14; AKAP-14; TAKAP-1.2; Testis-specific A-kinase-anchoring-protein; testis-specific A-kinase-anchoring protein TAKAP-80", "tax_id": 10116, "disease": "", "pathway": " (rno:60332)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9208934", "class_list": "", "function": "Binds to type II regulatory subunits of protein kinase A and anchors/targets them., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034237 protein kinase A regulatory subunit binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005930 axoneme;GO:0005952 cAMP-dependent protein kinase complex;GO:0035686 sperm fibrous sheath", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35817-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35820-1", "uniprot_id": "DNPH1_RAT", "mass": 17781.0, "length": 163, "protein_name": "5-hydroxymethyl-dUMP N-hydrolase", "gene_name": "Dnph1", "organism": "Rat", "refseq_name": "5-hydroxymethyl-dUMP N-hydrolase", "refseq_ac": "NP_598209", "gene_names_uniprotkb": "Dnph1; Rcl", "gene_names_refseq": "C6orf108; Dnph1; RGD620382; Rcl", "protein_names_uniprotkb": "5-hydroxymethyl-dUMP N-hydrolase; 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; 3.2.2.-; Deoxyribonucleoside 5'-monophosphate N-glycosidase; c-Myc-responsive protein Rcl", "protein_names_refseq": "5-hydroxymethyl-dUMP N-hydrolase; Nucleoside 2-deoxyribosyltransferase domain containing protein RGD620382; c-Myc-responsive protein Rcl; deoxyribonucleoside 5'-monophosphate N-glycosidase; putative c-Myc-responsive", "tax_id": 10116, "disease": "", "pathway": " (rno:171047); (R-RNO-74259)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11991256;17234634;19720067;19822152;20962348;22673903;23385460;24260472;25108359;9271375", "class_list": "", "function": "Analysis of human deoxynucleotide N-hydrolase Rcl and rat gene c6orf108, [RefSeq, PubMed]; C6orf108 encodes a novel enzyme, deoxynucleoside 5'-monophosphate N-glycosidase, [RefSeq, PubMed]; Ligand-induced stabilization of the dimer structure of the enzyme, [RefSeq, PubMed]; Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration., [UniProtKB, UniProtKB]; RCL is a symmetric homodimer, with each monomer consisting of a five-stranded parallel beta-sheet sandwiched between five alpha-helices. Three of the helices form the dimer interface, allowing two monomers to pack side by side., [RefSeq, PubMed]; Rcl as an important antiapoptotic protein mediating sensitivity to Coptidis Rhizoma induction in cancer cells, [RefSeq, PubMed]; The crystal structure of oncoprotein Rcl bound to thymidine analogue 6-RADP-1-C6PA confirms and more precisely reveals the organization of its nucleotide-binding site., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.2.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0070694 5-hydroxymethyl-dUMP N-hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0030855 epithelial cell differentiation;GO:0000255 allantoin metabolic process;GO:0009159 deoxyribonucleoside monophosphate catabolic process;GO:0046055 dGMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35820-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35870-1", "uniprot_id": "FANCC_RAT", "mass": 63592.0, "length": 557, "protein_name": "Fanconi anemia group C protein homolog", "gene_name": "Fancc", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fancc; Facc", "gene_names_refseq": "", "protein_names_uniprotkb": "Fanconi anemia group C protein homolog; Protein FACC", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Fanconi anemia complementation group C (Disease Ontology:DOID:0111087); cholelithiasis (Disease Ontology:DOID:10211); prostate cancer (Disease Ontology:DOID:10283); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); pancytopenia (Disease Ontology:DOID:12450); Fanconi anemia (Disease Ontology:DOID:13636); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); gallbladder cancer (Disease Ontology:DOID:3121); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:24361); (R-RNO-6783310); (R-RNO-9833482)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9196001", "class_list": "", "function": "DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0007281 germ cell development;GO:0019430 removal of superoxide radicals;GO:0048854 brain morphogenesis;GO:0002262 myeloid cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35870-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55159-1", "uniprot_id": "EPCAM_RAT", "mass": 35207.0, "length": 315, "protein_name": "Epithelial cell adhesion molecule", "gene_name": "Epcam", "organism": "Rat", "refseq_name": "epithelial cell adhesion molecule precursor", "refseq_ac": "NP_612550", "gene_names_uniprotkb": "Epcam; Tacstd1", "gene_names_refseq": "Egp314; Epcam; Tacstd1", "protein_names_uniprotkb": "Epithelial cell adhesion molecule; EGP314; Ep-CAM; Epithelial glycoprotein 314; Protein D5.7A; Tumor-associated calcium signal transducer 1", "protein_names_refseq": "ep-CAM; epithelial cell adhesion molecule precursor; epithelial glycoprotein 314; tumor-associated calcium signal transducer 1", "tax_id": 10116, "disease": "congenital diarrhea 5 with tufting enteropathy (Disease Ontology:DOID:0060776); hereditary nonpolyposis colorectal cancer type 8 (Disease Ontology:DOID:0070270); middle cerebral artery infarction (Disease Ontology:DOID:3525); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:171577); (R-RNO-202733)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10327052;16054130;23098445;23390083;25367431", "class_list": "", "function": "Cld7 supports tumorigenic features of EpC by provoking EpC cleavage and thereby its cotranscription factor activity, [RefSeq, PubMed]; EpCAM overexpression is asociated with hepatic tumors., [RefSeq, PubMed]; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that, prior to implantation, EpCAM mediates intercellular adhesion in the uterine epithelium., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0098641 cadherin binding involved in cell-cell adhesion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O55159-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70595-1", "uniprot_id": "ABCB6_RAT", "mass": 93305.0, "length": 836, "protein_name": "ATP-binding cassette sub-family B member 6", "gene_name": "Abcb6", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family B member 6", "refseq_ac": "NP_542149", "gene_names_uniprotkb": "Abcb6; Umat", "gene_names_refseq": "Abcb6; MTABC3", "protein_names_uniprotkb": "ATP-binding cassette sub-family B member 6; 7.6.2.5; ABC-type heme transporter ABCB6; Ubiquitously-expressed mammalian ABC half transporter", "protein_names_refseq": "ABC-type heme transporter ABCB6; ATP-binding cassette sub-family B member 6, mitochondrial; ATP-binding cassette sub-family B member 6; ATP-binding cassette, sub-family B (MDR/TAP), member 6; ATP-binding cassette, subfamily B (MDR/TAP), member 6; mammalian mitochondrial ABC protein 3; ubiquitously-expressed mammalian ABC half transporter", "tax_id": 10116, "disease": "dyschromatosis universalis hereditaria (Disease Ontology:DOID:0060304)", "pathway": " (rno:140669); (R-RNO-1369007)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16390497;18160489;9705847", "class_list": "", "function": "ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (By similarity). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (By similarity). May play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (By similarity). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (By similarity). In addition may play a role in the transition metal homeostasis (PubMed:18160489)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.5;7.6.2.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015439 ABC-type heme transporter activity;GO:0015562 efflux transmembrane transporter activity;GO:0020037 heme binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005741 mitochondrial outer membrane;GO:0005768 endosome", "go_biological_process": "GO:1903232 melanosome assembly;GO:0006878 intracellular copper ion homeostasis;GO:0055085 transmembrane transport;GO:0007420 brain development;GO:0006779 porphyrin-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70595-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88422-1", "uniprot_id": "GALT5_RAT", "mass": 105120.0, "length": 930, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 5", "gene_name": "Galnt5", "organism": "Rat", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 5", "refseq_ac": "NP_113984", "gene_names_uniprotkb": "Galnt5", "gene_names_refseq": "Galnt5", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 5; 2.4.1.41; GalNAc-T5; Polypeptide GalNAc transferase 5; Protein-UDP acetylgalactosaminyltransferase 5; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5; pp-GaNTase 5", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T5; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5); galNAc-T5; polypeptide GalNAc transferase 5; polypeptide N-acetylgalactosaminyltransferase 5; pp-GaNTase 5; protein-UDP acetylgalactosaminyltransferase 5", "tax_id": 10116, "disease": "", "pathway": " (rno:83627); (R-RNO-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9765313", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2, Muc1b, rMuc-2 or mG-Muc substrates., [UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 7434, "hit_score": 0.2, "record_id": "O88422-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89039-1", "uniprot_id": "ACKR3_RAT", "mass": 41650.0, "length": 362, "protein_name": "Atypical chemokine receptor 3", "gene_name": "Ackr3", "organism": "Rat", "refseq_name": "atypical chemokine receptor 3", "refseq_ac": "NP_445804", "gene_names_uniprotkb": "Ackr3; Cmkor1; Cxcr7; Rdc1", "gene_names_refseq": "Ackr3; Cmkor1; Cxcr7; Rdc1", "protein_names_uniprotkb": "Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G protein-coupled receptor RDC1 homolog; RDC-1", "protein_names_refseq": "C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; G-protein coupled receptor RDC1 homolog; RDC-1; atypical chemokine receptor 3; chemokine (C-X-C motif) receptor 7; chemokine orphan receptor 1", "tax_id": 10116, "disease": "laryngeal carcinoma (Disease Ontology:DOID:2600); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (rno:84348); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "18513805;18615560;20018651;21655198;22673903;30551373;33941256;34051857;36523152;37945645", "class_list": "", "function": "Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development., [UniProtKB, PubMed, UniProtKB]; CXCR7 mRNA was identified in the ventricle walls as well as neuronal, astroglial, and vascular cells. After ischemia, intact cortical regions showed a rapid, 4 days-lasting increase in neuronal CXCR7 expression., [RefSeq, PubMed]; CXCR7-overexpressing MSCs may markedly facilitate treatment of phosgene-induced ALI (P-ALI) in rats., [RefSeq, PubMed]; Chemokine receptor 7 mediates miRNA-182 to regulate cerebral ischemia/reperfusion injury in rats., [RefSeq, PubMed]; Gain of CXCR7 function with mesenchymal stem cell therapy ameliorates experimental arthritis via enhancing tissue regeneration and immunomodulation. Publication Status: Online-Only, [RefSeq, PubMed]; Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that CXCR4 and CXCR7 may cooperate or act independently in SDF-1-dependent neuronal development., [RefSeq, PubMed]; Upregulating CXCR7 accelerates endothelial progenitor cell-mediated endothelial repair by activating Akt/Keap-1/Nrf2 signaling in diabetes mellitus. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLZ0", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0015026 coreceptor activity;GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0009986 cell surface", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O89039-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00185-1", "uniprot_id": "CP1A1_RAT", "mass": 59393.0, "length": 524, "protein_name": "Cytochrome P450 1A1", "gene_name": "Cyp1a1", "organism": "Rat", "refseq_name": "cytochrome P450 1A1 isoform X1", "refseq_ac": "XP_006243212", "gene_names_uniprotkb": "Cyp1a1; Cyp1a-1", "gene_names_refseq": "AHH; AHRR; CP11; CYP1; Cyp1a1; Cyp45c; Cypc45c; P-450MC; P1-450; P450-C; P450DX", "protein_names_uniprotkb": "Cytochrome P450 1A1; 1.14.14.1; 4.2.1.152; CYP1A1; CYPIA1; Cytochrome P450 form 6; Cytochrome P450-C; Cytochrome P450-P1; Cytochrome P450MT2; Hydroperoxy icosatetraenoate dehydratase", "protein_names_refseq": "cytochrome P450 1A1 isoform X1", "tax_id": 10116, "disease": "Keshan disease (Disease Ontology:DOID:0050083); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); polycystic ovary syndrome (Disease Ontology:DOID:11612); clubfoot (Disease Ontology:DOID:11836); head and neck cancer (Disease Ontology:DOID:11934); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Graves' disease (Disease Ontology:DOID:12361); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); porphyria cutanea tarda (Disease Ontology:DOID:3132); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); biliary tract cancer (Disease Ontology:DOID:4607); esophageal cancer (Disease Ontology:DOID:5041); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); bronchitis (Disease Ontology:DOID:6132); reactive arthritis (Disease Ontology:DOID:6196); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); chronic myeloid leukemia (Disease Ontology:DOID:8552); oral cavity cancer (Disease Ontology:DOID:8618); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:24296); (R-RNO-211981); (R-RNO-2142670); (R-RNO-2142816); (R-RNO-9018681)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "19401463;20972997;24098488;3041969;3718958;3838427;6089174;6324135;8651689;9348277", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions (By similarity). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (By similarity). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (By similarity). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (By similarity). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 47, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;5.4.4.7;1.14.13.n7;1.14.14.94;5.3.99.5;1.14.14.80;5.3.99.4", "go_molecular_function": "GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002933 lipid hydroxylation;GO:0008210 estrogen metabolic process;GO:0042359 vitamin D metabolic process;GO:0046209 nitric oxide metabolic process;GO:1904010 response to Aroclor 1254", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P00185-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01015-1", "uniprot_id": "ANGT_RAT", "mass": 51982.0, "length": 477, "protein_name": "Angiotensinogen", "gene_name": "Agt", "organism": "Rat", "refseq_name": "angiotensinogen precursor", "refseq_ac": "NP_602308", "gene_names_uniprotkb": "Agt; Serpina8", "gene_names_refseq": "ANRT; Agt; AngII; Ang; PAT", "protein_names_uniprotkb": "Angiotensinogen; Ang III; Ang II; Ang IV; Ang I; Angiotensin 1-10; Angiotensin 1-8; Angiotensin 2-8; Angiotensin 3-8; Angiotensin III; Angiotensin II; Angiotensin IV; Angiotensin I; Des-Asp[1]-angiotensin II; Serpin A8", "protein_names_refseq": "angiotensin II; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); angiotensinogen precursor; serpin A8", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); polycystic kidney disease (Disease Ontology:DOID:0080322); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); meconium aspiration syndrome (Disease Ontology:DOID:11049); hydronephrosis (Disease Ontology:DOID:11111); IgA vasculitis (Disease Ontology:DOID:11123); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); prediabetes syndrome (Disease Ontology:DOID:11716); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); sick sinus syndrome (Disease Ontology:DOID:13884); Fabry disease (Disease Ontology:DOID:14499); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); glomerulonephritis (Disease Ontology:DOID:2921); temporal lobe epilepsy (Disease Ontology:DOID:3328); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); cerebrovascular disease (Disease Ontology:DOID:6713); chronic myeloid leukemia (Disease Ontology:DOID:8552); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24179); (R-RNO-2022377); (R-RNO-375276); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "18026570;20927107;21454685;36834901;37667574;38583954;38781757;39199363;4344907;6330095;6572971;9508787", "class_list": "", "function": "Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Angiotensin II Alters Mitochondrial Membrane Potential and Lipid Metabolism in Rat Colonic Epithelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Angiotensin II Is Involved in MLKL Activation During the Development of Heart Failure Following Myocardial Infarction in Rats., [RefSeq, PubMed]; Anti-Fibrotic Potential of Angiotensin (1-7) in Hemodynamically Overloaded Rat Heart. Publication Status: Online-Only, [RefSeq, PubMed]; Combining experiments and bioinformatics to identify transforming growth factor-beta1 as a key regulator in angiotensin II-induced trophoblast senescence., [RefSeq, PubMed]; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Fasting increases circulating angiotensin levels and brain Agtr1a expression in male rats., [RefSeq, PubMed]; Is a ligand for the G protein-coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (PubMed:18026570)., [UniProtKB, PubMed, UniProtKB]; Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets., [UniProtKB, UniProtKB, UniProtKB]; Stimulates aldosterone release., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 52, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0017080 sodium channel regulator activity;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0031702 type 1 angiotensin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0030432 peristalsis;GO:0035106 operant conditioning;GO:0001543 ovarian follicle rupture;GO:0010701 positive regulation of norepinephrine secretion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P01015-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01041-1", "uniprot_id": "CYTB_RAT", "mass": 11196.0, "length": 98, "protein_name": "Cystatin-B", "gene_name": "Cstb", "organism": "Rat", "refseq_name": "cystatin-B", "refseq_ac": "NP_036970", "gene_names_uniprotkb": "Cstb; Cst6", "gene_names_refseq": "Cstb; Cyb; Epm1; Stfb", "protein_names_uniprotkb": "Cystatin-B; Cystatin-beta; Liver thiol proteinase inhibitor; Stefin-B", "protein_names_refseq": "cystatin B (stefin B); cystatin beta; cystatin-B; liver thiol proteinase inhibitor; stefin-B", "tax_id": 10116, "disease": "progressive myoclonus epilepsy 1A (Disease Ontology:DOID:0111452); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); Unverricht-Lundborg syndrome (Disease Ontology:DOID:3535)", "pathway": " (rno:25308); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1601307;2251135;24063889;24234043;30052474;6626228", "class_list": "", "function": "A reciprocal influence of CSTB and SOD1 at the gene expression level and for a direct interaction of the two proteins, is reported., [RefSeq, PubMed]; Cu(2+) modifies the redox environment of the protein, allowing the oxidation of the cysteine residue of CSTB that triggers polymerization., [RefSeq, PubMed]; In contrast to the weak levels of cathepsin L in normal glomeruli, on days 4 and 8, strong immunostaining was detected in almost all podocytes when proteinuria and pathological changes of the podocytes developed. Cathepsin L was reduced after day 28, but remained in a focal and segmental manner. Cystatin B, an intracellular inhibitor, was not detected in podocytes., [RefSeq, PubMed]; This is an intracellular thiol proteinase inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004866 endopeptidase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:1990000 amyloid fibril formation;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01041-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01194-1", "uniprot_id": "COLI_RAT", "mass": 26540.0, "length": 235, "protein_name": "Pro-opiomelanocortin", "gene_name": "Pomc", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pomc; Pomc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Pro-opiomelanocortin; ACTH; Adrenocorticotropic hormone; Beta-LPH; Corticotropin-lipotropin; Gamma-LPH; Gamma-MSH; Melanotropin alpha; Melanotropin beta; POMC", "protein_names_refseq": "", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); Wernicke-Korsakoff syndrome (Disease Ontology:DOID:10915); hyperandrogenism (Disease Ontology:DOID:11613); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); severe acute respiratory syndrome (Disease Ontology:DOID:2945); familial Mediterranean fever (Disease Ontology:DOID:2987); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24664); (R-RNO-111885); (R-RNO-193048); (R-RNO-194002); (R-RNO-202040); (R-RNO-209952); (R-RNO-211976); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "2432275;2998878;6255341;6547437;7259753", "class_list": "", "function": "Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes., [UniProtKB]; Endogenous opiate., [UniProtKB, UniProtKB, UniProtKB]; Endogenous orexigenic opiate., [UniProtKB, UniProtKB, UniProtKB]; Increases the pigmentation of skin by increasing melanin production in melanocytes., [UniProtKB]; Precursor protein of pituitary hormones that are involved in diverse physiological processes, including the regulation of energy balance, stress response, immune function and skin pigmentation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Stimulates the adrenal glands to release cortisol., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity;GO:0031781 type 3 melanocortin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005782 peroxisomal matrix;GO:0030141 secretory granule", "go_biological_process": "GO:0043400 cortisol secretion;GO:1903999 negative regulation of eating behavior;GO:0005981 regulation of glycogen catabolic process;GO:0006091 generation of precursor metabolites and energy;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P01194-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02523-1", "uniprot_id": "CRBB1_RAT", "mass": 28093.0, "length": 250, "protein_name": "Beta-crystallin B1", "gene_name": "Crybb1", "organism": "Rat", "refseq_name": "beta-crystallin B1", "refseq_ac": "NP_037068", "gene_names_uniprotkb": "Crybb1", "gene_names_refseq": "CRYB11; CRYB1; Crybb1", "protein_names_uniprotkb": "Beta-crystallin B1; Beta-B1 crystallin", "protein_names_refseq": "beta-B1 crystallin; beta-crystallin B1", "tax_id": 10116, "disease": "cataract 17 multiple types (Disease Ontology:DOID:0110270); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:25421)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11773034;3458246;3879970;8405363", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JN26;Q9JHV9", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02523-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LQB7-1", "uniprot_id": "F1LQB7_RAT", "mass": 10271.0, "length": 95, "protein_name": "Defensin NP-4 precursor", "gene_name": "Defa7", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Defa7", "gene_names_refseq": "", "protein_names_uniprotkb": "Defensin NP-4 precursor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism;GO:0050832 defense response to fungus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LQB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3V6Q3-1", "uniprot_id": "G3V6Q3_RAT", "mass": 53883.0, "length": 485, "protein_name": "WD repeat-containing protein 13", "gene_name": "Wdr13", "organism": "Rat", "refseq_name": "WD repeat-containing protein 13 isoform X1", "refseq_ac": "XP_038955697", "gene_names_uniprotkb": "Wdr13", "gene_names_refseq": "RGD1560982; Wdr13", "protein_names_uniprotkb": "WD repeat-containing protein 13", "protein_names_refseq": "WD repeat-containing protein 13 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:317370)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:1904691 negative regulation of type B pancreatic cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1KMU0-1", "uniprot_id": "Q1KMU0_RAT", "mass": 45203.0, "length": 416, "protein_name": "TNF receptor superfamily member 19", "gene_name": "Tnfrsf19", "organism": "Rat", "refseq_name": "tumor necrosis factor receptor superfamily member 19 precursor", "refseq_ac": "NP_001037694", "gene_names_uniprotkb": "Tnfrsf19", "gene_names_refseq": "RGD1564996; Tnfrsf19", "protein_names_uniprotkb": "TNF receptor superfamily member 19", "protein_names_refseq": "tumor necrosis factor receptor superfamily member 19 precursor; tumor necrosis factor receptor superfamily, member 19", "tax_id": 10116, "disease": "", "pathway": " (rno:290300)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24129566", "class_list": "", "function": "The association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZUJ0", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0001942 hair follicle development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1KMU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06759-1", "uniprot_id": "APOC3_RAT", "mass": 11117.0, "length": 101, "protein_name": "Apolipoprotein C-III", "gene_name": "Apoc3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Apoc3", "gene_names_refseq": "", "protein_names_uniprotkb": "Apolipoprotein C-III; Apo-CIII; ApoC-III; Apolipoprotein C3", "protein_names_refseq": "", "tax_id": 10116, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); apolipoprotein C-III deficiency (Disease Ontology:DOID:0111370); glucose intolerance (Disease Ontology:DOID:10603); open-angle glaucoma (Disease Ontology:DOID:1067); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); nephrotic syndrome (Disease Ontology:DOID:1184); cholestasis (Disease Ontology:DOID:13580); familial combined hyperlipidemia (Disease Ontology:DOID:13809); hypothyroidism (Disease Ontology:DOID:1459); cognitive disorder (Disease Ontology:DOID:1561); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); renal artery obstruction (Disease Ontology:DOID:2972); hyperlipoproteinemia type III (Disease Ontology:DOID:3145); coronary artery disease (Disease Ontology:DOID:3393); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-8963888); (R-RNO-8963901); (R-RNO-8964058); (R-RNO-975634)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "3020028", "class_list": "", "function": "Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005543 phospholipid binding;GO:0055102 lipase inhibitor activity;GO:0070653 high-density lipoprotein particle receptor binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0034363 intermediate-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0034366 spherical high-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0006869 lipid transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007584 response to nutrient;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P06759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q498R7-1", "uniprot_id": "CZIB_RAT", "mass": 18095.0, "length": 160, "protein_name": "CXXC motif containing zinc binding protein", "gene_name": "Czib", "organism": "Rat", "refseq_name": "CXXC motif containing zinc binding protein", "refseq_ac": "NP_001029304", "gene_names_uniprotkb": "Czib", "gene_names_refseq": "Czib; RGD1559786", "protein_names_uniprotkb": "CXXC motif containing zinc binding protein; UPF0587 protein C1orf123 homolog", "protein_names_refseq": "CXXC motif containing zinc binding protein; UPF0587 protein C1orf123 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:298384)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q498R7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8I1-1", "uniprot_id": "EPCR_RAT", "mass": 26839.0, "length": 241, "protein_name": "Endothelial protein C receptor", "gene_name": "Procr", "organism": "Rat", "refseq_name": "endothelial protein C receptor precursor", "refseq_ac": "NP_001020904", "gene_names_uniprotkb": "Procr", "gene_names_refseq": "EPCR; Procr", "protein_names_uniprotkb": "Endothelial protein C receptor; APC receptor; Activated protein C receptor; Endothelial cell protein C receptor", "protein_names_refseq": "APC receptor; activated protein C receptor; endothelial cell protein C receptor; endothelial protein C receptor precursor; endothelial protein C receptor; protein C receptor, endothelial", "tax_id": 10116, "disease": "malaria (Disease Ontology:DOID:12365); carotid stenosis (Disease Ontology:DOID:13001); acute kidney failure (Disease Ontology:DOID:3021)", "pathway": " (rno:362248); (R-RNO-202733); (R-RNO-9769739)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19680809", "class_list": "", "function": "Activated protein C could augment the anti-coagulation and anti-inflammatory activity by up-regulating endothelial cell protein C receptor and thrombomodulin expression, thus attenuating the severity of severe acute pancreatis., [RefSeq, PubMed]; Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005813 centrosome;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007596 blood coagulation;GO:0050819 negative regulation of coagulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8I1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QE78-1", "uniprot_id": "AOXB_RAT", "mass": 147872.0, "length": 1345, "protein_name": "Aldehyde oxidase 2", "gene_name": "Aox2", "organism": "Rat", "refseq_name": "aldehyde oxidase 2", "refseq_ac": "NP_001008522", "gene_names_uniprotkb": "Aox2; Aoh3; Aox3l1", "gene_names_refseq": "Aox2p; Aox2; Aox3l1", "protein_names_uniprotkb": "Aldehyde oxidase 2; 1.17.3.-; 1.2.3.1; Aldehyde oxidase homolog 3; Azaheterocycle hydroxylase 2", "protein_names_refseq": "aldehyde oxidase 2 pseudogene; aldehyde oxidase 2; aldehyde oxidase 3-like 1; aldehyde oxidase homolog 3; azaheterocycle hydroxylase 2", "tax_id": 10116, "disease": "xanthinuria (Disease Ontology:DOID:0060236)", "pathway": " (rno:316421)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15383531;23263164", "class_list": "", "function": "Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal., [UniProtKB, UniProtKB]; Selectively expressed in Bowman's glands of the olfactory mucosa., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D4A6S5", "ec_number_list": "1.17.3.-;1.2.3.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0004031 aldehyde oxidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5QE78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PPG7-1", "uniprot_id": "EIF2D_RAT", "mass": 62669.0, "length": 570, "protein_name": "Eukaryotic translation initiation factor 2D", "gene_name": "Eif2d", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 2D", "refseq_ac": "NP_001017489", "gene_names_uniprotkb": "Eif2d; Lgtn", "gene_names_refseq": "Eif2d; Lgtn", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2D; Ligatin; eIF2d", "protein_names_refseq": "eukaryotic translation initiation factor 2D; ligatin", "tax_id": 10116, "disease": "", "pathway": " (rno:498225)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0075522 IRES-dependent viral translational initiation;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PPG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31210-1", "uniprot_id": "AK1D1_RAT", "mass": 37378.0, "length": 326, "protein_name": "Aldo-keto reductase family 1 member D1", "gene_name": "Akr1d1", "organism": "Rat", "refseq_name": "aldo-keto reductase family 1 member D1", "refseq_ac": "NP_620239", "gene_names_uniprotkb": "Akr1d1", "gene_names_refseq": "Akr1d1", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member D1; 1.3.1.3; 3-oxo-5-beta-steroid 4-dehydrogenase; Delta(4)-3-ketosteroid 5-beta-reductase; Delta(4)-3-oxosteroid 5-beta-reductase", "protein_names_refseq": "3-oxo-5-beta-steroid 4-dehydrogenase; aldo-keto reductase family 1 member D1; aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase); delta(4)-3-ketosteroid 5-beta-reductase; delta(4)-3-oxosteroid 5-beta-reductase", "tax_id": 10116, "disease": "congenital bile acid synthesis defect 2 (Disease Ontology:DOID:0111069)", "pathway": " (rno:192242); (R-RNO-193368); (R-RNO-193775); (R-RNO-193807)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "1710579;1789929;8550030", "class_list": "", "function": "Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.270;1.1.1.62;1.1.1.64;1.3.1.3", "go_molecular_function": "GO:0016229 steroid dehydrogenase activity;GO:0004032 aldose reductase (NADPH) activity;GO:0047787 Delta4-3-oxosteroid 5beta-reductase activity;GO:0047086 ketosteroid monooxygenase activity;GO:0047568 3-oxo-5-beta-steroid 4-dehydrogenase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0007586 digestion;GO:0006707 cholesterol catabolic process;GO:0008207 C21-steroid hormone metabolic process;GO:0008209 androgen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P31210-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54759-1", "uniprot_id": "EPHA7_RAT", "mass": 111953.0, "length": 998, "protein_name": "Ephrin type-A receptor 7", "gene_name": "Epha7", "organism": "Rat", "refseq_name": "ephrin type-A receptor 7 precursor", "refseq_ac": "NP_599158", "gene_names_uniprotkb": "Epha7; Ehk-3; Ehk3", "gene_names_refseq": "EHK-3; Epha7", "protein_names_uniprotkb": "Ephrin type-A receptor 7; 2.7.10.1; EHK-3; EPH homology kinase 3", "protein_names_refseq": "EPH homology kinase 3; ephrin receptor EphA7; ephrin type-A receptor 7 precursor; ephrin type-A receptor 7; tyrosine-protein kinase receptor EHK-3", "tax_id": 10116, "disease": "", "pathway": " (rno:171287); (R-RNO-2682334); (R-RNO-3928663); (R-RNO-3928665)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "16983667;26780036;27405707;30292674;32396496;7731712", "class_list": "", "function": "EPHA7 is a positive upstream factor of C/EBPbeta contributing to the transcription and translation of KLF4, promoting ovulation via ADAMTS1. We demonstrated the functional role of EPHA7 in PCOS, which explains how the loss of EPHA7 underlies the ovulatory dysfunction., [RefSeq, PubMed]; EphA7 regulates gephyrin clustering and the maintenance of inhibitory synaptic connectivity via mTOR signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Erythropoietin-producing hepatocellular receptor A7 restrains estrogen negative feedback of luteinizing hormone via ephrin A5 in the hypothalamus of female rats., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7., [UniProtKB, PubMed]; The cell surface localization of EphA7 was preferentially in postsynaptic dendrites in the hippocampus and cerebellum., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.10.2;2.7.12.2;2.7.1.40;2.7.11.1;2.7.11.13;2.7.10.4;3.6.5.2;2.7.1.32;2.7.1.82;2.7.11.23", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046875 ephrin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body", "go_biological_process": "GO:0048755 branching morphogenesis of a nerve;GO:0043065 positive regulation of apoptotic process;GO:0048013 ephrin receptor signaling pathway;GO:0006915 apoptotic process;GO:0022407 regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P54759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q566C8-1", "uniprot_id": "ANR54_RAT", "mass": 32492.0, "length": 299, "protein_name": "Ankyrin repeat domain-containing protein 54", "gene_name": "Ankrd54", "organism": "Rat", "refseq_name": "ankyrin repeat domain-containing protein 54", "refseq_ac": "NP_001020456", "gene_names_uniprotkb": "Ankrd54", "gene_names_refseq": "Ankrd54; RGD1309552", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 54", "protein_names_refseq": "ankyrin repeat domain-containing protein 54", "tax_id": 10116, "disease": "", "pathway": " (rno:362957)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030496 midbody", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0045648 positive regulation of erythrocyte differentiation;GO:1902531 regulation of intracellular signal transduction;GO:0045859 regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q566C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50123-1", "uniprot_id": "AMPE_RAT", "mass": 107995.0, "length": 945, "protein_name": "Glutamyl aminopeptidase", "gene_name": "Enpep", "organism": "Rat", "refseq_name": "glutamyl aminopeptidase", "refseq_ac": "NP_071587", "gene_names_uniprotkb": "Enpep", "gene_names_refseq": "Enpep", "protein_names_uniprotkb": "Glutamyl aminopeptidase; 3.4.11.7; AP-A; Aminopeptidase A; EAP", "protein_names_refseq": "AP-A; EAP; aminopeptidase A; glutamyl aminopeptidase", "tax_id": 10116, "disease": "", "pathway": " (rno:64017); (R-RNO-2022377)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10666143;10978538;25960007;33161775;7943354;8613196", "class_list": "", "function": "A discrepancy between the high expression of AP-A in kidney of hyperthyroid rats and the low activity of AP-A measured in plasma and kidney of hyperthyroid animals was found., [RefSeq, PubMed]; Chromosome 2 Fragment Substitutions in Dahl Salt-Sensitive Rats and RNA Sequencing Identified Enpep and Hs2st1 as Vascular Inflammatory Modulators., [RefSeq, PubMed]; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q64200;Q9JLQ7;Q9JLQ9;Q9QV24", "ec_number_list": "3.4.11.7;3.4.11.-", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0042277 peptide binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0045177 apical part of cell;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0016485 protein processing;GO:0002003 angiotensin maturation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P50123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49911-1", "uniprot_id": "AN32A_RAT", "mass": 28565.0, "length": 247, "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "gene_name": "Anp32a", "organism": "Rat", "refseq_name": "acidic leucine-rich nuclear phosphoprotein 32 family member A", "refseq_ac": "NP_037035", "gene_names_uniprotkb": "Anp32a; Lanp", "gene_names_refseq": "Anp32a; Anp32; LANP", "protein_names_uniprotkb": "Acidic leucine-rich nuclear phosphoprotein 32 family member A; LANP; Leucine-rich acidic nuclear protein", "protein_names_refseq": "Acid nuclear phosphoprotein 32 (leucine rich); acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic leucine-rich nuclear phosphoprotein 32 family member A; leucine-rich acidic nuclear protein LANP", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:25379); (R-RNO-450520)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15865439;15895553;19136565;20617464;7937870", "class_list": "", "function": "LANP directly regulates expression of the neurofilament light chain, an important neuron-specific cytoskeletal gene, by binding to the promoter of this gene and modulating histone acetylation levels, [RefSeq, PubMed]; LANP interacts directly with the cytosolic domains of rat brain neural cell adhesion molecule (NCAM) 140 and 180 isoforms., [RefSeq, PubMed]; Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltransferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A., [UniProtKB, UniProtKB]; Multifunctional protein that is involved in the regulation of many processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These findings suggest that Lanp can interact with Rb in both young and mature neurons and is implicated in the regulation of neuronal survival by CXCL12/CXCR4, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0050839 cell adhesion molecule binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0042981 regulation of apoptotic process;GO:0031400 negative regulation of protein modification process;GO:0120033 negative regulation of plasma membrane bounded cell projection assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P49911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QR87-1", "uniprot_id": "DMRTC_RAT", "mass": 23842.0, "length": 225, "protein_name": "Doublesex- and mab-3-related transcription factor C1", "gene_name": "AABR07039229.2; Dmrtc1a; Dmrtc1", "organism": "Rat", "refseq_name": "doublesex- and mab-3-related transcription factor C1", "refseq_ac": "NP_001020459", "gene_names_uniprotkb": "AABR07039229.2; Dmrtc1a; Dmrtc1; AABR07039229.2; Dmrtc1a", "gene_names_refseq": "Dmrtc1a; Dmrtc1", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor C1", "protein_names_refseq": "DMRT like family C1; doublesex- and mab-3-related transcription factor C1", "tax_id": 10116, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (rno:108348153)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QR87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q569B9-1", "uniprot_id": "MFI_RAT", "mass": 36199.0, "length": 305, "protein_name": "Protein MFI", "gene_name": "C8h11orf65; Mfi", "organism": "Rat", "refseq_name": "protein MFI", "refseq_ac": "NP_001019436", "gene_names_uniprotkb": "C8h11orf65; Mfi; RGD1311251", "gene_names_refseq": "C8h11orf65; Mfi; RGD1311251", "protein_names_uniprotkb": "Protein MFI; Mitochondrial fission factor interactor; Protein C11orf65 homolog", "protein_names_refseq": "mitochondrial fission factor interactor; protein MFI; uncharacterized protein C11orf65 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:315665)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:1903215 negative regulation of protein targeting to mitochondrion;GO:0090258 negative regulation of mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q569B9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53610-1", "uniprot_id": "PGTB1_RAT", "mass": 42414.0, "length": 377, "protein_name": "Geranylgeranyl transferase type-1 subunit beta", "gene_name": "Pggt1b", "organism": "Rat", "refseq_name": "geranylgeranyl transferase type-1 subunit beta", "refseq_ac": "NP_112344", "gene_names_uniprotkb": "Pggt1b", "gene_names_refseq": "Pggt1b", "protein_names_uniprotkb": "Geranylgeranyl transferase type-1 subunit beta; 2.5.1.59; GGTase-I-beta; Geranylgeranyl transferase type I subunit beta; Type I protein geranyl-geranyltransferase subunit beta", "protein_names_refseq": "GGTase-I-beta; geranylgeranyl transferase type I subunit beta; geranylgeranyl transferase type-1 subunit beta; geranylgeranyltransferase type 1 beta; geranylgeranyltransferase type I (GGTase-I); protein geranylgeranyltransferase type 1 subunit beta; protein geranylgeranyltransferase type I, beta subunit; type I protein geranyl-geranyltransferase subunit beta", "tax_id": 10116, "disease": "", "pathway": " (rno:81746); (R-RNO-9953170)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14609943;15248757;15451670;20540740;8106351", "class_list": "", "function": "Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of proteins with the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B., [UniProtKB, PubMed]; Results indicate that geranylgeranyltransferase I (GGT) plays an important role in Purkinje cell development, and suggest a novel role of GGT in neuronal morphogenesis in vivo. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.59;2.5.1.58;2.5.1.60;3.6.5.-", "go_molecular_function": "GO:0004661 protein geranylgeranyltransferase activity;GO:0004662 CAAX-protein geranylgeranyltransferase activity;GO:0008270 zinc ion binding;GO:1901363 heterocyclic compound binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005953 CAAX-protein geranylgeranyltransferase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045787 positive regulation of cell cycle;GO:0018344 protein geranylgeranylation;GO:0080120 CAAX-box protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P53610-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVF9-1", "uniprot_id": "BTD_RAT", "mass": 58021.0, "length": 521, "protein_name": "Biotinidase", "gene_name": "Btd", "organism": "Rat", "refseq_name": "biotinidase isoform 2 precursor", "refseq_ac": "NP_001012047", "gene_names_uniprotkb": "Btd", "gene_names_refseq": "Btd", "protein_names_uniprotkb": "Biotinidase; 3.5.1.12; Biotinase", "protein_names_refseq": "biotinase; biotinidase isoform 2 precursor", "tax_id": 10116, "disease": "biotinidase deficiency (Disease Ontology:DOID:856)", "pathway": " (rno:306262); (R-RNO-196780)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.12", "go_molecular_function": "GO:0047708 biotinidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005730 nucleolus;GO:0043204 perikaryon;GO:0045177 apical part of cell", "go_biological_process": "GO:0006768 biotin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8C5-1", "uniprot_id": "AR2BP_RAT", "mass": 18683.0, "length": 163, "protein_name": "ADP-ribosylation factor-like protein 2-binding protein", "gene_name": "Arl2bp", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-like protein 2-binding protein isoform 1", "refseq_ac": "NP_001020077", "gene_names_uniprotkb": "Arl2bp; Bart1; Bart", "gene_names_refseq": "Arl2bp", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 2-binding protein; ARF-like 2-binding protein; Binder of ARF2 protein 1", "protein_names_refseq": "ADP-ribosylation factor like GTPase 2 binding protein; ADP-ribosylation factor-like 2 binding protein; ADP-ribosylation factor-like protein 2-binding protein isoform 1; ADP-ribosylation factor-like protein 2-binding protein; ARF-like 2-binding protein; binder of ARF2 protein 1", "tax_id": 10116, "disease": "retinitis pigmentosa with or without situs inversus (Disease Ontology:DOID:0110419); male infertility (Disease Ontology:DOID:12336)", "pathway": " (rno:498910); (R-RNO-83936)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11809823", "class_list": "", "function": "Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein;GO:0051457 maintenance of protein location in nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8C5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12020-1", "uniprot_id": "CRIS1_RAT", "mass": 27847.0, "length": 246, "protein_name": "Cysteine-rich secretory protein 1", "gene_name": "Crisp1; Crisp3", "organism": "Rat", "refseq_name": "cysteine-rich secretory protein 1 precursor", "refseq_ac": "NP_074050", "gene_names_uniprotkb": "Crisp1; Crisp3; Aeg", "gene_names_refseq": "Aeg; Crisp3", "protein_names_uniprotkb": "Cysteine-rich secretory protein 1; 32 kDa epididymal protein; Acidic epididymal glycoprotein; Protein D; Protein E; Protein IV; SCP; Sialoprotein; Sperm-coating glycoprotein", "protein_names_refseq": "32 kDa epididymal protein; SCP; acidic epididymal glycoprotein D/E; cysteine-rich secretory protein 1 precursor; protein D; protein E; protein IV; sialoprotein; sperm-coating glycoprotein", "tax_id": 10116, "disease": "", "pathway": " (rno:64827)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17482178;17671267;18703418;21593480;2460753;30520133;3780731", "class_list": "", "function": "CRISP1 interacts with sperm transiently, possibly with a specific receptor on the sperm surface, consistent with its action in suppressing capacitation during epididymal storage of sperm, [RefSeq, PubMed]; CRISP1 participates not only in sperm-egg fusion but also in the prior stage of sperm-ZP interaction., [RefSeq, PubMed]; Involvement of CRISP1-Zn(2+) complexes in the association of the loosely bound population of CRISP1 with sperm during epididymal maturation, [RefSeq, PubMed]; Knockdown of AEG-1 suppresses autophagy in DCM by downregulating the expression of KLF4. This study provide first-notion evidence for the potential value of AEG-1 as a therapeutic target for the treatment of the patients with DCM., [RefSeq, PubMed]; Recombinant Crisp1 is able to elicit a specific immune response and inhibit male and female fertility, supporting the use of this sperm epididymal protein for the development of an immunocontraceptive approach., [RefSeq, PubMed]; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0042581 specific granule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P12020-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FWY5-1", "uniprot_id": "AIP_RAT", "mass": 37599.0, "length": 330, "protein_name": "AH receptor-interacting protein", "gene_name": "Aip", "organism": "Rat", "refseq_name": "AH receptor-interacting protein", "refseq_ac": "NP_758830", "gene_names_uniprotkb": "Aip; Xap2", "gene_names_refseq": "Aip; XAP2", "protein_names_uniprotkb": "AH receptor-interacting protein; AIP; Aryl-hydrocarbon receptor-interacting protein; Immunophilin XAP2", "protein_names_refseq": "AH receptor-interacting protein; HBV-X associated protein; aryl-hydrocarbon receptor-interacting protein; immunophilin XAP2", "tax_id": 10116, "disease": "pituitary adenoma 1 (Disease Ontology:DOID:0112009)", "pathway": " (rno:282827)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12810716;16085934;23702468;27706259;34588620", "class_list": "", "function": "Aip regulates cAMP signalling and growth hormone secretion in GH3 cells. Publication Status: Online-Only, [RefSeq, PubMed]; May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting., [UniProtKB, UniProtKB, UniProtKB]; RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas. Erratum:[Oncogene. 2023 Dec;42(49):3655-3656. doi: 10.1038/s41388-023-02862-9. PMID: 37932482], [RefSeq, PubMed]; Results demonstrated that Aip inactivation promoted somatotroph tumorigenesis and overproduction of growth hormone probably through increased Stat3 activation. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that XAP2 functionally interacts with PDE4A5 in cells, [RefSeq, PubMed]; The role of Xap2 and C-terminal hsp-70 interacting protein on the endogenous Ah receptors expressed in rat cell lines was determined., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGW7", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0051082 unfolded protein binding;GO:0017162 aryl hydrocarbon receptor binding;GO:0036004 GAF domain binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034751 aryl hydrocarbon receptor complex", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006626 protein targeting to mitochondrion;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5FWY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32305-1", "uniprot_id": "5HT7R_RAT", "mass": 49837.0, "length": 448, "protein_name": "5-hydroxytryptamine receptor 7", "gene_name": "Htr7", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 7 isoform 2", "refseq_ac": "NP_075227", "gene_names_uniprotkb": "Htr7", "gene_names_refseq": "5Ht7; Htr7", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 7; 5-HT-7; 5-HT-X; 5-HT7; GPRFO; Serotonin receptor 7", "protein_names_refseq": "5-HT-7; 5-HT-X; 5-HT7; 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; 5-hydroxytryptamine receptor 7 isoform 2; GPRFO; high affinity serotonin receptor (5HT7); serotonin receptor 7", "tax_id": 10116, "disease": "amnestic disorder (Disease Ontology:DOID:10914); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); childhood absence epilepsy (Disease Ontology:DOID:1825); anxiety disorder (Disease Ontology:DOID:2030); migraine (Disease Ontology:DOID:6364); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:65032); (R-RNO-390666); (R-RNO-9706019)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "31846086;32329363;34199392;36344870;8394362;8397408;8398139;8517926;9084407", "class_list": "", "function": "Blockade of 5-HT2 receptors with sarpogrelate uncovers 5-HT7 receptors inhibiting the tachycardic sympathetic drive in pithed rats., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:8394362, PubMed:8397408, PubMed:8398139). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:8394362). HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:8394362)., [UniProtKB, PubMed, PubMed, PubMed]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity., [UniProtKB, UniProtKB]; Habenula as a Possible Target for Treatment-Resistant Depression Phenotype in Wistar Kyoto Rats., [RefSeq, PubMed]; The role of 5-HT7 receptors on isoproterenol-induced myocardial infarction in rats with high-fat diet exacerbated coronary endothelial dysfunction., [RefSeq, PubMed]; Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar Spinal Blockade of 5-HT7 Receptors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P97936", "ec_number_list": "", "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043679 axon terminus;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007613 memory;GO:0010976 positive regulation of neuron projection development;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007210 serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32305-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55009-1", "uniprot_id": "AIF1_RAT", "mass": 16827.0, "length": 147, "protein_name": "Allograft inflammatory factor 1", "gene_name": "Aif1", "organism": "Rat", "refseq_name": "allograft inflammatory factor 1", "refseq_ac": "NP_058892", "gene_names_uniprotkb": "Aif1; Iba1; Mrf1", "gene_names_refseq": "Aif1; BART-1; Bart1; iba1; mrf-1", "protein_names_uniprotkb": "Allograft inflammatory factor 1; AIF-1; Ionized calcium-binding adapter molecule 1; MRF-1; Microglia response factor", "protein_names_refseq": "AIF-1; allograft inflammatory factor 1; balloon angioplasty responsive transcript; balloon angioplasty-responsive transcript 1; ionized calcium binding adapter molecule 1; microglia response factor; protein BART-1", "tax_id": 10116, "disease": "meningoencephalitis (Disease Ontology:DOID:10554); Alzheimer's disease (Disease Ontology:DOID:10652); interstitial cystitis (Disease Ontology:DOID:13949); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); cerebral palsy (Disease Ontology:DOID:1969); motor neuron disease (Disease Ontology:DOID:231); brain ischemia (Disease Ontology:DOID:2316); glomerulonephritis (Disease Ontology:DOID:2921); brain infarction (Disease Ontology:DOID:3454); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:29427)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15060004;29393594;34576050;35296205;35913387;37958812;37976702;7769138;7783423;8713135;9698327", "class_list": "", "function": "Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play an role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity)., [UniProtKB]; Allograft inflammatory factor-1 enhances inflammation and oxidative stress via the NF-kappaB pathway of bladder urothelium in diabetic rat model., [RefSeq, PubMed]; Histopathological evaluation of IBA-1, GFAP activity in the brain cortex of rats administered cadmium chloride., [RefSeq, PubMed]; Human Milk Oligosaccharide 2'-Fucosyllactose Induces Neuroprotection from Intracerebral Hemorrhage Stroke. Publication Status: Online-Only, [RefSeq, PubMed]; Neurotoxic and cardiotoxic effects of N-methyl-1-(naphthalen-2-yl)propan-2-amine (methamnetamine) and 1-phenyl-2-pyrrolidinylpentane (prolintane)., [RefSeq, PubMed]; Switching Rat Resident Macrophages from M1 to M2 Phenotype by Iba1 Silencing Has Analgesic Effects in SNL-Induced Neuropathic Pain. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P55007;P70491", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament", "go_biological_process": "GO:0030046 parallel actin filament bundle assembly;GO:0071677 positive regulation of mononuclear cell migration;GO:0001934 positive regulation of protein phosphorylation;GO:0006911 phagocytosis, engulfment;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P55009-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70610-1", "uniprot_id": "DOC2B_RAT", "mass": 45841.0, "length": 412, "protein_name": "Double C2-like domain-containing protein beta", "gene_name": "Doc2b", "organism": "Rat", "refseq_name": "double C2-like domain-containing protein beta", "refseq_ac": "NP_112404", "gene_names_uniprotkb": "Doc2b", "gene_names_refseq": "Doc2b", "protein_names_uniprotkb": "Double C2-like domain-containing protein beta; Doc2-beta", "protein_names_refseq": "doc2-beta; double C2, beta; double C2-like domain-containing protein beta; double C2-like domains, beta", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:81820)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15033971;18596155;20150444;22673903;23427263;24356452;26195798;26395669;9115738;9804756", "class_list": "", "function": "Acts directly on membranes and stabilizes hemifusion intermediate in cell-free system Publication Status: Online-Only, [RefSeq, PubMed]; Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes., [UniProtKB, PubMed, PubMed]; Doc2b exocytotic functions appear to be distinct from how synaptotagmin-1 promotes synaptic neurotransmitter release., [RefSeq, PubMed]; Mutations that disrupt Ca(2)-binding activity endow Doc2beta with novel functional properties during synaptic transmission., [RefSeq, PubMed]; These data reveal the key determinants of Doc2beta that underlie its function during the slow phase of synaptic transmission., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019905 syntaxin binding;GO:0005544 calcium-dependent phospholipid binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0008104 intracellular protein localization;GO:0031340 positive regulation of vesicle fusion;GO:0006887 exocytosis;GO:0045956 positive regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70610-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18916-1", "uniprot_id": "ACHG_RAT", "mass": 58621.0, "length": 519, "protein_name": "Acetylcholine receptor subunit gamma", "gene_name": "Chrng; Eif4e2", "organism": "Rat", "refseq_name": "acetylcholine receptor subunit gamma precursor", "refseq_ac": "NP_062018", "gene_names_uniprotkb": "Chrng; Eif4e2; Achrg; Chrng", "gene_names_refseq": "ACHRG; Chrng", "protein_names_uniprotkb": "Acetylcholine receptor subunit gamma", "protein_names_refseq": "AChR gamma subunit; acetylcholine receptor subunit gamma precursor; acetylcholine receptor subunit gamma; cholinergic receptor, nicotinic gamma; cholinergic receptor, nicotinic, gamma (muscle); cholinergic receptor, nicotinic, gamma polypeptide", "tax_id": 10116, "disease": "contractures, pterygia, and spondylocarpotarsal fusion syndrome (Disease Ontology:DOID:0080110)", "pathway": " (rno:25753); (R-RNO-629587)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1702709;3666131", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB, UniProtKB]; Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression. Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0031625 ubiquitin protein ligase binding;GO:0000340 RNA 7-methylguanosine cap binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0042391 regulation of membrane potential;GO:0095500 acetylcholine receptor signaling pathway;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18916-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8D6-1", "uniprot_id": "BRF2_RAT", "mass": 46596.0, "length": 416, "protein_name": "Transcription factor IIIB 50 kDa subunit", "gene_name": "Brf2", "organism": "Rat", "refseq_name": "transcription factor IIIB 50 kDa subunit", "refseq_ac": "NP_001019944", "gene_names_uniprotkb": "Brf2", "gene_names_refseq": "Brf2", "protein_names_uniprotkb": "Transcription factor IIIB 50 kDa subunit; B-related factor 2; BRF-2", "protein_names_refseq": "B-related factor 2; BRF-2; BRF2, RNA polymerase III transcription initiation factor 50 subunit; BRF2, RNA polymerase III transcription initiation factor subunit; BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like; transcription factor IIIB 50 kDa subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:306542); (R-RNO-76071)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017025 TBP-class protein binding;GO:0016251 RNA polymerase II general transcription initiation factor activity;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000126 transcription factor TFIIIB complex", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0006359 regulation of transcription by RNA polymerase III;GO:0070897 transcription preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8D6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00495-1", "uniprot_id": "CSF1R_RAT", "mass": 109264.0, "length": 978, "protein_name": "Macrophage colony-stimulating factor 1 receptor", "gene_name": "Csf1r", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Csf1r; Csfmr; Fms", "gene_names_refseq": "", "protein_names_uniprotkb": "Macrophage colony-stimulating factor 1 receptor; 2.7.10.1; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms", "protein_names_refseq": "", "tax_id": 10116, "disease": "CSF1R-related brain malformation and osteopetrosis (Disease Ontology:DOID:0070343); bone development disease (Disease Ontology:DOID:0080006); colorectal carcinoma (Disease Ontology:DOID:0080199); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (Disease Ontology:DOID:0080523); stomach cancer (Disease Ontology:DOID:10534); crescentic glomerulonephritis (Disease Ontology:DOID:13139); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); colon adenocarcinoma (Disease Ontology:DOID:234); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); infertility (Disease Ontology:DOID:5223); lung small cell carcinoma (Disease Ontology:DOID:5409); lymphopenia (Disease Ontology:DOID:614); hepatocellular carcinoma (Disease Ontology:DOID:684); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:307403); (R-RNO-449836)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1389227;17121910;22673903", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor (By similarity). In the central nervous system, may play a role in the development of microglia macrophages (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.10.2;2.7.12.2;2.7.1.40;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.32;2.7.1.82;2.7.11.23", "go_molecular_function": "GO:0005011 macrophage colony-stimulating factor receptor activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:1990682 CSF1-CSF1R complex;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043204 perikaryon", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0030316 osteoclast differentiation;GO:0038145 macrophage colony-stimulating factor signaling pathway;GO:0045124 regulation of bone resorption;GO:1905523 positive regulation of macrophage migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q00495-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1LZ50-1", "uniprot_id": "DNM3L_RAT", "mass": 48279.0, "length": 422, "protein_name": "DNA (cytosine-5)-methyltransferase 3-like", "gene_name": "Dnmt3l", "organism": "Rat", "refseq_name": "DNA (cytosine-5)-methyltransferase 3-like", "refseq_ac": "NP_001003964", "gene_names_uniprotkb": "Dnmt3l", "gene_names_refseq": "Dnmt3l", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 3-like", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase 3-like; DNA (cytosine-5-)-methyltransferase 3-like", "tax_id": 10116, "disease": "choline deficiency disease (Disease Ontology:DOID:8456)", "pathway": " (rno:309680)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15203217", "class_list": "", "function": "Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context. Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain. Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (By similarity). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (By similarity). Plays a key role in embryonic stem cells and germ cells. In germ cells, required for the methylation of imprinted loci together with DNMT3A. In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization. Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation. While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes. Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes. Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035098 ESC/E(Z) complex;GO:1902494 catalytic complex", "go_biological_process": "GO:0060718 chorionic trophoblast cell differentiation;GO:0007283 spermatogenesis;GO:0045471 response to ethanol;GO:0048863 stem cell differentiation;GO:0090310 negative regulation of DNA methylation-dependent heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LZ50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10067-1", "uniprot_id": "CRGD_RAT", "mass": 21104.0, "length": 174, "protein_name": "Gamma-crystallin D", "gene_name": "Crygd", "organism": "Rat", "refseq_name": "gamma-crystallin D", "refseq_ac": "NP_149086", "gene_names_uniprotkb": "Crygd", "gene_names_refseq": "Cryg4; Crygd; Len", "protein_names_uniprotkb": "Gamma-crystallin D; Gamma-D-crystallin; Gamma-crystallin 2-2", "protein_names_refseq": "Crystallin, gamma polypeptide 4; gamma-D-crystallin; gamma-crystallin 2-2; gamma-crystallin D", "tax_id": 10116, "disease": "limb ischemia (Disease Ontology:DOID:0050852); left ventricular failure (Disease Ontology:DOID:0051064); cataract 4 multiple types (Disease Ontology:DOID:0110234); cataract 2 multiple types (Disease Ontology:DOID:0110235); cataract 7 (Disease Ontology:DOID:0110260); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypothyroidism (Disease Ontology:DOID:1459); bipolar disorder (Disease Ontology:DOID:3312); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:24278)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23404175;27517863;2777080;3783678;7849105", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB]; The Met1Val substitution in CrygD is almost certainly the cause of cataracts in the SS/Jr-Ctr rat strain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007601 visual perception;GO:0043434 response to peptide hormone;GO:0034614 cellular response to reactive oxygen species;GO:0001654 eye development;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P10067-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8K2-1", "uniprot_id": "CTBL1_RAT", "mass": 64948.0, "length": 563, "protein_name": "Beta-catenin-like protein 1", "gene_name": "Ctnnbl1", "organism": "Rat", "refseq_name": "beta-catenin-like protein 1", "refseq_ac": "NP_001020041", "gene_names_uniprotkb": "Ctnnbl1", "gene_names_refseq": "Ctnnbl1", "protein_names_uniprotkb": "Beta-catenin-like protein 1; NAP; Nuclear-associated protein", "protein_names_refseq": "NAP; beta catenin-like 1; beta-catenin-like protein 1; nuclear-associated protein", "tax_id": 10116, "disease": "immunodeficiency 99 (Disease Ontology:DOID:0061069); morbid obesity (Disease Ontology:DOID:11981); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:296320); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0000974 Prp19 complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0043065 positive regulation of apoptotic process;GO:0002250 adaptive immune response;GO:0008380 RNA splicing;GO:0016445 somatic diversification of immunoglobulins", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8K2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11884-1", "uniprot_id": "ALDH2_RAT", "mass": 56488.0, "length": 519, "protein_name": "Aldehyde dehydrogenase, mitochondrial", "gene_name": "Acad10; Aldh2", "organism": "Rat", "refseq_name": "aldehyde dehydrogenase, mitochondrial precursor", "refseq_ac": "NP_115792", "gene_names_uniprotkb": "Acad10; Aldh2; Aldh2", "gene_names_refseq": "Aldh2", "protein_names_uniprotkb": "Aldehyde dehydrogenase, mitochondrial; 1.2.1.3; ALDH class 2; ALDH-E2; ALDH1", "protein_names_refseq": "ALDH class 2; ALDH-E2; ALDH1; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase 2, mitochondrial; aldehyde dehydrogenase, mitochondrial precursor; aldehyde dehydrogenase, mitochondrial; mitochondrial aldehyde dehydrogenase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic cancer (Disease Ontology:DOID:1793); brain infarction (Disease Ontology:DOID:3454); liver disease (Disease Ontology:DOID:409); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29539); (rno:304500); (R-RNO-380612); (R-RNO-71384); (R-RNO-9837999)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10721992;12893989;1699808;1898068;2540003;26446791;3342060;34502162;34725563;35503616;35567426;36720319", "class_list": "", "function": "ALDH2/SIRT1 Contributes to Type 1 and Type 2 Diabetes-Induced Retinopathy through Depressing Oxidative Stress. Publication Status: Online-Only, [RefSeq, PubMed]; Acetaldehyde dehydrogenase 2 activation attenuates sepsis-induced brain injury through NLRP3 inflammasome regulation., [RefSeq, PubMed]; Activation of aldehyde dehydrogenase 2 protects ethanol-induced osteonecrosis of the femoral head in rat model., [RefSeq, PubMed]; Mechanism of ALDH2 improves the neuronal damage caused by hypoxia/reoxygenation., [RefSeq, PubMed]; Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6Q288;Q6Q289;Q6Q290;Q8K3V8;Q91ZD7", "ec_number_list": "6.1.1.5;1.3.8.5;6.2.1.4;4.98.1.1;5.6.2.3;2.8.3.5;2.3.1.-;2.3.1.41;3.4.21.92;3.5.3.1;3.1.2.2;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.2.-;1.1.1.37;6.4.1.3;7.1.2.2;1.4.1.3;1.2.1.5;1.2.1.3;2.3.1.37;4.2.1.2;2.3.1.9;2.3.3.10;5.3.3.8;1.1.1.30;1.2.1.94;3.6.4.10;1.2.4.1;1.2.1.36;1.2.1.19;1.2.1.28;1.1.1.42;5.6.1.7;1.3.8.1;2.7.1.23;1.2.1.7;1.2.1.48;1.2.4.2;5.3.3.21;2.7.11.2;2.7.11.-;1.2.1.31;1.2.1.8;7.1.1.2;1.7.1.-;1.8.1.4;2.3.3.1;3.4.21.53;1.1.1.41;4.2.1.3;1.2.1.47;1.2.1.46", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0070404 NADH binding;GO:0106435 carboxylesterase activity;GO:0008957 phenylacetaldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0001889 liver development;GO:0002931 response to ischemia;GO:0032496 response to lipopolysaccharide;GO:0035094 response to nicotine;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P11884-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2QDE7-1", "uniprot_id": "DNSL1_RAT", "mass": 35182.0, "length": 312, "protein_name": "Deoxyribonuclease-1-like 1", "gene_name": "Dnase1l1", "organism": "Rat", "refseq_name": "deoxyribonuclease-1-like 1 precursor", "refseq_ac": "NP_001014245", "gene_names_uniprotkb": "Dnase1l1", "gene_names_refseq": "Dnase1l1", "protein_names_uniprotkb": "Deoxyribonuclease-1-like 1; 3.1.21.-; DNase I-like 1; DNase X; Deoxyribonuclease I-like 1", "protein_names_refseq": "DNase I-like 1; DNase X; deoxyribonuclease I-like 1; deoxyribonuclease-1-like 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:363522); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16107205", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;2.3.2.5;2.7.1.35;3.4.24.34;3.2.1.17;3.5.3.1;2.3.1.16;2.3.1.9;2.3.1.155;3.4.23.5;1.4.3.22;1.4.3.-;3.1.3.48;3.1.21.-;3.5.1.3;2.7.10.2;3.4.19.9;1.8.3.2;3.2.1.166;3.6.1.6;3.2.1.18;3.4.18.1", "go_molecular_function": "GO:0003677 DNA binding;GO:0004530 deoxyribonuclease I activity;GO:0016787 hydrolase activity;GO:0004519 endonuclease activity;GO:0004536 DNA nuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006308 DNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2QDE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVH4-1", "uniprot_id": "AKTIP_RAT", "mass": 32992.0, "length": 292, "protein_name": "AKT-interacting protein", "gene_name": "Aktip", "organism": "Rat", "refseq_name": "AKT-interacting protein", "refseq_ac": "NP_001011926", "gene_names_uniprotkb": "Aktip; Fts", "gene_names_refseq": "Aktip; Fts", "protein_names_uniprotkb": "AKT-interacting protein; Fused toes protein homolog", "protein_names_refseq": "AKT-interacting protein; fused toes protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:291906)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070695 FHF complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0015031 protein transport;GO:0006915 apoptotic process;GO:0007032 endosome organization;GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13205-1", "uniprot_id": "ANFB_RAT", "mass": 13656.0, "length": 121, "protein_name": "Natriuretic peptides B", "gene_name": "Nppb", "organism": "Rat", "refseq_name": "natriuretic peptides B precursor", "refseq_ac": "NP_113733", "gene_names_uniprotkb": "Nppb", "gene_names_refseq": "BNP; Bnf; Nppb", "protein_names_uniprotkb": "Natriuretic peptides B; 5 kDa cardiac natriuretic peptide; BNP; Brain natriuretic factor prohormone; Brain natriuretic peptide; Gamma-brain natriuretic peptide; Iso-ANP; preproBNP; proBNP", "protein_names_refseq": "Brain natriuretic factor; brain natriuretic factor prohormone; brain natriuretic peptide; gamma-brain natriuretic peptide; iso-ANP; natriuretic peptide precursor B; natriuretic peptide precursor type B; natriuretic peptides B precursor; natriuretic peptides B; preproBNP; proBNP", "tax_id": 10116, "disease": "left ventricular failure (Disease Ontology:DOID:0051064); polycystic kidney disease (Disease Ontology:DOID:0080322); COVID-19 (Disease Ontology:DOID:0080600); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); sickle cell anemia (Disease Ontology:DOID:10923); adult respiratory distress syndrome (Disease Ontology:DOID:11394); heart disease (Disease Ontology:DOID:114); hypertensive heart disease (Disease Ontology:DOID:11516); morbid obesity (Disease Ontology:DOID:11981); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); Kawasaki disease (Disease Ontology:DOID:13378); atherosclerosis (Disease Ontology:DOID:1936); nephrosis (Disease Ontology:DOID:2527); acute kidney failure (Disease Ontology:DOID:3021); liver cirrhosis (Disease Ontology:DOID:5082); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); hyperhomocysteinemia (Disease Ontology:DOID:9279); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); systolic heart failure (Disease Ontology:DOID:9651); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25105)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "1837590;2144113;2522776;2525379;2525380;2528349;2673236;30980393;33970224;34359915;35776316;36307995;9252368", "class_list": "", "function": "CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors., [RefSeq, PubMed]; Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:2525380, PubMed:9252368). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (By similarity). Likely involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, kaluresis and chloruresis (PubMed:2525380, PubMed:9252368)., [UniProtKB, UniProtKB, PubMed, PubMed]; Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh exudates swabbed from critically colonised and infected full-thickness wounds in rats., [RefSeq, PubMed]; Piezo1 Mechanosensitive Ion Channel Mediates Stretch-Induced Nppb Expression in Adult Rat Cardiac Fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; ZAKbeta Alleviates Oxidized Low-density Lipoprotein (ox-LDL)-Induced Apoptosis and B-type Natriuretic Peptide (BNP) Upregulation in Cardiomyoblast., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0051427 hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex;GO:0005576 extracellular region", "go_biological_process": "GO:1904681 response to 3-methylcholanthrene;GO:0006182 cGMP biosynthetic process;GO:0007218 neuropeptide signaling pathway;GO:0007507 heart development;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P13205-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KM79-1", "uniprot_id": "DUS11_RAT", "mass": 38068.0, "length": 326, "protein_name": "RNA/RNP complex-1-interacting phosphatase", "gene_name": "Dusp11", "organism": "Rat", "refseq_name": "RNA/RNP complex-1-interacting phosphatase", "refseq_ac": "NP_001020821", "gene_names_uniprotkb": "Dusp11; Pir1", "gene_names_refseq": "Dusp11", "protein_names_uniprotkb": "RNA/RNP complex-1-interacting phosphatase; 3.1.3.-; Dual specificity protein phosphatase 11; Phosphatase that interacts with RNA/RNP complex 1", "protein_names_refseq": "RNA/RNP complex-1-interacting phosphatase-like; RNA/RNP complex-1-interacting phosphatase; dual specificity phosphatase 11 (RNA/RNP complex 1-interacting); dual specificity protein phosphatase 11; phosphatase that interacts with RNA/RNP complex 1", "tax_id": 10116, "disease": "", "pathway": " (rno:297412)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0016791 phosphatase activity;GO:0004651 polynucleotide 5'-phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005634 nucleus", "go_biological_process": "GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PPJ4-1", "uniprot_id": "DOHH_RAT", "mass": 33077.0, "length": 302, "protein_name": "Deoxyhypusine hydroxylase", "gene_name": "Dohh", "organism": "Rat", "refseq_name": "deoxyhypusine hydroxylase", "refseq_ac": "NP_001020177", "gene_names_uniprotkb": "Dohh; DOHH", "gene_names_refseq": "Dohh; RGD1304783", "protein_names_uniprotkb": "Deoxyhypusine hydroxylase; 1.14.99.29; DOHH; Deoxyhypusine dioxygenase; Deoxyhypusine monooxygenase", "protein_names_refseq": "deoxyhypusine dioxygenase; deoxyhypusine hydroxylase/monooxygenase; deoxyhypusine hydroxylase; deoxyhypusine monooxygenase", "tax_id": 10116, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:314644); (R-RNO-204626)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.99.29", "go_molecular_function": "GO:0019135 deoxyhypusine monooxygenase activity;GO:0005506 iron ion binding;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0008612 peptidyl-lysine modification to peptidyl-hypusine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PPJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60705-1", "uniprot_id": "ABEC3_RAT", "mass": 51084.0, "length": 429, "protein_name": "DNA dC->dU-editing enzyme APOBEC3", "gene_name": "Apobec3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Apobec3; Apobec3b", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA dC->dU-editing enzyme APOBEC3; 3.5.4.38", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-72200); (R-RNO-75094)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12859895", "class_list": "", "function": "DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.4.38;3.5.4.-;3.5.4.36", "go_molecular_function": "GO:0003723 RNA binding;GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0016554 cytidine to uridine editing;GO:0051607 defense response to virus;GO:0070383 DNA cytosine deamination;GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60705-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11883-1", "uniprot_id": "AL3A1_RAT", "mass": 50339.0, "length": 453, "protein_name": "Aldehyde dehydrogenase, dimeric NADP-preferring", "gene_name": "Aldh3a1", "organism": "Rat", "refseq_name": "aldehyde dehydrogenase, dimeric NADP-preferring", "refseq_ac": "NP_114178", "gene_names_uniprotkb": "Aldh3a1; Aldd; Aldh3", "gene_names_refseq": "AHDC; Ahd-c; Aldh3a1; Aldh3; Aldh", "protein_names_uniprotkb": "Aldehyde dehydrogenase, dimeric NADP-preferring; 1.2.1.5; Aldehyde dehydrogenase family 3 member A1; HTC-ALDH; Tumor-associated aldehyde dehydrogenase", "protein_names_refseq": "Aldehyde dehydrogenase (Ahd-c); HTC-ALDH; aldehyde dehydrogenase 3A1; aldehyde dehydrogenase class 3; aldehyde dehydrogenase family 3 member A1; aldehyde dehydrogenase family 3 subfamily A1; aldehyde dehydrogenase, dimeric NADP-preferring; tumor-associated aldehyde dehydrogenase tumor ALDH", "tax_id": 10116, "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270); Sjogren-Larsson syndrome (Disease Ontology:DOID:14501); arteriosclerosis (Disease Ontology:DOID:2349)", "pathway": " (rno:25375); (R-RNO-211945)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17530188;2091023;26674287;2713359;2831537;8509394;9095201", "class_list": "", "function": "ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:2831537). Preferentially oxidizes aromatic aldehyde substrates (PubMed:2831537). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity)., [UniProtKB, PubMed, UniProtKB]; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light., [UniProtKB, UniProtKB]; Decreased function of dopamine mediated through DA D(2) receptor in the cerebral cortex and brain stem enhanced the brain, plasma and liver ALDH activity in ethanol treated rats., [RefSeq, PubMed]; Different doxorubicin formulations decreased liver expression of ALDH3A1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.2.1.5;1.2.1.3;1.2.1.94;1.2.1.36;1.2.1.19;1.2.1.28;1.2.1.7;1.2.1.48;1.2.1.31;1.2.1.8;1.7.1.-;1.2.1.47;1.2.1.46", "go_molecular_function": "GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0018479 benzaldehyde dehydrogenase (NAD+) activity;GO:0008106 alcohol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007584 response to nutrient;GO:0008284 positive regulation of cell population proliferation;GO:0001666 response to hypoxia;GO:0006081 aldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P11883-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7E1-1", "uniprot_id": "ELF3_RAT", "mass": 44521.0, "length": 395, "protein_name": "ETS-related transcription factor Elf-3", "gene_name": "Elf3", "organism": "Rat", "refseq_name": "ETS-related transcription factor Elf-3", "refseq_ac": "NP_001019939", "gene_names_uniprotkb": "Elf3", "gene_names_refseq": "Elf3", "protein_names_uniprotkb": "ETS-related transcription factor Elf-3; E74-like factor 3", "protein_names_refseq": "E74-like factor 3; ETS-related transcription factor Elf-3", "tax_id": 10116, "disease": "", "pathway": " (rno:304815); (R-RNO-1912408)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32439949", "class_list": "", "function": "High glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KLP0-1", "uniprot_id": "DHTK1_RAT", "mass": 102642.0, "length": 920, "protein_name": "2-oxoadipate dehydrogenase complex component E1", "gene_name": "Dhtkd1", "organism": "Rat", "refseq_name": "2-oxoadipate dehydrogenase complex component E1", "refseq_ac": "NP_001020891", "gene_names_uniprotkb": "Dhtkd1", "gene_names_refseq": "Dhtkd1; E1a; OADC-E1; OADH-E1", "protein_names_uniprotkb": "2-oxoadipate dehydrogenase complex component E1; 1.2.4.-; 2-oxoadipate dehydrogenase, mitochondrial; Alpha-KADH-E1; Alpha-ketoadipate dehydrogenase; Dehydrogenase E1 and transketolase domain-containing protein 1; E1a; OADC-E1; OADH-E1; Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial", "protein_names_refseq": "2-oxoadipate dehydrogenase complex component E1; 2-oxoadipate dehydrogenase, mitochondrial; alpha-KADH-E1; alpha-ketoadipate dehydrogenase; dehydrogenase E1 and transketolase domain-containing protein 1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial-like; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease axonal type 2Q (Disease Ontology:DOID:0110170); 2-aminoadipic 2-oxoadipic aciduria (Disease Ontology:DOID:0111453)", "pathway": " (rno:361272); (R-RNO-9858328)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "28601082;32024885", "class_list": "", "function": "2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues. Publication Status: Online-Only, [RefSeq, PubMed]; Thiamine Induces Long-Term Changes in Amino Acid Profiles and Activities of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases in Rat Brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.61;2.3.1.-;1.2.4.-;1.8.1.4", "go_molecular_function": "GO:0030976 thiamine pyrophosphate binding;GO:0160166 2-oxoadipate dehydrogenase activity;GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor", "go_cellular_component": "GO:0005739 mitochondrion;GO:0160167 oxoadipate dehydrogenase complex", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0006096 glycolytic process;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KLP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05371-1", "uniprot_id": "CLUS_RAT", "mass": 51375.0, "length": 447, "protein_name": "Clusterin", "gene_name": "Clu", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Clu", "gene_names_refseq": "", "protein_names_uniprotkb": "Clusterin; DAG; Dimeric acid glycoprotein; SGP-2; Sulfated glycoprotein 2; TRPM-2; Testosterone repressed prostate message 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); renal fibrosis (Disease Ontology:DOID:0050855); gelatinous drop-like corneal dystrophy (Disease Ontology:DOID:0060449); muscular disease (Disease Ontology:DOID:0080000); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); prostatic hypertrophy (Disease Ontology:DOID:11132); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); cicatricial pemphigoid (Disease Ontology:DOID:11656); Kawasaki disease (Disease Ontology:DOID:13378); exfoliation syndrome (Disease Ontology:DOID:13641); breast cancer (Disease Ontology:DOID:1612); atherosclerosis (Disease Ontology:DOID:1936); brain ischemia (Disease Ontology:DOID:2316); prostate adenocarcinoma (Disease Ontology:DOID:2526); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); inclusion body myositis (Disease Ontology:DOID:3429); systemic scleroderma (Disease Ontology:DOID:418); conjunctival disease (Disease Ontology:DOID:4251); macular retinal edema (Disease Ontology:DOID:4449); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); nasal cavity adenocarcinoma (Disease Ontology:DOID:4930); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); chronic kidney disease (Disease Ontology:DOID:784); retinal degeneration (Disease Ontology:DOID:8466); mycosis fungoides (Disease Ontology:DOID:8691); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:24854); (R-RNO-114608); (R-RNO-6803157); (R-RNO-977606)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10.1039/D0MO00044B;16038898;21454685;22673903;2299741;2920020;34106099;3415696;3651384;7680346", "class_list": "", "function": "Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 34, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0002434 immune complex clearance;GO:0001774 microglial cell activation;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P05371-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49301-1", "uniprot_id": "CLC10_RAT", "mass": 34242.0, "length": 306, "protein_name": "C-type lectin domain family 10 member A", "gene_name": "Clec10a", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Clec10a; Mgl1; Mgl", "gene_names_refseq": "", "protein_names_uniprotkb": "C-type lectin domain family 10 member A; M-ASGP-BP-1; MMGL; Macrophage asialoglycoprotein-binding protein 1; Macrophage galactose/N-acetylgalactosamine-specific lectin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:64195)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2358462;3421964", "class_list": "", "function": "Recognizes terminal galactose and N-acetylgalactosamine units., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005537 D-mannose binding;GO:0042806 fucose binding;GO:0038187 pattern recognition receptor activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0002248 connective tissue replacement involved in inflammatory response wound healing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P49301-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0H8B9-1", "uniprot_id": "CL2DB_RAT", "mass": 23537.0, "length": 207, "protein_name": "C-type lectin domain family 2 member D11", "gene_name": "Clec2d11; Clec2g", "organism": "Rat", "refseq_name": "C-type lectin domain family 2 member D11", "refseq_ac": "NP_001041540", "gene_names_uniprotkb": "Clec2d11; Clec2g; Clrb; Ocil", "gene_names_refseq": "CLEC2D11; Clec2g; Clr-b; Clr11; Clrb; RGD1563148", "protein_names_uniprotkb": "C-type lectin domain family 2 member D11; C-type lectin-related protein B; Clr-b; Lectin-like transmembrane protein; Osteoclast inhibitory lectin", "protein_names_refseq": "C-type lectin domain family 2 member D11; C-type lectin domain family 2, member d11; C-type lectin-related protein 11; C-type lectin-related protein B; Ocil/Clrb-like protein; lectin-like transmembrane protein; osteoclast inhibitory lectin", "tax_id": 10116, "disease": "", "pathway": " (rno:362447)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17462921;22673903", "class_list": "", "function": "Existence of lectin-like genes in several poxviruses suggests that this may represent a common theme for viral evasion of innate immunity, [RefSeq, PubMed]; Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0H8B7;Q0H8B8", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0H8B9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5HZB6-1", "uniprot_id": "CLASR_RAT", "mass": 76807.0, "length": 668, "protein_name": "CLK4-associating serine/arginine rich protein", "gene_name": "Clasrp", "organism": "Rat", "refseq_name": "CLK4-associating serine/arginine rich protein", "refseq_ac": "NP_001019465", "gene_names_uniprotkb": "Clasrp; Sfrs16", "gene_names_refseq": "Clasrp; Sfrs16; Srsf16", "protein_names_uniprotkb": "CLK4-associating serine/arginine rich protein; Splicing factor, arginine/serine-rich 16", "protein_names_refseq": "CLK4-associating serine/arginine rich protein; serine/arginine-rich splicing factor 16; splicing factor, arginine/serine-rich 16", "tax_id": 10116, "disease": "", "pathway": " (rno:499390)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5HZB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14046-1", "uniprot_id": "A1I3_RAT", "mass": 163773.0, "length": 1477, "protein_name": "Alpha-1-inhibitor 3", "gene_name": "A1i3; Mug5; Mug6", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "A1i3; Mug5; Mug6; LOC297568", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-1-inhibitor 3; Alpha-1-inhibitor 3 variant II; Alpha-1-inhibitor III", "protein_names_refseq": "", "tax_id": 10116, "disease": "anterior segment dysgenesis 8 (Disease Ontology:DOID:0080613)", "pathway": " (rno:297568)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1039/D0MO00044B;22673903;24090084;2436907;2472396;2495816;2831216;34106099;34502162", "class_list": "", "function": "Protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function., [UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q4G042;Q63266;Q6LDP2;Q6LDR8", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P14046-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVR7-1", "uniprot_id": "CPSF4_RAT", "mass": 27419.0, "length": 243, "protein_name": "Cleavage and polyadenylation specificity factor subunit 4", "gene_name": "Cpsf4l2; Cpsf4", "organism": "Rat", "refseq_name": "cleavage and polyadenylation specificity factor subunit 4 isoform 1", "refseq_ac": "NP_001012351", "gene_names_uniprotkb": "Cpsf4l2; Cpsf4; Cpsf4l2; LOC100360200", "gene_names_refseq": "Cpsf4", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 4; CPSF 30 kDa subunit; Cleavage and polyadenylation specificity factor 30 kDa subunit", "protein_names_refseq": "CPSF 30 kDa subunit; cleavage and polyadenylation specific factor 4, 30kD subunit; cleavage and polyadenylation specificity factor 30 kDa subunit; cleavage and polyadenylation specificity factor subunit 4 isoform 1; cleavage and polyadenylation specificity factor subunit 4", "tax_id": 10116, "disease": "", "pathway": " (rno:100360200); (rno:304277); (R-RNO-159231); (R-RNO-73856); (R-RNO-77595); (R-RNO-9770562)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70709-1", "uniprot_id": "ECP_RAT", "mass": 18007.0, "length": 155, "protein_name": "Eosinophil cationic protein", "gene_name": "Rnase17; Rnase3", "organism": "Rat", "refseq_name": "eosinophil cationic protein precursor", "refseq_ac": "NP_620257", "gene_names_uniprotkb": "Rnase17; Rnase3; Ear11; Rns3", "gene_names_refseq": "EAR; ECP; Ear11; R1; R7; Rnase3", "protein_names_uniprotkb": "Eosinophil cationic protein; 3.1.27.-; EAR-11; ECP; Eosinophil secondary granule ribonuclease 11; RNase 3; Ribonuclease 3", "protein_names_refseq": "EAR-11; RNase 3; eosinophil cationic protein precursor; eosinophil cationic protein; eosinophil secondary granule ribonuclease 11; eosinophil-associated ribonuclease; eosinophil-associated, ribonuclease A family, member 11; ribonuclease 1; ribonuclease 3; ribonuclease 7; ribonuclease, RNase A family, 3", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156)", "pathway": " (rno:192264); (rno:497195); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "18178677;9116043", "class_list": "", "function": "Cytotoxin and helminthotoxin with ribonuclease activity. Possesses a wide variety of biological activities (By similarity)., [UniProtKB]; Results demonstrate direct, charge-dependent, & long-lasting sensitizing effect of cationic proteins on pulmonary sensory neurons, may contribute to hyperresponsiveness associated with airway infiltration of eosinophils under pathophysiological conditions, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.2.2;3.4.21.4;3.4.16.-;3.2.1.-;5.3.4.1;1.1.1.205;3.2.1.23;5.3.99.3;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.17;3.2.1.31;3.5.3.1;2.7.11.13;2.3.3.8;3.2.1.51;3.4.21.20;1.6.2.2;3.5.3.15;3.5.1.26;3.6.4.6;3.1.6.12;2.4.1.1;2.7.11.24;3.1.27.-;3.4.14.1;3.1.6.4;3.1.6.8;1.6.5.5;3.6.1.-;2.7.10.2;3.4.19.9;3.1.3.16;3.2.1.52;6.3.4.21;3.4.14.2", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006935 chemotaxis;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70709-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3ZRW7-1", "uniprot_id": "CLUL1_RAT", "mass": 53706.0, "length": 464, "protein_name": "Clusterin-like protein 1", "gene_name": "Clul1", "organism": "Rat", "refseq_name": "clusterin-like protein 1 precursor", "refseq_ac": "NP_001028243", "gene_names_uniprotkb": "Clul1", "gene_names_refseq": "Clul1", "protein_names_uniprotkb": "Clusterin-like protein 1", "protein_names_refseq": "clusterin-like 1 (retinal); clusterin-like protein 1 precursor; clusterin-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:367345)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZRW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51870-1", "uniprot_id": "CP4F5_RAT", "mass": 60681.0, "length": 526, "protein_name": "Cytochrome P450 4F5", "gene_name": "Cyp4f37; Cyp4f5", "organism": "Rat", "refseq_name": "cytochrome P450 4F5", "refseq_ac": "NP_775147", "gene_names_uniprotkb": "Cyp4f37; Cyp4f5; Cyp4f37", "gene_names_refseq": "Cyp4f5", "protein_names_uniprotkb": "Cytochrome P450 4F5; 1.14.14.1; CYPIVF5", "protein_names_refseq": "CYPIVF5; cytochrome P450 4F5-like; cytochrome P450 4F5", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:286905); (rno:691312)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12646265;16182239;8554568", "class_list": "", "function": "CYP4F5 and CYP4F6, due to their capacities to metabolize LTB(4), may play important roles in modulating inflammatory response in the lung and to some extent in the brain, kidney, and testis, [RefSeq, PubMed]; CYP4Fs are regionally distributed in the spontaneously hypertensive rat (SHR) kidney with CYP4F1, 4F4, and 4F5 being expressed more highly in the renal cortex than medulla while CYP4F6 shows higher medullary expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904681 response to 3-methylcholanthrene;GO:0006691 leukotriene metabolic process;GO:0044281 small molecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51870-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97605-1", "uniprot_id": "EFNA5_RAT", "mass": 26358.0, "length": 228, "protein_name": "Ephrin-A5", "gene_name": "Efna5", "organism": "Rat", "refseq_name": "ephrin-A5 isoform 1 precursor", "refseq_ac": "NP_446355", "gene_names_uniprotkb": "Efna5; Eplg7; Lerk7", "gene_names_refseq": "Efna5; Lerk7", "protein_names_uniprotkb": "Ephrin-A5; AL-1; EPH-related receptor tyrosine kinase ligand 7; LERK-7", "protein_names_refseq": "AL-1; LERK-7; eph-related receptor tyrosine kinase ligand 7; ephrin-A5 isoform 1 precursor", "tax_id": 10116, "disease": "anencephaly (Disease Ontology:DOID:0060668)", "pathway": " (rno:116683); (R-RNO-2682334); (R-RNO-3928663); (R-RNO-3928665)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "23274893;24222347;29237529;29762250;32396496;7748564", "class_list": "", "function": "Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion (By similarity)., [UniProtKB]; Changes in ephrinA5/EphA5 interactions and synaptic plasticity within the ventromedial hypothalamus may contribute to the impairment in glucagon secretion and counterregulatory responses caused by recurrent hypoglycemia., [RefSeq, PubMed]; Changes in ephrinA5/EphA5 interactions within the ventromedial hypothalamus act in concert with islets to restore glucose homeostasis during acute hypoglycemia, and its effect on counterregulation may be mediated by changes in glutamate/glutamine cycling., [RefSeq, PubMed]; Downregulation of ephrinA5 and EphA5 in the CA3 region of the hippocampus may participate in the mechanism of mossy fiber sprouting and is closely associated with the development and progression of epilepsy., [RefSeq, PubMed]; Erythropoietin-producing hepatocellular receptor A7 restrains estrogen negative feedback of luteinizing hormone via ephrin A5 in the hypothalamus of female rats., [RefSeq, PubMed]; That ephrin-A5 expression may be decreased in congenital hypothyroidism, and abnormal activation of ephrin-A5/EphA5 signaling affects synaptogenesis during brain development, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046875 ephrin receptor binding;GO:0045499 chemorepellent activity;GO:0048018 receptor ligand activity;GO:0005169 neurotrophin TRKB receptor binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0009897 external side of plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0032956 regulation of actin cytoskeleton organization;GO:0048013 ephrin receptor signaling pathway;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0022407 regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97605-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02793-1", "uniprot_id": "FRIL1_RAT", "mass": 20749.0, "length": 183, "protein_name": "Ferritin light chain 1", "gene_name": "Ftl1l1; Ftl1l2; Ftl1l5; Ftl1l7; Ftl1; LOC100360087; LOC100362384; LOC120102993", "organism": "Rat", "refseq_name": "ferritin light chain 1", "refseq_ac": "NP_071945", "gene_names_uniprotkb": "Ftl1l1; Ftl1l2; Ftl1l5; Ftl1l7; Ftl1; LOC100360087; LOC100362384; LOC120102993; AABR07005031.1; AABR07041778.1; AC115277.1; Ftl1-ps14; Ftl1l1; Ftl1l2; Ftl1l5; Ftl1l7; Ftl1; Ftl; LOC100359668; LOC100360087; LOC100362384; LOC120102993; RGD1560687; RGD1566189", "gene_names_refseq": "Ftl1; Ftl", "protein_names_uniprotkb": "Ferritin light chain 1; Ferritin L subunit 1", "protein_names_refseq": "ferritin L subunit 1; ferritin light chain 1; ferritin, light polypeptide", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); neurodegeneration with brain iron accumulation 3 (Disease Ontology:DOID:0110737); hyperferritinemia-cataract syndrome (Disease Ontology:DOID:0111256); neurodegenerative disease (Disease Ontology:DOID:1289); candidiasis (Disease Ontology:DOID:1508); basal ganglia disease (Disease Ontology:DOID:679)", "pathway": " (rno:100359668); (rno:120102993); (rno:29292); (rno:499244); (rno:500804); (rno:501644); (R-RNO-432722); (R-RNO-6798695); (R-RNO-917937)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "15240697;1555892;31674712;33255702;3584116;36446230;6546756", "class_list": "", "function": "Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling., [RefSeq, PubMed]; Reference intervals established using indirect method for serum ferritin assayed on Abbott Architect i2000SR analyzer in Chinese adults., [RefSeq, PubMed]; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Tissue-Specific Ferritin- and GFP-Based Genetic Vectors Visualize Neurons by MRI in the Intact and Post-Ischemic Rat Brain. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7T1", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0008198 ferrous iron binding;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0044754 autolysosome;GO:0070288 ferritin complex", "go_biological_process": "GO:0010288 response to lead ion;GO:0006879 intracellular iron ion homeostasis;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P02793-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51652-1", "uniprot_id": "AKC1H_RAT", "mass": 37300.0, "length": 323, "protein_name": "Aldo-keto reductase family 1 member C18", "gene_name": "Akr1c18; Akr1c19; Akr1c3", "organism": "Rat", "refseq_name": "aldo-keto reductase family 1 member C18", "refseq_ac": "NP_612519", "gene_names_uniprotkb": "Akr1c18; Akr1c19; Akr1c3", "gene_names_refseq": "Akr1c18; Akr1c3", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member C18; 1.1.-.-; 1.1.1.149; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; HSD1", "protein_names_refseq": "20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-hydroxysteroid dehydrogenase; HSD1; aldo-keto reductase family 1 member C18; aldo-keto reductase family 1, member C18; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); ductal carcinoma in situ (Disease Ontology:DOID:0060074); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); 46,XY sex reversal 8 (Disease Ontology:DOID:0111773); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); polycystic ovary syndrome (Disease Ontology:DOID:11612); leukemia (Disease Ontology:DOID:1240); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:171516); (rno:307096); (R-RNO-193368); (R-RNO-193775); (R-RNO-193807); (R-RNO-2162123); (R-RNO-5365859); (R-RNO-975634); (R-RNO-9757110)", "pathway_count": 9, "publication_count": 4, "publication_id_list": "29627526;8024573;8172618;8194472", "class_list": "", "function": "AKR1C3 expression was decreased in the kidneys of L-NAME-induced preeclampsia rats., [RefSeq, PubMed]; Catalyzes the conversion of progesterone into 20-alpha-dihydroprogesterone (20 alpha-OHP)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q498E4", "ec_number_list": "1.1.1.50;1.1.1.149;1.1.-.-;1.1.1.21;1.1.1.-;1.1.1.209", "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0047787 Delta4-3-oxosteroid 5beta-reductase activity;GO:0008106 alcohol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007584 response to nutrient;GO:0008284 positive regulation of cell population proliferation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0071394 cellular response to testosterone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51652-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJP0-1", "uniprot_id": "ALD1_RAT", "mass": 36122.0, "length": 316, "protein_name": "Aldo-keto reductase family 1 member B7", "gene_name": "Akr1b10; Akr1b7", "organism": "Rat", "refseq_name": "aldo-keto reductase family 1 member B7", "refseq_ac": "NP_446233", "gene_names_uniprotkb": "Akr1b10; Akr1b7; Akr1b14; Akr1b15; Akr1b7; Akr1b8", "gene_names_refseq": "Akr1b14; Akr1b7; Avdp; MVDP", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member B7; 1.1.1.21; Aldehyde reductase; Aldose reductase-like protein AKR1B14; Aldose reductase-related protein 1", "protein_names_refseq": "aldehyde reductase; aldo-keto reductase family 1 member B7; aldose reductase-like protein AKR1B14; aldose reductase-related protein 1; androgen regulated vas deferens protein", "tax_id": 10116, "disease": "", "pathway": " (rno:116463); (rno:296972); (R-RNO-193144); (R-RNO-975634)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12193556;15358674;19342790;19809495;21048316;21168333;21586312;22505406", "class_list": "", "function": "AKR1B14 was crystallized from polyethylene glycol solutions using the hanging-drop vapour-diffusion method and an X-ray diffraction data set was collected to 1.86 A resolution., [RefSeq, PubMed]; Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions Publication Status: Online-Only, [RefSeq, PubMed]; Crystal structure of the AKR1B14 His269Arg mutant in complex with NADPH was refined at 1.87 A degrees resolution, [RefSeq, PubMed]; Expression in rat vas deferens is barely detectable and is not androgen sensitive, [RefSeq, PubMed]; Expression of akr1b7 mRNA in rat liver is sexually differentiated, expressed in females but not in males, and regulated by the sexually dimorphic secretion pattern of GH., [RefSeq, PubMed]; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols (PubMed:21048316). Reduces prostaglandins (By similarity). May play a role in the metabolism of xenobiotic aromatic aldehydes., [UniProtKB, UniProtKB, PubMed]; The bile acid binding to AKR1B14 mainly accelerates the NADP(+) dissociation, the rate-limited step of the enzyme reaction, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.21;1.1.1.300;1.1.1.372;1.1.1.54;1.1.1.50;1.1.1.149;1.1.-.-;1.1.1.-;1.1.1.209", "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0036130 prostaglandin H2 endoperoxidase reductase activity;GO:0016491 oxidoreductase activity;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0016918 retinal binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0033574 response to testosterone;GO:0001523 retinoid metabolic process;GO:0042572 retinol metabolic process;GO:0042574 retinal metabolic process;GO:0044597 daunorubicin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5RJP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05704-1", "uniprot_id": "BPIB4_RAT", "mass": 65580.0, "length": 617, "protein_name": "BPI fold-containing family B member 4", "gene_name": "Bpifb4", "organism": "Rat", "refseq_name": "BPI fold-containing family B member 4 precursor", "refseq_ac": "NP_001102679", "gene_names_uniprotkb": "Bpifb4; Lplunc4; Ry2g5", "gene_names_refseq": "Bpifb4; Lplunc4; RY2G5", "protein_names_uniprotkb": "BPI fold-containing family B member 4; Ligand-binding protein RY2G5; Long palate, lung and nasal epithelium carcinoma-associated protein 4", "protein_names_refseq": "BPI fold-containing family B member 4 precursor; ligand-binding protein RY2G5; long palate, lung and nasal epithelium carcinoma-associated protein 4; potential ligand-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:499925); (R-RNO-6803157)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "1915264", "class_list": "", "function": "May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05704-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70560-1", "uniprot_id": "COCA1_RAT", "mass": 32001.0, "length": 317, "protein_name": "Collagen alpha-1(XII) chain", "gene_name": "Col12a1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Col12a1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(XII) chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "Ullrich congenital muscular dystrophy 2 (Disease Ontology:DOID:0060948); Bethlem myopathy 2 (Disease Ontology:DOID:0061201)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10419532", "class_list": "", "function": "Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70559", "ec_number_list": "", "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005595 collagen type XII trimer;GO:0005576 extracellular region", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0001501 skeletal system development;GO:0001886 endothelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P70560-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05178-1", "uniprot_id": "CP2C6_RAT", "mass": 56003.0, "length": 490, "protein_name": "Cytochrome P450 2C6", "gene_name": "Cyp2c6-ps2; Cyp2c66; Cyp2c6; Cyp2c7l1; LOC100911718; LOC120098584; LOC134483996; LOC134485234", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cyp2c6-ps2; Cyp2c66; Cyp2c6; Cyp2c7l1; LOC100911718; LOC120098584; LOC134483996; LOC134485234; Cyp2c-6; Cyp2c6-ps2; Cyp2c66; Cyp2c6_v1-ps2; Cyp2c6l1; Cyp2c6v1l1; Cyp2c6v1; Cyp2c6; Cyp2c7l1; Cyp2c7; LOC100911718; LOC100912265; LOC120093077; LOC120098584; LOC134483996; LOC134485234", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 2C6; 1.14.14.1; CYPIIC6; Cytochrome P450 PB1; PTF2", "protein_names_refseq": "", "tax_id": 10116, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); Keshan disease (Disease Ontology:DOID:0050083); alcohol dependence (Disease Ontology:DOID:0050741); warfarin resistance (Disease Ontology:DOID:0080665); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); eosinophilic esophagitis (Disease Ontology:DOID:13922); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); breast cancer (Disease Ontology:DOID:1612); tuberculosis (Disease Ontology:DOID:399); hyperglycemia (Disease Ontology:DOID:4195); multiple chemical sensitivity (Disease Ontology:DOID:4661); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); peptic ulcer disease (Disease Ontology:DOID:750); end stage renal disease (Disease Ontology:DOID:783); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:100912265); (rno:293989); (R-RNO-211981); (R-RNO-211999); (R-RNO-2142670); (R-RNO-2142816); (R-RNO-9027307); (R-RNO-9749641)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "3015936;3335521;3399405;3801454", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;1.14.14.80", "go_molecular_function": "GO:0008404 arachidonate 14,15-epoxygenase activity;GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016098 monoterpenoid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0031667 response to nutrient levels;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P05178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29321-1", "uniprot_id": "EPHA8_RAT", "mass": 41233.0, "length": 372, "protein_name": "Ephrin type-A receptor 8", "gene_name": "Epha8", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Epha8; Eek", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin type-A receptor 8; 2.7.10.1; EPH- and ELK-related kinase; Tyrosine-protein kinase receptor EEK", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:60589)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1648701", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.10.2;2.7.12.2;2.7.1.40;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.32;2.7.1.82;2.7.11.23", "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005003 ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0031901 early endosome membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0007155 cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016322 neuron remodeling;GO:0030155 regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P29321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54758-1", "uniprot_id": "EPHA6_RAT", "mass": 116209.0, "length": 1035, "protein_name": "Ephrin type-A receptor 6", "gene_name": "Epha6", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Epha6; Ehk-2; Ehk2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin type-A receptor 6; 2.7.10.1; EHK-2; EPH homology kinase 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:29202); (R-RNO-2682334); (R-RNO-3928663); (R-RNO-3928665)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "7504232", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.10.2;2.7.12.2;2.7.1.40;2.7.11.1;2.7.11.13;2.7.10.4;3.6.5.2;2.7.1.32;2.7.1.82;2.7.11.23", "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0016020 membrane", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0007417 central nervous system development;GO:0007411 axon guidance;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P54758-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83941-1", "uniprot_id": "ELOC_RAT", "mass": 12473.0, "length": 112, "protein_name": "Elongin-C", "gene_name": "Elocl1; Eloc", "organism": "Rat", "refseq_name": "elongin-C", "refseq_ac": "NP_001257490", "gene_names_uniprotkb": "Elocl1; Eloc; AABR07035541.3; Eloc; LOC103691088; LOC120099279; LOC134482328; LOC134482331; LOC134482335; LOC134482347; LOC134482356; LOC134482479; LOC134482480; LOC134482485; LOC134482488; Tceb1", "gene_names_refseq": "Eloc; Tceb1", "protein_names_uniprotkb": "Elongin-C; EloC; Elongin 15 kDa subunit; RNA polymerase II transcription factor SIII subunit C; SIII p15; Stromal membrane-associated protein SMAP1B homolog; Transcription elongation factor B polypeptide 1", "protein_names_refseq": "RNA polymerase II transcription factor SIII subunit C; SIII p15; elongation factor SIII p15 subunit; elongin 15 kDa subunit; elongin-C; stromal membrane-associated protein SMAP1B homolog; transcription elongation factor B (SIII), polypeptide 1; transcription elongation factor B polypeptide 1; transcription elongation factor B subunit 1", "tax_id": 10116, "disease": "", "pathway": " (rno:103691088); (rno:64525); (R-RNO-112382); (R-RNO-1234176); (R-RNO-674695); (R-RNO-6796648); (R-RNO-75955); (R-RNO-8951664); (R-RNO-9705462); (R-RNO-983168); (R-RNO-9954709)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "10213691;8202474", "class_list": "", "function": "Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. Component the von Hippel-Lindau ubiquitination complex CBC(VHL). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The ECS(ASB9) complex mediates ubiquitination and degradation of CKB. As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (By similarity). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (By similarity). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (By similarity). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63182", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0030891 VCB complex;GO:0031462 Cul2-RING ubiquitin ligase complex;GO:0031466 Cul5-RING ubiquitin ligase complex;GO:0070449 elongin complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P83941-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0PMD2-1", "uniprot_id": "ANTR1_RAT", "mass": 62319.0, "length": 562, "protein_name": "Anthrax toxin receptor 1", "gene_name": "Antxr1", "organism": "Rat", "refseq_name": "anthrax toxin receptor 1 precursor", "refseq_ac": "NP_001037714", "gene_names_uniprotkb": "Antxr1", "gene_names_refseq": "Antxr1", "protein_names_uniprotkb": "Anthrax toxin receptor 1", "protein_names_refseq": "anthrax toxin receptor 1 precursor; anthrax toxin receptor 1; tumor endothelial marker 8", "tax_id": 10116, "disease": "triple-receptor negative breast cancer (Disease Ontology:DOID:0060081); colorectal carcinoma (Disease Ontology:DOID:0080199); GAPO syndrome (Disease Ontology:DOID:0112249); breast cancer (Disease Ontology:DOID:1612); gallbladder carcinoma (Disease Ontology:DOID:4948); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:362393)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;31477767", "class_list": "", "function": "Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The role of anthrax toxin protein receptor 1 as a new mechanosensor molecule and its mechanotransduction in BMSCs under hydrostatic pressure. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0005518 collagen binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0031258 lamellipodium membrane;GO:0031527 filopodium membrane", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0001568 blood vessel development;GO:0034446 substrate adhesion-dependent cell spreading;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway;GO:1901202 negative regulation of extracellular matrix assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0PMD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47862-1", "uniprot_id": "AQP3_RAT", "mass": 31384.0, "length": 292, "protein_name": "Aquaporin-3", "gene_name": "Aqp3", "organism": "Rat", "refseq_name": "aquaporin-3", "refseq_ac": "NP_113891", "gene_names_uniprotkb": "Aqp3", "gene_names_refseq": "Aqp3", "protein_names_uniprotkb": "Aquaporin-3; 31.4 kDa water channel protein; AQP-3; Aquaglyceroporin-3", "protein_names_refseq": "31.4 kDa water channel protein; AQP-3; aquaglyceroporin-3; aquaporin-3", "tax_id": 10116, "disease": "nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); hypothyroidism (Disease Ontology:DOID:1459); brain ischemia (Disease Ontology:DOID:2316); brain edema (Disease Ontology:DOID:4724)", "pathway": " (rno:65133); (R-RNO-432040); (R-RNO-432047)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "28525373;30384362;34099798;34657253;7517548;7526388", "class_list": "", "function": "Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:7517548, PubMed:7526388). Could also be permeable to urea (PubMed:7517548, PubMed:7526388). Also participates in cell permeability to H2O2 and H2O2-mediated signaling (By similarity). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair. In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Liquid water metabolic abnormalities and intestine permeability might be the mechanism of IBS by regulating AQP1, AQP3 and AQP8 via NF-kappaB pathway., [RefSeq, PubMed]; Negative relationship between AQP-3 expression and activity of the p38 MAPK pathway in nucleus pulposus cells under oxidative damage showed that AQP-3 overexpression partly decreases the pathway's activity in nucleus pulposus cells of the same condition., [RefSeq, PubMed]; The role of AQP3 and AQP4 channels in cisplatin-induced cardiovascular edema and the protective effect of melatonin., [RefSeq, PubMed]; Unexpected localization of AQP3 and AQP4 induced by migration of primary cultured IMCD cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JPL5", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0015250 water channel activity;GO:0015254 glycerol channel activity;GO:0015166 polyol transmembrane transporter activity;GO:0015204 urea transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0002931 response to ischemia;GO:0071456 cellular response to hypoxia;GO:0032526 response to retinoic acid;GO:0042476 odontogenesis;GO:0006833 water transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P47862-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q10984-1", "uniprot_id": "FUT2_RAT", "mass": 39983.0, "length": 354, "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 2", "gene_name": "Fut2", "organism": "Rat", "refseq_name": "galactoside alpha-(1,2)-fucosyltransferase 2", "refseq_ac": "NP_113823", "gene_names_uniprotkb": "Fut2; Ftb; Sec1", "gene_names_refseq": "FTB; Ftc; Fut2; Futb", "protein_names_uniprotkb": "Galactoside alpha-(1,2)-fucosyltransferase 2; 2.4.1.344; 2.4.1.69; Alpha 1,2-fucosyltransferase B; Alpha 1,2-fucosyltransferase; Alpha 1-2 fucosyltransferase; Alpha(1,2)FT 2; Fucosyltransferase 2; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; Secretor blood group alpha-2-fucosyltransferase; Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2; Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2", "protein_names_refseq": "GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; alpha 1,2-fucosyltransferase B; alpha 1-2 fucosyltransferase; alpha 12-fucosyltransferase C; alpha(1,2)FT 2; alpha1,2-fucosyltransferase b; fucosyltransferase 2 (secretor status included); galactoside 2-alpha-L-fucosyltransferase 2; galactoside alpha-(1,2)-fucosyltransferase 2; secretor blood group alpha-2-fucosyltransferase; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2", "tax_id": 10116, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731)", "pathway": " (rno:58924); (R-RNO-9033807); (R-RNO-9037629); (R-RNO-9840309)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11179967;11341836;8010942", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:11179967, PubMed:11341836). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (By similarity). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:11179967)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35087;Q9JK44;Q9R275", "ec_number_list": "2.4.1.-;2.4.1.344;2.4.1.69", "go_molecular_function": "GO:0008417 fucosyltransferase activity;GO:0031127 alpha-(1,2)-fucosyltransferase activity;GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 1540, "hit_score": 0.4, "record_id": "Q10984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10633-1", "uniprot_id": "CP2D1_RAT", "mass": 57175.0, "length": 504, "protein_name": "Cytochrome P450 2D1", "gene_name": "Cyp2d1; Cyp2d3; Cyp2d5", "organism": "Rat", "refseq_name": "cytochrome P450 2D1", "refseq_ac": "NP_695225", "gene_names_uniprotkb": "Cyp2d1; Cyp2d3; Cyp2d5; Cyp2d-1; Cyp2d1; Cyp2d9", "gene_names_refseq": "Cyp2d1; Cyp2d9", "protein_names_uniprotkb": "Cytochrome P450 2D1; 1.14.14.1; CYPIID1; Cytochrome P450-CMF1A; Cytochrome P450-DB1; Cytochrome P450-UT-7; Debrisoquine 4-hydroxylase", "protein_names_refseq": "CYPIID1; P450-CMF1A; P450-DB1; P450-UT-7; cytochrome P450 2D1; cytochrome P450, family 2, subfamily d, polypeptide 9; cytochrome P450-CMF1A; cytochrome P450-DB1; cytochrome P450-UT-7; debrisoquine 4-hydroxylase", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:266684)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14523622;26913515;27390106;2819073;29393594;3190674;33091481;34943983;3582092;39063146;9434752", "class_list": "", "function": "CYP2D1 expression in liver is significantly impacted by blast-induced traumatic brain injury., [RefSeq, PubMed]; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms. Erratum:[Cells. 2024 Dec 23;13(24):2133. doi: 10.3390/cells13242133. PMID: 39768231] Publication Status: Online-Only, [RefSeq, PubMed]; The Effect of Maternal High-Fat or High-Carbohydrate Diet during Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the Liver and Brain of Rat Offspring. Publication Status: Online-Only, [RefSeq, PubMed]; The effect of ageing and cerebral serotonin deficit on the activity of cytochrome P450 2D (CYP2D) in the brain and liver of male rats., [RefSeq, PubMed]; There were marked differences in the degree of expression of the isoforms of P450, for example CYP2D1 was only weakly expressed in foetal ventral mesencephalon (VM) sections but expression was strong in VM cultures., [RefSeq, PubMed]; This study suggests that there is an impairment of CYP2D and CYP3A metabolism in aging rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35105;Q6AZ78", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035094 response to nicotine;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process;GO:0009410 response to xenobiotic stimulus;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P10633-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I0I9-1", "uniprot_id": "CQ10B_RAT", "mass": 27601.0, "length": 240, "protein_name": "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "gene_name": "Coq10b", "organism": "Rat", "refseq_name": "coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "refseq_ac": "NP_001009671", "gene_names_uniprotkb": "Coq10b", "gene_names_refseq": "Coq10b; RGD1359509", "protein_names_uniprotkb": "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "protein_names_refseq": "coenzyme Q-binding protein COQ10 homolog B, mitochondrial; coenzyme Q10 homolog B", "tax_id": 10116, "disease": "", "pathway": " (rno:301416); (R-RNO-611105)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17824807", "class_list": "", "function": "Administration of simvastatin under the condition of nitric oxide-deficiency reduced the level of coenzyme Q9/10 in the heart and skeletal muscle., [RefSeq, PubMed]; Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26684-1", "uniprot_id": "EDNRA_RAT", "mass": 48245.0, "length": 426, "protein_name": "Endothelin-1 receptor", "gene_name": "Ednra", "organism": "Rat", "refseq_name": "endothelin-1 receptor precursor", "refseq_ac": "NP_036682", "gene_names_uniprotkb": "Ednra", "gene_names_refseq": "ET-AR; ET-A; Ednra; Endor; Eta; RGD1559432", "protein_names_uniprotkb": "Endothelin-1 receptor; ET-AR; ET-A; Endothelin receptor type A", "protein_names_refseq": "endothelin A receptor; endothelin-1 receptor precursor; endothelin-1 receptor-like; endothelin-1 receptor", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); mandibulofacial dysostosis with alopecia (Disease Ontology:DOID:0060365); polycystic kidney disease (Disease Ontology:DOID:0080322); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); nephrotic syndrome (Disease Ontology:DOID:1184); velocardiofacial syndrome (Disease Ontology:DOID:12583); Huntington's disease (Disease Ontology:DOID:12858); impotence (Disease Ontology:DOID:1875); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:24326); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1312429;1849646;22154739;33098940;33127751;33339902;34894846;38166688", "class_list": "", "function": "Activation of ETAR and ETBR in myocardial tissue characterizes heart failure induced by experimental autoimmune myocarditis. Publication Status: Online-Only, [RefSeq, PubMed]; CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats., [RefSeq, PubMed]; Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Endothelin receptor type A is involved in the development of oxaliplatin-induced mechanical allodynia and cold allodynia acting through spinal and peripheral mechanisms in rats., [RefSeq, PubMed]; Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein-Coupled Estrogen Receptor 1., [RefSeq, PubMed]; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 20, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004962 endothelin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0030315 T-tubule", "go_biological_process": "GO:0030878 thyroid gland development;GO:1904888 cranial skeletal system development;GO:0048484 enteric nervous system development;GO:0050678 regulation of epithelial cell proliferation;GO:0086100 endothelin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P26684-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8D7-1", "uniprot_id": "F221A_RAT", "mass": 32904.0, "length": 296, "protein_name": "Protein FAM221A", "gene_name": "Fam221a", "organism": "Rat", "refseq_name": "protein FAM221A isoform 1", "refseq_ac": "NP_001020942", "gene_names_uniprotkb": "Fam221a", "gene_names_refseq": "Fam221a", "protein_names_uniprotkb": "Protein FAM221A", "protein_names_refseq": "protein FAM221A isoform 1; protein FAM221A; uncharacterized protein C7orf46 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500118)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97834-1", "uniprot_id": "CSN1_RAT", "mass": 53428.0, "length": 471, "protein_name": "COP9 signalosome complex subunit 1", "gene_name": "Gps1", "organism": "Rat", "refseq_name": "COP9 signalosome complex subunit 1 isoform 2", "refseq_ac": "NP_001257868", "gene_names_uniprotkb": "Gps1; Cops1; Csn1", "gene_names_refseq": "Gps1; MFH", "protein_names_uniprotkb": "COP9 signalosome complex subunit 1; G protein pathway suppressor 1; GPS-1; JAB1-containing signalosome subunit 1; MFH protein; SGN1; Signalosome subunit 1", "protein_names_refseq": "COP9 signalosome complex subunit 1 isoform 2; COP9 signalosome complex subunit 1; GPS-1; JAB1-containing signalosome subunit 1; SGN1; signalosome subunit 1", "tax_id": 10116, "disease": "", "pathway": " (rno:117039); (R-RNO-5696394); (R-RNO-6781823); (R-RNO-8856825); (R-RNO-8951664); (R-RNO-9013422)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "21937878;22673903;23370976;26700435;26754107;9863633", "class_list": "", "function": "Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; JAB1 promotes neuropathic pain via positively regulating JNK and NF-kappaB activation, [RefSeq, PubMed]; Jab1/CSN5, when elevated in certain tumors, may evade triggering E2F1 aopotosis through the frequent, simultaneous co-activation of PI3K activity., [RefSeq, PubMed]; Sciatic nerve crush resulted in a significant upregulation of Jab1., [RefSeq, PubMed]; VCP and Jab1 provide a novel signaling pathway for testicular ischemia and may play an important role in ischemia-reperfusion injury induced cell death in rat testis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97834-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PQL8-1", "uniprot_id": "F149B_RAT", "mass": 53218.0, "length": 482, "protein_name": "Primary cilium assembly protein FAM149B1", "gene_name": "Fam149b1", "organism": "Rat", "refseq_name": "primary cilium assembly protein FAM149B1 isoform 1", "refseq_ac": "NP_001013900", "gene_names_uniprotkb": "Fam149b1", "gene_names_refseq": "Fam149b1; RGD1359592", "protein_names_uniprotkb": "Primary cilium assembly protein FAM149B1", "protein_names_refseq": "primary cilium assembly protein FAM149B1 isoform 1; primary cilium assembly protein FAM149B1; protein FAM149B1", "tax_id": 10116, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777)", "pathway": " (rno:289900)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the localization of proteins to the cilium and cilium assembly. Indirectly regulates the signaling functions of the cilium, being required for normal SHH/smoothened signaling and proper development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "GO:0060271 cilium assembly;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BK32-1", "uniprot_id": "FAF2_RAT", "mass": 41080.0, "length": 346, "protein_name": "FAS-associated factor 2", "gene_name": "Faf2", "organism": "Rat", "refseq_name": "FAS-associated factor 2 isoform 2", "refseq_ac": "NP_001017445", "gene_names_uniprotkb": "Faf2; Ubxd8", "gene_names_refseq": "2210404d11rik; Faf2; RGD1306577; Ubxd8", "protein_names_uniprotkb": "FAS-associated factor 2; UBX domain-containing protein 8", "protein_names_refseq": "FAS-associated factor 2 isoform 2; FAS-associated factor 2; UBX domain containing 8; UBX domain-containing protein 8; protein expressed in T-cells and eosinophils in atopic dermatitis", "tax_id": 10116, "disease": "", "pathway": " (rno:291000); (R-RNO-6798695); (R-RNO-8980692)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding;GO:0055102 lipase inhibitor activity;GO:0035473 lipase binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0034389 lipid droplet organization;GO:0006986 response to unfolded protein;GO:0030970 retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QR75-1", "uniprot_id": "EXOS9_RAT", "mass": 48882.0, "length": 437, "protein_name": "Exosome complex component RRP45", "gene_name": "Exosc9", "organism": "Rat", "refseq_name": "exosome complex component RRP45", "refseq_ac": "NP_001020577", "gene_names_uniprotkb": "Exosc9", "gene_names_refseq": "Exosc9", "protein_names_uniprotkb": "Exosome complex component RRP45; Exosome component 9", "protein_names_refseq": "exosome complex component RRP45; exosome complex exonuclease RRP45", "tax_id": 10116, "disease": "pontocerebellar hypoplasia type 1D (Disease Ontology:DOID:0112323)", "pathway": " (rno:294975); (R-RNO-429958); (R-RNO-450385); (R-RNO-450513); (R-RNO-450604); (R-RNO-6791226); (R-RNO-9930044)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0006396 RNA processing;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4QR75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15684-1", "uniprot_id": "AMPN_RAT", "mass": 109449.0, "length": 965, "protein_name": "Aminopeptidase N", "gene_name": "Anpep", "organism": "Rat", "refseq_name": "aminopeptidase N precursor", "refseq_ac": "NP_112274", "gene_names_uniprotkb": "Anpep", "gene_names_refseq": "AP-M; AP-N; Anpep; Apm; Apn; KZP; Lap1; rAPN", "protein_names_uniprotkb": "Aminopeptidase N; 3.4.11.2; AP-M; AP-N; Alanyl aminopeptidase; Aminopeptidase M; KZP; Kidney Zn peptidase; Microsomal aminopeptidase; rAPN", "protein_names_refseq": "alanyl (membrane) aminopeptidase; aminopeptidase M; aminopeptidase N precursor; aminopeptidase N; cluster of differentiation antigen 13 (CD13); kidney Zn peptidase; kidney aminopeptidase M; leucine arylaminopeptidase 1; membrane alanine aminopeptidase; microsomal aminopeptidase", "tax_id": 10116, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945); malignant astrocytoma (Disease Ontology:DOID:3069)", "pathway": " (rno:81641); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11672613;1673322;2564389;2567164;26449746;30531704;36765308", "class_list": "", "function": "Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data indicate that fluorogenic substrates can be successfully used to identify aminopeptidase N and to measure their activity in cell lysates., [RefSeq, PubMed]; In standard light/dark conditions, the results demonstrated an opposite daily rhythm in hypothalamus and pituitary. While the highest levels of AlaAP or enkephalinase activities were measured in hypothalamus during the dark period, they were the highest in the pituitary during the light one., [RefSeq, PubMed]; The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHP4", "ec_number_list": "3.6.5.2;3.1.3.48;3.4.24.11;3.4.11.-;3.4.11.2;3.6.1.-;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0042277 peptide binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0072237 metanephric proximal tubule development;GO:0001525 angiogenesis;GO:0016485 protein processing;GO:0030154 cell differentiation;GO:0002003 angiotensin maturation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P15684-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M7T1-1", "uniprot_id": "CIAO1_RAT", "mass": 37618.0, "length": 339, "protein_name": "Probable cytosolic iron-sulfur protein assembly protein CIAO1", "gene_name": "Ciao1", "organism": "Rat", "refseq_name": "probable cytosolic iron-sulfur protein assembly protein CIAO1", "refseq_ac": "NP_001008766", "gene_names_uniprotkb": "Ciao1; CIAO1; Wdr39", "gene_names_refseq": "Ciao1; Wdr39", "protein_names_uniprotkb": "Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39", "protein_names_refseq": "WD repeat domain 39; WD repeat-containing protein 39; WD40 protein Ciao1; cytosolic iron-sulfur protein assembly 1; probable cytosolic iron-sulfur protein assembly protein CIAO1", "tax_id": 10116, "disease": "", "pathway": " (rno:29231)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005737 cytoplasm;GO:0071817 MMXD complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0007059 chromosome segregation;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02651-1", "uniprot_id": "APOA4_RAT", "mass": 44456.0, "length": 391, "protein_name": "Apolipoprotein A-IV", "gene_name": "Apoa4", "organism": "Rat", "refseq_name": "apolipoprotein A-IV precursor", "refseq_ac": "NP_036869", "gene_names_uniprotkb": "Apoa4", "gene_names_refseq": "Apo-AIV; ApoA-IV; Apoa4; apoAIV", "protein_names_uniprotkb": "Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4", "protein_names_refseq": "apolipoprotein A-IV precursor; apolipoprotein A-IV", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); colitis (Disease Ontology:DOID:0060180); autosomal dominant tubulointerstitial kidney disease 6 (Disease Ontology:DOID:0061121); graft-versus-host disease (Disease Ontology:DOID:0081267); Alzheimer's disease (Disease Ontology:DOID:10652); Guillain-Barre syndrome (Disease Ontology:DOID:12842); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); polyneuropathy (Disease Ontology:DOID:1389); major depressive disorder (Disease Ontology:DOID:1470); glaucoma (Disease Ontology:DOID:1686); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); retinal detachment (Disease Ontology:DOID:5327); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); rheumatoid arthritis (Disease Ontology:DOID:7148); chronic kidney disease (Disease Ontology:DOID:784); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (rno:25080); (R-RNO-8963888); (R-RNO-8963901); (R-RNO-975634)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "22673903;29037812;29393594;3009456;3020028;33322656;6591177", "class_list": "", "function": "Demonstrate a critical role of the PI3K/Akt pathway in apoA-IV's anorectic action in lean rats and suggest a defective PI3K pathway in the ventromedial hypothalamus is responsible for the impaired apoA-IV's anorectic action in the diet-induced obese animals, [RefSeq, PubMed]; Estradiol Enhances Anorectic Effect of Apolipoprotein A-IV through ERalpha-PI3K Pathway in the Nucleus Tractus Solitarius. Publication Status: Online-Only, [RefSeq, PubMed]; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BK92", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008289 lipid binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0034364 high-density lipoprotein particle;GO:0045202 synapse;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0010898 positive regulation of triglyceride catabolic process;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P02651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P86173-1", "uniprot_id": "ACL6B_RAT", "mass": 46891.0, "length": 426, "protein_name": "Actin-like protein 6B", "gene_name": "Actl6b", "organism": "Rat", "refseq_name": "actin-like protein 6B", "refseq_ac": "NP_001099387", "gene_names_uniprotkb": "Actl6b", "gene_names_refseq": "Actl6b; Actl6", "protein_names_uniprotkb": "Actin-like protein 6B; BAF53B; BRG1-associated factor 53B", "protein_names_refseq": "BAF53B; BRG1-associated factor 53B; actin-like 6; actin-like protein 6B", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 76 (Disease Ontology:DOID:0112212); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:288563); (R-RNO-3214858); (R-RNO-8939243)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "12368262", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Essential for neuronal maturation and dendrite development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6J021", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016514 SWI/SNF complex;GO:0035267 NuA4 histone acetyltransferase complex;GO:0071565 nBAF complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0016358 dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P86173-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QJV7-1", "uniprot_id": "ERR1_RAT", "mass": 45464.0, "length": 422, "protein_name": "Steroid hormone receptor ERR1", "gene_name": "Esrra", "organism": "Rat", "refseq_name": "steroid hormone receptor ERR1", "refseq_ac": "NP_001008511", "gene_names_uniprotkb": "Esrra; Nr3b1", "gene_names_refseq": "ERRalpha; Errra; Esrra", "protein_names_uniprotkb": "Steroid hormone receptor ERR1; ERR-alpha; Estrogen-related receptor alpha; Nuclear receptor subfamily 3 group B member 1", "protein_names_refseq": "ERR-alpha; nuclear receptor subfamily 3 group B member 1; orphan nuclear receptor; steroid hormone receptor ERR1", "tax_id": 10116, "disease": "azoospermia (Disease Ontology:DOID:14227); cancer (Disease Ontology:DOID:162); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:293701); (R-RNO-383280)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12193582;14614214;22673903;23517027;34403090;37340376;38677116", "class_list": "", "function": "Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle., [UniProtKB, UniProtKB, UniProtKB]; ERRalpha protects against sepsis-induced acute lung injury in rats. Publication Status: Online-Only, [RefSeq, PubMed]; ERRalpha-mediated protection of mitochondrial bioenergetics might be the likely candidate required for lung adaptation to hypobaric hypoxia, [RefSeq, PubMed]; ERalpha and ERbeta mRNA expressions are differentially regulated in rat uterus. During spontaneous labor ERalpha may play more prominent role than ERbeta in mediating estrogen action in tinduction of uterine oxytocin receptor mRNA before labor., [RefSeq, PubMed]; Estrogen receptor-related receptor alpha (ERRalpha) is regulated by estrogen in bone in which it may play a functional role at several levels in E2 deficiency diseases such as osteoporosis., [RefSeq, PubMed]; Molecular Mediators of Estrogen Reduction-induced Otolith Shedding., [RefSeq, PubMed]; ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1alpha/ERRalpha axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHT1", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0003707 nuclear steroid receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0000785 chromatin", "go_biological_process": "GO:1900078 positive regulation of cellular response to insulin stimulus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5QJV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QQV3-1", "uniprot_id": "F162A_RAT", "mass": 17827.0, "length": 155, "protein_name": "Protein FAM162A", "gene_name": "Fam162a", "organism": "Rat", "refseq_name": "protein FAM162A", "refseq_ac": "NP_001386205", "gene_names_uniprotkb": "Fam162a; E2ig5", "gene_names_refseq": "Fam162a", "protein_names_uniprotkb": "Protein FAM162A; E2-induced gene 5 protein homolog", "protein_names_refseq": "E2-induced gene 5 protein homolog; growth and transformation-dependent protein; protein FAM162A", "tax_id": 10116, "disease": "", "pathway": " (rno:360721)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19520982;26446791", "class_list": "", "function": "Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process;GO:0071456 cellular response to hypoxia;GO:0090200 positive regulation of release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4QQV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BK24-1", "uniprot_id": "CH076_RAT", "mass": 41801.0, "length": 374, "protein_name": "Uncharacterized protein C8orf76 homolog", "gene_name": "C7h8orf76", "organism": "Rat", "refseq_name": "uncharacterized protein C8orf76 homolog", "refseq_ac": "NP_001020178", "gene_names_uniprotkb": "C7h8orf76; RGD1310852", "gene_names_refseq": "C7h8orf76; RGD1310852", "protein_names_uniprotkb": "Uncharacterized protein C8orf76 homolog", "protein_names_refseq": "uncharacterized protein C8orf76 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:314992)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11711-1", "uniprot_id": "CP2A1_RAT", "mass": 55995.0, "length": 492, "protein_name": "Cytochrome P450 2A1", "gene_name": "Cyp2a1; Cyp2a2; Cyp2a3", "organism": "Rat", "refseq_name": "cytochrome P450 2A1", "refseq_ac": "NP_036824", "gene_names_uniprotkb": "Cyp2a1; Cyp2a2; Cyp2a3; Cyp2a-1; Cyp2a1; Cyp2a3", "gene_names_refseq": "Cyp2a1; RATCYP2A1; Shdl", "protein_names_uniprotkb": "Cytochrome P450 2A1; 1.14.14.1; CYPIIA1; Cytochrome P450-UT-F; Steroid hormones 7-alpha-hydroxylase; Testosterone 7-alpha-hydroxylase", "protein_names_refseq": "CYPIIA1; P450-UT-F; cytochrome P450 2A1; cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1); cytochrome P450-UT-F; steroid hormones 7-alpha-hydroxylase; steroid hydroxylase, hepatic; testosterone 7-alpha-hydroxylase", "tax_id": 10116, "disease": "", "pathway": " (rno:24894); (R-RNO-211935); (R-RNO-211981); (R-RNO-211999); (R-RNO-5423646)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12162851;22217848;22673903;2322568;2650624;3436956;3818621", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that structures of active sites of CYP2A1 and CYP2A2 have certain amount of flexibility and that non-specific binding (i.e., hydrophobic binding) is involved in differences in substrate specificity between these two enzymes., [RefSeq, PubMed]; Highly active in the 7-alpha-hydroxylation of testosterone, progesterone and androstenedione., [UniProtKB]; The rat orthologue (CYP2A1) exhibits 3,4-epoxidation of coumarin, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q642C5", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway;GO:0009804 coumarin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P11711-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3MIE0-1", "uniprot_id": "ECHD3_RAT", "mass": 32385.0, "length": 300, "protein_name": "Enoyl-CoA hydratase domain-containing protein 3, mitochondrial", "gene_name": "Echdc3", "organism": "Rat", "refseq_name": "enoyl-CoA hydratase domain-containing protein 3, mitochondrial precursor", "refseq_ac": "NP_001094480", "gene_names_uniprotkb": "Echdc3", "gene_names_refseq": "Echdc3", "protein_names_uniprotkb": "Enoyl-CoA hydratase domain-containing protein 3, mitochondrial", "protein_names_refseq": "enoyl Coenzyme A hydratase domain containing 3; enoyl-CoA hydratase domain-containing protein 3, mitochondrial precursor; enoyl-CoA hydratase domain-containing protein 3, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:684538)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in fatty acid biosynthesis and insulin sensitivity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004300 enoyl-CoA hydratase activity;GO:0016836 hydro-lyase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:1900078 positive regulation of cellular response to insulin stimulus;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MIE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06211-1", "uniprot_id": "ESR1_RAT", "mass": 67030.0, "length": 600, "protein_name": "Estrogen receptor", "gene_name": "Esr1", "organism": "Rat", "refseq_name": "estrogen receptor", "refseq_ac": "NP_036821", "gene_names_uniprotkb": "Esr1; Esr; Estr; Nr3a1", "gene_names_refseq": "ER-alpha; Esr1; Esr; RNESTROR", "protein_names_uniprotkb": "Estrogen receptor; ER-alpha; ER; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1", "protein_names_refseq": "C-terminally-truncated estrogen receptor alpha product-1; Er alpha; estradiol receptor; estrogen receptor 1 (alpha); estrogen receptor alpha i45aL; estrogen receptor alpha i45aS; estrogen receptor alpha i45c; estrogen receptor alpha i56a; estrogen receptor alpha i56b; estrogen receptor alpha i56c; estrogen receptor alpha i56dL; estrogen receptor alpha i56dS; estrogen receptor alpha i56e; estrogen receptor alpha variant delta 4; estrogen receptor protein; estrogen receptor; nuclear receptor subfamily 3 group A member 1; trunctaed estrogen receptor product-1", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); prostatic hypertrophy (Disease Ontology:DOID:11132); cryptorchidism (Disease Ontology:DOID:11383); osteoporosis (Disease Ontology:DOID:11476); vitiligo (Disease Ontology:DOID:12306); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); Leydig cell tumor (Disease Ontology:DOID:2696); endometriosis (Disease Ontology:DOID:289); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); infertility (Disease Ontology:DOID:5223); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); sporadic breast cancer (Disease Ontology:DOID:8029); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); prostate carcinoma in situ (Disease Ontology:DOID:8634); in situ carcinoma (Disease Ontology:DOID:8719); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24890); (R-RNO-1251985); (R-RNO-1257604); (R-RNO-383280); (R-RNO-4090294); (R-RNO-5689896); (R-RNO-6811558); (R-RNO-8866910); (R-RNO-8931987); (R-RNO-8939211); (R-RNO-9009391); (R-RNO-9018519); (R-RNO-9841251)", "pathway_count": 13, "publication_count": 10, "publication_id_list": "11818503;17658481;19423554;21808025;3031601;37595756;37914358;38029582;38713613;39138001", "class_list": "", "function": "Decrease in ERa within the BNST of sexually naive male rats following an encounter with a novel female., [RefSeq, PubMed]; Effect of estrogen receptor alpha on cardiopulmonary adaptation to chronic developmental hypoxia in a rat model., [RefSeq, PubMed]; Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis., [RefSeq, PubMed]; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (PubMed:21808025)., [UniProtKB, PubMed]; Synergistic effects of T-2 toxin and selenium deficiency exacerbate renal fibrosis through modulation of the ERalpha/PI3K/Akt signaling pathway., [RefSeq, PubMed]; The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male-But Not Female-Rats to Enhance Short-Term Memory. Publication Status: Online-Only, [RefSeq, PubMed]; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031798 type 1 metabotropic glutamate receptor binding;GO:0001093 TFIIB-class transcription factor binding;GO:0034056 estrogen response element binding;GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043195 terminal bouton", "go_biological_process": "GO:0001547 antral ovarian follicle growth;GO:0060523 prostate epithelial cord elongation;GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0060745 mammary gland branching involved in pregnancy;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P06211-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28037-1", "uniprot_id": "AL1L1_RAT", "mass": 98874.0, "length": 902, "protein_name": "Cytosolic 10-formyltetrahydrofolate dehydrogenase", "gene_name": "Aldh1l1", "organism": "Rat", "refseq_name": "cytosolic 10-formyltetrahydrofolate dehydrogenase", "refseq_ac": "NP_071992", "gene_names_uniprotkb": "Aldh1l1; Fthfd", "gene_names_refseq": "Aldh1l1; FDH; Fthfd", "protein_names_uniprotkb": "Cytosolic 10-formyltetrahydrofolate dehydrogenase; 1.5.1.6; 10-FTHFDH; Aldehyde dehydrogenase family 1 member L1; FBP-CI; FDH", "protein_names_refseq": "10-FTHFDH; 10-formyltetrahydrofolate dehydrogenase; FBP-CI; aldehyde dehydrogenase family 1 member L1; cytosolic 10-formyltetrahydrofolate dehydrogenase", "tax_id": 10116, "disease": "cholestasis (Disease Ontology:DOID:13580)", "pathway": " (rno:64392); (R-RNO-196757)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10585460;14729668;16396499;17302434;17884809;1848231;21540484;22673903;3392008;35013550;36675153;7822273", "class_list": "", "function": "A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements. Publication Status: Online-Only, [RefSeq, PubMed]; Catalytic mechanism for the hydrolase reaction in which Asp-142 polarizes the catalytic water molecule and His-106 orients the carbonyl group of formyl., [RefSeq, PubMed]; Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:10585460, PubMed:17302434, PubMed:17884809, PubMed:1848231, PubMed:7822273). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (PubMed:1848231)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Structure of putative tumor suppressor ALDH1L1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5HZB2", "ec_number_list": "1.5.1.6", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity;GO:0016155 formyltetrahydrofolate dehydrogenase activity;GO:0033721 aldehyde dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0009258 10-formyltetrahydrofolate catabolic process;GO:0046655 folic acid metabolic process;GO:0006740 NADPH regeneration;GO:0035999 tetrahydrofolate interconversion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P28037-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26819-1", "uniprot_id": "GRK3_RAT", "mass": 79887.0, "length": 688, "protein_name": "G protein-coupled receptor kinase 3", "gene_name": "Grk3", "organism": "Rat", "refseq_name": "G protein-coupled receptor kinase 3", "refseq_ac": "NP_037029", "gene_names_uniprotkb": "Grk3; Adrbk2", "gene_names_refseq": "Adrbk2; Grk3", "protein_names_uniprotkb": "G protein-coupled receptor kinase 3; 2.7.11.15; 2.7.11.16; Beta-ARK-2; Beta-adrenergic receptor kinase 2", "protein_names_refseq": "G protein-coupled receptor kinase 3; adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase); adrenergic, beta, receptor kinase 2; beta ARK2; beta-ARK-2; beta-adrenergic receptor kinase 2", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); bipolar disorder (Disease Ontology:DOID:3312); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:25372); (R-RNO-418555); (R-RNO-8856825)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1403099;23935208;26043205;9826657", "class_list": "", "function": "Our findings reveal a novel mechanism of GRK3 control of the dopamine receptor signaling and the role of Gq in LID. Publication Status: Online-Only, [RefSeq, PubMed]; Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:1403099). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:1403099). Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors (PubMed:1403099). Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (By similarity). Positively regulates ciliary smoothened (SMO) signaling pathway by mediating phosphorylation of SMO, facilitating SMO trafficking into the cilium and the stimulation of SMO activity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The loss of GRK3-mediated regulation of CXCL12/CXCR4 signaling contributes to some, but not all, of the complete WHIM phenotype and that GRK3 inhibition may be beneficial in the treatment of inflammatory arthritis., [RefSeq, PubMed]; receptors. Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.-;2.7.11.15;2.7.11.16", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0001664 G protein-coupled receptor binding;GO:0004703 G protein-coupled receptor kinase activity;GO:0047696 beta-adrenergic receptor kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0043198 dendritic shaft", "go_biological_process": "GO:0046154 rhodopsin metabolic process;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0006886 intracellular protein transport;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P26819-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QE79-1", "uniprot_id": "AOXD_RAT", "mass": 147841.0, "length": 1334, "protein_name": "Aldehyde oxidase 4", "gene_name": "Aox3; Aox4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Aox3; Aox4; Aoh2; Aox4", "gene_names_refseq": "", "protein_names_uniprotkb": "Aldehyde oxidase 4; 1.17.3.-; 1.2.3.1; Aldehyde oxidase homolog 2; Azaheterocycle hydroxylase 4; Retinal oxidase", "protein_names_refseq": "", "tax_id": 10116, "disease": "xanthinuria (Disease Ontology:DOID:0060236)", "pathway": " (rno:316424); (rno:493909)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15383531;22673903;23263164", "class_list": "", "function": "Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.17.3.-;1.2.3.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0004031 aldehyde oxidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5QE79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C279-1", "uniprot_id": "CPEB1_RAT", "mass": 62062.0, "length": 561, "protein_name": "Cytoplasmic polyadenylation element-binding protein 1", "gene_name": "Cpeb1", "organism": "Rat", "refseq_name": "cytoplasmic polyadenylation element-binding protein 1 isoform 4", "refseq_ac": "NP_001099746", "gene_names_uniprotkb": "Cpeb1", "gene_names_refseq": "Cpeb1", "protein_names_uniprotkb": "Cytoplasmic polyadenylation element-binding protein 1; CPE-BP1; CPE-binding protein 1; CPEB-1; CPEB", "protein_names_refseq": "CPE-BP1; CPE-binding protein 1; CPEB-1; CPEB; cytoplasmic polyadenylation element-binding protein 1 isoform 4", "tax_id": 10116, "disease": "portal hypertension (Disease Ontology:DOID:10762); primary biliary cholangitis (Disease Ontology:DOID:12236); glioblastoma (Disease Ontology:DOID:3068); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:293056)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23824559;26627607;31253357;38616716;9856468", "class_list": "", "function": "CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa cells of polycystic ovary syndrome., [RefSeq, PubMed]; Cytoplasmic polyadenylation element-binding proteins (CPEB) are mRNA-binding proteins associated with protein translation that play an important role in development, health, and disease., [RefSeq, PubMed]; Identify a mechanism of VEGF overexpression in liver and mesentery that promotes pathologic, but not physiologic, angiogenesis, via sequential and nonredundant functions of CPEB1 and CPEB4., [RefSeq, PubMed]; Increased NPCs proliferation by down-regulation of CPEB1 resulted in eventual up-regulation of neuronal differentiation with increase in both pre- and post-synaptic proteins, [RefSeq, PubMed]; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0046872 metal ion binding;GO:0008135 translation factor activity, RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0008285 negative regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C279-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23965-1", "uniprot_id": "ECI1_RAT", "mass": 32254.0, "length": 289, "protein_name": "Enoyl-CoA delta isomerase 1, mitochondrial", "gene_name": "Eci1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Eci1; Dci", "gene_names_refseq": "", "protein_names_uniprotkb": "Enoyl-CoA delta isomerase 1, mitochondrial; 3,2-trans-enoyl-CoA isomerase; 5.3.3.8; D3,D2-enoyl-CoA isomerase; Delta(3),Delta(2)-enoyl-CoA isomerase; Dodecenoyl-CoA isomerase; MECI", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:29740); (R-RNO-77288); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11781327;15883186;1958319;2040594;29393594;8218206", "class_list": "", "function": "Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids (PubMed:11781327, PubMed:8218206). Together with the 2,4-dienoyl-CoA reductase (DECR) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH1), they allow the reentrance of the enoyl-CoA into the beta-oxidation cycle. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of fatty enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs (PubMed:11781327, PubMed:8218206). The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length, and based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (Probable)., [UniProtKB, PubMed, PubMed]; Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.5;1.3.8.5;6.2.1.4;4.98.1.1;5.6.2.3;2.8.3.5;2.3.1.-;2.3.1.41;3.4.21.92;3.5.3.1;3.1.2.2;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.2.-;1.1.1.37;6.4.1.3;4.2.1.17;5.3.3.8;7.1.2.2;1.4.1.3;1.2.1.3;2.3.1.37;4.2.1.2;2.3.1.9;2.3.3.10;1.1.1.30;3.6.4.10;1.2.4.1;1.1.1.42;5.6.1.7;1.3.8.1;2.7.1.23;1.2.4.2;5.3.3.21;2.7.11.2;2.7.11.-;7.1.1.2;1.2.1.36;1.7.1.-;1.2.1.28;1.8.1.4;2.3.3.1;3.4.21.53;1.1.1.41;4.2.1.3", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity;GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P23965-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52303-1", "uniprot_id": "AP1B1_RAT", "mass": 104589.0, "length": 949, "protein_name": "AP-1 complex subunit beta-1", "gene_name": "Ap1b1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ap1b1; Adtb1", "gene_names_refseq": "", "protein_names_uniprotkb": "AP-1 complex subunit beta-1; Adaptor protein complex AP-1 subunit beta-1; Adaptor-related protein complex 1 subunit beta-1; Beta-1-adaptin; Beta-adaptin 1; Clathrin assembly protein complex 1 beta large chain; Golgi adaptor HA1/AP1 adaptin beta subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); alcohol use disorder (Disease Ontology:DOID:1574); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:29663); (R-RNO-2132295); (R-RNO-432720); (R-RNO-432722)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "15377783;2495531;38843836;7987321", "class_list": "", "function": "Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030276 clathrin binding;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0030118 clathrin coat;GO:0005794 Golgi apparatus;GO:0030665 clathrin-coated vesicle membrane;GO:0030131 clathrin adaptor complex;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007507 heart development;GO:0001822 kidney development;GO:0016192 vesicle-mediated transport;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P52303-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60711-1", "uniprot_id": "ACTB_RAT", "mass": 41737.0, "length": 375, "protein_name": "Actin, cytoplasmic 1", "gene_name": "Actb; Actg1", "organism": "Rat", "refseq_name": "actin, cytoplasmic 1", "refseq_ac": "NP_112406", "gene_names_uniprotkb": "Actb; Actg1; Actg1l1; LOC100361457", "gene_names_refseq": "Actb; Actx", "protein_names_uniprotkb": "Actin, cytoplasmic 1; 3.6.4.-; Beta-actin", "protein_names_refseq": "actin, cytoplasmic 1; beta-actin; cytoplasmic beta-actin", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); Baraitser-Winter syndrome 2 (Disease Ontology:DOID:0081113); hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); hand, foot and mouth disease (Disease Ontology:DOID:10881); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); thrombocytopenia (Disease Ontology:DOID:1588); nemaline myopathy (Disease Ontology:DOID:3191); temporal lobe epilepsy (Disease Ontology:DOID:3328); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:81822); (R-RNO-190873); (R-RNO-196025); (R-RNO-2029482); (R-RNO-3928662); (R-RNO-418990); (R-RNO-437239); (R-RNO-4420097); (R-RNO-445095); (R-RNO-446353); (R-RNO-5626467); (R-RNO-5663213); (R-RNO-5663220); (R-RNO-5674135); (R-RNO-8856828); (R-RNO-9013418); (R-RNO-9764561); (R-RNO-9913351); (R-RNO-9953170); (R-RNO-9958825)", "pathway_count": 20, "publication_count": 9, "publication_id_list": "18683930;21933451;30526847;30659401;31566433;32574643;34502162;38843836;6300777", "class_list": "", "function": "Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (By similarity). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (By similarity). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P02570;P70514;P99021;Q11211;Q64316", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;2.3.2.31;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;2.7.10.1;3.6.5.2;3.6.5.-;5.6.2.-;2.3.2.26;3.1.-.-;3.1.3.86;3.1.3.56;3.1.3.36;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.5.5;2.7.11.24;3.6.1.-;2.7.10.4;2.7.12.2;2.7.4.3;3.1.4.-;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5;2.7.10.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0019894 kinesin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0098871 postsynaptic actin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007409 axonogenesis;GO:0007010 cytoskeleton organization;GO:0009612 response to mechanical stimulus;GO:0060041 retina development in camera-type eye;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P60711-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BK84-1", "uniprot_id": "ADAM5_RAT", "mass": 79907.0, "length": 709, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 5", "gene_name": "Adam5", "organism": "Rat", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 5 isoform 3", "refseq_ac": "NP_064699", "gene_names_uniprotkb": "Adam5; Tmdc2", "gene_names_refseq": "Adam5; tMDCII", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 5; Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II; tMDC II", "protein_names_refseq": "a disintegrin and metallopeptidase domain 5; a disintegrin and metalloprotease domain (ADAM) 5; a disintegrin and metalloprotease domain 5; disintegrin and metalloproteinase domain-containing protein 5 isoform 3; disintegrin and metalloproteinase domain-containing protein 5; tMDC II; transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II", "tax_id": 10116, "disease": "", "pathway": " (rno:498654)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9291465", "class_list": "", "function": "This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NDL0-1", "uniprot_id": "EOGT_RAT", "mass": 61524.0, "length": 527, "protein_name": "EGF domain-specific O-linked N-acetylglucosamine transferase", "gene_name": "Eogt", "organism": "Rat", "refseq_name": "EGF domain-specific O-linked N-acetylglucosamine transferase isoform 4 precursor", "refseq_ac": "NP_001009502", "gene_names_uniprotkb": "Eogt; Aer61", "gene_names_refseq": "Aer61; Eogt", "protein_names_uniprotkb": "EGF domain-specific O-linked N-acetylglucosamine transferase; 2.4.1.255; Extracellular O-linked N-acetylglucosamine transferase", "protein_names_refseq": "EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase; EGF domain-specific O-linked N-acetylglucosamine transferase isoform 4 precursor; extracellular O-linked N-acetylglucosamine transferase; glycosyltransferase Aer61", "tax_id": 10116, "disease": "Adams-Oliver syndrome (Disease Ontology:DOID:0060227)", "pathway": " (rno:494219)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.255", "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 5, "hit_score": 0.1, "record_id": "Q5NDL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVC7-1", "uniprot_id": "ACAP2_RAT", "mass": 87230.0, "length": 770, "protein_name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2", "gene_name": "Acap2", "organism": "Rat", "refseq_name": "arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2", "refseq_ac": "NP_001029178", "gene_names_uniprotkb": "Acap2; Centb2", "gene_names_refseq": "Acap2; Centb2; cnt-b2", "protein_names_uniprotkb": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; Centaurin-beta-2; Cnt-b2", "protein_names_refseq": "arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; centaurin-beta-2", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:619382)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22344257;22673903;23572513;24600047;25694427", "class_list": "", "function": "GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; GTPase-activating protein for the ADP ribosylation factor family., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rab35 regulates Arf6 activity through centaurin-beta2 (ACAP2) during neurite outgrowth., [RefSeq, PubMed]; Rab35/ACAP2 and cytohesin-2 antagonistically control oligodendrocyte differentiation and myelination through Arf6 regulation., [RefSeq, PubMed]; Showed by knockdown-rescue approaches that neither a centaurin-beta2 binding-deficient Rab35(T76S/T81A) mutant nor a Rab35 binding-deficient centaurin-beta2(N610A/N691A) mutant supported neurite outgrowth of PC12 cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0001726 ruffle", "go_biological_process": "GO:1990090 cellular response to nerve growth factor stimulus;GO:0032456 endocytic recycling;GO:0030029 actin filament-based process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5FVC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63155-1", "uniprot_id": "CRNL1_RAT", "mass": 83416.0, "length": 690, "protein_name": "Crooked neck-like protein 1", "gene_name": "Crnkl1", "organism": "Rat", "refseq_name": "crooked neck-like protein 1", "refseq_ac": "NP_446249", "gene_names_uniprotkb": "Crnkl1; Crn; LOC102548514", "gene_names_refseq": "Crnkl1; Crn", "protein_names_uniprotkb": "Crooked neck-like protein 1; Crooked neck homolog; Crooked neck protein", "protein_names_refseq": "Crn, crooked neck-like 1; crooked neck homolog; crooked neck pre-mRNA splicing factor-like 1; crooked neck-like 1 protein-like; crooked neck-like protein 1-like; crooked neck-like protein 1", "tax_id": 10116, "disease": "basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (rno:100910202); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12801913", "class_list": "", "function": "Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication., [UniProtKB, UniProtKB]; Involved in pre-mRNA splicing process. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQC1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0021987 cerebral cortex development;GO:1990830 cellular response to leukemia inhibitory factor;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63155-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05182-1", "uniprot_id": "CP2E1_RAT", "mass": 56627.0, "length": 493, "protein_name": "Cytochrome P450 2E1", "gene_name": "Cyp2e1", "organism": "Rat", "refseq_name": "cytochrome P450 2E1", "refseq_ac": "NP_113731", "gene_names_uniprotkb": "Cyp2e1; Cyp2e-1; Cyp2e", "gene_names_refseq": "Cyp2e1; Cyp2e", "protein_names_uniprotkb": "Cytochrome P450 2E1; 1.14.13.n7; 1.14.14.1; 4-nitrophenol 2-hydroxylase; CYPIIE1; Cytochrome P450-J; Cytochrome P450RLM6", "protein_names_refseq": "4-nitrophenol 2-hydroxylase; CYPIIE1; P450-J; P450RLM6; cytochrome P450 2E1; cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450-J; cytochrome P450RLM6", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hepatocellular adenoma (Disease Ontology:DOID:0050868); left ventricular failure (Disease Ontology:DOID:0051064); CST3-related cerebral amyloid angiopathy (Disease Ontology:DOID:0070027); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); age related macular degeneration 11 (Disease Ontology:DOID:0110023); asbestosis (Disease Ontology:DOID:10320); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); intracranial aneurysm (Disease Ontology:DOID:10941); familial hyperlipidemia (Disease Ontology:DOID:1168); iron deficiency anemia (Disease Ontology:DOID:11758); morbid obesity (Disease Ontology:DOID:11981); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); acoustic neuroma (Disease Ontology:DOID:12689); Guillain-Barre syndrome (Disease Ontology:DOID:12842); polyneuropathy (Disease Ontology:DOID:1389); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); drug-induced hepatitis (Disease Ontology:DOID:2044); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); peripheral vascular disease (Disease Ontology:DOID:341); middle cerebral artery infarction (Disease Ontology:DOID:3525); liver disease (Disease Ontology:DOID:409); pneumonia (Disease Ontology:DOID:552); kidney disease (Disease Ontology:DOID:557); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); extrinsic allergic alveolitis (Disease Ontology:DOID:841); oral cavity cancer (Disease Ontology:DOID:8618); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25086); (R-RNO-211981); (R-RNO-211999); (R-RNO-9027307); (R-RNO-9749641); (R-RNO-9753281)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "12191992;1441586;19401463;2321956;2832413;3308889;35523980;35780828;37195324;37499993;37657698;3782137", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Adverse outcome pathway exploration of furan-induced liver fibrosis in rats: Genotoxicity pathway or oxidative stress pathway through CYP2E1 activation?, [RefSeq, PubMed]; CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma., [RefSeq, PubMed]; Cyp2e1 knockdown attenuates high glucose-induced apoptosis and oxidative stress of cardiomyocytes by activating PI3K/Akt signaling., [RefSeq, PubMed]; Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure., [RefSeq, PubMed]; Cytochrome P450 2E1 predicts liver functional recovery from donation after circulatory death using air-ventilated normothermic machine perfusion. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 48, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;1.14.14.80", "go_molecular_function": "GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002933 lipid hydroxylation;GO:0016098 monoterpenoid metabolic process;GO:1904681 response to 3-methylcholanthrene;GO:0001676 long-chain fatty acid metabolic process;GO:0006641 triglyceride metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P05182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVQ7-1", "uniprot_id": "F174A_RAT", "mass": 20228.0, "length": 190, "protein_name": "Membrane protein FAM174A", "gene_name": "Fam174a", "organism": "Rat", "refseq_name": "membrane protein FAM174A precursor", "refseq_ac": "NP_001012350", "gene_names_uniprotkb": "Fam174a; Tmem157", "gene_names_refseq": "Fam174a; Fam174; RGD1309973; Tmem157", "protein_names_uniprotkb": "Membrane protein FAM174A; Transmembrane protein 157", "protein_names_refseq": "membrane protein FAM174A precursor; membrane protein FAM174A; transmembrane protein 157", "tax_id": 10116, "disease": "", "pathway": " (rno:301634)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I0K7-1", "uniprot_id": "ALG13_RAT", "mass": 18329.0, "length": 165, "protein_name": "UDP-N-acetylglucosamine transferase subunit ALG13", "gene_name": "Alg13", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Alg13", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-N-acetylglucosamine transferase subunit ALG13; 2.4.1.141; Asparagine-linked glycosylation 13 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 36 (Disease Ontology:DOID:0080470)", "pathway": " (rno:300284); (R-RNO-446193)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway., [UniProtKB, UniProtKB]; No glycosyltransferase or deubiquitinase activity is detected for this potential multifunctional enzyme., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.141;3.4.19.12", "go_molecular_function": "GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0043541 UDP-N-acetylglucosamine transferase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0006508 proteolysis;GO:0048167 regulation of synaptic plasticity;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 15150, "hit_score": 0.1, "record_id": "Q5I0K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20651-1", "uniprot_id": "PP2BB_RAT", "mass": 59113.0, "length": 525, "protein_name": "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform", "gene_name": "Ppp3cb", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 2B catalytic subunit beta isoform", "refseq_ac": "NP_058738", "gene_names_uniprotkb": "Ppp3cb", "gene_names_refseq": "Calna2; Ppp3cb", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; 3.1.3.16; CAM-PRP catalytic subunit; CNA beta; Calmodulin-dependent calcineurin A subunit beta isoform", "protein_names_refseq": "CAM-PRP catalytic subunit; CNA beta; CaN Abeta; Calcineurin subunit A beta; protein phosphatase 3, catalytic subunit, beta isozyme; protein phosphatase-2Bb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); aortic valve stenosis (Disease Ontology:DOID:1712); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:24675); (R-RNO-2025928); (R-RNO-2871809); (R-RNO-4086398); (R-RNO-5607763)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "2174876;23699505;2558657;25967121;37926341", "class_list": "", "function": "Calcineurin suppresses rat H9c2 cardiomyocyteprotective autophagy under chronic intermittent hypoxia by downregulating the AMPK pathway., [RefSeq, PubMed]; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32 (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LDJ7", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.53;3.1.3.52;3.1.3.67;3.1.3.-;3.1.3.27;2.7.11.22;3.1.3.74", "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0046983 protein dimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0006468 protein phosphorylation;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046716 muscle cell cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P20651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97531-1", "uniprot_id": "CIP4_RAT", "mass": 62799.0, "length": 547, "protein_name": "Cdc42-interacting protein 4", "gene_name": "Trip10", "organism": "Rat", "refseq_name": "cdc42-interacting protein 4 isoform 2", "refseq_ac": "NP_446372", "gene_names_uniprotkb": "Trip10; Cip4; Stp", "gene_names_refseq": "Cip4; STP; Trip10", "protein_names_uniprotkb": "Cdc42-interacting protein 4; Salt tolerant protein; TR-interacting protein 10; TRIP-10; Thyroid receptor-interacting protein 10", "protein_names_refseq": "TR-interacting protein 10; TRIP-10; cdc42-interacting protein 4 isoform 2; cdc42-interacting protein 4; salt tolerant protein; thyroid receptor-interacting protein 10", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (rno:116717); (R-RNO-8856828); (R-RNO-9013406)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "14502124;22673903;26097534;26287173;26854232;28848997;8954095", "class_list": "", "function": "ARHGAP12 negatively controls dendritic spine size via its RhoGAP activity and promotes, by interacting with CIP4, postsynaptic AMPA receptor endocytosis., [RefSeq, PubMed]; CIP4 overexpression represses E-cadherin expression by promoting beta-catenin translocation to the nucleus. Publication Status: Online-Only, [RefSeq, PubMed]; Calcitriol may protect diabetic nephropathy from fibrosis via inhibition of TGF-beta1 and CIP4. Publication Status: Online-Only, [RefSeq, PubMed]; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Also acts as a link between CDC42 signaling and regulation of the actin cytoskeleton. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization in the vicinity of membrane tubules by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization and dynamin may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. May be required for the lysosomal retention of FASLG/FASL (By similarity)., [UniProtKB]; The results suggest that the CIP4/Par6 complex plays an important role in the occurrence of epithelial-mesenchymal transition in TGF-beta1-stimulated epithelial kidney cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P744", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0005764 lysosome", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0032094 response to food;GO:0001837 epithelial to mesenchymal transition;GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97531-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18484-1", "uniprot_id": "AP2A2_RAT", "mass": 104045.0, "length": 938, "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "Ap2a2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ap2a2; Adtab", "gene_names_refseq": "", "protein_names_uniprotkb": "AP-2 complex subunit alpha-2; 100 kDa coated vesicle protein C; Adaptor protein complex AP-2 subunit alpha-2; Adaptor-related protein complex 2 subunit alpha-2; Alpha-adaptin C; Alpha2-adaptin; Clathrin assembly protein complex 2 alpha-C large chain; Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (R-RNO-177504); (R-RNO-2132295); (R-RNO-416993); (R-RNO-437239); (R-RNO-5099900); (R-RNO-5140745); (R-RNO-6798695); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8866427); (R-RNO-8964038)", "pathway_count": 11, "publication_count": 10, "publication_id_list": "12086608;1325787;14745134;15473838;18683930;22262466;2402467;2495531;25061211;38843836", "class_list": "", "function": "Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0019900 kinase binding;GO:0044877 protein-containing complex binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0031410 cytoplasmic vesicle;GO:0030122 AP-2 adaptor complex;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P18484-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47866-1", "uniprot_id": "CRHR2_RAT", "mass": 47693.0, "length": 411, "protein_name": "Corticotropin-releasing hormone receptor 2", "gene_name": "Crhr2", "organism": "Rat", "refseq_name": "corticotropin-releasing factor receptor 2 isoform 3 precursor", "refseq_ac": "NP_073205", "gene_names_uniprotkb": "Crhr2; Crf2r", "gene_names_refseq": "CRF-R 2; CRH-R 2; Crf2r; Crhr2", "protein_names_uniprotkb": "Corticotropin-releasing hormone receptor 2; CRF-R-2; CRF-R2; CRFR-2; CRH-R-2; CRH-R2; Corticotropin-releasing factor receptor 2", "protein_names_refseq": "CRF-R-2; CRF2; CRH-R-2; corticotrophin releasing hormone receptor 2; corticotropin-releasing factor receptor 2 isoform 3 precursor; corticotropin-releasing factor receptor 2; corticotropin-releasing factor receptor subtype 2", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); ischemia (Disease Ontology:DOID:326); functional colonic disease (Disease Ontology:DOID:3877); rhinitis (Disease Ontology:DOID:4483); muscular atrophy (Disease Ontology:DOID:767); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:64680); (R-RNO-373080)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16766521;32215915;34213722;34331656;36089237;7846062;8703220", "class_list": "", "function": "Cross-talk between dopamine D1 and corticotropin releasing factor type 2 receptors leads to occlusion of their ERK1/2 signaling., [RefSeq, PubMed]; Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief., [RefSeq, PubMed]; G protein-coupled receptor for CRH, UCN, UCN2 and UCN3 stress hormones, which plays a central role in whole body adaptation to stress (PubMed:7846062, PubMed:8703220). Has highest affinity for UCN, and much lower affinity for CRH, UNC2 and UCN3 (PubMed:8703220). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors, such as adenylate cyclase (By similarity). CRHR2 is coupled to G(s) G protein (GNAS), mediating activation of adenylate cyclase activity and production of cAMP (By similarity). CRHR2-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (PubMed:7846062)., [UniProtKB, PubMed, UniProtKB, PubMed]; G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels., [UniProtKB, UniProtKB, UniProtKB]; Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation., [RefSeq, PubMed]; The Double Insult of Neonatal Cystitis Plus Adult Somatic Inflammation Results in Corticotropin Releasing Factor Type II Receptor-Dependent Bladder Hypersensitivity in Female Rats., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "G3V948", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017046 peptide hormone binding;GO:0005179 hormone activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0015056 corticotrophin-releasing factor receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0090281 negative regulation of calcium ion import;GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:2000252 negative regulation of feeding behavior;GO:0035482 gastric motility;GO:2000293 negative regulation of defecation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P47866-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M7V7-1", "uniprot_id": "FAKD2_RAT", "mass": 77767.0, "length": 679, "protein_name": "FAST kinase domain-containing protein 2, mitochondrial", "gene_name": "Fastkd2", "organism": "Rat", "refseq_name": "FAST kinase domain-containing protein 2, mitochondrial isoform 2", "refseq_ac": "NP_001009673", "gene_names_uniprotkb": "Fastkd2", "gene_names_refseq": "Fastkd2; RGD1307883", "protein_names_uniprotkb": "FAST kinase domain-containing protein 2, mitochondrial", "protein_names_refseq": "FAST kinase domain-containing protein 2, mitochondrial isoform 2; FAST kinase domain-containing protein 2, mitochondrial", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency (Disease Ontology:DOID:0060286); combined oxidative phosphorylation deficiency 44 (Disease Ontology:DOID:0070424)", "pathway": " (rno:301463)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. May play a role in mitochondrial apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0000963 mitochondrial RNA processing;GO:0006396 RNA processing;GO:0006915 apoptotic process;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7V7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17178-1", "uniprot_id": "CP27A_RAT", "mass": 60733.0, "length": 533, "protein_name": "Sterol 26-hydroxylase, mitochondrial", "gene_name": "Cyp27a1", "organism": "Rat", "refseq_name": "sterol 26-hydroxylase, mitochondrial", "refseq_ac": "NP_849178", "gene_names_uniprotkb": "Cyp27a1; Cyp27", "gene_names_refseq": "Cyp27a1; Cyp27; P450C27", "protein_names_uniprotkb": "Sterol 26-hydroxylase, mitochondrial; 1.14.15.15; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; Cytochrome P-450C27/25; Cytochrome P450 27; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase", "protein_names_refseq": "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; cytochrome P-450c27/25; cytochrome P450 27; sterol 26-hydroxylase, mitochondrial; sterol 27-hydroxylase; vitamin D(3) 25-hydroxylase", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); extrahepatic cholestasis (Disease Ontology:DOID:13619); cerebrotendinous xanthomatosis (Disease Ontology:DOID:4810)", "pathway": " (rno:301517); (R-RNO-193368); (R-RNO-193775); (R-RNO-193807); (R-RNO-211976)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "1733943;19401463;19665519;2175615;2318307;24280213;7577965", "class_list": "", "function": "Cyp27a1 is present in glial cells and is regulated in response to LXR activation, consistent with the role played by astrocytes in the control of cholesterol metabolism and homeostasis in the brain in physiological conditions, [RefSeq, PubMed]; Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid. Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways. May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism. Catalyzes the conversion of 7-ketocholesterol (7-oxocholesterol) into 7-keto,27-hydroxycholesterol, a precursor of 7-keto,27-hydroxycholesterol, an active oxysterol that activates smoothened (SMO) and the smoothened signaling pathway. Plays a role in cholestanol metabolism in the cerebellum. Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation. Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium. May play a redundant role in vitamin D biosynthesis (By similarity). Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (PubMed:2175615)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Data indicate that inhibition of CYP27A1 activity or knockdown and deletion of the Cyp27a1 gene induced adipocyte differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64615;Q64639", "ec_number_list": "1.14.15.15", "go_molecular_function": "GO:0008123 cholesterol 7-alpha-monooxygenase activity;GO:0031073 cholesterol 26-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0008203 cholesterol metabolic process;GO:0006700 C21-steroid hormone biosynthetic process;GO:0006707 cholesterol catabolic process;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P17178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q32PX7-1", "uniprot_id": "FUBP1_RAT", "mass": 67197.0, "length": 639, "protein_name": "Far upstream element-binding protein 1", "gene_name": "Fubp1", "organism": "Rat", "refseq_name": "far upstream element-binding protein 1 isoform 1", "refseq_ac": "NP_001032742", "gene_names_uniprotkb": "Fubp1", "gene_names_refseq": "Fubp1", "protein_names_uniprotkb": "Far upstream element-binding protein 1; FBP; FUSE-binding protein 1", "protein_names_refseq": "FBP; FUSE-binding protein 1; far upstream element (FUSE) binding protein 1; far upstream element-binding protein 1 isoform 1", "tax_id": 10116, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colorectal carcinoma (Disease Ontology:DOID:0080199); traumatic brain injury (Disease Ontology:DOID:0081292); stomach cancer (Disease Ontology:DOID:10534); sciatic neuropathy (Disease Ontology:DOID:11446); breast cancer (Disease Ontology:DOID:1612); ovary epithelial cancer (Disease Ontology:DOID:2152); malignant astrocytoma (Disease Ontology:DOID:3069); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:654496)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0003723 RNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0031667 response to nutrient levels;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32PX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVG2-1", "uniprot_id": "E41L5_RAT", "mass": 81718.0, "length": 731, "protein_name": "Band 4.1-like protein 5", "gene_name": "Epb41l5", "organism": "Rat", "refseq_name": "band 4.1-like protein 5 isoform 2", "refseq_ac": "NP_001012023", "gene_names_uniprotkb": "Epb41l5; Epb4.1l5", "gene_names_refseq": "Epb4.1l5; Epb41l5", "protein_names_uniprotkb": "Band 4.1-like protein 5; Erythrocyte membrane protein band 4.1-like 5", "protein_names_refseq": "band 4.1-like protein 5 isoform 2; band 4.1-like protein 5; erythrocyte protein band 4.1-like 5", "tax_id": 10116, "disease": "proteinuria (Disease Ontology:DOID:576)", "pathway": " (R-RNO-6794361)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17920587;18683930", "class_list": "", "function": "Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0010608 post-transcriptional regulation of gene expression;GO:0000902 cell morphogenesis;GO:0030036 actin cytoskeleton organization;GO:0022408 negative regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5FVG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7A8-1", "uniprot_id": "ABD18_RAT", "mass": 53235.0, "length": 464, "protein_name": "Cardiolipin-specific deacylase, mitochondrial", "gene_name": "Abhd18", "organism": "Rat", "refseq_name": "protein ABHD18 precursor", "refseq_ac": "NP_001020210", "gene_names_uniprotkb": "Abhd18; LOC499602", "gene_names_refseq": "Abhd18", "protein_names_uniprotkb": "Cardiolipin-specific deacylase, mitochondrial; Abhydrolase domain-containing protein 18; Alpha/beta hydrolase domain-containing protein 18", "protein_names_refseq": "abhydrolase domain-containing protein 18; alpha/beta hydrolase domain-containing protein 18; protein ABHD18 precursor; protein ABHD18; uncharacterized protein C4orf29 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:499602)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydrolysis of an acyl chain from the tetra-acylated cardiolipin (CL) and produces the tri-acylated monolysocardiolipin (MLCL). Prefers CL with shorter and saturated fatty acyl chains as substrates. Together with Tafazzin (TAZ), it participates in the mechanism of CL remodeling, a process consisting of repetitive cycles of hydrolysis and reacylation of the fatty acids that make up CL, where the nascent acyl chains are replaced with longer, unsaturated chains., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RJK2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7A8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30729-1", "uniprot_id": "DRD4_RAT", "mass": 41294.0, "length": 387, "protein_name": "D(4) dopamine receptor", "gene_name": "Drd4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Drd4", "gene_names_refseq": "", "protein_names_uniprotkb": "D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); pervasive developmental disorder (Disease Ontology:DOID:0060040); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); antisocial personality disorder (Disease Ontology:DOID:10939); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); opioid abuse (Disease Ontology:DOID:11206); pathological gambling (Disease Ontology:DOID:12399); conduct disorder (Disease Ontology:DOID:12995); alcohol use disorder (Disease Ontology:DOID:1574); substance abuse (Disease Ontology:DOID:302); dyslexia (Disease Ontology:DOID:4428); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); cannabis abuse (Disease Ontology:DOID:9505); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25432); (R-RNO-390651); (R-RNO-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10832611;14499480;1554689;8078498", "class_list": "", "function": "Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (By similarity). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:10832611). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62610", "ec_number_list": "", "go_molecular_function": "GO:0004952 dopamine neurotransmitter receptor activity;GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go;GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0034776 response to histamine;GO:0050709 negative regulation of protein secretion;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0060406 positive regulation of penile erection;GO:0098828 modulation of inhibitory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P30729-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26817-1", "uniprot_id": "GRK2_RAT", "mass": 79785.0, "length": 689, "protein_name": "G protein-coupled receptor kinase 2", "gene_name": "Grk2", "organism": "Rat", "refseq_name": "beta-adrenergic receptor kinase 1", "refseq_ac": "NP_036908", "gene_names_uniprotkb": "Grk2; Adrbk1", "gene_names_refseq": "Adrbk1; BARK1; GRK-2; Grk2", "protein_names_uniprotkb": "G protein-coupled receptor kinase 2; 2.7.11.15; 2.7.11.16; Beta-ARK-1; Beta-adrenergic receptor kinase 1", "protein_names_refseq": "adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; beta-ARK-1; beta-adrenergic receptor kinase 1 beta ARK1; beta-adrenergic receptor kinase 1", "tax_id": 10116, "disease": "limb ischemia (Disease Ontology:DOID:0050852); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); impotence (Disease Ontology:DOID:1875); opiate dependence (Disease Ontology:DOID:2559); pituitary adenoma (Disease Ontology:DOID:3829); hyperglycemia (Disease Ontology:DOID:4195); liver cirrhosis (Disease Ontology:DOID:5082); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (rno:25238); (R-RNO-111933); (R-RNO-416476); (R-RNO-418555); (R-RNO-5635838); (R-RNO-8856825)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "1403099;1436718;17437535;20194499;22673903;28381559;31594751;33434531;34101933;37012864;37690571;9826657", "class_list": "", "function": "Down-regulation of A3AR signaling by IL-6-induced GRK2 activation contributes to Th17 cell differentiation., [RefSeq, PubMed]; GRK2 expression and catalytic activity are essential for vasoconstrictor/ERK-stimulated arterial smooth muscle proliferation., [RefSeq, PubMed]; GRK2 participation in cardiac hypertrophy induced by isoproterenol through the regulation of Nrf2 signaling and the promotion of NLRP3 inflammasome and oxidative stress., [RefSeq, PubMed]; Preventing transient degradation of GRK2 and AKT during early I/R might improve the potential of endogenous cardioprotection mechanisms and of conditioning strategies., [RefSeq, PubMed]; Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:1403099). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:1403099). Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:1403099). Phosphorylates catecholamine-activated ADRB2 to regulate physiological cardiomyocyte contraction rate responses (By similarity). Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (By similarity). Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO) signaling pathway by mediating phosphorylation of SMO, facilitating SMO trafficking into the cilium and the stimulation of SMO activity (By similarity). Also positively regulates SMO signaling by mediating phosphorylation of GPR161, a key inhibitor SMO signaling, promoting ciliary export of GPR161 (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Phosphorylates catecholamine-activated ADRB2 to regulate physiological cardiomyocyte contraction rate responses. Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The role of G-protein-coupled receptor kinase 2 in diabetic mechanical hyperalgesia in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.13;2.7.11.-;2.7.11.15;2.7.11.16;3.6.5.-;2.7.11.1", "go_molecular_function": "GO:0031851 kappa-type opioid receptor binding;GO:0031850 delta-type opioid receptor binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0072752 cellular response to rapamycin;GO:0010661 positive regulation of muscle cell apoptotic process;GO:0006468 protein phosphorylation;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P26817-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3T1L5-1", "uniprot_id": "ALG6_RAT", "mass": 57948.0, "length": 507, "protein_name": "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase", "gene_name": "Alg6", "organism": "Rat", "refseq_name": "dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor", "refseq_ac": "NP_001028881", "gene_names_uniprotkb": "Alg6", "gene_names_refseq": "Alg6", "protein_names_uniprotkb": "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; 2.4.1.267; Asparagine-linked glycosylation protein 6 homolog; Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase", "protein_names_refseq": "asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase); asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase); asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog; asparagine-linked glycosylation protein 6 homolog; dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor; dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase", "tax_id": 10116, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ic (Disease Ontology:DOID:0080555)", "pathway": " (rno:362547); (R-RNO-446193)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Man(9)GlcNAc(2)-PP-Dol to produce Glc(1)Man(9)GlcNAc(2)-PP-Dol. Glc(1)Man(9)GlcNAc(2)-PP-Dol is a substrate for ALG8, the following enzyme in the biosynthetic pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.267", "go_molecular_function": "GO:0042281 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity;GO:0046527 glucosyltransferase activity;GO:0016787 hydrolase activity;GO:0004519 endonuclease activity;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 150, "hit_score": 0.1, "record_id": "Q3T1L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33272-1", "uniprot_id": "CP2BC_RAT", "mass": 55797.0, "length": 492, "protein_name": "Cytochrome P450 2B12", "gene_name": "Cyp2b12", "organism": "Rat", "refseq_name": "cytochrome P450 2B12", "refseq_ac": "NP_058852", "gene_names_uniprotkb": "Cyp2b12; Cyp2b-12", "gene_names_refseq": "Cyp2b12; Cyp2b15", "protein_names_uniprotkb": "Cytochrome P450 2B12; 1.14.14.1; CYPIIB12", "protein_names_refseq": "CYPIIB12; cytochrome P-450b type b; cytochrome P450 2B12; cytochrome P450, family 2, subfamily b, polypeptide 15", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute myeloid leukemia (Disease Ontology:DOID:9119); neonatal abstinence syndrome (Disease Ontology:DOID:9828); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29295)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1445240", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P33272-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8A3-1", "uniprot_id": "DYRK3_RAT", "mass": 65511.0, "length": 586, "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 3", "gene_name": "Dyrk3", "organism": "Rat", "refseq_name": "dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform 1", "refseq_ac": "NP_001019938", "gene_names_uniprotkb": "Dyrk3", "gene_names_refseq": "Dyrk3", "protein_names_uniprotkb": "Dual specificity tyrosine-phosphorylation-regulated kinase 3; 2.7.12.1", "protein_names_refseq": "dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform 1; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3", "tax_id": 10116, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (rno:304775)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17292540;9748265", "class_list": "", "function": "Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material. Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1. Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3. Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis. Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling. When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling. Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.10.1;2.7.1.153;2.7.1.137;2.7.10.2;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.10.4;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;2.7.1.32;2.7.1.82;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0016607 nuclear speck", "go_biological_process": "GO:1903008 organelle disassembly;GO:0006468 protein phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V8A3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M848-1", "uniprot_id": "ORAI1_RAT", "mass": 33040.0, "length": 304, "protein_name": "Calcium release-activated calcium channel protein 1", "gene_name": "Orai1", "organism": "Rat", "refseq_name": "calcium release-activated calcium channel protein 1", "refseq_ac": "NP_001014004", "gene_names_uniprotkb": "Orai1; Cracm1; Tmem142a", "gene_names_refseq": "Orai1; RGD1311873", "protein_names_uniprotkb": "Calcium release-activated calcium channel protein 1; Protein orai-1; Transmembrane protein 142A", "protein_names_refseq": "calcium release-activated calcium channel protein 1; calcium release-activated calcium modulator 1; protein orai-1; transmembrane protein 142A", "tax_id": 10116, "disease": "Stormorken syndrome (Disease Ontology:DOID:0060354); tubular aggregate myopathy 2 (Disease Ontology:DOID:0080686); immunodeficiency 9 (Disease Ontology:DOID:0111976); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:304496)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16766533;21454685;23109337;33269647;37533369;37686206;38291755;38514055", "class_list": "", "function": "Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1 channel, which improves cardiac function after myocardial infarction., [RefSeq, PubMed]; Inhibition of altered Orai1 channels in Muller cells protects photoreceptors in retinal degeneration., [RefSeq, PubMed]; Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (By similarity). Assembles with ORAI2 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. Activates NFATC2/NFAT1 and NFATC3/NFAT4-mediated transcriptional responses. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription (By similarity). Assembles with ORAI3 to form channels that mediate store-independent Ca(2+) influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively (By similarity). Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Suppression of store-operated Ca(2+) entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion., [RefSeq, PubMed]; Suppression of store-operated channels function by Orai1 overexpression likely reflects a required stoichiometry between STIM1 and Orai1 [Orai1], [RefSeq, PubMed]; The Role and Mechanism of STIM1/Orai1-Regulated Ca[2+] Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus., [RefSeq, PubMed]; Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030426 growth cone;GO:0044853 plasma membrane raft", "go_biological_process": "GO:0051924 regulation of calcium ion transport;GO:0002250 adaptive immune response;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0070588 calcium ion transmembrane transport;GO:0017156 calcium-ion regulated exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5M848-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10066-1", "uniprot_id": "CRGB_RAT", "mass": 21089.0, "length": 175, "protein_name": "Gamma-crystallin B", "gene_name": "Crygb", "organism": "Rat", "refseq_name": "gamma-crystallin B", "refseq_ac": "NP_001103345", "gene_names_uniprotkb": "Crygb", "gene_names_refseq": "Cryg2; Crygb; Len", "protein_names_uniprotkb": "Gamma-crystallin B; Gamma-B-crystallin; Gamma-crystallin 1-2", "protein_names_refseq": "CRY-gamma-B; crystallin, gamma polypeptide 2; gamma-B-crystallin; gamma-crystallin 1-2; gamma-crystallin B", "tax_id": 10116, "disease": "cataract 39 multiple types (Disease Ontology:DOID:0110236)", "pathway": " (rno:301468)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2777080;3783678", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007601 visual perception;GO:0070307 lens fiber cell development;GO:0001654 eye development;GO:0002088 lens development in camera-type eye;GO:0070309 lens fiber cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P10066-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24587-1", "uniprot_id": "AKAP5_RAT", "mass": 75962.0, "length": 714, "protein_name": "A-kinase anchor protein 5", "gene_name": "Akap5", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Akap5; Akap150", "gene_names_refseq": "", "protein_names_uniprotkb": "A-kinase anchor protein 5; A-kinase anchor protein 150 kDa; AKAP 150; AKAP-5; P150; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (R-RNO-399719)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;24349250;2538452;38843836", "class_list": "", "function": "Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (By similarity). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (By similarity). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70593", "ec_number_list": "", "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0060090 molecular adaptor activity;GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0001934 positive regulation of protein phosphorylation;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007194 negative regulation of adenylate cyclase activity;GO:0021510 spinal cord development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P24587-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DRK1-1", "uniprot_id": "ENTP8_RAT", "mass": 54330.0, "length": 494, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 8", "gene_name": "Entpd8", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Entpd8", "gene_names_refseq": "", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 8; 3.6.1.5; E-NTPDase 8; NTPDase 8; NTPDase8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:613267); (R-RNO-8850843)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17095758", "class_list": "", "function": "Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity (By similarity). Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (PubMed:17095758). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:17095758). This activity contributes to the regulation of extracellular levels of nucleotides (PubMed:17095758). Hydrolyzes ATP and ADP and prefers triphosphonucleosides and adenine over uracil as substrates (PubMed:17095758). Does not hydrolyzes AMP (PubMed:17095758)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.6.1.16;3.6.1.53;3.1.4.-;3.6.1.6;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0004382 GDP phosphatase activity;GO:0043262 ADP phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0071222 cellular response to lipopolysaccharide;GO:0010996 response to auditory stimulus;GO:0071356 cellular response to tumor necrosis factor;GO:0009124 nucleoside monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5DRK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13207-1", "uniprot_id": "EDN3_RAT", "mass": 18453.0, "length": 167, "protein_name": "Endothelin-3", "gene_name": "Edn3", "organism": "Rat", "refseq_name": "endothelin-3 precursor", "refseq_ac": "NP_001071118", "gene_names_uniprotkb": "Edn3", "gene_names_refseq": "Edn3; Et3; RGD1564825; preproET-3", "protein_names_uniprotkb": "Endothelin-3; ET-3; PPET3; Preproendothelin-3", "protein_names_refseq": "ET-3; PPET3; endothelin-3 precursor; preproendothelin-3", "tax_id": 10116, "disease": "Waardenburg syndrome type 4B (Disease Ontology:DOID:0110954); Hirschsprung's disease (Disease Ontology:DOID:10487); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (rno:366270); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1378731;23370722;24040226;3045827", "class_list": "", "function": "A novel bidirectional interaction exists between endothelin-3 and retinoic acid in rat enteric nervous system precursors. Publication Status: Online-Only, [RefSeq, PubMed]; ET-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and nitric oxide production, [RefSeq, PubMed]; Endothelins are endothelium-derived vasoconstrictor peptides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0031708 endothelin B receptor binding;GO:0031705 bombesin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0043410 positive regulation of MAPK cascade;GO:0045987 positive regulation of smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P13207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70539-1", "uniprot_id": "ACV1C_RAT", "mass": 54842.0, "length": 493, "protein_name": "Activin receptor type-1C", "gene_name": "Acvr1c", "organism": "Rat", "refseq_name": "activin receptor type-1C precursor", "refseq_ac": "NP_620790", "gene_names_uniprotkb": "Acvr1c; Alk7", "gene_names_refseq": "Acvr1c; Alk-7; Alk7; habrec1", "protein_names_uniprotkb": "Activin receptor type-1C; 2.7.11.30; ACTR-IC; ALK-7; Activin receptor type IC; Activin receptor-like kinase 7", "protein_names_refseq": "ACTR-IC; TGF-beta type 1 receptor; activin A receptor, type IC; activin receptor type IC; activin receptor type-1C precursor; activin receptor type-1C; activin receptor-like kinase 7", "tax_id": 10116, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:245921); (R-RNO-1502540)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11084022;15196700;22550067;25577243;35666032;8875430;8940033;9920806", "class_list": "", "function": "ALK7 gene silencing has a protective effect on diabetes-induced aortic stiffness, insulin resistance and hyperlipidemia, thus implicating a new potential therapeutic approach to diabetic macrovascular stiffness., [RefSeq, PubMed]; Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats., [RefSeq, PubMed]; Data suggest that up-regulation of Nodal expression increases apoptosis of beta cells and is associated with increased Alk7 expression, activation of Smad3 signaling, and down-regulation of apoptosis regulatory proteins., [RefSeq, PubMed]; Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL (PubMed:15196700). Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells (PubMed:9920806, PubMed:11084022, PubMed:22550067). Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70603", "ec_number_list": "2.7.11.30", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding;GO:0016361 activin receptor activity, type I", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0048179 activin receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0021766 hippocampus development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P70539-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BJW9-1", "uniprot_id": "DJC25_RAT", "mass": 42107.0, "length": 357, "protein_name": "DnaJ homolog subfamily C member 25", "gene_name": "Dnajc25", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 25 precursor", "refseq_ac": "NP_001020192", "gene_names_uniprotkb": "Dnajc25", "gene_names_refseq": "Dnajc25", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 25", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 25; dnaJ homolog subfamily C member 25 precursor; dnaJ homolog subfamily C member 25", "tax_id": 10116, "disease": "", "pathway": " (rno:362526)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19112-1", "uniprot_id": "F16P1_RAT", "mass": 39609.0, "length": 363, "protein_name": "Fructose-1,6-bisphosphatase 1", "gene_name": "Fbp1", "organism": "Rat", "refseq_name": "fructose-1,6-bisphosphatase 1", "refseq_ac": "NP_036690", "gene_names_uniprotkb": "Fbp1; Fbp", "gene_names_refseq": "Fbp1; Fdp", "protein_names_uniprotkb": "Fructose-1,6-bisphosphatase 1; 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; FBPase 1; Liver FBPase", "protein_names_refseq": "D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; FBPase 1; Fructose-16- biphosphatase; fructose-1,6- biphosphatase 1; fructose-1,6-bisphosphatase 1; liver FBPase", "tax_id": 10116, "disease": "Keshan disease (Disease Ontology:DOID:0050083); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); polycystic ovary syndrome (Disease Ontology:DOID:11612); clubfoot (Disease Ontology:DOID:11836); head and neck cancer (Disease Ontology:DOID:11934); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Graves' disease (Disease Ontology:DOID:12361); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); porphyria cutanea tarda (Disease Ontology:DOID:3132); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); biliary tract cancer (Disease Ontology:DOID:4607); esophageal cancer (Disease Ontology:DOID:5041); fructose-1,6-bisphosphatase deficiency (Disease Ontology:DOID:5204); pneumonia (Disease Ontology:DOID:552); bronchitis (Disease Ontology:DOID:6132); reactive arthritis (Disease Ontology:DOID:6196); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); chronic myeloid leukemia (Disease Ontology:DOID:8552); oral cavity cancer (Disease Ontology:DOID:8618); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:24362); (R-RNO-70263)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1313010;1846613;19651254;22673903;26417114;2847161;6305949;7589895", "class_list": "", "function": "Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest energy metabolism (gluconeogenesis versus glycolysis) modulates aldolase B and fructose-1,6-bisphosphatase-1 activities in hepatocytes via their interaction suggesting their association confers catalytic advantage for both enzymes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 47, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64594", "ec_number_list": "3.1.3.11", "go_molecular_function": "GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016208 AMP binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0097403 cellular response to raffinose;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0032869 cellular response to insulin stimulus;GO:0071320 cellular response to cAMP", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P19112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97687-1", "uniprot_id": "ENTP1_RAT", "mass": 57408.0, "length": 511, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 1", "gene_name": "Entpd1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Entpd1; Cd39", "gene_names_refseq": "", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 1; 3.6.1.5; ATP diphosphohydrolase; ATP-DPH; ATPDase; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen; NTPDase1; Nucleoside triphosphate diphosphohydrolase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "hereditary spastic paraplegia 64 (Disease Ontology:DOID:0110815); pre-eclampsia (Disease Ontology:DOID:10591); hypothyroidism (Disease Ontology:DOID:1459); intrahepatic cholestasis (Disease Ontology:DOID:1852); transient cerebral ischemia (Disease Ontology:DOID:224); demyelinating disease (Disease Ontology:DOID:3213)", "pathway": " (rno:64519); (R-RNO-8850843)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22100451;9221928;9364474", "class_list": "", "function": "Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (PubMed:22100451, PubMed:9221928, PubMed:9364474). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:22100451, PubMed:9221928, PubMed:9364474). This activity contributes to the regulation of extracellular levels of nucleotides (PubMed:22100451, PubMed:9221928, PubMed:9364474). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates. This activity contributes to the regulation of extracellular levels of nucleotides. By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.6.5.2;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;3.6.1.1;2.3.2.27;3.6.5.-;5.6.2.4;3.6.5.3;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.6.1.62;3.6.1.64;3.6.5.5;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.6.1.16;3.6.1.53;3.1.4.-;3.6.5.4;3.6.1.6;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0046032 ADP catabolic process;GO:1903576 response to L-arginine;GO:0007186 G protein-coupled receptor signaling pathway;GO:0010332 response to gamma radiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97687-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5GRG2-1", "uniprot_id": "EST5A_RAT", "mass": 64417.0, "length": 575, "protein_name": "Carboxylesterase 5A", "gene_name": "Ces5a", "organism": "Rat", "refseq_name": "carboxylesterase 5A precursor", "refseq_ac": "NP_001012056", "gene_names_uniprotkb": "Ces5a; Ces7", "gene_names_refseq": "Ces5a; Ces5; Ces7", "protein_names_uniprotkb": "Carboxylesterase 5A; 3.1.1.1; Carboxylesterase-like urinary excreted protein homolog; Cauxin; Epididymis-specific gene 615 protein", "protein_names_refseq": "carboxylesterase 5A precursor; carboxylesterase 615; carboxylesterase 7; carboxylesterase-like urinary excreted protein homolog; cauxin; epididymis-specific gene 615 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:307660)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19727521;25475668", "class_list": "", "function": "CES5A plays an important role in sperm maturation and male fertility in the rat., [RefSeq, PubMed]; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.1;3.1.1.-;3.1.1.67", "go_molecular_function": "GO:0106435 carboxylesterase activity;GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5GRG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3ZAV8-1", "uniprot_id": "EDC4_RAT", "mass": 152596.0, "length": 1407, "protein_name": "Enhancer of mRNA-decapping protein 4", "gene_name": "Edc4", "organism": "Rat", "refseq_name": "enhancer of mRNA-decapping protein 4", "refseq_ac": "NP_001028240", "gene_names_uniprotkb": "Edc4; Nrn1l", "gene_names_refseq": "Edc4; LRRG00115; Nrn1l; RGD1309136", "protein_names_uniprotkb": "Enhancer of mRNA-decapping protein 4", "protein_names_refseq": "enhancer of mRNA-decapping protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:361399); (R-RNO-430039)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0005886 plasma membrane", "go_biological_process": "GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3ZAV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q568Z1-1", "uniprot_id": "F131B_RAT", "mass": 35928.0, "length": 332, "protein_name": "Protein FAM131B", "gene_name": "Fam131b", "organism": "Rat", "refseq_name": "protein FAM131B", "refseq_ac": "NP_001020217", "gene_names_uniprotkb": "Fam131b", "gene_names_refseq": "Fam131b", "protein_names_uniprotkb": "Protein FAM131B", "protein_names_refseq": "protein FAM131B", "tax_id": 10116, "disease": "", "pathway": " (rno:500102)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q568Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I0F1-1", "uniprot_id": "ABRX1_RAT", "mass": 45690.0, "length": 405, "protein_name": "BRCA1-A complex subunit Abraxas 1", "gene_name": "ABRAXAS1; Abraxas1", "organism": "Rat", "refseq_name": "BRCA1-A complex subunit Abraxas 1", "refseq_ac": "NP_001009633", "gene_names_uniprotkb": "ABRAXAS1; Abraxas1; Abra1; Ccdc98; Fam175a", "gene_names_refseq": "Abraxas1; Ccdc98; Fam175a; RGD1305287", "protein_names_uniprotkb": "BRCA1-A complex subunit Abraxas 1; Coiled-coil domain-containing protein 98; Protein FAM175A", "protein_names_refseq": "BRCA1-A complex subunit Abraxas 1; coiled-coil domain containing 98; coiled-coil domain-containing protein 98; family with sequence similarity 175, member A", "tax_id": 10116, "disease": "", "pathway": " (rno:289468); (R-RNO-5689901); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-69473)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0090307 mitotic spindle assembly;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499N4-1", "uniprot_id": "COQ2_RAT", "mass": 40406.0, "length": 374, "protein_name": "4-hydroxybenzoate polyprenyltransferase, mitochondrial", "gene_name": "Coq2", "organism": "Rat", "refseq_name": "4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor", "refseq_ac": "NP_001037720", "gene_names_uniprotkb": "Coq2; COQ2", "gene_names_refseq": "Coq2; PHB:PPT; RGD1306722", "protein_names_uniprotkb": "4-hydroxybenzoate polyprenyltransferase, mitochondrial; 2.5.1.39; 4-HB polyprenyltransferase; PHB:PPT; PHB:polyprenyltransferase; Para-hydroxybenzoate--polyprenyltransferase", "protein_names_refseq": "4-HB polyprenyltransferase; 4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor; 4-hydroxybenzoate polyprenyltransferase, mitochondrial; PHB:polyprenyltransferase; coenzyme Q2 4-hydroxybenzoate polyprenyltransferase; coenzyme Q2 homolog, prenyltransferase; para-hydroxybenzoate--polyprenyltransferase, mitochondrial", "tax_id": 10116, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 1 (Disease Ontology:DOID:0070238); glucose intolerance (Disease Ontology:DOID:10603); nephrotic syndrome (Disease Ontology:DOID:1184); multiple system atrophy (Disease Ontology:DOID:4752)", "pathway": " (rno:498332); (R-RNO-1268020); (R-RNO-2142789)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "20526342;22387164;26296322", "class_list": "", "function": "Coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are differentially expressed in obese rats, suggesting that these two genes are candidates for the onset of type 2 diabetes associated with obesity in rats., [RefSeq, PubMed]; Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis (PubMed:20526342). Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group (such as all-trans-nonaprenyl diphosphate) (PubMed:20526342). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9 (PubMed:20526342). However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10 (By similarity). Plays a central role in the biosynthesis of CoQ9 (By similarity). CoQ9 is a vital molecule that transports electrons from mitochondrial respiratory chain complexes (By similarity). CoQs also function as cofactors for uncoupling protein and plays a role as regulator of the extracellularly-induced ceramide-dependent apoptotic pathway (By similarity). Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner (PubMed:22387164)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis. Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-decaprenyl diphosphate or trans-nonaprenyl diphosphate). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9. However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10. CoQs are vital molecules that transport electrons from mitochondrial respiratory chain complexes. CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway. Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.-;2.5.1.39;1.16.3.1;2.1.3.3;7.1.2.2;5.6.1.7", "go_molecular_function": "GO:0004659 prenyltransferase activity;GO:0008412 4-hydroxybenzoate polyprenyltransferase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0006071 glycerol metabolic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q499N4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09660-1", "uniprot_id": "ACHE_RAT", "mass": 54948.0, "length": 494, "protein_name": "Acetylcholine receptor subunit epsilon", "gene_name": "Chrne", "organism": "Rat", "refseq_name": "acetylcholine receptor subunit epsilon precursor", "refseq_ac": "NP_058890", "gene_names_uniprotkb": "Chrne; Achre", "gene_names_refseq": "Chrne; nAChR", "protein_names_uniprotkb": "Acetylcholine receptor subunit epsilon", "protein_names_refseq": "acetylcholine receptor epsilon; acetylcholine receptor subunit epsilon precursor; acetylcholine receptor subunit epsilon; cholinergic receptor, nicotinic epsilon; cholinergic receptor, nicotinic, epsilon (muscle); cholinergic receptor, nicotinic, epsilon polypeptide; epsilon-subunit; gene for acetylcholine receptor epsilon subunit", "tax_id": 10116, "disease": "congenital myasthenic syndrome 4B (Disease Ontology:DOID:0110677); congenital myasthenic syndrome 4A (Disease Ontology:DOID:0110678); congenital myasthenic syndrome 4C (Disease Ontology:DOID:0110679)", "pathway": " (rno:29422); (R-RNO-629587)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1702709;3205730;3666131;8034713", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6LAD4", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0031594 neuromuscular junction;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0007271 synaptic transmission, cholinergic;GO:0042391 regulation of membrane potential;GO:0095500 acetylcholine receptor signaling pathway;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09660-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23943-1", "uniprot_id": "EDN2_RAT", "mass": 19478.0, "length": 176, "protein_name": "Endothelin-2", "gene_name": "Edn2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Edn2", "gene_names_refseq": "", "protein_names_uniprotkb": "Endothelin-2; ET-2; PPET2; Preproendothelin-2; VIC; Vasoactive intestinal contractor", "protein_names_refseq": "", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:24324); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "1840558;9060420", "class_list": "", "function": "Vasoconstrictor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0031708 endothelin B receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0001543 ovarian follicle rupture;GO:0001525 angiogenesis;GO:0001659 temperature homeostasis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P23943-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08503-1", "uniprot_id": "ACADM_RAT", "mass": 46555.0, "length": 421, "protein_name": "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "Acadm", "organism": "Rat", "refseq_name": "medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": "NP_058682", "gene_names_uniprotkb": "Acadm", "gene_names_refseq": "Acadm; MCAD", "protein_names_uniprotkb": "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.7; MCAD", "protein_names_refseq": "Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight-chain; acyl-CoA dehydrogenase, C-4 to C-12 straight chain; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; acyl-Coenzyme A dehydrogenase, medium chain; medium-chain acyl-CoA dehydrogenase; medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "medium chain acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0080153); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (rno:24158); (R-RNO-77288); (R-RNO-77346); (R-RNO-77348)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "2029527;27213235;32227582;3611054;3813556;3968063", "class_list": "", "function": "Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA) (PubMed:3968063). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16 (PubMed:3968063)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PiRNA-63076 contributes to pulmonary arterial smooth muscle cell proliferation through acyl-CoA dehydrogenase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.8.7;1.3.8.8;1.3.8.4;1.3.8.1;1.3.8.9;1.3.8.5", "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030424 axon;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0001889 liver development;GO:0006635 fatty acid beta-oxidation;GO:0007507 heart development;GO:0007584 response to nutrient;GO:0009409 response to cold", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P08503-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23377-1", "uniprot_id": "FURIN_RAT", "mass": 86653.0, "length": 793, "protein_name": "Furin", "gene_name": "Furin", "organism": "Rat", "refseq_name": "furin precursor", "refseq_ac": "NP_062204", "gene_names_uniprotkb": "Furin; Fur; Pcsk3", "gene_names_refseq": "Furin; Pace; Pcsk3", "protein_names_uniprotkb": "Furin; 3.4.21.75; Dibasic-processing enzyme; PACE; Paired basic amino acid residue-cleaving enzyme; Prohormone convertase 3", "protein_names_refseq": "Paired basic amino acid cleaving enzyme (furin); Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein); dibasic-processing enzyme; furin precursor; paired basic amino acid residue-cleaving enzyme; prohormone convertase 3; proprotein convertase subtilisin/kexin type3", "tax_id": 10116, "disease": "arteriosclerosis (Disease Ontology:DOID:2349); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:54281); (R-RNO-1442490); (R-RNO-1566948); (R-RNO-1592389); (R-RNO-159782); (R-RNO-167060); (R-RNO-186797); (R-RNO-2173789); (R-RNO-2173796); (R-RNO-8963889); (R-RNO-9768727); (R-RNO-9953170)", "pathway_count": 12, "publication_count": 7, "publication_id_list": "21454685;2251148;23686857;31336100;36063111;9252368;9695949", "class_list": "", "function": "MiR-22-3p in exosomes increases the risk of heart failure after down-regulation of FURIN., [RefSeq, PubMed]; Overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner, [RefSeq, PubMed]; TGFbeta treatment aggravated hypoxia-induced BBB permeability but ALK5 or Furin blockade reversed injury-induced permeability changes. Thus during insult Furin compromises endothelial integrity by mediating the effects of TGFbeta. Targeting the Furin or ALK5 pathway may offer novel therapeutic strategies for improving BBB stability and CNS function during disease., [RefSeq, PubMed]; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:9252368). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-45) (PubMed:9252368). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.-;3.4.21.22;3.4.21.5;3.4.21.75;3.4.21.69;3.4.21.-;3.1.1.32;3.1.1.34;3.4.24.80;3.4.21.6;3.6.5.-;3.4.21.21", "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0002020 protease binding;GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen", "go_biological_process": "GO:0019058 viral life cycle;GO:0032902 nerve growth factor production;GO:0090472 dibasic protein processing;GO:0097341 zymogen inhibition;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P23377-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q460M5-1", "uniprot_id": "LRFN2_RAT", "mass": 84917.0, "length": 788, "protein_name": "Leucine-rich repeat and fibronectin type-III domain-containing protein 2", "gene_name": "Lrfn2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lrfn2; Salm1", "gene_names_refseq": "", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type-III domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:316205); (R-RNO-8849932)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16495444;18227064;18585462;38843836", "class_list": "", "function": "Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of GRIN1 and GRIN2A NMDA receptor subunits. May play a role in redistributing DLG4 to the cell periphery (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098794 postsynapse;GO:0098793 presynapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0099175 regulation of postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q460M5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18886-1", "uniprot_id": "CPT2_RAT", "mass": 74110.0, "length": 658, "protein_name": "Carnitine O-palmitoyltransferase 2, mitochondrial", "gene_name": "Cpt2", "organism": "Rat", "refseq_name": "carnitine O-palmitoyltransferase 2, mitochondrial isoform 1 precursor", "refseq_ac": "NP_037062", "gene_names_uniprotkb": "Cpt2; Cpt-2", "gene_names_refseq": "CPTII; Cpt2", "protein_names_uniprotkb": "Carnitine O-palmitoyltransferase 2, mitochondrial; 2.3.1.21; CPT II; Carnitine palmitoyltransferase II", "protein_names_refseq": "carnitine O-palmitoyltransferase 2, mitochondrial isoform 1 precursor; carnitine O-palmitoyltransferase 2, mitochondrial; carnitine palmitoyltransferase II", "tax_id": 10116, "disease": "muscular disease (Disease Ontology:DOID:0080000); cataract 3 multiple types (Disease Ontology:DOID:0110269); lipid metabolism disorder (Disease Ontology:DOID:3146); cataract (Disease Ontology:DOID:83); brain disease (Disease Ontology:DOID:936)", "pathway": " (rno:25413); (R-RNO-200425); (R-RNO-77305)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "16615913;16781677;17585909;1869564;2355018;26446791;28127199;34350838;34502162;38171776;38428407;9136891", "class_list": "", "function": "GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription., [RefSeq, PubMed]; Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Low CPT-II expression might lead to abnormal hepatic lipid accumulation, which should promote the malignant transformation of hepatocytes., [RefSeq, PubMed]; The effects of exercise on skeletal and heart muscle citrate synthase and carnitine palmitoyltransferase mRNA expressions in high-calorie fed rats., [RefSeq, PubMed]; Unique Behavior of Bacterially Expressed Rat Carnitine Palmitoyltransferase 2 and Its Catalytic Activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97781", "ec_number_list": "2.3.1.21;3.1.2.22;2.3.1.137;2.3.1.-;2.3.1.7", "go_molecular_function": "GO:0004095 carnitine O-palmitoyltransferase activity;GO:0008458 carnitine O-octanoyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0001701 in utero embryonic development;GO:0006635 fatty acid beta-oxidation;GO:0006853 carnitine shuttle;GO:0015909 long-chain fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P18886-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61206-1", "uniprot_id": "ARF3_RAT", "mass": 20601.0, "length": 181, "protein_name": "ADP-ribosylation factor 3", "gene_name": "Arf2; Arf3; Fkbp11", "organism": "Rat", "refseq_name": "ADP-ribosylation factor 3", "refseq_ac": "NP_543180", "gene_names_uniprotkb": "Arf2; Arf3; Fkbp11; Ac1-253; Arf1; Arf3", "gene_names_refseq": "Ac1-253; Arf3", "protein_names_uniprotkb": "ADP-ribosylation factor 3; Liver regeneration-related protein LRRG202", "protein_names_refseq": "ADP-ribosylation factor 3; liver regeneration-related protein LRRG202", "tax_id": 10116, "disease": "", "pathway": " (rno:140940); (rno:300211); (R-RNO-1660514); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "34502162;38843836;8813705", "class_list": "", "function": "GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB]; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus., [UniProtKB]; PPIases accelerate the folding of proteins during protein synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P16587", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P61206-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00911-1", "uniprot_id": "EGR4_RAT", "mass": 49668.0, "length": 478, "protein_name": "Early growth response protein 4", "gene_name": "Egr4", "organism": "Rat", "refseq_name": "early growth response protein 4", "refseq_ac": "NP_062010", "gene_names_uniprotkb": "Egr4; Egr-4; Ngfic", "gene_names_refseq": "Egr4l1; Egr4; NGFI-C", "protein_names_uniprotkb": "Early growth response protein 4; EGR-4; Early response protein NGFI-C; NGFI-C; Nerve growth factor-induced protein C", "protein_names_refseq": "EGR-4; early growth response protein 4; early response protein NGFI-C; nerve growth factor-induced protein C; zinc-finger transcription factor NGFI-C (early response gene)", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:25129)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1584812;2072895;29580816", "class_list": "", "function": "Pregulation of Egr2 and Egr4 could demote the activation of JNK/c-JUN pathway and the expression of pro-inflammatory cytokines in MCAO rats, so that Egr2 and Egr4 might be potential targets for ischemic stroke in future, [RefSeq, PubMed]; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q00911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70473-1", "uniprot_id": "AMACR_RAT", "mass": 41828.0, "length": 382, "protein_name": "Alpha-methylacyl-CoA racemase", "gene_name": "Amacr", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Amacr", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-methylacyl-CoA racemase; 2-arylpropionyl-CoA epimerase; 2-methylacyl-CoA racemase; 5.1.99.4", "protein_names_refseq": "", "tax_id": 10116, "disease": "alpha-methylacyl-CoA racemase deficiency (Disease Ontology:DOID:0060602); keratosis palmoplantaris striata 1 (Disease Ontology:DOID:0081108); congenital bile acid synthesis defect 4 (Disease Ontology:DOID:0111068); urinary bladder cancer (Disease Ontology:DOID:11054); breast carcinoma (Disease Ontology:DOID:3459); renal cell carcinoma (Disease Ontology:DOID:4450); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:25284); (R-RNO-193368); (R-RNO-193775); (R-RNO-389887); (R-RNO-9033241)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10770938;11060359;29393594;7649182;8020470;8615858;9106621;9307041", "class_list": "", "function": "Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:8020470, PubMed:9106621). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:8020470, PubMed:9106621)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09176", "ec_number_list": "1.1.3.15;1.2.3.5;3.4.21.-;2.3.2.27;1.4.3.1;1.4.3.3;3.1.2.2;3.1.2.-;1.11.1.6;1.3.3.6;2.6.1.51;2.6.1.44;2.3.1.137;2.3.1.176;2.3.1.16;2.3.1.155;2.3.2.36;2.5.1.18;3.4.24.56;1.1.1.42;5.1.99.4;4.1.3.4;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;1.14.13.39;3.4.21.53;5.3.3.8;5.3.3.21;3.1.2.27;2.3.1.65;3.6.1.-;3.6.1.77;2.3.1.7;4.1.2.63;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;1.1.1.300;1.1.1.184;4.1.1.9;2.3.1.42;1.3.1.38;2.7.4.6;1.3.1.124", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008111 alpha-methylacyl-CoA racemase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006699 bile acid biosynthetic process;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P70473-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23944-1", "uniprot_id": "ADA1D_RAT", "mass": 59354.0, "length": 561, "protein_name": "Alpha-1D adrenergic receptor", "gene_name": "Adra1d", "organism": "Rat", "refseq_name": "alpha-1D adrenergic receptor", "refseq_ac": "NP_077809", "gene_names_uniprotkb": "Adra1d; Adra1a", "gene_names_refseq": "Adra1d; Adrd1", "protein_names_uniprotkb": "Alpha-1D adrenergic receptor; Alpha-1A adrenergic receptor; Alpha-1D adrenoceptor; Alpha-1D adrenoreceptor; RA42", "protein_names_refseq": "RA42; adrenergic receptor delta1; adrenergic receptor, alpha 1d; adrenergic, alpha-1D-, receptor; alpha-1A adrenergic receptor; alpha-1D adrenergic receptor; alpha-1D adrenoceptor; alpha-1D adrenoreceptor", "tax_id": 10116, "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (rno:29413); (R-RNO-390696); (R-RNO-416476); (R-RNO-416482)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10570042;1334487;1661838;1706716;26593425;27605559;34062902;7815325", "class_list": "", "function": "Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11) (PubMed:1334487). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C (PubMed:1334487). ADRA1D binds the catecholamine ligands norepinephrine and epinephrine (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Antidepressants Differentially Regulate Intracellular Signaling from alpha1-Adrenergic Receptor Subtypes In Vitro. Publication Status: Online-Only, [RefSeq, PubMed]; Effects of female sexual hormones on the expression and function of alpha1A- and alpha1D-adrenoceptor subtypes in the late-pregnant rat myometrium, [RefSeq, PubMed]; These results suggest that alpha-blockade reduces the urethral resistance associated with detrusor-sphincter dyssynergia, thus improving voiding efficiency in SCI rats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q71UM4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004937 alpha1-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P23944-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C7N2-1", "uniprot_id": "ERIC4_RAT", "mass": 15840.0, "length": 143, "protein_name": "Glutamate-rich protein 4", "gene_name": "Erich4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Erich4; LOC685046", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutamate-rich protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:685046)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C7N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13676-1", "uniprot_id": "ACPH_RAT", "mass": 81384.0, "length": 732, "protein_name": "Acylamino-acid-releasing enzyme", "gene_name": "Apeh", "organism": "Rat", "refseq_name": "acylamino-acid-releasing enzyme", "refseq_ac": "NP_036632", "gene_names_uniprotkb": "Apeh", "gene_names_refseq": "Apeh14; Apeh17; Apeh; fMAP", "protein_names_uniprotkb": "Acylamino-acid-releasing enzyme; 3.4.19.1; AARE; APH; Acyl-peptide hydrolase; Acylaminoacyl-peptidase; fMAP; fMet aminopeptidase", "protein_names_refseq": "AARE; APH; N-acylaminoacyl-peptide hydrolase; acyl-peptide hydrolase; acylamino-acid-releasing enzyme; acylaminoacyl-peptidase; acylpeptide hydrolase; fMet aminopeptidase", "tax_id": 10116, "disease": "", "pathway": " (rno:24206); (R-RNO-6798695); (R-RNO-72764)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15938642;22640895;22673903;2578023;2722805;3305492", "class_list": "", "function": "ACPH protein levels are significantly increased at the synapse; ACPH is preferentially located at the pre-synaptic side, [RefSeq, PubMed]; Aminopeptidase involved in the degradation of N(alpha)-acylated peptides. Displays exopeptidase activity toward N-formyl and N-acetyl peptides with a preference for dipeptide substrates (PubMed:15938642, PubMed:3305492). Catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:3305492). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (PubMed:3305492). Hydrolyzes N-formylated peptides arising from N-terminal proteolytic cleavage of bacterial and mitochondrial proteins (PubMed:15938642). May act sequentially with ACY1 in the degradation of N-acylated peptides: APEH first cleaves N-acylaminoacids from N-acylated peptides, then ACY1 further hydrolyzes the N-acylaminoacid into free aminoacid and a carboxylate (PubMed:15938642). Displays endopeptidase activity involved in the degradation of oxidized and glycated proteins (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P14320;P70479", "ec_number_list": "5.2.1.8;1.1.1.205;3.2.1.23;3.5.4.5;2.3.2.5;3.6.4.13;2.4.1.25;3.2.1.33;4.2.99.18;5.6.2.4;4.1.2.4;2.4.1.186;3.5.4.6;3.1.1.47;3.4.22.1;1.11.1.6;2.5.1.18;4.1.2.13;3.6.5.-;4.2.1.24;3.2.1.31;2.4.1.1;2.7.10.2;2.7.11.1;2.7.1.40;1.13.11.-;1.13.11.34;3.4.19.1;2.3.3.8;1.16.3.1;2.7.4.6;2.7.13.3;3.4.23.5;5.4.2.11;5.4.2.4;2.7.1.1;3.3.2.6;3.4.11.4;2.7.1.11;5.3.2.1;5.3.3.12;3.4.21.46;5.4.2.2;1.1.1.42;3.6.4.6;3.4.24.35;3.1.6.12;2.3.2.26;3.6.4.10;2.7.11.24;2.4.2.1;3.4.22.52;3.4.22.27;5.3.1.9;5.1.3.-;3.5.1.23;3.5.1.-;3.6.1.6;3.4.25.1;3.4.18.1;1.11.1.24", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008242 omega peptidase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0050435 amyloid-beta metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P13676-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10068-1", "uniprot_id": "CRGF_RAT", "mass": 21342.0, "length": 174, "protein_name": "Gamma-crystallin F", "gene_name": "Crygf", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Crygf", "gene_names_refseq": "", "protein_names_uniprotkb": "Gamma-crystallin F; Gamma-F-crystallin; Gamma-crystallin 4-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "cataract 4 multiple types (Disease Ontology:DOID:0110234); cataract 7 (Disease Ontology:DOID:0110260)", "pathway": " (rno:689947)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2777080;3783678", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P10068-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04400-1", "uniprot_id": "ADCY5_RAT", "mass": 139179.0, "length": 1262, "protein_name": "Adenylate cyclase type 5", "gene_name": "Adcy5", "organism": "Rat", "refseq_name": "adenylate cyclase type 5", "refseq_ac": "NP_072122", "gene_names_uniprotkb": "Adcy5", "gene_names_refseq": "Adcy5", "protein_names_uniprotkb": "Adenylate cyclase type 5; 4.6.1.1; ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5", "protein_names_refseq": "ATP pyrophosphate-lyase 5; adenylate cyclase type 5; adenylate cyclase type V; adenylyl cyclase 5; adenylyl cyclase type V", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:64532); (R-RNO-163615); (R-RNO-170660); (R-RNO-170670); (R-RNO-400042); (R-RNO-418597); (R-RNO-5610787)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "1409703", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:1409703). Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion., [UniProtKB, PubMed, UniProtKB]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.1;3.6.5.-", "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008179 adenylate cyclase binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007507 heart development;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q04400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02667-1", "uniprot_id": "CS2LA_RAT", "mass": 20278.0, "length": 179, "protein_name": "Alpha-S2-casein-like A", "gene_name": "Csn1s2a", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Csn1s2a; Csng", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-S2-casein-like A; Casein alpha S2-like A; Gamma-casein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:114595)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "6298707", "class_list": "", "function": "Important role in the capacity of milk to transport calcium phosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0035375 zymogen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P02667-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36953-1", "uniprot_id": "AFAM_RAT", "mass": 69335.0, "length": 608, "protein_name": "Afamin", "gene_name": "Afm", "organism": "Rat", "refseq_name": "afamin precursor", "refseq_ac": "NP_758823", "gene_names_uniprotkb": "Afm", "gene_names_refseq": "Afm", "protein_names_uniprotkb": "Afamin; Alpha-Alb; Alpha-albumin", "protein_names_refseq": "afamin precursor; alpha-Alb; alpha-albumin", "tax_id": 10116, "disease": "", "pathway": " (rno:282708)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7509788", "class_list": "", "function": "Functions as a carrier for hydrophobic molecules in body fluids. Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B. Binds vitamin E. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the transport of vitamin E across the blood-brain barrier., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008431 vitamin E binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0071693 protein transport within extracellular region;GO:0031667 response to nutrient levels;GO:0050821 protein stabilization;GO:0051180 vitamin transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P36953-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05754-1", "uniprot_id": "DOPO_RAT", "mass": 69875.0, "length": 620, "protein_name": "Dopamine beta-hydroxylase", "gene_name": "Dbh", "organism": "Rat", "refseq_name": "dopamine beta-hydroxylase precursor", "refseq_ac": "NP_037290", "gene_names_uniprotkb": "Dbh", "gene_names_refseq": "DOPBHY; Dbh", "protein_names_uniprotkb": "Dopamine beta-hydroxylase; 1.14.17.1; Dopamine beta-monooxygenase", "protein_names_refseq": "Dopamine beta hydroxylase (dopamine beta-monooxygenase); dopamine beta-hydroxylase precursor; dopamine beta-monooxygenase", "tax_id": 10116, "disease": "dopamine beta-hydroxylase deficiency (Disease Ontology:DOID:0090145); migraine with aura (Disease Ontology:DOID:10024); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (rno:25699); (R-RNO-209905)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11418593;2325165;27959576;28473232;28726094;7798920", "class_list": "", "function": "Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Genetically determined decreases in adrenal expression and activity of DBH do not represent primary determinants of increased blood pressure in the SHR model, [RefSeq, PubMed]; Study revealed age-related changes in tyrosine hydroxylase and DBH immunoreactivities in the carotid body glomus cells of spontaneously hypertensive (SHR/Izm) and Wistar Kyoto (WKY/Izm) rats at 4, 8, 12, and 16 weeks of age using immunohistochemistry. DBH age-dependently increased in the glomus cells of SHR/Izm in contrast to WKY/Izm., [RefSeq, PubMed]; Tyrosine hydroxylase and dopamine beta-hydroxylase-was evaluated in the organ of Zuckerkandl of rats in the critical period of morphogenesis, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.17.1", "go_molecular_function": "GO:0005507 copper ion binding;GO:0031418 L-ascorbic acid binding;GO:0004500 dopamine beta-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030424 axon;GO:0030425 dendrite;GO:0034774 secretory granule lumen;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007613 memory;GO:0007626 locomotory behavior;GO:0008306 associative learning;GO:0008542 visual learning;GO:0035900 response to isolation stress", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q05754-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4W8E7-1", "uniprot_id": "AJAP1_RAT", "mass": 44755.0, "length": 411, "protein_name": "Adherens junction-associated protein 1", "gene_name": "Ajap1", "organism": "Rat", "refseq_name": "adherens junction-associated protein 1 precursor", "refseq_ac": "NP_001094484", "gene_names_uniprotkb": "Ajap1; Neumo48", "gene_names_refseq": "Ajap1; neumo48", "protein_names_uniprotkb": "Adherens junction-associated protein 1", "protein_names_refseq": "adherens junction-associated protein 1 precursor; adherens junction-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:687031)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in cell adhesion and cell migration., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0044877 protein-containing complex binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0001953 negative regulation of cell-matrix adhesion;GO:0061045 negative regulation of wound healing;GO:0030860 regulation of polarized epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4W8E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F2L1-1", "uniprot_id": "OFUT3_RAT", "mass": 56025.0, "length": 483, "protein_name": "GDP-fucose protein O-fucosyltransferase 3", "gene_name": "Pofut3", "organism": "Rat", "refseq_name": "GDP-fucose protein O-fucosyltransferase 3 isoform 2", "refseq_ac": "NP_001012360", "gene_names_uniprotkb": "Pofut3; Fut10; fut10", "gene_names_refseq": "Fut10; Pofut3; fut10A", "protein_names_uniprotkb": "GDP-fucose protein O-fucosyltransferase 3; 2.4.1.-; 2.4.1.221; Alpha-(1,3)-fucosyltransferase 10; Fuc-TX; FucT-X; Fucosyltransferase 10; Fucosyltransferase X; Galactoside 3-L-fucosyltransferase 10", "protein_names_refseq": "GDP-fucose protein O-fucosyltransferase 3 isoform 2; GDP-fucose protein O-fucosyltransferase 3; alpha-(1,3)-fucosyltransferase 10; alpha3-fucosyltransferase; fuc-TX; fucT-X; fucosyltransferase X; galactoside 3-L-fucosyltransferase 10", "tax_id": 10116, "disease": "", "pathway": " (rno:497619); (R-RNO-5173105)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion. May also show alpha-(1,3)-fucosyltransferase activity toward the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. However, this was tested with a library of synthetic substrates and this activity is unsure in vivo. May be involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5F2N5", "ec_number_list": "2.4.1.221;2.4.1.-", "go_molecular_function": "GO:0046922 peptide-O-fucosyltransferase activity;GO:0008417 fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050714 positive regulation of protein secretion;GO:0006491 N-glycan processing;GO:0036445 neuronal stem cell division;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 1641, "hit_score": 0.1, "record_id": "Q5F2L1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35444-1", "uniprot_id": "COMP_RAT", "mass": 82664.0, "length": 755, "protein_name": "Cartilage oligomeric matrix protein", "gene_name": "Comp", "organism": "Rat", "refseq_name": "cartilage oligomeric matrix protein precursor", "refseq_ac": "NP_036966", "gene_names_uniprotkb": "Comp", "gene_names_refseq": "Comp", "protein_names_uniprotkb": "Cartilage oligomeric matrix protein; COMP", "protein_names_refseq": "cartilage oligomeric matrix protein precursor", "tax_id": 10116, "disease": "multiple epiphyseal dysplasia 1 (Disease Ontology:DOID:0070303); carpal tunnel syndrome 2 (Disease Ontology:DOID:0070467); pseudoachondroplasia (Disease Ontology:DOID:0080047); multiple epiphyseal dysplasia (Disease Ontology:DOID:12721); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (rno:25304); (R-RNO-216083)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1429587;20019333;28860005;29867124;34395611;35080151;35468843;8864111", "class_list": "", "function": "A Study on COMP and CTX-II as Molecular Markers for the Diagnosis of Intervertebral Disc Degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; COMP could normally have a protective role against PASMC phenotype switching, [RefSeq, PubMed]; COMP-prohibitin 2 interaction in mitochondria plays an important role in maintaining the contractile phenotype of Vascular smooth muscle cells by regulating mitochondrial oxidative phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (PubMed:20019333)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0016485 protein processing;GO:0043066 negative regulation of apoptotic process;GO:0050881 musculoskeletal movement;GO:0050905 neuromuscular process;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P35444-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24388-1", "uniprot_id": "CRHBP_RAT", "mass": 36121.0, "length": 322, "protein_name": "Corticotropin-releasing hormone-binding protein", "gene_name": "Crhbp", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Crhbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Corticotropin-releasing hormone-binding protein; CRF-BP; CRF-binding protein; CRH-BP; Corticotropin-releasing factor-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "opioid abuse (Disease Ontology:DOID:11206); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); temporal lobe epilepsy (Disease Ontology:DOID:3328); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29625); (R-RNO-373080)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "1846945", "class_list": "", "function": "Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy., [UniProtKB, UniProtKB, UniProtKB]; Specifically binds and inactivates the corticotropin-releasing hormone (CRH) and urocortin-1 (UCN) hormones, thereby inhibiting the hypothalamus-pituitary-adrenal axis and preventing corticotropin hormone (ACTH) production (PubMed:1846945). May be required to prevent inappropriate pituitary-adrenal stimulation in pregnancy (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042277 peptide binding;GO:0051424 corticotropin-releasing hormone binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030141 secretory granule", "go_biological_process": "GO:0002125 maternal aggressive behavior;GO:0035903 cellular response to immobilization stress;GO:0001659 temperature homeostasis;GO:0006954 inflammatory response;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P24388-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05432-1", "uniprot_id": "ERRFI_RAT", "mass": 49941.0, "length": 459, "protein_name": "ERBB receptor feedback inhibitor 1", "gene_name": "Errfi1", "organism": "Rat", "refseq_name": "ERBB receptor feedback inhibitor 1", "refseq_ac": "NP_001014093", "gene_names_uniprotkb": "Errfi1; 33; Mig6", "gene_names_refseq": "Errfi1; RGD1307599; Ralt; Xxx; gene 33", "protein_names_uniprotkb": "ERBB receptor feedback inhibitor 1; Gene 33 polypeptide; MIG-6; Mitogen-inducible gene 6 protein homolog; RALT; Receptor-associated late transducer", "protein_names_refseq": "ERBB receptor feedback inhibitor 1; gene 33 polypeptide; mig-6; mitogen-inducible gene 6 protein homolog; receptor-associated late transducer", "tax_id": 10116, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); endometrial cancer (Disease Ontology:DOID:1380); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:313729)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11003669;17599051;22673903;23384834;23432726;27358163;2780291;2916834;30597234;3224831", "class_list": "", "function": "Chk1 plays a role in regulating RALT protein stability by facilitating the interaction between 14-3-3 and RALT., [RefSeq, PubMed]; Findings thus suggest that the stimulation of Errfi1 and Ifrd1 may be important for theca and granulosa cell differentiation and oocyte complexes expansion., [RefSeq, PubMed]; MIG-6/RALT is a transcriptionally controlled inhibitor of mitogenic and transforming signals generated by the ErbB-2 oncogene. MIG-6/RALT forms a physical complex with activated ErbB-2 and co-localizes with ErbB-2 in living cells., [RefSeq, PubMed]; Mig6 functions as a molecular brake for beta-cell proliferation during glucocorticoid treatment in beta-cells, and thus, Mig6 may be a novel target for preventing glucocorticoid-induced impairments in functional beta-cell mass., [RefSeq, PubMed]; Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity)., [UniProtKB, PubMed, PubMed]; Results showed that miR-126 could inhibit apoptosis and reactive oxygen species accumulation by targeting ERRFI1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0019900 kinase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0060429 epithelium development;GO:0001889 liver development;GO:0006468 protein phosphorylation;GO:0006629 lipid metabolic process;GO:0006699 bile acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P05432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05503-1", "uniprot_id": "COX1_RAT", "mass": 56845.0, "length": 514, "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "Mt-co1", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit I", "refseq_ac": "YP_665631", "gene_names_uniprotkb": "Mt-co1; Coi; Mtco1", "gene_names_refseq": "COI; COX1", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 1; 7.1.1.9; Cytochrome c oxidase polypeptide I", "protein_names_refseq": "cytochrome c oxidase subunit I", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:26195); (R-RNO-5419276); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564); (R-RNO-9837999)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "1664046;19004814;23132757;2504926;27213235;6300770", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.29;7.1.1.9;7.1.1.2", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0001666 response to hypoxia;GO:0045907 positive regulation of vasoconstriction;GO:0046688 response to copper ion;GO:0051602 response to electrical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P05503-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07308-1", "uniprot_id": "ACOD1_RAT", "mass": 41467.0, "length": 358, "protein_name": "Acyl-CoA desaturase 1", "gene_name": "Scd1", "organism": "Rat", "refseq_name": "acyl-CoA desaturase 1", "refseq_ac": "NP_631931", "gene_names_uniprotkb": "Scd1; Scd", "gene_names_refseq": "Scd1; Scd", "protein_names_uniprotkb": "Acyl-CoA desaturase 1; 1.14.19.1; Delta(9)-desaturase 1; Delta-9 desaturase 1; Fatty acid desaturase 1; Stearoyl-CoA desaturase 1", "protein_names_refseq": "acyl-CoA desaturase 1; delta(9)-desaturase 1; fatty acid desaturase 1; stearoyl-CoA desaturase 1; stearoyl-Coenzyme A desaturase 1", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); hyperinsulinism (Disease Ontology:DOID:2018); carcinoma (Disease Ontology:DOID:305); restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": " (rno:246074); (R-RNO-75105)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12419843;1982442;2428815;2892838;32048626;38114435;7947684", "class_list": "", "function": "Feeding of VAD diet either alone or under HFr condition increased the kidney oleic acid (C18:1) levels and thus total MUFA, which corroborated with elevated SCD1 activity index, without affecting its expression status, [RefSeq, PubMed]; Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPbeta- SCD activation in non-alcoholic fatty liver disease., [RefSeq, PubMed]; Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:2892838, PubMed:7947684). Catalyzes the insertion of a cis double bond at the Delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:2892838, PubMed:7947684). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (PubMed:7947684). Required for normal development of sebaceous glands. Required for the biosynthesis of normal levels of Delta-9 unsaturated fatty acids and 1-alkyl-2,3-diacylglycerol in the Harderian gland. Required for normal production of meibum, an oily material that prevents drying of the cornea (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZL5", "ec_number_list": "1.14.19.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0046872 metal ion binding;GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0016491 oxidoreductase activity;GO:0032896 palmitoyl-CoA 9-desaturase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0048733 sebaceous gland development;GO:0006641 triglyceride metabolic process;GO:0007584 response to nutrient;GO:0008610 lipid biosynthetic process;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P07308-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07896-1", "uniprot_id": "ECHP_RAT", "mass": 78658.0, "length": 722, "protein_name": "Peroxisomal bifunctional enzyme", "gene_name": "Ehhadh", "organism": "Rat", "refseq_name": "peroxisomal bifunctional enzyme", "refseq_ac": "NP_598290", "gene_names_uniprotkb": "Ehhadh; Mfe1", "gene_names_refseq": "Ehhadh; Lbp; MEF; MFP1; Mfe1; Mfe; Pbe; Pbfe; pe-CoA; perMFE-1", "protein_names_uniprotkb": "Peroxisomal bifunctional enzyme; MFE1; MFP1; Multifunctional enzyme 1; Multifunctional protein 1; PBE; PBFE", "protein_names_refseq": "L-specific bifunctional protein; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; multifunctional enzyme 1; multifunctional enzyme type 1; multifunctional protein 1; peroxisomal bifunctional enzyme type 1; peroxisomal bifunctional enzyme; peroxisomal enoyl-CoA/hydrotase-3-hydroxyacyl-CoA", "tax_id": 10116, "disease": "Fanconi renotubular syndrome 3 (Disease Ontology:DOID:0080759)", "pathway": " (rno:171142); (R-RNO-390247); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11781327;12106015;16330050;20463028;2303409;23351063;3036802;38458818;4019459;8856068", "class_list": "", "function": "Data from crystallographic binding studies suggest that a catalytic water molecule, bound between two catalytic glutamates (Glu103/Glu123), plays important role in enoyl-CoA isomerase and enoyl-CoA hydratase reaction mechanisms of MFE1., [RefSeq, PubMed]; Liganded rat peroxisomal multifunctional enzyme type 1 is a flexible molecule with two interconnected active sites [rpMFE1], [RefSeq, PubMed]; Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities (PubMed:12106015, PubMed:2303409, PubMed:23351063). Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway (PubMed:12106015, PubMed:2303409). Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (Probable). Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species. Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (PubMed:11781327). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Structural enzymology studies with the substrate 3S-hydroxybutanoyl-CoA: bifunctional MFE1 is a less efficient dehydrogenase than monofunctional HAD., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBD2", "ec_number_list": "1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;4.2.1.17;5.3.3.8;1.1.1.211;2.3.1.-", "go_molecular_function": "GO:0016509 long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity;GO:0019899 enzyme binding;GO:0070403 NAD+ binding;GO:0004300 enoyl-CoA hydratase activity;GO:0018812 3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P07896-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08911-1", "uniprot_id": "ACM5_RAT", "mass": 60137.0, "length": 531, "protein_name": "Muscarinic acetylcholine receptor M5", "gene_name": "Chrm5", "organism": "Rat", "refseq_name": "muscarinic acetylcholine receptor M5", "refseq_ac": "NP_059058", "gene_names_uniprotkb": "Chrm5; Chrm-5", "gene_names_refseq": "Chrm5", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M5", "protein_names_refseq": "muscarinic acetylcholine receptor M5", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); alcohol use disorder (Disease Ontology:DOID:1574); cannabis dependence (Disease Ontology:DOID:1849)", "pathway": " (rno:53949); (R-RNO-390648); (R-RNO-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12433399;22095037;23504804;2380182;24866457;2540186;3272174", "class_list": "", "function": "M5 receptor is the major muscarinic receptor subtype in rat adrenal medullary cells and may be involved in neuronal transmission under conditions where acetylcholine spills over the synapse, [RefSeq, PubMed]; The m1-m5 muscarinic subtypes mapped to the following chromosomes: Chrm1, chromosome 1; Chrm2, chromosome 4; Chrm3, chromosome 17; Chrm4, chromosome 3; and Chrm5, chromosome 3., [RefSeq, PubMed]; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover., [UniProtKB]; The relative mRNA expression of M3 and M5 mAChR in bones of a rat osteoporosis model, was investigated. Publication Status: Online-Only, [RefSeq, PubMed]; This study demonistrted that Somatodendritic targeting of M5 muscarinic receptor in the rat ventral tegmental area: implications for mesolimbic dopamine transmission., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0001696 gastric acid secretion;GO:0015872 dopamine transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P08911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09759-1", "uniprot_id": "EPHB1_RAT", "mass": 109883.0, "length": 984, "protein_name": "Ephrin type-B receptor 1", "gene_name": "Ephb1; Ephb2", "organism": "Rat", "refseq_name": "ephrin type-B receptor 1 precursor", "refseq_ac": "NP_001097998", "gene_names_uniprotkb": "Ephb1; Ephb2; Elk; Epth2", "gene_names_refseq": "Ephb1; Ephb2; Erk; elk", "protein_names_uniprotkb": "Ephrin type-B receptor 1; 2.7.10.1; ELK; Tyrosine-protein kinase receptor EPH-2", "protein_names_refseq": "Eph receptor B2 (ELK-related protein tyrosine kinase); ephrin type-B receptor 1 precursor; ephrin type-B receptor 1; tyrosine-protein kinase receptor EPH-2", "tax_id": 10116, "disease": "aortic dissection (Disease Ontology:DOID:0080685); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); cognitive disorder (Disease Ontology:DOID:1561); blood platelet disease (Disease Ontology:DOID:2218); middle cerebral artery infarction (Disease Ontology:DOID:3525); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); ulcerative colitis (Disease Ontology:DOID:8577); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:24338); (R-RNO-2682334); (R-RNO-3928662); (R-RNO-3928664); (R-RNO-3928665)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "2017163;22673903;2485255;33356837;33678127;35623546;36918107;38843836", "class_list": "", "function": "Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression., [RefSeq, PubMed]; Corticosterone injection into the infralimbic prefrontal cortex enhances fear memory extinction: Involvement of GABA receptors and the extracellular signal-regulated kinase., [RefSeq, PubMed]; Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively (By similarity). Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.10.2;4.2.1.1;2.7.12.2;2.7.1.40;2.7.11.1;3.4.23.-;2.7.11.13;3.6.5.2;2.7.10.4;3.4.24.24;3.4.24.35;3.6.4.-;2.7.1.32;2.7.1.82;2.7.11.23", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0008046 axon guidance receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0021545 cranial nerve development;GO:0021934 hindbrain tangential cell migration;GO:0001525 angiogenesis;GO:0048013 ephrin receptor signaling pathway;GO:0050965 detection of temperature stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P09759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C0K7-1", "uniprot_id": "EPHB6_RAT", "mass": 110313.0, "length": 1013, "protein_name": "Ephrin type-B receptor 6", "gene_name": "Ephb6", "organism": "Rat", "refseq_name": "ephrin type-B receptor 6 precursor", "refseq_ac": "NP_001101327", "gene_names_uniprotkb": "Ephb6", "gene_names_refseq": "Ephb6", "protein_names_uniprotkb": "Ephrin type-B receptor 6; Tyrosine-protein kinase-defective receptor EPH-6", "protein_names_refseq": "ephrin type-B receptor 6 precursor; ephrin type-B receptor 6; serine/arginine repetitive matrix protein 2-like; tyrosine-protein kinase-defective receptor EPH-6", "tax_id": 10116, "disease": "", "pathway": " (rno:312275); (R-RNO-2682334); (R-RNO-3928662); (R-RNO-3928664); (R-RNO-3928665)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Can recruit SH2 domain-containing signaling adapters following phosphorylation by EPHB4., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0050798 activated T cell proliferation;GO:0007411 axon guidance;GO:0001806 type IV hypersensitivity;GO:0002456 T cell mediated immunity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C0K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2X9-1", "uniprot_id": "AL4A1_RAT", "mass": 61869.0, "length": 563, "protein_name": "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial", "gene_name": "Aldh4a1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Aldh4a1", "gene_names_refseq": "", "protein_names_uniprotkb": "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; 1.2.1.88; Aldehyde dehydrogenase family 4 member A1; L-glutamate gamma-semialdehyde dehydrogenase; P5C dehydrogenase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-389661); (R-RNO-70688)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.2.1.88", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0003842 L-glutamate gamma-semialdehyde dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010133 L-proline catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C2X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C5E9-1", "uniprot_id": "CRYGS_RAT", "mass": 20942.0, "length": 178, "protein_name": "Gamma-crystallin S", "gene_name": "Crygs", "organism": "Rat", "refseq_name": "gamma-crystallin S", "refseq_ac": "NP_001103023", "gene_names_uniprotkb": "Crygs", "gene_names_refseq": "Crygs", "protein_names_uniprotkb": "Gamma-crystallin S; Beta-crystallin S; Gamma-S-crystallin", "protein_names_refseq": "beta-crystallin S; gamma-S-crystallin; gamma-crystallin S", "tax_id": 10116, "disease": "cataract 20 multiple types (Disease Ontology:DOID:0110240)", "pathway": " (rno:689897)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002009 morphogenesis of an epithelium;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C5E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C6T1-1", "uniprot_id": "CTF8_RAT", "mass": 13328.0, "length": 121, "protein_name": "Chromosome transmission fidelity protein 8 homolog", "gene_name": "Chtf8", "organism": "Rat", "refseq_name": "chromosome transmission fidelity protein 8 homolog", "refseq_ac": "NP_001181880", "gene_names_uniprotkb": "Chtf8; Ctf8", "gene_names_refseq": "Chtf8; Ctf8; Derpc; RGD1306894", "protein_names_uniprotkb": "Chromosome transmission fidelity protein 8 homolog", "protein_names_refseq": "CTF8, chromosome transmission fidelity factor 8 homolog; chromosome transmission fidelity factor 8 homolog; chromosome transmission fidelity protein 8 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:364996); (R-RNO-174411)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0031390 Ctf18 RFC-like complex", "go_biological_process": "GO:0006260 DNA replication;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C6T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CD95-1", "uniprot_id": "CQ067_RAT", "mass": 10628.0, "length": 90, "protein_name": "Uncharacterized protein C17orf67 homolog", "gene_name": "C10h17orf67", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "C10h17orf67; LOC688126", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein C17orf67 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:688126)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0CD95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CF24-1", "uniprot_id": "FOXP2_RAT", "mass": 79236.0, "length": 710, "protein_name": "Forkhead box protein P2", "gene_name": "Foxp2", "organism": "Rat", "refseq_name": "forkhead box protein P2 isoform 1", "refseq_ac": "NP_001258033", "gene_names_uniprotkb": "Foxp2", "gene_names_refseq": "Foxp2; RGD1559697", "protein_names_uniprotkb": "Forkhead box protein P2", "protein_names_refseq": "Forkhead box protein P2; forkhead box protein P2 isoform 1", "tax_id": 10116, "disease": "specific developmental disorder (Disease Ontology:DOID:0060038); autism spectrum disorder (Disease Ontology:DOID:0060041); speech-language disorder-1 (Disease Ontology:DOID:0111275); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); autistic disorder (Disease Ontology:DOID:12849); major depressive disorder (Disease Ontology:DOID:1470); articulation disorder (Disease Ontology:DOID:4186); dyslexia (Disease Ontology:DOID:4428); schizophrenia (Disease Ontology:DOID:5419); language disorder (Disease Ontology:DOID:93)", "pathway": " (rno:500037)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "24179158;29414420;31545395;31887421;36722214;36766852", "class_list": "", "function": "Increased Nuclear FOXP2 Is Related to Reduced Neural Stem Cell Number and Increased Neurogenesis in the Dorsal Telencephalon of Embryos of Diabetic Rats through Histamine H1 Receptors. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA TTN-AS1 exacerbates extracellular matrix accumulation via miR-493-3p/FOXP2 axis in diabetic nephropathy., [RefSeq, PubMed]; LncRNA XIST attenuates hypoxia-induced H9c2 cardiomyocyte injury by targeting the miR-122-5p/FOXP2 axis., [RefSeq, PubMed]; The miR1345p/Foxp2/Syn1 axis was found to contribute to cognitive impairment in a chronic ischemiainduced early VD model, which may enable the development of new therapeutic strategies for the prevention and treatment of VD., [RefSeq, PubMed]; The results of this study showed that FOXP2 expression in respiratory brainstem areas selectively delineates laryngeal and hypoglossal pre-motor neuron populations., [RefSeq, PubMed]; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays a role in synapse formation by regulating SRPX2 levels., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development;GO:0048286 lung alveolus development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0CF24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CH38-1", "uniprot_id": "FBSP1_RAT", "mass": 25759.0, "length": 230, "protein_name": "F-box/SPRY domain-containing protein 1", "gene_name": "Fbxo45", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fbxo45", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box/SPRY domain-containing protein 1; F-box only protein 45", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:288042)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19996097", "class_list": "", "function": "Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1. Functions in substrate recognition but plays also an important role in assembly of the complex (By similarity). Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (PubMed:19996097). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. Polyubiquitinates NMNAT2, an adenylyltransferase that acts as an axon maintenance factor, and regulates its stability and degradation by the proteasome. Also acts by ubiquitinating FBXW7 during prolonged mitotic arrest and promotes FBXW7 proteasomal degradation. Induces subsequently an increase in mitotic slippage and prevents mitotic cell death. In response to influenza infection, mediates interferon-lambda receptor IFNLR1 polyubiquitination and degradation through the ubiquitin-proteasome system by docking with its intracellular receptor domain (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:0060384 innervation;GO:0021799 cerebral cortex radially oriented cell migration;GO:0001764 neuron migration;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0CH38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10093-1", "uniprot_id": "CALCB_RAT", "mass": 14965.0, "length": 134, "protein_name": "Calcitonin gene-related peptide 2", "gene_name": "Calcb", "organism": "Rat", "refseq_name": "calcitonin gene-related peptide 2 isoform 1 precursor", "refseq_ac": "NP_612522", "gene_names_uniprotkb": "Calcb", "gene_names_refseq": "CGRP-II; CGRP2; Calcb", "protein_names_uniprotkb": "Calcitonin gene-related peptide 2; Beta-type CGRP; CGRP-II; CGRP2; Calcitonin gene-related peptide II", "protein_names_refseq": "beta-type CGRP; calcitonin gene-related peptide 2 isoform 1 precursor; calcitonin gene-related peptide 2; calcitonin gene-related peptide II", "tax_id": 10116, "disease": "", "pathway": " (rno:171519); (R-RNO-419812)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12297551;2994212", "class_list": "", "function": "CALCB/CGRP2 is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role., [UniProtKB, UniProtKB]; Results indicate that calcitonin gene-related peptide-B receptors are present in rat placenta and that receptor levels are higher with gestational age and lower at term labor (Calcb) Erratum:[Biol Reprod. 2002 Dec;67(6):1996.], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031716 calcitonin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0051480 regulation of cytosolic calcium ion concentration;GO:1990408 calcitonin gene-related peptide receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P10093-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10610-1", "uniprot_id": "CP2G1_RAT", "mass": 56781.0, "length": 494, "protein_name": "Cytochrome P450 2G1", "gene_name": "Cyp2g1", "organism": "Rat", "refseq_name": "cytochrome P450 2G1", "refseq_ac": "NP_036919", "gene_names_uniprotkb": "Cyp2g1; Cyp2g-1", "gene_names_refseq": "CYPIIG1; Cyp2g1; P-450olf1; P450-OLF1", "protein_names_uniprotkb": "Cytochrome P450 2G1; 1.14.14.1; CYPIIG1; Cytochrome P450 olfactive; Cytochrome P450-OLF1", "protein_names_refseq": "Cytochrome P450, an olfactory-specific steroid hydroxylase; cytochrome P-450; cytochrome P450 2G1; cytochrome P450 olfactive; cytochrome P450, subfamily 2G, polypeptide 1; cytochrome P450-OLF1", "tax_id": 10116, "disease": "", "pathway": " (rno:25251)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2406242;2708343", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases., [UniProtKB, UniProtKB]; Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64589", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0007608 sensory perception of smell;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P10610-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10716-1", "uniprot_id": "CLC4F_RAT", "mass": 61104.0, "length": 550, "protein_name": "C-type lectin domain family 4 member F", "gene_name": "Clec4f", "organism": "Rat", "refseq_name": "C-type lectin domain family 4 member F", "refseq_ac": "NP_446205", "gene_names_uniprotkb": "Clec4f; Clecsf13; Kclr", "gene_names_refseq": "Clec4f; Clecsf13; Kclr", "protein_names_uniprotkb": "C-type lectin domain family 4 member F; C-type lectin 13; C-type lectin superfamily member 13; Kupffer cell receptor", "protein_names_refseq": "C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13; C-type lectin 13; C-type lectin domain family 4 member F; C-type lectin superfamily member 13; Kupffer cell receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:114598)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12672702;1846367;2836387", "class_list": "", "function": "Receptor with an affinity for galactose and fucose. Could be involved in endocytosis., [UniProtKB]; The receptor displays monosaccharide-binding characteristics similar to the hepatic asialoglycoprotein receptor, but with somewhat less selectivity, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q4KMB0", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038187 pattern recognition receptor activity;GO:0005534 galactose binding;GO:0051861 glycolipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P10716-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10980-1", "uniprot_id": "ACM2_RAT", "mass": 51539.0, "length": 466, "protein_name": "Muscarinic acetylcholine receptor M2", "gene_name": "Chrm2", "organism": "Rat", "refseq_name": "muscarinic acetylcholine receptor M2", "refseq_ac": "NP_112278", "gene_names_uniprotkb": "Chrm2; Chrm-2", "gene_names_refseq": "Acm2; Chrm2", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M2", "protein_names_refseq": "7TM receptor; M2 muscarinic acetylcholine receptor; cholinergic receptor, muscarinic 2, cardiac; muscarinic acetylcholine receptor M2-like; muscarinic acetylcholine receptor M2; muscarinic receptor m2", "tax_id": 10116, "disease": "Chagas disease (Disease Ontology:DOID:12140); major depressive disorder (Disease Ontology:DOID:1470); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:81645); (R-RNO-390648); (R-RNO-418594); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "22673903;26086781;26475745;2825184;29227527;34370080;7539085;9972520", "class_list": "", "function": "Data suggest that levels of CHRM2 are lower in Brodmann's area 24 from subjects with mood disorders, and it is possible that signalling by that receptor is also less in this cortical region; increasing levels of CHRM2 may be involved in the mechanisms of action of mood stabilisers and tricyclic antidepressants Publication Status: Online-Only, [RefSeq, PubMed]; Long-term stimulation with autoantibodies against M2 muscarinic receptor leaded to the ventricular dilatation and gradual deterioration of cardiac dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our results indicate that Acetylcholine (ACh) via M2 receptors, may contribute to the maintaining of the ADSCs quiescent status. These data are the first evidence that ACh, via muscarinic receptors, might contribute to control Mesenchymal stem cell derived from Adipose tissue physiology., [RefSeq, PubMed]; Reduced acetylcholine and elevated muscarinic receptor 2 in duodenal mucosa contribute to the impairment of mucus secretion in 6-hydroxydopamine-induced Parkinson's disease rats., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z2Z1", "ec_number_list": "", "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity;GO:1990763 arrestin family protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0032279 asymmetric synapse", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10980-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11240-1", "uniprot_id": "COX5A_RAT", "mass": 16130.0, "length": 146, "protein_name": "Cytochrome c oxidase subunit 5A, mitochondrial", "gene_name": "Cox5a; LOC100361008", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 5A, mitochondrial precursor", "refseq_ac": "NP_665726", "gene_names_uniprotkb": "Cox5a; LOC100361008; LOC100361008", "gene_names_refseq": "Cox5a", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 5A, mitochondrial; Cytochrome c oxidase polypeptide Va", "protein_names_refseq": "cytochrome c oxidase polypeptide Va; cytochrome c oxidase subunit 5A, mitochondrial precursor; cytochrome c oxidase subunit 5A, mitochondrial; cytochrome c oxidase, subunit Va", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); ciliopathy (Disease Ontology:DOID:0060340); mitochondrial complex IV deficiency nuclear type 20 (Disease Ontology:DOID:0070505); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (rno:100361008); (rno:252934); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564); (R-RNO-9837999)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "20966424;25436770;2544858;26446791;32349668;34518647;7601105", "class_list": "", "function": "COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MicroRNA-26a/b-5p promotes myocardial infarction-induced cell death by downregulating cytochrome c oxidase 5a., [RefSeq, PubMed]; Novel observations indicate that Cox5a hypermethylation is associated with mitochondrial dysfunction in skeletal muscle of high-fat diet-induced insulin resistant rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P11240-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11475-1", "uniprot_id": "ERR2_RAT", "mass": 48288.0, "length": 433, "protein_name": "Steroid hormone receptor ERR2", "gene_name": "Esrrb", "organism": "Rat", "refseq_name": "steroid hormone receptor ERR2", "refseq_ac": "NP_001008516", "gene_names_uniprotkb": "Esrrb; Err2; Esrl2; Nr3b2", "gene_names_refseq": "Err2; Errb; Esrrb", "protein_names_uniprotkb": "Steroid hormone receptor ERR2; ERR-beta; Estrogen receptor-like 2; Estrogen-related receptor beta; Nuclear receptor subfamily 3 group B member 2", "protein_names_refseq": "ERR-beta; estrogen receptor-like 2; nuclear receptor subfamily 3 group B member 2; steroid hormone receptor ERR2", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 35 (Disease Ontology:DOID:0110493); dilated cardiomyopathy (Disease Ontology:DOID:12930); azoospermia (Disease Ontology:DOID:14227); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:299210); (R-RNO-383280)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10072763;25737630;3267207", "class_list": "", "function": "Daily regulation of Esrrb in photoreceptor cells may contribute to their adaptation to 24-h changes in metabolic demands. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (By similarity). Plays a role, in a LIF independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Involved in morula development (2-16 cells embryos) by acting as a regulator at the 8-cell stage (By similarity). Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (By similarity). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (By similarity). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5QJB1", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000793 condensed chromosome;GO:0000785 chromatin", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P11475-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13107-1", "uniprot_id": "CP2B3_RAT", "mass": 56384.0, "length": 491, "protein_name": "Cytochrome P450 2B3", "gene_name": "Cyp2b3", "organism": "Rat", "refseq_name": "cytochrome P450 2B3 precursor", "refseq_ac": "NP_775416", "gene_names_uniprotkb": "Cyp2b3; Cyp2b-3", "gene_names_refseq": "CYPIIB3; Cyp2b3; Cyp2b6", "protein_names_uniprotkb": "Cytochrome P450 2B3; 1.14.14.1; CYPIIB3", "protein_names_refseq": "cytochrome P450 2B3 precursor; cytochrome P450 2B3-like; cytochrome P450 2B3; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6; cytochrome P450IIB3", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute myeloid leukemia (Disease Ontology:DOID:9119); neonatal abstinence syndrome (Disease Ontology:DOID:9828); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:286953)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "3013548;3396451", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L121;Q3B8R5;Q64585", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042180 ketone metabolic process;GO:1904010 response to Aroclor 1254;GO:0009617 response to bacterium;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P13107-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13803-1", "uniprot_id": "ETFA_RAT", "mass": 34951.0, "length": 333, "protein_name": "Electron transfer flavoprotein subunit alpha, mitochondrial", "gene_name": "Etfa", "organism": "Rat", "refseq_name": "electron transfer flavoprotein subunit alpha, mitochondrial", "refseq_ac": "NP_001009668", "gene_names_uniprotkb": "Etfa", "gene_names_refseq": "ETF; Etfa", "protein_names_uniprotkb": "Electron transfer flavoprotein subunit alpha, mitochondrial; Alpha-ETF", "protein_names_refseq": "alpha-ETF; electron transfer flavoprotein alpha subunit; electron transfer flavoprotein subunit alpha, mitochondrial; electron transferring flavoprotein, alpha polypeptide; electron-transfer-flavoprotein, alpha polypeptide", "tax_id": 10116, "disease": "multiple acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0060358)", "pathway": " (rno:300726); (R-RNO-611105)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22673903;26446791;27213235;3415685;34502162;7334008", "class_list": "", "function": "Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:7334008). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5M7W0", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0050660 flavin adenine dinucleotide binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045251 electron transfer flavoprotein complex", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0022904 respiratory electron transport chain;GO:0009063 amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P13803-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14408-1", "uniprot_id": "FUMH_RAT", "mass": 54465.0, "length": 507, "protein_name": "Fumarate hydratase, mitochondrial", "gene_name": "Fh", "organism": "Rat", "refseq_name": "fumarate hydratase, mitochondrial precursor", "refseq_ac": "NP_058701", "gene_names_uniprotkb": "Fh; Fh1", "gene_names_refseq": "Fh1; Fh", "protein_names_uniprotkb": "Fumarate hydratase, mitochondrial; 4.2.1.2; Fumarase", "protein_names_refseq": "fumarase; fumarate hydratase 1; fumarate hydratase, mitochondrial precursor; fumarate hydratase, mitochondrial", "tax_id": 10116, "disease": "fumarase deficiency (Disease Ontology:DOID:0111261); lung non-small cell carcinoma (Disease Ontology:DOID:3908); leiomyomatosis (Disease Ontology:DOID:5138)", "pathway": " (rno:24368); (R-RNO-71403); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "2914923;29393594;31235845;33755527", "class_list": "", "function": "Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH., [UniProtKB, UniProtKB]; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable)., [UniProtKB, UniProtKB]; Insufficient fumarase contributes to hypertension by an imbalance of redox metabolism in Dahl salt-sensitive rats., [RefSeq, PubMed]; Perinatal undernourishment provokes long-lasting alterations of clusterin and fumarate hydratase expression in the rat nucleus accumbens., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5M964", "ec_number_list": "6.1.1.5;1.3.8.5;6.2.1.4;4.98.1.1;5.6.2.3;2.8.3.5;2.3.1.-;2.3.1.41;3.4.21.92;3.5.3.1;3.1.2.2;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.2.-;1.1.1.37;6.4.1.3;7.1.2.2;1.4.1.3;1.2.1.3;2.3.1.37;4.2.1.2;2.3.1.9;2.3.3.10;5.3.3.8;1.1.1.30;3.6.4.10;1.2.4.1;1.1.1.42;5.6.1.7;1.3.8.1;2.7.1.23;1.2.4.2;5.3.3.21;2.7.11.2;2.7.11.-;7.1.1.2;1.2.1.36;1.7.1.-;1.2.1.28;1.8.1.4;2.3.3.1;3.4.21.53;1.1.1.41;4.2.1.3", "go_molecular_function": "GO:0004333 fumarate hydratase activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0035861 site of double-strand break", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006106 fumarate metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006281 DNA repair;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P14408-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14604-1", "uniprot_id": "ECHM_RAT", "mass": 31516.0, "length": 290, "protein_name": "Enoyl-CoA hydratase, mitochondrial", "gene_name": "Echs1", "organism": "Rat", "refseq_name": "enoyl-CoA hydratase, mitochondrial precursor", "refseq_ac": "NP_511178", "gene_names_uniprotkb": "Echs1", "gene_names_refseq": "Echs1; mECH1; mECH", "protein_names_uniprotkb": "Enoyl-CoA hydratase, mitochondrial; 4.2.1.17; 5.3.3.8; ECHS1; Enoyl-CoA hydratase 1; SCEH; Short-chain enoyl-CoA hydratase; mECH1; mECH", "protein_names_refseq": "Enoyl-CoA hydratase, short chain 1, mitochondrial; SCEH; enoyl CoA hydratase, short chain, 1, mitochondrial; enoyl Coenzyme A hydratase, short chain 1; enoyl Coenzyme A hydratase, short chain, 1, mitochondrial; enoyl-CoA hydratase 1; enoyl-CoA hydratase, mitochondrial precursor; enoyl-CoA hydratase, mitochondrial-like; enoyl-CoA hydratase, mitochondrial; mitochondrial short-chain enoyl-coenzyme A hydratase 1; short-chain enoyl-CoA hydratase", "tax_id": 10116, "disease": "mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (Disease Ontology:DOID:0070540); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:140547); (R-RNO-70895); (R-RNO-77310); (R-RNO-77346); (R-RNO-77348); (R-RNO-77350); (R-RNO-77352)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "10074351;11851409;12445775;20162621;26446791;27213235;2806264;34502162;7883013;8895557;9480773", "class_list": "", "function": "Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding 3(S)-3-hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:10074351, PubMed:7883013). Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (PubMed:10074351, PubMed:7883013). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (By similarity). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation (PubMed:7883013). At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (PubMed:10074351)., [UniProtKB, PubMed, UniProtKB, PubMed]; Enoyl-coenzyme a hydratase down-regulation exacerbates hepatic steatosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.18;4.2.1.56;1.1.1.35;4.2.1.17;5.3.3.8;1.1.1.211;2.3.1.-;4.2.1.-", "go_molecular_function": "GO:0004300 enoyl-CoA hydratase activity;GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity;GO:0120092 (2E)-butenoyl-CoA hydratase activity;GO:0043956 3-hydroxypropionyl-CoA dehydratase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006574 L-valine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P14604-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14630-1", "uniprot_id": "APOM_RAT", "mass": 21513.0, "length": 190, "protein_name": "Apolipoprotein M", "gene_name": "Apom", "organism": "Rat", "refseq_name": "apolipoprotein M precursor", "refseq_ac": "NP_062246", "gene_names_uniprotkb": "Apom", "gene_names_refseq": "Apom", "protein_names_uniprotkb": "Apolipoprotein M; Apo-M; ApoM; Protein Px", "protein_names_refseq": "apo-M; apolipoprotein M precursor; protein Px", "tax_id": 10116, "disease": "coronary artery disease (Disease Ontology:DOID:3393); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:55939); (R-RNO-975634)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15060004;2297521;23953565;26377577", "class_list": "", "function": "ApoM occurrence in urine may be considered to be a biomarker of acute renal injury., [RefSeq, PubMed]; Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBB9;Q9QXI9", "ec_number_list": "", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005543 phospholipid binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0034366 spherical high-density lipoprotein particle", "go_biological_process": "GO:0042157 lipoprotein metabolic process;GO:0033344 cholesterol efflux;GO:0034375 high-density lipoprotein particle remodeling;GO:0043691 reverse cholesterol transport;GO:0034380 high-density lipoprotein particle assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P14630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14881-1", "uniprot_id": "CRBA1_RAT", "mass": 25270.0, "length": 215, "protein_name": "Beta-crystallin A3", "gene_name": "Cryba1", "organism": "Rat", "refseq_name": "beta-crystallin A3", "refseq_ac": "NP_037188", "gene_names_uniprotkb": "Cryba1", "gene_names_refseq": "BA3A1C; Cryba1; beta-A3", "protein_names_uniprotkb": "Beta-crystallin A3", "protein_names_refseq": "beta-A3 crystallin; beta-crystallin A3", "tax_id": 10116, "disease": "age related macular degeneration 1 (Disease Ontology:DOID:0110014); cataract 10 multiple types (Disease Ontology:DOID:0110258); microphthalmia (Disease Ontology:DOID:10629); retinal detachment (Disease Ontology:DOID:5327); cataract (Disease Ontology:DOID:83); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (rno:25583)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11773034;2499686;25736717;26303524", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB]; Data show that strocytes deficient in betaA3/A1-crystallin protein exhibit altered levels of total and activated signal transducer and activator of transcription 3 (STAT3). Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that the disappearance of the betaA3/A1-crystallin protein and, in addition, down-regulation of the Nufip2 gene as a consequence of gene rearrangement causes the HiSER phenotype., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35237", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0006909 phagocytosis;GO:0007601 visual perception;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0032007 negative regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P14881-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15823-1", "uniprot_id": "ADA1B_RAT", "mass": 56586.0, "length": 515, "protein_name": "Alpha-1B adrenergic receptor", "gene_name": "Adra1b", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Adra1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-1B adrenergic receptor; Alpha-1B adrenoceptor; Alpha-1B adrenoreceptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (R-RNO-390696); (R-RNO-416476); (R-RNO-416482)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1706716;21454685;2156222;7989580;8406017", "class_list": "", "function": "Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C (By similarity). ADRA1B binds the catecholamine ligands norepinephrine and epinephrine (By similarity). Can also couple to G(14) and G(16) proteins (By similarity). Nuclear ADRA1B forms heterooligomers with ADRA1A to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. At the plasma membrane, ADRA1B interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q63215", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004937 alpha1-adrenergic receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0045818 negative regulation of glycogen catabolic process;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P15823-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16296-1", "uniprot_id": "FA9_RAT", "mass": 51808.0, "length": 462, "protein_name": "Coagulation factor IX", "gene_name": "F9", "organism": "Rat", "refseq_name": "coagulation factor IX precursor", "refseq_ac": "NP_113728", "gene_names_uniprotkb": "F9; Cf9", "gene_names_refseq": "F9", "protein_names_uniprotkb": "Coagulation factor IX; 3.4.21.22; Christmas factor", "protein_names_refseq": "Coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B); christmas factor; coagulation factor 9; coagulation factor IX precursor", "tax_id": 10116, "disease": "X-linked warfarin sensitivity (Disease Ontology:DOID:0080839); X-linked thrombophilia due to factor IX defect (Disease Ontology:DOID:0111899); hemophilia B (Disease Ontology:DOID:12259); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24946); (R-RNO-159740); (R-RNO-159763); (R-RNO-159782); (R-RNO-9769735); (R-RNO-9769739); (R-RNO-9769743); (R-RNO-9935598)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "20838739;2303254;25790442", "class_list": "", "function": "Data provide substantial evidence of a participation of fIX in the mechanisms regulating thrombosis prior to those regulating primary haemostasis., [RefSeq, PubMed]; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nitrophorin 2, a factor IX(a)-directed anticoagulant, is a potent and long-lasting inhibitor of arterial thrombosis with minor effects on haemostasis., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 3, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "F1M1M6", "ec_number_list": "4.1.1.90;3.4.21.34;3.4.21.22;3.4.21.75;3.4.21.6;3.4.21.21", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006508 proteolysis;GO:0007597 blood coagulation, intrinsic pathway;GO:0007596 blood coagulation;GO:0031638 zymogen activation;GO:0051239 regulation of multicellular organismal process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P16296-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16970-1", "uniprot_id": "ABCD3_RAT", "mass": 75316.0, "length": 659, "protein_name": "ATP-binding cassette sub-family D member 3", "gene_name": "Abcd3", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family D member 3", "refseq_ac": "NP_036936", "gene_names_uniprotkb": "Abcd3; Pmp70; Pxmp1", "gene_names_refseq": "Abcd3; PMP70; Pxmp1", "protein_names_uniprotkb": "ATP-binding cassette sub-family D member 3; 3.1.2.-; 7.6.2.-; 70 kDa peroxisomal membrane protein; PMP70", "protein_names_refseq": "70-kDa peroxisomal membrane protein; ATP-binding cassette sub-family D member 3; ATP-binding cassette, sub-family D (ALD), member 3; ATP-binding cassette, subfamily D (ALD), member 3; Peroxisomal membrane protein 1", "tax_id": 10116, "disease": "congenital bile acid synthesis defect 5 (Disease Ontology:DOID:0111066); adrenoleukodystrophy (Disease Ontology:DOID:10588); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (rno:25270); (R-RNO-1369062); (R-RNO-8980692); (R-RNO-9013106); (R-RNO-9603798)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10207018;10527525;11883951;1968461;28100784;29393594;38843836", "class_list": "", "function": "Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities (By similarity). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:10207018)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.-;7.6.2.-;2.7.11.1;2.7.11.13;1.14.14.18;2.3.2.27;2.3.2.36;1.2.1.3;1.2.1.94;3.6.5.2;3.6.4.-;3.1.4.4;7.4.2.-;2.7.11.39;3.1.2.2", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006699 bile acid biosynthetic process;GO:0006869 lipid transport;GO:0042760 very long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P16970-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18427-1", "uniprot_id": "FSHB_RAT", "mass": 14814.0, "length": 130, "protein_name": "Follitropin subunit beta", "gene_name": "Fshb", "organism": "Rat", "refseq_name": "follitropin subunit beta precursor", "refseq_ac": "NP_001007598", "gene_names_uniprotkb": "Fshb", "gene_names_refseq": "FSH-B; FSH-beta; Fshb", "protein_names_uniprotkb": "Follitropin subunit beta; FSH-B; FSH-beta; Follicle-stimulating hormone beta subunit; Follitropin beta chain", "protein_names_refseq": "follicle - stimulating hormone subunit beta; follicle stimulating hormone beta subunit; follicle stimulating hormone, beta polypeptide; follitropin beta chain; follitropin subunit beta precursor; follitropin subunit beta", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 24 without anosmia (Disease Ontology:DOID:0090088); amenorrhea (Disease Ontology:DOID:13938); severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (rno:25447); (R-RNO-209822); (R-RNO-375281)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "2504572;25635942;26853521;27030385;28402262;29534107;3155259", "class_list": "", "function": "GnRH stimulation of Fshb expression is dependent on miR-132/212 and involves a SIRT1-FOXO1 pathway., [RefSeq, PubMed]; Our results indicate that miR-21-3p and miR-433 can down-regulate the expression of FSHb by directly targeting the FSHb 3'UTR in rat primary pituitary cells., [RefSeq, PubMed]; Study in primary rat pituitary cells demonstrates that miR-186-5p regulates FSH secretion by directly targeting the FSHb 3' UTR. Publication Status: Online-Only, [RefSeq, PubMed]; The study uncovers a new role for AMH in regulating gonadotrope function and suggests that AMH participates in the postnatal elevation of FSH secretion in females. Publication Status: Online-Only, [RefSeq, PubMed]; The upstream region of Fshb is susceptible to unsaturated long-chain fatty acids, [RefSeq, PubMed]; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016913 follicle-stimulating hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016914 follicle-stimulating hormone complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0045780 positive regulation of bone resorption", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18427-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19132-1", "uniprot_id": "FRIH_RAT", "mass": 21127.0, "length": 182, "protein_name": "Ferritin heavy chain", "gene_name": "Fth1", "organism": "Rat", "refseq_name": "ferritin heavy chain", "refseq_ac": "NP_036980", "gene_names_uniprotkb": "Fth1; Fth", "gene_names_refseq": "Fth1; Fth", "protein_names_uniprotkb": "Ferritin heavy chain; 1.16.3.1; Ferritin H subunit", "protein_names_refseq": "Ferritin subunit H; ferritin H subunit; ferritin heavy chain; ferritin, heavy polypeptide 1", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734); hemochromatosis type 5 (Disease Ontology:DOID:0111031); candidiasis (Disease Ontology:DOID:1508); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:25319); (R-RNO-432722); (R-RNO-6798695); (R-RNO-917937)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "2827671;30046590;32959272;3478702;37661197;6546756", "class_list": "", "function": "FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson's Disease., [RefSeq, PubMed]; FTH1 gene expression did not affect mesenchymal stem cell differentiation into neurons and was not affected by neural differentiation Publication Status: Online-Only, [RefSeq, PubMed]; Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis (By similarity). Has ferroxidase activity (By similarity). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation., [UniProtKB, UniProtKB, UniProtKB]; The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.4;5.2.1.8;1.1.1.205;3.2.1.23;1.16.3.1;3.5.4.5;2.3.2.5;3.6.4.13;2.4.1.25;3.2.1.33;4.2.99.18;5.6.2.4;4.1.2.4;2.4.1.186;3.5.4.6;3.1.1.47;3.4.24.34;3.2.1.17;3.4.22.1;1.11.1.6;2.5.1.18;4.1.2.13;3.6.5.-;4.2.1.24;3.2.1.31;2.4.1.1;2.7.10.2;2.7.11.1;2.7.1.40;1.13.11.-;1.13.11.34;1.11.1.27;1.11.1.9;1.16.3.4;3.4.19.1;2.3.3.8;2.7.4.6;2.7.13.3;3.4.23.5;5.4.2.11;5.4.2.4;2.7.1.1;3.3.2.6;3.4.11.4;2.7.1.11;5.3.2.1;5.3.3.12;3.4.21.46;5.4.2.2;1.1.1.42;3.6.4.6;3.4.24.35;3.1.6.12;2.3.2.26;3.6.4.10;2.7.11.24;3.1.3.48;2.4.2.1;3.4.22.52;3.4.22.27;3.5.1.3;3.4.19.9;1.8.3.2;5.3.1.9;5.1.3.-;3.5.1.23;3.5.1.-;3.6.1.6;3.4.25.1;3.4.18.1;1.11.1.24", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0008198 ferrous iron binding;GO:0004322 ferroxidase activity;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome", "go_biological_process": "GO:0006955 immune response;GO:0008285 negative regulation of cell population proliferation;GO:0006879 intracellular iron ion homeostasis;GO:0048147 negative regulation of fibroblast proliferation;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P19132-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19139-1", "uniprot_id": "CSK21_RAT", "mass": 45073.0, "length": 391, "protein_name": "Casein kinase II subunit alpha", "gene_name": "Csnk2a1", "organism": "Rat", "refseq_name": "casein kinase II subunit alpha", "refseq_ac": "NP_446276", "gene_names_uniprotkb": "Csnk2a1", "gene_names_refseq": "Csnk2a1", "protein_names_uniprotkb": "Casein kinase II subunit alpha; 2.7.11.1; CK II alpha", "protein_names_refseq": "CK II alpha; casein kinase 2, alpha 1 polypeptide; casein kinase II subunit alpha; casein kinase II, alpha 1 polypeptide", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:116549); (R-RNO-1483191); (R-RNO-201688); (R-RNO-2514853); (R-RNO-445144); (R-RNO-6804756); (R-RNO-6814122); (R-RNO-8934903); (R-RNO-8939243); (R-RNO-8948751); (R-RNO-9768727); (R-RNO-9929491)", "pathway_count": 12, "publication_count": 9, "publication_id_list": "12191471;18683930;19330005;2752008;28927755;33065005;34502162;38843836;8173590", "class_list": "", "function": "A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase 2alpha Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration., [RefSeq, PubMed]; Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]., [RefSeq]; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Vascular smooth muscle protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKC1", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;2.3.2.27;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016605 PML body;GO:0000785 chromatin", "go_biological_process": "GO:1905818 regulation of chromosome separation;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P19139-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19328-1", "uniprot_id": "ADA2B_RAT", "mass": 50369.0, "length": 453, "protein_name": "Alpha-2B adrenergic receptor", "gene_name": "Adra2b", "organism": "Rat", "refseq_name": "alpha-2B adrenergic receptor", "refseq_ac": "NP_612514", "gene_names_uniprotkb": "Adra2b", "gene_names_refseq": "Adra2b", "protein_names_uniprotkb": "Alpha-2B adrenergic receptor; Alpha-2B adrenoceptor; Alpha-2B adrenoreceptor; Alpha-2BAR", "protein_names_refseq": "Adrenergic alpha2B- receptor class III; Adrenergic, alpha2B-, receptor class III; adrenergic receptor, alpha 2b; adrenergic, alpha-2B-, receptor; alpha-2B adrenergic receptor; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; alpha-2BAR", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24174); (R-RNO-390696); (R-RNO-392023); (R-RNO-418594); (R-RNO-418597)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "11891218;15213003;15993847;21357695;2158103;25407049;30929926;32340145;7755946", "class_list": "", "function": "Adra2b signaling is impaired in the cardiomyocytes of spontaneously hypertensive rats starting from 2 months old., [RefSeq, PubMed]; Alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation., [RefSeq, PubMed]; Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:15213003, PubMed:2158103). ADRA2B physiological agonists includes norepinephrine (PubMed:2158103)., [UniProtKB, PubMed, PubMed]; Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface, [RefSeq, PubMed]; Intraglomerular Monocyte/Macrophage Infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A2B Adenosine Receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Report specific roles of alpha2A - and alpha2B -, but not alpha2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63021;Q925E4", "ec_number_list": "", "go_molecular_function": "GO:0004938 alpha2-adrenergic receptor activity;GO:0051379 epinephrine binding;GO:0004935 adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001525 angiogenesis;GO:0003056 regulation of vascular associated smooth muscle contraction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P19328-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20291-1", "uniprot_id": "AL5AP_RAT", "mass": 18070.0, "length": 161, "protein_name": "Arachidonate 5-lipoxygenase-activating protein", "gene_name": "Alox5ap", "organism": "Rat", "refseq_name": "arachidonate 5-lipoxygenase-activating protein", "refseq_ac": "NP_058956", "gene_names_uniprotkb": "Alox5ap; Flap", "gene_names_refseq": "Alox5ap", "protein_names_uniprotkb": "Arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein", "protein_names_refseq": "5-lipoxygenase-activating protein FLAP; FLAP; MK-886-binding protein; arachidonate 5-lipoxygenase-activating protein", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); common cold (Disease Ontology:DOID:10459); sarcoidosis (Disease Ontology:DOID:11335); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); cerebral palsy (Disease Ontology:DOID:1969); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); cerebral infarction (Disease Ontology:DOID:3526); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); neuroblastoma (Disease Ontology:DOID:769); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29624); (R-RNO-2142688); (R-RNO-2142691); (R-RNO-2142700)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "2300172;2300173;24641614;29936999;30735559;31010302", "class_list": "", "function": "BRP-7 potently suppresses leukotriene biosynthesis by interacting with FLAP in rat pleurisy model, [RefSeq, PubMed]; Bexarotene Exerts Protective Effects Through Modulation of the Cerebral Vascular Smooth Muscle Cell Phenotypic Transformation by Regulating PPARgamma/FLAP/LTB4 After Subarachnoid Hemorrhage in Rats., [RefSeq, PubMed]; Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study results suggest that the association of ALOX5/ALOX5AP contributes to leukotriene-induced inflammation and predisposes the trauma and hemorrhagic shock rats to lung injury., [RefSeq, PubMed]; The time-dependent reorganization has been reported of both 5-LO and FLAP into higher-order assemblies or clusters in the process of leukotriene C4 biosynthesis on the nuclear envelope in response to cell activation via the IgE receptor. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RJL3", "ec_number_list": "", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004464 leukotriene-C4 synthase activity;GO:0008047 enzyme activator activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002675 positive regulation of acute inflammatory response;GO:0071277 cellular response to calcium ion;GO:0019370 leukotriene biosynthetic process;GO:0019372 lipoxygenase pathway;GO:0070207 protein homotrimerization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P20291-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20812-1", "uniprot_id": "CP2A3_RAT", "mass": 56510.0, "length": 494, "protein_name": "Cytochrome P450 2A3", "gene_name": "Cyp2a3", "organism": "Rat", "refseq_name": "cytochrome P450 2A3", "refseq_ac": "NP_036674", "gene_names_uniprotkb": "Cyp2a3; Cyp2a-3; Cyp2a3a", "gene_names_refseq": "Cyp2a3a; Cyp2a3; RATCYP2A3A", "protein_names_uniprotkb": "Cytochrome P450 2A3; 1.14.14.1; CYPIIA3; Coumarin 7-hydroxylase", "protein_names_refseq": "CYPIIA3; coumarin 7-hydroxylase; cytochrome P450 2A3; cytochrome P450, family 2, subfamily A, polypeptide 3a; cytochrome P450, subfamily IIA (phenobarbital-inducble)/ (cytochrome P450 IIA3)", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); warfarin resistance (Disease Ontology:DOID:0080665); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (rno:24299); (R-RNO-211935); (R-RNO-211981); (R-RNO-211999); (R-RNO-5423646)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "12167220;15123731;2388852;2751996", "class_list": "", "function": "CYP2A3 levels in the rat esophagus can be a determinant of its ability to metabolize carcinogen N-nitrosomethylbenzylamine in vivo, [RefSeq, PubMed]; CYP2a3 trans activation requires NFIA transcription factors, [RefSeq, PubMed]; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0035634 response to stilbenoid;GO:0019373 epoxygenase P450 pathway;GO:0009804 coumarin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20812-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21451-1", "uniprot_id": "EDNRB_RAT", "mass": 49455.0, "length": 442, "protein_name": "Endothelin receptor type B", "gene_name": "Ednrb", "organism": "Rat", "refseq_name": "endothelin receptor type B precursor", "refseq_ac": "NP_059029", "gene_names_uniprotkb": "Ednrb", "gene_names_refseq": "Ednra; Ednrb; Etb", "protein_names_uniprotkb": "Endothelin receptor type B; ET-BR; ET-B; Endothelin receptor non-selective type", "protein_names_refseq": "ET-BR; ET-B; endothelin B receptor; endothelin receptor non-selective type; endothelin receptor type B precursor", "tax_id": 10116, "disease": "ABCD syndrome (Disease Ontology:DOID:0050600); pycnodysostosis (Disease Ontology:DOID:0080038); Waardenburg syndrome type 4A (Disease Ontology:DOID:0110953); sensorineural hearing loss (Disease Ontology:DOID:10003); Hirschsprung's disease (Disease Ontology:DOID:10487); otitis media (Disease Ontology:DOID:10754); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); intracranial aneurysm (Disease Ontology:DOID:10941); megacolon (Disease Ontology:DOID:11372); asthma (Disease Ontology:DOID:2841); myocardial infarction (Disease Ontology:DOID:5844); lymphopenia (Disease Ontology:DOID:614); pulmonary hypertension (Disease Ontology:DOID:6432); hepatopulmonary syndrome (Disease Ontology:DOID:900); Waardenburg syndrome (Disease Ontology:DOID:9258); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:50672); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1312429;2175397;34600481;37348026;37349999;37901475;38166688;38843836;8371713", "class_list": "", "function": "Activation of ETAR and ETBR in myocardial tissue characterizes heart failure induced by experimental autoimmune myocarditis. Publication Status: Online-Only, [RefSeq, PubMed]; ET-1 receptor type B (ETBR) overexpression associated with ICAM-1 downregulation leads to inflammatory attenuation in experimental autoimmune myocarditis. Publication Status: Online-Only, [RefSeq, PubMed]; Elevated renal afferent nerve activity in a rat model of endothelin B receptor deficiency., [RefSeq, PubMed]; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]; Role of Brain Endothelin Receptor Type B (ETB) in the Regulation of Tyrosine Hydroxylase in the Olfactory Bulb of DOCA-Salt Hypertensive Rats., [RefSeq, PubMed]; Structural heart defects associated with ETB mutation, a cause of Hirschsprung disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004962 endothelin receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0017046 peptide hormone binding;GO:0031702 type 1 angiotensin receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007497 posterior midgut development;GO:0014043 negative regulation of neuron maturation;GO:0031620 regulation of fever generation;GO:0035645 enteric smooth muscle cell differentiation;GO:0048484 enteric nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P21451-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22086-1", "uniprot_id": "ADA2C_RAT", "mass": 49864.0, "length": 458, "protein_name": "Alpha-2C adrenergic receptor", "gene_name": "Adra2c", "organism": "Rat", "refseq_name": "alpha-2C adrenergic receptor", "refseq_ac": "NP_612515", "gene_names_uniprotkb": "Adra2c", "gene_names_refseq": "Adra2c", "protein_names_uniprotkb": "Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; Alpha-2CAR", "protein_names_refseq": "Adrenergic alpha2C- receptor class I; Adrenergic, alpha2C-, receptor class I; adrenergic receptor, alpha 2c; adrenergic, alpha-2C-, receptor; alpha-2 adrenergic receptor subtype C4; alpha-2C adrenergic receptor; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2CAR", "tax_id": 10116, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:24175); (R-RNO-390696); (R-RNO-392023); (R-RNO-400042); (R-RNO-418594); (R-RNO-418597); (R-RNO-5683826)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "15213003;1645350;1704126;1704314;21518261;21562737;22892388;25218984;25407049", "class_list": "", "function": "Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:15213003). ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; During the development of hypertension, adrenal alpha(2) -adrenoceptor inhibitory function is conserved, accompanied by reduced noradrenaline release and unchanged adrenaline release in spontaneously hypertensive rats., [RefSeq, PubMed]; In 6-OHDA-lesioned rats, there was no change in alpha2C adrenoceptor expression in the rostral or caudal striatum in which the highest density of alpha2C mRNA is present., [RefSeq, PubMed]; New data suggest that alpha2-adrenoceptors play no major role on any indices of female sexual behavior. Review article, [RefSeq, PubMed]; Report specific roles of alpha2A - and alpha2B -, but not alpha2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats., [RefSeq, PubMed]; The deleterious effect of prenatal malnutrition on neocortical plasticity in the adult progeny is in part consequence of increased neocortical alpha(2C)-adrenoceptor expression, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0004938 alpha2-adrenergic receptor activity;GO:0031694 alpha-2A adrenergic receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0045666 positive regulation of neuron differentiation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P22086-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25099-1", "uniprot_id": "AA1R_RAT", "mass": 36695.0, "length": 326, "protein_name": "Adenosine receptor A1", "gene_name": "Adora1", "organism": "Rat", "refseq_name": "adenosine receptor A1 isoform 1", "refseq_ac": "NP_058851", "gene_names_uniprotkb": "Adora1", "gene_names_refseq": "Adora1", "protein_names_uniprotkb": "Adenosine receptor A1", "protein_names_refseq": "adenosine receptor A1 isoform 1; adenosine receptor A1", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); left ventricular failure (Disease Ontology:DOID:0051064); hypertension (Disease Ontology:DOID:10763); asthma (Disease Ontology:DOID:2841); cerebral infarction (Disease Ontology:DOID:3526); lung disease (Disease Ontology:DOID:850); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29290); (R-RNO-417973); (R-RNO-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1658635;1857334;33391483;34830353;35653908;37330931;37714421", "class_list": "", "function": "A1 and A2b adenosine receptors regulate GPX4 against ferroptosis of cardiomyocytes in myocardial infarction rat model and in vitro., [RefSeq, PubMed]; Activation of adenosine A1 receptor potentiates metabotropic glutamate receptor 1-mediated Ca[2+] mobilization in the rat hippocampal marginal zone., [RefSeq, PubMed]; Activation of the adenosine A1 receptor in the lumbosacral spinal cord improves bladder overactivity in rats with cystitis induced by cyclophosphamide., [RefSeq, PubMed]; In vivo multimodal imaging of adenosine A1 receptors in neuroinflammation after experimental stroke. Publication Status: Online-Only, [RefSeq, PubMed]; Mediation of the Cardioprotective Effects of Mannitol Discovered, with Refutation of Common Protein Kinases. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for adenosine. The activity of this receptor is mediated by G proteins such as GNAI2 which inhibit adenylyl cyclase (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0001609 G protein-coupled adenosine receptor activity;GO:0001664 G protein-coupled receptor binding;GO:0001883 purine nucleoside binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0042321 negative regulation of circadian sleep/wake cycle, sleep;GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0001659 temperature homeostasis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25114-1", "uniprot_id": "F264_RAT", "mass": 54155.0, "length": 469, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4", "gene_name": "Pfkfb4", "organism": "Rat", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4", "refseq_ac": "NP_062206", "gene_names_uniprotkb": "Pfkfb4", "gene_names_refseq": "Pfkfb4", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ase testis-type isozyme; PFK/FBPase 4", "protein_names_refseq": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4-like; 6PF-2-K/Fru-2,6-P2ASE testis-type isozyme; 6PF-2-K/Fru-2,6-P2ase 4; PFK/FBPase 4", "tax_id": 10116, "disease": "", "pathway": " (rno:54283); (R-RNO-9634600)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1651918;19595670;28235572;8805587;9890980", "class_list": "", "function": "Increased PFKFB4 expression, but not increased PFKFB3 Ser461 phosphorylation, plays a role in increasing glycolysis in mitogen-stimulated thymocytes., [RefSeq, PubMed]; Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, PubMed]; The maximum expression of Pfkfb3 was detected before puberty, while that of Pfkfb4 was observed in adulthood during rat sperm maturation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.46;2.7.1.105", "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006000 fructose metabolic process;GO:0006096 glycolytic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P25114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25305-1", "uniprot_id": "CXB3_RAT", "mass": 30969.0, "length": 270, "protein_name": "Gap junction beta-3 protein", "gene_name": "Gjb3", "organism": "Rat", "refseq_name": "gap junction beta-3 protein", "refseq_ac": "NP_062113", "gene_names_uniprotkb": "Gjb3; Cxn-31", "gene_names_refseq": "Cxnc; Gjb3", "protein_names_uniprotkb": "Gap junction beta-3 protein; Connexin-31; Cx31", "protein_names_refseq": "connexin c; connexin-31; cx31; gap junction beta-3 protein; gap junction membrane channel protein beta 3", "tax_id": 10116, "disease": "erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); autosomal recessive nonsyndromic deafness 1A (Disease Ontology:DOID:0110475); autosomal dominant nonsyndromic deafness 2B (Disease Ontology:DOID:0110559); erythrokeratodermia variabilis et progressiva 1 (Disease Ontology:DOID:0111195); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); cognitive disorder (Disease Ontology:DOID:1561); transient cerebral ischemia (Disease Ontology:DOID:224); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (rno:29585); (R-RNO-190861)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1706719;32157145", "class_list": "", "function": "Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances. Publication Status: Online-Only, [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005911 cell-cell junction;GO:0030054 cell junction;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007267 cell-cell signaling;GO:0007283 spermatogenesis;GO:0071300 cellular response to retinoic acid;GO:0001890 placenta development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P25305-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25409-1", "uniprot_id": "ALAT1_RAT", "mass": 55110.0, "length": 496, "protein_name": "Alanine aminotransferase 1", "gene_name": "Gpt", "organism": "Rat", "refseq_name": "alanine aminotransferase 1", "refseq_ac": "NP_112301", "gene_names_uniprotkb": "Gpt; Aat1; Gpt1", "gene_names_refseq": "ALAT; Gpt1; Gpt", "protein_names_uniprotkb": "Alanine aminotransferase 1; 2.6.1.2; ALT1; GPT 1; Glutamate pyruvate transaminase 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1", "protein_names_refseq": "ALT1; GPT 1; alanine aminotransferase 1; glutamate pyruvate transaminase 1; glutamic pyruvate transaminase; glutamic pyruvic transaminase (alanine aminotrasferase); glutamic pyruvic transaminase 1, soluble; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamic-pyruvate transaminase (alanine aminotransferase)", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obstructive jaundice (Disease Ontology:DOID:13603); acute kidney failure (Disease Ontology:DOID:3021); liver cancer (Disease Ontology:DOID:3571); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); amino acid metabolic disorder (Disease Ontology:DOID:9252); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:81670); (R-RNO-70268); (R-RNO-8964540)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "2043642", "class_list": "", "function": "Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V7F7", "ec_number_list": "2.6.1.2", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0042594 response to starvation;GO:0031667 response to nutrient levels;GO:0042853 L-alanine catabolic process;GO:0045722 positive regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P25409-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26644-1", "uniprot_id": "APOH_RAT", "mass": 33197.0, "length": 297, "protein_name": "Beta-2-glycoprotein 1", "gene_name": "Apoh", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Apoh", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-2-glycoprotein 1; Apo-H; Apolipoprotein H; B2GPI; Beta(2)GPI; Beta-2-glycoprotein I", "protein_names_refseq": "", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); thrombosis (Disease Ontology:DOID:0060903); arteriosclerosis (Disease Ontology:DOID:2349); antiphospholipid syndrome (Disease Ontology:DOID:2988); peripheral vascular disease (Disease Ontology:DOID:341); macular retinal edema (Disease Ontology:DOID:4449); myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:287774); (R-RNO-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21454685;2771654", "class_list": "", "function": "Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:0035473 lipase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0007597 blood coagulation, intrinsic pathway;GO:0010898 positive regulation of triglyceride catabolic process;GO:0051918 negative regulation of fibrinolysis;GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P26644-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27049-1", "uniprot_id": "BTG2_RAT", "mass": 17728.0, "length": 158, "protein_name": "Protein BTG2", "gene_name": "Btg2", "organism": "Rat", "refseq_name": "protein BTG2", "refseq_ac": "NP_058955", "gene_names_uniprotkb": "Btg2; Pc3", "gene_names_refseq": "Agl; An; Btg2; Pc3; Tis21; an-1", "protein_names_uniprotkb": "Protein BTG2; BTG family member 2; NGF-inducible anti-proliferative protein PC3", "protein_names_refseq": "B-cell translocation gene 2, anti-proliferative; BTG family, member 2; Early induced gene B-cell translocation gene 2; NGF-inducible anti-proliferative protein PC3; NGF-inducible anti-proliferative putative secreted protein; cell surface alloantigen; protein BTG2", "tax_id": 10116, "disease": "acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); breast cancer (Disease Ontology:DOID:1612); brain ischemia (Disease Ontology:DOID:2316); renal cell carcinoma (Disease Ontology:DOID:4450); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:29619); (R-RNO-6804115)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11237868;1849653;29393594;32945347;35503009;36759943;37062247;38437946;7811636;8891336", "class_list": "", "function": "Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity)., [UniProtKB]; Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest., [RefSeq, PubMed]; Btg2 mutation induces renal injury and impairs blood pressure control in female rats., [RefSeq, PubMed]; Icariside II protects cardiomyocytes from hypoxiainduced injury by upregulating the miR75p/BTG2 axis and activating the PI3K/Akt signaling pathway., [RefSeq, PubMed]; MicroRNA-322-5p protects against myocardial infarction through targeting BTG2., [RefSeq, PubMed]; The involvement of EGR1 in neuron apoptosis in the in vitro model of spinal cord injury via BTG2 up-regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0008306 associative learning;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P27049-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28233-1", "uniprot_id": "CXA6_RAT", "mass": 32860.0, "length": 286, "protein_name": "Gap junction alpha-6 protein", "gene_name": "Gja6", "organism": "Rat", "refseq_name": "gap junction alpha-6 protein", "refseq_ac": "NP_062181", "gene_names_uniprotkb": "Gja6; Cxn-33", "gene_names_refseq": "Cxnk2; Gja6; cx33; cxn-33", "protein_names_uniprotkb": "Gap junction alpha-6 protein; Connexin-33; Cx33", "protein_names_refseq": "connexin k2; connexin-33; gap junction alpha-6 protein; gap junction membrane channel protein alpha 6", "tax_id": 10116, "disease": "", "pathway": " (rno:54256)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1370487;15331631;16236818", "class_list": "", "function": "Cx33 and Cx43 genes are controlled differently within the testis and suggest that these two Cxs may exert opposite and complementary effects on spermatogenesis., [RefSeq, PubMed]; Data show that in the testis, connexin33 could exert a specific role on germ cell proliferation by suppressing the regulatory effect of connexin43., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007507 heart development;GO:0010644 cell communication by electrical coupling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P28233-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28565-1", "uniprot_id": "5HT1D_RAT", "mass": 41540.0, "length": 374, "protein_name": "5-hydroxytryptamine receptor 1D", "gene_name": "Htr1d", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 1D", "refseq_ac": "NP_036984", "gene_names_uniprotkb": "Htr1d", "gene_names_refseq": "5HT1D; Htr1d", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 1D; 5-HT-1D; 5-HT1D; Serotonin receptor 1D", "protein_names_refseq": "5 - Hydroxytryptamine (serotonin) receptor 1D; 5-HT-1D; 5-HT1D; 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled; 5-hydroxytryptamine receptor 1D; serotonin receptor 1D", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413)", "pathway": " (rno:25323); (R-RNO-390666); (R-RNO-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "19912901;21600121;23155193;23583574;32574671;34061415;8978753", "class_list": "", "function": "5-HTB/D receptors have a role in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:19912901, PubMed:8978753). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (By similarity). Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity (By similarity). May also play a role in regulating the release of other neurotransmitters (By similarity). May play a role in vasoconstriction (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats., [RefSeq, PubMed]; NXN-188 inhibits CGRP release from migraine-relevant cephalic tissues., [RefSeq, PubMed]; The mRNA and protein expressions of 5-HT1D receptor decreased in excessive fatigue rats and restraint stress rats., [RefSeq, PubMed]; The protective effect of alpha7-nACh receptor and its interaction with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion injury in rats., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0001586 Gi/o-coupled serotonin receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0040012 regulation of locomotion;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P28565-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29089-1", "uniprot_id": "AGTRB_RAT", "mass": 40912.0, "length": 359, "protein_name": "Type-1 angiotensin II receptor B", "gene_name": "Agtr1b", "organism": "Rat", "refseq_name": "type-1 angiotensin II receptor B", "refseq_ac": "NP_112271", "gene_names_uniprotkb": "Agtr1b; Agtr1; At1b", "gene_names_refseq": "AT1B; AT1; AT3; AT1R; Agtr1b; Agtr1", "protein_names_uniprotkb": "Type-1 angiotensin II receptor B; AT1 receptor B; AT3; Angiotensin II type-1 receptor B", "protein_names_refseq": "AT1 receptor B; Angiotensin II receptor, type 1 (AT1B); angiotensin II receptor, type-1; angiotensin II type-1 receptor B; angiotensin II type-1 receptor; angiotensin II type-1B receptor; angiotensin receptor 1b; type-1 angiotensin II receptor B; type-1B angiotensin II receptor", "tax_id": 10116, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); COVID-19 (Disease Ontology:DOID:0080600); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); sarcoidosis (Disease Ontology:DOID:11335); Friedreich ataxia (Disease Ontology:DOID:12705); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); IgA glomerulonephritis (Disease Ontology:DOID:2986); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); cerebrovascular disease (Disease Ontology:DOID:6713); chronic kidney disease (Disease Ontology:DOID:784); intermediate coronary syndrome (Disease Ontology:DOID:8805); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (rno:81638)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10191272;1374402;1544458;1567388;1575725;1599457;28161727;37132556;37322348;38606700", "class_list": "", "function": "Analyzing Angiotensin II Receptor Type 1 Clustering in PC12 Cells in Response to Hypoxia Using Direct Stochastic Optical Reconstruction Microscopy (dSTORM)., [RefSeq, PubMed]; Inhibition of angiotensin II type 1 receptor reduces oxidative stress damage to the intestinal barrier in severe acute pancreatitis., [RefSeq, PubMed]; Major components of the renin angiotensin system are located in striatal projection neurons, and striatal astrocytes and microglial cells of rats., [RefSeq, PubMed]; Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C., [UniProtKB, UniProtKB]; The role of T cell stimulated agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) in mediating multiorgan dysfunction in IL-17 induced hypertension during pregnancy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001596 angiotensin type I receptor activity;GO:0004945 angiotensin type II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007584 response to nutrient;GO:0035094 response to nicotine;GO:0045777 positive regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P29089-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29266-1", "uniprot_id": "3HIDH_RAT", "mass": 35303.0, "length": 335, "protein_name": "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "gene_name": "Hibadh", "organism": "Rat", "refseq_name": "3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor", "refseq_ac": "NP_071579", "gene_names_uniprotkb": "Hibadh", "gene_names_refseq": "Hibadh", "protein_names_uniprotkb": "3-hydroxyisobutyrate dehydrogenase, mitochondrial; 1.1.1.31; HIBADH", "protein_names_refseq": "3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor; 3-hydroxyisobutyrate dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:63938); (R-RNO-70895)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18284611;26446791;2647728;27213235;8766712", "class_list": "", "function": "The expression of 3-hydroxyisobutyrate dehydrogenase in neural cells demonstrates their potential to utilize valine imported into the brain for the generation of energy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1L107", "ec_number_list": "1.1.1.31", "go_molecular_function": "GO:0051287 NAD binding;GO:0008442 3-hydroxyisobutyrate dehydrogenase activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006574 L-valine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P29266-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29293-1", "uniprot_id": "ACRO_RAT", "mass": 48623.0, "length": 437, "protein_name": "Acrosin", "gene_name": "Acr", "organism": "Rat", "refseq_name": "acrosin precursor", "refseq_ac": "NP_036622", "gene_names_uniprotkb": "Acr", "gene_names_refseq": "Acro; Acr", "protein_names_uniprotkb": "Acrosin; 3.4.21.10", "protein_names_refseq": "acrosin precursor; acrosin prepropeptide", "tax_id": 10116, "disease": "neuronal ceroid lipofuscinosis 15 (Disease Ontology:DOID:0061189); spermatogenic failure 87 (Disease Ontology:DOID:0070586); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (rno:24163); (R-RNO-1300645)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1802037;1932123;28859281", "class_list": "", "function": "Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome., [UniProtKB]; This study showed that that acrosin disrupted spermatozoa possessed an equal ability to penetrate the zona pellucida with wild-type spermatozoa, but the cumulus cell dispersal was slower compared to wild-type and heterozygous spermatozoa., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4QR89;Q9QWF2", "ec_number_list": "3.4.21.10", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0004040 amidase activity;GO:0005537 D-mannose binding;GO:0042806 fucose binding", "go_cellular_component": "GO:0005798 Golgi-associated vesicle;GO:0001669 acrosomal vesicle;GO:0043159 acrosomal matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006508 proteolysis;GO:0007190 activation of adenylate cyclase activity;GO:0007339 binding of sperm to zona pellucida;GO:0007338 single fertilization;GO:0007340 acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P29293-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29676-1", "uniprot_id": "EPO_RAT", "mass": 21286.0, "length": 192, "protein_name": "Erythropoietin", "gene_name": "Epo", "organism": "Rat", "refseq_name": "erythropoietin precursor", "refseq_ac": "NP_058697", "gene_names_uniprotkb": "Epo", "gene_names_refseq": "Epo", "protein_names_uniprotkb": "Erythropoietin", "protein_names_refseq": "erythropoietin precursor", "tax_id": 10116, "disease": "limb ischemia (Disease Ontology:DOID:0050852); familial erythrocytosis 5 (Disease Ontology:DOID:0080290); Alzheimer's disease (Disease Ontology:DOID:10652); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); neurodegenerative disease (Disease Ontology:DOID:1289); retinopathy of prematurity (Disease Ontology:DOID:13025); porphyria (Disease Ontology:DOID:13268); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); placental insufficiency (Disease Ontology:DOID:3891); macular retinal edema (Disease Ontology:DOID:4449); cholangiocarcinoma (Disease Ontology:DOID:4947); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); vascular dementia (Disease Ontology:DOID:8725); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:24335); (R-RNO-9027276); (R-RNO-9027284)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1420369;34129202;35917324;37578618;38560469;8364201", "class_list": "", "function": "Carbamylated Erythropoietin Alleviates Kidney Damage in Diabetic Rats by Suppressing Oxidative Stress., [RefSeq, PubMed]; Erythropoietin alleviates astrocyte pyroptosis by targeting the miR-325-3p/Gsdmd axis in rat spinal cord injury., [RefSeq, PubMed]; Erythropoietin alleviates lung ischemia-reperfusion injury by activating the FGF23/FGFR4/ERK signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3., [UniProtKB, UniProtKB]; Pulpal expression of erythropoietin and erythropoietin receptor after direct pulp capping in rat., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P70504", "ec_number_list": "", "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0005128 erythropoietin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0044297 cell body", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0043249 erythrocyte maturation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P29676-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29975-1", "uniprot_id": "AQP1_RAT", "mass": 28857.0, "length": 269, "protein_name": "Aquaporin-1", "gene_name": "Aqp1", "organism": "Rat", "refseq_name": "aquaporin-1", "refseq_ac": "NP_036910", "gene_names_uniprotkb": "Aqp1; Chip28", "gene_names_refseq": "Aqp1; CHIP28", "protein_names_uniprotkb": "Aquaporin-1; AQP-1; Aquaporin-CHIP", "protein_names_refseq": "AQP-1; Aquaporin 1 (aquaporin channel forming integral protein 28 (CHIP)); aquaporin 1 (Colton blood group); aquaporin-1; aquaporin-CHIP; water channel protein for red blood cells and kidney proximal tubule", "tax_id": 10116, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); uveitis (Disease Ontology:DOID:13141); retinal vein occlusion (Disease Ontology:DOID:1727); status epilepticus (Disease Ontology:DOID:1824); brain edema (Disease Ontology:DOID:4724); central pontine myelinolysis (Disease Ontology:DOID:636); diabetes mellitus (Disease Ontology:DOID:9351); intracranial hypertension (Disease Ontology:DOID:9428)", "pathway": " (rno:25240); (R-RNO-1237044); (R-RNO-1247673); (R-RNO-432040); (R-RNO-432047)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "1280133;16133142;21454685;22673903;33358303;33506920;36293145;38375595;39238634;7530838;8421053;8457558;8508530", "class_list": "", "function": "A novel interaction between aquaporin 1 and caspase-3 in pulmonary arterial smooth muscle cells., [RefSeq, PubMed]; Altered Expression of AQP1 and AQP4 in Brain Barriers and Cerebrospinal Fluid May Affect Cerebral Water Balance during Chronic Hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Aquaporin 1 is renoprotective in septic acute kidney injury by attenuating inflammation, apoptosis and fibrosis through inhibition of P53 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Differential response of cardiac aquaporins to hyperosmotic stress; salutary role of AQP1 against the induced apoptosis., [RefSeq, PubMed]; Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Testicular AQP1 expression in a rat model of testicular Ischemia-Reperfusion injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5EB50;Q7TN36", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0042802 identical protein binding;GO:0046875 ephrin receptor binding;GO:0005267 potassium channel activity;GO:0005372 water transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016020 membrane", "go_biological_process": "GO:0072237 metanephric proximal tubule development;GO:0019725 cellular homeostasis;GO:0030335 positive regulation of cell migration;GO:0032940 secretion by cell;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P29975-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31430-1", "uniprot_id": "DPEP1_RAT", "mass": 45522.0, "length": 410, "protein_name": "Dipeptidase 1", "gene_name": "Dpep1", "organism": "Rat", "refseq_name": "dipeptidase 1 precursor", "refseq_ac": "NP_446043", "gene_names_uniprotkb": "Dpep1; Rdp", "gene_names_refseq": "Dpep1", "protein_names_uniprotkb": "Dipeptidase 1; 3.4.13.19; 3.5.2.6; Beta-lactamase; Microsomal dipeptidase; Renal dipeptidase", "protein_names_refseq": "beta-lactamase; dipeptidase 1 (renal); dipeptidase 1 precursor; microsomal dipeptidase; renal dipeptidase", "tax_id": 10116, "disease": "hepatoblastoma (Disease Ontology:DOID:687)", "pathway": " (rno:94199); (R-RNO-2142691); (R-RNO-5423646)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "1420313", "class_list": "", "function": "Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Also possesses beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics., [UniProtKB, UniProtKB]; Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6IN35", "ec_number_list": "3.5.2.6;3.1.2.2;3.4.13.19;3.1.-.-", "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0070573 metallodipeptidase activity;GO:0072341 modified amino acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0045177 apical part of cell;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006751 glutathione catabolic process;GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0032869 cellular response to insulin stimulus;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P31430-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32577-1", "uniprot_id": "CSK_RAT", "mass": 50746.0, "length": 450, "protein_name": "Tyrosine-protein kinase CSK", "gene_name": "Csk", "organism": "Rat", "refseq_name": "tyrosine-protein kinase CSK", "refseq_ac": "NP_001025210", "gene_names_uniprotkb": "Csk", "gene_names_refseq": "Csk", "protein_names_uniprotkb": "Tyrosine-protein kinase CSK; 2.7.10.4; C-Src kinase", "protein_names_refseq": "C-SRC kinase; CSK, non-receptor tyrosine kinase; c-src tyrosine kinase; protein-tyrosine kinase (CSK); tyrosine-protein kinase CSK", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:315707); (R-RNO-180292); (R-RNO-202427); (R-RNO-354192); (R-RNO-389948); (R-RNO-5674135); (R-RNO-9013407)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10801129;14613929;1709258;1722201;21873224;23548896;27225249;27391443;7515063", "class_list": "", "function": "An allosteric connection between Cbp binding and Csk activation that arises from residues in the betaB/betaC loop of the SH2 domain., [RefSeq, PubMed]; Ang II increased Csk expression and induced podocyte apoptosis, stimulated Csk translocation and binding to Caveolin-1., [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). May act as a negative regulator of EGFR and STAT3 signaling pathways (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Recruitment of Csk and PTEN to the region between residues 266 and 283 within the C-terminus of Cx43 leads to c-Src inhibition in glioma cells and astrocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G003", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.2;2.7.1.40;3.1.3.48;2.3.1.-;3.6.5.2;2.7.11.13;2.7.11.24;2.7.10.4;3.6.4.6;3.6.4.-;2.7.1.32;2.7.1.82;2.7.11.39;2.7.11.23;3.6.5.-;2.1.1.13", "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway;GO:0006468 protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32577-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35351-1", "uniprot_id": "AGTR2_RAT", "mass": 41331.0, "length": 363, "protein_name": "Type-2 angiotensin II receptor", "gene_name": "Agtr2", "organism": "Rat", "refseq_name": "type-2 angiotensin II receptor", "refseq_ac": "NP_036626", "gene_names_uniprotkb": "Agtr2", "gene_names_refseq": "AT2-R; AT2R; AT2R; Agtr2", "protein_names_uniprotkb": "Type-2 angiotensin II receptor; AT2 receptor; Angiotensin II type-2 receptor", "protein_names_refseq": "AT2 receptor; AT2; angiotensin II type 2 receptor; angiotensin receptor 2; type-2 angiotensin II receptor", "tax_id": 10116, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); stroke (Disease Ontology:DOID:0051061); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); meconium aspiration syndrome (Disease Ontology:DOID:11049); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); renovascular hypertension (Disease Ontology:DOID:1591); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352); vesicoureteral reflux (Disease Ontology:DOID:9620); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:24182); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11068047;35373008;36397318;36922642;38926677;39146457;7490161;7599191;7713098;8227010;8227011", "class_list": "", "function": "Activation of angiotensin II type 2 receptor leads to preservation of primary cilia in tubular cells during renal ischaemia-reperfusion injury., [RefSeq, PubMed]; Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for angiotensin II, a vasoconstricting peptide (PubMed:8227011). Primarily signals via a non-canonical G protein- and beta-arrestin independent pathway. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Relaxin Attenuates Organ Fibrosis via an Angiotensin Type 2 Receptor Mechanism in Aged Hypertensive Female Rats. Publication Status: Online-Only, [RefSeq, PubMed]; The angiotensin II receptors type 1 and 2 modulate astrocytes and their crosstalk with microglia and neurons in an in vitro model of ischemic stroke. Publication Status: Online-Only, [RefSeq, PubMed]; The effect of AT1R-1166A/C and AT2R-1675A/G polymorphisms on susceptibility to preeclampsia: A systematic review and meta-analysis., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001965 G-protein alpha-subunit binding;GO:0004945 angiotensin type II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0060993 kidney morphogenesis;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P35351-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35364-1", "uniprot_id": "5HT5A_RAT", "mass": 40673.0, "length": 357, "protein_name": "5-hydroxytryptamine receptor 5A", "gene_name": "Htr5a", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 5A", "refseq_ac": "NP_037280", "gene_names_uniprotkb": "Htr5a; 5ht5a", "gene_names_refseq": "5HT5A; Htr5a; MR22", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 5A; 5-HT-5A; 5-HT5A; REC17; Serotonin receptor 5A", "protein_names_refseq": "5-HT-5A; 5-HT5A; 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled; 5-hydroxytryptamine receptor 5A; REC17; serotonin receptor 5A", "tax_id": 10116, "disease": "Lennox-Gastaut syndrome (Disease Ontology:DOID:0050561); intracranial hypertension (Disease Ontology:DOID:9428)", "pathway": " (rno:25689); (R-RNO-390666); (R-RNO-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12084412;20863873;26168890;33168874;38408524;7682702", "class_list": "", "function": "5-HT5A receptor-like immunoreactivity has been observed in neuronal somata of the cerebellar cortex and deep cerebellar nuclei., [RefSeq, PubMed]; Even though 5-HT5A receptor gene expression does not change in the hippocampus of any treated group, in rats that are treated with leptin and serotonin, immunostaining specific for 5-HT5A serotonin receptor decreases significantly in the dentate gyrus., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:7682702). Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Htr5a is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity)., [UniProtKB, PubMed, UniProtKB]; Results suggest that 5-HT5A receptors reduce pain processing in the spinal cord, [RefSeq, PubMed]; Role of peripheral 5-HT5A receptors in 5-HT-induced cardiac sympatho-inhibition in type 1 diabetic rats. Publication Status: Online-Only, [RefSeq, PubMed]; The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in the medial prefrontal cortex behave differently in extinction learning: Does social support play a role?, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0001586 Gi/o-coupled serotonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0099634 postsynaptic specialization membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0021766 hippocampus development;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35364-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35365-1", "uniprot_id": "5HT5B_RAT", "mass": 41122.0, "length": 370, "protein_name": "5-hydroxytryptamine receptor 5B", "gene_name": "Htr5b", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 5B", "refseq_ac": "NP_077371", "gene_names_uniprotkb": "Htr5b; 5ht5b", "gene_names_refseq": "5Ht5b; Htr5b; REC17", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 5B; 5-HT-5B; 5-HT5B; MR22; Serotonin receptor 5B", "protein_names_refseq": "5-HT-5B; 5-HT5B; 5-hydroxytryptamine receptor 5B; MR22; serotonin receptor 5B", "tax_id": 10116, "disease": "", "pathway": " (rno:79247)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14618677;7682702;8224165", "class_list": "", "function": "G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:7682702). Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Htr5b is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity)., [UniProtKB, PubMed, UniProtKB]; In the central superior nucleus , the level of coexpression of 5-ht(5B) receptor mRNA with serotonin transporter mRNA was high in the intermediate portions of the nucleus, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0001586 Gi/o-coupled serotonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P35365-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36201-1", "uniprot_id": "CRIP2_RAT", "mass": 22696.0, "length": 208, "protein_name": "Cysteine-rich protein 2", "gene_name": "Crip2", "organism": "Rat", "refseq_name": "cysteine-rich protein 2", "refseq_ac": "NP_071946", "gene_names_uniprotkb": "Crip2; Crip2l2; Crp2", "gene_names_refseq": "CRP2; Crip2", "protein_names_uniprotkb": "Cysteine-rich protein 2; CRP-2; Protein ESP1", "protein_names_refseq": "CRP-2; LIM/double zinc-finger protein; cysteine-rich protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:338401)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10681529;19364329;34502162;8224170", "class_list": "", "function": "Results demonstrated that in undifferentiated olfactory precursor cells Csrp2 was distributed both in the nucleus and the cytoplasm, whereas CRIP2 was predominantly localized in the cytoplasm., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005938 cell cortex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P36201-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36633-1", "uniprot_id": "AOC1_RAT", "mass": 85021.0, "length": 746, "protein_name": "Diamine oxidase [copper-containing]", "gene_name": "Aoc1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Aoc1; Abp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Diamine oxidase [copper-containing]; 1.4.3.22; Amiloride-binding protein 1; Amine oxidase copper domain-containing protein 1; Diamine oxidase; Histaminase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:65029); (R-RNO-211945); (R-RNO-6798695); (R-RNO-70921)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "8023885;8375402", "class_list": "", "function": "Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Its preferred substrates in vitro are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses. Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism. It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q63973", "ec_number_list": "3.6.5.2;2.3.2.5;2.7.1.35;3.4.24.34;3.2.1.17;3.5.3.1;2.3.1.16;2.3.1.9;2.3.1.155;3.4.23.5;1.4.3.22;1.4.3.-;3.1.3.48;3.1.21.-;3.5.1.3;2.7.10.2;3.4.19.9;1.8.3.2;3.2.1.166;3.6.1.6;3.2.1.18;3.4.18.1", "go_molecular_function": "GO:0008201 heparin binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0070062 extracellular exosome;GO:0005576 extracellular region", "go_biological_process": "GO:0009445 putrescine metabolic process;GO:0009308 amine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P36633-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41156-1", "uniprot_id": "ETS1_RAT", "mass": 50423.0, "length": 441, "protein_name": "Protein C-ets-1", "gene_name": "Ets1", "organism": "Rat", "refseq_name": "protein C-ets-1", "refseq_ac": "NP_036687", "gene_names_uniprotkb": "Ets1; Ets-1", "gene_names_refseq": "Ets-1; Ets1; Etsoncb; Tpl1", "protein_names_uniprotkb": "Protein C-ets-1; p54", "protein_names_refseq": "Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1); p54; protein C-ets-1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24356); (R-RNO-2559585)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12048211;22673903;28696249;29856744;31932071;35338235;37672148;8139017", "class_list": "", "function": "Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive rat., [RefSeq, PubMed]; Reduced renal expression of ETS-1 prevented hypertension-associated kidney injury in SS rats, [RefSeq, PubMed]; The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2., [RefSeq, PubMed]; The histone demthylase KDM3A protects the myocardium from ischemia/reperfusion injury via promotion of ETS1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion., [UniProtKB, UniProtKB]; Transcriptomic analysis of neuregulin-1 regulated genes following ischemic stroke by computational identification of promoter binding sites: A role for the ETS-1 transcription factor. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T1H1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0030578 PML body organization;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P41156-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41740-1", "uniprot_id": "ANPRC_RAT", "mass": 59728.0, "length": 535, "protein_name": "Atrial natriuretic peptide receptor 3", "gene_name": "Npr3", "organism": "Rat", "refseq_name": "atrial natriuretic peptide receptor 3 precursor", "refseq_ac": "NP_037000", "gene_names_uniprotkb": "Npr3; Npr-c", "gene_names_refseq": "ANP-CR; NPRC; Npr3", "protein_names_uniprotkb": "Atrial natriuretic peptide receptor 3; ANP-C; ANPR-C; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; NPR-C", "protein_names_refseq": "ANP-C; ANPR-C; ANPRC; Atrial natriuretic peptide clearence receptor 3; NPR-C; atrial natriuretic peptide C-type receptor; atrial natriuretic peptide clearance receptor; atrial natriuretic peptide receptor 3 precursor; atrial natriuretic peptide receptor 3; atrial natriuretic peptide receptor type C; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)", "tax_id": 10116, "disease": "bone disease (Disease Ontology:DOID:0080001); hypertension (Disease Ontology:DOID:10763); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (rno:25339)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "20564198;27494651;29417337;33849828;36243172;37857164;38843836;7554122;7911802", "class_list": "", "function": "Downregulation of natriuretic peptide receptor-C in vascular smooth muscle cells from spontaneously hypertensive rats contributes to vascular remodeling., [RefSeq, PubMed]; LncRNA NONRATT014888.2 contributes to cancer-induced bone pain through downregulation of natriuretic peptide receptor 3 in rats., [RefSeq, PubMed]; NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-alpha, which are regulators of apoptosis., [RefSeq, PubMed]; Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results indicate that C-ANP4-23, via the activation of NPR-C, attenuates Ang II-induced enhanced nitroxidative stress, overexpression of Gialpha proteins, increased activation of the p38/JNK/ERK 1,2 signaling pathways., [RefSeq, PubMed]; [Changes of guanylate cyclase C in colon tissues of rats with intestinal injury associated with severe acute pancreatitis]., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q64156", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031404 chloride ion binding;GO:0042562 hormone binding;GO:0017046 peptide hormone binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032991 protein-containing complex;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0002931 response to ischemia;GO:0007165 signal transduction;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007194 negative regulation of adenylate cyclase activity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P41740-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43140-1", "uniprot_id": "ADA1A_RAT", "mass": 51598.0, "length": 466, "protein_name": "Alpha-1A adrenergic receptor", "gene_name": "Adra1a", "organism": "Rat", "refseq_name": "alpha-1A adrenergic receptor", "refseq_ac": "NP_058887", "gene_names_uniprotkb": "Adra1a; Adra1c", "gene_names_refseq": "Adra1a; Adra1c", "protein_names_uniprotkb": "Alpha-1A adrenergic receptor; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor", "protein_names_refseq": "adrenergic alpha 1c receptor; adrenergic receptor alpha 1c subtype; adrenergic receptor, alpha 1a; adrenergic receptor, alpha 1c; adrenergic, alpha-1A-, receptor; alpha-1A adrenergic receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic receptor", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); polycystic ovary syndrome (Disease Ontology:DOID:11612); bladder neck obstruction (Disease Ontology:DOID:13948); alcohol use disorder (Disease Ontology:DOID:1574); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29412); (R-RNO-390696); (R-RNO-416476); (R-RNO-416482)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "33025031;33166680;34062902;34204888;7923624;7935320;8185565", "class_list": "", "function": "Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1A binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) protein. Nuclear ADRA1A forms heterooligomers with ADRA1B to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. At the plasma membrane, ADRA1A interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy. Additionally, functions as a vasopressor in resistance arteries and plays a role in maintaining normal arterial blood pressure., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Antidepressants Differentially Regulate Intracellular Signaling from alpha1-Adrenergic Receptor Subtypes In Vitro. Publication Status: Online-Only, [RefSeq, PubMed]; Centruroides margaritatus scorpion complete venom exerts cardiovascular effects through alpha-1 adrenergic receptors., [RefSeq, PubMed]; MAPKs Are Highly Abundant but Do Not Contribute to alpha1-Adrenergic Contraction of Rat Saphenous Arteries in the Early Postnatal Period. Publication Status: Online-Only, [RefSeq, PubMed]; Negative relationship between brain alpha1A-AR neurotransmission and betaArr2 levels in anxious adolescent rats subjected to early life stress., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004937 alpha1-adrenergic receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0043410 positive regulation of MAPK cascade;GO:0045987 positive regulation of smooth muscle contraction;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P43140-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43301-1", "uniprot_id": "EGR3_RAT", "mass": 42606.0, "length": 387, "protein_name": "Early growth response protein 3", "gene_name": "Egr3", "organism": "Rat", "refseq_name": "early growth response protein 3", "refseq_ac": "NP_058782", "gene_names_uniprotkb": "Egr3; Egr-3", "gene_names_refseq": "EGR-3; Egr3", "protein_names_uniprotkb": "Early growth response protein 3; EGR-3", "protein_names_refseq": "early growth response protein 3", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); COVID-19 (Disease Ontology:DOID:0080600); Raynaud disease (Disease Ontology:DOID:10300); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); intracranial aneurysm (Disease Ontology:DOID:10941); sarcoidosis (Disease Ontology:DOID:11335); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); Down syndrome (Disease Ontology:DOID:14250); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); carotid artery disease (Disease Ontology:DOID:3407); neuropathy (Disease Ontology:DOID:870); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:25148)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10467592;16091474;25817788;26775236;31858986;33723811;36098762", "class_list": "", "function": "EGR3 regulates opioid-related nociception and motivation in male rats., [RefSeq, PubMed]; Egr3 as a major regulator of gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4 in developing neurons and in epilepsy Erratum:[Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13351. Passini, MJ [corrected to Passini, MA]], [RefSeq, PubMed]; Overexpression of EGR3 gene in an animal model of audiogenic seizures contributes to neuronal viability., [RefSeq, PubMed]; Probable transcription factor involved in muscle spindle development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Regional brain network and behavioral alterations in EGR3 gene transfected rat model of schizophrenia., [RefSeq, PubMed]; Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny Neurons Following Long-Term Abstinence From Cocaine Self-administration., [RefSeq, PubMed]; Successfully created a rat model of schizophrenia by the transfection of EGR3 gene into rat brain. We then investigated the connectivity density of schizophrenia susceptible regions in rat brain using functional magnetic resonance imaging, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0045202 synapse", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007274 neuromuscular synaptic transmission;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P43301-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43428-1", "uniprot_id": "G6PC1_RAT", "mass": 40556.0, "length": 357, "protein_name": "Glucose-6-phosphatase catalytic subunit 1", "gene_name": "G6pc1; Psme3", "organism": "Rat", "refseq_name": "glucose-6-phosphatase catalytic subunit 1", "refseq_ac": "NP_037230", "gene_names_uniprotkb": "G6pc1; Psme3; G6pc; G6pt; Psme3", "gene_names_refseq": "G6Pase; G6pc1; G6pc; Psme3", "protein_names_uniprotkb": "Glucose-6-phosphatase catalytic subunit 1; 3.1.3.9; G-6-Pase; G6Pase; Glucose-6-phosphatase", "protein_names_refseq": "G-6-Pase; glucose-6-phosphatase catalytic subunit 1; glucose-6-phosphatase, catalytic subunit; proteasome activator subunit 3", "tax_id": 10116, "disease": "glycogen storage disease Ia (Disease Ontology:DOID:2749); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:25634); (R-RNO-70263)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "7860767;8198588;8865366", "class_list": "", "function": "Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVC9", "ec_number_list": "3.1.3.9;3.1.3.94;3.1.3.25", "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0016773 phosphotransferase activity, alcohol group as acceptor;GO:0004346 glucose-6-phosphatase activity;GO:0042802 identical protein binding;GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005654 nucleoplasm;GO:0000502 proteasome complex", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0032869 cellular response to insulin stimulus;GO:0055088 lipid homeostasis;GO:0005977 glycogen metabolic process;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P43428-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46844-1", "uniprot_id": "BIEA_RAT", "mass": 33566.0, "length": 295, "protein_name": "Biliverdin reductase A", "gene_name": "Blvra", "organism": "Rat", "refseq_name": "biliverdin reductase A", "refseq_ac": "NP_446302", "gene_names_uniprotkb": "Blvra; Blvr", "gene_names_refseq": "Blvra", "protein_names_uniprotkb": "Biliverdin reductase A; 1.3.1.24; BVR A; Biliverdin-IX alpha-reductase", "protein_names_refseq": "BVR A; biliverdin reductase A; biliverdin-IX alpha-reductase", "tax_id": 10116, "disease": "", "pathway": " (rno:116599); (R-RNO-189483); (R-RNO-9707564)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10957639;12079357;1371282;17402939;20876213;22673903;23722043;8020496", "class_list": "", "function": "BVR contributes to the inhibitory process of hypoxia on pulmonary arterial smooth muscle cell apoptosis, which is mediated by bilirubin through ERK1/2 pathway., [RefSeq, PubMed]; Data show that siRNA blockage of BVR protein expression in cardiomyocytes inhibits HO-2 protein induction but not vice versa., [RefSeq, PubMed]; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:1371282, PubMed:8020496). Does not reduce bilirubin IXbeta (By similarity). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:1371282, PubMed:8020496). NADPH, however, is the probable reactant in biological systems (PubMed:8020496)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results describe the activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions., [RefSeq, PubMed]; X-ray crystal structures of apo rat BVR and its complex with NADH at 1.2 A and 1.5 A resolution, respectively, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.1.24", "go_molecular_function": "GO:0106276 biliberdin reductase (NADH) activity;GO:0106277 biliverdin reductase (NADPH) activity;GO:0004674 protein serine/threonine kinase activity;GO:0008270 zinc ion binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0009986 cell surface", "go_biological_process": "GO:0061010 gallbladder development;GO:1901142 insulin metabolic process;GO:1903409 reactive oxygen species biosynthetic process;GO:0034440 lipid oxidation;GO:0038178 complement component C5a signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P46844-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47197-1", "uniprot_id": "AKT2_RAT", "mass": 55543.0, "length": 481, "protein_name": "RAC-beta serine/threonine-protein kinase", "gene_name": "Akt2", "organism": "Rat", "refseq_name": "RAC-beta serine/threonine-protein kinase isoform 1", "refseq_ac": "NP_058789", "gene_names_uniprotkb": "Akt2", "gene_names_refseq": "Akt2", "protein_names_uniprotkb": "RAC-beta serine/threonine-protein kinase; 2.7.11.1; PKB beta; Protein kinase Akt-2; Protein kinase B beta; RAC-PK-beta", "protein_names_refseq": "AKT2 kinase; PKB beta; RAC protein kinase beta RAC-PK beta; RAC-PK-beta; RAC-beta serine/threonine-protein kinase isoform 1; RAC-beta serine/threonine-protein kinase; murine thymoma viral (v-akt) oncogene homolog 2; protein kinase Akt-2; protein kinase B beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2", "tax_id": 10116, "disease": "hypoinsulinemic hypoglycemia with hemihypertrophy (Disease Ontology:DOID:0112263); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); polycystic ovary syndrome (Disease Ontology:DOID:11612); cholestasis (Disease Ontology:DOID:13580); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); prostate adenocarcinoma (Disease Ontology:DOID:2526); carcinoma (Disease Ontology:DOID:305); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); bipolar disorder (Disease Ontology:DOID:3312); ovarian carcinoma (Disease Ontology:DOID:4001); sleep disorder (Disease Ontology:DOID:535); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:25233); (R-RNO-1257604); (R-RNO-1358803); (R-RNO-165158); (R-RNO-165159); (R-RNO-165181); (R-RNO-198323); (R-RNO-198693); (R-RNO-199418); (R-RNO-211163); (R-RNO-3769402); (R-RNO-389357); (R-RNO-389513); (R-RNO-392451); (R-RNO-5218920); (R-RNO-5628897); (R-RNO-6804757); (R-RNO-6804758); (R-RNO-6804759); (R-RNO-69202); (R-RNO-69656); (R-RNO-8876198); (R-RNO-8948751); (R-RNO-9607240); (R-RNO-9614399); (R-RNO-9634638); (R-RNO-9755511)", "pathway_count": 27, "publication_count": 13, "publication_id_list": "11781143;16000877;21432781;21620960;22673903;26739650;27966646;28365702;30444896;36427136;37184210;7999118;9512493", "class_list": "", "function": "Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity., [RefSeq, PubMed]; Data identify previously unrecognized Akt2 kinase as a driver of TGFbeta induced deptor downregulation and sustained mTORC1 and mTORC2 activation. Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA-137 inhibits pituitary prolactinoma proliferation by targeting AKT2., [RefSeq, PubMed]; Serine/threonine kinase closely related to AKT1 and AKT3. All 3 enzymes, AKT1, AKT2 and AKT3, are collectively known as AKT kinase. AKT regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis, through the phosphorylation of a range of downstream substrates. Over 100 substrates have been reported so far, although for most of them, the precise AKT kinase catalyzing the reaction was not specified. AKT regulates glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1). AKT mediates the antiapoptotic effects of IGF1. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development (PubMed:21432781, PubMed:21620960). In response to lysophosphatidic acid stimulation, inhibits the ciliogenesis cascade. In this context, phosphorylates WDR44, hence stabilizing its interaction with Rab11 and preventing the formation of the ciliogenic Rab11-FIP3-RAB3IP complex. Also phosphorylates RAB3IP/Rabin8, thus may affect RAB3IP guanine nucleotide exchange factor (GEF) activity toward Rab8, which is important for cilia growth (By similarity). Phosphorylates PKP1, facilitating its interaction with YWHAG and translocation to the nucleus, ultimately resulting in a reduction in keratinocyte intercellular adhesion (By similarity). Phosphorylation of PKP1 increases PKP1 protein stability, translocation to the cytoplasm away from desmosome plaques and PKP1-driven cap-dependent translation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Several AKT2-specific substrates have been identified, including ANKRD2, C2CD5, CLK2 and PITX2. May play a role in myoblast differentiation. In this context, may act through PITX2 phosphorylation. Unphosphorylated PITX2 associates with an ELAVL1/HuR-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation (By similarity). Also involved in the negative regulation of myogenesis in response to stress conditions. In this context, acts by phosphorylating ANKRD2 (By similarity). May also be a key regulator of glucose uptake. Regulates insulin-stimulated glucose transport by the increase of glucose transporter GLUT4 translocation from intracellular stores to the plasma membrane. In this context, acts by phosphorylating C2CD5/CDP138 on 'Ser-197' in insulin-stimulated adipocytes (By similarity). Through the phosphorylation of CLK2 on 'Thr-343', involved in insulin-regulated suppression of hepatic gluconeogenesis (By similarity)., [UniProtKB, UniProtKB]; The results of this study suggest that phosphorylation of Akt2 mediates the beneficial effects of galanin on insulin-induced glucose uptake in the adipocytes of diabetic rats., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 25, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.3.2.27;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;3.4.19.12;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.10;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.1.2.2;3.6.5.-;2.7.11.39;2.4.99.18;3.4.22.62", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:1904179 positive regulation of adipose tissue development;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P47197-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48199-1", "uniprot_id": "CRP_RAT", "mass": 25468.0, "length": 230, "protein_name": "C-reactive protein", "gene_name": "Crp", "organism": "Rat", "refseq_name": "C-reactive protein precursor", "refseq_ac": "NP_058792", "gene_names_uniprotkb": "Crp; Ptx1", "gene_names_refseq": "Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262; Ac2-069; Ba2-693; Crp", "protein_names_uniprotkb": "C-reactive protein", "protein_names_refseq": "C-reactive protein precursor; C-reactive protein, member of the pentraxin family; C-reactive protein, pentraxin-related; C-reactive protein, petaxin related", "tax_id": 10116, "disease": "mevalonic aciduria (Disease Ontology:DOID:0050452); inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); atrial fibrillation (Disease Ontology:DOID:0060224); mastoiditis (Disease Ontology:DOID:0060322); overactive bladder syndrome (Disease Ontology:DOID:0070355); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); lupus nephritis (Disease Ontology:DOID:0080162); COVID-19 (Disease Ontology:DOID:0080600); cataract 4 multiple types (Disease Ontology:DOID:0110234); cataract 2 multiple types (Disease Ontology:DOID:0110235); cataract 7 (Disease Ontology:DOID:0110260); pelvic inflammatory disease (Disease Ontology:DOID:1003); bacterial infectious disease (Disease Ontology:DOID:104); interstitial nephritis (Disease Ontology:DOID:1063); renal hypertension (Disease Ontology:DOID:1073); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); heart disease (Disease Ontology:DOID:114); pyelonephritis (Disease Ontology:DOID:11400); hypertensive retinopathy (Disease Ontology:DOID:11561); familial hyperlipidemia (Disease Ontology:DOID:1168); iron deficiency anemia (Disease Ontology:DOID:11758); vestibular neuronitis (Disease Ontology:DOID:12683); cardiovascular system disease (Disease Ontology:DOID:1287); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); low tension glaucoma (Disease Ontology:DOID:13544); aspergillosis (Disease Ontology:DOID:13564); pharyngoconjunctival fever (Disease Ontology:DOID:13801); interstitial cystitis (Disease Ontology:DOID:13949); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); urticaria (Disease Ontology:DOID:1555); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); anxiety disorder (Disease Ontology:DOID:2030); colon cancer (Disease Ontology:DOID:219); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); pulmonary tuberculosis (Disease Ontology:DOID:2957); antiphospholipid syndrome (Disease Ontology:DOID:2988); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); mouth disease (Disease Ontology:DOID:403); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); uveal melanoma (Disease Ontology:DOID:6039); acute stress disorder (Disease Ontology:DOID:6088); lymphopenia (Disease Ontology:DOID:614); pulmonary hypertension (Disease Ontology:DOID:6432); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); cataract (Disease Ontology:DOID:83); arthritis (Disease Ontology:DOID:848); polymyalgia rheumatica (Disease Ontology:DOID:853); Crohn's disease (Disease Ontology:DOID:8778); intermediate coronary syndrome (Disease Ontology:DOID:8805); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); otitis externa (Disease Ontology:DOID:9463); bacterial meningitis (Disease Ontology:DOID:9470); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25419); (R-RNO-173623)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1737750;21679689;33385735;33544171;35503088;36765308;37515488;8486673", "class_list": "", "function": "C-reactive protein inhibits C3a/C3aR-dependent podocyte autophagy in favor of diabetic kidney disease. Erratum:[FASEB J. 2022 Dec;36(12):e22640. doi: 10.1096/fsb2.22640. PMID: 36315181], [RefSeq, PubMed]; Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Genetic ablation of C-reactive protein gene confers resistance to obesity and insulin resistance in rats., [RefSeq, PubMed]; Temporal and spatial effects on C-reactive protein's regulation of inducible nitric oxide synthase production in periodontal disease., [RefSeq, PubMed]; The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA. Publication Status: Online-Only, [RefSeq, PubMed]; What is the role of CRP in glioblastoma?, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 89, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5BK94", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0005509 calcium ion binding;GO:0015485 cholesterol binding;GO:0030169 low-density lipoprotein particle binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030426 growth cone;GO:0030175 filopodium;GO:0005576 extracellular region", "go_biological_process": "GO:0010888 negative regulation of lipid storage;GO:0010288 response to lead ion;GO:0010628 positive regulation of gene expression;GO:0032930 positive regulation of superoxide anion generation;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P48199-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48317-1", "uniprot_id": "GA45A_RAT", "mass": 18480.0, "length": 165, "protein_name": "Growth arrest and DNA damage-inducible protein GADD45 alpha", "gene_name": "Gadd45a", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gadd45a; Ddit1; Gadd45", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth arrest and DNA damage-inducible protein GADD45 alpha; DDIT-1; DNA damage-inducible transcript 1 protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); peripheral artery disease (Disease Ontology:DOID:0050830); atrial heart septal defect 1 (Disease Ontology:DOID:0110106); intracranial aneurysm (Disease Ontology:DOID:10941); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); capillary hemangioma (Disease Ontology:DOID:2725); high grade glioma (Disease Ontology:DOID:3070); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (R-RNO-6804114)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7828885;8603754", "class_list": "", "function": "Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0019900 kinase binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48317-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48750-1", "uniprot_id": "CSF2_RAT", "mass": 16562.0, "length": 144, "protein_name": "Granulocyte-macrophage colony-stimulating factor", "gene_name": "Csf2", "organism": "Rat", "refseq_name": "granulocyte-macrophage colony-stimulating factor precursor", "refseq_ac": "NP_446304", "gene_names_uniprotkb": "Csf2; Csfgm", "gene_names_refseq": "Csf2; Gm-csf; Gmcsf", "protein_names_uniprotkb": "Granulocyte-macrophage colony-stimulating factor; CSF; Colony-stimulating factor; GM-CSF", "protein_names_refseq": "CSF; colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor precursor; granulocyte-macrophage colony-stimulating factor", "tax_id": 10116, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); COVID-19 (Disease Ontology:DOID:0080600); Parkinsonism (Disease Ontology:DOID:0080855); silicosis (Disease Ontology:DOID:10325); pneumocystosis (Disease Ontology:DOID:11339); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); neutropenia (Disease Ontology:DOID:1227); temporal arteritis (Disease Ontology:DOID:13375); interstitial cystitis (Disease Ontology:DOID:13949); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); myocardial infarction (Disease Ontology:DOID:5844); abdominal aortic aneurysm (Disease Ontology:DOID:7693); acute myeloid leukemia (Disease Ontology:DOID:9119); visceral leishmaniasis (Disease Ontology:DOID:9146)", "pathway": " (rno:116630); (R-RNO-512988); (R-RNO-5673001); (R-RNO-912526)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "25677907;27364613;28550897;28898718;8225444", "class_list": "", "function": "Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes., [UniProtKB]; Findings demonstrate that IL-17 regulates SHP-2 expression and IL-17RA/STAT-3 dependent production of Cyr61, IL-23, GM-CSF and RANKL in AA-FLS and may reveal a new insight into the pathogenesis of RA., [RefSeq, PubMed]; Mesenteric mesothelial cells express GM-CSF receptor on the plasma membrane; during inflammation they synthesize and secrete GM-CSF that can stimulate GM-CSF receptor expression and mesothelial cell to macrophage-like cell transformation; in this transformation, GM-CSF (together with its receptor and other cytokines) has a major autocrine regulatory role; receptor-ligand internalization is essential for GM-CSF signalling, [RefSeq, PubMed]; The findings that ephrinA1-PE38/GM-CSF had a high efficacy in the activation of the dendritic cells would facilitate the development of in vivo dendritic-cell vaccines for the treatment of gliomas in rats, [RefSeq, PubMed]; Transplant vasculopathy depends on the simultaneous and complementary additive effects of granulocyte-macrophage colony-stimulating factor and cytokines, which have a continuous 'cross talk.', [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005129 granulocyte macrophage colony-stimulating factor receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex;GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:1904075 positive regulation of trophectodermal cell proliferation;GO:0030223 neutrophil differentiation;GO:0032747 positive regulation of interleukin-23 production;GO:0034021 response to silicon dioxide;GO:0042045 epithelial fluid transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P48750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48973-1", "uniprot_id": "CXL10_RAT", "mass": 10729.0, "length": 98, "protein_name": "C-X-C motif chemokine 10", "gene_name": "Cxcl10", "organism": "Rat", "refseq_name": "C-X-C motif chemokine 10 precursor", "refseq_ac": "NP_620789", "gene_names_uniprotkb": "Cxcl10; Inp10; Mob1; Scyb10", "gene_names_refseq": "Cxcl10; IP-10; Scyb10", "protein_names_uniprotkb": "C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Interferon-inducible protein 10; Protein Mob-1; Small-inducible cytokine B10", "protein_names_refseq": "10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10 precursor; C-X-C motif chemokine 10; chemokine (C-X-C motif) ligand 10; gamma-IP10; interferon-inducible cytokine IP-10; interferon-inducible protein 10; protein Mob-1; small inducible cytokine B subfamily (Cys-X-Cys) member 10; small inducible cytokine B subfamily (Cys-X-Cys), member 10; small-inducible cytokine B10", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); common cold (Disease Ontology:DOID:10459); adult respiratory distress syndrome (Disease Ontology:DOID:11394); uveitis (Disease Ontology:DOID:13141); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cholestasis (Disease Ontology:DOID:13580); interstitial cystitis (Disease Ontology:DOID:13949); thoracic aortic aneurysm (Disease Ontology:DOID:14004); renovascular hypertension (Disease Ontology:DOID:1591); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); brain ischemia (Disease Ontology:DOID:2316); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic scleroderma (Disease Ontology:DOID:418); coronary restenosis (Disease Ontology:DOID:4247); myasthenia gravis (Disease Ontology:DOID:437); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); proteinuria (Disease Ontology:DOID:576); hepatocellular carcinoma (Disease Ontology:DOID:684); myocarditis (Disease Ontology:DOID:820); extrinsic allergic alveolitis (Disease Ontology:DOID:841); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); encephalitis (Disease Ontology:DOID:9588); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:245920); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "30257241;30448292;35542987;35548957;37146769;37475184;7809069;8798675", "class_list": "", "function": "CXCL10 is a novel anti-angiogenic factor downstream of p53 in cardiomyocytes., [RefSeq, PubMed]; Photobiomodulation reduces neuropathic pain after spinal cord injury by downregulating CXCL10 expression., [RefSeq, PubMed]; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity) (PubMed:30257241, PubMed:30448292)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10 axis in rats with depressive-like behaviors., [RefSeq, PubMed]; Ursolic acid inhibits Th17 cell differentiation via STAT3/RORgammat pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70538;Q6GTC7", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0005125 cytokine activity;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P48973-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50554-1", "uniprot_id": "GABT_RAT", "mass": 56456.0, "length": 500, "protein_name": "4-aminobutyrate aminotransferase, mitochondrial", "gene_name": "Abat", "organism": "Rat", "refseq_name": "4-aminobutyrate aminotransferase, mitochondrial", "refseq_ac": "NP_112265", "gene_names_uniprotkb": "Abat; Gabat", "gene_names_refseq": "Abat; Gabat; beta-AlaAT", "protein_names_uniprotkb": "4-aminobutyrate aminotransferase, mitochondrial; (S)-3-amino-2-methylpropionate transaminase; 2.6.1.19; 2.6.1.22; GABA aminotransferase; GABA transaminase; GABA-AT; GABA-T; Gamma-amino-N-butyrate transaminase; L-AIBAT; beta-AlaAT I", "protein_names_refseq": "(S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate aminotransferase, mitochondrial; GABA aminotransferase; GABA transaminase; GABA-AT; GABA-T; L-AIBAT; beta-AlaAT I; gamma-amino-N-butyrate transaminase", "tax_id": 10116, "disease": "West syndrome (Disease Ontology:DOID:0050562); GABA aminotransferase deficiency (Disease Ontology:DOID:0060174); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); reflex epilepsy (Disease Ontology:DOID:2548); ischemia (Disease Ontology:DOID:326); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:81632); (R-RNO-916853)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10447691;10989446;24809054;31534049;8133261", "class_list": "", "function": "Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10447691). Can also convert delta-aminovalerate and beta-alanine (PubMed:10447691)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Daytime restricted feeding influences the daily variations of GABA-T mRNA levels, stability, and catalytic activity of GABA-T., [RefSeq, PubMed]; Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70539;Q66HM1", "ec_number_list": "2.6.1.19;2.6.1.22", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0032144 4-aminobutyrate transaminase complex", "go_biological_process": "GO:0007626 locomotory behavior;GO:0032024 positive regulation of insulin secretion;GO:0035094 response to nicotine;GO:0045471 response to ethanol;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51538-1", "uniprot_id": "CP3A9_RAT", "mass": 57812.0, "length": 503, "protein_name": "Cytochrome P450 3A9", "gene_name": "Cyp3a9", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cyp3a9; Cyp3a13", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 3A9; 1.14.14.1; 3AH15; CYPIIIA9; Cytochrome P450 olfactive 3; Cytochrome P450-OLF3", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); essential hypertension (Disease Ontology:DOID:10825); familial Mediterranean fever (Disease Ontology:DOID:2987); liver cirrhosis (Disease Ontology:DOID:5082); oral submucous fibrosis (Disease Ontology:DOID:5773); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:171352); (R-RNO-211945); (R-RNO-211958); (R-RNO-211981); (R-RNO-5423646); (R-RNO-9027307); (R-RNO-9749641); (R-RNO-9754706); (R-RNO-9757110)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "29393594;8660328;8990268", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB, UniProtKB]; This isozyme seems to be implicated in olfaction. Active in the demethylation of erythromycin as well as benzphetamine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64557;Q64631", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002933 lipid hydroxylation;GO:0008210 estrogen metabolic process;GO:0010043 response to zinc ion;GO:0010628 positive regulation of gene expression;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51538-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52020-1", "uniprot_id": "ERG1_RAT", "mass": 64024.0, "length": 573, "protein_name": "Squalene monooxygenase", "gene_name": "Sqle", "organism": "Rat", "refseq_name": "squalene monooxygenase", "refseq_ac": "NP_058832", "gene_names_uniprotkb": "Sqle; Erg1", "gene_names_refseq": "Sqle", "protein_names_uniprotkb": "Squalene monooxygenase; 1.14.14.17; SE; Squalene epoxidase", "protein_names_refseq": "SE; squalene monooxygenase", "tax_id": 10116, "disease": "atelosteogenesis (Disease Ontology:DOID:0050648); Boomerang dysplasia (Disease Ontology:DOID:0050680); spinal disease (Disease Ontology:DOID:0060564); bone development disease (Disease Ontology:DOID:0080006); myofibrillar myopathy 5 (Disease Ontology:DOID:0080096); spondylocarpotarsal synostosis syndrome (Disease Ontology:DOID:0090116); distal myopathy 4 (Disease Ontology:DOID:0111190); clubfoot (Disease Ontology:DOID:11836); Larsen syndrome (Disease Ontology:DOID:14764); cancer (Disease Ontology:DOID:162); osteochondrodysplasia (Disease Ontology:DOID:2256); myopathy (Disease Ontology:DOID:423); cleft palate (Disease Ontology:DOID:674)", "pathway": " (rno:29230); (R-RNO-9969896)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12083769;17112472;29393594;7814369", "class_list": "", "function": "Aromatic residues are likely to be located at the substrate-binding domain of the active-site, and control the stereochemical course of the squalene epoxidase reaction, [RefSeq, PubMed]; Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Functional promotor regions involved in transcription was determined, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8L3", "ec_number_list": "1.14.14.17", "go_molecular_function": "GO:0071949 FAD binding;GO:0004506 squalene monooxygenase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0042127 regulation of cell population proliferation;GO:0016126 sterol biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P52020-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52796-1", "uniprot_id": "EFNB1_RAT", "mass": 37951.0, "length": 345, "protein_name": "Ephrin-B1", "gene_name": "Efnb1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Efnb1; Eplg2; Lerk2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin-B1; EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); craniofrontonasal syndrome (Disease Ontology:DOID:14737); dysostosis (Disease Ontology:DOID:1934)", "pathway": " (rno:25186); (R-RNO-2682334); (R-RNO-3928662); (R-RNO-3928664); (R-RNO-3928665)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "10197531;7936648", "class_list": "", "function": "Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7936648). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (By similarity). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7936648). Can also bind EPHB2 and EPHB3 (By similarity). Binds to, and induces the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0099054 presynapse assembly;GO:0007399 nervous system development;GO:0048013 ephrin receptor signaling pathway;GO:0031295 T cell costimulation;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P52796-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53676-1", "uniprot_id": "AP3M1_RAT", "mass": 46981.0, "length": 418, "protein_name": "AP-3 complex subunit mu-1", "gene_name": "Ap3m1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ap3m1", "gene_names_refseq": "", "protein_names_uniprotkb": "AP-3 complex subunit mu-1; AP-3 adaptor complex mu3A subunit; Adaptor-related protein complex 3 subunit mu-1; Clathrin assembly protein assembly protein complex 3 mu-1 medium chain; Clathrin coat assembly protein AP47 homolog 1; Clathrin coat-associated protein AP47 homolog 1; Golgi adaptor AP-1 47 kDa protein homolog 1; HA1 47 kDa subunit homolog 1; Mu-adaptin 3A; Mu3A-adaptin; P47A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8076832", "class_list": "", "function": "Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0098837 postsynaptic recycling endosome;GO:0005802 trans-Golgi network;GO:1904115 axon cytoplasm;GO:0030121 AP-1 adaptor complex;GO:0012505 endomembrane system", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0008089 anterograde axonal transport;GO:0048490 anterograde synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P53676-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53678-1", "uniprot_id": "AP3M2_RAT", "mass": 46874.0, "length": 418, "protein_name": "AP-3 complex subunit mu-2", "gene_name": "Ap3m2", "organism": "Rat", "refseq_name": "AP-3 complex subunit mu-2", "refseq_ac": "NP_579839", "gene_names_uniprotkb": "Ap3m2", "gene_names_refseq": "Ap3m2", "protein_names_uniprotkb": "AP-3 complex subunit mu-2; Adaptor-related protein complex 3 subunit mu-2; Clathrin assembly protein assembly protein complex 3 mu-2 medium chain; Clathrin coat assembly protein AP47 homolog 2; Clathrin coat-associated protein AP47 homolog 2; Golgi adaptor AP-1 47 kDa protein homolog 2; HA1 47 kDa subunit homolog 2; Mu3B-adaptin; P47B", "protein_names_refseq": "AP-3 complex subunit mu-2; HA1 47 kDa subunit homolog 2; P47B; adapter-related protein complex 3 mu-2 subunit; adapter-related protein complex 3 subunit mu-2; adaptor-related protein complex 3, mu 2 subunit; clathrin assembly protein assembly protein complex 1 medium chain homolog 2; clathrin assembly protein assembly protein complex 3 mu-2 medium chain; clathrin coat assembly protein AP47 homolog 2; clathrin coat-associated protein AP47 homolog 2; golgi adaptor AP-1 47 kDa protein homolog 2; mu3B-adaptin", "tax_id": 10116, "disease": "", "pathway": " (rno:140667)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8076832", "class_list": "", "function": "Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Ap47 is a subunit of the plasma membrane adaptor. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005802 trans-Golgi network;GO:1904115 axon cytoplasm;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0008089 anterograde axonal transport;GO:0048490 anterograde synaptic vesicle transport;GO:0007269 neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P53678-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55051-1", "uniprot_id": "FABP7_RAT", "mass": 14864.0, "length": 132, "protein_name": "Fatty acid-binding protein, brain", "gene_name": "Fabp7", "organism": "Rat", "refseq_name": "fatty acid-binding protein, brain", "refseq_ac": "NP_110459", "gene_names_uniprotkb": "Fabp7; Blbp", "gene_names_refseq": "Fabp7", "protein_names_uniprotkb": "Fatty acid-binding protein, brain; B-FABP; BLBP; Brain lipid-binding protein; Brain-type fatty acid-binding protein; Fatty acid-binding protein 7", "protein_names_refseq": "B-FABP; BLBP; brain lipid-binding protein; brain-type fatty acid-binding protein; fatty acid binding protein 7, brain; fatty acid-binding protein, brain", "tax_id": 10116, "disease": "glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (rno:80841); (R-RNO-163560)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16237179;23996503;29048614;7931318", "class_list": "", "function": "B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers., [UniProtKB]; Fabp7 is a downstream gene of Pax6 transcription factor in the developing rat cortex and essential for maintenance of neuroepithelial cells during early cortical development., [RefSeq, PubMed]; The data of this study suggested that regional accumulations of FABP7+ astrocytes may represent reservoirs of cells having the potential for neurogenesis., [RefSeq, PubMed]; The results of the xenograft model assay showed that exogenous BLBP also stimulated tumor formation and downregulated p21 and p16. In conclusion, our study demonstrated that exogenous BLBP promoted proliferation of the C6 cells in vitro and facilitated tumor formation in vivo. Therefore, BLBP expression in glioma cells may promote cell growth by inhibiting the tumor suppressors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0043025 neuronal cell body;GO:0044297 cell body", "go_biological_process": "GO:0001964 startle response;GO:0060134 prepulse inhibition;GO:0015908 fatty acid transport;GO:0021846 cell proliferation in forebrain;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55051-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55062-1", "uniprot_id": "BI1_RAT", "mass": 26464.0, "length": 237, "protein_name": "Bax inhibitor 1", "gene_name": "Tmbim6", "organism": "Rat", "refseq_name": "bax inhibitor 1", "refseq_ac": "NP_062254", "gene_names_uniprotkb": "Tmbim6; Bi1; Tegt", "gene_names_refseq": "Ab1-011; Ac1-149; Cc1-27; Tegt; Tmbim6", "protein_names_uniprotkb": "Bax inhibitor 1; BI-1; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6", "protein_names_refseq": "BI-1; Bax inhibitor-1; bax inhibitor 1; testis enhanced gene transcript; testis-enhanced gene transcript protein; transmembrane BAX inhibitor motif-containing protein 6", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); invasive ductal carcinoma (Disease Ontology:DOID:3008); cervical squamous cell carcinoma (Disease Ontology:DOID:3744)", "pathway": " (rno:24822)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "29169414;30226536;36747144;37814860;8012111", "class_list": "", "function": "Bax inhibitor-1 (BI-1) over-expression improved neurobehavioral score, decreased hippocampal neuron apoptosis rate, and also down-regulated IRE1 protein levels in the rats with subarachnoid hemorrhage (SAH)., [RefSeq, PubMed]; Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria. Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; The present study suggested that Bax inhibitor-1 serves a neuroprotective role in Early brain injury following subarachnoid hemorrhage by attenuating bloodbrain barrier disruption, brain edema and apoptosis mediated by endoplasmic reticulum stress. Erratum:[Int J Mol Med. 2024 Apr;53(4):38. doi: 10.3892/ijmm.2024.5362. PMID: 38426556], [RefSeq, PubMed]; [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64712;Q6PDV4", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0019899 enzyme binding;GO:0031625 ubiquitin protein ligase binding;GO:0060698 endoribonuclease inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0043066 negative regulation of apoptotic process;GO:0030324 lung development;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P55062-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55207-1", "uniprot_id": "ANFC_RAT", "mass": 13314.0, "length": 126, "protein_name": "C-type natriuretic peptide", "gene_name": "Nppc", "organism": "Rat", "refseq_name": "C-type natriuretic peptide precursor", "refseq_ac": "NP_446202", "gene_names_uniprotkb": "Nppc; Cnp", "gene_names_refseq": "Nppc", "protein_names_uniprotkb": "C-type natriuretic peptide", "protein_names_refseq": "C-type natriuretic peptide precursor; C-type natriuretic peptide; natriuretic peptide precursor C; natriuretic peptide precursor type C", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); toxic shock syndrome (Disease Ontology:DOID:14115); depressive disorder (Disease Ontology:DOID:1596); aortic valve stenosis (Disease Ontology:DOID:1712); osteochondrodysplasia (Disease Ontology:DOID:2256); arteriosclerosis (Disease Ontology:DOID:2349); achondroplasia (Disease Ontology:DOID:4480); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:114593); (R-RNO-5578768)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1702395;30235256;32517762;33970224;37493451", "class_list": "", "function": "C-type natriuretic peptide induces inotropic and lusitropic effects in human 3D-engineered cardiac tissue: Implications for the regulation of cardiac function in humans., [RefSeq, PubMed]; C-type natriuretic peptide stimulates osteoblastic proliferation and collagen-X expression but suppresses fibroblast growth factor-23 expression in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors., [RefSeq, PubMed]; CNP-KO rats might be a valuable animal model for investigating growth plate physiology and the mechanism of growth plate closure. Publication Status: Online-Only, [RefSeq, PubMed]; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0051427 hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0032991 protein-containing complex", "go_biological_process": "GO:0035483 gastric emptying;GO:0001525 angiogenesis;GO:0002931 response to ischemia;GO:0006182 cGMP biosynthetic process;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P55207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56374-1", "uniprot_id": "CRBA4_RAT", "mass": 22382.0, "length": 196, "protein_name": "Beta-crystallin A4", "gene_name": "Cryba4", "organism": "Rat", "refseq_name": "beta-crystallin A4", "refseq_ac": "NP_113877", "gene_names_uniprotkb": "Cryba4", "gene_names_refseq": "Cryba4", "protein_names_uniprotkb": "Beta-crystallin A4; Beta-A4 crystallin", "protein_names_refseq": "beta-A4 crystallin; beta-crystallin A4", "tax_id": 10116, "disease": "cataract 23 (Disease Ontology:DOID:0110271); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:64348)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11773034;8405363", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0043010 camera-type eye development;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P56374-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56571-1", "uniprot_id": "ES1_RAT", "mass": 28173.0, "length": 266, "protein_name": "ES1 protein homolog, mitochondrial", "gene_name": "Gatd3a", "organism": "Rat", "refseq_name": "ES1 protein homolog, mitochondrial precursor", "refseq_ac": "NP_001004225", "gene_names_uniprotkb": "Gatd3a", "gene_names_refseq": "C21orf33; ES1; Gatd3a; RGD1303003", "protein_names_uniprotkb": "ES1 protein homolog, mitochondrial", "protein_names_refseq": "ES1 protein homolog, mitochondrial precursor; ES1 protein homolog, mitochondrial; glutamine amidotransferase like class 1 domain containing 3A; homolog of zebrafish ES1", "tax_id": 10116, "disease": "", "pathway": " (rno:294326)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10344264;34502162", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68FS5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P56571-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59645-1", "uniprot_id": "FXYD3_RAT", "mass": 9411.0, "length": 88, "protein_name": "FXYD domain-containing ion transport regulator 3", "gene_name": "Fxyd3", "organism": "Rat", "refseq_name": "FXYD domain-containing ion transport regulator 3 precursor", "refseq_ac": "NP_758528", "gene_names_uniprotkb": "Fxyd3", "gene_names_refseq": "Fxyd3; MAT8", "protein_names_uniprotkb": "FXYD domain-containing ion transport regulator 3; Sodium/potassium-transporting ATPase subunit FXYD3", "protein_names_refseq": "FXYD domain-containing ion transport regulator 3 precursor; sodium/potassium-transporting ATPase subunit FXYD3", "tax_id": 10116, "disease": "", "pathway": " (rno:116831); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10950925", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes., [UniProtKB, UniProtKB]; This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0050790 regulation of catalytic activity;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P59645-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59647-1", "uniprot_id": "FXYD5_RAT", "mass": 19128.0, "length": 178, "protein_name": "FXYD domain-containing ion transport regulator 5", "gene_name": "Fxyd5", "organism": "Rat", "refseq_name": "FXYD domain-containing ion transport regulator 5 precursor", "refseq_ac": "NP_001257617", "gene_names_uniprotkb": "Fxyd5", "gene_names_refseq": "Fxyd5; RIC", "protein_names_uniprotkb": "FXYD domain-containing ion transport regulator 5", "protein_names_refseq": "FXYD domain-containing ion transport regulator 5 precursor; oncoprotein induced transcript 2", "tax_id": 10116, "disease": "", "pathway": " (rno:60338)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10950925;22085977;35042436", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). May increase NKA activity by increasing the apparent affinity for Na(+). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; FXYD domain containing ion transport regulator 5 (FXYD5) silencing promotes cell viability and alleviates inflammatory response in cerulein-induced AR42J cells by blocking JAK2/STAT3 signaling pathway., [RefSeq, PubMed]; FXYD5 may have profound impact on the regulation of blood pressure., [RefSeq, PubMed]; This reference sequence was derived from multiple replicate ESTs and validated by similar mouse cDNA sequence and human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Three transcript variants encoding the same protein have been found for this gene. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9W0", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0015459 potassium channel regulator activity;GO:0017080 sodium channel regulator activity;GO:0045296 cadherin binding;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane;GO:0043269 regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P59647-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59722-1", "uniprot_id": "EGLN1_RAT", "mass": 36093.0, "length": 338, "protein_name": "Egl nine homolog 1", "gene_name": "Egln1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Egln1", "gene_names_refseq": "", "protein_names_uniprotkb": "Egl nine homolog 1; 1.14.11.29; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; Hypoxia-inducible factor prolyl hydroxylase 2; PHD2; Prolyl hydroxylase domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "familial erythrocytosis 3 (Disease Ontology:DOID:0080338); hypertension (Disease Ontology:DOID:10763); acute kidney failure (Disease Ontology:DOID:3021); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); polycythemia (Disease Ontology:DOID:8432)", "pathway": " (R-RNO-1234176)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12586829;12876291;16765982", "class_list": "", "function": "Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q642G6", "ec_number_list": "2.3.2.32;2.3.2.24;2.3.2.23;1.14.11.29;3.4.25.1;1.14.11.-", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:1902072 negative regulation of hypoxia-inducible factor-1alpha signaling pathway;GO:1905290 negative regulation of CAMKK-AMPK signaling cascade;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P59722-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60841-1", "uniprot_id": "ENSA_RAT", "mass": 13335.0, "length": 121, "protein_name": "Alpha-endosulfine", "gene_name": "Ensa", "organism": "Rat", "refseq_name": "alpha-endosulfine isoform 1", "refseq_ac": "NP_001029146", "gene_names_uniprotkb": "Ensa", "gene_names_refseq": "Ensa", "protein_names_uniprotkb": "Alpha-endosulfine; ARPP-19e", "protein_names_refseq": "ARPP-19e; alpha-endosulfine isoform 1; alpha-endosulfine", "tax_id": 10116, "disease": "", "pathway": " (rno:60334)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11279279;12107751;14622089;15086912;22673903;28922851;29393594;9653196", "class_list": "", "function": "ENSA and alpha-endosulfine are expressed in glomeruli and mesangial cells, and gene and protein expression are up-regulated by a high glucose environment., [RefSeq, PubMed]; Localization in pancreatic somatostatin delta cells and expression during rat pancreas development, [RefSeq, PubMed]; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that alpha-endosulfine gene expression is differentially regulated by distinct brain processes involving excitatory neuronal activities, [RefSeq, PubMed]; This study demonstrated that the alphaEnsa levels are significantly upregulated in mammalian brain at various times following the onset of ischemia/reperfusion. Protein upregulation was detected as early as 2 hours after ischemic onset, with sustained upregulation noted subsequently over several days, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCU7;Q9CQZ9;Q9Z0G1", "ec_number_list": "", "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0005102 signaling receptor binding;GO:0015459 potassium channel regulator activity;GO:0019888 protein phosphatase regulator activity;GO:0051721 protein phosphatase 2A binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0050796 regulation of insulin secretion;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P60841-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61016-1", "uniprot_id": "PPLA_RAT", "mass": 6095.0, "length": 52, "protein_name": "Phospholamban", "gene_name": "Pln", "organism": "Rat", "refseq_name": "phospholamban", "refseq_ac": "NP_073198", "gene_names_uniprotkb": "Pln", "gene_names_refseq": "Plm; Pln", "protein_names_uniprotkb": "Phospholamban; PLB", "protein_names_refseq": "PLB; cardiac phospholamban; phospholamban", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy 18 (Disease Ontology:DOID:0110324); dilated cardiomyopathy 1P (Disease Ontology:DOID:0110439); heart disease (Disease Ontology:DOID:114); centronuclear myopathy (Disease Ontology:DOID:14717); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:64672); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 35, "publication_id_list": "10532953;10997724;11827689;12933346;1445334;14577598;15524173;15637115;17239900;1725098;17305702;17827263;20484118;22673903;23781262;23923043;24748367;25488774;27206677;27520671;28536695;28656205;28955223;29045568;29913456;29921042;32039693;32665640;32714085;32920522;33220932;33488937;33897445;36207382;8508530", "class_list": "", "function": "Cardioprotection by PKN1 is associated with reduced CamKIIdelta-dependent phospholamban Thr17 phosphorylation at the SR and therefore may stabilize the coupling of SR Ca2+ handling and contractile function, independent of its kinase activity., [RefSeq, PubMed]; Long-term in vivo administration of GTE improves cell mechanical properties and intracellular calcium dynamics in normal cardiomyocytes, by increasing energy availability and removing the inhibitory effect of PLB on SERCA2., [RefSeq, PubMed]; Myocardial Dysfunction in Cirrhotic Cardiomyopathy is Associated with Alterations of Phospholamban Phosphorylation and IL-6 Levels., [RefSeq, PubMed]; Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle. Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Also inhibits the activity of ATP2A3/SERCA3. Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation. In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P20006", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044325 transmembrane transporter binding;GO:0042030 ATPase inhibitor activity;GO:0141110 transporter inhibitor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031982 vesicle;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0090279 regulation of calcium ion import;GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity;GO:0086092 regulation of the force of heart contraction by cardiac conduction;GO:1901895 negative regulation of ATPase-coupled calcium transmembrane transporter activity;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P61016-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61751-1", "uniprot_id": "ARF4_RAT", "mass": 20397.0, "length": 180, "protein_name": "ADP-ribosylation factor 4", "gene_name": "Arf4", "organism": "Rat", "refseq_name": "ADP-ribosylation factor 4", "refseq_ac": "NP_077065", "gene_names_uniprotkb": "Arf4", "gene_names_refseq": "Arf4", "protein_names_uniprotkb": "ADP-ribosylation factor 4", "protein_names_refseq": "ADP-ribosylation factor 4", "tax_id": 10116, "disease": "", "pathway": " (rno:79120); (R-RNO-5620916); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "1358888;8813705", "class_list": "", "function": "GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P36403", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005154 epidermal growth factor receptor binding;GO:1990583 phospholipase D activator activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007612 learning;GO:0016477 cell migration;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61751-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62510-1", "uniprot_id": "ERR3_RAT", "mass": 51306.0, "length": 458, "protein_name": "Estrogen-related receptor gamma", "gene_name": "Esrrg", "organism": "Rat", "refseq_name": "estrogen-related receptor gamma isoform 2", "refseq_ac": "NP_976081", "gene_names_uniprotkb": "Esrrg; Errg; Nr3b3", "gene_names_refseq": "Esrrg; errg", "protein_names_uniprotkb": "Estrogen-related receptor gamma; Estrogen receptor-related protein 3; Nuclear receptor subfamily 3 group B member 3", "protein_names_refseq": "estrogen receptor-related protein 3; estrogen-related receptor gamma isoform 2; nuclear receptor subfamily 3 group B member 3", "tax_id": 10116, "disease": "azoospermia (Disease Ontology:DOID:14227); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:360896); (R-RNO-383280)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15475169;17079227;21911493;23404793;26404484;36481985", "class_list": "", "function": "ERRgamma plays a key role in vascular calcification by upregulating the BMP2 signaling pathway., [RefSeq, PubMed]; ERRgamma recognizes a tremendously broad range of sequences as a homodimer., [RefSeq, PubMed]; ERRgamma was preferentially expressed in brown compared to white fat depots, and ERRgamma was induced during cold-induced browning of subcutaneous white adipose tissue and brown adipogenesis, [RefSeq, PubMed]; Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling, [RefSeq, PubMed]; Estrogen-related receptor gamma binds to the hepatic pyruvate dehydrogenase kinase (PDK) 4 promoter and stimulates PDK4 expression., [RefSeq, PubMed]; Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle (By similarity)., [UniProtKB]; Role of Estrogen-Related Receptor gamma and PGC-1alpha/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage. Erratum:[Neurotherapeutics. 2023 Apr;20(3):908. doi: 10.1007/s13311-022-01340-6. PMID: 36637772], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5QJE4;Q75T51;Q75T52", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003707 nuclear steroid receptor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62510-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62630-1", "uniprot_id": "EF1A1_RAT", "mass": 50114.0, "length": 462, "protein_name": "Elongation factor 1-alpha 1", "gene_name": "Eef1a1", "organism": "Rat", "refseq_name": "elongation factor 1-alpha 1", "refseq_ac": "NP_787032", "gene_names_uniprotkb": "Eef1a1; Eef1a", "gene_names_refseq": "EEF-1; EEF1A; EF1A; Eef1a1; Eef1a2l1; Eef1a2; SI", "protein_names_uniprotkb": "Elongation factor 1-alpha 1; 3.6.5.-; EF-1-alpha-1; EF-Tu; Elongation factor Tu; Eukaryotic elongation factor 1 A-1; eEF1A-1", "protein_names_refseq": "EF-1 alpha2; EF-1-alpha-1; EF-Tu; eEF1A-1; elongation factor 1 A-1; elongation factor 1-alpha 1; elongation factor Tu; eukaryotic elongation factor 1 A-1; eukaryotic translation elongation factor 1 alpha 2 like 1", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 33 (Disease Ontology:DOID:0080463); dilated cardiomyopathy (Disease Ontology:DOID:12930); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:171361); (R-RNO-156842); (R-RNO-3371511); (R-RNO-6798695); (R-RNO-8876725)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "1542580;1730661;1762922;18683930;31468715;38843836;7945283", "class_list": "", "function": "Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (By similarity). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20001;Q5BJW8;Q64718;Q78ED4", "ec_number_list": "3.6.5.2;2.1.1.-;3.6.1.1;3.6.5.-;5.2.1.8;3.6.5.3;2.3.2.27;1.1.1.205;3.2.1.23;3.5.4.5;2.3.2.5;3.6.4.13;2.4.1.25;3.2.1.33;4.2.99.18;5.6.2.4;2.7.11.1;4.1.2.4;2.4.1.186;3.5.4.6;3.1.1.47;3.6.5.5;2.7.1.35;3.6.1.5;3.4.22.1;1.11.1.6;2.5.1.18;4.1.2.13;4.2.1.24;3.2.1.31;2.4.1.1;2.7.10.2;2.7.1.40;1.13.11.-;1.13.11.34;3.4.19.1;2.3.3.8;1.16.3.1;2.7.4.6;2.7.13.3;3.4.23.5;5.4.2.11;5.4.2.4;2.7.1.1;3.3.2.6;3.4.11.4;2.7.1.11;5.3.2.1;5.3.3.12;3.4.21.46;3.1.6.4;2.4.2.7;5.4.2.2;1.1.1.42;3.6.4.6;3.4.24.35;3.1.6.12;2.3.2.26;3.6.4.10;2.7.11.24;2.4.2.1;3.4.22.52;3.4.22.27;3.6.1.-;2.7.11.39;3.6.5.4;5.3.1.9;5.1.3.-;3.5.1.23;3.5.1.-;3.6.1.6;3.4.25.1;3.4.18.1;1.11.1.24", "go_molecular_function": "GO:0019209 kinase activator activity;GO:0060090 molecular adaptor activity;GO:0003729 mRNA binding;GO:0003924 GTPase activity;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0010976 positive regulation of neuron projection development;GO:0043065 positive regulation of apoptotic process;GO:1990090 cellular response to nerve growth factor stimulus;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P62630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62697-1", "uniprot_id": "CRBB2_RAT", "mass": 23381.0, "length": 205, "protein_name": "Beta-crystallin B2", "gene_name": "Crybb2", "organism": "Rat", "refseq_name": "beta-crystallin B2", "refseq_ac": "NP_037069", "gene_names_uniprotkb": "Crybb2", "gene_names_refseq": "Crybb2", "protein_names_uniprotkb": "Beta-crystallin B2; Beta-B2 crystallin; Beta-crystallin Bp", "protein_names_refseq": "R.norvegicus CRYBB2 gene (crystallin, beta B2); beta-B2 crystallin; beta-crystallin B2; beta-crystallin Bp", "tax_id": 10116, "disease": "cataract 20 multiple types (Disease Ontology:DOID:0110240); cataract 3 multiple types (Disease Ontology:DOID:0110269); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:25422)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11773034;17264069;2753045;8405363;9655330", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]; These data are the first to show that axonal regeneration is related to crybb2 movement., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P19942;P26775", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0043010 camera-type eye development;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62697-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62744-1", "uniprot_id": "AP2S1_RAT", "mass": 17018.0, "length": 142, "protein_name": "AP-2 complex subunit sigma", "gene_name": "Ap2s1", "organism": "Rat", "refseq_name": "AP-2 complex subunit sigma", "refseq_ac": "NP_075241", "gene_names_uniprotkb": "Ap2s1; Ap17; Claps2", "gene_names_refseq": "Ap17; Ap2s1", "protein_names_uniprotkb": "AP-2 complex subunit sigma; Adaptor protein complex AP-2 subunit sigma; Adaptor-related protein complex 2 subunit sigma; Clathrin assembly protein 2 sigma small chain; Clathrin coat assembly protein AP17; Clathrin coat-associated protein AP17; Plasma membrane adaptor AP-2 17 kDa protein; Sigma-adaptin 3b; Sigma2-adaptin", "protein_names_refseq": "AP-2 complex subunit sigma; adapter-related protein complex 2 sigma subunit; adapter-related protein complex 2 subunit sigma; adaptor protein complex AP-2 subunit sigma; adaptor-related protein complex 2 subunit sigma; adaptor-related protein complex 2, sigma 1 subunit; clathrin assembly protein 2 sigma small chain; clathrin assembly protein 2 small chain; clathrin coat assembly protein AP17; clathrin coat-associated protein AP17; clathrin-associated protein 17; plasma membrane adaptor AP-2 17 kDa protein; sigma-adaptin 3b; sigma2-adaptin", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); familial hypocalciuric hypercalcemia 3 (Disease Ontology:DOID:0060702)", "pathway": " (rno:65046); (R-RNO-177504); (R-RNO-2132295); (R-RNO-416993); (R-RNO-437239); (R-RNO-5099900); (R-RNO-5140745); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8866427); (R-RNO-8964038)", "pathway_count": 11, "publication_count": 4, "publication_id_list": "10559001;14745134;15473838;2040623", "class_list": "", "function": "Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. May also play a role in extracellular calcium homeostasis (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70626;P97626;Q00380", "ec_number_list": "", "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0098794 postsynapse;GO:0030122 AP-2 adaptor complex", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62744-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62950-1", "uniprot_id": "BLCAP_RAT", "mass": 9876.0, "length": 87, "protein_name": "Apoptosis inducing factor BLCAP", "gene_name": "Blcap", "organism": "Rat", "refseq_name": "apoptosis inducing factor BLCAP", "refseq_ac": "NP_598266", "gene_names_uniprotkb": "Blcap", "gene_names_refseq": "Blcap", "protein_names_uniprotkb": "Apoptosis inducing factor BLCAP; Bc10; Bladder cancer 10 kDa protein; Bladder cancer-associated protein", "protein_names_refseq": "apoptosis inducing factor BLCAP; bc10; bladder cancer 10 kDa protein; bladder cancer associated protein homolog; bladder cancer-associated protein", "tax_id": 10116, "disease": "", "pathway": " (rno:171113)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a tumor suppressor; induces growth arrest at G(1)/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mechanisms. Modulates expression of genes involved in the regulation of proliferation, cell cycle and apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O60629;Q9D3B5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0030262 apoptotic nuclear changes", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P62950-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63041-1", "uniprot_id": "CPLX1_RAT", "mass": 15122.0, "length": 134, "protein_name": "Complexin-1", "gene_name": "Cplx1", "organism": "Rat", "refseq_name": "complexin-1", "refseq_ac": "NP_074055", "gene_names_uniprotkb": "Cplx1", "gene_names_refseq": "Cplx1", "protein_names_uniprotkb": "Complexin-1; CPX I; Complexin I; Synaphin-2", "protein_names_refseq": "CPX I; complexin I; complexin-1; synaphin-2", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 63 (Disease Ontology:DOID:0080426); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:64832); (R-RNO-181429); (R-RNO-181430); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642); (R-RNO-888590)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "10051208;10430466;10777504;11751907;11832227;15911881;27821736;29985126;30194295;31875236;36675068;7553862;9753100", "class_list": "", "function": "Actively drives SNARE complexes into linker-open conformation Publication Status: Online-Only, [RefSeq, PubMed]; Complexin I knockout rats exhibit a complex neurobehavioral phenotype including profound ataxia and marked deficits in lifespan., [RefSeq, PubMed]; Complexin-1 competes with alphaSNAP binding to the SNARE complex. Publication Status: Online-Only, [RefSeq, PubMed]; Involvement of miR-135a-5p Downregulation in Acute and Chronic Stress Response in the Prefrontal Cortex of Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior., [UniProtKB, UniProtKB]; Results suggest that the C-terminal domain of Cplx1 plays a role in preferential membrane localization of Cpx to synaptic vesicles and find it as an important regulator for synaptic vesicle fusion through promoting Ca2+ in conjunction with SNAREs and synaptotagmins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09057;O09142;Q566D7;Q64276", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0000149 SNARE binding;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0030073 insulin secretion;GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0016079 synaptic vesicle exocytosis;GO:0099145 regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P63041-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63170-1", "uniprot_id": "DYL1_RAT", "mass": 10366.0, "length": 89, "protein_name": "Dynein light chain 1, cytoplasmic", "gene_name": "Dynll1", "organism": "Rat", "refseq_name": "dynein light chain 1, cytoplasmic", "refseq_ac": "NP_445771", "gene_names_uniprotkb": "Dynll1; Dncl1; Dnclc1; Pin", "gene_names_refseq": "8kDLC; Dlc8; Dnclc1; Dynll1; Pin", "protein_names_uniprotkb": "Dynein light chain 1, cytoplasmic; 8 kDa dynein light chain; DLC8; Dynein light chain LC8-type 1; PIN; Protein inhibitor of neuronal nitric oxide synthase", "protein_names_refseq": "8 kDa dynein light chain; 8kD LC; dynein LC8; dynein light chain 1, cytoplasmic; dynein, cytoplasmic, light chain 1; protein inhibitor of neuronal nitric oxide synthase", "tax_id": 10116, "disease": "cardiac arrest (Disease Ontology:DOID:0060319); hypertension (Disease Ontology:DOID:10763); impotence (Disease Ontology:DOID:1875); middle cerebral artery infarction (Disease Ontology:DOID:3525); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:58945); (R-RNO-111446); (R-RNO-141430); (R-RNO-141444); (R-RNO-1632852); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-3371497); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-5620924); (R-RNO-5663220); (R-RNO-6798695); (R-RNO-6807878); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8854518); (R-RNO-9646399); (R-RNO-9648025)", "pathway_count": 24, "publication_count": 11, "publication_id_list": "11178896;11602781;11746667;16133941;21478148;24958506;26459761;30018294;8702622;8864115;9299562", "class_list": "", "function": "Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:11746667, PubMed:8702622). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:11746667, PubMed:8702622). May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (PubMed:11746667, PubMed:8702622). In addition to its role in cytoskeleton and transport, acts as a protein-protein adapter, which inhibits and/or sequesters target proteins (By similarity). Involved in the response to DNA damage by acting as a key regulator of DNA end resection: when phosphorylated at Ser-88, recruited to DNA double-strand breaks (DSBs) by TP53BP1 and acts by disrupting MRE11 dimerization, thereby inhibiting DNA end resection (By similarity). In a subset of DSBs, DYNLL1 remains unphosphorylated and promotes the recruitment of the Shieldin complex (By similarity). Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1 (PubMed:8864115). Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1 (By similarity). Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules (By similarity). Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Data suggest that redox-sensitive and protein inhibitor of nNOS (PIN)-mediated neuronal NO synthase (nNOS) uncoupling is engaged in a vicious cycle that sustains the production of reactive oxygen species in rostral ventrolateral medulla (RVLM)., [RefSeq, PubMed]; It has been found that APC2 localizes as distinct clusters along microtubule bundles in dendrites, and that this localization is driven by LC8-binding and two separate microtubule-interacting domains. Publication Status: Online-Only, [RefSeq, PubMed]; Silencing of Dynein light chain LC8 or class I transcription factor A2 resulted in a loss of CITFA from RNA Pol I promoters Erratum:[Mol Cell Biol. 2017 May 31;37(12):e00166-17. doi: 10.1128/MCB.00166-17. PMID: 28566454] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q15701", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0051881 regulation of mitochondrial membrane potential;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P63170-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63255-1", "uniprot_id": "CRIP1_RAT", "mass": 8550.0, "length": 77, "protein_name": "Cysteine-rich protein 1", "gene_name": "Crip1", "organism": "Rat", "refseq_name": "cysteine-rich protein 1", "refseq_ac": "NP_001128405", "gene_names_uniprotkb": "Crip1; Crip", "gene_names_refseq": "Crip1; Crip; Crp-1", "protein_names_uniprotkb": "Cysteine-rich protein 1; CRIP; CRP-1; Cysteine-rich intestinal protein", "protein_names_refseq": "cysteine-rich intestinal protein; cysteine-rich protein 1 (intestinal); cysteine-rich protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:691657)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1946385;3085096;8632452", "class_list": "", "function": "Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04006", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042277 peptide binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0060741 prostate gland stromal morphogenesis;GO:0006955 immune response;GO:0010043 response to zinc ion;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P63255-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63269-1", "uniprot_id": "ACTH_RAT", "mass": 41877.0, "length": 376, "protein_name": "Actin, gamma-enteric smooth muscle", "gene_name": "Actg2", "organism": "Rat", "refseq_name": "actin, gamma-enteric smooth muscle", "refseq_ac": "NP_037025", "gene_names_uniprotkb": "Actg2; Acta3; Actsg", "gene_names_refseq": "ACTGE; Actg2; SMGA", "protein_names_uniprotkb": "Actin, gamma-enteric smooth muscle; 3.6.4.-; Alpha-actin-3; Gamma-2-actin; Smooth muscle gamma-actin", "protein_names_refseq": "actin, gamma 2, smooth muscle, enteric; actin, gamma-enteric smooth muscle; alpha-actin-3; alpha-smooth muscle actin; gamma-2-actin; gamma-enteric smooth muscle actin; smooth muscle gamma-actin", "tax_id": 10116, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); Bartter disease type 3 (Disease Ontology:DOID:0110144); Bartter disease type 4b (Disease Ontology:DOID:0110146); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); myopathy (Disease Ontology:DOID:423); Bartter disease (Disease Ontology:DOID:445)", "pathway": " (rno:25365); (R-RNO-445355); (R-RNO-9764561); (R-RNO-9913351); (R-RNO-9958825)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "22165288;31484043;3244353", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]; Assessment of renal fibrosis in a rat model of unilateral ureteral obstruction with diffusion kurtosis imaging: Comparison with alpha-SMA expression and (18)F-FDG PET., [RefSeq, PubMed]; Hepatocyte growth factor-induced amelioration in renal interstitial fibrosis is associated with reduced expression of alpha-smooth muscle actin and transforming growth factor-beta1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P12718", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;2.3.2.31;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;3.6.5.-;5.6.2.-;2.3.2.26;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.1.4.-;3.6.5.2;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium;GO:0044297 cell body", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0045471 response to ethanol;GO:0090131 mesenchyme migration;GO:0071354 cellular response to interleukin-6;GO:1905641 cellular response to acetaldehyde", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P63269-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P67874-1", "uniprot_id": "CSK2B_RAT", "mass": 24942.0, "length": 215, "protein_name": "Casein kinase II subunit beta", "gene_name": "Csnk2b", "organism": "Rat", "refseq_name": "casein kinase II subunit beta", "refseq_ac": "NP_001030315", "gene_names_uniprotkb": "Csnk2b; Ck2n", "gene_names_refseq": "Ck2; Csnk2b", "protein_names_uniprotkb": "Casein kinase II subunit beta; CK II beta; Phosvitin", "protein_names_refseq": "CK II beta; Csnk2b-Ly6g5b; casein kinase 2, beta polypeptide; casein kinase 2, beta subunit; casein kinase II beta subunit; casein kinase II subunit beta; phosvitin", "tax_id": 10116, "disease": "leiomyoma (Disease Ontology:DOID:127); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:81650); (R-RNO-1483191); (R-RNO-201688); (R-RNO-2514853); (R-RNO-445144); (R-RNO-6798695); (R-RNO-6804756); (R-RNO-6814122); (R-RNO-8934903); (R-RNO-8939243); (R-RNO-8948751); (R-RNO-9768727); (R-RNO-9929491)", "pathway_count": 13, "publication_count": 9, "publication_id_list": "15060004;16818610;22673903;27782092;27851782;34884938;34948351;38381246;8173590", "class_list": "", "function": "ANXA1 promotes microglial activation and migration during oxygen-glucose deprivation/reperfusion via FPR, and CK2 target alpha-E-catenin phosphorylation is involved in this process. Publication Status: Online-Only, [RefSeq, PubMed]; AlphaB-crystallin protects rat articular chondrocytes against CK2 inhibition-induced apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; CK2 Phosphorylation Is Required for Regulation of Syntaxin 1A Activity in Ca(2+)-Triggered Release in Neuroendocrine Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic beta-Cells of the Line INS-1. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation., [RefSeq, PubMed]; Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:16818610). Participates in Wnt signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P07312;P13862", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016363 nuclear matrix", "go_biological_process": "GO:0016310 phosphorylation;GO:0043537 negative regulation of blood vessel endothelial cell migration;GO:0016055 Wnt signaling pathway;GO:0033211 adiponectin-activated signaling pathway;GO:0032927 positive regulation of activin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P67874-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P68313-1", "uniprot_id": "ERTS_RAT", "mass": 7837.0, "length": 68, "protein_name": "Erythrodihydroneopterin triphosphate synthetase", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Erythrodihydroneopterin triphosphate synthetase; 6.-.-.-", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "697844", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P00972", "ec_number_list": "", "go_molecular_function": "GO:0016874 ligase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P68313-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P69527-1", "uniprot_id": "AMPO_RAT", "mass": 93432.0, "length": 822, "protein_name": "Aminopeptidase O", "gene_name": "Aopep", "organism": "Rat", "refseq_name": "aminopeptidase O", "refseq_ac": "NP_001012346", "gene_names_uniprotkb": "Aopep; Onpep", "gene_names_refseq": "Aopep; Apo; Npepo; RGD1309592", "protein_names_uniprotkb": "Aminopeptidase O; 3.4.11.-; AP-O", "protein_names_refseq": "AP-O; aminopeptidase O", "tax_id": 10116, "disease": "dystonia 31 (Disease Ontology:DOID:0060938)", "pathway": " (rno:290963)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LRV1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P69527-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P69736-1", "uniprot_id": "EDF1_RAT", "mass": 16369.0, "length": 148, "protein_name": "Endothelial differentiation-related factor 1", "gene_name": "Edf1", "organism": "Rat", "refseq_name": "endothelial differentiation-related factor 1", "refseq_ac": "NP_001100027", "gene_names_uniprotkb": "Edf1", "gene_names_refseq": "CAP-19; Edf1", "protein_names_uniprotkb": "Endothelial differentiation-related factor 1; CAP-19; Calmodulin-associated peptide 19; EDF-1; MBF1; Multiprotein-bridging factor 1", "protein_names_refseq": "EDF-1; MBF1; calmodulin-associated peptide-19; endothelial differentiation-related factor 1 homolog; endothelial differentiation-related factor 1; multiprotein-bridging factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:296570)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12729799;9795107", "class_list": "", "function": "Data suggest that multiprotein bridging factor 1 is a transcriptional coactivator of c-Jun regulating hypertrophic gene expression [MBF1], [RefSeq, PubMed]; Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0005516 calmodulin binding;GO:0001094 TFIID-class transcription factor complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P69736-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70505-1", "uniprot_id": "ADAM1_RAT", "mass": 86140.0, "length": 789, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 1", "gene_name": "Adam1a; Adam1", "organism": "Rat", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 1 precursor", "refseq_ac": "NP_064463", "gene_names_uniprotkb": "Adam1a; Adam1; Adam1a; Ftna", "gene_names_refseq": "Adam1a; Adam1; PH-30a", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 1; 3.4.24.-; ADAM 1; Fertilin subunit alpha", "protein_names_refseq": "ADAM 1; PH-30 alpha; a disintegrin and metallopeptidase domain 1a; a disintegrin and metalloprotease domain 1 (fertilin alpha); a disintegrin and metalloproteinase domain 1 (fertilin alpha); disintegrin and metalloproteinase domain-containing protein 1 precursor; disintegrin and metalloproteinase domain-containing protein 1; fertilin subunit alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:56777)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9358007", "class_list": "", "function": "May be involved in sperm-egg fusion., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:1990913 sperm head plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007339 binding of sperm to zona pellucida;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P70505-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70541-1", "uniprot_id": "EI2BG_RAT", "mass": 50435.0, "length": 452, "protein_name": "Translation initiation factor eIF2B subunit gamma", "gene_name": "Eif2b3", "organism": "Rat", "refseq_name": "translation initiation factor eIF2B subunit gamma", "refseq_ac": "NP_598293", "gene_names_uniprotkb": "Eif2b3; Eif2bg", "gene_names_refseq": "Eif2b3", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit gamma; eIF2B GDP-GTP exchange factor subunit gamma", "protein_names_refseq": "eIF-2B GDP-GTP exchange factor subunit gamma; eIF2B GDP-GTP exchange factor subunit gamma; eukaryotic translation initiation factor 2B, subunit 3 (gamma, 58kD); eukaryotic translation initiation factor 2B, subunit 3 gamma; translation initiation factor eIF-2B subunit gamma; translation initiation factor eIF2B subunit gamma", "tax_id": 10116, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 3 (Disease Ontology:DOID:0070372)", "pathway": " (rno:171145); (R-RNO-72731)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29393594;8809057", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IN08", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0021766 hippocampus development;GO:0050852 T cell receptor signaling pathway;GO:0006413 translational initiation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70541-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70562-1", "uniprot_id": "BHA15_RAT", "mass": 22196.0, "length": 197, "protein_name": "Class A basic helix-loop-helix protein 15", "gene_name": "Bhlha15", "organism": "Rat", "refseq_name": "class A basic helix-loop-helix protein 15", "refseq_ac": "NP_036995", "gene_names_uniprotkb": "Bhlha15; Bhlhb8; Mist1", "gene_names_refseq": "Bhlha15; Bhlhb8; Mist1; bHlH", "protein_names_uniprotkb": "Class A basic helix-loop-helix protein 15; Class B basic helix-loop-helix protein 8; MIST-1; Muscle, intestine and stomach expression 1; bHLHa15; bHLHb8", "protein_names_refseq": "Basic helix-loop-helix transcription factor (bHlH); MIST-1; basic helix-loop-helix domain containing, class B, 8; class A basic helix-loop-helix protein 15; class B basic helix-loop-helix protein 8; muscle, intestine and stomach expression 1", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 7 (Disease Ontology:DOID:0070037); intellectual disability (Disease Ontology:DOID:1059); dilated cardiomyopathy (Disease Ontology:DOID:12930); Down syndrome (Disease Ontology:DOID:14250); renovascular hypertension (Disease Ontology:DOID:1591); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (rno:25334)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10721714;15112319;17605298;22673903;9073453", "class_list": "", "function": "BHLH regulate ABP in differentiated Sertoli cells., [RefSeq, PubMed]; Data suggest that Mist1 activates exocrine-specific gene transcription through an acetylation mechanism., [RefSeq, PubMed]; Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007267 cell-cell signaling;GO:0019722 calcium-mediated signaling;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70562-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70611-1", "uniprot_id": "DOC2A_RAT", "mass": 44590.0, "length": 403, "protein_name": "Double C2-like domain-containing protein alpha", "gene_name": "Doc2a", "organism": "Rat", "refseq_name": "double C2-like domain-containing protein alpha", "refseq_ac": "NP_075226", "gene_names_uniprotkb": "Doc2a", "gene_names_refseq": "Doc2a", "protein_names_uniprotkb": "Double C2-like domain-containing protein alpha; Doc2-alpha", "protein_names_refseq": "doc2-alpha; double C2, alpha; double C2-like domain-containing protein alpha; double C2-like domains, alpha", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:65031)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18354201;9115738;9804756", "class_list": "", "function": "Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0045202 synapse;GO:0005764 lysosome;GO:0043005 neuron projection", "go_biological_process": "GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:0061669 spontaneous neurotransmitter secretion;GO:0016079 synaptic vesicle exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70611-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70623-1", "uniprot_id": "FABP4_RAT", "mass": 14708.0, "length": 132, "protein_name": "Fatty acid-binding protein, adipocyte", "gene_name": "Fabp4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fabp4", "gene_names_refseq": "", "protein_names_uniprotkb": "Fatty acid-binding protein, adipocyte; A-FABP; AFABP; ALBP; Adipocyte lipid-binding protein; Adipocyte-type fatty acid-binding protein; Fatty acid-binding protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); impotence (Disease Ontology:DOID:1875); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:79451); (R-RNO-163560)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;34502162", "class_list": "", "function": "Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding;GO:0051427 hormone receptor binding;GO:0060229 lipase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0008284 positive regulation of cell population proliferation;GO:0050872 white fat cell differentiation;GO:0050873 brown fat cell differentiation;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70623-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80203-1", "uniprot_id": "ACVL1_RAT", "mass": 56703.0, "length": 504, "protein_name": "Activin receptor type-1-like", "gene_name": "Acvrl1", "organism": "Rat", "refseq_name": "activin receptor type-1-like precursor", "refseq_ac": "NP_071886", "gene_names_uniprotkb": "Acvrl1; Acvrlk1", "gene_names_refseq": "Acvrl1; Alk1; R-3; R3; SETHKIR", "protein_names_uniprotkb": "Activin receptor type-1-like; 2.7.11.30; SKR3; Serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I; TSR-I", "protein_names_refseq": "Activin receptor like kinase 1; SKR3; TGF-B superfamily receptor type I; TSR-I; activin A receptor type II-like 1; activin A receptor type IL; activin receptor type-1-like precursor; activin receptor type-1-like; serine/threonine-protein kinase receptor R3", "tax_id": 10116, "disease": "arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); arteriovenous malformation (Disease Ontology:DOID:11294); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); fibrodysplasia ossificans progressiva (Disease Ontology:DOID:13374); transient cerebral ischemia (Disease Ontology:DOID:224); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:25237); (R-RNO-201451)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "22673903;25424912;26540443;30262595;31322216;8395914;8928814", "class_list": "", "function": "Increased expression of ALK-1 in the pulmonary vasculature of congenital diaphragmatic hernia (CDH) suggest that ALK-1 may play a crucial role in the molecular pathogenesis of vascular remodeling in CDH., [RefSeq, PubMed]; Oatp1a4 transport activity at the BBB is directly regulated by TGF-beta/ALK1 signaling., [RefSeq, PubMed]; Overexpression of Alk-5 and silencing of Alk-1 led to a loss of the chondrocyte phenotype, proving that they are key regulators of chondrocyte mechanosensing., [RefSeq, PubMed]; These results provided clear evidence that miR98 was a direct regulator of ALK1, and that the downregulation of miR98 contributed to the pathogenesis of hypoxic pulmonary hypertension., [RefSeq, PubMed]; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63559", "ec_number_list": "2.7.11.30", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0070724 BMP receptor complex", "go_biological_process": "GO:0030858 positive regulation of epithelial cell differentiation;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0006468 protein phosphorylation;GO:0007162 negative regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P80203-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80347-1", "uniprot_id": "FUC1_RAT", "mass": 2393.0, "length": 22, "protein_name": "Fuctinin-1", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Fuctinin-1; Fucosyltransferase inhibitor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8076650", "class_list": "", "function": "Has a role in the physiological regulation of fucosylation processes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80347-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80348-1", "uniprot_id": "FUC2_RAT", "mass": 2489.0, "length": 22, "protein_name": "Fuctinin-2", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Fuctinin-2; Fucosyltransferase inhibitor 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8076650", "class_list": "", "function": "Has a role in the physiological regulation of fucosylation processes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80348-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80349-1", "uniprot_id": "FUC3_RAT", "mass": 4480.0, "length": 39, "protein_name": "Fuctinin-3", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Fuctinin-3; Fucosyltransferase inhibitor 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8076650", "class_list": "", "function": "Has a role in the physiological regulation of fucosylation processes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80349-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84025-1", "uniprot_id": "SMAD3_RAT", "mass": 48081.0, "length": 425, "protein_name": "SMAD family member 3", "gene_name": "Smad3", "organism": "Rat", "refseq_name": "SMAD family member 3", "refseq_ac": "NP_037227", "gene_names_uniprotkb": "Smad3; Madh3", "gene_names_refseq": "Madh3; Smad 3; Smad3; mad3", "protein_names_uniprotkb": "SMAD family member 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; Mothers against decapentaplegic homolog 3; SMAD 3", "protein_names_refseq": "MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 3; SMAD family member 3; mothers against DPP homolog 3; mothers against decapentaplegic homolog 3", "tax_id": 10116, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); Loeys-Dietz syndrome 3 (Disease Ontology:DOID:0070237); prostate cancer (Disease Ontology:DOID:10283); hypospadias (Disease Ontology:DOID:10892); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); endometrial cancer (Disease Ontology:DOID:1380); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); pancreatic cancer (Disease Ontology:DOID:1793); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); osteoarthritis (Disease Ontology:DOID:8398); muscular dystrophy (Disease Ontology:DOID:9884); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:25631); (R-RNO-1181150); (R-RNO-1502540); (R-RNO-2173788); (R-RNO-2173789); (R-RNO-2173795); (R-RNO-2173796); (R-RNO-5689880); (R-RNO-8941855); (R-RNO-9617828)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "11274402;16619037;21791611;22073128;29783655;31035577;31557800;37921754;38122948;38690917;39105875;39168432;8917532", "class_list": "", "function": "Brachyury promotes extracellular matrix synthesis through transcriptional regulation of Smad3 in nucleus pulposus., [RefSeq, PubMed]; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity)., [UniProtKB, UniProtKB, PubMed]; Recombinant Slit2 attenuates tracheal fibroblast activation in benign central airway obstruction by inhibiting the TGF-beta1/Smad3 signaling pathway., [RefSeq, PubMed]; SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin II-induced atrial fibrosis and vulnerability to atrial fibrillation via suppression of the TGF-beta1/smad2/3 signalling pathway., [RefSeq, PubMed]; Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats., [RefSeq, PubMed]; Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-beta and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09064;O09144;O14510;O35273;Q92940;Q93002;Q9GKR4", "ec_number_list": "", "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0031962 nuclear mineralocorticoid receptor binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0030878 thyroid gland development;GO:0016202 regulation of striated muscle tissue development;GO:0071559 response to transforming growth factor beta;GO:0050678 regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P84025-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84079-1", "uniprot_id": "ARF1_RAT", "mass": 20697.0, "length": 181, "protein_name": "ADP-ribosylation factor 1", "gene_name": "Arf1", "organism": "Rat", "refseq_name": "ADP-ribosylation factor 1", "refseq_ac": "NP_071963", "gene_names_uniprotkb": "Arf1", "gene_names_refseq": "Arf1", "protein_names_uniprotkb": "ADP-ribosylation factor 1; 3.6.5.2", "protein_names_refseq": "ADP-ribosylation factor 1", "tax_id": 10116, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454)", "pathway": " (rno:64310); (R-RNO-1660499); (R-RNO-1660514); (R-RNO-199992); (R-RNO-2132295); (R-RNO-432720); (R-RNO-432722); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811438); (R-RNO-9845576)", "pathway_count": 11, "publication_count": 7, "publication_id_list": "10022920;10623590;10747863;23889934;7552752;7890632;8813705", "class_list": "", "function": "Arf1 is a critical regulator of actin dynamics and synaptic function via modulation of PICK1., [RefSeq, PubMed]; Small GTPase involved in protein trafficking between different compartments (By similarity). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (PubMed:23889934). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10947;P32889", "ec_number_list": "3.6.5.2;3.6.1.1;3.6.5.-;3.1.3.1;3.6.5.3;5.3.4.1;2.3.2.27;3.1.3.86;3.1.3.56;3.1.3.36;2.3.1.-;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.1;2.7.1.67;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4;3.4.17.22;3.1.22.1;3.4.18.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005778 peroxisomal membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0006886 intracellular protein transport;GO:0007015 actin filament organization;GO:0060292 long-term synaptic depression;GO:0097061 dendritic spine organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P84079-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84082-1", "uniprot_id": "ARF2_RAT", "mass": 20746.0, "length": 181, "protein_name": "ADP-ribosylation factor 2", "gene_name": "Arf2", "organism": "Rat", "refseq_name": "ADP-ribosylation factor 2", "refseq_ac": "NP_077064", "gene_names_uniprotkb": "Arf2", "gene_names_refseq": "Arf2", "protein_names_uniprotkb": "ADP-ribosylation factor 2", "protein_names_refseq": "ADP-ribosylation factor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:79119)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8813705", "class_list": "", "function": "GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10947;P16500;Q4KM00", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P84082-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84083-1", "uniprot_id": "ARF5_RAT", "mass": 20530.0, "length": 180, "protein_name": "ADP-ribosylation factor 5", "gene_name": "Arf5", "organism": "Rat", "refseq_name": "ADP-ribosylation factor 5", "refseq_ac": "NP_077063", "gene_names_uniprotkb": "Arf5", "gene_names_refseq": "Arf5", "protein_names_uniprotkb": "ADP-ribosylation factor 5", "protein_names_refseq": "ADP-ribosylation factor 5", "tax_id": 10116, "disease": "", "pathway": " (rno:79117); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10022920;20921225;8813705", "class_list": "", "function": "A functional role for CAPS1 in regulating DCV trafficking in the trans-Golgi network; this activity occurs via protein-protein interaction with ARF4/ARF5 in a GDP-dependent manner., [RefSeq, PubMed]; GTP-binding protein involved in protein trafficking. Contributes to vesicle budding and uncoating at the Golgi apparatus. Regulates mTORC1 activity at the plasma membrane by promoting its recruitment to membrane ruffles, facilitating activation via the PI3K/Akt signaling pathway. Acts as an early responder to lysosomal damage and participates in lysosomal quality control pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P26437", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P84083-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97553-1", "uniprot_id": "EFNA1_RAT", "mass": 23763.0, "length": 205, "protein_name": "Ephrin-A1", "gene_name": "Efna1", "organism": "Rat", "refseq_name": "ephrin-A1 precursor", "refseq_ac": "NP_446051", "gene_names_uniprotkb": "Efna1; Epgl1; Lerk1", "gene_names_refseq": "B61; Efna1", "protein_names_uniprotkb": "Ephrin-A1; EPH-related receptor tyrosine kinase ligand 1; Immediate early response protein B61; LERK-1", "protein_names_refseq": "EPH-related receptor tyrosine kinase ligand 1; LERK-1; ephrin-A1 precursor; immediate early response protein B61", "tax_id": 10116, "disease": "", "pathway": " (rno:94268); (R-RNO-2682334); (R-RNO-3928663); (R-RNO-3928665)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "12077243;12615978;21603973;25677907;29350423;7675446", "class_list": "", "function": "Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Involved in angiogenesis, regulating vascular endothelial cell differentiation and migration through activation of EPHA2. Acts as a ligand for EPHA3, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development. May also contribute to dendritic spine morphogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that ephrinA1 ligands play a role in the pathophysiology of spinal cord injury., [RefSeq, PubMed]; Ephrin A1 is expressed in adult thymic connective tissue trabeculae, most cortical epithelial cells, and both cortical and medullary thymocytes., [RefSeq, PubMed]; In myelinating co-cultures and in zebrafish, we find that the number of mature oligodendrocytes does not change as result of manipulating signaling through the ephrinA1-EphA4 system. However, in both systems, inhibition of EphA4 signaling leads to a higher number of myelin sheaths formed by each oligodendrocyte. In isolated oligodendrocyte cultures, activation of EphA4 reduced process extension., [RefSeq, PubMed]; The Rac/PAK pathwayis involved in ephrinA1-mediated inhibition of cell spreading. In this way, ephrinA1, alone or in synergy with S1P, can participate in blood vessel destabilization, a prerequisite for angiogenesis., [RefSeq, PubMed]; The findings that ephrinA1-PE38/GM-CSF had a high efficacy in the activation of the dendritic cells would facilitate the development of in vivo dendritic-cell vaccines for the treatment of gliomas in rats, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NS29", "ec_number_list": "", "go_molecular_function": "GO:0046875 ephrin receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0098552 side of membrane", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0043410 positive regulation of MAPK cascade;GO:0043535 regulation of blood vessel endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97553-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97554-1", "uniprot_id": "DNJB9_RAT", "mass": 25717.0, "length": 222, "protein_name": "DnaJ homolog subfamily B member 9", "gene_name": "Dnajb9", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily B member 9 precursor", "refseq_ac": "NP_036831", "gene_names_uniprotkb": "Dnajb9; Mdg1", "gene_names_refseq": "Dnajb9; ERdj4; Mdg1", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 9; ER-resident protein ERdj4; ERdj4; Endoplasmic reticulum DNA J domain-containing protein 4; Mdg-1; Microvascular endothelial differentiation gene 1 protein", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 9; ER-resident protein ERdj4; dnaJ homolog subfamily B member 9 precursor; dnaJ homolog, subfamily b, member 9; endoplasmic reticulum DNA J domain-containing protein 4; mdg-1; microvascular endothelial differentiation gene 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:24908)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11525638;29393594", "class_list": "", "function": "Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (By similarity). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0030544 Hsp70 protein binding;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0030183 B cell differentiation;GO:0036503 ERAD pathway;GO:0034976 response to endoplasmic reticulum stress;GO:0006986 response to unfolded protein;GO:1903895 negative regulation of IRE1-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97583-1", "uniprot_id": "BKRB1_RAT", "mass": 38378.0, "length": 337, "protein_name": "B1 bradykinin receptor", "gene_name": "Bdkrb1", "organism": "Rat", "refseq_name": "B1 bradykinin receptor", "refseq_ac": "NP_110478", "gene_names_uniprotkb": "Bdkrb1; B1bkr; Bkr", "gene_names_refseq": "BKR; Bdkrb1; Bdkrb; b1bkr", "protein_names_uniprotkb": "B1 bradykinin receptor; B1R; BK-1 receptor; KB1; Kinin B1 receptor", "protein_names_refseq": "B1 bradykinin receptor; B1R; BK-1 receptor; KB1; bradykinin B1 receptor; bradykinin receptor, beta 1; kinin B1 receptor", "tax_id": 10116, "disease": "overactive bladder syndrome (Disease Ontology:DOID:0070355); pleurisy (Disease Ontology:DOID:10247); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); epilepsy (Disease Ontology:DOID:1826); glomerulonephritis (Disease Ontology:DOID:2921); pulmonary fibrosis (Disease Ontology:DOID:3770); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:81509); (R-RNO-375276); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10422787;29285756;30580020;31309451;33687297;34828323;9804950", "class_list": "", "function": "Findings show that B1R negatively regulates collagen synthesis in cardiac myofibroblasts involving differents signaling pathways., [RefSeq, PubMed]; High bradykinin receptor B1 expression is associated with spinal cord ischemia-reperfusion injury., [RefSeq, PubMed]; Myocardial angiogenesis induced by exercise training involves a regulatory mechanism mediated by kinin receptors., [RefSeq, PubMed]; Our results support the detrimental role of B1 receptors on endothelial and glial cells in acute and advanced phases of diabetes retinopathy, [RefSeq, PubMed]; The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35782;Q9R250", "ec_number_list": "", "go_molecular_function": "GO:0042277 peptide binding;GO:0004947 bradykinin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0016477 cell migration;GO:0032496 response to lipopolysaccharide;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97583-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97612-1", "uniprot_id": "FAAH1_RAT", "mass": 63357.0, "length": 579, "protein_name": "Fatty-acid amide hydrolase 1", "gene_name": "Faah", "organism": "Rat", "refseq_name": "fatty-acid amide hydrolase 1", "refseq_ac": "NP_001356055", "gene_names_uniprotkb": "Faah; Faah1", "gene_names_refseq": "Faah", "protein_names_uniprotkb": "Fatty-acid amide hydrolase 1; 3.1.1.-; 3.5.1.99; Anandamide amidase; Anandamide amidohydrolase 1; Fatty acid ester hydrolase; Oleamide hydrolase 1", "protein_names_refseq": "anandamide amidase; anandamide amidohydrolase 1; fatty acid ester hydrolase; fatty-acid amide hydrolase 1; oleamide hydrolase 1", "tax_id": 10116, "disease": "Parkinson's disease 1 (Disease Ontology:DOID:0060367); alcohol use disorder (Disease Ontology:DOID:1574); substance-related disorder (Disease Ontology:DOID:303); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:100911581); (R-RNO-2142753)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10526230;11128635;12459591;12734197;15533037;17649977;18753625;32682844;33359656;36154489;38368587;8900284;9122178;9299394;9452020;9790682", "class_list": "", "function": "2.8 angstrom crystal structure; structure of FAAH complexed with an arachidonyl inhibitor reveals how a set of structural alterations allows this enzyme to integrate into cell membranes and establish direct access to the bilayer from its active site, [RefSeq, PubMed]; Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:10526230, PubMed:11128635, PubMed:15533037, PubMed:17649977, PubMed:9122178, PubMed:9299394, PubMed:9790682). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:11128635, PubMed:9122178). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:10526230, PubMed:15533037, PubMed:17649977). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats., [RefSeq, PubMed]; Fatty acid amide hydrolase activity in the dorsal periaqueductal gray attenuates neuropathic pain and associated dysautonomia., [RefSeq, PubMed]; Inhibition of Fatty Acid Amide Hydrolase (FAAH) During Adolescence and Exposure to Early Life Stress may Exacerbate Depression-like Behaviors in Male and Female Rats., [RefSeq, PubMed]; The impact of sleep deprivation on sexual behaviors and FAAH expression in the prefrontal cortex of male rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKA3", "ec_number_list": "3.1.1.23;3.1.1.79;3.1.1.6;3.5.1.114;3.5.1.14;3.3.2.9;3.5.1.99;3.1.1.-;3.1.-.-", "go_molecular_function": "GO:0017064 fatty acid amide hydrolase activity;GO:0005543 phospholipid binding;GO:0016788 hydrolase activity, acting on ester bonds;GO:0042802 identical protein binding;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0098794 postsynapse;GO:0031090 organelle membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0009062 fatty acid catabolic process;GO:0045471 response to ethanol;GO:0045907 positive regulation of vasoconstriction;GO:0052651 monoacylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P97612-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97675-1", "uniprot_id": "ENPP3_RAT", "mass": 99072.0, "length": 875, "protein_name": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 3", "gene_name": "Enpp3", "organism": "Rat", "refseq_name": "ectonucleotide pyrophosphatase/phosphodiesterase family member 3", "refseq_ac": "NP_062243", "gene_names_uniprotkb": "Enpp3; Npp3; Pdnp3", "gene_names_refseq": "B10; E-NPP 3; Enpp3; Npp3; PD-Ibeta; RB13-6", "protein_names_uniprotkb": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; 3.1.4.1; 3.6.1.-; 3.6.1.9; Alkaline phosphodiesterase I; B10; Dinucleoside polyphosphatase; E-NPP 3; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; PD-Ibeta; Phosphodiesterase I beta; Phosphodiesterase I/nucleotide pyrophosphatase 3; RB13-6 antigen", "protein_names_refseq": "NPPase; RB13-6 antigen; alkaline phosphodiesterase I; alkaline phosphodiesterase; dinucleoside polyphosphatase; ectonucleotide pyrophosphatase/phosphodiesterase family member 3-like; ectonucleotide pyrophosphatase/phosphodiesterase family member 3; nucleotide diphosphatase; phosphodiesterase I beta; phosphodiesterase I/nucleotide pyrophosphatase 3", "tax_id": 10116, "disease": "", "pathway": " (rno:54410)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11069764;21454685;22086174;22673903;30387774;7730366;9096610", "class_list": "", "function": "Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 and 3 are expressed on podocytes, but changes in expression of these enzymes are most likely not involved in etiology of insulin resistance in podocytes., [RefSeq, PubMed]; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate immune response (By similarity). 2',3'-cGAMP appears to be further processed to GMP, AMP and inorganic phosphate (By similarity). Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation (By similarity). Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro (PubMed:9096610)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; NPP3 crystall structure at 2.77 A resolution reveals that the active-site zinc ions are missing and a large part of the active site and the surrounding residues are flexible., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "P70641;P97676;Q4V8L6;Q63490", "ec_number_list": "3.6.1.9;3.6.1.68;3.6.1.76;3.1.3.5;2.7.1.77;3.1.3.99;3.6.1.29;3.1.3.1;3.9.1.1;3.1.3.91;3.1.3.89;3.1.3.35;3.6.1.-;3.1.4.1;3.6.1.59;3.6.1.52;3.6.1.62;3.6.1.10;3.6.1.61;3.6.1.17;3.9.1.-;2.7.7.51;3.6.2.1", "go_molecular_function": "GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0036219 GTP diphosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0006796 phosphate-containing compound metabolic process;GO:0055062 phosphate ion homeostasis;GO:0046034 ATP metabolic process;GO:0009143 nucleoside triphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97675-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97682-1", "uniprot_id": "ESM1_RAT", "mass": 20075.0, "length": 184, "protein_name": "Endothelial cell-specific molecule 1", "gene_name": "Esm1", "organism": "Rat", "refseq_name": "endothelial cell-specific molecule 1 precursor", "refseq_ac": "NP_072126", "gene_names_uniprotkb": "Esm1", "gene_names_refseq": "Esm1; Pg25", "protein_names_uniprotkb": "Endothelial cell-specific molecule 1; ESM-1; PG25", "protein_names_refseq": "ESM-1 secretory protein; endothelial cell-specific molecule 1 precursor; pineal specific PG25 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:64536)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23850961;9196290", "class_list": "", "function": "Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions (By similarity)., [UniProtKB]; Peripheral blood ESM-1 mRNA and ESM-1 protein expression in kidney grafts can reflect the severity of endothelial cell impairment, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005171 hepatocyte growth factor receptor binding;GO:0005178 integrin binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:1902204 positive regulation of hepatocyte growth factor receptor signaling pathway;GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0002040 sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97682-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P98193-1", "uniprot_id": "DMP1_RAT", "mass": 53058.0, "length": 489, "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "Dmp1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dmp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dentin matrix acidic phosphoprotein 1; AG1; DMP-1; Dentin matrix protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive hypophosphatemic rickets (Disease Ontology:DOID:0050949)", "pathway": " (R-RNO-3000178); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8509401", "class_list": "", "function": "May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050840 extracellular matrix binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0070173 regulation of enamel mineralization;GO:0030198 extracellular matrix organization;GO:0010811 positive regulation of cell-substrate adhesion;GO:0031214 biomineral tissue development;GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P98193-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02293-1", "uniprot_id": "FNTB_RAT", "mass": 48673.0, "length": 437, "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "Fntb", "organism": "Rat", "refseq_name": "protein farnesyltransferase subunit beta", "refseq_ac": "NP_742031", "gene_names_uniprotkb": "Fntb", "gene_names_refseq": "Fntb", "protein_names_uniprotkb": "Protein farnesyltransferase subunit beta; 2.5.1.58; CAAX farnesyltransferase subunit beta; FTase-beta; Ras proteins prenyltransferase subunit beta", "protein_names_refseq": "CAAX farnesyltransferase subunit beta; FTase-beta; farnesyltransferase beta subunit; farnesyltransferase, CAAX box, beta; protein farnesyltransferase subunit beta; ras proteins prenyltransferase subunit beta", "tax_id": 10116, "disease": "", "pathway": " (rno:64511); (R-RNO-2514859); (R-RNO-9648002); (R-RNO-9953170)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10673434;11687658;12374986;12667062;15451670;1855253;18844669;19219049;19246009;20056542;22963166;29282289;9065406;9609683;9657673;9843427", "class_list": "", "function": "Data suggest that substrate specificity of protein farnesyltransferase (subunits Fnta plus Fntb) is extensive; these results expand the scope of the potential prenylated proteome in this species. (Fnta = farnesyltransferase CAAX box alpha protein; Fntb = farnesyltransferase CAAX box beta protein), [RefSeq, PubMed]; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;2.5.1.58;2.5.1.59", "go_molecular_function": "GO:0004660 protein farnesyltransferase activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0010698 acetyltransferase activator activity;GO:0004311 geranylgeranyl diphosphate synthase activity", "go_cellular_component": "GO:0005965 protein farnesyltransferase complex;GO:0005875 microtubule associated complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0018343 protein farnesylation;GO:0045787 positive regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q02293-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02435-1", "uniprot_id": "BFSP1_RAT", "mass": 68038.0, "length": 617, "protein_name": "Filensin", "gene_name": "Bfsp1", "organism": "Rat", "refseq_name": "filensin", "refseq_ac": "NP_113743", "gene_names_uniprotkb": "Bfsp1", "gene_names_refseq": "115-kDa; Bfsp1; CP94; CP95; CP97", "protein_names_uniprotkb": "Filensin; Beaded filament structural protein 1; CP94; Lens fiber cell beaded-filament structural protein CP 94", "protein_names_refseq": "CP97 115-kDa; beaded filament structural protein 1, filensin; filensin; lens fiber cell beaded-filament structural protein CP 94", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 34 (Disease Ontology:DOID:0070064); cataract 33 (Disease Ontology:DOID:0110264)", "pathway": " (rno:25394)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1378722;18449355", "class_list": "", "function": "Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Involved in altering the calcium regulation of MIP water permeability (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The degradation of filensin and phakinin in normal and cataractous rat lenses, was examined. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0005882 intermediate filament", "go_biological_process": "GO:0045109 intermediate filament organization;GO:0048469 cell maturation;GO:0070307 lens fiber cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q02435-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04906-1", "uniprot_id": "BMP6_RAT", "mass": 56223.0, "length": 506, "protein_name": "Bone morphogenetic protein 6", "gene_name": "Bmp6", "organism": "Rat", "refseq_name": "bone morphogenetic protein 6 precursor", "refseq_ac": "NP_037239", "gene_names_uniprotkb": "Bmp6; Bmp-6; Vgr", "gene_names_refseq": "Bmp6; VGR", "protein_names_uniprotkb": "Bone morphogenetic protein 6; BMP-6; VG-1-related protein; VGR-1", "protein_names_refseq": "BMP-6; VG-1-related protein; VGR-1; bone morphogenetic protein 6 precursor", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); recessive dystrophic epidermolysis bullosa (Disease Ontology:DOID:0060642); nonsyndromic congenital nail disorder 8 (Disease Ontology:DOID:0080086); autosomal dominant dystrophic epidermolysis bullosa (Disease Ontology:DOID:0080224); pretibial dystrophic epidermolysis bullosa (Disease Ontology:DOID:0080988); transient bullous dermolysis of the newborn (Disease Ontology:DOID:0111345); epidermolysis bullosa with congenital localized absence of skin and deformity of nails (Disease Ontology:DOID:0111347); prostate cancer (Disease Ontology:DOID:10283); Marfan syndrome (Disease Ontology:DOID:14323); breast cancer (Disease Ontology:DOID:1612); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); epidermolysis bullosa dystrophica (Disease Ontology:DOID:4959); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25644)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1453478;28256809;31121597;32448307;36845161", "class_list": "", "function": "BMP-6 promotes type 2 immune response during enhancement of rat mandibular bone defect healing. Publication Status: Online-Only, [RefSeq, PubMed]; Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (By similarity). Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV (By similarity). Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3 (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Impairment of maturation of BMP-6 (35 kDa) correlates with delayed fracture healing in experimental diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; Junin virus infection of osteoblasts upregulated the expression of BMP6, [RefSeq, PubMed]; Study revealed that only BMP-6 was able to induce bone formation at the used dose and that the addition of IGF-1 contributed to an increase of the mineralization in the implants. Hence, the combination of BMP-6 with IGF-1 might be a better alternative than BMP-2 for orthopedic surgery or bone tissue engineering approaches., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q811S4", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0031982 vesicle;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007507 heart development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04906-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07303-1", "uniprot_id": "EPOR_RAT", "mass": 55500.0, "length": 507, "protein_name": "Erythropoietin receptor", "gene_name": "Epor", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Epor", "gene_names_refseq": "", "protein_names_uniprotkb": "Erythropoietin receptor; EPO-R", "protein_names_refseq": "", "tax_id": 10116, "disease": "familial erythrocytosis 1 (Disease Ontology:DOID:0060652); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); retinopathy of prematurity (Disease Ontology:DOID:13025); hepatic encephalopathy (Disease Ontology:DOID:13413); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); high grade glioma (Disease Ontology:DOID:3070); cholangiocarcinoma (Disease Ontology:DOID:4947); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); polycythemia (Disease Ontology:DOID:8432); polycythemia vera (Disease Ontology:DOID:8997); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (R-RNO-9006335); (R-RNO-9027276); (R-RNO-9027284)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "7684373;9029168", "class_list": "", "function": "Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling., [UniProtKB, UniProtKB]; Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (By similarity). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity). In some cell types, can also activate STAT1 and STAT3 (By similarity). May also activate the LYN tyrosine kinase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004900 erythropoietin receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q07303-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07803-1", "uniprot_id": "EFGM_RAT", "mass": 83457.0, "length": 751, "protein_name": "Elongation factor G, mitochondrial", "gene_name": "Gfm1", "organism": "Rat", "refseq_name": "elongation factor G, mitochondrial", "refseq_ac": "NP_446077", "gene_names_uniprotkb": "Gfm1; EFG1; Efg1; Efg; GFM1; Gfm", "gene_names_refseq": "EF-G; Efg; Gfm1; Gfm", "protein_names_uniprotkb": "Elongation factor G, mitochondrial; 3.6.5.-; EF-Gmt; Elongation factor G 1, mitochondrial; Elongation factor G1; mEF-G 1", "protein_names_refseq": "EF-Gmt; elongation factor G 1, mitochondrial; elongation factor G, mitochondrial; elongation factor G1; mEF-G 1; mitochondrial elongation factor G", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 1 (Disease Ontology:DOID:0111474)", "pathway": " (rno:114017); (R-RNO-5389840)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8332461", "class_list": "", "function": "Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U347", "ec_number_list": "3.6.5.2;3.1.1.29;3.6.1.1;3.6.5.-;3.6.5.3;2.3.2.27;2.7.11.1;3.6.5.5;3.6.1.5;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0070125 mitochondrial translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q07803-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07936-1", "uniprot_id": "ANXA2_RAT", "mass": 38678.0, "length": 339, "protein_name": "Annexin A2", "gene_name": "Anxa2", "organism": "Rat", "refseq_name": "annexin A2", "refseq_ac": "NP_063970", "gene_names_uniprotkb": "Anxa2; Anx2", "gene_names_refseq": "ANX2; Anxa2", "protein_names_uniprotkb": "Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; PAP-IV; Placental anticoagulant protein IV; Protein I; p36", "protein_names_refseq": "PAP-IV; annexin A2; annexin-2; calpactin I heavy chain; calpactin-1 heavy chain; chromobindin-8; lipocortin II; p36; placental anticoagulant protein IV; protein I", "tax_id": 10116, "disease": "osteonecrosis (Disease Ontology:DOID:10159); paranasal sinus benign neoplasm (Disease Ontology:DOID:1350); hypothyroidism (Disease Ontology:DOID:1459); invasive ductal carcinoma (Disease Ontology:DOID:3008); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperthyroidism (Disease Ontology:DOID:7998)", "pathway": " (rno:56611); (R-RNO-6798695); (R-RNO-75205); (R-RNO-9860927)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "1618851;18683930;21454685;22673903;28729092;30332317;34494994;34502162;37249328;8092993;8389036", "class_list": "", "function": "ANGII increases Annexin-A2 nucleic acid-binding activity and elevates protein levels of the NFAT5 transcription factor in kidneys of hypertensive rats., [RefSeq, PubMed]; Annexin A2 degradation contributes to dopaminergic cell apoptosis via regulating p53 in neurodegenerative conditions., [RefSeq, PubMed]; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Cav-1 participates upstream of ANXA2 in the activation of ERK1/2 and NF-kappaB., [RefSeq, PubMed]; METTL3-mediated ANXA2 inhibition confers neuroprotection in ischemic stroke: Evidence from in vivo and in vitro studies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005811 lipid droplet", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0007155 cell adhesion;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q07936-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q10473-1", "uniprot_id": "GALT1_RAT", "mass": 64229.0, "length": 559, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 1", "gene_name": "Galnt1", "organism": "Rat", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 1", "refseq_ac": "NP_077349", "gene_names_uniprotkb": "Galnt1", "gene_names_refseq": "Galnt1", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 1; 2.4.1.41; GalNAc-T1; Polypeptide GalNAc transferase 1; Protein-UDP acetylgalactosaminyltransferase 1; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1; pp-GaNTase 1", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1); galNAc-T1; polypeptide GalNAc transferase 1; polypeptide GalNAc transferase T1; polypeptide N-acetylgalactosaminyltransferase 1; pp-GaNTase 1; protein-UDP acetylgalactosaminyltransferase 1", "tax_id": 10116, "disease": "heart valve disease (Disease Ontology:DOID:4079)", "pathway": " (rno:79214); (R-RNO-6811436); (R-RNO-913709)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12199709;12364335;12419318;8748168", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:12199709, PubMed:12364335, PubMed:12419318). Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The GalNAc-T1 lectin domain plays a critical role in enzymatic activity, and GalNAc-T1 has two activities distinguished by their sensitivities to inhibition with free GalNAc, [RefSeq, PubMed]; The lectin domain of GalNAc-T1 has at least two functional repeats, allowing the possibility of multivalent interactions with GalNAc residues on the acceptor polypeptide during glycosylation, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 23, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;2.4.1.-;2.4.1.41;3.6.5.-", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0032580 Golgi cisterna membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.5, "record_id": "Q10473-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q10980-1", "uniprot_id": "FUT1_RAT", "mass": 42417.0, "length": 376, "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 1", "gene_name": "Fut1", "organism": "Rat", "refseq_name": "galactoside alpha-(1,2)-fucosyltransferase 1", "refseq_ac": "NP_112515", "gene_names_uniprotkb": "Fut1; Fta", "gene_names_refseq": "FTA; Fut1; Futa", "protein_names_uniprotkb": "Galactoside alpha-(1,2)-fucosyltransferase 1; 2.4.1.344; 2.4.1.69; Alpha 1,2-fucosyltransferase A; Alpha(1,2)FT 1; Fucosyltransferase 1; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1; Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1", "protein_names_refseq": "GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; alpha 1,2-fucosyltransferase A; alpha 12-fucosyltransferase; alpha(1,2)FT 1; alpha12-fucosyltransferase a; fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase); galactoside 2-alpha-L-fucosyltransferase 1; galactoside alpha-(1,2)-fucosyltransferase 1; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); essential hypertension (Disease Ontology:DOID:10825); cholestasis (Disease Ontology:DOID:13580); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); liver cirrhosis (Disease Ontology:DOID:5082); oral submucous fibrosis (Disease Ontology:DOID:5773); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:81919); (R-RNO-9033807); (R-RNO-9840309)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11179967;8010942", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q549F8", "ec_number_list": "2.4.1.-;2.4.1.344;2.4.1.69", "go_molecular_function": "GO:0008417 fucosyltransferase activity;GO:0031127 alpha-(1,2)-fucosyltransferase activity;GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0006664 glycolipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0010595 positive regulation of endothelial cell migration;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 1540, "hit_score": 0.3, "record_id": "Q10980-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2HWF0-1", "uniprot_id": "FBP1L_RAT", "mass": 69974.0, "length": 605, "protein_name": "Formin-binding protein 1-like", "gene_name": "Fnbp1l", "organism": "Rat", "refseq_name": "formin-binding protein 1-like", "refseq_ac": "NP_001034698", "gene_names_uniprotkb": "Fnbp1l; Toca1", "gene_names_refseq": "Fnbp1l; RGD1305386; Toca-1", "protein_names_uniprotkb": "Formin-binding protein 1-like; Toca-1; Transducer of Cdc42-dependent actin assembly protein 1", "protein_names_refseq": "Cdc42 effector; formin-binding protein 1-like; transducer of Cdc42-dependent actin assembly protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:310839); (R-RNO-8856828)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16885158;18923421;22673903;25547174", "class_list": "", "function": "A vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP, [RefSeq, PubMed]; Loss of p53 tumor suppressor function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease. Publication Status: Online-Only, [RefSeq, PubMed]; N-WASP-WIP complex-mediated actin polymerization is activated by phosphatidylserine-containing membranes depending on membrane curvature in the presence of Toca-1 or FBP17 and in the absence of Cdc42 and phosphatidylinositol (4,5)-bisphosphate. Erratum:[EMBO J. 2008 Dec 17;27(24):3332. Takano, Kazunari [corrected to Takano, Kazunori]], [RefSeq, PubMed]; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity). May negatively regulate neurite extension and axon branching in developing neurons., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2HWE9", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0010324 membrane invagination;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q2HWF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2IBD4-1", "uniprot_id": "CTTB2_RAT", "mass": 178768.0, "length": 1649, "protein_name": "Cortactin-binding protein 2", "gene_name": "Cttnbp2", "organism": "Rat", "refseq_name": "cortactin-binding protein 2", "refseq_ac": "NP_001107873", "gene_names_uniprotkb": "Cttnbp2", "gene_names_refseq": "Cbp90; Cortbp2; Cttnbp2", "protein_names_uniprotkb": "Cortactin-binding protein 2; CortBP2", "protein_names_refseq": "brain specific cortactin-binding protein CBP90; cortactin-binding protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:282587)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12917688;22262902;22673903;23015759;24928895;33168105;9813110", "class_list": "", "function": "Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]; Cttnbp2 increases microtubule stability and regulates dendritic arborization., [RefSeq, PubMed]; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance (PubMed:22262902). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons (PubMed:23015759)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; This sst=udy demonistrated that Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88864", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005938 cell cortex;GO:0043197 dendritic spine;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0050807 regulation of synapse organization;GO:1905274 regulation of modification of postsynaptic actin cytoskeleton", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q2IBD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2KN99-1", "uniprot_id": "CYTSA_RAT", "mass": 124338.0, "length": 1118, "protein_name": "Cytospin-A", "gene_name": "Specc1l", "organism": "Rat", "refseq_name": "cytospin-A", "refseq_ac": "NP_001034544", "gene_names_uniprotkb": "Specc1l; Cytsa", "gene_names_refseq": "Cytsa; RGD1309570; Specc1l", "protein_names_uniprotkb": "Cytospin-A; SPECC1-like protein; Sperm antigen with calponin homology and coiled-coil domains 1-like", "protein_names_refseq": "28S ribosomal protein S7, mitochondrial-like; SPECC1-like protein; cytospin-A", "tax_id": 10116, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); Teebi hypertelorism syndrome 1 (Disease Ontology:DOID:0080698); oblique facial clefting 1 (Disease Ontology:DOID:0111706); cleft palate (Disease Ontology:DOID:674)", "pathway": " (rno:361828)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005911 cell-cell junction;GO:0015629 actin cytoskeleton;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0051301 cell division;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KN99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2LAM0-1", "uniprot_id": "FA2H_RAT", "mass": 42673.0, "length": 372, "protein_name": "Fatty acid 2-hydroxylase", "gene_name": "Fa2h", "organism": "Rat", "refseq_name": "fatty acid 2-hydroxylase", "refseq_ac": "NP_001129055", "gene_names_uniprotkb": "Fa2h; Faah", "gene_names_refseq": "Fa2h; RGD1310347; Wdr59", "protein_names_uniprotkb": "Fatty acid 2-hydroxylase; 1.14.18.-; Fatty acid alpha-hydroxylase", "protein_names_refseq": "WD repeat domain 59; fatty acid 2-hydroxylase; fatty acid alpha-hydroxylase", "tax_id": 10116, "disease": "hereditary spastic paraplegia 35 (Disease Ontology:DOID:0110786)", "pathway": " (rno:307855); (R-RNO-1660661)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16998236;17901466", "class_list": "", "function": "Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (Probable). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (By similarity). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (PubMed:17901466). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (By similarity). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; These observations indicate that FA2H is a myelination-associated gene. FA2H-dependent fatty acid 2-hydroxylation is required for the formation of 2-hydroxy galactolipids in peripheral nerve myelin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.18.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0080132 fatty acid 2-hydroxylase activity;GO:0120520 free fatty acid 2-hydroxylase activity;GO:0120521 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0042127 regulation of cell population proliferation;GO:0046513 ceramide biosynthetic process;GO:0061436 establishment of skin barrier;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2LAM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q32PX2-1", "uniprot_id": "AIMP2_RAT", "mass": 35443.0, "length": 320, "protein_name": "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2", "gene_name": "Aimp2", "organism": "Rat", "refseq_name": "aminoacyl tRNA synthase complex-interacting multifunctional protein 2", "refseq_ac": "NP_001032425", "gene_names_uniprotkb": "Aimp2; Jtv1", "gene_names_refseq": "Aimp2; Jtv1", "protein_names_uniprotkb": "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Multisynthase complex auxiliary component p38; Protein JTV-1", "protein_names_refseq": "JTV1; aminoacyl tRNA synthase complex-interacting multifunctional protein 2; multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38; protein JTV-1; rCG42778-like", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy 17 (Disease Ontology:DOID:0070404)", "pathway": " (rno:288480); (R-RNO-9856649)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0031398 positive regulation of protein ubiquitination;GO:0006412 translation;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32PX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q32PX9-1", "uniprot_id": "AFG1L_RAT", "mass": 54503.0, "length": 480, "protein_name": "AFG1-like ATPase", "gene_name": "AABR07045431.1; Afg1l", "organism": "Rat", "refseq_name": "AFG1-like ATPase", "refseq_ac": "NP_001032745", "gene_names_uniprotkb": "AABR07045431.1; Afg1l; AABR07045431.1; Afg1l; Lace1", "gene_names_refseq": "Afg1l; Lace1", "protein_names_uniprotkb": "AFG1-like ATPase; 3.6.-.-; Lactation elevated protein 1", "protein_names_refseq": "AFG1-like ATPase; lactation elevated 1; lactation elevated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:502479)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0035694 mitochondrial protein catabolic process;GO:0141164 mitochondrial protein quality control", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32PX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q32Q86-1", "uniprot_id": "CRY1_RAT", "mass": 66230.0, "length": 588, "protein_name": "Cryptochrome-1", "gene_name": "Cry1", "organism": "Rat", "refseq_name": "cryptochrome-1", "refseq_ac": "NP_942045", "gene_names_uniprotkb": "Cry1", "gene_names_refseq": "Cry1", "protein_names_uniprotkb": "Cryptochrome-1", "protein_names_refseq": "cryptochrome 1 (photolyase-like); cryptochrome circadian clock 1; cryptochrome-1", "tax_id": 10116, "disease": "delayed sleep phase syndrome (Disease Ontology:DOID:0111141); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:299691)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15529004;16790549;29894471;36376275", "class_list": "", "function": "Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1. Publication Status: Online-Only, [RefSeq, PubMed]; The model efficiently described the synchronous rhythmicity of core-clock genes and further predicted that their phases are mainly regulated by Per2 and Cry1 transcriptional delays and Rev-Erba and Cry1 degradation rates. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-BMAL1 independently of PER proteins and is found at CLOCK-BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1, ATF4, MTA1, KLF10 and NAMPT. May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Inhibits hepatic gluconeogenesis by decreasing nuclear FOXO1 levels that down-regulates gluconeogenic gene expression. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4 (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Plays an essential role in the generation of circadian rhythms in the retina (By similarity). Represses the transcriptional activity of NR1I2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q717B5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0019901 protein kinase binding;GO:0071949 FAD binding;GO:0042826 histone deacetylase binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:2000850 negative regulation of glucocorticoid secretion;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q32Q86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q32Q90-1", "uniprot_id": "COA8_RAT", "mass": 22769.0, "length": 193, "protein_name": "Cytochrome c oxidase assembly factor 8", "gene_name": "Coa8", "organism": "Rat", "refseq_name": "cytochrome c oxidase assembly factor 8", "refseq_ac": "NP_001032858", "gene_names_uniprotkb": "Coa8; Apop1; Apopt1", "gene_names_refseq": "APOP-1; Apop1; Apopt1; Coa8; RGD1304719", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor 8; APOP-1; Apoptogenic protein 1, mitochondrial; COA8", "protein_names_refseq": "UPF0671 protein C14orf153 homolog; apoptogenic 1, mitochondrial; apoptogenic protein 1, mitochondrial; cytochrome c oxidase assembly factor 8", "tax_id": 10116, "disease": "mitochondrial complex IV deficiency nuclear type 17 (Disease Ontology:DOID:0070502)", "pathway": " (rno:299341)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0099617 matrix side of mitochondrial inner membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0000302 response to reactive oxygen species;GO:0097193 intrinsic apoptotic signaling pathway;GO:1904960 positive regulation of cytochrome-c oxidase activity;GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32Q90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3B756-1", "uniprot_id": "FUZZY_RAT", "mass": 45407.0, "length": 415, "protein_name": "Protein fuzzy homolog", "gene_name": "Fuz", "organism": "Rat", "refseq_name": "protein fuzzy homolog isoform 2", "refseq_ac": "NP_001032735", "gene_names_uniprotkb": "Fuz", "gene_names_refseq": "Fuz; RGD1310608", "protein_names_uniprotkb": "Protein fuzzy homolog", "protein_names_refseq": "protein fuzzy homolog isoform 2; protein fuzzy homolog", "tax_id": 10116, "disease": "ciliopathy (Disease Ontology:DOID:0060340); neural tube defect (Disease Ontology:DOID:0080074)", "pathway": " (rno:308577); (R-RNO-5610787)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable planar cell polarity effector involved in cilium biogenesis. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate protein and membrane transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary cilia. Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0090301 negative regulation of neural crest formation;GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation;GO:0021513 spinal cord dorsal/ventral patterning;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B756-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3B8R1-1", "uniprot_id": "EMARD_RAT", "mass": 76562.0, "length": 678, "protein_name": "Endoplasmic reticulum membrane-associated RNA degradation protein", "gene_name": "Ermard", "organism": "Rat", "refseq_name": "endoplasmic reticulum membrane-associated RNA degradation protein", "refseq_ac": "NP_001406549", "gene_names_uniprotkb": "Ermard", "gene_names_refseq": "Ermard; RGD1309374; RGD1562376", "protein_names_uniprotkb": "Endoplasmic reticulum membrane-associated RNA degradation protein; ER membrane-associated RNA degradation protein", "protein_names_refseq": "endoplasmic reticulum membrane-associated RNA degradation protein", "tax_id": 10116, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454)", "pathway": " (rno:361485)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24056535", "class_list": "", "function": "May play a role in neuronal migration during embryonic development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZU62", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3B8R1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3LRZ1-1", "uniprot_id": "CRTC2_RAT", "mass": 73146.0, "length": 691, "protein_name": "CREB-regulated transcription coactivator 2", "gene_name": "Crtc2", "organism": "Rat", "refseq_name": "CREB-regulated transcription coactivator 2", "refseq_ac": "NP_001029067", "gene_names_uniprotkb": "Crtc2; Torc2", "gene_names_refseq": "Crtc2; RGD1308903; Torc2", "protein_names_uniprotkb": "CREB-regulated transcription coactivator 2; TORC-2; Transducer of CREB protein 2; Transducer of regulated cAMP response element-binding protein 2", "protein_names_refseq": "CREB-regulated transcription coactivator 2; TORC-2; transducer of CREB protein 2; transducer of regulated cAMP response element-binding protein 2", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:310615)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18086876;22673903;24949720;25080490;26167077;26210066;26508620", "class_list": "", "function": "Berberine inhibited hepatic gluconeogenesis via the regulation of the LKB1-AMPK-TORC2 signaling pathway., [RefSeq, PubMed]; CRTC2 and Nedd4 ligase involvement in FSH and TGFbeta1 upregulation of connexin43 gap junction, [RefSeq, PubMed]; Gastric inhibitory polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by CREB and TORC2., [RefSeq, PubMed]; Results indicate that overexpressing SIK1 can phosphorylate CRTC1 and CRTC2 in the norepinephrine (NE)-stimulated pinealocytes. Howeve, the endogenous SIK1 does not appear to be the main regulator of their phosphorylation and intracellular localization., [RefSeq, PubMed]; Suggest that CRTC2 participates in CREB-dependent photic entrainment of suprachiasmatic nucleus function., [RefSeq, PubMed]; These data suggest mTORC2 phosphorylation of Akt is a key mediator of H2S-induced cardioprotection in I/R. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008140 cAMP response element binding protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051289 protein homotetramerization;GO:0071320 cellular response to cAMP;GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3LRZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q400C7-1", "uniprot_id": "AMZ2_RAT", "mass": 41379.0, "length": 359, "protein_name": "Archaemetzincin-2", "gene_name": "Amz2", "organism": "Rat", "refseq_name": "archaemetzincin-2", "refseq_ac": "NP_001014143", "gene_names_uniprotkb": "Amz2", "gene_names_refseq": "Amz2; RGD1304846", "protein_names_uniprotkb": "Archaemetzincin-2; 3.4.-.-; Archeobacterial metalloproteinase-like protein 2", "protein_names_refseq": "archaemetzincin-2; archeobacterial metalloproteinase-like 2; archeobacterial metalloproteinase-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:360650)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15972818;38843836", "class_list": "", "function": "Probable zinc metalloprotease., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U2S2", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q400C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q496Z0-1", "uniprot_id": "ELP2_RAT", "mass": 91746.0, "length": 821, "protein_name": "Elongator complex protein 2", "gene_name": "Elp2", "organism": "Rat", "refseq_name": "elongator complex protein 2", "refseq_ac": "NP_001029317", "gene_names_uniprotkb": "Elp2; Statip1", "gene_names_refseq": "Elp2; Statip1", "protein_names_uniprotkb": "Elongator complex protein 2; ELP2; SHINC-2; STAT3-interacting protein 1; StIP1", "protein_names_refseq": "SHINC-2; STAT3-interacting protein 1; elongation protein 2 homolog; elongator complex protein 2; signal transducer and activator of transcription interacting protein 1; stIP1", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder 58 (Disease Ontology:DOID:0081220); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:307545)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q562B6", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0008023 transcription elongation factor complex;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q496Z0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q498D1-1", "uniprot_id": "FOXP1_RAT", "mass": 79586.0, "length": 711, "protein_name": "Forkhead box protein P1", "gene_name": "Foxp1", "organism": "Rat", "refseq_name": "forkhead box protein P1", "refseq_ac": "NP_001029303", "gene_names_uniprotkb": "Foxp1", "gene_names_refseq": "Foxp1", "protein_names_uniprotkb": "Forkhead box protein P1", "protein_names_refseq": "forkhead box protein P1", "tax_id": 10116, "disease": "specific developmental disorder (Disease Ontology:DOID:0060038); complex cortical dysplasia with other brain malformations (Disease Ontology:DOID:0090131); intellectual disability-severe speech delay-mild dysmorphism syndrome (Disease Ontology:DOID:0111331); trichostrongyloidiasis (Disease Ontology:DOID:1255); Huntington's disease (Disease Ontology:DOID:12858); congenital heart disease (Disease Ontology:DOID:1682); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); esophagus adenocarcinoma (Disease Ontology:DOID:4914); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); peritonitis (Disease Ontology:DOID:8283); Barrett's esophagus (Disease Ontology:DOID:9206); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (rno:297480)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22673903;30170733;30302539;33128129;38556338", "class_list": "", "function": "Both Pnoc and FoxP1 were expressed at high levels in the rostromedial tegmental nucleus and colocalized strongly with previously established RMTg markers. FoxP1 was particularly selective for RMTg neurons, as it was absent in most adjacent brain regions., [RefSeq, PubMed]; MiR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells., [RefSeq, PubMed]; MiR-522-3p Attenuates Cardiac Recovery by Targeting FOXP1 to Suppress Angiogenesis., [RefSeq, PubMed]; The results indicate that FOXP1 plays a crucial role in tendon-derived stem/progenitor cell aging., [RefSeq, PubMed]; Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:1904263 positive regulation of TORC1 signaling;GO:0030316 osteoclast differentiation;GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death;GO:0032651 regulation of interleukin-1 beta production", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q498D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q498S8-1", "uniprot_id": "FZD8_RAT", "mass": 73009.0, "length": 684, "protein_name": "Frizzled-8", "gene_name": "Fzd8", "organism": "Rat", "refseq_name": "frizzled-8 precursor", "refseq_ac": "NP_001037716", "gene_names_uniprotkb": "Fzd8", "gene_names_refseq": "Fzd8", "protein_names_uniprotkb": "Frizzled-8; Fz-8", "protein_names_refseq": "frizzled family receptor 8; frizzled-8 precursor; frizzled-8-like; frizzled-8; fz-8", "tax_id": 10116, "disease": "", "pathway": " (rno:364754); (R-RNO-4608870); (R-RNO-4641263)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "25619565;36047789", "class_list": "", "function": "Angiotensin-receptor blocker losartan alleviates atrial fibrillation in rats by downregulating frizzled 8 and inhibiting the activation of WNT-5A pathway., [RefSeq, PubMed]; MiR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts, [RefSeq, PubMed]; Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1 (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0031625 ubiquitin protein ligase binding;GO:0030165 PDZ domain binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:1990851 Wnt-Frizzled-LRP5/6 complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0016055 Wnt signaling pathway;GO:0060070 canonical Wnt signaling pathway;GO:0033077 T cell differentiation in thymus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q498S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q498T2-1", "uniprot_id": "CHTOP_RAT", "mass": 26517.0, "length": 248, "protein_name": "Chromatin target of PRMT1 protein", "gene_name": "Chtop", "organism": "Rat", "refseq_name": "chromatin target of PRMT1 protein isoform 4", "refseq_ac": "NP_001014197", "gene_names_uniprotkb": "Chtop; Fop", "gene_names_refseq": "Chtop; Fop; SRAG", "protein_names_uniprotkb": "Chromatin target of PRMT1 protein; Friend of PRMT1 protein; SRAG; Small arginine- and glycine-rich protein", "protein_names_refseq": "Friend of PRMT1 protein; chromatin target of PRMT1 protein isoform 4; chromatin target of PRMT1 protein; small arginine- and glycine-rich protein", "tax_id": 10116, "disease": "", "pathway": " (rno:361990); (R-RNO-159236)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66H75", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0000346 transcription export complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006406 mRNA export from nucleus;GO:0032781 positive regulation of ATP-dependent activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q498T2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499M5-1", "uniprot_id": "ANR16_RAT", "mass": 40560.0, "length": 370, "protein_name": "Ankyrin repeat domain-containing protein 16", "gene_name": "Ankrd16", "organism": "Rat", "refseq_name": "ankyrin repeat domain-containing protein 16", "refseq_ac": "NP_001028870", "gene_names_uniprotkb": "Ankrd16", "gene_names_refseq": "Ankrd16", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 16", "protein_names_refseq": "ankyrin repeat domain-containing protein 16", "tax_id": 10116, "disease": "", "pathway": " (rno:307102)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499M5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499N2-1", "uniprot_id": "AP5M1_RAT", "mass": 54439.0, "length": 490, "protein_name": "AP-5 complex subunit mu-1", "gene_name": "Ap5m1", "organism": "Rat", "refseq_name": "AP-5 complex subunit mu-1", "refseq_ac": "NP_001025207", "gene_names_uniprotkb": "Ap5m1; Mudeng", "gene_names_refseq": "Ap5m1; Mu5; Mudeng; RGD1308087", "protein_names_uniprotkb": "AP-5 complex subunit mu-1; Adaptor-related protein complex 5 subunit mu-1; Mu-2-related death-inducing protein; Mu5; MuD", "protein_names_refseq": "AP-5 complex subunit mu-1; MHD domain-containing death-inducing protein; MU-2/AP1M2 domain containing, death-inducing; adapter-related protein complex 5 mu subunit; adapter-related protein complex 5 subunit mu-1; adaptor-related protein complex 5, mu 1 subunit; mu-2-related death-inducing protein; muD", "tax_id": 10116, "disease": "", "pathway": " (rno:305861)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4FZR5-1", "uniprot_id": "ACD_RAT", "mass": 45591.0, "length": 417, "protein_name": "Adrenocortical dysplasia protein homolog", "gene_name": "Acd", "organism": "Rat", "refseq_name": "adrenocortical dysplasia protein homolog", "refseq_ac": "NP_001032270", "gene_names_uniprotkb": "Acd", "gene_names_refseq": "Acd", "protein_names_uniprotkb": "Adrenocortical dysplasia protein homolog", "protein_names_refseq": "adrenocortical dysplasia homolog; adrenocortical dysplasia protein homolog", "tax_id": 10116, "disease": "autosomal dominant dyskeratosis congenita 6 (Disease Ontology:DOID:0070023)", "pathway": " (rno:307798); (R-RNO-110330); (R-RNO-110331); (R-RNO-171319); (R-RNO-174411); (R-RNO-174414); (R-RNO-174417); (R-RNO-174430); (R-RNO-174437); (R-RNO-2559586)", "pathway_count": 10, "publication_count": 2, "publication_id_list": "22673903;35805162", "class_list": "", "function": "Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0044877 protein-containing complex binding;GO:0070182 DNA polymerase binding;GO:0010521 telomerase inhibitor activity", "go_cellular_component": "GO:0016604 nuclear body;GO:0000783 nuclear telomere cap complex;GO:0070187 shelterin complex;GO:0005697 telomerase holoenzyme complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0000723 telomere maintenance;GO:0001501 skeletal system development;GO:0001655 urogenital system development;GO:0016233 telomere capping", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4FZR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4FZU6-1", "uniprot_id": "ANXA8_RAT", "mass": 36706.0, "length": 327, "protein_name": "Annexin A8", "gene_name": "Anxa8", "organism": "Rat", "refseq_name": "annexin A8", "refseq_ac": "NP_001026824", "gene_names_uniprotkb": "Anxa8", "gene_names_refseq": "Anxa8", "protein_names_uniprotkb": "Annexin A8; Annexin VIII; Annexin-8", "protein_names_refseq": "annexin A8; annexin VIII; annexin-8", "tax_id": 10116, "disease": "pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (rno:306283)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031902 late endosome membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0007596 blood coagulation;GO:0007032 endosome organization;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4FZY0-1", "uniprot_id": "EFHD2_RAT", "mass": 26759.0, "length": 239, "protein_name": "EF-hand domain-containing protein D2", "gene_name": "Efhd2", "organism": "Rat", "refseq_name": "EF-hand domain-containing protein D2", "refseq_ac": "NP_001026818", "gene_names_uniprotkb": "Efhd2; Sws1", "gene_names_refseq": "Efhd2", "protein_names_uniprotkb": "EF-hand domain-containing protein D2; Swiprosin-1", "protein_names_refseq": "EF hand domain containing 2; EF-hand domain-containing protein D2; swiprosin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:298609)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;27992454;29393594;32397496", "class_list": "", "function": "May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance., [UniProtKB]; Study reports that adult rat ventricular cardiomyocytes (ARVC) constitutively express swiprosin-1 on mRNA and protein level and that swiprosin-1 is required to initiate the formation of pseudopodia-like structures (spreading), a process necessary to adapt to culture conditions. Also, the expression level of swiprosin-1 is associated to that of GRK2 and thereby to beta-adrenoceptor responsiveness. Publication Status: Online-Only, [RefSeq, PubMed]; Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0045121 membrane raft", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4FZY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4G061-1", "uniprot_id": "EIF3B_RAT", "mass": 90911.0, "length": 797, "protein_name": "Eukaryotic translation initiation factor 3 subunit B", "gene_name": "Eif3b", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 3 subunit B", "refseq_ac": "NP_001026810", "gene_names_uniprotkb": "Eif3b; EIF3B; EIF3S9; Eif3s9", "gene_names_refseq": "Eif3b; Eif3s9", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit B; Eukaryotic translation initiation factor 3 subunit 9; eIF-3-eta; eIF3b", "protein_names_refseq": "eIF-3-eta; eukaryotic translation initiation factor 3 subunit 9; eukaryotic translation initiation factor 3 subunit B; eukaryotic translation initiation factor 3, subunit 9 (eta)", "tax_id": 10116, "disease": "", "pathway": " (rno:288516); (R-RNO-156827); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "16396499;22673903", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome., [UniProtKB, UniProtKB]; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4G061-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4G063-1", "uniprot_id": "CREL2_RAT", "mass": 38251.0, "length": 349, "protein_name": "Protein disulfide isomerase Creld2", "gene_name": "Creld2", "organism": "Rat", "refseq_name": "protein disulfide isomerase Creld2 precursor", "refseq_ac": "NP_001032285", "gene_names_uniprotkb": "Creld2", "gene_names_refseq": "Creld2; RGD1310614", "protein_names_uniprotkb": "Protein disulfide isomerase Creld2; 5.3.4.1; Cysteine-rich with EGF-like domain protein 2", "protein_names_refseq": "cysteine-rich with EGF-like domain protein 2; cysteine-rich with EGF-like domains 2; protein disulfide isomerase Creld2 precursor; protein disulfide isomerase Creld2", "tax_id": 10116, "disease": "", "pathway": " (rno:362978)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16238698", "class_list": "", "function": "Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4G063-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4G064-1", "uniprot_id": "COQ5_RAT", "mass": 37301.0, "length": 327, "protein_name": "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial", "gene_name": "Coq5", "organism": "Rat", "refseq_name": "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor", "refseq_ac": "NP_001034111", "gene_names_uniprotkb": "Coq5", "gene_names_refseq": "Coq5; RGD1310857", "protein_names_uniprotkb": "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; 2.1.1.201; Ubiquinone biosynthesis methyltransferase COQ5", "protein_names_refseq": "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor; 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; coenzyme Q5 homolog, methyltransferase; ubiquinone biosynthesis methyltransferase COQ5, mitochondrial", "tax_id": 10116, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 9 (Disease Ontology:DOID:0112138)", "pathway": " (rno:304542); (R-RNO-2142789)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Methyltransferase required for the conversion of 2-decaprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.130;2.1.1.201;2.7.-.-;2.1.1.-;2.1.1.114;2.1.1.64;1.14.13.253;1.14.15.45;1.14.15.46", "go_molecular_function": "GO:0008425 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4G064-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KLH5-1", "uniprot_id": "AGFG1_RAT", "mass": 58170.0, "length": 561, "protein_name": "Arf-GAP domain and FG repeat-containing protein 1", "gene_name": "Agfg1", "organism": "Rat", "refseq_name": "arf-GAP domain and FG repeat-containing protein 1", "refseq_ac": "NP_001129068", "gene_names_uniprotkb": "Agfg1; Agfg1-ps1; Hrb; Rip", "gene_names_refseq": "Agfg1", "protein_names_uniprotkb": "Arf-GAP domain and FG repeat-containing protein 1; HIV-1 Rev-binding protein homolog; Nucleoporin-like protein RIP", "protein_names_refseq": "HIV-1 Rev-binding protein homolog; arf-GAP domain and FG repeat-containing protein 1; arf-GAP domain and FG repeats-containing protein 1; nucleoporin-like protein RIP", "tax_id": 10116, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311)", "pathway": " (rno:363266); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15340146;22673903;34502162", "class_list": "", "function": "Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0031410 cytoplasmic vesicle;GO:0042995 cell projection", "go_biological_process": "GO:0001675 acrosome assembly;GO:0007289 spermatid nucleus differentiation;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q4KLH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KLM5-1", "uniprot_id": "ABT1_RAT", "mass": 30620.0, "length": 268, "protein_name": "Activator of basal transcription 1", "gene_name": "Abt1", "organism": "Rat", "refseq_name": "activator of basal transcription 1", "refseq_ac": "NP_001020845", "gene_names_uniprotkb": "Abt1", "gene_names_refseq": "Abt1", "protein_names_uniprotkb": "Activator of basal transcription 1", "protein_names_refseq": "activator of basal transcription 1", "tax_id": 10116, "disease": "", "pathway": " (rno:306960)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10648625", "class_list": "", "function": "May be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KLZ4-1", "uniprot_id": "CL060_RAT", "mass": 27389.0, "length": 243, "protein_name": "Uncharacterized protein C12orf60 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "uncharacterized protein C12orf60 homolog", "refseq_ac": "NP_001032886", "gene_names_uniprotkb": "", "gene_names_refseq": "C4h12orf60", "protein_names_uniprotkb": "Uncharacterized protein C12orf60 homolog", "protein_names_refseq": "uncharacterized protein C12orf60 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500354)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KM52-1", "uniprot_id": "BLNK_RAT", "mass": 50634.0, "length": 457, "protein_name": "B-cell linker protein", "gene_name": "Blnk", "organism": "Rat", "refseq_name": "B-cell linker protein", "refseq_ac": "NP_001020938", "gene_names_uniprotkb": "Blnk", "gene_names_refseq": "Blnk", "protein_names_uniprotkb": "B-cell linker protein; Cytoplasmic adapter protein", "protein_names_refseq": "B-cell linker protein; cytoplasmic adapter protein", "tax_id": 10116, "disease": "agammaglobulinemia 4 (Disease Ontology:DOID:0060027); agammaglobulinemia (Disease Ontology:DOID:2583)", "pathway": " (rno:499356); (R-RNO-983695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;29393594;34521030", "class_list": "", "function": "Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis (By similarity)., [UniProtKB]; Silencing BLNK protects against interleukin-1beta-induced chondrocyte injury through the NF-kappaB signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0008289 lipid binding;GO:0042169 SH2 domain binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010628 positive regulation of gene expression;GO:0035556 intracellular signal transduction;GO:0042113 B cell activation;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4KM52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KM65-1", "uniprot_id": "CPSF5_RAT", "mass": 26240.0, "length": 227, "protein_name": "Cleavage and polyadenylation specificity factor subunit 5", "gene_name": "Nudt21", "organism": "Rat", "refseq_name": "cleavage and polyadenylation specificity factor subunit 5", "refseq_ac": "NP_001034093", "gene_names_uniprotkb": "Nudt21; Cpsf5", "gene_names_refseq": "Cpsf5; Nudt21", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 5; Nucleoside diphosphate-linked moiety X motif 21; Nudix hydrolase 21; Nudix motif 21", "protein_names_refseq": "cleavage and polyadenylation specific factor 5; cleavage and polyadenylation specificity factor subunit 5; nucleoside diphosphate-linked moiety X motif 21; nudix (nucleoside diphosphate linked moiety X)-type motif 21; nudix motif 21", "tax_id": 10116, "disease": "", "pathway": " (rno:291877); (R-RNO-73856); (R-RNO-77595); (R-RNO-9770562)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22898046", "class_list": "", "function": "Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7. Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function. Binds to chromatin. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Taken together, these results indicate that endogenous CFIm may promote neuritogenesis in developing neurons by coordinating events upstream of NGF-induced RhoA inactivation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016604 nuclear body;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0030154 cell differentiation;GO:0051262 protein tetramerization;GO:0010608 post-transcriptional regulation of gene expression;GO:0051290 protein heterotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QQT2-1", "uniprot_id": "F118B_RAT", "mass": 39423.0, "length": 350, "protein_name": "Protein FAM118B", "gene_name": "Fam118b", "organism": "Rat", "refseq_name": "protein FAM118B", "refseq_ac": "NP_001020454", "gene_names_uniprotkb": "Fam118b", "gene_names_refseq": "Fam118b; Ppp4r1l; RGD1307173; Siral1", "protein_names_uniprotkb": "Protein FAM118B", "protein_names_refseq": "family with sequence similarity 118, member B; protein FAM118B", "tax_id": 10116, "disease": "", "pathway": " (rno:315549)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in Cajal bodies formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0015030 Cajal body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QQT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QQT6-1", "uniprot_id": "BRX1_RAT", "mass": 41115.0, "length": 352, "protein_name": "Ribosome biogenesis protein BRX1 homolog", "gene_name": "Brix1", "organism": "Rat", "refseq_name": "ribosome biogenesis protein BRX1 homolog", "refseq_ac": "NP_001025086", "gene_names_uniprotkb": "Brix1; Brix; Bxdc2", "gene_names_refseq": "Brix1; Bxdc2; RGD1308508", "protein_names_uniprotkb": "Ribosome biogenesis protein BRX1 homolog; Brix domain-containing protein 2", "protein_names_refseq": "BRX1, biogenesis of ribosomes; brix domain containing 2; brix domain-containing protein 2; ribosome biogenesis protein BRX1 homolog; ribosome biogenesis protein Brix", "tax_id": 10116, "disease": "", "pathway": " (rno:294799)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for biogenesis of the 60S ribosomal subunit., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QQT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QQV8-1", "uniprot_id": "CHMP5_RAT", "mass": 24576.0, "length": 219, "protein_name": "Charged multivesicular body protein 5", "gene_name": "Chmp5", "organism": "Rat", "refseq_name": "charged multivesicular body protein 5", "refseq_ac": "NP_001020581", "gene_names_uniprotkb": "Chmp5", "gene_names_refseq": "Chmp5; RGD1305968", "protein_names_uniprotkb": "Charged multivesicular body protein 5; Chromatin-modifying protein 5", "protein_names_refseq": "charged multivesicular body protein 5; chromatin-modifying protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:297995); (R-RNO-917729)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RK31", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0039702 viral budding via host ESCRT complex;GO:0071985 multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QQV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QR71-1", "uniprot_id": "CPVL_RAT", "mass": 55146.0, "length": 478, "protein_name": "Probable serine carboxypeptidase CPVL", "gene_name": "CPVL; Cpvl", "organism": "Rat", "refseq_name": "probable serine carboxypeptidase CPVL precursor", "refseq_ac": "NP_001025098", "gene_names_uniprotkb": "CPVL; Cpvl", "gene_names_refseq": "Cpvl", "protein_names_uniprotkb": "Probable serine carboxypeptidase CPVL; 3.4.16.-", "protein_names_refseq": "probable serine carboxypeptidase CPVL precursor; probable serine carboxypeptidase CPVL", "tax_id": 10116, "disease": "", "pathway": " (rno:502774)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004185 serine-type carboxypeptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QR71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4QR77-1", "uniprot_id": "CMI2A_RAT", "mass": 36993.0, "length": 321, "protein_name": "Ciliary microtubule inner protein 2A", "gene_name": "Cimip2a", "organism": "Rat", "refseq_name": "ciliary microtubule inner protein 2A", "refseq_ac": "NP_001020865", "gene_names_uniprotkb": "Cimip2a; Fam166a", "gene_names_refseq": "Cimip2a; Fam166a", "protein_names_uniprotkb": "Ciliary microtubule inner protein 2A", "protein_names_refseq": "ciliary microtubule inner protein 2A; family with sequence similarity 166, member A; protein FAM166A", "tax_id": 10116, "disease": "", "pathway": " (rno:311797)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. Binds to the intra-tubulin interfaces., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0036064 ciliary basal body;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QR77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7A5-1", "uniprot_id": "CK024_RAT", "mass": 48211.0, "length": 477, "protein_name": "Uncharacterized protein C11orf24 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "uncharacterized protein C11orf24 homolog precursor", "refseq_ac": "NP_001020854", "gene_names_uniprotkb": "", "gene_names_refseq": "C1h11orf24; RGD1311946", "protein_names_uniprotkb": "Uncharacterized protein C11orf24 homolog", "protein_names_refseq": "uncharacterized protein C11orf24 homolog precursor; uncharacterized protein C11orf24 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:309145)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 10, "predicted_n_glycosites": 4, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7A5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7C1-1", "uniprot_id": "CEP43_RAT", "mass": 43012.0, "length": 399, "protein_name": "Centrosomal protein 43", "gene_name": "Cep43", "organism": "Rat", "refseq_name": "centrosomal protein 43 isoform 1", "refseq_ac": "NP_001094478", "gene_names_uniprotkb": "Cep43; Fgfr1op", "gene_names_refseq": "Cep43; Fgfr1op", "protein_names_uniprotkb": "Centrosomal protein 43; FGFR1 oncogene partner", "protein_names_refseq": "Fgfr1 oncogene partner; centrosomal protein 43 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:683722); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-8854518)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Required for anchoring microtubules to the centrosomes. Required for ciliation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0030292 protein tyrosine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration;GO:0006469 negative regulation of protein kinase activity;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7D8-1", "uniprot_id": "RMP24_RAT", "mass": 24202.0, "length": 218, "protein_name": "Ribonuclease MRP protein subunit p24", "gene_name": "Rmp24", "organism": "Rat", "refseq_name": "ribonuclease MRP protein subunit p24", "refseq_ac": "NP_001020076", "gene_names_uniprotkb": "Rmp24", "gene_names_refseq": "C18h18orf21; Rmp24", "protein_names_uniprotkb": "Ribonuclease MRP protein subunit p24", "protein_names_refseq": "UPF0711 protein C18orf21 homolog; ribonuclease MRP protein subunit p24", "tax_id": 10116, "disease": "", "pathway": " (rno:498830)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specific component of the MRP ribonucleoprotein endoribonuclease, Rnase/Mrp complex, a ribonucleoprotein complex involved in pre-rRNA processing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0006396 RNA processing;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7D8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V7F2-1", "uniprot_id": "CREL1_RAT", "mass": 45697.0, "length": 420, "protein_name": "Protein disulfide isomerase Creld1", "gene_name": "Creld1", "organism": "Rat", "refseq_name": "protein disulfide isomerase Creld1 precursor", "refseq_ac": "NP_001019954", "gene_names_uniprotkb": "Creld1", "gene_names_refseq": "Creld1", "protein_names_uniprotkb": "Protein disulfide isomerase Creld1; 5.3.4.1; Cysteine-rich with EGF-like domain protein 1", "protein_names_refseq": "cysteine-rich with EGF-like domain protein 1; cysteine-rich with EGF-like domains 1; protein disulfide isomerase Creld1 precursor; protein disulfide isomerase Creld1", "tax_id": 10116, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); heart septal defect (Disease Ontology:DOID:1681)", "pathway": " (rno:312638)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0045202 synapse", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7F2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V882-1", "uniprot_id": "EPN3_RAT", "mass": 65048.0, "length": 608, "protein_name": "Epsin-3", "gene_name": "Epn3", "organism": "Rat", "refseq_name": "epsin-3 isoform 2", "refseq_ac": "NP_001019962", "gene_names_uniprotkb": "Epn3", "gene_names_refseq": "Epn3", "protein_names_uniprotkb": "Epsin-3; EPS-15-interacting protein 3", "protein_names_refseq": "EPS-15-interacting protein 3; epsin-3 isoform 2; epsin-3-like", "tax_id": 10116, "disease": "", "pathway": " (rno:360605)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030276 clathrin binding;GO:1990175 EH domain binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005634 nucleus;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V885-1", "uniprot_id": "COL12_RAT", "mass": 81546.0, "length": 742, "protein_name": "Collectin-12", "gene_name": "Colec12", "organism": "Rat", "refseq_name": "collectin-12", "refseq_ac": "NP_001020892", "gene_names_uniprotkb": "Colec12; Clp1; Nsr2", "gene_names_refseq": "Colec12", "protein_names_uniprotkb": "Collectin-12; CL-P1; Collectin placenta protein 1; Nurse cell scavenger receptor 2", "protein_names_refseq": "CL-P1; collectin placenta protein 1; collectin-12; nurse cell scavenger receptor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361289)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16868960;31344978", "class_list": "", "function": "Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Also binds to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) (By similarity)., [UniProtKB]; The molecular docking revealed that S-allyl-mercapto-glutathione interacting with Colec12, MARCO (class A), and SCARB1 (class B) scavenger receptors in in vitro tests demonstrates a direct stimulation of immunoglobulin secretion by S-allylmercaptoglutathione (GSSA) in CD19+ B lymphocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q76LC3", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0030169 low-density lipoprotein particle binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0042742 defense response to bacterium;GO:0006910 phagocytosis, recognition;GO:0044857 plasma membrane raft organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V885-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V8A6-1", "uniprot_id": "BL1S6_RAT", "mass": 19703.0, "length": 172, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 6", "gene_name": "Bloc1s6", "organism": "Rat", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 6", "refseq_ac": "NP_001020885", "gene_names_uniprotkb": "Bloc1s6; Pldn", "gene_names_refseq": "Bloc1s6; Pldn", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 6; BLOC-1 subunit 6; Pallid protein homolog; Pallidin", "protein_names_refseq": "BLOC-1 subunit 6; biogenesis of lysosomal organelles complex-1, subunit 6, pallidin; biogenesis of lysosome-related organelles complex 1 subunit 6; pallid protein homolog; pallidin homolog", "tax_id": 10116, "disease": "Hermansky-Pudlak syndrome 9 (Disease Ontology:DOID:0060547); platelet storage pool deficiency (Disease Ontology:DOID:2223); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:317630); (R-RNO-432722)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16760431", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005925 focal adhesion;GO:0016020 membrane;GO:0001725 stress fiber", "go_biological_process": "GO:0031175 neuron projection development;GO:0008089 anterograde axonal transport;GO:0035646 endosome to melanosome transport;GO:0048490 anterograde synaptic vesicle transport;GO:0032402 melanosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8A6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q505I5-1", "uniprot_id": "F133B_RAT", "mass": 28033.0, "length": 245, "protein_name": "Protein FAM133B", "gene_name": "Fam133b", "organism": "Rat", "refseq_name": "protein FAM133B", "refseq_ac": "NP_001019970", "gene_names_uniprotkb": "Fam133b", "gene_names_refseq": "Fam133b; RGD1306302", "protein_names_uniprotkb": "Protein FAM133B", "protein_names_refseq": "protein FAM133B", "tax_id": 10116, "disease": "", "pathway": " (rno:362320)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q505I5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q561R2-1", "uniprot_id": "ADAT3_RAT", "mass": 37704.0, "length": 349, "protein_name": "tRNA-specific adenosine-34 deaminase regulatory subunit ADAT3", "gene_name": "Adat3", "organism": "Rat", "refseq_name": "tRNA-specific adenosine-34 deaminase regulatory subunit ADAT3", "refseq_ac": "NP_001096831", "gene_names_uniprotkb": "Adat3", "gene_names_refseq": "Adat3", "protein_names_uniprotkb": "tRNA-specific adenosine-34 deaminase regulatory subunit ADAT3", "protein_names_refseq": "adenosine deaminase, tRNA-specific 3, TAD3 homolog; probable inactive tRNA-specific adenosine deaminase-like protein 3; tRNA-specific adenosine deaminase-like protein 3; tRNA-specific adenosine-34 deaminase regulatory subunit ADAT3; tRNA-specific adenosine-34 deaminase subunit ADAT3", "tax_id": 10116, "disease": "neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies (Disease Ontology:DOID:0081099)", "pathway": " (rno:100125374)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non-catalytic subunit of the tRNA-specific adenosine-34 deaminase complex, composed of the ADAT2 catalytic subunit and the ADAT3 regulatory subunit, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs. Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A. Required for binding of the ADAT2-ADAT3 complex to tRNA through its N-terminus, which rotates with respect to the catalytic domain of the complex, formed by ADAT2 and the ADAT3 C-terminal domain, to position the tRNA anticodon stem-loop correctly in the ADAT2 active site. The ADAT2-ADAT3 complex is required for radial migration of projection neurons in the developing brain cortex, and the catalytic activity of the complex is necessary for this function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q561R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q566Q8-1", "uniprot_id": "CK068_RAT", "mass": 31443.0, "length": 292, "protein_name": "UPF0696 protein C11orf68 homolog", "gene_name": "Bles03", "organism": "Rat", "refseq_name": "UPF0696 protein C11orf68 homolog isoform 1", "refseq_ac": "NP_001019404", "gene_names_uniprotkb": "Bles03", "gene_names_refseq": "Bles03", "protein_names_uniprotkb": "UPF0696 protein C11orf68 homolog; Basophilic leukemia-expressed protein Bles03", "protein_names_refseq": "UPF0696 protein C11orf68 homolog isoform 1; UPF0696 protein C11orf68 homolog; basophilic leukemia-expressed protein Bles03", "tax_id": 10116, "disease": "", "pathway": " (rno:266609)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16511166;29393594", "class_list": "", "function": "Structural characterization of the human ortholog., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0H2UHS1;Q8K436", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q566Q8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q568Y2-1", "uniprot_id": "DPH2_RAT", "mass": 52325.0, "length": 489, "protein_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2", "gene_name": "Dph2", "organism": "Rat", "refseq_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2", "refseq_ac": "NP_001015007", "gene_names_uniprotkb": "Dph2", "gene_names_refseq": "Dph2l2; Dph2", "protein_names_uniprotkb": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Diphthamide biosynthesis protein 2; Diphtheria toxin resistance protein 2; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2", "protein_names_refseq": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; DPH2 homolog; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2; diphthamide biosynthesis protein 2; diphtheria toxin resistance protein 2; diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 2", "tax_id": 10116, "disease": "diphthamide deficiency syndrome (Disease Ontology:DOID:0070476); diphthamide deficiency syndrome 2 (Disease Ontology:DOID:0070478)", "pathway": " (rno:298452)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex;GO:0120513 2-(3-amino-3-carboxypropyl)histidine synthase complex", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q568Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q569A3-1", "uniprot_id": "CK087_RAT", "mass": 20530.0, "length": 196, "protein_name": "Uncharacterized protein C11orf87 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "uncharacterized protein C11orf87 homolog precursor", "refseq_ac": "NP_001096824", "gene_names_uniprotkb": "", "gene_names_refseq": "C8h11orf87", "protein_names_uniprotkb": "Uncharacterized protein C11orf87 homolog", "protein_names_refseq": "uncharacterized protein C11orf87 homolog precursor; uncharacterized protein C11orf87 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:100125362)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q569A3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q569A6-1", "uniprot_id": "ERD21_RAT", "mass": 24546.0, "length": 212, "protein_name": "ER lumen protein-retaining receptor 1", "gene_name": "Kdelr1", "organism": "Rat", "refseq_name": "ER lumen protein-retaining receptor 1", "refseq_ac": "NP_001017385", "gene_names_uniprotkb": "Kdelr1", "gene_names_refseq": "Kdelr1", "protein_names_uniprotkb": "ER lumen protein-retaining receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1", "protein_names_refseq": "ER lumen protein-retaining receptor 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL receptor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361577); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005046 KDEL sequence binding;GO:0046923 ER retention sequence binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen;GO:0070231 T cell apoptotic process;GO:0030217 T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q569A6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BJS4-1", "uniprot_id": "FUND1_RAT", "mass": 17159.0, "length": 155, "protein_name": "FUN14 domain-containing protein 1", "gene_name": "Fundc1", "organism": "Rat", "refseq_name": "FUN14 domain-containing protein 1", "refseq_ac": "NP_001020198", "gene_names_uniprotkb": "Fundc1", "gene_names_refseq": "Fundc1", "protein_names_uniprotkb": "FUN14 domain-containing protein 1", "protein_names_refseq": "FUN14 domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:363442); (R-RNO-8934903)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22673903;33106833;34115550;38584135", "class_list": "", "function": "Integral mitochondrial outer-membrane protein that mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs). In turn, mediates angiogenesis and neoangiogenesis through interference with intracellular Ca(2+) communication and regulation of the vascular endothelial growth factor receptor KDR/VEGFR2 expression at both mRNA and protein levels. Also acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality and homeostasis, by interacting with and recruiting LC3 protein family to mitochondria. Mechanistically, recruits DRP1 at ER-mitochondria contact sites leading to DRP1 oligomerization and GTPase activity to facilitate mitochondrial fission during hypoxia. Additionally, plays a role in hepatic ferroptosis by interacting directly with glutathione peroxidase/GPX4 to facilitate its recruitment into mitochondria through TOM/TIM complex where it is degraded by mitophagy., [UniProtKB, UniProtKB]; Mitophagy mediated by HIF-1alpha/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury., [RefSeq, PubMed]; Overexpression of PLK1 relieved the myocardial ischemia-reperfusion injury of rats through inducing the mitophagy and regulating the p-AMPK/FUNDC1 axis., [RefSeq, PubMed]; [Effects of exercises with different durations and intensities on mitochondrial autophagy and FUNDC1 expression in rat skeletal muscles]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0008053 mitochondrial fusion;GO:0000422 autophagy of mitochondrion;GO:0000423 mitophagy;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5BJS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BJU6-1", "uniprot_id": "CRBL2_RAT", "mass": 14019.0, "length": 123, "protein_name": "cAMP-responsive element-binding protein-like 2", "gene_name": "Crebl2", "organism": "Rat", "refseq_name": "cAMP-responsive element-binding protein-like 2", "refseq_ac": "NP_001015027", "gene_names_uniprotkb": "Crebl2", "gene_names_refseq": "Crebl2", "protein_names_uniprotkb": "cAMP-responsive element-binding protein-like 2", "protein_names_refseq": "cAMP-responsive element-binding protein-like 2", "tax_id": 10116, "disease": "", "pathway": " (rno:362453)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0045600 positive regulation of fat cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BJX5-1", "uniprot_id": "F110B_RAT", "mass": 40363.0, "length": 366, "protein_name": "Protein FAM110B", "gene_name": "Fam110b", "organism": "Rat", "refseq_name": "protein FAM110B", "refseq_ac": "NP_001019512", "gene_names_uniprotkb": "Fam110b", "gene_names_refseq": "Fam110b", "protein_names_uniprotkb": "Protein FAM110B", "protein_names_refseq": "protein FAM110B", "tax_id": 10116, "disease": "", "pathway": " (rno:500400)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BK43-1", "uniprot_id": "ESIP1_RAT", "mass": 35965.0, "length": 314, "protein_name": "Epithelial-stromal interaction protein 1", "gene_name": "Epsti1", "organism": "Rat", "refseq_name": "epithelial-stromal interaction protein 1", "refseq_ac": "NP_001037722", "gene_names_uniprotkb": "Epsti1", "gene_names_refseq": "Epsti1; RGD1563207", "protein_names_uniprotkb": "Epithelial-stromal interaction protein 1", "protein_names_refseq": "epithelial stromal interaction 1 (breast); epithelial-stromal interaction protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:498547); (R-RNO-9696273)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0048873 homeostasis of number of cells within a tissue;GO:0071222 cellular response to lipopolysaccharide;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5EBA0-1", "uniprot_id": "ERAL1_RAT", "mass": 48379.0, "length": 437, "protein_name": "GTPase Era, mitochondrial", "gene_name": "Eral1", "organism": "Rat", "refseq_name": "GTPase Era, mitochondrial isoform 2", "refseq_ac": "NP_001013247", "gene_names_uniprotkb": "Eral1", "gene_names_refseq": "Eral1", "protein_names_uniprotkb": "GTPase Era, mitochondrial; ERA-like protein 1", "protein_names_refseq": "ERA-like protein 1; Era (G-protein)-like 1; Era-like 1; GTP-binding protein era homolog; GTPase Era, mitochondrial isoform 2; GTPase Era, mitochondrial", "tax_id": 10116, "disease": "Perrault syndrome 6 (Disease Ontology:DOID:0080256)", "pathway": " (rno:363646); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21143988", "class_list": "", "function": "Nociceptive transmission evoked by Adelta- and C-fiber stimulation could be potentiated by blocking ERalpha in the spinal neurons. Thus, the spinal estrogen may negatively regulate the nociceptive transmission through the activation of ERalpha. Publication Status: Online-Only, [RefSeq, PubMed]; Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A9P4;D4ADH1", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0043024 ribosomal small subunit binding;GO:0019843 rRNA binding;GO:0140691 RNA folding chaperone;GO:0003723 RNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0000028 ribosomal small subunit assembly;GO:0180026 mitochondrial small ribosomal subunit assembly;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EBA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5EZ72-1", "uniprot_id": "ENPP7_RAT", "mass": 49837.0, "length": 439, "protein_name": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 7", "gene_name": "Enpp7", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Enpp7", "gene_names_refseq": "", "protein_names_uniprotkb": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; 3.1.4.12; Alk-SMase; Alkaline sphingomyelin phosphodiesterase; E-NPP 7; Intestinal alkaline sphingomyelinase; NPP-7", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:303729); (R-RNO-9840310)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15205117;15708357;16255717", "class_list": "", "function": "Choline-specific phosphodiesterase that hydrolyzes sphingomyelin (SM) releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:15708357, PubMed:16255717). Also has phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity (PubMed:16255717). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.12;3.1.4.38;3.1.4.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008081 phosphoric diester hydrolase activity;GO:0004767 sphingomyelin phosphodiesterase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005902 microvillus", "go_biological_process": "GO:2000755 positive regulation of sphingomyelin catabolic process;GO:1904729 regulation of intestinal lipid absorption;GO:0008285 negative regulation of cell population proliferation;GO:0055089 fatty acid homeostasis;GO:0044241 lipid digestion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5EZ72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVI9-1", "uniprot_id": "DUS26_RAT", "mass": 23947.0, "length": 211, "protein_name": "Dual specificity protein phosphatase 26", "gene_name": "Dusp26", "organism": "Rat", "refseq_name": "dual specificity protein phosphatase 26", "refseq_ac": "NP_001012352", "gene_names_uniprotkb": "Dusp26", "gene_names_refseq": "Dusp26; RGD1310090", "protein_names_uniprotkb": "Dual specificity protein phosphatase 26; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity phosphatase 26 (putative); dual specificity protein phosphatase 26", "tax_id": 10116, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (rno:306527)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38705402", "class_list": "", "function": "Dual-specificity phosphatase 26 protects against kidney injury caused by ischaemia-reperfusion through restraint of TAK1-JNK/p38-mediated apoptosis and inflammation of renal tubular epithelial cells., [RefSeq, PubMed]; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.16;2.7.10.1;3.1.3.53;3.1.3.2;3.1.3.52;3.1.3.21;3.1.3.18;3.1.3.67;3.1.3.-;3.1.3.27;3.1.3.5;2.7.11.22;3.1.3.74", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0002039 p53 binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045785 positive regulation of cell adhesion;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0006470 protein dephosphorylation;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVK8-1", "uniprot_id": "AL14E_RAT", "mass": 31112.0, "length": 276, "protein_name": "ARL14 effector protein", "gene_name": "Arl14ep", "organism": "Rat", "refseq_name": "ARL14 effector protein", "refseq_ac": "NP_001014067", "gene_names_uniprotkb": "Arl14ep; Arf7ep", "gene_names_refseq": "ARF7EP; Arl14ep; RGD1311463", "protein_names_uniprotkb": "ARL14 effector protein; ARF7 effector protein", "protein_names_refseq": "ADP-ribosylation factor like GTPase 14 effector protein; ADP-ribosylation factor-like 14 effector protein; ARF7 effector protein; ARL14 effector protein; uncharacterized protein C11orf46 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:311279)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005925 focal adhesion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVM5-1", "uniprot_id": "CR3L3_RAT", "mass": 50862.0, "length": 470, "protein_name": "Cyclic AMP-responsive element-binding protein 3-like protein 3", "gene_name": "Creb3l3", "organism": "Rat", "refseq_name": "cyclic AMP-responsive element-binding protein 3-like protein 3", "refseq_ac": "NP_001012115", "gene_names_uniprotkb": "Creb3l3", "gene_names_refseq": "Creb3l3", "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H; cAMP-responsive element-binding protein 3-like protein 3", "protein_names_refseq": "cAMP-responsive element-binding protein 3-like protein 3; cyclic AMP-responsive element-binding protein 3-like protein 3; transcription factor CREB-H", "tax_id": 10116, "disease": "", "pathway": " (rno:314638); (R-RNO-8874211)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15800215;21693703;26007286", "class_list": "", "function": "A novel mechanism of action of activated CB1R signaling to induce hepatic gluconeogenesis via direct activation of CREBH, [RefSeq, PubMed]; Data suggest that expression of hepatocyte Crebh and Insig1/Insig2a (insulin induced gene products 1/2) can be up-regulated by dietary factors (here, dietary supplementation with R-alpha-lipoic acid, an anti-hypertriglyceridemic agent)., [RefSeq, PubMed]; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. Binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes (By similarity). May be involved in growth suppression. Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034976 response to endoplasmic reticulum stress;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5FVM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FVR4-1", "uniprot_id": "ERI1_RAT", "mass": 39580.0, "length": 345, "protein_name": "3'-5' exoribonuclease 1", "gene_name": "Eri1", "organism": "Rat", "refseq_name": "3'-5' exoribonuclease 1", "refseq_ac": "NP_001014165", "gene_names_uniprotkb": "Eri1; Thex1", "gene_names_refseq": "Eri1; RGD1308378; Thex1", "protein_names_uniprotkb": "3'-5' exoribonuclease 1; 3.1.13.1; Histone mRNA 3'-exonuclease 1", "protein_names_refseq": "3 ' exoribonuclease; 3' exoribonuclease; 3'-5' exoribonuclease 1; histone mRNA 3'-exonuclease 1; three prime histone mRNA exonuclease 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361159); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient 3'-end histone mRNA exonuclease activity and degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs (By similarity). Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA (By similarity). Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. In vitro, does not have sequence specificity. In vitro, has weak DNA exonuclease activity. In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours (By similarity). ERI1-mediated RNA metabolism plays a key role in chondrogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.78;3.1.13.-;3.1.13.1;3.1.-.-", "go_molecular_function": "GO:0071207 histone pre-mRNA stem-loop binding;GO:0008859 exoribonuclease II activity;GO:0046872 metal ion binding;GO:0008408 3'-5' exonuclease activity;GO:0019843 rRNA binding", "go_cellular_component": "GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0031125 rRNA 3'-end processing;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0000460 maturation of 5.8S rRNA;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0060906 negative regulation of regulatory ncRNA-mediated heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FWT1-1", "uniprot_id": "FA98A_RAT", "mass": 55070.0, "length": 515, "protein_name": "Protein FAM98A", "gene_name": "Fam98a", "organism": "Rat", "refseq_name": "protein FAM98A", "refseq_ac": "NP_001014095", "gene_names_uniprotkb": "Fam98a", "gene_names_refseq": "Fam98a; RGD1305486", "protein_names_uniprotkb": "Protein FAM98A", "protein_names_refseq": "protein FAM98A", "tax_id": 10116, "disease": "", "pathway": " (rno:313873)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Positively stimulates PRMT1-induced protein arginine methylation. Involved in skeletal homeostasis. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008276 protein methyltransferase activity", "go_cellular_component": "GO:0072669 tRNA-splicing ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0006479 protein methylation;GO:0032418 lysosome localization;GO:1900029 positive regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5FWT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I0I4-1", "uniprot_id": "DMAC2_RAT", "mass": 28508.0, "length": 254, "protein_name": "Distal membrane-arm assembly complex protein 2", "gene_name": "Dmac2", "organism": "Rat", "refseq_name": "distal membrane-arm assembly complex protein 2", "refseq_ac": "NP_001009705", "gene_names_uniprotkb": "Dmac2; Atp5sl", "gene_names_refseq": "Atp5sl; Dmac2", "protein_names_uniprotkb": "Distal membrane-arm assembly complex protein 2; ATP synthase subunit s-like protein", "protein_names_refseq": "ATP synthase subunit s-like protein; ATP5S-like; distal membrane arm assembly complex 2; distal membrane-arm assembly complex protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361520); (R-RNO-6799198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I0L6-1", "uniprot_id": "CYTIP_RAT", "mass": 39957.0, "length": 359, "protein_name": "Cytohesin-interacting protein", "gene_name": "Cytip", "organism": "Rat", "refseq_name": "cytohesin-interacting protein", "refseq_ac": "NP_001012086", "gene_names_uniprotkb": "Cytip; Pscdbp", "gene_names_refseq": "Cytip; Pscdbp", "protein_names_uniprotkb": "Cytohesin-interacting protein; Pleckstrin homology Sec7 and coiled-coil domain-binding protein", "protein_names_refseq": "cytohesin-interacting protein; pleckstrin homology Sec7 and coiled-coil domain-binding protein; pleckstrin homology, Sec7 and coiled-coil domains, binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:311047)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0030155 regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M840-1", "uniprot_id": "G0S2_RAT", "mass": 11232.0, "length": 103, "protein_name": "G0/G1 switch protein 2", "gene_name": "G0s2", "organism": "Rat", "refseq_name": "G0/G1 switch protein 2", "refseq_ac": "NP_001009632", "gene_names_uniprotkb": "G0s2", "gene_names_refseq": "G0s2", "protein_names_uniprotkb": "G0/G1 switch protein 2; G0S2-like protein", "protein_names_refseq": "G0/G1 switch gene 2; G0/G1 switch protein 2; G0S2-like protein; putative lymphocyte G0/G1 switch", "tax_id": 10116, "disease": "", "pathway": " (rno:289388)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "24344269;25448749;25588877;25811590;26511521;27590244;27624922", "class_list": "", "function": "Administration of progesterone resulted in an increase in the expression of Abhd5 gene (whose product increases ATGL activity) and G0s2 gene (whose product decreases ATGL activity) in the inguinal white adipose tissue of female rats., [RefSeq, PubMed]; G0/G1 switch gene 2 has a role as a positive regulator of oxidative phosphorylation, [RefSeq, PubMed]; Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers., [UniProtKB]; Report increased levels of ATGL and its inhibitor G0S2 following endurance training in metabolically different rat skeletal muscles., [RefSeq, PubMed]; Results indicate that G0S2 acts as a prosurvival molecule in endothelial cells., [RefSeq, PubMed]; Results of the present study indicate that hepatic G0s2 protein may promote hepatic insulin resistance by exacerbating hepatic steatosis, [RefSeq, PubMed]; These data suggest that the content of G0S2 relative to the lipase in skeletal muscle would not predict lipolytic potential. Publication Status: Online-Only, [RefSeq, PubMed]; Upregulation of Pnpla2 expression and activation of ATGL (due to an increase in ABHD5 and decrease in G0S2 levels), as well as a coordinated interplay of these genes with Lipe in mesenteric WAT, contribute, at least in part, to an increase in the concentration of circulating NEFA in rats with reduced fat mass., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0097191 extrinsic apoptotic signaling pathway;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5M840-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M864-1", "uniprot_id": "BORA_RAT", "mass": 57633.0, "length": 534, "protein_name": "Protein aurora borealis", "gene_name": "Bora", "organism": "Rat", "refseq_name": "protein aurora borealis", "refseq_ac": "NP_001014019", "gene_names_uniprotkb": "Bora", "gene_names_refseq": "Bora; RGD1309522", "protein_names_uniprotkb": "Protein aurora borealis", "protein_names_refseq": "protein aurora borealis", "tax_id": 10116, "disease": "", "pathway": " (rno:306102); (R-RNO-2565942); (R-RNO-69273)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the activation of AURKA at the onset of mitosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0072687 meiotic spindle", "go_biological_process": "GO:0051301 cell division;GO:0032880 regulation of protein localization;GO:0060236 regulation of mitotic spindle organization;GO:0007088 regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M864-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M9F0-1", "uniprot_id": "CSTP1_RAT", "mass": 37476.0, "length": 331, "protein_name": "Centriolar satellite-associated tubulin polyglutamylase complex regulator 1", "gene_name": "Cstpp1", "organism": "Rat", "refseq_name": "centriolar satellite-associated tubulin polyglutamylase complex regulator 1 isoform 1", "refseq_ac": "NP_001013940", "gene_names_uniprotkb": "Cstpp1", "gene_names_refseq": "Cstpp1; RGD1309540", "protein_names_uniprotkb": "Centriolar satellite-associated tubulin polyglutamylase complex regulator 1", "protein_names_refseq": "UPF0705 protein C11orf49 homolog; centriolar satellite-associated tubulin polyglutamylase complex regulator 1 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:295930)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005874 microtubule;GO:0034451 centriolar satellite", "go_biological_process": "GO:0061635 regulation of protein complex stability", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M9F0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M9G9-1", "uniprot_id": "FAKD4_RAT", "mass": 71181.0, "length": 629, "protein_name": "FAST kinase domain-containing protein 4", "gene_name": "Tbrg4", "organism": "Rat", "refseq_name": "FAST kinase domain-containing protein 4", "refseq_ac": "NP_001012154", "gene_names_uniprotkb": "Tbrg4", "gene_names_refseq": "Tbrg4", "protein_names_uniprotkb": "FAST kinase domain-containing protein 4; Protein TBRG4; Transforming growth factor beta regulator 4", "protein_names_refseq": "FAST kinase domain-containing protein 4; protein TBRG4; transforming growth factor beta regulated gene 4", "tax_id": 10116, "disease": "", "pathway": " (rno:360977)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0000963 mitochondrial RNA processing;GO:0044528 regulation of mitochondrial mRNA stability;GO:0090615 mitochondrial mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M9G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M9I1-1", "uniprot_id": "CL2DR_RAT", "mass": 26114.0, "length": 235, "protein_name": "C-type lectin domain family 2 member D-related protein", "gene_name": "", "organism": "Rat", "refseq_name": "C-type lectin domain family 2 member D-related protein", "refseq_ac": "NP_001019508", "gene_names_uniprotkb": "", "gene_names_refseq": "Clec2d2l3", "protein_names_uniprotkb": "C-type lectin domain family 2 member D-related protein", "protein_names_refseq": "C-type lectin domain family 2 member D-related protein-like; C-type lectin domain family 2 member D-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:500331)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lectin-type cell surface receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M9I1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5MJ12-1", "uniprot_id": "FXL16_RAT", "mass": 51851.0, "length": 479, "protein_name": "F-box/LRR-repeat protein 16", "gene_name": "Fbxl16", "organism": "Rat", "refseq_name": "F-box/LRR-repeat protein 16", "refseq_ac": "NP_001009504", "gene_names_uniprotkb": "Fbxl16; Scirr1", "gene_names_refseq": "Fbxl16; Scirr1", "protein_names_uniprotkb": "F-box/LRR-repeat protein 16; F-box and leucine-rich repeat protein 16; Spinal cord injury and regeneration-related protein 1", "protein_names_refseq": "F-box/LRR-repeat protein 16; spinal cord injury and regeneration related 1; spinal cord injury and regeneration-related protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:494223); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "17603280", "class_list": "", "function": "SCIRR1 ise involved in the succeeding injury and/or repair processes of the injured spinal cord, [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5MJ12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PPH0-1", "uniprot_id": "ENOPH_RAT", "mass": 28875.0, "length": 261, "protein_name": "Enolase-phosphatase E1", "gene_name": "Enoph1", "organism": "Rat", "refseq_name": "enolase-phosphatase E1", "refseq_ac": "NP_001009391", "gene_names_uniprotkb": "Enoph1; ENOPH1; MASA; Masa", "gene_names_refseq": "Enoph1; RGD1309016", "protein_names_uniprotkb": "Enolase-phosphatase E1; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; 3.1.3.77; MASA homolog", "protein_names_refseq": "2,3-diketo-5-methylthio-1-phosphopentane phosphatase; E-1 enzyme; MASA homolog; enolase-phosphatase E1", "tax_id": 10116, "disease": "", "pathway": " (rno:305177); (R-RNO-1237112)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.77", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0043874 acireductone synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PPH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PQM8-1", "uniprot_id": "ATOSB_RAT", "mass": 56990.0, "length": 538, "protein_name": "Atos homolog protein B", "gene_name": "Atosb", "organism": "Rat", "refseq_name": "atos homolog protein B", "refseq_ac": "NP_001013953", "gene_names_uniprotkb": "Atosb; Fam214b", "gene_names_refseq": "Atosb; Fam214b; RGD1311249", "protein_names_uniprotkb": "Atos homolog protein B", "protein_names_refseq": "atos homolog protein B; family with sequence similarity 214, member B; protein FAM214B", "tax_id": 10116, "disease": "", "pathway": " (rno:298201)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription regulator that may syncronize transcriptional and translational programs., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PQN2-1", "uniprot_id": "BFAR_RAT", "mass": 53024.0, "length": 450, "protein_name": "Bifunctional apoptosis regulator", "gene_name": "Bfar", "organism": "Rat", "refseq_name": "bifunctional apoptosis regulator", "refseq_ac": "NP_001013143", "gene_names_uniprotkb": "Bfar", "gene_names_refseq": "Bfar; RGD1305537", "protein_names_uniprotkb": "Bifunctional apoptosis regulator; 2.3.2.27", "protein_names_refseq": "bifunctional apoptosis regulator", "tax_id": 10116, "disease": "", "pathway": " (rno:304709)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Membrane-bound E3 ubiquitin ligase that plays a role in several processes including apoptosis regulation or reticulum endoplasmic stress. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Contributes to the dynamic control of IRE1/ERN1 signaling during ER stress by inducing BAX inhibitor 1/TMBIM6 proteasomal degradation. Promotes the activation of TGF-beta signaling by mediating the 'Lys-63'-linked ubiquitination of TGFBR1 which is critical to activate the pathway. Together with NGFR, negatively regulates NF-kappa-B and JNK-related signaling pathways. Promotes the proteasome-mediated degradation of PNPLA3, a protein involveld in lipid metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0061630 ubiquitin protein ligase activity;GO:0089720 caspase binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJN9-1", "uniprot_id": "CLBA1_RAT", "mass": 34736.0, "length": 321, "protein_name": "Uncharacterized protein CLBA1", "gene_name": "Clba1", "organism": "Rat", "refseq_name": "uncharacterized protein CLBA1", "refseq_ac": "NP_001008378", "gene_names_uniprotkb": "Clba1", "gene_names_refseq": "Clba1; RGD1307315", "protein_names_uniprotkb": "Uncharacterized protein CLBA1; Clathrin-binding box of aftiphilin-containing protein 1", "protein_names_refseq": "clathrin-binding box of aftiphilin-containing protein 1; uncharacterized protein C14orf79 homolog; uncharacterized protein CLBA1", "tax_id": 10116, "disease": "", "pathway": " (rno:362793)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030276 clathrin binding", "go_cellular_component": "GO:0032588 trans-Golgi network membrane;GO:0030121 AP-1 adaptor complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYU4-1", "uniprot_id": "CRYM_RAT", "mass": 33554.0, "length": 313, "protein_name": "Ketimine reductase mu-crystallin", "gene_name": "Crym", "organism": "Rat", "refseq_name": "ketimine reductase mu-crystallin", "refseq_ac": "NP_446407", "gene_names_uniprotkb": "Crym", "gene_names_refseq": "CDK108; Crym", "protein_names_uniprotkb": "Ketimine reductase mu-crystallin; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase; 1.5.1.1; 1.5.1.25; CDK108; NADP-regulated thyroid-hormone-binding protein; P2C/Pyr2C reductase", "protein_names_refseq": "1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase; NADP-regulated thyroid-hormone-binding protein; P2C/Pyr2C reductase; ketimine reductase mu-crystallin; mu-crystallin homolog; thiomorpholine-carboxylate dehydrogenase", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 40 (Disease Ontology:DOID:0110566)", "pathway": " (rno:117024); (R-RNO-71064)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18448257;18683930;20018174;24646676;29603402", "class_list": "", "function": "CRYM expression increases and sustains the T3 responsiveness of genes in cells, especially with alteration of the pericellular T3 concentration., [RefSeq, PubMed]; Catalyzes the NAD(P)H-dependent reduction of imine double bonds of a number of cyclic ketimine substrates, including sulfur-containing cyclic ketimines. Under physiological conditions, it efficiently catalyzes delta(1)-piperideine-2-carboxylate (P2C) and delta(1)-pyrroline-2-carboxylate (Pyr2C) reduction, suggesting a central role in lysine and glutamate metabolism. Additional substrates are delta(2)-thiazoline-2-carboxylate (T2C), 3,4-dehydrothiomorpholine-3-carboxylate (AECK), and (R)-lanthionine ketimine (LK) that is reduced at very low rate compared to other substrates (By similarity). Also catalyzes the NAD(P)H-dependent reduction of (S)-cystathionine ketimine (CysK) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Crym protein was predominantly distributed in the fibrocytes in the spiral ligament, as well as the stria vascularis of cochlea in rats., [RefSeq, PubMed]; Results suggest that mu-crystallin may play roles in development of cortical and hippocampal pyramidal cells in the early postnatal period, and in the later period, performs cell-specific functions in selected neuronal populations., [RefSeq, PubMed]; This is the first report linking hyperglycemia with thyroid hormone binding protein CRYM and suggests that the role of CRYM in diabetic complications should be further investigated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.1.25;1.5.1.1", "go_molecular_function": "GO:0047127 thiomorpholine-carboxylate dehydrogenase activity;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity;GO:0042562 hormone binding;GO:0070324 thyroid hormone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006839 mitochondrial transport;GO:0007605 sensory perception of sound;GO:0009725 response to hormone;GO:0033280 response to vitamin D", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QYU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZGQ5-1", "uniprot_id": "NEK8_RAT", "mass": 75254.0, "length": 698, "protein_name": "Serine/threonine-protein kinase Nek8", "gene_name": "Nek8", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase Nek8", "refseq_ac": "NP_001099274", "gene_names_uniprotkb": "Nek8; Jck", "gene_names_refseq": "Nek8", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek8; 2.7.11.1; Never in mitosis A-related kinase 8; NimA-related protein kinase 8", "protein_names_refseq": "NIMA (never in mitosis gene a)- related kinase 8; NIMA (never in mitosis gene a)-related expressed kinase 8; never in mitosis A-related kinase 8; nimA-related protein kinase 8; serine/threonine-protein kinase Nek8", "tax_id": 10116, "disease": "renal-hepatic-pancreatic dysplasia (Disease Ontology:DOID:0060259); amyotrophic lateral sclerosis type 24 (Disease Ontology:DOID:0081378); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); nephronophthisis 9 (Disease Ontology:DOID:0111120)", "pathway": " (rno:287473)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22899815;23793029", "class_list": "", "function": "A novel Nek8 mutation R650C is that occurs within the regulator of chromosome condensation 1 (RCC1)-like region of the protein. Publication Status: Online-Only, [RefSeq, PubMed]; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005930 axoneme;GO:0097546 ciliary base;GO:0097543 ciliary inversin compartment", "go_biological_process": "GO:0035330 regulation of hippo signaling;GO:0007507 heart development;GO:0009887 animal organ morphogenesis;GO:0007368 determination of left/right symmetry;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZGQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7E3N2-1", "uniprot_id": "NCF2_RAT", "mass": 59573.0, "length": 527, "protein_name": "Neutrophil cytosol factor 2", "gene_name": "Ncf2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ncf2", "gene_names_refseq": "", "protein_names_uniprotkb": "Neutrophil cytosol factor 2; NCF-2; Neutrophil NADPH oxidase factor 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); autosomal recessive chronic granulomatous disease 2 (Disease Ontology:DOID:0070191); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); proteinuria (Disease Ontology:DOID:576); rheumatoid arthritis (Disease Ontology:DOID:7148); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-1222556); (R-RNO-1236973); (R-RNO-3299685); (R-RNO-4420097); (R-RNO-5668599); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013423)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "17612411", "class_list": "", "function": "Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0016176 superoxide-generating NADPH oxidase activator activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0045777 positive regulation of blood pressure;GO:0006909 phagocytosis;GO:0034616 response to laminar fluid shear stress;GO:0032570 response to progesterone", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7E3N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZSI8-1", "uniprot_id": "PI51A_RAT", "mass": 60605.0, "length": 546, "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha", "gene_name": "Pip5k1a", "organism": "Rat", "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1", "refseq_ac": "NP_001036086", "gene_names_uniprotkb": "Pip5k1a", "gene_names_refseq": "Pip5k1a; Pip5k1b", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; 2.7.1.68; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase; PIP5K1-alpha; PIP5KIalpha; Phosphatidylinositol 4-phosphate 5-kinase type I alpha; PtdIns(4)P-5-kinase 1 alpha", "protein_names_refseq": "68 kDa type I phosphatidylinositol 4-phosphate 5-kinase; PIP5K1-alpha; PIP5KIalpha; phosphatidylinositol 4-phosphate 5-kinase type I alpha; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta; ptdIns(4)P-5-kinase 1 alpha", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:365865); (R-RNO-1660499); (R-RNO-6811558)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15157668;32686865", "class_list": "", "function": "Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (By similarity). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps. Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B, is required, after stimulation by G protein-coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (By similarity). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes. Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane. Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.68;2.7.1.149", "go_molecular_function": "GO:0005524 ATP binding;GO:0019900 kinase binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0030036 actin cytoskeleton organization;GO:0060326 cell chemotaxis;GO:0048041 focal adhesion assembly;GO:0006661 phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZSI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2U2-1", "uniprot_id": "CRKL_RAT", "mass": 33865.0, "length": 303, "protein_name": "Crk-like protein", "gene_name": "Crkl", "organism": "Rat", "refseq_name": "crk-like protein", "refseq_ac": "NP_001008285", "gene_names_uniprotkb": "Crkl", "gene_names_refseq": "Crkl", "protein_names_uniprotkb": "Crk-like protein", "protein_names_refseq": "crk-like protein-like; crk-like protein; v-crk avian sarcoma virus CT10 oncogene homolog-like", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583); colon carcinoma (Disease Ontology:DOID:1520); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); lung carcinoma (Disease Ontology:DOID:3905); skin cancer (Disease Ontology:DOID:4159); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (rno:287942); (R-RNO-170968); (R-RNO-186763); (R-RNO-8875555); (R-RNO-8875656); (R-RNO-9027284); (R-RNO-912631)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May mediate the transduction of intracellular signals., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0042802 identical protein binding;GO:0030971 receptor tyrosine kinase binding;GO:0035591 signaling adaptor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0098890 extrinsic component of postsynaptic membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:1904888 cranial skeletal system development;GO:0086100 endothelin receptor signaling pathway;GO:0060017 parathyroid gland development;GO:0098749 cerebellar neuron development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2U2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZW91-1", "uniprot_id": "POC1B_RAT", "mass": 53512.0, "length": 477, "protein_name": "POC1 centriolar protein homolog B", "gene_name": "Poc1b", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Poc1b; Wdr51b", "gene_names_refseq": "", "protein_names_uniprotkb": "POC1 centriolar protein homolog B; WD repeat-containing protein 51B", "protein_names_refseq": "", "tax_id": 10116, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); cone-rod dystrophy 20 (Disease Ontology:DOID:0111026)", "pathway": " (rno:100362836)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity. Acts as a positive regulator of centriole elongation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008283 cell population proliferation;GO:0000902 cell morphogenesis;GO:0007338 single fertilization;GO:0001895 retina homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZW91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63028-1", "uniprot_id": "ADDA_RAT", "mass": 80355.0, "length": 735, "protein_name": "Alpha-adducin", "gene_name": "Add1", "organism": "Rat", "refseq_name": "alpha-adducin isoform 1", "refseq_ac": "NP_058686", "gene_names_uniprotkb": "Add1", "gene_names_refseq": "Add1", "protein_names_uniprotkb": "Alpha-adducin; Erythrocyte adducin subunit alpha", "protein_names_refseq": "adducin 1 (alpha); alpha-ADD; alpha-adducin isoform 1; alpha-adducin; erythrocyte adducin subunit alpha", "tax_id": 10116, "disease": "spastic quadriplegic cerebral palsy 3 (Disease Ontology:DOID:0081361); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); hydrocephalus (Disease Ontology:DOID:10908); gastroschisis (Disease Ontology:DOID:11044); familial combined hyperlipidemia (Disease Ontology:DOID:13809); atherosclerosis (Disease Ontology:DOID:1936); cerebral palsy (Disease Ontology:DOID:1969); IgA glomerulonephritis (Disease Ontology:DOID:2986); temporal lobe epilepsy (Disease Ontology:DOID:3328); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:24170); (R-RNO-264870); (R-RNO-5223345)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21451595;22673903;28657654;8543181;8624703", "class_list": "", "function": "Altered expression of renal aquaporins and alpha-adducin polymorphisms may contribute to the establishment of salt-sensitive hypertension., [RefSeq, PubMed]; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3B7D4;Q64722", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005516 calmodulin binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006811 monoatomic ion transport;GO:0071300 cellular response to retinoic acid;GO:0045766 positive regulation of angiogenesis;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q63028-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63603-1", "uniprot_id": "DOCK9_RAT", "mass": 82455.0, "length": 720, "protein_name": "Dedicator of cytokinesis protein 9", "gene_name": "Dock9", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dock9; Trg", "gene_names_refseq": "", "protein_names_uniprotkb": "Dedicator of cytokinesis protein 9; Cdc42 guanine nucleotide exchange factor zizimin-1; Protein TRG", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0012505 endomembrane system", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63603-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2GV06-1", "uniprot_id": "SCOT1_RAT", "mass": 56204.0, "length": 520, "protein_name": "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "gene_name": "Oxct1", "organism": "Rat", "refseq_name": "succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor", "refseq_ac": "NP_001121052", "gene_names_uniprotkb": "Oxct1; Oxct; Scot", "gene_names_refseq": "Oxct1; SCOT", "protein_names_uniprotkb": "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; 2.8.3.5; 3-oxoacid CoA-transferase 1; SCOT-s; SCOT; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; Succinyl-CoA:3-oxoacid CoA transferase", "protein_names_refseq": "scot-S; somatic-type succinyl-CoA:3-oxoacid CoA-transferase; succinyl-CoA:3-ketoacid CoA transferase; succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor; succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial-like; succinyl-CoA:3-oxoacid CoA transferase", "tax_id": 10116, "disease": "carbohydrate metabolic disorder (Disease Ontology:DOID:2978); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:690163); (R-RNO-77108); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "19343716;20460097;27213235;34502162", "class_list": "", "function": "Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (By similarity). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate., [UniProtKB, UniProtKB, UniProtKB]; MRNAs of SCOT and ATP citrate lyase were decreased 55% and 58% and enzyme activities were decreased >70% in pancreatic islets of the GK rat, a model of type 2 diabetes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.5;1.3.8.5;6.2.1.4;4.98.1.1;2.8.3.5;5.6.2.3;2.3.1.-;2.3.1.41;3.4.21.92;3.5.3.1;3.1.2.2;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.2.-;1.1.1.37;6.4.1.3;7.1.2.2;1.4.1.3;1.2.1.3;2.3.1.37;4.2.1.2;2.3.1.9;2.3.3.10;5.3.3.8;1.1.1.30;3.6.4.10;1.2.4.1;1.1.1.42;5.6.1.7;1.3.8.1;2.7.1.23;1.2.4.2;5.3.3.21;2.7.11.2;2.7.11.-;7.1.1.2;1.2.1.36;1.7.1.-;1.2.1.28;1.8.1.4;2.3.3.1;3.4.21.53;1.1.1.41;4.2.1.3", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0007507 heart development;GO:0007584 response to nutrient;GO:0042594 response to starvation;GO:0045471 response to ethanol;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B2GV06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z336-1", "uniprot_id": "DYLT1_RAT", "mass": 12452.0, "length": 113, "protein_name": "Dynein light chain Tctex-type 1", "gene_name": "Dynlt1", "organism": "Rat", "refseq_name": "dynein light chain Tctex-type 1", "refseq_ac": "NP_112608", "gene_names_uniprotkb": "Dynlt1; Tctel1; Tctex-1; Tctex1", "gene_names_refseq": "AGS2; Dynlt1; Tctex1", "protein_names_uniprotkb": "Dynein light chain Tctex-type 1; AGS2; Activator of G protein signaling 2; T-complex testis-specific protein 1 homolog", "protein_names_refseq": "T-complex testis-specific protein 1 homolog; activator of G-protein signaling 2; dynein light chain Tctex-type 1; t-complex testis expressed 1", "tax_id": 10116, "disease": "", "pathway": " (rno:83462); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11746667;12591166;15992542;17491591;22164227;24170091;9804756", "class_list": "", "function": "Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site., [UniProtKB, UniProtKB]; Data suggest that DYNLT1 phosphorylation at serine S82 is involved in microtubule and mitochondria regulation, and their interaction and cooperation contribute to the cellular hypoxic tolerance., [RefSeq, PubMed]; Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. Required for neurite outgrowth. The function in neurogenesis may be regulated by association with a G protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (By similarity). Involved in the regulation of mitotic spindle orientation., [UniProtKB, PubMed, UniProtKB, PubMed]; There are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005819 spindle", "go_biological_process": "GO:0019060 intracellular transport of viral protein in host cell;GO:0035795 negative regulation of mitochondrial membrane permeability;GO:0006886 intracellular protein transport;GO:0010976 positive regulation of neuron projection development;GO:0016358 dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z336-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63270-1", "uniprot_id": "ACOHC_RAT", "mass": 98128.0, "length": 889, "protein_name": "Cytoplasmic aconitate hydratase", "gene_name": "Aco1", "organism": "Rat", "refseq_name": "cytoplasmic aconitate hydratase", "refseq_ac": "NP_059017", "gene_names_uniprotkb": "Aco1; Ireb1; Irebp", "gene_names_refseq": "AH; Aco1; Acon1; IRP1", "protein_names_uniprotkb": "Cytoplasmic aconitate hydratase; 4.2.1.3; Aconitase; Citrate hydro-lyase; IRE-BP 1; IRP1; Iron regulatory protein 1; Iron-responsive element-binding protein 1", "protein_names_refseq": "IRE-BP 1; aconitase 1, soluble; citrate hydro-lyase; cytoplasmic aconitate hydratase; iron regulatory protein 1; iron-responsive element-binding protein 1", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Becker disease (Disease Ontology:DOID:0081335); Thomsen disease (Disease Ontology:DOID:0081336); porphyria (Disease Ontology:DOID:13268); duodenal ulcer (Disease Ontology:DOID:1724); myotonia congenita (Disease Ontology:DOID:2106); myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:50655); (R-RNO-389542); (R-RNO-917937)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1527027;16144863;25106854;25652229;27914013;8041788", "class_list": "", "function": "Bifunctional iron sensor that switches between 2 activities depending on iron availability (By similarity). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:16144863). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:16144863)., [UniProtKB, PubMed, UniProtKB]; Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA., [UniProtKB, UniProtKB, UniProtKB]; Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Human ACO1 is a moonlighting protein that has both aconitase enzyme activity as well as an mRNA binding function., [RefSeq, PubMed]; Iron increases turnover of IRP-1 in kidney cells, while increasing aconitase activity, suggesting that the apoprotein (aconitase-inactive) form is not exclusively responsible for turnover., [RefSeq, PubMed]; Polymer-dependent translocation of IRP-1 in Cd(2+)-exposed cells may underlie effects of Cd(2+) on iron homeostasis., [RefSeq, PubMed]; Proteomic analysis revealed that the expression levels of two mitochondrial proteins, cytochrome bc1 complex2 (UQCRC2, the major component of electron transport chain complex III) and aconitase (an enzyme involved in the tricarboxylic acid cycle), were decreased by homocysteine in neural stem cells, [RefSeq, PubMed]; This gene encodes a member of the aconitase/IPM isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Depending on iron levels in the cytosol, the encoded protein can function as either an aconitase enzyme or as an mRNA binding protein. When cellular iron levels are high, the encoded protein functions as an aconitase, an essential enzyme in the TCA cycle that catalyzes the conversion of citrate to isocitrate. When cellular iron levels are low, the encoded protein regulates iron uptake and utilization by binding to iron-responsive elements in the untranslated regions of mRNAs for genes involved in iron metabolism [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.3", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003723 RNA binding;GO:0003994 aconitate hydratase activity;GO:0046872 metal ion binding;GO:0051538 3 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0001889 liver development;GO:0006099 tricarboxylic acid cycle;GO:0006101 citrate metabolic process;GO:0006417 regulation of translation;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63270-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1A5Q7-1", "uniprot_id": "VWA3A_RAT", "mass": 83254.0, "length": 737, "protein_name": "von Willebrand factor A domain-containing protein 3A", "gene_name": "Vwa3a", "organism": "Rat", "refseq_name": "von Willebrand factor A domain-containing protein 3A isoform 2", "refseq_ac": "NP_001073354", "gene_names_uniprotkb": "Vwa3a", "gene_names_refseq": "RGD1311670; Vwa3a", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 3A", "protein_names_refseq": "von Willebrand factor A domain-containing protein 3A isoform 2; von Willebrand factor A domain-containing protein 3A", "tax_id": 10116, "disease": "", "pathway": " (rno:293449)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5Q7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXP6-1", "uniprot_id": "CTSR2_RAT", "mass": 68266.0, "length": 584, "protein_name": "Cation channel sperm-associated protein 2", "gene_name": "Catsper2", "organism": "Rat", "refseq_name": "cation channel sperm-associated protein 2", "refseq_ac": "NP_001012220", "gene_names_uniprotkb": "Catsper2", "gene_names_refseq": "Catsper2", "protein_names_uniprotkb": "Cation channel sperm-associated protein 2; CatSper2", "protein_names_refseq": "cation channel sperm-associated protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:366174); (R-RNO-1300642)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11675491;22002435;31041823", "class_list": "", "function": "It is feasible to achieve male contraception by silencing the expression of CatSper2, the key protein involved in sperm hyperactivation., [RefSeq, PubMed]; Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005227 calcium-activated cation channel activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0036128 CatSper complex;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece", "go_biological_process": "GO:0009566 fertilization;GO:0006816 calcium ion transport;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AXP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMI1-1", "uniprot_id": "AACS_RAT", "mass": 75040.0, "length": 672, "protein_name": "Acetoacetyl-CoA synthetase", "gene_name": "Aacs", "organism": "Rat", "refseq_name": "acetoacetyl-CoA synthetase", "refseq_ac": "NP_075592", "gene_names_uniprotkb": "Aacs", "gene_names_refseq": "Aacs", "protein_names_uniprotkb": "Acetoacetyl-CoA synthetase; 6.2.1.16", "protein_names_refseq": "AcAc-CoA ligase; acetoacetate-CoA ligase; acetoacetyl-CoA ligase; acetoacetyl-CoA synthetase", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:65984); (R-RNO-77111)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10682835;15992942;16055091;19219059;26776438;3082367", "class_list": "", "function": "AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development, [RefSeq, PubMed]; As acetoacetyl-CoA synthetase was expressed in neural-like cells, ketone bodies are assumed to be utilized for the synthesis of lipidic substances and to cause metabolic disorders in the nervous system of genetically obese rats., [RefSeq, PubMed]; Converts acetoacetate to acetoacetyl-CoA in the cytosol. Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Prenatal nicotine exposure can cause DNA hypermethylation of the AACS promoter in the rat fetal adrenal., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.16", "go_molecular_function": "GO:0005524 ATP binding;GO:0030729 acetoacetate-CoA ligase activity;GO:0031955 short-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001889 liver development;GO:0006631 fatty acid metabolic process;GO:0007584 response to nutrient;GO:0014074 response to purine-containing compound;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JMI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GV29-1", "uniprot_id": "QTGAL_RAT", "mass": 40711.0, "length": 357, "protein_name": "Queuosine-tRNA galactosyltransferase", "gene_name": "Qtgal", "organism": "Rat", "refseq_name": "queuosine-tRNA galactosyltransferase isoform 1", "refseq_ac": "NP_001015035", "gene_names_uniprotkb": "Qtgal; B3gntl1", "gene_names_refseq": "B3gntl1; Qtgal", "protein_names_uniprotkb": "Queuosine-tRNA galactosyltransferase; 2.4.1.-; BGnT-like protein 1; Beta1,3-N-acetylglucosaminyltransferase-like protein 1; Beta3Gn-T-like protein 1; Beta3GnTL1; QTGAL; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1", "protein_names_refseq": "BGnT-like protein 1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1; beta1,3-N-acetylglucosaminyltransferase-like protein 1; beta3Gn-T-like protein 1; beta3GnTL1; queuosine-tRNA galactosyltransferase isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:367384); (R-RNO-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "37992713", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that specifically catalyzes galactosylation of cytoplasmic tRNA(Tyr) modified with queuosine at position 34 (queuosine(34)) (PubMed:37992713). Galactosylates the cyclopentene hydroxyl group of queuosine(34) in tRNA(Tyr) to form galactosyl-queuosine(34) (PubMed:37992713). Mannosylation of queuosine(34) in tRNA(Tyr) is required to slow-down elongation at cognate codons UAC and suppress stop codon readthrough, thereby regulating protein translation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2NKP4", "ec_number_list": "2.4.1.-;2.4.1.206", "go_molecular_function": "GO:0141125 tRNA-queuosine(34) galactosyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0006400 tRNA modification;GO:0002099 tRNA wobble guanine modification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6GV29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P6S9-1", "uniprot_id": "ENTP5_RAT", "mass": 47373.0, "length": 427, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 5", "gene_name": "Entpd5", "organism": "Rat", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 5 precursor", "refseq_ac": "NP_955426", "gene_names_uniprotkb": "Entpd5", "gene_names_refseq": "Entpd5; Pcph", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 5; 3.6.1.6; GDPase ENTPD5; Guanosine-diphosphatase ENTPD5; NTPDase 5; UDPase ENTPD5; Uridine-diphosphatase ENTPD5", "protein_names_refseq": "GDPase ENTPD5; NTPDase 5; UDPase ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 precursor; guanosine-diphosphatase ENTPD5; uridine-diphosphatase ENTPD5", "tax_id": 10116, "disease": "", "pathway": " (rno:314312); (R-RNO-8850843)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11933075;27832996", "class_list": "", "function": "Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (By similarity). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER., [UniProtKB, UniProtKB, UniProtKB]; Quercetin decreases NTPDase, 5'-nucleotidase and adenosine deaminase activities in blood platelets of hypothyroid rats, and improves the oxidative profile to reduce platelet aggregation., [RefSeq, PubMed]; The expression of of PCPH in benign and malignant mammary tumors (PCPH), [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.1.5;3.6.1.62;3.6.1.64;3.1.3.1;3.9.1.1;3.6.1.16;3.6.1.53;3.6.1.6", "go_molecular_function": "GO:0004382 GDP phosphatase activity;GO:0043262 ADP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:1990003 IDP phosphatase activity;GO:0036384 CDP phosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006256 UDP catabolic process;GO:0006487 protein N-linked glycosylation;GO:0006011 UDP-alpha-D-glucose metabolic process;GO:0051084 'de novo' post-translational protein folding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P6S9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P4Z9-1", "uniprot_id": "CSN8_RAT", "mass": 23236.0, "length": 209, "protein_name": "COP9 signalosome complex subunit 8", "gene_name": "Cops8", "organism": "Rat", "refseq_name": "COP9 signalosome complex subunit 8", "refseq_ac": "NP_001013245", "gene_names_uniprotkb": "Cops8; Csn8", "gene_names_refseq": "Cops8", "protein_names_uniprotkb": "COP9 signalosome complex subunit 8; COP9 homolog; JAB1-containing signalosome subunit 8; SGN8; Signalosome subunit 8", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 8; COP9 homolog; COP9 signalosome complex subunit 8; JAB1-containing signalosome subunit 8; SGN8; signalosome subunit 8", "tax_id": 10116, "disease": "", "pathway": " (rno:363283); (R-RNO-5696394); (R-RNO-6781823); (R-RNO-8856825); (R-RNO-8951664)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0007250 activation of NF-kappaB-inducing kinase activity;GO:0010387 COP9 signalosome assembly;GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P4Z9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63184-1", "uniprot_id": "E2AK2_RAT", "mass": 58259.0, "length": 513, "protein_name": "Interferon-induced, double-stranded RNA-activated protein kinase", "gene_name": "Eif2ak2", "organism": "Rat", "refseq_name": "interferon-induced, double-stranded RNA-activated protein kinase", "refseq_ac": "NP_062208", "gene_names_uniprotkb": "Eif2ak2; Prkr", "gene_names_refseq": "Eif2ak2; Pkr; Prkr", "protein_names_uniprotkb": "Interferon-induced, double-stranded RNA-activated protein kinase; 2.7.10.2; 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 2; Interferon-inducible RNA-dependent protein kinase; PKR; Protein kinase RNA-activated; Protein kinase R; Tyrosine-protein kinase EIF2AK2; eIF-2A protein kinase 2", "protein_names_refseq": "Protein kinase, interferon-inducible double stranded RNA dependent; eIF-2A protein kinase 2; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible RNA-dependent protein kinase; protein kinase RNA-activated; tyrosine-protein kinase EIF2AK2", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); dystonia 33 (Disease Ontology:DOID:0060940); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Huntington's disease (Disease Ontology:DOID:12858); familial hypercholesterolemia (Disease Ontology:DOID:13810); Parkinson's disease (Disease Ontology:DOID:14330); hepatitis B (Disease Ontology:DOID:2043); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:54287); (R-RNO-1169408); (R-RNO-9833482)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10684936;30259999;32251680;32304741;7948027", "class_list": "", "function": "IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (By similarity). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (By similarity). Exerts its antiviral activity on a wide range of DNA and RNA viruses (By similarity). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3 and IRS1 (By similarity). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (By similarity). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (By similarity). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (By similarity). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (By similarity). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (By similarity). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (By similarity). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Regulation of the cerebrovascular smooth muscle cell phenotype by mitochondrial oxidative injury and endoplasmic reticulum stress in simulated microgravity rats via the PERK-eIF2alpha-ATF4-CHOP pathway., [RefSeq, PubMed]; Tudy reports, for the first time, that PKR-mediated harmful effects of PA in cultured cardiomyocytes via activation of JNK, NF-kB, and NLRP3 pathways. Inhibition of PKR is one of the possible mechanistic approaches to inhibit inflammation, oxidative stress, and apoptosis in lipotoxicity-induced cardiomyocyte damage., [RefSeq, PubMed]; Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.10.1;2.7.1.153;2.7.1.137;2.7.10.2;3.6.4.13;2.7.11.24;2.3.2.31;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.3.2.23;2.7.11.12;2.7.11.26;2.3.2.27;2.7.11.34;2.7.1.150;2.7.11.13;6.3.2.n3;4.1.1.32;2.7.11.10;3.1.4.11;2.7.11.19;2.7.2.3;2.7.11.11;2.7.10.4;3.1.3.48;2.7.11.31;3.5.4.37;3.1.3.16;3.6.4.10;3.6.5.-;2.7.11.4;2.3.1.48;2.7.1.32;2.7.1.82;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.7.1.91;2.3.1.-;2.4.99.18", "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1900225 regulation of NLRP3 inflammasome complex assembly;GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63184-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923J6-1", "uniprot_id": "DYH12_RAT", "mass": 357248.0, "length": 3092, "protein_name": "Dynein axonemal heavy chain 12", "gene_name": "Dnah12", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dnah12", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal heavy chain 12; Bm259", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11489260", "class_list": "", "function": "Involved in spermiogenesis. Plays a role in the proper organization of axoneme in sperm flagella, but not in cilia, by recruiting DNAH1 and DNALI1 to flagellum., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0036156 inner dynein arm;GO:0097729 9+2 motile cilium;GO:0005930 axoneme", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0007286 spermatid development;GO:0007288 sperm axoneme assembly;GO:0007018 microtubule-based movement;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q923J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1Z1-1", "uniprot_id": "E2AK3_RAT", "mass": 124770.0, "length": 1108, "protein_name": "Eukaryotic translation initiation factor 2-alpha kinase 3", "gene_name": "Eif2ak3", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 2-alpha kinase 3 precursor", "refseq_ac": "NP_113787", "gene_names_uniprotkb": "Eif2ak3; Pek; Perk", "gene_names_refseq": "Eif2ak3; PEK", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2-alpha kinase 3; 2.7.10.2; 2.7.11.1; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; Protein tyrosine kinase EIF2AK3", "protein_names_refseq": "PRKR-like endoplasmic reticulum kinase; eukaryotic translation initiation factor 2-alpha kinase 3 precursor; pancreatic eIF2-alpha kinase; protein tyrosine kinase EIF2AK3", "tax_id": 10116, "disease": "Wolcott-Rallison syndrome (Disease Ontology:DOID:0090060); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:29702); (R-RNO-381042)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10026192;10854322;32304741;33635524;35315506;9819435", "class_list": "", "function": "Changes in UPR-PERK pathway and muscle hypertrophy following resistance training and creatine supplementation in rats., [RefSeq, PubMed]; HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway., [RefSeq, PubMed]; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (PubMed:9819435). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (By similarity). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (By similarity). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (By similarity). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity). Involved in control of mitochondrial morphology and function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Regulation of the cerebrovascular smooth muscle cell phenotype by mitochondrial oxidative injury and endoplasmic reticulum stress in simulated microgravity rats via the PERK-eIF2alpha-ATF4-CHOP pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.10.1;2.7.1.153;2.7.1.137;2.7.10.2;2.7.11.24;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.19;2.7.2.3;2.7.11.11;2.7.10.4;2.7.11.31;3.1.3.16;3.6.5.3;2.7.11.4;2.3.1.48;2.7.1.32;2.7.1.82;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.4.19.12;2.7.11.39;2.4.99.18;2.7.11.10", "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070417 cellular response to cold;GO:1903788 positive regulation of glutathione biosynthetic process;GO:0032055 negative regulation of translation in response to stress;GO:0001525 angiogenesis;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z1Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHM1-1", "uniprot_id": "AQP11_RAT", "mass": 30369.0, "length": 271, "protein_name": "Aquaporin-11", "gene_name": "Aqp11", "organism": "Rat", "refseq_name": "aquaporin-11", "refseq_ac": "NP_775128", "gene_names_uniprotkb": "Aqp11", "gene_names_refseq": "Aqp11", "protein_names_uniprotkb": "Aquaporin-11; AQP-11", "protein_names_refseq": "AQP-11; aquaporin-11", "tax_id": 10116, "disease": "", "pathway": " (rno:286758); (R-RNO-432047)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16650285;19812234;27107718;30337368;38511591", "class_list": "", "function": "AQP11 has a unique distribution in brain: Purkinje cell dendrites, CA1 & CA2 neurons, & cerebral cortical neurons. It is functionally distinct from other proteins of the aquaporin superfamily and could represent a new aquaporin subfamily. Publication Status: Online-Only, [RefSeq, PubMed]; Application of exogenous miR-27a-3p may protect against post-ICH complications by targeting AQP11 in the capillary endothelial cells of the brain., [RefSeq, PubMed]; Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (By similarity). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Expression of AQP-10, -11 and -12 in the rat stria vascularis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AZ79", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0015267 channel activity;GO:0015250 water channel activity;GO:0015254 glycerol channel activity;GO:0140070 hydrogen peroxide channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0051260 protein homooligomerization;GO:0001822 kidney development;GO:0006612 protein targeting to membrane;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CHM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920P6-1", "uniprot_id": "ADA_RAT", "mass": 39899.0, "length": 352, "protein_name": "Adenosine deaminase", "gene_name": "Ada", "organism": "Rat", "refseq_name": "adenosine deaminase", "refseq_ac": "NP_569083", "gene_names_uniprotkb": "Ada", "gene_names_refseq": "Ada", "protein_names_uniprotkb": "Adenosine deaminase; 3.5.4.4; Adenosine aminohydrolase", "protein_names_refseq": "adenosine aminohydrolase; adenosine deaminase", "tax_id": 10116, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); trypanosomiasis (Disease Ontology:DOID:10113); Legionnaires' disease (Disease Ontology:DOID:10457); stomach cancer (Disease Ontology:DOID:10534); pleural tuberculosis (Disease Ontology:DOID:106); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); Q fever (Disease Ontology:DOID:11100); pulmonary edema (Disease Ontology:DOID:11396); familial hyperlipidemia (Disease Ontology:DOID:1168); uterine fibroid (Disease Ontology:DOID:13223); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); pulmonary sarcoidosis (Disease Ontology:DOID:13406); sporotrichosis (Disease Ontology:DOID:14484); malignant mesothelioma (Disease Ontology:DOID:1790); colon cancer (Disease Ontology:DOID:219); leptospirosis (Disease Ontology:DOID:2297); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); pulmonary tuberculosis (Disease Ontology:DOID:2957); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); adenosine deaminase deficiency (Disease Ontology:DOID:5810); severe combined immunodeficiency (Disease Ontology:DOID:627); peritonitis (Disease Ontology:DOID:8283); lung disease (Disease Ontology:DOID:850); oral cavity cancer (Disease Ontology:DOID:8618); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24165); (R-RNO-74217); (R-RNO-9755088)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "19900420;27832996;8783262", "class_list": "", "function": "Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:19900420). Plays an important role in purine metabolism and in adenosine homeostasis (By similarity). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity). Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (By similarity) (PubMed:19900420). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Quercetin decreases NTPDase, 5'-nucleotidase and adenosine deaminase activities in blood platelets of hypothyroid rats, and improves the oxidative profile to reduce platelet aggregation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.4.4;2.4.2.1;2.4.2.28", "go_molecular_function": "GO:0004000 adenosine deaminase activity;GO:0008270 zinc ion binding;GO:0001883 purine nucleoside binding;GO:0019239 deaminase activity;GO:0046936 2'-deoxyadenosine deaminase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0033081 regulation of T cell differentiation in thymus;GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:1903576 response to L-arginine;GO:0001701 in utero embryonic development;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q920P6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63086-1", "uniprot_id": "CTF1_RAT", "mass": 21439.0, "length": 203, "protein_name": "Cardiotrophin-1", "gene_name": "Ctf1", "organism": "Rat", "refseq_name": "cardiotrophin-1", "refseq_ac": "NP_058825", "gene_names_uniprotkb": "Ctf1", "gene_names_refseq": "Ctf1", "protein_names_uniprotkb": "Cardiotrophin-1; CT-1", "protein_names_refseq": "CT-1; cardiotrophin-1", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); isolated growth hormone deficiency type II (Disease Ontology:DOID:0060872); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:29201); (R-RNO-6788467)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11448959;11932952;12027405;22733458;22787135;23064267;23277190;8604995", "class_list": "", "function": "CT-1 signals through p38, ERK, and Akt in a parallel manner to activate NF-kappa B and that NF-kappa B is required for CT-1 to mediate its full cytoprotective effects in cardiac myocytes., [RefSeq, PubMed]; CT1 has a role in hypertrophy of rat cardiomyocytes as measured by an increase in cell area and enhanced protein: DNA ratio, [RefSeq, PubMed]; Cardiomyocytes treated with CT-1 present high spontaneous Ca(2+) release during diastole, a mechanism linked to arrhythmogenicity in the pathologic heart., [RefSeq, PubMed]; Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction., [RefSeq, PubMed]; Cardiotrophin-1 modulates glucose transport in cardiomyocytes positively or negatively depending on its concentration., [RefSeq, PubMed]; Cardiotrophin-1 promotes the outgrowth of embryonic cranial motor neurons in isolated stage E12 hindbrain explants., [RefSeq, PubMed]; Functions as a cytokine that binds to the LIF receptor complex (By similarity). The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (By similarity). Functionnally, acts as a potent cardiac survival factor, and promotes cardiomyocyte proliferation and hypertrophy (By similarity). Mechanistically, ligand binding to LIFR, induces heterodimerization with IL6ST/gp130 activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activator of transcription STAT3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; In the chronic kidney disease-cardiac hypertrophy model exercise rescues cardiac disease via cardiotrophin-1/LIFR/gp 130/JAK/STAT3 pathway., [RefSeq, PubMed]; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005146 leukemia inhibitory factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006955 immune response;GO:0007399 nervous system development;GO:0048666 neuron development;GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein;GO:0007259 cell surface receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63086-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIC8-1", "uniprot_id": "ALKB3_RAT", "mass": 34011.0, "length": 295, "protein_name": "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3", "gene_name": "Alkbh3", "organism": "Rat", "refseq_name": "alpha-ketoglutarate-dependent dioxygenase alkB homolog 3", "refseq_ac": "NP_001014202", "gene_names_uniprotkb": "Alkbh3; Abh3", "gene_names_refseq": "Alkbh3", "protein_names_uniprotkb": "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; 1.14.11.33; 1.14.11.54; Alkylated DNA repair protein alkB homolog 3", "protein_names_refseq": "alkB, alkylation repair homolog 3; alkylated DNA repair protein alkB homolog 3; alkylation repair-like protein 3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3", "tax_id": 10116, "disease": "", "pathway": " (rno:362169)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.33;1.14.11.51;4.2.99.18;1.14.11.54", "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0051747 cytosine C-5 DNA demethylase activity;GO:1990930 mRNA N1-methyladenosine dioxygenase activity;GO:0035515 oxidative RNA demethylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0008283 cell population proliferation;GO:0006307 DNA alkylation repair;GO:2000766 negative regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGS4-1", "uniprot_id": "CHMP3_RAT", "mass": 25062.0, "length": 223, "protein_name": "Charged multivesicular body protein 3", "gene_name": "Chmp3", "organism": "Rat", "refseq_name": "charged multivesicular body protein 3", "refseq_ac": "NP_758834", "gene_names_uniprotkb": "Chmp3; Vps24", "gene_names_refseq": "Chmp3; Vps24", "protein_names_uniprotkb": "Charged multivesicular body protein 3; Chromatin-modifying protein 3; Vacuolar protein sorting-associated protein 24; rVps24p", "protein_names_refseq": "Vps24p protein; charged multivesicular body protein 3; chromatin-modifying protein 3; rVps24p; vacuolar protein sorting 24 homolog; vacuolar protein sorting-associated protein 24", "tax_id": 10116, "disease": "", "pathway": " (rno:282834); (R-RNO-1632852); (R-RNO-5620971); (R-RNO-917729); (R-RNO-9668328)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "12878588;22673903", "class_list": "", "function": "Characterization of mVps24p; findings show it is selective in its binding to PtdIns(3,5)P2, [RefSeq, PubMed]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0031210 phosphatidylcholine binding;GO:1990381 ubiquitin-specific protease binding;GO:0140678 molecular function inhibitor activity;GO:0180020 membrane bending activity", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0005643 nuclear pore;GO:0005769 early endosome", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0039702 viral budding via host ESCRT complex;GO:0061763 multivesicular body-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CGS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHL3-1", "uniprot_id": "ECEL1_RAT", "mass": 87944.0, "length": 775, "protein_name": "Endothelin-converting enzyme-like 1", "gene_name": "Ecel1", "organism": "Rat", "refseq_name": "endothelin-converting enzyme-like 1", "refseq_ac": "NP_068544", "gene_names_uniprotkb": "Ecel1; Dine; Xce", "gene_names_refseq": "Dine; Ecel1", "protein_names_uniprotkb": "Endothelin-converting enzyme-like 1; 3.4.24.-; Damage-induced neuronal endopeptidase; Xce protein", "protein_names_refseq": "damage-induced neuronal endopeptidase; endothelin-converting enzyme-like 1; metallopeptidase; xce protein", "tax_id": 10116, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); distal arthrogryposis type 5D (Disease Ontology:DOID:0111594)", "pathway": " (rno:60417)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10759559;12417666;16675137;18192274;9931490", "class_list": "", "function": "DINE gene expression is regulated separately by both LIF and NGF deprivation, and this regulation pattern is similar to that of galanin gene expression after nerve injury, [RefSeq, PubMed]; Damage-induced neuronal endopeptidase play an important role in embryonic neural development, in particular in peripheral ganglia derived from the neural crest, and in some neurons from the basal plate such as the hypothalamus and cranial motor neurons., [RefSeq, PubMed]; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. Cleaves the synthetic substrate Z-Gly-Gly-Leu-pNA and releases pNA. May protect against C2-ceramide-induced apoptosis., [UniProtKB]; Sp1 recruits ATF3, c-Jun, and STAT3 to obtain the requisite synergistic effect in neuronal injury through DINE neuronal injury-inducible gene, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z192", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0003016 respiratory system process;GO:0007218 neuropeptide signaling pathway;GO:0016485 protein processing;GO:0035556 intracellular signal transduction;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JHL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZK8-1", "uniprot_id": "DNS2A_RAT", "mass": 38175.0, "length": 350, "protein_name": "Deoxyribonuclease-2-alpha", "gene_name": "Dnase2", "organism": "Rat", "refseq_name": "deoxyribonuclease-2-alpha precursor", "refseq_ac": "NP_612548", "gene_names_uniprotkb": "Dnase2; Dnase2a; Dnl2", "gene_names_refseq": "Dnase2a; Dnase2", "protein_names_uniprotkb": "Deoxyribonuclease-2-alpha; 3.1.22.1; Acid DNase; DNase II alpha; Deoxyribonuclease II alpha; Lysosomal DNase II", "protein_names_refseq": "DNase II alpha; acid DNase; deoxyribonuclease II alpha; deoxyribonuclease II, lysosomal; deoxyribonuclease-2-alpha precursor; deoxyribonuclease-2-alpha; lysosomal DNase II", "tax_id": 10116, "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:171575); (R-RNO-432720)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10558878;25781645", "class_list": "", "function": "Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PKC zeta interacts with LEI/L-DNase II and controls its DNase activity by impairing its nuclear translocation., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKC7", "ec_number_list": "5.3.4.1;2.3.1.-;3.6.5.5;3.6.4.10;3.6.5.2;3.1.22.1;3.4.18.1", "go_molecular_function": "GO:0004520 DNA endonuclease activity;GO:0004531 deoxyribonuclease II activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0043277 apoptotic cell clearance;GO:0006309 apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHF5-1", "uniprot_id": "CISY_RAT", "mass": 51867.0, "length": 466, "protein_name": "Citrate synthase, mitochondrial", "gene_name": "Cs", "organism": "Rat", "refseq_name": "citrate synthase, mitochondrial precursor", "refseq_ac": "NP_570111", "gene_names_uniprotkb": "Cs", "gene_names_refseq": "Cs", "protein_names_uniprotkb": "Citrate synthase, mitochondrial; 2.3.3.1; Citrate (Si)-synthase", "protein_names_refseq": "citrate (Si)-synthase; citrate synthase, mitochondrial precursor; citrate synthase, mitochondrial", "tax_id": 10116, "disease": "limb ischemia (Disease Ontology:DOID:0050852); left ventricular failure (Disease Ontology:DOID:0051064); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypothyroidism (Disease Ontology:DOID:1459); bipolar disorder (Disease Ontology:DOID:3312); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:170587); (R-RNO-71403); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "19423663;26446791;34350838;34502162", "class_list": "", "function": "Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The effects of exercise on skeletal and heart muscle citrate synthase and carnitine palmitoyltransferase mRNA expressions in high-calorie fed rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.5;1.3.8.5;6.2.1.4;4.98.1.1;5.6.2.3;2.8.3.5;2.3.1.-;2.3.1.41;3.4.21.92;3.5.3.1;3.1.2.2;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.2.-;1.1.1.37;6.4.1.3;7.1.2.2;1.4.1.3;1.2.1.3;2.3.1.37;4.2.1.2;2.3.1.9;2.3.3.10;5.3.3.8;1.1.1.30;3.6.4.10;1.2.4.1;1.1.1.42;5.6.1.7;1.3.8.1;2.7.1.23;1.2.4.2;5.3.3.21;2.7.11.2;2.7.11.-;7.1.1.2;1.2.1.36;1.7.1.-;1.2.1.28;1.8.1.4;2.3.3.1;3.4.21.53;1.1.1.41;4.2.1.3", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer;GO:0036440 citrate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006101 citrate metabolic process;GO:0007507 heart development;GO:0005975 carbohydrate metabolic process;GO:0006084 acetyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VHF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63164-1", "uniprot_id": "DYH1_RAT", "mass": 515021.0, "length": 4516, "protein_name": "Dynein axonemal heavy chain 1", "gene_name": "Dnah1", "organism": "Rat", "refseq_name": "dynein axonemal heavy chain 1", "refseq_ac": "NP_001028827", "gene_names_uniprotkb": "Dnah1; Dlp1", "gene_names_refseq": "Dnah1; Dnahc1; RGD1311110", "protein_names_uniprotkb": "Dynein axonemal heavy chain 1; Axonemal beta dynein heavy chain 1; Ciliary dynein heavy chain 1", "protein_names_refseq": "axonemal beta dynein heavy chain 1; ciliary dynein heavy chain 1; dynein axonemal heavy chain 1; dynein heavy chain 1, axonemal; dynein, axonemal, heavy polypeptide 1", "tax_id": 10116, "disease": "spermatogenic failure 18 (Disease Ontology:DOID:0070165); primary ciliary dyskinesia 37 (Disease Ontology:DOID:0080266)", "pathway": " (rno:171339)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7657712", "class_list": "", "function": "Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0030286 dynein complex", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0007288 sperm axoneme assembly;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FT5-1", "uniprot_id": "BHMT2_RAT", "mass": 39929.0, "length": 363, "protein_name": "S-methylmethionine--homocysteine S-methyltransferase BHMT2", "gene_name": "Bhmt2", "organism": "Rat", "refseq_name": "S-methylmethionine--homocysteine S-methyltransferase BHMT2", "refseq_ac": "NP_001014278", "gene_names_uniprotkb": "Bhmt2", "gene_names_refseq": "Bhmt2", "protein_names_uniprotkb": "S-methylmethionine--homocysteine S-methyltransferase BHMT2; 2.1.1.10; Betaine--homocysteine S-methyltransferase 2; SMM-hcy methyltransferase", "protein_names_refseq": "S-methylmethionine--homocysteine S-methyltransferase BHMT2; SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:365972); (R-RNO-1614635)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29804940", "class_list": "", "function": "Involved in the regulation of homocysteine metabolism., [UniProtKB, UniProtKB, UniProtKB]; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity)., [UniProtKB]; These findings indicate that decreased liver Bhmt and Cbs-mediated homocysteine metabolism might have a role in hyperhomocysteinemia in polycystic ovary syndrome and provides further evidence for a potential role of decreased liver function in PCOS., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.10", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061627 S-methylmethionine-homocysteine S-methyltransferase activity;GO:0008172 S-methyltransferase activity;GO:0047150 betaine-homocysteine S-methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0032259 methylation;GO:0033477 S-methylmethionine metabolic process;GO:0046500 S-adenosylmethionine metabolic process;GO:0071267 L-methionine salvage;GO:0009086 methionine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZPG5-1", "uniprot_id": "UBP30_RAT", "mass": 58206.0, "length": 517, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 30", "gene_name": "Usp30", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 30", "refseq_ac": "NP_001100623", "gene_names_uniprotkb": "Usp30", "gene_names_refseq": "Usp30", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 30; 3.4.19.12; Deubiquitinating enzyme 30; Ub-specific protease 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30", "protein_names_refseq": "deubiquitinating enzyme 30; ub-specific protease 30; ubiquitin carboxyl-terminal hydrolase 30; ubiquitin specific protease 30; ubiquitin thioesterase 30; ubiquitin-specific-processing protease 30", "tax_id": 10116, "disease": "", "pathway": " (rno:304579); (R-RNO-5689880); (R-RNO-9664873)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "24896179", "class_list": "", "function": "Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:24896179). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (By similarity). Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;3.4.19.12;2.3.2.27;3.4.24.56;5.2.1.8", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZPG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1L1K1-1", "uniprot_id": "PRR5L_RAT", "mass": 41162.0, "length": 370, "protein_name": "Proline-rich protein 5-like", "gene_name": "Prr5l", "organism": "Rat", "refseq_name": "proline-rich protein 5-like", "refseq_ac": "NP_001073619", "gene_names_uniprotkb": "Prr5l; Protor2", "gene_names_refseq": "Protor-2; Protor2; Prr5l; RGD1309969", "protein_names_uniprotkb": "Proline-rich protein 5-like; Protein observed with Rictor-2; Protor-2", "protein_names_refseq": "proline-rich protein 5-like; protein observed with Rictor-2", "tax_id": 10116, "disease": "", "pathway": " (rno:362171)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration. Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF and GM-CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0031932 TORC2 complex", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0001934 positive regulation of protein phosphorylation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0090316 positive regulation of intracellular protein transport;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L1K1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5DEN9-1", "uniprot_id": "VPS28_RAT", "mass": 26110.0, "length": 228, "protein_name": "Vacuolar protein sorting-associated protein 28 homolog", "gene_name": "Vps28", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Vps28", "gene_names_refseq": "", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 28 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:300052); (R-RNO-917729)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Component of the endosomal sorting complex required for transport-I (ESCRT-I) complex, a regulator of vesicular trafficking process. The ESCRT-I complex participates in the sorting of membrane proteins into vesicles that bud into late endosomal compartments called multivesicular bodies, and is also involved in the budding of many viruses., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:2000397 positive regulation of ubiquitin-dependent endocytosis;GO:0045732 positive regulation of protein catabolic process;GO:0031397 negative regulation of protein ubiquitination;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DEN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXM9-1", "uniprot_id": "RLIG1_RAT", "mass": 37305.0, "length": 325, "protein_name": "RNA ligase 1", "gene_name": "Rlig1", "organism": "Rat", "refseq_name": "RNA ligase 1", "refseq_ac": "NP_001014105", "gene_names_uniprotkb": "Rlig1; RGD1307947", "gene_names_refseq": "RGD1307947; Rlig1; Rnl", "protein_names_uniprotkb": "RNA ligase 1; 6.5.1.3; RNA ligase; Rnl", "protein_names_refseq": "RNA ligase 1; RNA ligase; uncharacterized protein C12orf29 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:314788)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as an RNA ligase, in vitro. The ligation reaction entails three nucleotidyl transfer steps. In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate. In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate. In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP. Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids. May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0003972 RNA ligase (ATP) activity", "go_cellular_component": "", "go_biological_process": "GO:0000302 response to reactive oxygen species;GO:0042245 RNA repair;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2U0-1", "uniprot_id": "CLPX_RAT", "mass": 69208.0, "length": 633, "protein_name": "ATP-dependent clpX-like chaperone, mitochondrial", "gene_name": "Clpx", "organism": "Rat", "refseq_name": "ATP-dependent clpX-like chaperone, mitochondrial precursor", "refseq_ac": "NP_001007804", "gene_names_uniprotkb": "Clpx", "gene_names_refseq": "Clpx", "protein_names_uniprotkb": "ATP-dependent clpX-like chaperone, mitochondrial; 3.6.4.10; ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial; Caseinolytic mitochondrial matrix peptidase chaperone subunit X", "protein_names_refseq": "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial; ATP-dependent clpX-like chaperone, mitochondrial precursor; ATP-dependent clpX-like chaperone, mitochondrial; ClpX caseinolytic peptidase X homolog; ClpX caseinolytic protease X homolog; caseinolytic peptidase X; caseinolytic protease X", "tax_id": 10116, "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270)", "pathway": " (rno:300786); (R-RNO-9837999)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation. Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;1.3.8.5;3.6.4.10;3.6.4.-;6.2.1.4;2.3.2.27;4.98.1.1;5.6.2.4;3.6.5.-;2.8.3.5;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;2.3.1.41;3.4.21.92;3.5.3.1;3.1.2.2;3.1.2.-;1.1.1.37;3.1.3.1;3.9.1.1;7.1.2.2;1.2.1.3;2.3.1.37;4.2.1.2;6.1.1.12;2.3.1.9;5.3.3.8;3.6.1.-;1.1.1.30;1.2.4.1;1.1.1.42;5.6.1.7;2.7.4.3;1.2.4.2;5.3.3.21;2.7.11.2;2.7.11.-;3.1.4.-;7.1.1.2;1.2.1.36;1.7.1.-;1.2.1.28;1.8.1.4;3.4.24.-;3.6.-.-;2.3.3.1;3.4.21.53;1.1.1.41;5.6.2.5;4.2.1.3;1.1.1.35", "go_molecular_function": "GO:0005524 ATP binding;GO:0016504 peptidase activator activity;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0009368 endopeptidase Clp complex;GO:0009841 mitochondrial endopeptidase Clp complex", "go_biological_process": "GO:0006508 proteolysis;GO:0046034 ATP metabolic process;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1LMZ8-1", "uniprot_id": "PSD11_RAT", "mass": 47464.0, "length": 422, "protein_name": "26S proteasome non-ATPase regulatory subunit 11", "gene_name": "Psmd11", "organism": "Rat", "refseq_name": "26S proteasome non-ATPase regulatory subunit 11", "refseq_ac": "NP_001380935", "gene_names_uniprotkb": "Psmd11", "gene_names_refseq": "Psmd11", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit RPN6", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit RPN6; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (rno:303353); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-6798695); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 57, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex", "go_biological_process": "GO:0048863 stem cell differentiation;GO:0010498 proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0043248 proteasome assembly;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LMZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A666-1", "uniprot_id": "UBN2_RAT", "mass": 143640.0, "length": 1330, "protein_name": "Ubinuclein-2", "gene_name": "Ubn2", "organism": "Rat", "refseq_name": "ubinuclein-2", "refseq_ac": "NP_001128025", "gene_names_uniprotkb": "Ubn2", "gene_names_refseq": "RGD1310722; Ubn2", "protein_names_uniprotkb": "Ubinuclein-2", "protein_names_refseq": "ubinuclein-2", "tax_id": 10116, "disease": "", "pathway": " (rno:312248)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000417 HIR complex", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A666-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZYP5-1", "uniprot_id": "TM35B_RAT", "mass": 16396.0, "length": 152, "protein_name": "Transmembrane protein 35B", "gene_name": "Tmem35b", "organism": "Rat", "refseq_name": "transmembrane protein 35B precursor", "refseq_ac": "NP_001258066", "gene_names_uniprotkb": "Tmem35b; Zmym6nb", "gene_names_refseq": "Tmem35b; Zmym6nb", "protein_names_uniprotkb": "Transmembrane protein 35B; ZMYM6 neighbor protein", "protein_names_refseq": "ZMYM6 neighbor protein; transmembrane protein 35B precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:100361631)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZYP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JK79-1", "uniprot_id": "CKLF_RAT", "mass": 16855.0, "length": 151, "protein_name": "Chemokine-like factor", "gene_name": "Cklf", "organism": "Rat", "refseq_name": "chemokine-like factor", "refseq_ac": "NP_620811", "gene_names_uniprotkb": "Cklf; Cklf1", "gene_names_refseq": "Cklf1; Cklf", "protein_names_uniprotkb": "Chemokine-like factor", "protein_names_refseq": "chemokine-like factor 1; chemokine-like factor", "tax_id": 10116, "disease": "", "pathway": " (rno:245978)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12706894;21964493;23203409;27283776;31387172;32446198;33578361;34385606", "class_list": "", "function": "CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia., [RefSeq, PubMed]; Chemokine-like factor 1 (CKLF1) is involved in blood-brain barrier disruption after reperfusion. Inhibition of CKLF1 protects against cerebral ischemia by maintaining BBB integrity, possibly via inhibiting the expression of aquaporin-4 and matrix metalloproteinase-9, and increasing the expression of tight junction protein., [RefSeq, PubMed]; Has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:12706894). Binds CCR4 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Inhibition of CKLF1 ameliorates hepatic ischemia-reperfusion injury via MAPK pathway., [RefSeq, PubMed]; May play an important role in inflammation and regeneration of skeletal muscle (By similarity). Essential for embryonic development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke., [RefSeq, PubMed]; New treatment strategies to limit restenosis based on CKLF1 as a future target., [RefSeq, PubMed]; These data suggest that CKLF1 has a pivotal role in intimal hyperplasia by mediating VSMC migration. C19 was demonstrated to inhibit CKLF1-mediatated chemotaxis, [RefSeq, PubMed]; This study demonstrated that the expression of CKLF1 increases after focal cerebral ischemia in rat brain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JK80", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0032940 secretion by cell;GO:0048247 lymphocyte chemotaxis;GO:0048246 macrophage chemotaxis;GO:0030593 neutrophil chemotaxis;GO:0030595 leukocyte chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JK79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5DF45-1", "uniprot_id": "TRAF6_RAT", "mass": 60253.0, "length": 530, "protein_name": "TNF receptor-associated factor 6", "gene_name": "Traf6", "organism": "Rat", "refseq_name": "TNF receptor-associated factor 6", "refseq_ac": "NP_001101224", "gene_names_uniprotkb": "Traf6", "gene_names_refseq": "Traf6", "protein_names_uniprotkb": "TNF receptor-associated factor 6; 2.3.2.27; E3 ubiquitin-protein ligase TRAF6; RING-type E3 ubiquitin transferase TRAF6", "protein_names_refseq": "E3 ubiquitin-protein ligase TRAF6; RING-type E3 ubiquitin transferase TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase; TNF receptor-associated factor 6", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); hypohidrotic ectodermal dysplasia (Disease Ontology:DOID:14793); laryngeal carcinoma (Disease Ontology:DOID:2600)", "pathway": " (rno:311245); (R-RNO-1257604); (R-RNO-166058); (R-RNO-168638); (R-RNO-193692); (R-RNO-202424); (R-RNO-205043); (R-RNO-209543); (R-RNO-209560); (R-RNO-2871837); (R-RNO-445989); (R-RNO-450302); (R-RNO-450321); (R-RNO-5607764); (R-RNO-5689880); (R-RNO-5689896); (R-RNO-6811558); (R-RNO-9020702); (R-RNO-937039); (R-RNO-937041); (R-RNO-937042); (R-RNO-937072); (R-RNO-9645460); (R-RNO-975138); (R-RNO-975144); (R-RNO-975163); (R-RNO-9758274); (R-RNO-975871)", "pathway_count": 28, "publication_count": 6, "publication_id_list": "29393594;35217880;35405432;35932799;37165439;37898386", "class_list": "", "function": "Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner., [RefSeq, PubMed]; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN (By similarity). Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (By similarity). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by initiating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: TRAF6 catalyzes initial 'Lys-63'-linked-polyubiquitin chains that are then branched via 'Lys-48'-linked polyubiquitin by HUWE1. 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination. Also participates in the TCR signaling by ubiquitinating LAT (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Effect of TRAF6 in acute pancreatitis-induced intestinal barrier injury via TLR4/NF-kappaB signal pathway., [RefSeq, PubMed]; Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models. Publication Status: Online-Only, [RefSeq, PubMed]; M6A methyltransferase METTL3 contributes to sympathetic hyperactivity post-MI via promoting TRAF6-dependent mitochondrial ROS production., [RefSeq, PubMed]; Mechanism of CREB1 in cardiac function of rats with heart failure via regulating the microRNA-376a-3p/TRAF6 axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.11.1;2.7.1.153;2.7.1.137;2.3.2.27;2.3.2.26;2.7.1.154;4.2.1.1;3.4.19.12;2.7.12.2;2.3.2.24;2.3.2.23;3.2.2.-;3.2.2.6;2.7.11.13;3.6.5.2;2.7.10.2;2.7.11.10;3.4.23.-;2.7.11.25;3.1.3.48;3.2.1.31", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042826 histone deacetylase binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:1904385 cellular response to angiotensin;GO:0070498 interleukin-1-mediated signaling pathway;GO:0002637 regulation of immunoglobulin production;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B5DF45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RYF7-1", "uniprot_id": "WASH1_RAT", "mass": 51327.0, "length": 475, "protein_name": "WASH complex subunit 1", "gene_name": "Washc1", "organism": "Rat", "refseq_name": "WASH complex subunit 1", "refseq_ac": "NP_001120862", "gene_names_uniprotkb": "Washc1; Wash1; Wash2", "gene_names_refseq": "ORF19; Wash1; Wash2; Washc1; Wash", "protein_names_uniprotkb": "WASH complex subunit 1; WAS protein family homolog 1", "protein_names_refseq": "WAS protein family homolog 1; WAS protein family homolog 2; WASH complex subunit 1", "tax_id": 10116, "disease": "", "pathway": " (rno:367328)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in cytokinesis and following polar body extrusion during oocyte meiotic maturation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0031625 ubiquitin protein ligase binding;GO:0043014 alpha-tubulin binding;GO:0043015 gamma-tubulin binding;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030027 lamellipodium", "go_biological_process": "GO:0002468 dendritic cell antigen processing and presentation;GO:1904109 positive regulation of cholesterol import;GO:0022617 extracellular matrix disassembly;GO:0030335 positive regulation of cell migration;GO:2000010 positive regulation of protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYU0-1", "uniprot_id": "CL050_RAT", "mass": 47035.0, "length": 415, "protein_name": "Uncharacterized protein C12orf50 homolog", "gene_name": "C7h12orf50", "organism": "Rat", "refseq_name": "uncharacterized protein C12orf50 homolog", "refseq_ac": "NP_001019523", "gene_names_uniprotkb": "C7h12orf50; LOC500827", "gene_names_refseq": "C7h12orf50; Zc3h11d", "protein_names_uniprotkb": "Uncharacterized protein C12orf50 homolog", "protein_names_refseq": "uncharacterized protein C12orf50 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500827)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q67EQ1-1", "uniprot_id": "CLC4E_RAT", "mass": 24911.0, "length": 215, "protein_name": "C-type lectin domain family 4 member E", "gene_name": "Clec4e", "organism": "Rat", "refseq_name": "C-type lectin domain family 4 member E", "refseq_ac": "NP_001005897", "gene_names_uniprotkb": "Clec4e; Clecsf9; Mincle", "gene_names_refseq": "Clec4e; Clecsf9; Mincle", "protein_names_uniprotkb": "C-type lectin domain family 4 member E; C-type lectin superfamily member 9; Macrophage-inducible C-type lectin; Mincle", "protein_names_refseq": "C-type lectin domain family 4 member E; C-type lectin superfamily member 9; immunoreceptor; macrophage-inducible C-type lectin", "tax_id": 10116, "disease": "", "pathway": " (rno:450223); (R-RNO-5621480)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15368084;23921530;26138128;28393919;30353660;31725411", "class_list": "", "function": "C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation., [RefSeq, PubMed]; Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 (Th1) and T-helper 17 (Th17) cell subtypes. Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation. Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue., [UniProtKB, UniProtKB]; Data suggest that therapeutic interventions targeting macrophage-inducible C-type lectin protein (Mincle protein) signalling pathway could constitute a novel approach for preventing infarction injury., [RefSeq, PubMed]; Mast cells contribute to Mincle-mediated immunity through Syk activation triggered by association with the FcepsilonRIbetagamma complex. Publication Status: Online-Only, [RefSeq, PubMed]; The Mincle signaling pathway is involved in early brain injury after subarachnoid hemorrhage., [RefSeq, PubMed]; The results presented in this paper suggest that the Mincle/MCL/FcepsilonRI-gamma complex is the functionally optimal form for these C-type lectin receptors on the surface of myeloid cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q56TZ4", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0038187 pattern recognition receptor activity;GO:0051861 glycolipid binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0002292 T cell differentiation involved in immune response;GO:0038094 Fc-gamma receptor signaling pathway;GO:0002221 pattern recognition receptor signaling pathway;GO:0006955 immune response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q67EQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RZ78-1", "uniprot_id": "VPS29_RAT", "mass": 20469.0, "length": 182, "protein_name": "Vacuolar protein sorting-associated protein 29", "gene_name": "Vps29", "organism": "Rat", "refseq_name": "vacuolar protein sorting-associated protein 29", "refseq_ac": "NP_001099402", "gene_names_uniprotkb": "Vps29", "gene_names_refseq": "Vps29", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 29; Vesicle protein sorting 29", "protein_names_refseq": "vacuolar protein sorting 29 homolog; vacuolar protein sorting-associated protein 29", "tax_id": 10116, "disease": "", "pathway": " (rno:288666); (R-RNO-3238698)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (By similarity). Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (By similarity). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (By similarity). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6J1A4", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0030906 retromer, cargo-selective complex;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005770 late endosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RZ78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1L112-1", "uniprot_id": "WDR55_RAT", "mass": 42142.0, "length": 384, "protein_name": "WD repeat-containing protein 55", "gene_name": "Ik; Wdr55", "organism": "Rat", "refseq_name": "WD repeat-containing protein 55", "refseq_ac": "NP_001017932", "gene_names_uniprotkb": "Ik; Wdr55; Ik", "gene_names_refseq": "LRRG00133; RGD1305640; Wdr55", "protein_names_uniprotkb": "WD repeat-containing protein 55", "protein_names_refseq": "WD repeat-containing protein 55", "tax_id": 10116, "disease": "", "pathway": " (rno:307494)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4A929-1", "uniprot_id": "WDR81_RAT", "mass": 212260.0, "length": 1933, "protein_name": "WD repeat-containing protein 81", "gene_name": "Wdr81", "organism": "Rat", "refseq_name": "WD repeat-containing protein 81", "refseq_ac": "NP_001127832", "gene_names_uniprotkb": "Wdr81", "gene_names_refseq": "RGD1311334; Wdr81", "protein_names_uniprotkb": "WD repeat-containing protein 81", "protein_names_refseq": "WD repeat-containing protein 81", "tax_id": 10116, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 (Disease Ontology:DOID:0070557); microcephaly (Disease Ontology:DOID:10907); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:303312)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C. May also be involved in maintenance of normal mitochondrial structure and organization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0035014 phosphatidylinositol 3-kinase regulator activity;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0045022 early endosome to late endosome transport;GO:0007005 mitochondrion organization;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0035973 aggrephagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A929-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H53-1", "uniprot_id": "CL071_RAT", "mass": 34296.0, "length": 300, "protein_name": "Uncharacterized protein C12orf71 homolog", "gene_name": "C4h12orf71", "organism": "Rat", "refseq_name": "uncharacterized protein C12orf71 homolog", "refseq_ac": "NP_001037764", "gene_names_uniprotkb": "C4h12orf71", "gene_names_refseq": "C4h12orf71", "protein_names_uniprotkb": "Uncharacterized protein C12orf71 homolog", "protein_names_refseq": "uncharacterized protein C12orf71 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:690784)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XI42-1", "uniprot_id": "AL3B1_RAT", "mass": 52147.0, "length": 468, "protein_name": "Aldehyde dehydrogenase family 3 member B1", "gene_name": "Aldh3b1; Aldh3b2l1; Aldh3b2; Aldh3b3", "organism": "Rat", "refseq_name": "aldehyde dehydrogenase family 3 member B1", "refseq_ac": "NP_001006999", "gene_names_uniprotkb": "Aldh3b1; Aldh3b2l1; Aldh3b2; Aldh3b3; Aldh3b1; Aldh3b2-ps1; Aldh3b2; Aldh3b3l-ps1; Aldh3b3; LOC120099971; LOC688778", "gene_names_refseq": "Aldh3b1", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 3 member B1; 1.2.1.28; 1.2.1.48; 1.2.1.5; 1.2.1.7; Aldehyde dehydrogenase 7; Long-chain fatty aldehyde dehydrogenase; Medium-chain fatty aldehyde dehydrogenase", "protein_names_refseq": "aldehyde dehydrogenase 7; aldehyde dehydrogenase family 3 member B1; long-chain fatty aldehyde dehydrogenase; medium-chain fatty aldehyde dehydrogenase", "tax_id": 10116, "disease": "Sjogren-Larsson syndrome (Disease Ontology:DOID:14501)", "pathway": " (rno:309147); (R-RNO-6798695); (R-RNO-9845614)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids. May have a protective role against the cytotoxicity induced by lipid peroxidation. Short-chain fatty aldehydes are not good substrates. Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;7.6.2.1;3.6.5.2;2.3.1.51;2.7.11.1;3.4.24.11;1.2.1.5;1.2.1.3;3.4.11.-;3.4.11.2;1.14.14.18;3.4.21.73;1.2.1.94;1.2.1.36;1.2.1.19;1.2.1.28;1.1.1.-;3.1.4.4;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.3.2.27;3.6.1.-;1.2.1.7;1.2.1.48;1.14.19.17;5.2.1.-;3.2.2.6;1.2.1.31;1.2.1.8;1.7.1.-;2.3.1.20;2.3.1.76;1.2.1.47;1.2.1.46", "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity;GO:0018479 benzaldehyde dehydrogenase (NAD+) activity;GO:0050061 long-chain fatty aldehyde dehydrogenase (NAD+) activity;GO:0052814 medium-chain fatty aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005811 lipid droplet", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006979 response to oxidative stress;GO:0006068 ethanol catabolic process;GO:0006081 aldehyde metabolic process;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0BN86-1", "uniprot_id": "TMM11_RAT", "mass": 21342.0, "length": 190, "protein_name": "Transmembrane protein 11, mitochondrial", "gene_name": "Tmem11", "organism": "Rat", "refseq_name": "transmembrane protein 11, mitochondrial isoform 1", "refseq_ac": "NP_001158015", "gene_names_uniprotkb": "Tmem11", "gene_names_refseq": "RGD1309817; Tmem11", "protein_names_uniprotkb": "Transmembrane protein 11, mitochondrial", "protein_names_refseq": "transmembrane protein 11, mitochondrial isoform 1; transmembrane protein 11, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:303196)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in mitochondrial morphogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0007007 inner mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BN86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q641X8-1", "uniprot_id": "EIF3E_RAT", "mass": 52221.0, "length": 445, "protein_name": "Eukaryotic translation initiation factor 3 subunit E", "gene_name": "Eif3el1; Eif3e", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 3 subunit E", "refseq_ac": "NP_001011990", "gene_names_uniprotkb": "Eif3el1; Eif3e; EIF3E; EIF3S6; Eif3el1; Eif3s6; INT6; Int6; LOC100365062", "gene_names_refseq": "Eif3el1; Eif3e; Eif3s6; eIF-3 p48", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit E; Eukaryotic translation initiation factor 3 subunit 6; eIF-3 p48; eIF3e", "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit 6; eukaryotic translation initiation factor 3 subunit E; eukaryotic translation initiation factor 3, subunit E-like 1", "tax_id": 10116, "disease": "intermittent claudication (Disease Ontology:DOID:3669)", "pathway": " (rno:100365062); (rno:299872); (R-RNO-156827); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "21771896;23737983;29895936", "class_list": "", "function": "A single injection of int6 siRNA into ischemic skeletal muscle promoted angiogenesis via up-regulation of HIF-2alpha-related angiogenic factors in the muscles of the affected hindlimb and reduced gait disturbance., [RefSeq, PubMed]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Int6 (eukaryotic translation initiation factor 3 subunit E)silencing alleviated the maternal clinical manifestations of pre-eclampsia and promoted placental angiogenesis in pregnant L-NAME-treated rats. Publication Status: Online-Only, [RefSeq, PubMed]; Role of eIF3e in trafficking of L-type CaV1.2 channels upon beta-cell stimulation Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0016605 PML body", "go_biological_process": "GO:0090316 positive regulation of intracellular protein transport;GO:0006874 intracellular calcium ion homeostasis;GO:0006413 translational initiation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q641X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERB4-1", "uniprot_id": "CSPG2_RAT", "mass": 300008.0, "length": 2738, "protein_name": "Versican core protein", "gene_name": "Vcan", "organism": "Rat", "refseq_name": "versican core protein isoform 1 precursor", "refseq_ac": "NP_001164029", "gene_names_uniprotkb": "Vcan; Cspg2", "gene_names_refseq": "Cspg2; Vcan", "protein_names_uniprotkb": "Versican core protein; Chondroitin sulfate proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; GHAP; Glial hyaluronate-binding protein; Large fibroblast proteoglycan; PG-M", "protein_names_refseq": "GHAP; PG-M; chondroitin sulfate proteoglycan 2 (versican); chondroitin sulfate proteoglycan core protein 2; glial hyaluronate-binding protein; large fibroblast proteoglycan; versican core protein isoform 1 precursor; versican core protein", "tax_id": 10116, "disease": "intracranial aneurysm (Disease Ontology:DOID:10941); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:114122); (R-RNO-1971475); (R-RNO-2022870); (R-RNO-2022923); (R-RNO-2024101); (R-RNO-3000178); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "10397680;11807809;26395512;31429356;32001344;38843836;9434070;9642104", "class_list": "", "function": "MRNAs of the versican gene with exon 8beta are predicted to be constitutively degraded by nonsense-mediated RNA decay., [RefSeq, PubMed]; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Overexpression of alternatively spliced V3 variant of versican alters arterial smooth muscle cell adhesion, migration, proliferation and cell shape, [RefSeq, PubMed]; The synthesis and secretion of versican isoform V3 by mammalian cells: A role for N-linked glycosylation., [RefSeq, PubMed]; Versican localizes to the nucleus in proliferating mesenchymal cells and suggest role in mitotic spindle organization during cell division., [RefSeq, PubMed]", "predicted_glycosites": 29, "predicted_n_glycosites": 17, "predicted_o_glycosites": 12, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 29, "binding_glycan_count": 0, "secondary_ac_list": "O08592;O88564;Q9R1K4", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0019903 protein phosphatase binding;GO:0030169 low-density lipoprotein particle binding;GO:0008160 protein tyrosine phosphatase activator activity", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007507 heart development;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0001657 ureteric bud development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9ERB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63688-1", "uniprot_id": "CP7B1_RAT", "mass": 48227.0, "length": 414, "protein_name": "25-hydroxycholesterol 7-alpha-hydroxylase", "gene_name": "Cyp7b1", "organism": "Rat", "refseq_name": "25-hydroxycholesterol 7-alpha-hydroxylase", "refseq_ac": "NP_062011", "gene_names_uniprotkb": "Cyp7b1", "gene_names_refseq": "Cyp7b1", "protein_names_uniprotkb": "25-hydroxycholesterol 7-alpha-hydroxylase; 1.14.14.29; Cytochrome P450 7B1; HCT-1; Hippocampal transcript 1 protein; Oxysterol 7-alpha-hydroxylase", "protein_names_refseq": "25-hydroxycholesterol 7-alpha-hydroxylase; HCT-1; cytochrome P450 7B1; cytochrome P450, family 7, subfamily b, polypeptide 1; cytochrome P450, subfamily 7B, polypeptide 1; hippocampal transcript 1 protein; oxysterol 7-alpha-hydroxylase", "tax_id": 10116, "disease": "hereditary spastic paraplegia 5A (Disease Ontology:DOID:0110810); congenital bile acid synthesis defect 3 (Disease Ontology:DOID:0111070)", "pathway": " (rno:25429); (R-RNO-192105); (R-RNO-193368); (R-RNO-193807); (R-RNO-211976)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12029625;12759897;18395092;21029595;22384504;25263657;8530364", "class_list": "", "function": "Abnormal expression of PPARalpha, CYP7B1 and ER may play a role in the pathogenesis of estrogen-induced intrahepatic cholestasis., [RefSeq, PubMed]; CYP7B1 specific activity is highly regulated but does not seem to be rate limiting for bile acid synthesis., [RefSeq, PubMed]; Estrogen suppresses CYP7B1-catalyzed 7alpha-hydroxylation of DEHA, [RefSeq, PubMed]; Hepatic secretion of cholesterol and ABCG5/G8 expression are strongly stimulated in hypophysectomized rats during treatment with thyroid hormone., [RefSeq, PubMed]; Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25-hydroxycholesterol. Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells., [UniProtKB, UniProtKB]; This study deminitrated that CYP7B1 mutations in patients with hereditary spastic paraplegia in French-Canadian., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.23;1.14.14.26;1.14.14.29", "go_molecular_function": "GO:0008396 oxysterol 7-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0008395 steroid hydroxylase activity;GO:0033783 25-hydroxycholesterol 7-alpha-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0007613 memory;GO:0008203 cholesterol metabolic process;GO:0042632 cholesterol homeostasis;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63688-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810Y4-1", "uniprot_id": "CONA1_RAT", "mass": 51397.0, "length": 532, "protein_name": "Collagen alpha-1(XXIII) chain", "gene_name": "Col23a1", "organism": "Rat", "refseq_name": "collagen alpha-1(XXIII) chain", "refseq_ac": "NP_853667", "gene_names_uniprotkb": "Col23a1; LOC100910384; LOC103693323", "gene_names_refseq": "Col23a1", "protein_names_uniprotkb": "Collagen alpha-1(XXIII) chain", "protein_names_refseq": "alpha 1 type XXIII collagen; collagen XXIII; collagen alpha-1(XXIII) chain-like; collagen alpha-1(XXIII) chain; collagen, type XXIII, alpha 1; procollagen, type XXIII, alpha 1", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:353303); (R-RNO-1650814); (R-RNO-8948216)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "12644459", "class_list": "", "function": "Identified in rat prostate carcinoma cells; shows structural homology with the transmembrane collagens XIII and XXV, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q810Y4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q641X7-1", "uniprot_id": "FBX25_RAT", "mass": 41984.0, "length": 357, "protein_name": "F-box only protein 25", "gene_name": "Fbxo25", "organism": "Rat", "refseq_name": "F-box only protein 25", "refseq_ac": "NP_001014261", "gene_names_uniprotkb": "Fbxo25", "gene_names_refseq": "Fbxo25", "protein_names_uniprotkb": "F-box only protein 25", "protein_names_refseq": "F-box only protein 25", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:364637)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16714087", "class_list": "", "function": "FBXO25 is a novel F-box protein analogous to atrogin-1, which is not involved in muscle atrophy.[fbxo25], [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q641X7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1A5S1-1", "uniprot_id": "PRP6_RAT", "mass": 106764.0, "length": 941, "protein_name": "Pre-mRNA-processing factor 6", "gene_name": "Linc00176; Prpf6", "organism": "Rat", "refseq_name": "pre-mRNA-processing factor 6", "refseq_ac": "NP_001073234", "gene_names_uniprotkb": "Linc00176; Prpf6; Linc00176; Prpf6; RGD1561282", "gene_names_refseq": "Prpf6; RGD1307103", "protein_names_uniprotkb": "Pre-mRNA-processing factor 6; PRP6 homolog; U5 snRNP-associated 102 kDa protein; U5-102 kDa protein", "protein_names_refseq": "PRP6 homolog; PRP6 pre-mRNA processing factor 6 homolog; PRP6 pre-mRNA splicing factor 6 homolog; U5 snRNP-associated 102 kDa protein; U5-102 kDa protein; pre-mRNA-processing factor 6", "tax_id": 10116, "disease": "retinitis pigmentosa 60 (Disease Ontology:DOID:0110411)", "pathway": " (rno:366276); (rno:499958); (R-RNO-72165)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0006403 RNA localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1A5S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5DFN3-1", "uniprot_id": "UQCC2_RAT", "mass": 16330.0, "length": 136, "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 2", "gene_name": "Uqcc2", "organism": "Rat", "refseq_name": "ubiquinol-cytochrome-c reductase complex assembly factor 2", "refseq_ac": "NP_001101998", "gene_names_uniprotkb": "Uqcc2; Mnf1; Uqcc1-ps1", "gene_names_refseq": "M19; Mnf1; RGD1306917; Uqcc2", "protein_names_uniprotkb": "Ubiquinol-cytochrome-c reductase complex assembly factor 2; Mitochondrial nucleoid factor 1; Mitochondrial protein M19", "protein_names_refseq": "mitochondrial nucleoid factor 1; mitochondrial protein M19; ubiquinol-cytochrome-c reductase complex assembly factor 2", "tax_id": 10116, "disease": "mitochondrial complex III deficiency nuclear type 7 (Disease Ontology:DOID:0080116)", "pathway": " (rno:361805)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0050796 regulation of insulin secretion;GO:0002082 regulation of oxidative phosphorylation;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0070131 positive regulation of mitochondrial translation;GO:2001014 regulation of skeletal muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DFN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62814-1", "uniprot_id": "E2F5_RAT", "mass": 33224.0, "length": 300, "protein_name": "Transcription factor E2F5", "gene_name": "E2f5", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "E2f5", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor E2F5; E2F-5", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:116651); (R-RNO-1538133); (R-RNO-2173796); (R-RNO-69231)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8589754", "class_list": "", "function": "Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0016528 sarcoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0009887 animal organ morphogenesis;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62814-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63186-1", "uniprot_id": "EI2BD_RAT", "mass": 57809.0, "length": 524, "protein_name": "Translation initiation factor eIF2B subunit delta", "gene_name": "Eif2b4", "organism": "Rat", "refseq_name": "translation initiation factor eIF2B subunit delta", "refseq_ac": "NP_446402", "gene_names_uniprotkb": "Eif2b4; Eif2bd", "gene_names_refseq": "Eif2b4; Eif2b", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit delta; eIF2B GDP-GTP exchange factor subunit delta", "protein_names_refseq": "eIF-2B GDP-GTP exchange factor subunit delta; eIF2B GDP-GTP exchange factor subunit delta; eukaryotic translation initiation factor 2B subunit 4; eukaryotic translation initiation factor 2B, subunit 4 delta; translation initiation factor eIF-2B subunit delta; translation initiation factor eIF2B subunit delta", "tax_id": 10116, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 4 (Disease Ontology:DOID:0070371)", "pathway": " (rno:117019); (R-RNO-72731)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29393594;8929216", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0021766 hippocampus development;GO:0042552 myelination;GO:0050852 T cell receptor signaling pathway;GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63186-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H50-1", "uniprot_id": "FACR1_RAT", "mass": 59268.0, "length": 515, "protein_name": "Fatty acyl-CoA reductase 1", "gene_name": "Far1", "organism": "Rat", "refseq_name": "fatty acyl-CoA reductase 1 isoform 2", "refseq_ac": "NP_001011933", "gene_names_uniprotkb": "Far1", "gene_names_refseq": "Far1; Mlstd2", "protein_names_uniprotkb": "Fatty acyl-CoA reductase 1; 1.2.1.84; Far1", "protein_names_refseq": "fatty acyl-CoA reductase 1 isoform 2; male sterility domain containing 2; male sterility domain-containing protein 2", "tax_id": 10116, "disease": "rhizomelic chondrodysplasia punctate type 4 (Disease Ontology:DOID:0081243)", "pathway": " (rno:293173); (R-RNO-9640463)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "33666503;38843836", "class_list": "", "function": "Catalyzes the reduction of fatty acyl-CoA to fatty alcohols., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (By similarity). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (By similarity). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.2.1.84", "go_molecular_function": "GO:0080019 alcohol-forming very long-chain fatty acyl-CoA reductase activity;GO:0102965 alcohol-forming long-chain fatty acyl-CoA reductase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0008611 ether lipid biosynthetic process;GO:0046474 glycerophospholipid biosynthetic process;GO:0035336 long-chain fatty-acyl-CoA metabolic process;GO:0010025 wax biosynthetic process;GO:0008610 lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66H50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6MG59-1", "uniprot_id": "G6B_RAT", "mass": 25083.0, "length": 232, "protein_name": "Megakaryocyte and platelet inhibitory receptor G6b", "gene_name": "Mpig6b", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mpig6b; G6b", "gene_names_refseq": "", "protein_names_uniprotkb": "Megakaryocyte and platelet inhibitory receptor G6b; Protein G6b", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:406865); (R-RNO-114604)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15060004;29393594", "class_list": "", "function": "Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0007229 integrin-mediated signaling pathway;GO:0007596 blood coagulation;GO:0030218 erythrocyte differentiation;GO:0035855 megakaryocyte development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6MG59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY14-1", "uniprot_id": "F161A_RAT", "mass": 54836.0, "length": 474, "protein_name": "Protein FAM161A", "gene_name": "Fam161a", "organism": "Rat", "refseq_name": "protein FAM161A", "refseq_ac": "NP_001013898", "gene_names_uniprotkb": "Fam161a", "gene_names_refseq": "Fam161a; RGD1304999", "protein_names_uniprotkb": "Protein FAM161A", "protein_names_refseq": "FAM161A, centrosomal protein; family with sequence similarity 161, member A; protein FAM161A", "tax_id": 10116, "disease": "retinitis pigmentosa 28 (Disease Ontology:DOID:0110365)", "pathway": " (rno:289833)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22940612", "class_list": "", "function": "FAM161A-associated RP can be considered as a novel retinal ciliopathy and that its molecular pathogenesis may be related to other ciliopathies., [RefSeq, PubMed]; Involved in ciliogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0000235 astral microtubule;GO:0005813 centrosome;GO:0001917 photoreceptor inner segment;GO:0005814 centriole", "go_biological_process": "GO:0060271 cilium assembly;GO:0044782 cilium organization;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AY14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLJ3-1", "uniprot_id": "AL9A1_RAT", "mass": 53653.0, "length": 494, "protein_name": "4-trimethylaminobutyraldehyde dehydrogenase", "gene_name": "Aldh9a1", "organism": "Rat", "refseq_name": "4-trimethylaminobutyraldehyde dehydrogenase", "refseq_ac": "NP_071609", "gene_names_uniprotkb": "Aldh9a1", "gene_names_refseq": "Aldh9a1; Tmaba-dh", "protein_names_uniprotkb": "4-trimethylaminobutyraldehyde dehydrogenase; 1.2.1.19; 1.2.1.3; 1.2.1.46; 1.2.1.47; Aldehyde dehydrogenase family 9 member A1; Formaldehyde dehydrogenase; Gamma-aminobutyraldehyde dehydrogenase; TMABA-DH; TMABADH", "protein_names_refseq": "4-trimethylaminobutyraldehyde dehydrogenase-like; 4-trimethylaminobutyraldehyde dehydrogenase; TMABADH; aldehyde dehydrogenase 9A1; aldehyde dehydrogenase family 9 member A1; aldehyde dehydrogenase family 9, subfamily A1; formaldehyde dehydrogenase; gamma-aminobutyraldehyde dehydrogenase; gamma-trimethylaminobutyraldehyde dehydrogenase", "tax_id": 10116, "disease": "", "pathway": " (rno:64040); (R-RNO-71262)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10702312;1799975;19150623;26010099", "class_list": "", "function": "Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Foetuses express TMABA-DH mRNA and this expression increased during postnatal life, [RefSeq, PubMed]; TMABA-DH colocalized with myosin light chains in cardiac myocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6GMM4", "ec_number_list": "1.2.1.5;1.2.1.3;1.2.1.94;1.2.1.36;1.2.1.19;1.2.1.28;1.2.1.7;1.2.1.48;1.2.1.31;1.2.1.8;1.7.1.-;1.2.1.47;1.2.1.46", "go_molecular_function": "GO:0018467 formaldehyde dehydrogenase (NAD+) activity;GO:0042802 identical protein binding;GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0051287 NAD binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001889 liver development;GO:0051289 protein homotetramerization;GO:0001822 kidney development;GO:0006081 aldehyde metabolic process;GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JLJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNJ4-1", "uniprot_id": "AMGO2_RAT", "mass": 57759.0, "length": 520, "protein_name": "Amphoterin-induced protein 2", "gene_name": "Amigo2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Amigo2; Ali1", "gene_names_refseq": "", "protein_names_uniprotkb": "Amphoterin-induced protein 2; AMIGO-2; Alivin-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (rno:300186); (R-RNO-9013149); (R-RNO-9013423)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12629050;12843293", "class_list": "", "function": "Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZD6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0043524 negative regulation of neuron apoptotic process;GO:0007420 brain development;GO:0051965 positive regulation of synapse assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TNJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQ20-1", "uniprot_id": "DNJC2_RAT", "mass": 71769.0, "length": 621, "protein_name": "DnaJ homolog subfamily C member 2", "gene_name": "Dnajc2", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 2", "refseq_ac": "NP_446228", "gene_names_uniprotkb": "Dnajc2; Mida1; Zrf1", "gene_names_refseq": "Dnajc2; MIDA1; Zrf2", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 2; Gliosarcoma-related antigen MIDA1; Zuotin-related factor 1", "protein_names_refseq": "(rat homolog) mouse id-associated protein 1; DnaJ (Hsp40) homolog, subfamily C, member 2; dnaJ homolog subfamily C member 2; gliosarcoma-related antigen MIDA1; zuotin related factor 2; zuotin-related factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:116456); (R-RNO-3371453)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11289140;22673903", "class_list": "", "function": "Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5HZY5;Q7TQ18;Q9WVG4", "ec_number_list": "", "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity;GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0043022 ribosome binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0006351 DNA-templated transcription;GO:0006260 DNA replication;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TQ20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHI9-1", "uniprot_id": "CHSTF_RAT", "mass": 65044.0, "length": 561, "protein_name": "Carbohydrate sulfotransferase 15", "gene_name": "Chst15", "organism": "Rat", "refseq_name": "carbohydrate sulfotransferase 15", "refseq_ac": "NP_775432", "gene_names_uniprotkb": "Chst15; Galnac4s6st", "gene_names_refseq": "Chst15; GalNAc4S6ST; Galnac4s-6st", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 15; 2.8.2.33; GalNAc4S-6ST; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase", "protein_names_refseq": "B cell RAG associated protein; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase; carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15; carbohydrate sulfotransferase 15", "tax_id": 10116, "disease": "", "pathway": " (rno:286974); (R-RNO-2022870); (R-RNO-2022923)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21456043", "class_list": "", "function": "Downregulation of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (CS-E) via siRNA targeting of GalNAc4S6ST mitigates chondroitin sulfate proteoglycan-mediated inhibition of neurons, potentially offering an intervention strategy for brain injury., [RefSeq, PubMed]; Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5U363", "ec_number_list": "2.8.2.-;2.8.2.33", "go_molecular_function": "GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0019319 hexose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CHI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGR3-1", "uniprot_id": "CS2LB_RAT", "mass": 19846.0, "length": 169, "protein_name": "Alpha-S2-casein-like B", "gene_name": "Csn1s2b", "organism": "Rat", "refseq_name": "alpha-S2-casein-like B precursor", "refseq_ac": "NP_775129", "gene_names_uniprotkb": "Csn1s2b; Csnd", "gene_names_refseq": "Csn1s2b; Csnd", "protein_names_uniprotkb": "Alpha-S2-casein-like B; Casein alpha S2-like B; Delta-casein", "protein_names_refseq": "alpha-S2-casein-like B precursor; alpha-S2-casein-like B; casein delta; delta-casein", "tax_id": 10116, "disease": "", "pathway": " (rno:286759)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "13679022", "class_list": "", "function": "Important role in the capacity of milk to transport calcium phosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0035375 zymogen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CGR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810F4-1", "uniprot_id": "FAM3C_RAT", "mass": 24714.0, "length": 227, "protein_name": "Protein FAM3C", "gene_name": "Fam3c", "organism": "Rat", "refseq_name": "protein FAM3C precursor", "refseq_ac": "NP_942066", "gene_names_uniprotkb": "Fam3c; Ilei", "gene_names_refseq": "Fam3c", "protein_names_uniprotkb": "Protein FAM3C; Interleukin-like EMT inducer", "protein_names_refseq": "FAM3C-like protein; family with sequence similarity 3, member C; interleukin-like EMT inducer; protein FAM3C precursor; protein FAM3C", "tax_id": 10116, "disease": "", "pathway": " (rno:312159); (R-RNO-114608)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0031410 cytoplasmic vesicle;GO:0005576 extracellular region", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0030223 neutrophil differentiation;GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0050790 regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q810F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U4F3-1", "uniprot_id": "F107B_RAT", "mass": 15586.0, "length": 131, "protein_name": "Protein FAM107B", "gene_name": "Fam107b", "organism": "Rat", "refseq_name": "protein FAM107B isoform 1", "refseq_ac": "NP_001020205", "gene_names_uniprotkb": "Fam107b", "gene_names_refseq": "Fam107b", "protein_names_uniprotkb": "Protein FAM107B", "protein_names_refseq": "protein FAM107B isoform 1; protein FAM107B", "tax_id": 10116, "disease": "", "pathway": " (rno:498796)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U4F3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63484-1", "uniprot_id": "AKT3_RAT", "mass": 55796.0, "length": 479, "protein_name": "RAC-gamma serine/threonine-protein kinase", "gene_name": "Akt3", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Akt3", "gene_names_refseq": "", "protein_names_uniprotkb": "RAC-gamma serine/threonine-protein kinase; 2.7.11.1; PKB gamma; Protein kinase Akt-3; Protein kinase B gamma; RAC-PK-gamma", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); prostate adenocarcinoma (Disease Ontology:DOID:2526); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29414); (R-RNO-1257604); (R-RNO-1358803); (R-RNO-165159); (R-RNO-165181); (R-RNO-198323); (R-RNO-198693); (R-RNO-199418); (R-RNO-211163); (R-RNO-389357); (R-RNO-389513); (R-RNO-392451); (R-RNO-5218920); (R-RNO-5628897); (R-RNO-6804757); (R-RNO-6804758); (R-RNO-6804759); (R-RNO-69202); (R-RNO-69656); (R-RNO-8876198); (R-RNO-8948751); (R-RNO-9607240); (R-RNO-9614399); (R-RNO-9634638); (R-RNO-9755511); (R-RNO-9856649)", "pathway_count": 26, "publication_count": 2, "publication_id_list": "17308302;7488143", "class_list": "", "function": "AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.11.24;2.3.2.27;2.7.11.25;2.7.11.22;2.7.11.23;2.7.4.6;2.7.1.154;2.7.11.38;2.7.11.17;2.7.11.21;2.7.12.2;2.7.1.40;2.7.11.12;2.7.11.26;2.7.11.34;2.7.10.2;3.4.19.12;2.7.1.150;2.7.11.13;4.1.1.32;2.7.11.10;2.7.11.19;2.7.2.3;2.7.11.11;2.7.11.31;3.1.3.16;2.7.11.4;2.3.1.48;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;3.1.2.2;3.6.5.-;2.7.11.39;2.4.99.18;3.4.22.62", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005080 protein kinase C binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0032869 cellular response to insulin stimulus;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63484-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHL0-1", "uniprot_id": "FZD5_RAT", "mass": 64112.0, "length": 585, "protein_name": "Frizzled-5", "gene_name": "Fzd5", "organism": "Rat", "refseq_name": "frizzled-5 precursor", "refseq_ac": "NP_776210", "gene_names_uniprotkb": "Fzd5", "gene_names_refseq": "Fzd5", "protein_names_uniprotkb": "Frizzled-5; Fz-5", "protein_names_refseq": "frizzled family receptor 5; frizzled-5 precursor; frizzled-5; fz-5", "tax_id": 10116, "disease": "coloboma (Disease Ontology:DOID:12270)", "pathway": " (rno:317674); (R-RNO-4086398); (R-RNO-4608870); (R-RNO-4641262); (R-RNO-4641263); (R-RNO-5140745)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "20530549;24205342;29477872", "class_list": "", "function": "Fzd5 has a role in the establishment of neuronal polarity, and in the morphogenesis of neuronal processes Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA-216b was overexposed in diabetic myocardial microvascular endothelial cells and its downregulation may actively enhance angiogenesis in diabetic angiopathy through inverse regulation on FZD5., [RefSeq, PubMed]; Receptor for Wnt proteins (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:20530549). In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (By similarity). In neurons, activation by WNT7A promotes formation of synapses (PubMed:20530549). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). Plays a role in ocular development (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling. In neurons, activation by WNT7A promotes formation of synapses. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in yolk sac angiogenesis and in placental vascularization. Plays a role in ocular development., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0019901 protein kinase binding;GO:0001540 amyloid-beta binding;GO:0031625 ubiquitin protein ligase binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0060718 chorionic trophoblast cell differentiation;GO:0099054 presynapse assembly;GO:0001525 angiogenesis;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CHL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PNM1-1", "uniprot_id": "BTLA_RAT", "mass": 34476.0, "length": 308, "protein_name": "B- and T-lymphocyte attenuator", "gene_name": "Btla", "organism": "Rat", "refseq_name": "B- and T-lymphocyte attenuator precursor", "refseq_ac": "NP_998795", "gene_names_uniprotkb": "Btla", "gene_names_refseq": "Btla", "protein_names_uniprotkb": "B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein", "protein_names_refseq": "B- and T-lymphocyte attenuator precursor; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein", "tax_id": 10116, "disease": "", "pathway": " (rno:407756); (R-RNO-9927353)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;33732243", "class_list": "", "function": "Combined Immunotherapy With Belatacept and BTLA Overexpression Attenuates Acute Rejection Following Kidney Transplantation. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q569B2", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0098797 plasma membrane protein complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0042130 negative regulation of T cell proliferation;GO:0002250 adaptive immune response;GO:0070372 regulation of ERK1 and ERK2 cascade;GO:0030889 negative regulation of B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PNM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VII6-1", "uniprot_id": "CTL1_RAT", "mass": 73092.0, "length": 656, "protein_name": "Choline transporter-like protein 1", "gene_name": "Slc44a1", "organism": "Rat", "refseq_name": "choline transporter-like protein 1 isoform 1", "refseq_ac": "NP_001029024", "gene_names_uniprotkb": "Slc44a1; Cd92; Cdw92; Ctl1", "gene_names_refseq": "Cdw92; Ctl1; Slc44a1", "protein_names_uniprotkb": "Choline transporter-like protein 1; Solute carrier family 44 member 1", "protein_names_refseq": "CDW92 antigen; choline transporter-like protein 1 isoform 1; choline transporter-like protein 1; solute carrier family 44 (choline transporter), member 1", "tax_id": 10116, "disease": "high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (rno:85254); (R-RNO-1483191); (R-RNO-6798163); (R-RNO-9958517)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10677542;12007839;15691711;15715662;16000150;19236841;24090084;28119456;30776907", "class_list": "", "function": "CTL1-deficient Schwann cells are significantly impaired in their ability to myelinate neurites in vitro., [RefSeq, PubMed]; Choline transporter, acts as a choline/H+ antiporter (PubMed:19236841). Also acts as a high-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (PubMed:19236841). Involved in membrane synthesis and myelin production (By similarity)., [UniProtKB, UniProtKB, PubMed]; Choline transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SLC44A1 acts as a choline transporter both in the plasma membrane and in the mitochondria. Novel aspects of choline transport regulation in the muscle, nervous system, and cancer are reviewed. Review. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJZ7", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015871 choline transport;GO:0034229 ethanolamine transport;GO:0015695 organic cation transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8VII6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6MG55-1", "uniprot_id": "ABHGA_RAT", "mass": 63038.0, "length": 558, "protein_name": "Phosphatidylserine lipase ABHD16A", "gene_name": "Abhd16a", "organism": "Rat", "refseq_name": "phosphatidylserine lipase ABHD16A", "refseq_ac": "NP_997696", "gene_names_uniprotkb": "Abhd16a; Bat5", "gene_names_refseq": "Abhd16a; Bat5; NG26", "protein_names_uniprotkb": "Phosphatidylserine lipase ABHD16A; 3.1.-.-; 3.1.1.23; Abhydrolase domain-containing protein 16A; Alpha/beta hydrolase domain-containing protein 16A; HLA-B-associated transcript 5 homolog; Monoacylglycerol lipase ABHD16A", "protein_names_refseq": "HLA-B associated transcript 5; HLA-B-associated transcript 5 homolog; abhydrolase domain-containing protein 16A; alpha/beta hydrolase domain-containing protein 16A; monoacylglycerol lipase ABHD16A; phosphatidylserine lipase ABHD16A; protein ABHD16A; protein BAT5", "tax_id": 10116, "disease": "hereditary spastic paraplegia 86 (Disease Ontology:DOID:0112342)", "pathway": " (rno:361796)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15060004;25290914;38843836", "class_list": "", "function": "BAT5 is a genuine lipase with preference for long-chain unsaturated monoacylglycerols, and could in this capacity regulate glycerolipid metabolism in vivo as well. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.4;3.1.1.23;3.1.1.79;3.1.1.6;3.1.1.3;3.1.1.5;3.3.2.9;3.1.1.26;3.5.1.99;3.1.1.-;3.1.1.111;3.1.1.32;2.3.1.-;3.1.-.-", "go_molecular_function": "GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0052651 monoacylglycerol catabolic process;GO:1905344 prostaglandin catabolic process;GO:0006660 phosphatidylserine catabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6MG55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3M6-1", "uniprot_id": "ERC2_RAT", "mass": 110618.0, "length": 957, "protein_name": "ERC protein 2", "gene_name": "Erc2", "organism": "Rat", "refseq_name": "ERC protein 2 isoform 2", "refseq_ac": "NP_740768", "gene_names_uniprotkb": "Erc2; Cast1; Cmbp", "gene_names_refseq": "CAST; Cmbp; Erc2", "protein_names_uniprotkb": "ERC protein 2; CAST1; CAZ-associated structural protein 1; Cast; Cytomatrix protein p110", "protein_names_refseq": "CAST1; CAZ-associated structural protein 1; ERC protein 2 isoform 2; ERC protein 2; cytomatrix protein p110", "tax_id": 10116, "disease": "", "pathway": " (rno:259269)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12163476;12391317;12923177;14723704;14734538;22673903;36555116;38843836", "class_list": "", "function": "Characterized a family of active zone proteins whose binding to RIMs, presynaptic active zone proteins that regulate neurotransmitter release, is regulated by tissue-specific alternative splicing, [RefSeq, PubMed]; Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the miR-125a-5p/MAT2A Axis. Publication Status: Online-Only, [RefSeq, PubMed]; RIM1- or Bassoon-binding region of CAST impairs synaptic transmission in cultured superior cervical ganglion neurons, [RefSeq, PubMed]; The interaction between ERC2 and liprin-alpha may be involved in the presynaptic localization of liprin-alpha and the molecular organization of presynaptic active zones., [RefSeq, PubMed]; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIZ0", "ec_number_list": "", "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005783 endoplasmic reticulum;GO:0005798 Golgi-associated vesicle", "go_biological_process": "GO:0048790 maintenance of presynaptic active zone structure;GO:0050808 synapse organization;GO:0007416 synapse assembly;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration;GO:0016082 synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K3M6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PF5-1", "uniprot_id": "FUBP2_RAT", "mass": 74226.0, "length": 721, "protein_name": "Far upstream element-binding protein 2", "gene_name": "Khsrp", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Khsrp; Fubp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Far upstream element-binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; MAP2 RNA trans-acting protein 1; MARTA1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171137); (R-RNO-450604)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12358751;17177604;22673903", "class_list": "", "function": "Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs (By similarity). Binds to the dendritic targeting element and may play a role in mRNA trafficking., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0044183 protein folding chaperone;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006355 regulation of DNA-templated transcription;GO:0043488 regulation of mRNA stability;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99PF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIL3-1", "uniprot_id": "ILF3_RAT", "mass": 95935.0, "length": 897, "protein_name": "Interleukin enhancer-binding factor 3", "gene_name": "Ilf3", "organism": "Rat", "refseq_name": "interleukin enhancer-binding factor 3 isoform 1", "refseq_ac": "NP_445864", "gene_names_uniprotkb": "Ilf3", "gene_names_refseq": "Ilf3", "protein_names_uniprotkb": "Interleukin enhancer-binding factor 3", "protein_names_refseq": "M phase phosphoprotein 4; interleukin enhancer-binding factor 3 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:84472); (R-RNO-9833482)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10749851;22673903;31536826;32196615;36222883", "class_list": "", "function": "ILF3 protein inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide. Its expression is regulated by angiotensin II., [RefSeq, PubMed]; Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway., [RefSeq, PubMed]; RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs., [UniProtKB, UniProtKB]; The interleukin-enhanced binding factor 3-mediated inhibition of nitric oxide production via phosphoinositide 3-kinase/protein kinase B pathway contributes to central cardiovascular regulation in the rostral ventrolateral medulla in hypertension., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0001618 virus receptor activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JIL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJ22-1", "uniprot_id": "ERAP1_RAT", "mass": 106419.0, "length": 930, "protein_name": "Endoplasmic reticulum aminopeptidase 1", "gene_name": "Erap1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Erap1; Appils; Arts1", "gene_names_refseq": "", "protein_names_uniprotkb": "Endoplasmic reticulum aminopeptidase 1; 3.4.11.-; A-LAP; ARTS-1; Adipocyte-derived leucine aminopeptidase; Aminopeptidase PILS; PILS-AP; Puromycin-insensitive leucyl-specific aminopeptidase", "protein_names_refseq": "", "tax_id": 10116, "disease": "severe pre-eclampsia (Disease Ontology:DOID:13129); endometrial carcinoma (Disease Ontology:DOID:2871); cervix carcinoma (Disease Ontology:DOID:2893)", "pathway": " (R-RNO-983170)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10824104;29393594", "class_list": "", "function": "Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJ23", "ec_number_list": "3.4.11.-", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis;GO:0043171 peptide catabolic process;GO:0045766 positive regulation of angiogenesis;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJ22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60587-1", "uniprot_id": "ECHB_RAT", "mass": 51414.0, "length": 475, "protein_name": "Trifunctional enzyme subunit beta, mitochondrial", "gene_name": "Hadhb", "organism": "Rat", "refseq_name": "trifunctional enzyme subunit beta, mitochondrial precursor", "refseq_ac": "NP_598302", "gene_names_uniprotkb": "Hadhb", "gene_names_refseq": "Hadhb; TP-beta", "protein_names_uniprotkb": "Trifunctional enzyme subunit beta, mitochondrial; 3-oxoacyl-CoA thiolase; Acetyl-CoA acyltransferase; Beta-ketothiolase; LCKAT; Long chain 3-ketoacyl-CoA thiolase; TP-beta", "protein_names_refseq": "hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit; mitochondrial trifunctional protein, beta subunit; trifunctional enzyme subunit beta, mitochondrial precursor; trifunctional enzyme subunit beta, mitochondrial", "tax_id": 10116, "disease": "mitochondrial trifunctional protein deficiency 2 (Disease Ontology:DOID:0060999); mitochondrial trifunctional protein deficiency (Disease Ontology:DOID:0111277); Alzheimer's disease (Disease Ontology:DOID:10652); lipid metabolism disorder (Disease Ontology:DOID:3146); mitochondrial metabolism disease (Disease Ontology:DOID:700); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:171155); (R-RNO-1482798); (R-RNO-77285); (R-RNO-77305); (R-RNO-77310); (R-RNO-77346); (R-RNO-77348); (R-RNO-77350)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "1730633;18640292;26446791;27213235;34502162;38843836;8253773", "class_list": "", "function": "Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The catalytic residues of the MTP beta-subunit are positioned in the active site similarly to those of monofunctional 3-ketoacyl-CoA thiolase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.16;2.3.1.9;2.3.1.155;2.3.1.176;3.1.2.-;3.1.2.2;3.1.2.1", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0003985 acetyl-CoA C-acetyltransferase activity;GO:0050633 acetyl-CoA C-myristoyltransferase activity;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0071222 cellular response to lipopolysaccharide;GO:0010467 gene expression;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q60587-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q67EQ0-1", "uniprot_id": "CLC4A_RAT", "mass": 27404.0, "length": 240, "protein_name": "C-type lectin domain family 4 member A", "gene_name": "Clec4a", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Clec4a; Clecsf6; Dcir", "gene_names_refseq": "", "protein_names_uniprotkb": "C-type lectin domain family 4 member A; C-type lectin superfamily member 6; Dendritic cell inhibitory receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-6798695)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15368084", "class_list": "", "function": "C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0036037 CD8-positive, alpha-beta T cell activation;GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0001878 response to yeast;GO:0045087 innate immune response;GO:0032720 negative regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q67EQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64611-1", "uniprot_id": "CSAD_RAT", "mass": 55249.0, "length": 493, "protein_name": "Cysteine sulfinic acid decarboxylase", "gene_name": "Csad", "organism": "Rat", "refseq_name": "cysteine sulfinic acid decarboxylase", "refseq_ac": "NP_068518", "gene_names_uniprotkb": "Csad; Csd", "gene_names_refseq": "Csad", "protein_names_uniprotkb": "Cysteine sulfinic acid decarboxylase; 4.1.1.11; 4.1.1.29; Aspartate 1-decarboxylase; Cysteine-sulfinate decarboxylase; Sulfinoalanine decarboxylase", "protein_names_refseq": "aspartate 1-decarboxylase; cysteine sulfinic acid decarboxylase; cysteine-sulfinate decarboxylase; sulfinoalanine decarboxylase", "tax_id": 10116, "disease": "", "pathway": " (rno:60356)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10461879;17634260;7772604;8679699", "class_list": "", "function": "Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate., [UniProtKB, UniProtKB]; Mammary and hepatic cysteine dioxygenase and cysteine sulfinic acid decarboxylase in pregnant and nursing rats are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q546T1;Q64577;Q9R1F6", "ec_number_list": "4.1.1.29;4.1.1.11", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004782 sulfinoalanine decarboxylase activity;GO:0004068 aspartate 1-decarboxylase activity;GO:0016831 carboxy-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042412 taurine biosynthetic process;GO:0019449 L-cysteine catabolic process to hypotaurine;GO:0019452 L-cysteine catabolic process to taurine;GO:0042423 catecholamine biosynthetic process;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q64611-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IV68-1", "uniprot_id": "FACD2_RAT", "mass": 163621.0, "length": 1451, "protein_name": "Fanconi anemia group D2 protein homolog", "gene_name": "Fancd2", "organism": "Rat", "refseq_name": "Fanconi anemia group D2 protein homolog", "refseq_ac": "NP_001001719", "gene_names_uniprotkb": "Fancd2", "gene_names_refseq": "Fancd2", "protein_names_uniprotkb": "Fanconi anemia group D2 protein homolog; Protein FACD2", "protein_names_refseq": "Fanconi anemia D2 protein; Fanconi anemia group D2 protein homolog; Fanconi anemia, complementation group D2", "tax_id": 10116, "disease": "Fanconi anemia complementation group D2 (Disease Ontology:DOID:0111083); Fanconi anemia (Disease Ontology:DOID:13636); breast cancer (Disease Ontology:DOID:1612); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (rno:312641); (R-RNO-6783310)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Required for maintenance of chromosomal stability (By similarity). Promotes accurate and efficient pairing of homologs during meiosis (By similarity). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (By similarity). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (By similarity). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin (By similarity). May also be involved in B-cell immunoglobulin isotype switching (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016604 nuclear body;GO:0000793 condensed chromosome", "go_biological_process": "GO:2000348 regulation of CD40 signaling pathway;GO:0010332 response to gamma radiation;GO:0006974 DNA damage response;GO:0034599 cellular response to oxidative stress;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IV68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6RY07-1", "uniprot_id": "CHIA_RAT", "mass": 51951.0, "length": 473, "protein_name": "Acidic mammalian chitinase", "gene_name": "Chia", "organism": "Rat", "refseq_name": "acidic mammalian chitinase precursor", "refseq_ac": "NP_997469", "gene_names_uniprotkb": "Chia", "gene_names_refseq": "Chia", "protein_names_uniprotkb": "Acidic mammalian chitinase; 3.2.1.14; AMCase", "protein_names_refseq": "AMCase; acidic mammalian chitinase precursor; acidic mammalian chitinase; eosinophil chemotactic cytokine; small acid mammalian chitinase", "tax_id": 10116, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); sinusitis (Disease Ontology:DOID:0050127); silicosis (Disease Ontology:DOID:10325); cryptococcosis (Disease Ontology:DOID:12053); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); asthma (Disease Ontology:DOID:2841); neuromyelitis optica (Disease Ontology:DOID:8869)", "pathway": " (rno:113901); (R-RNO-189085)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "24155872", "class_list": "glycogene;glycosylhydrolase", "function": "Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding (By similarity)., [UniProtKB]; Invasive pulmonary aspergillosis in immunocompromised rats caused a dramatic increase in chitinase activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.1.14", "go_molecular_function": "GO:0019900 kinase binding;GO:0004568 chitinase activity;GO:0008843 endochitinase activity;GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0032722 positive regulation of chemokine production;GO:0000272 polysaccharide catabolic process;GO:0002532 production of molecular mediator involved in inflammatory response;GO:0006032 chitin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6RY07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q642C0-1", "uniprot_id": "DNJC8_RAT", "mass": 29813.0, "length": 253, "protein_name": "DnaJ homolog subfamily C member 8", "gene_name": "Dnajc8", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 8", "refseq_ac": "NP_001013186", "gene_names_uniprotkb": "Dnajc8", "gene_names_refseq": "Dnajc8", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 8", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 8; dnaJ homolog subfamily C member 8", "tax_id": 10116, "disease": "", "pathway": " (rno:313035); (R-RNO-9770562)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q642C0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6MG49-1", "uniprot_id": "BAG6_RAT", "mass": 120012.0, "length": 1146, "protein_name": "Large proline-rich protein BAG6", "gene_name": "Bag6", "organism": "Rat", "refseq_name": "large proline-rich protein BAG6 isoform 1", "refseq_ac": "NP_001029140", "gene_names_uniprotkb": "Bag6; Bat3", "gene_names_refseq": "Bag6; Bat3", "protein_names_uniprotkb": "Large proline-rich protein BAG6; BCL2-associated athanogene 6; HLA-B-associated transcript 3", "protein_names_refseq": "BCL2-associated athanogene 6; HLA-B-associated transcript 3; large proline-rich protein BAG6 isoform 1; large proline-rich protein BAG6; large proline-rich protein BAT3", "tax_id": 10116, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); osteoarthritis (Disease Ontology:DOID:8398); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (rno:94342)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10390159;15060004;22673903", "class_list": "", "function": "ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response. BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress. By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis. Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway., [UniProtKB, UniProtKB]; Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May mediate ricin-induced apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q498N5;Q9WTN8", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6MG49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JM53-1", "uniprot_id": "AIFM1_RAT", "mass": 66723.0, "length": 612, "protein_name": "Apoptosis-inducing factor 1, mitochondrial", "gene_name": "Aifm1", "organism": "Rat", "refseq_name": "apoptosis-inducing factor 1, mitochondrial precursor", "refseq_ac": "NP_112646", "gene_names_uniprotkb": "Aifm1; Aif; Pdcd8", "gene_names_refseq": "Aifm1; Aif; Pdcd8", "protein_names_uniprotkb": "Apoptosis-inducing factor 1, mitochondrial; 1.6.99.-; Programmed cell death protein 8", "protein_names_refseq": "apoptosis-inducing factor 1, mitochondrial precursor; apoptosis-inducing factor 1, mitochondrial-like; apoptosis-inducing factor 1, mitochondrial; apoptosis-inducing factor, mitochondrion-associated 1; programmed cell death 8 (apoptosis-inducing factor); programmed cell death protein 8", "tax_id": 10116, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); Charcot-Marie-Tooth disease X-linked recessive 4 (Disease Ontology:DOID:0110212); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); combined oxidative phosphorylation deficiency 6 (Disease Ontology:DOID:0111502); X-linked deafness 5 (Disease Ontology:DOID:0111741); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); retinal detachment (Disease Ontology:DOID:5327)", "pathway": " (rno:83533)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12453066;12871572;22673903;32338336;33171392;33527194;33940381;34502162;38801174", "class_list": "", "function": "AIF translocation from mitochondria to the nucleus could be a key event leading to chromatin condensation and DNA degradation in cerebellar granule cells exposed to MeHg and H2O2., [RefSeq, PubMed]; AIF-mediated cell death may be an important mechanism of hypoxia-ischemia induced neuronal loss in the immature brain, [RefSeq, PubMed]; Apoptosis-inducing factor plays a role in the pathogenesis of hepatic and renal injury during cholestasis., [RefSeq, PubMed]; Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats., [RefSeq, PubMed]; CaMK II -induced Drp1 phosphorylation contributes to blue light-induced AIF-mediated necroptosis in retinal R28 cells., [RefSeq, PubMed]; Expression pattern of apoptosis-inducing factor in the kidneys of streptozotocin-induced diabetic rats., [RefSeq, PubMed]; Functions both as NADH oxidoreductase and as regulator of apoptosis (By similarity). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner (By similarity). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (By similarity). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (By similarity). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import., [UniProtKB, UniProtKB]; Synaptic vesicle protein 2A mitigates parthanatos via apoptosis-inducing factor in a rat model of pharmacoresistant epilepsy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q548E3", "ec_number_list": "1.6.99.1;1.6.99.-", "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0072572 poly-ADP-D-ribose binding;GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0071949 FAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0033108 mitochondrial respiratory chain complex assembly;GO:0002931 response to ischemia;GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JM53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63135-1", "uniprot_id": "CR1L_RAT", "mass": 61680.0, "length": 559, "protein_name": "Complement component receptor 1-like protein", "gene_name": "Cd46; Cr1l", "organism": "Rat", "refseq_name": "complement component receptor 1-like protein isoform 3 precursor", "refseq_ac": "NP_001005265", "gene_names_uniprotkb": "Cd46; Cr1l; Cd46; Cr1l; Crry", "gene_names_refseq": "Cr1l; Cr1; Crry", "protein_names_uniprotkb": "Complement component receptor 1-like protein; Antigen 5I2; Complement regulatory protein Crry", "protein_names_refseq": "5I2 antigen; Complement receptor related protein; antigen 5I2; complement component (3b/4b) receptor 1-like; complement component receptor 1-like protein isoform 3 precursor; complement component receptor 1-like protein; complement receptor type 1; complement regulatory protein Crry-like", "tax_id": 10116, "disease": "meningococcal meningitis (Disease Ontology:DOID:0080176); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); pre-eclampsia (Disease Ontology:DOID:10591); age related macular degeneration (Disease Ontology:DOID:10871); malaria (Disease Ontology:DOID:12365); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); multiple sclerosis (Disease Ontology:DOID:2377); thrombophilia (Disease Ontology:DOID:2452); contact dermatitis (Disease Ontology:DOID:2773); breast carcinoma (Disease Ontology:DOID:3459); renal cell carcinoma (Disease Ontology:DOID:4450); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074); viral infectious disease (Disease Ontology:DOID:934); bacterial meningitis (Disease Ontology:DOID:9470); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:54243); (R-RNO-6798695); (R-RNO-977606)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12767833;15474557;21795784;22673903;34563046;7534798;7590969;8117286;8144902", "class_list": "", "function": "Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance., [UniProtKB, PubMed, PubMed, PubMed]; Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in the fusion of the spermatozoa with the oocyte during fertilization., [UniProtKB, UniProtKB, UniProtKB]; Structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70 degrees bend between domains 3 and 4, [RefSeq, PubMed]; This gene encodes a membrane-bound inhibitor of complement activation, which contains several tandemly arranged short consensus repeats (SCRs) of approximately 60 amino acids. The encoded protein may play a role in tumor immune surveillance, which is unrelated to complement inhibition. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63612", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0045087 innate immune response;GO:0071456 cellular response to hypoxia;GO:0007565 female pregnancy;GO:0045959 negative regulation of complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q63135-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TP65-1", "uniprot_id": "ANKL2_RAT", "mass": 106439.0, "length": 964, "protein_name": "Ankyrin repeat and LEM domain-containing protein 2", "gene_name": "Ankle2", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ankle2; Ab2-034; Lem4", "gene_names_refseq": "", "protein_names_uniprotkb": "Ankyrin repeat and LEM domain-containing protein 2; LEM domain-containing protein 4; Liver regeneration-related protein LRRG057", "protein_names_refseq": "", "tax_id": 10116, "disease": "primary autosomal recessive microcephaly 16 (Disease Ontology:DOID:0070289); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (R-RNO-2995383); (R-RNO-9013404); (R-RNO-9013408)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LMJ0;F1M1M8", "ec_number_list": "", "go_molecular_function": "GO:0004860 protein kinase inhibitor activity;GO:0051721 protein phosphatase 2A binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0007417 central nervous system development;GO:0007084 mitotic nuclear membrane reassembly;GO:0042326 negative regulation of phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TP65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHS1-1", "uniprot_id": "EPAS1_RAT", "mass": 96718.0, "length": 874, "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "Epas1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Epas1; Hif2a", "gene_names_refseq": "", "protein_names_uniprotkb": "Endothelial PAS domain-containing protein 1; EPAS-1; HIF-2-alpha; HIF2-alpha; Hypoxia-inducible factor 2-alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); familial erythrocytosis 4 (Disease Ontology:DOID:0080339); pre-eclampsia (Disease Ontology:DOID:10591); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); von Hippel-Lindau disease (Disease Ontology:DOID:14175); cancer (Disease Ontology:DOID:162); acute kidney failure (Disease Ontology:DOID:3021); intermittent claudication (Disease Ontology:DOID:3669); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); polycythemia (Disease Ontology:DOID:8432); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29452); (R-RNO-1234158); (R-RNO-1234174); (R-RNO-1234176); (R-RNO-8951664)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "11237857", "class_list": "", "function": "Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JHS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GX86-1", "uniprot_id": "HROB_RAT", "mass": 65159.0, "length": 607, "protein_name": "Homologous recombination OB-fold protein", "gene_name": "Hrob", "organism": "Rat", "refseq_name": "homologous recombination OB-fold protein", "refseq_ac": "NP_001017988", "gene_names_uniprotkb": "Hrob; LOC303566", "gene_names_refseq": "Hrob", "protein_names_uniprotkb": "Homologous recombination OB-fold protein", "protein_names_refseq": "E2F1-inducible; homologous recombination OB-fold protein; uncharacterized protein C17orf53 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:303566)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16288221", "class_list": "", "function": "DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GX87", "ec_number_list": "", "go_molecular_function": "GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006974 DNA damage response;GO:0036297 interstrand cross-link repair;GO:0000725 recombinational repair;GO:0000731 DNA synthesis involved in DNA repair;GO:0007292 female gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6GX86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99NB7-1", "uniprot_id": "ACO12_RAT", "mass": 62018.0, "length": 556, "protein_name": "Acetyl-coenzyme A thioesterase", "gene_name": "Acot12", "organism": "Rat", "refseq_name": "acetyl-coenzyme A thioesterase", "refseq_ac": "NP_570103", "gene_names_uniprotkb": "Acot12; Cach1; Cach", "gene_names_refseq": "Acot12; Cach; rACH", "protein_names_uniprotkb": "Acetyl-coenzyme A thioesterase; 3.1.2.1; Acyl-CoA thioester hydrolase 12; Acyl-CoA thioesterase 12; Acyl-coenzyme A thioesterase 12; CACH-1; Cytoplasmic acetyl-CoA hydrolase 1; rACH; rCACH-1", "protein_names_refseq": "CACH-1; acetyl-coenzyme A thioesterase; acyl-CoA thioester hydrolase 12; acyl-coenzyme A thioesterase 12; cytoplasmic acetyl-CoA hydrolase 1; cytosolic acetyl-CoA hydrolase; rCACH-1", "tax_id": 10116, "disease": "liver cancer (Disease Ontology:DOID:3571)", "pathway": " (rno:170570); (R-RNO-77289)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11322891;16476568;23709691;6136404", "class_list": "", "function": "Acetyl-CoA-hydrolyzing activity in isolated mitochondria was induced by the treatment of rats with di(2-ehtylhexyl)phthalate (DEHP)., [RefSeq, PubMed]; Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes acetyl-CoA., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The results suggest that cytosolic acetyl-CoA levels in the liver are controlled by lipid metabolites and hormones, which result in allosteric enzymatic and transcriptional regulation of ACOT12., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.2;3.1.2.-;3.1.2.1;2.3.1.16;2.3.1.9;3.1.2.27;3.1.2.11;3.1.2.3;3.1.2.5", "go_molecular_function": "GO:0003986 acetyl-CoA hydrolase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0052689 carboxylic ester hydrolase activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0006084 acetyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99NB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62758-1", "uniprot_id": "5HT4R_RAT", "mass": 46107.0, "length": 406, "protein_name": "5-hydroxytryptamine receptor 4", "gene_name": "Htr4", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 4", "refseq_ac": "NP_036985", "gene_names_uniprotkb": "Htr4", "gene_names_refseq": "Htr4", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4", "protein_names_refseq": "5 hydroxytryptamine (serotonin) receptor 4; 5-HT-4; 5-HT4 receptor (two splicing variants L and S); 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled; 5-hydroxytryptamine receptor 4; serotonin receptor 4", "tax_id": 10116, "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); glucose metabolism disease (Disease Ontology:DOID:4194); anorexia nervosa (Disease Ontology:DOID:8689)", "pathway": " (rno:25324); (R-RNO-390666)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10220570;11986365;12855812;27894797;28754313;30696976;30929589;33220305;7656980;7796807", "class_list": "", "function": "Findings suggested that unilateral lesions of the Substantia Nigra induced working memory impairment and up-regulation of 5-HT4 receptors in the Lateral Habenula. Activation and blockade of LHb 5-HT4 receptors improved working memory, that were related to the change of monoamines levels., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10220570, PubMed:7796807). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hypertension exhibits 5-HT4 receptor as a modulator of sympathetic neurotransmission in the rat mesenteric vasculature., [RefSeq, PubMed]; Results indicate that visceral nociceptive transmission through the caudal medulla is negatively modulated by descending serotonin type 4 receptor dependent mechanisms., [RefSeq, PubMed]; Results report that serotonin 4(a) receptors are strongly expressed in respiratory Pre-Boetzinger complex neurons and that their selective activation protects spontaneous respiratory activity, [RefSeq, PubMed]; Results suggest that 5-HT(4) receptors can modulate GABAergic signalling bidirectionally, depending on the basal PKA activation levels that are determined by neuronal activity, [RefSeq, PubMed]; Serotonin enhances depolarizing spontaneous fluctuations, excitability, and ongoing activity in isolated rat DRG neurons via 5-HT4 receptors and cAMP-dependent mechanisms., [RefSeq, PubMed]; Study suggests a novel role for the 5-HT4 receptor in facilitation of dendrite formation in which intracellular signaling of PKA and the BDNF-TrkB system may be involved., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O89034;Q62757;Q63006", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0099589 serotonin receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0050890 cognition;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007214 gamma-aminobutyric acid signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62758-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RKI8-1", "uniprot_id": "MITOS_RAT", "mass": 77770.0, "length": 714, "protein_name": "Mitochondrial potassium channel ATP-binding subunit", "gene_name": "Abcb8", "organism": "Rat", "refseq_name": "mitochondrial potassium channel ATP-binding subunit precursor", "refseq_ac": "NP_001007797", "gene_names_uniprotkb": "Abcb8; Mitosur", "gene_names_refseq": "Abcb8; MITOSUR", "protein_names_uniprotkb": "Mitochondrial potassium channel ATP-binding subunit; ABCB8; ATP-binding cassette sub-family B member 8, mitochondrial; MITOSUR; Mitochondrial sulfonylurea-receptor", "protein_names_refseq": "ABC transporter 8; ATP-binding cassette sub-family B member 8, mitochondrial; ATP-binding cassette, sub-family B (MDR/TAP), member 8; ATP-binding cassette, sub-family B, member 8; ATP-binding cassette, subfamily B (MDR/TAP), member 8; mitochondrial potassium channel ATP-binding subunit precursor; mitochondrial potassium channel ATP-binding subunit; mitochondrial sulfonylurea-receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:362302); (R-RNO-1369007)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16390497;22375032", "class_list": "", "function": "ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). v. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix (By similarity). Plays a role in mitochondrial iron transport (By similarity). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; In the testis, rat abcb8 was expressed both in the somatic Sertoli cells and peritubular cells and in the germline (spermatogonia and pachytene spermatocytes)., [RefSeq, PubMed]; These results indicate that ABCB8 is essential for normal cardiac function, maintenance of mitochondrial iron homeostasis and maturation of cytosolic Fe/S proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0QVT4", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0062157 mitochondrial ATP-gated potassium channel complex", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006884 cell volume homeostasis;GO:0071805 potassium ion transmembrane transport;GO:0140141 mitochondrial potassium ion transmembrane transport;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RKI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XI56-1", "uniprot_id": "ERIP6_RAT", "mass": 67964.0, "length": 602, "protein_name": "Glutamate-rich protein 6", "gene_name": "Erich6", "organism": "Rat", "refseq_name": "glutamate-rich protein 6", "refseq_ac": "NP_001019471", "gene_names_uniprotkb": "Erich6; Fam194a", "gene_names_refseq": "Erich6; Fam194a", "protein_names_uniprotkb": "Glutamate-rich protein 6; Protein FAM194A", "protein_names_refseq": "family with sequence similarity 194, member A; glutamate-rich protein 6; protein FAM194A", "tax_id": 10116, "disease": "", "pathway": " (rno:499626)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1D1-1", "uniprot_id": "CTCF_RAT", "mass": 83880.0, "length": 737, "protein_name": "Transcriptional repressor CTCF", "gene_name": "Ctcf", "organism": "Rat", "refseq_name": "transcriptional repressor CTCF", "refseq_ac": "NP_114012", "gene_names_uniprotkb": "Ctcf", "gene_names_refseq": "Ctcf", "protein_names_uniprotkb": "Transcriptional repressor CTCF; 11-zinc finger protein; CCCTC-binding factor; CTCFL paralog", "protein_names_refseq": "11-zinc finger protein; CCCTC-binding factor (zinc finger protein); CTCFL paralog; transcriptional repressor CTCF", "tax_id": 10116, "disease": "female breast cancer (Disease Ontology:DOID:0050671); autosomal dominant intellectual developmental disorder 21 (Disease Ontology:DOID:0070051); childhood acute lymphocytic leukemia (Disease Ontology:DOID:0080144); breast cancer (Disease Ontology:DOID:1612); basal cell carcinoma (Disease Ontology:DOID:2513); skin squamous cell carcinoma (Disease Ontology:DOID:3151); breast carcinoma (Disease Ontology:DOID:3459); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (rno:83726); (R-RNO-9943962)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "32125046;35927544;38774923", "class_list": "", "function": "CCCTC-binding factor suppresses alpha-2-macroglobulin transcription to improve vascular endothelial cell functions in lower extremity arteriosclerosis obliterans., [RefSeq, PubMed]; Chromatin binding factor that binds to DNA sequence specific sites and regulates the 3D structure of chromatin. Binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures, such as the nuclear lamina. Defines the boundaries between active and heterochromatic DNA via binding to chromatin insulators, thereby preventing interaction between promoter and nearby enhancers and silencers. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus (By similarity). On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Regulates asynchronous replication of IGF2/H19. Plays a critical role in gene silencing over considerable distances in the genome (By similarity). Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays an important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning (By similarity). Seems to be essential for homologous X-chromosome pairing (By similarity). May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis. Acts as a transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression (By similarity). Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription (By similarity). Seems to act as tumor suppressor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MiR-383-5p Regulated by the Transcription Factor CTCF Affects Neuronal Impairment in Cerebral Ischemia by Mediating Deacetylase HDAC9 Activity., [RefSeq, PubMed]; Up-regulation of SNHG16 induced by CTCF accelerates cardiac hypertrophy by targeting miR-182-5p/IGF1 axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043035 chromatin insulator sequence binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000775 chromosome, centromeric region;GO:0000793 condensed chromosome", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R1D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H07-1", "uniprot_id": "FANK1_RAT", "mass": 38411.0, "length": 344, "protein_name": "Fibronectin type 3 and ankyrin repeat domains 1 protein", "gene_name": "Fank1", "organism": "Rat", "refseq_name": "fibronectin type 3 and ankyrin repeat domains 1 protein", "refseq_ac": "NP_001008348", "gene_names_uniprotkb": "Fank1", "gene_names_refseq": "Fank1", "protein_names_uniprotkb": "Fibronectin type 3 and ankyrin repeat domains 1 protein", "protein_names_refseq": "fibronectin type 3 and ankyrin repeat domains 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:309071)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63207-1", "uniprot_id": "FA10_RAT", "mass": 54265.0, "length": 482, "protein_name": "Coagulation factor X", "gene_name": "F10", "organism": "Rat", "refseq_name": "coagulation factor X precursor", "refseq_ac": "NP_058839", "gene_names_uniprotkb": "F10", "gene_names_refseq": "F10", "protein_names_uniprotkb": "Coagulation factor X; 3.4.21.6; Stuart factor", "protein_names_refseq": "coagulation factor 10; coagulation factor X precursor; stuart factor", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); factor X deficiency (Disease Ontology:DOID:2222); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (rno:29243); (R-RNO-159740); (R-RNO-159763); (R-RNO-159782); (R-RNO-9769735); (R-RNO-9769739); (R-RNO-9769743)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "16807644;22999414;8578539", "class_list": "", "function": "Factor Xa inhibitor edoxaban at or higher doses than needed for an antithrombotic effect sustained the circulating Gla-osteocalcin level., [RefSeq, PubMed]; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (By similarity). Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.90;3.4.21.22;3.4.21.5;3.4.21.75;3.4.21.6;3.4.21.21", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0032008 positive regulation of TOR signaling;GO:0031638 zymogen activation;GO:0051239 regulation of multicellular organismal process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924T8-1", "uniprot_id": "CLTR1_RAT", "mass": 39143.0, "length": 339, "protein_name": "Cysteinyl leukotriene receptor 1", "gene_name": "Cysltr1", "organism": "Rat", "refseq_name": "cysteinyl leukotriene receptor 1", "refseq_ac": "NP_446093", "gene_names_uniprotkb": "Cysltr1; Cyslt1", "gene_names_refseq": "Cyslt1; Cysltr1", "protein_names_uniprotkb": "Cysteinyl leukotriene receptor 1; CysLTR1", "protein_names_refseq": "cysteinyl leukotriene receptor 1", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); respiratory allergy (Disease Ontology:DOID:0060496); acute asthma (Disease Ontology:DOID:0080810); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); allergic disease (Disease Ontology:DOID:1205); asthma (Disease Ontology:DOID:2841); pulmonary fibrosis (Disease Ontology:DOID:3770); rhinitis (Disease Ontology:DOID:4483); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:114099); (R-RNO-391906); (R-RNO-416476)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "27909742", "class_list": "", "function": "Cysteinyl leukotriene receptor-1 antagonist montelukast prevents estradiol-induced nonbacterial inflammation in the rat prostate., [RefSeq, PubMed]; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001631 cysteinyl leukotriene receptor activity;GO:0004974 leukotriene receptor activity;GO:0004966 galanin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:1903409 reactive oxygen species biosynthetic process;GO:0006935 chemotaxis;GO:0007166 cell surface receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q924T8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z122-1", "uniprot_id": "FADS2_RAT", "mass": 52380.0, "length": 444, "protein_name": "Acyl-CoA 6-desaturase", "gene_name": "Fads2", "organism": "Rat", "refseq_name": "acyl-CoA 6-desaturase", "refseq_ac": "NP_112634", "gene_names_uniprotkb": "Fads2; Fadsd6", "gene_names_refseq": "Fads2; Fadsd6", "protein_names_uniprotkb": "Acyl-CoA 6-desaturase; 1.14.19.3; D6D; Delta(6) desaturase; Delta(6) fatty acid desaturase; Delta-6 desaturase; Fatty acid desaturase 2", "protein_names_refseq": "D6D; acyl-CoA 6-desaturase; delta(6) desaturase; delta-6 fatty acid desaturase; fatty acid desaturase 6", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146); discrete subaortic stenosis (Disease Ontology:DOID:5804); congestive heart failure (Disease Ontology:DOID:6000); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:83512); (R-RNO-2046105); (R-RNO-2046106)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10049752;11988075;12538079;12562851;12562861;14563830;22216341;23107313;24070791;24284026;25046614;25701799;29735017;38843836;5094766", "class_list": "", "function": "Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure. Erratum:[Circ Heart Fail. 2014 Mar 1;7(2):382], [RefSeq, PubMed]; Delta6-desaturase acts on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis, [RefSeq, PubMed]; Epigenetic regulation of Fads2 may contribute to short- and long-term regulation of PUFA synthesis, [RefSeq, PubMed]; Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:10049752, PubMed:11988075, PubMed:14563830, PubMed:22216341, PubMed:24070791). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (PubMed:11988075). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (PubMed:24070791). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; N-6 and n-3 PUFAs suppressed the hepatic expression of Fads2 by inhibiting the rate of Fads2 gene transcription. In contrast, consumption of the PPARalpha activator WY 14,643 significantly enhanced the transcription of hepatic DeFads2 by 500%., [RefSeq, PubMed]; Rat Delta 6-desaturase, which acts on the 18- and 24-carbon fatty acids of the n-6 and n-3 series, is also able to catalyze palmitic acid Delta 6 -desaturation, [RefSeq, PubMed]; Results show that genes with the highest expression in the mammary gland, liver and adipose tissue were Elovl5, Fads2, and Fasn, respectively, in a low-lipid diet than in adequate-lipid diet., [RefSeq, PubMed]; The effect of dietary plant extracts and vegetable oils on hepatic SREBP-1c, Delta5 and Delta6 desaturases has been reported., [RefSeq, PubMed]; We first showed that both recombinant and native rat FADS2 were able to Delta6-desaturate not only the cis9- but also the cis12- and cis15-18:1 isomers., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "H2BF31", "ec_number_list": "1.14.19.3", "go_molecular_function": "GO:0045485 omega-6 fatty acid desaturase activity;GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0016213 acyl-CoA 6-desaturase activity;GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;GO:0016215 acyl-CoA desaturase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0042761 very long-chain fatty acid biosynthetic process;GO:1900409 positive regulation of cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z122-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXS7-1", "uniprot_id": "CMLO5_RAT", "mass": 25167.0, "length": 225, "protein_name": "Probable N-acetyltransferase family 8 member 5", "gene_name": "Nat8f5", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nat8f5; Cm15", "gene_names_refseq": "", "protein_names_uniprotkb": "Probable N-acetyltransferase family 8 member 5; 2.3.1.-; Camello-like protein 5; Probable N-acetyltransferase CML5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:114020)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11397015", "class_list": "", "function": "May play a role in regulation of gastrulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007507 heart development;GO:0001702 gastrulation with mouth forming second;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QXS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FQ8-1", "uniprot_id": "DLEC1_RAT", "mass": 52915.0, "length": 465, "protein_name": "Deleted in lung and esophageal cancer protein 1 homolog", "gene_name": "Dlec1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dlec1", "gene_names_refseq": "", "protein_names_uniprotkb": "Deleted in lung and esophageal cancer protein 1 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:501070)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential for spermatogenesis and male fertility (By similarity). May play an important role in sperm head and tail formation (By similarity). May act as a tumor suppressor by inhibiting cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0002357 defense response to tumor cell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64610-1", "uniprot_id": "ENPP2_RAT", "mass": 101576.0, "length": 887, "protein_name": "Autotaxin", "gene_name": "Enpp2", "organism": "Rat", "refseq_name": "autotaxin", "refseq_ac": "NP_476445", "gene_names_uniprotkb": "Enpp2; Atx; Npps2", "gene_names_refseq": "Enpp2", "protein_names_uniprotkb": "Autotaxin; 3.1.4.39; 3.1.4.4; E-NPP 2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Extracellular lysophospholipase D; LysoPLD", "protein_names_refseq": "E-NPP 2; autotaxin; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; extracellular lysophospholipase D; lysoPLD; phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin)", "tax_id": 10116, "disease": "proliferative diabetic retinopathy (Disease Ontology:DOID:13207)", "pathway": " (rno:84050)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12119361;12176993;12354767;12633853;15985467;16436050;21240271;27075612;27268273;27660691;28539367;29259743;29551679;35917632;7961762", "class_list": "", "function": "Autotaxin has lysophospholipase D activity. It suggests that autocrine or paracrine production of LPA contributes to tumor cell motility, survival, and proliferation, [RefSeq, PubMed]; ENPP2 protects cardiomyocytes from ferroptosis., [RefSeq, PubMed]; Immunohistochemical evaluation of autotaxin and lubricin in mild osteoarthritic rat model performing moderate physical activity., [RefSeq, PubMed]; Secreted lysophospholipase D that hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:12354767, PubMed:12633853, PubMed:27075612, PubMed:27268273, PubMed:27660691, PubMed:29259743). Its major substrate is lysophosphatidylcholine (PubMed:12119361, PubMed:12176993, PubMed:27075612, PubMed:27268273, PubMed:27660691). Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:12119361). Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:12633853, PubMed:27268273). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (By similarity). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The effects of gamma radiation on mRNA levels of autotaxin and 14 inflammatory mediators in adipose tissue and the consequences for radiation therapy and chemotherapy are discussed., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 10, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q66HQ0", "ec_number_list": "3.1.4.4;3.1.4.-;3.1.4.39", "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0004630 phospholipase D activity;GO:0005044 scavenger receptor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0030149 sphingolipid catabolic process;GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0048714 positive regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q64610-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XHY8-1", "uniprot_id": "F217A_RAT", "mass": 47054.0, "length": 419, "protein_name": "Protein FAM217A", "gene_name": "Fam217a", "organism": "Rat", "refseq_name": "protein FAM217A", "refseq_ac": "NP_001258012", "gene_names_uniprotkb": "Fam217a; LOC498735", "gene_names_refseq": "Fam217a", "protein_names_uniprotkb": "Protein FAM217A", "protein_names_refseq": "protein FAM217A; uncharacterized protein C6orf146 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:498735)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XHY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JK15-1", "uniprot_id": "ADAP2_RAT", "mass": 43524.0, "length": 376, "protein_name": "Arf-GAP with dual PH domain-containing protein 2", "gene_name": "Adap2", "organism": "Rat", "refseq_name": "arf-GAP with dual PH domain-containing protein 2", "refseq_ac": "NP_064486", "gene_names_uniprotkb": "Adap2; Centa2", "gene_names_refseq": "Adap2; Centa2", "protein_names_uniprotkb": "Arf-GAP with dual PH domain-containing protein 2; Centaurin-alpha-2; Cnt-a2", "protein_names_refseq": "Centaurin-alpha2 protein; arf-GAP with dual PH domain-containing protein 2; centaurin-alpha-2; cnt-a2", "tax_id": 10116, "disease": "", "pathway": " (rno:56826)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12018390", "class_list": "", "function": "GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Binding of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4-bisphosphate occurs at a much lower affinity. Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity)., [UniProtKB]; Results describe the cloning, expression and characterisation of centaurin-alpha2 from a rat adipocyte cDNA library., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005740 mitochondrial envelope;GO:0005886 plasma membrane", "go_biological_process": "GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JK15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPW1-1", "uniprot_id": "BMAL1_RAT", "mass": 68616.0, "length": 626, "protein_name": "Basic helix-loop-helix ARNT-like protein 1", "gene_name": "Bmal1", "organism": "Rat", "refseq_name": "basic helix-loop-helix ARNT-like protein 1", "refseq_ac": "NP_077338", "gene_names_uniprotkb": "Bmal1; Arntl; Tic", "gene_names_refseq": "Arntl; Bmal1", "protein_names_uniprotkb": "Basic helix-loop-helix ARNT-like protein 1; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Brain and muscle ARNT-like 1; Tic", "protein_names_refseq": "aryl hydrocarbon receptor nuclear translocator-like protein 1; basic helix-loop-helix ARNT-like protein 1; brain and muscle ARNT-like 1; tic", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cholestasis (Disease Ontology:DOID:13580); bipolar disorder (Disease Ontology:DOID:3312); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:29657); (R-RNO-9768919)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "22356123;23337503;23596172;37356134;37381033;38035406;38597076;38678672;9585435;9735336", "class_list": "", "function": "BMAL1 alleviates myocardial damage in sepsis by activating SIRT1 signaling and promoting mitochondrial autophagy., [RefSeq, PubMed]; Bmal1 downregulation leads to diabetic cardiomyopathy by promoting Bcl2/IP3R-mediated mitochondrial Ca[2+] overload., [RefSeq, PubMed]; Impact of circadian clock protein Bmal1 on experimentally-induced periodontitis-associated renal injury., [RefSeq, PubMed]; Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression., [RefSeq, PubMed]; The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. [provided by RefSeq, Jan 2014]., [RefSeq]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. May play a role in spermatogenesis; contributes to the chromatoid body assembly and physiology. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (By similarity). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (By similarity). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3'. Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (By similarity). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA and Melatonin in Insomnia Rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88337;O88810;Q499M8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0017162 aryl hydrocarbon receptor binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:1901985 positive regulation of protein acetylation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9EPW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64678-1", "uniprot_id": "CP1B1_RAT", "mass": 60557.0, "length": 543, "protein_name": "Cytochrome P450 1B1", "gene_name": "Cyp1b1", "organism": "Rat", "refseq_name": "cytochrome P450 1B1", "refseq_ac": "NP_037072", "gene_names_uniprotkb": "Cyp1b1", "gene_names_refseq": "Cyp1b1", "protein_names_uniprotkb": "Cytochrome P450 1B1; 1.14.14.1; 4.2.1.152; CYPIB1; Cytochrome P450RAP; Hydroperoxy icosatetraenoate dehydratase", "protein_names_refseq": "CYPIB1; P450RAP; cytochrome P450 1B1; cytochrome P450, subfamily 1B, polypeptide 1; cytochrome P450RAP; hydroperoxy icosatetraenoate dehydratase", "tax_id": 10116, "disease": "Peters anomaly (Disease Ontology:DOID:0060673); anterior segment dysgenesis 6 (Disease Ontology:DOID:0080611); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); buphthalmos (Disease Ontology:DOID:11211); hydrophthalmos (Disease Ontology:DOID:11212); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leiomyoma (Disease Ontology:DOID:127); breast cancer (Disease Ontology:DOID:1612); breast adenocarcinoma (Disease Ontology:DOID:3458); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:25426); (R-RNO-211976); (R-RNO-2142670); (R-RNO-2142816)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "20972997;21785971;21867498;23026235;23821647;33170892;33389498;33766215;35054909;37961023;7744798;7788849", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (By similarity). Exhibits catalytic activity for the formation of hydroxyestrogens from 17beta-estradiol (E2), namely 2- and 4-hydroxy E2 (PubMed:23821647). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (By similarity). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (By similarity). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed:20972997). Additionally, displays dehydratase activity toward oxygenated eicosanoids including hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (By similarity). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (By similarity). Plays an important role in retinal vascular development. Under ambient/hyperoxic O2 conditions, promotes angiogenesis and capillary morphogenesis of retinal endothelial cells and pericytes, likely by metabolizing the oxygenated products symptomatic of oxidative stress (By similarity). Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium., [RefSeq, PubMed]; Hippocampal Expression of Cytochrome P450 1B1 in Penetrating Traumatic Brain Injury. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate myocardial infarction in a PBX3/CYP1B1-dependent manner., [RefSeq, PubMed]; MiR-488-3p facilitates wound healing through CYP1B1-mediated Wnt/beta-catenin signaling pathway by targeting MeCP2., [RefSeq, PubMed]; The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu). Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;1.14.14.25;4.2.1.152;5.4.4.7;1.14.13.n7;1.14.14.94;5.3.99.5;1.14.14.80;5.3.99.4", "go_molecular_function": "GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002930 trabecular meshwork development;GO:0008210 estrogen metabolic process;GO:0071603 endothelial cell-cell adhesion;GO:0071680 response to indole-3-methanol;GO:1904681 response to 3-methylcholanthrene", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q64678-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R508-1", "uniprot_id": "FAT3_RAT", "mass": 502088.0, "length": 4555, "protein_name": "Protocadherin Fat 3", "gene_name": "Fat3", "organism": "Rat", "refseq_name": "protocadherin Fat 3 isoform 2 precursor", "refseq_ac": "NP_612553", "gene_names_uniprotkb": "Fat3", "gene_names_refseq": "Fat3", "protein_names_uniprotkb": "Protocadherin Fat 3; FAT tumor suppressor homolog 3", "protein_names_refseq": "FAT tumor suppressor homolog 3; Fta3 protein; protocadherin Fat 3 isoform 2 precursor; protocadherin Fat 3", "tax_id": 10116, "disease": "", "pathway": " (rno:191571)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11811999;38843836", "class_list": "", "function": "May play a role in the interactions between neurites derived from specific subsets of neurons during development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 26, "predicted_n_glycosites": 26, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 26, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0030425 dendrite", "go_biological_process": "GO:0016358 dendrite development;GO:0001764 neuron migration;GO:0000902 cell morphogenesis;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0010842 retina layer formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R508-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3V3-1", "uniprot_id": "AGRG1_RAT", "mass": 77252.0, "length": 687, "protein_name": "Adhesion G protein-coupled receptor G1", "gene_name": "Adgrg1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Adgrg1; Gpr56", "gene_names_refseq": "", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor G1; ADGRG1 C-terminal fragment; ADGRG1 CT; ADGRG1 N-terminal fragment; ADGRG1 NT; G protein-coupled receptor 56; GPR56 7TM; GPR56 C-terminal fragment; GPR56 CT; GPR56 N-terminal fragment; GPR56 NT; GPR56 extracellular subunit; GPR56 seven-transmembrane subunit; GPR56 subunit alpha; GPR56 subunit beta; GPR56(C); GPR56(N)", "protein_names_refseq": "", "tax_id": 10116, "disease": "complex cortical dysplasia with other brain malformations 14A (Disease Ontology:DOID:0080922); complex cortical dysplasia with other brain malformations 14B (Disease Ontology:DOID:0080924)", "pathway": " (rno:260326)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21708946;22673903;24090084;29393594;38843836", "class_list": "", "function": "Adhesion G protein-coupled receptor (aGPCR) for steroid hormone 17alpha-hydroxypregnenolone (17-OH), which is involved in cell adhesion and cell-cell interactions. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway. ADGRG1 is coupled to G(12) and/or G(13) G proteins (GNA12 and GNA13, respectively) and mediates the activation Rho small GTPases (By similarity). Acts as a potent suppressor of ferroptosis: binding to 17-OH-binding initiates signaling that down-regulates CD36 and alleviates ferroptosis-induced liver injury. Ligand-binding also induces cell adhesion activity via association with proteins such as collagen III/COL3A1 and TGM2. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells (By similarity). Involved in cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination: association with COL3A1 in the developing brain inhibits neuronal migration via activation of the RhoA pathway (By similarity). Together with TGM2, acts as a regulator of myelination and myelin repair in oligodendrocyte precursor cells (By similarity). Acts as a hemostatic sensor of shear force: G protein-coupled receptor signaling is activated in response to shear force in platelets, promoting G(13) G protein signaling, and platelet shape change and aggregation in a COL3A1-dependent manner. Acts as an inhibitor of VEGFA production thereby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (By similarity). Plays a role in the maintenance of hematopoietic stem cells in bone marrow niche. Plays an essential role in testis development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008201 heparin binding;GO:0005518 collagen binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0097451 glial limiting end-foot", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K3V3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CJ58-1", "uniprot_id": "CLRN1_RAT", "mass": 25782.0, "length": 232, "protein_name": "Clarin-1", "gene_name": "Clrn1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Clrn1; Ush3a", "gene_names_refseq": "", "protein_names_uniprotkb": "Clarin-1; Usher syndrome type-3 protein homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "Usher syndrome (Disease Ontology:DOID:0050439); retinitis pigmentosa 61 (Disease Ontology:DOID:0110373); Usher syndrome type 3 (Disease Ontology:DOID:0110828); Usher syndrome type 3A (Disease Ontology:DOID:0110841); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:261738)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12145752", "class_list": "", "function": "May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0045178 basal part of cell;GO:0015630 microtubule cytoskeleton;GO:0005902 microvillus", "go_biological_process": "GO:0007015 actin filament organization;GO:0050885 neuromuscular process controlling balance;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CJ58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYQ2-1", "uniprot_id": "AK1CL_RAT", "mass": 36135.0, "length": 318, "protein_name": "Aldo-keto reductase family 1 member C21", "gene_name": "Akr1c21; Akr1c2", "organism": "Rat", "refseq_name": "aldo-keto reductase family 1 member C21 isoform 3", "refseq_ac": "NP_001013075", "gene_names_uniprotkb": "Akr1c21; Akr1c2", "gene_names_refseq": "Akr1c21; Akr1c2; RAKg", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member C21; 1.1.1.-; 1.1.1.209; 17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase", "protein_names_refseq": "17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3(17)alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase; aldo-keto reductase family 1 member C21 isoform 3; aldo-keto reductase family 1, member C21", "tax_id": 10116, "disease": "46,XY sex reversal 8 (Disease Ontology:DOID:0111773); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:291283); (R-RNO-193368); (R-RNO-193775); (R-RNO-193807); (R-RNO-2162123); (R-RNO-5365859); (R-RNO-975634); (R-RNO-9757110)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3-alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17-ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3-ketosteroids yields only 3-alpha-hydroxysteroids (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.62;1.1.1.239;1.1.1.105;1.1.1.209;1.1.1.53;1.1.1.50;1.1.1.315;1.1.1.149;1.1.-.-;1.1.1.21;1.1.1.-", "go_molecular_function": "GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0004032 aldose reductase (NADPH) activity;GO:0031406 carboxylic acid binding;GO:0005496 steroid binding;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0030855 epithelial cell differentiation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76LD0-1", "uniprot_id": "CRDL1_RAT", "mass": 50560.0, "length": 447, "protein_name": "Chordin-like protein 1", "gene_name": "Chrdl1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Chrdl1; Kjr; Ng1", "gene_names_refseq": "", "protein_names_uniprotkb": "Chordin-like protein 1; Kohjirin; Neuralin-1; Neurogenesin-1; Ventroptin", "protein_names_refseq": "", "tax_id": 10116, "disease": "megalocornea (Disease Ontology:DOID:0060305)", "pathway": " (rno:363455); (R-RNO-201451); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "14684875", "class_list": "", "function": "Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. Plays a role during anterior segment eye development (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050431 transforming growth factor beta binding;GO:0036122 BMP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0098976 excitatory chemical synaptic transmission;GO:0030154 cell differentiation;GO:0048167 regulation of synaptic plasticity;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q76LD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FV5-1", "uniprot_id": "GAR1B_RAT", "mass": 38996.0, "length": 344, "protein_name": "Golgi-associated RAB2 interactor protein 1B", "gene_name": "Garin1b", "organism": "Rat", "refseq_name": "Golgi-associated RAB2 interactor protein 1B isoform 1", "refseq_ac": "NP_001019495", "gene_names_uniprotkb": "Garin1b; Fam137a; Fam71f1", "gene_names_refseq": "Fam71f1; Garin1b; Tdrns18l1", "protein_names_uniprotkb": "Golgi-associated RAB2 interactor protein 1B", "protein_names_refseq": "Golgi associated RAB2 interactor protein 1B; Golgi-associated RAB2 interactor protein 1B isoform 1; family with sequence similarity 71, member F1; protein FAM71F1", "tax_id": 10116, "disease": "", "pathway": " (rno:500061)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RAB2B effector protein required for accurate acrosome formation and normal male fertility. In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007340 acrosome reaction;GO:0001675 acrosome assembly;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4V2-1", "uniprot_id": "B3A4_RAT", "mass": 105320.0, "length": 953, "protein_name": "Anion exchange protein 4", "gene_name": "Slc4a9", "organism": "Rat", "refseq_name": "anion exchange protein 4", "refseq_ac": "NP_690921", "gene_names_uniprotkb": "Slc4a9; Ae4", "gene_names_refseq": "Ae4; Slc4a9", "protein_names_uniprotkb": "Anion exchange protein 4; AE 4; Anion exchanger 4; Solute carrier family 4 member 9", "protein_names_refseq": "AE 4; anion exchange protein 4; anion exchanger 4; solute carrier family 4, sodium bicarbonate cotransporter, member 9", "tax_id": 10116, "disease": "anemia (Disease Ontology:DOID:2355)", "pathway": " (rno:266612); (R-RNO-425381)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12225984", "class_list": "", "function": "Electroneutral Cl(-)/HCO3(-) antiporter that favors chloride ion entry and efflux of hydrogencarbonate and sodium ion across the basolateral membrane and may participate in salivary secretion (PubMed:12225984). Also mediates Cl(-)/HCO3(-) exchange activity in the presence of K(+) as well as Cs(+), Li(+), and Rb(+). Does not contribute to Cl(-)/HCO3(-) exchanger in the apical membrane of the upper villous epithelium (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008510 sodium:bicarbonate symporter activity;GO:0140892 sodium,bicarbonate:chloride antiporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0046541 saliva secretion;GO:0055085 transmembrane transport;GO:0035725 sodium ion transmembrane transport;GO:0015701 bicarbonate transport;GO:0006820 monoatomic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K4V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0U5-1", "uniprot_id": "AOXA_RAT", "mass": 146921.0, "length": 1333, "protein_name": "Aldehyde oxidase 1", "gene_name": "Aox1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Aox1; Ao", "gene_names_refseq": "", "protein_names_uniprotkb": "Aldehyde oxidase 1; 1.17.3.-; 1.2.3.1; Azaheterocycle hydroxylase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "xanthinuria (Disease Ontology:DOID:0060236); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (rno:54349); (R-RNO-964975)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17353002;19801639;23263164;23282065;9224775;9920943", "class_list": "", "function": "Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. Is a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also catalyzes nitric oxide (NO) production; under anaerobic conditions, reduces nitrite to NO with NADH or aldehyde as electron donor, but under aerobic conditions, NADH is the preferred substrate. These reactions may be catalyzed by several isozymes. May play a role in adipogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R240", "ec_number_list": "1.17.3.-;1.2.3.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0006629 lipid metabolic process;GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z0U5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924K2-1", "uniprot_id": "FAF1_RAT", "mass": 73745.0, "length": 649, "protein_name": "FAS-associated factor 1", "gene_name": "Faf1", "organism": "Rat", "refseq_name": "FAS-associated factor 1", "refseq_ac": "NP_569090", "gene_names_uniprotkb": "Faf1", "gene_names_refseq": "Faf1", "protein_names_uniprotkb": "FAS-associated factor 1", "protein_names_refseq": "FAS-associated factor 1; Fas (TNFRSF6) associated factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:140657)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;33510836", "class_list": "", "function": "Fas-Associated Factor 1 Promotes Hepatic Insulin Resistance via JNK Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:0006915 apoptotic process;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0045732 positive regulation of protein catabolic process;GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q924K2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQH1-1", "uniprot_id": "GAB2_RAT", "mass": 73328.0, "length": 665, "protein_name": "GRB2-associated-binding protein 2", "gene_name": "Gab2", "organism": "Rat", "refseq_name": "GRB2-associated-binding protein 2", "refseq_ac": "NP_445869", "gene_names_uniprotkb": "Gab2", "gene_names_refseq": "Gab2", "protein_names_uniprotkb": "GRB2-associated-binding protein 2; GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2", "protein_names_refseq": "GRB2-associated binder 2; GRB2-associated-binding protein 2; growth factor receptor bound protein 2-associated protein 2", "tax_id": 10116, "disease": "chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (rno:84477); (R-RNO-109704); (R-RNO-1257604); (R-RNO-1433557); (R-RNO-2730905); (R-RNO-6811558); (R-RNO-8853659); (R-RNO-912526); (R-RNO-9607240); (R-RNO-9674555)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "11701952;12595575;19118509;22673903;23045700", "class_list": "", "function": "Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis (By similarity)., [UniProtKB]; Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat, [RefSeq, PubMed]; Gab2 siRNA could suppress the antigen-induced activation of RBL-2H3 cells and suggested a possible mechanism through inhibition of signaling molecules downstream of Gab2 in the FcepsilonRI-mediated Ca(2+)-independent pathway., [RefSeq, PubMed]; Gab2 tyrosine phosphorylation; role in epidermal growth factor-induced mitogenesis, [RefSeq, PubMed]; Overexpression of GAB2 enhances FSH-stimulated AKT phosphorylation. GAB2, thus, seems to coordinate signals from the FSH-stimulated rise in cAMP that leads to activation of PI3K/AKT, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019904 protein domain specific binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0019903 protein phosphatase binding;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007165 signal transduction;GO:0007229 integrin-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EQH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63072-1", "uniprot_id": "BST1_RAT", "mass": 35131.0, "length": 319, "protein_name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2", "gene_name": "Bst1", "organism": "Rat", "refseq_name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor", "refseq_ac": "NP_110475", "gene_names_uniprotkb": "Bst1", "gene_names_refseq": "Bst1", "protein_names_uniprotkb": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; 3.2.2.6; ADP-ribosyl cyclase 2; BST-1; Bone marrow stromal antigen 1; Cyclic ADP-ribose hydrolase 2; cADPR hydrolase 2", "protein_names_refseq": "ADP-ribosyl cyclase 2; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; BST-1; bone marrow stromal antigen 1; cADPr hydrolase 2; cyclic ADP-ribose hydrolase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:81506); (R-RNO-163125); (R-RNO-196807); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8522202", "class_list": "", "function": "Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium. May be involved in pre-B-cell growth., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;7.6.2.1;2.4.2.31;3.1.3.1;3.2.2.-;3.2.2.6;3.6.5.2;2.3.1.51;2.7.11.1;3.9.1.1;3.2.2.5;1.14.14.18;3.4.21.73;1.1.1.-;3.1.4.4;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.3.2.27;3.5.1.92;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;1.14.19.17;5.2.1.-;2.4.99.20;3.1.4.50;3.4.11.9;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0016740 transferase activity;GO:0016849 phosphorus-oxygen lyase activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001931 uropod;GO:0098552 side of membrane;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0032956 regulation of actin cytoskeleton organization;GO:0030890 positive regulation of B cell proliferation;GO:0050727 regulation of inflammatory response;GO:0001952 regulation of cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63072-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIY2-1", "uniprot_id": "DUOX1_RAT", "mass": 177197.0, "length": 1551, "protein_name": "Dual oxidase 1", "gene_name": "Duox1", "organism": "Rat", "refseq_name": "dual oxidase 1 precursor", "refseq_ac": "NP_714961", "gene_names_uniprotkb": "Duox1", "gene_names_refseq": "Duox1", "protein_names_uniprotkb": "Dual oxidase 1; 1.-.-.-; 1.11.1.-; 1.6.3.1", "protein_names_refseq": "dual oxidase 1 precursor", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); primary bacterial infectious disease (Disease Ontology:DOID:0050338); hypothyroidism (Disease Ontology:DOID:1459); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (rno:266807); (R-RNO-209968)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10806195;12538618;17643428;32712621", "class_list": "", "function": "Generates hydrogen peroxide (H2O2) which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO (PubMed:17643428). Plays a role in thyroid hormone synthesis (By similarity). Also required for lactoperoxidase-mediated antimicrobial defense at the surface of mucosa (By similarity). Antimicrobial agent hypothiocyanite (OSCN-), which is produced by LPO from DUOX1-derived H2O2, promotes influenza virus inactivation by reducing viral binding to and entry into host cells (By similarity). Promotes antiviral immunity by increasing airway cytokine levels, promoting innate immune cell recruitment and reducing airway epithelial cell apoptosis (By similarity). In response to bacterial stimuli, activated by ATP and promotes EGFR/ERK signaling, ADAM17 activation, and EGFR ligand shedding, leading to enhanced CXCL8/IL8 expression and secretion in airway epithelia (By similarity). Synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation (By similarity). In addition to its oxidase activity, has also been shown to have peroxidase activity through its N-terminal peroxidase-like domain (By similarity). However, another study showed that the isolated peroxidase-like domain does not bind heme and has no intrinsic peroxidase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Vitamin D Attenuates Hypoxia-Induced Injury in Rat Primary Neuron Cells through Downregulation of the Dual Oxidase 1 (DUOX1) Gene. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.6.3.1;1.14.13.225;1.-.-.-;1.11.1.8;1.6.99.1;1.11.1.-;1.14.13.8", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0071949 FAD binding;GO:0005509 calcium ion binding;GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031252 cell leading edge", "go_biological_process": "GO:0042335 cuticle development;GO:0006952 defense response;GO:0006979 response to oxidative stress;GO:0090303 positive regulation of wound healing;GO:0042446 hormone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CIY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63202-1", "uniprot_id": "ADAM2_RAT", "mass": 82311.0, "length": 737, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 2", "gene_name": "Adam2", "organism": "Rat", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 2 precursor", "refseq_ac": "NP_064462", "gene_names_uniprotkb": "Adam2; Ftnb", "gene_names_refseq": "Adam2; Ftnb; PH-30", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 2; ADAM 2; Fertilin subunit beta; PH-30; PH30-beta; PH30", "protein_names_refseq": "A disintegrin and metalloprotease domain 2 (Fertilin beta); ADAM 2; PH30-beta; PH30; a disintegrin and metallopeptidase domain 2; a disintegrin and metalloprotease domain (ADAM) 2; disintegrin and metalloproteinase domain-containing protein 2 precursor; disintegrin and metalloproteinase domain-containing protein 2; fertilin beta; fertilin subunit beta", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:56806)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;30396079;9358007", "class_list": "", "function": "ADAM2 silencing alleviates isoflurane-induced cognitive dysfunction by activating the PI3K/Akt signal pathway., [RefSeq, PubMed]; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0001669 acrosomal vesicle;GO:0032991 protein-containing complex;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0007283 spermatogenesis;GO:0007339 binding of sperm to zona pellucida;GO:0008542 visual learning", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63202-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62956-1", "uniprot_id": "ERBB4_RAT", "mass": 146958.0, "length": 1308, "protein_name": "Receptor tyrosine-protein kinase erbB-4", "gene_name": "Erbb4", "organism": "Rat", "refseq_name": "receptor tyrosine-protein kinase erbB-4 isoform 2 precursor", "refseq_ac": "NP_067719", "gene_names_uniprotkb": "Erbb4; Tyro-2", "gene_names_refseq": "Erbb4", "protein_names_uniprotkb": "Receptor tyrosine-protein kinase erbB-4; 2.7.10.1; Proto-oncogene-like protein c-ErbB-4; s80HER4", "protein_names_refseq": "c-erbB-4; proto-oncogene-like protein c-ErbB-4; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-4 isoform 2 precursor; receptor tyrosine-protein kinase erbB-4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene 4", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); amyotrophic lateral sclerosis type 19 (Disease Ontology:DOID:0060210); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); urinary bladder cancer (Disease Ontology:DOID:11054); interstitial cystitis (Disease Ontology:DOID:13949); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carcinoma (Disease Ontology:DOID:305); bipolar disorder (Disease Ontology:DOID:3312); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); radiculopathy (Disease Ontology:DOID:4306); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419); stomach carcinoma (Disease Ontology:DOID:5517); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); median neuropathy (Disease Ontology:DOID:571); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:59323)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10839362;12716924;14654373;15355992;17250808;17521571;2025425;34273906;35370955;36584915;38843836;9030624;9553078", "class_list": "", "function": "Effect of regulation of the NRG1/ErbB4 signaling pathway on the visual cortex synaptic plasticity of amblyopic adult rats., [RefSeq, PubMed]; MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats. Publication Status: Online-Only, [RefSeq, PubMed]; MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPbeta modification in rats., [RefSeq, PubMed]; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 32, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q6UA28;Q6UA29;Q9Z2N7", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.10.2;2.7.12.2;2.7.1.40;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.32;2.7.1.82;2.7.11.23", "go_molecular_function": "GO:0038131 neuregulin receptor activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0021551 central nervous system morphogenesis;GO:0061026 cardiac muscle tissue regeneration;GO:0072046 establishment of planar polarity involved in nephron morphogenesis;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q62956-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DTM3-1", "uniprot_id": "AHI1_RAT", "mass": 119687.0, "length": 1047, "protein_name": "Jouberin", "gene_name": "Ahi1", "organism": "Rat", "refseq_name": "jouberin", "refseq_ac": "NP_001002277", "gene_names_uniprotkb": "Ahi1", "gene_names_refseq": "Ahi-1; Ahi1", "protein_names_uniprotkb": "Jouberin; AHI-1; Abelson helper integration site 1 protein homolog", "protein_names_refseq": "abelson helper integration site 1 protein homolog; jouberin-like; jouberin", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Joubert syndrome 3 (Disease Ontology:DOID:0110998); Joubert syndrome 4 (Disease Ontology:DOID:0110999); nephronophthisis (Disease Ontology:DOID:12712); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:308923); (R-RNO-5620912)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12186888;22673903", "class_list": "", "function": "Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0005929 cilium;GO:0005814 centriole", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010628 positive regulation of gene expression;GO:0010976 positive regulation of neuron projection development;GO:0021510 spinal cord development;GO:0034329 cell junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DTM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHK0-1", "uniprot_id": "ACOT8_RAT", "mass": 36003.0, "length": 320, "protein_name": "Acyl-coenzyme A thioesterase 8", "gene_name": "Acot8", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Acot8; Pte1", "gene_names_refseq": "", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase 8; 3.1.2.11; 3.1.2.1; 3.1.2.27; 3.1.2.2; 3.1.2.3; 3.1.2.5; Acyl-CoA thioesterase 8; Choloyl-coenzyme A thioesterase; PTE-1; Peroxisomal acyl-coenzyme A thioester hydrolase 1; Peroxisomal long-chain acyl-CoA thioesterase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:170588); (R-RNO-193368); (R-RNO-2046106); (R-RNO-389887); (R-RNO-390247); (R-RNO-9033241)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "10092594;11785945", "class_list": "", "function": "Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:11785945). Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:11785945). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.3.15;1.2.3.5;3.4.21.-;3.1.2.2;2.3.2.27;1.4.3.1;3.5.2.6;1.4.3.3;3.1.2.-;1.11.1.6;1.3.3.6;3.1.2.14;2.6.1.51;2.6.1.44;2.3.1.137;2.3.1.176;2.3.1.16;2.3.1.155;3.1.2.1;2.3.1.9;2.3.2.36;2.5.1.18;3.4.24.56;1.1.1.42;3.1.2.22;5.1.99.4;4.1.3.4;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.1.4;3.1.1.5;1.14.13.39;3.4.21.53;5.3.3.8;5.3.3.21;3.1.2.27;2.3.1.65;3.6.1.-;3.6.1.77;2.3.1.7;4.1.2.63;3.1.2.11;3.1.2.3;3.1.2.5;1.1.1.300;1.1.1.184;4.1.1.9;2.3.1.42;1.3.1.38;2.7.4.6;1.3.1.124", "go_molecular_function": "GO:0003986 acetyl-CoA hydrolase activity;GO:0004778 succinyl-CoA hydrolase activity;GO:0033882 choloyl-CoA hydrolase activity;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0009062 fatty acid catabolic process;GO:0016559 peroxisome fission;GO:0043649 dicarboxylic acid catabolic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VHK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64581-1", "uniprot_id": "CP3AI_RAT", "mass": 57307.0, "length": 497, "protein_name": "Cytochrome P450 3A18", "gene_name": "Cyp3a18", "organism": "Rat", "refseq_name": "cytochrome P450 3A18", "refseq_ac": "NP_665725", "gene_names_uniprotkb": "Cyp3a18", "gene_names_refseq": "Cyp3a18", "protein_names_uniprotkb": "Cytochrome P450 3A18; 1.14.14.1; CYPIIIA18; Cytochrome P450(6)beta-2", "protein_names_refseq": "CYPIIIA18; cytochrome P450 3A18; cytochrome P450(6)beta-2; cytochrome P450, 3a18", "tax_id": 10116, "disease": "", "pathway": " (rno:252931); (R-RNO-211945); (R-RNO-211958); (R-RNO-211981); (R-RNO-5423646); (R-RNO-9027307); (R-RNO-9749641); (R-RNO-9754706); (R-RNO-9757110)", "pathway_count": 9, "publication_count": 2, "publication_id_list": "7873612;8845857", "class_list": "", "function": "Catalyzes 16-beta- and 6-alpha-hydroxylations of testosterone., [UniProtKB]; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0050649 testosterone 6-beta-hydroxylase activity;GO:0008390 testosterone 16-alpha-hydroxylase activity;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070989 oxidative demethylation;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64581-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VII2-1", "uniprot_id": "CST12_RAT", "mass": 15152.0, "length": 128, "protein_name": "Cystatin-12", "gene_name": "Cst12", "organism": "Rat", "refseq_name": "cystatin-12", "refseq_ac": "NP_714956", "gene_names_uniprotkb": "Cst12", "gene_names_refseq": "Cst12", "protein_names_uniprotkb": "Cystatin-12; Cystatin TE-1", "protein_names_refseq": "cystatin TE-1; cystatin-12", "tax_id": 10116, "disease": "", "pathway": " (rno:266776)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12444065", "class_list": "", "function": "May play a specialized role in spermatogenesis., [UniProtKB]; Unusual amino acid sequence and highly restricted expression suggests that cystatins SC and TE-1 play a very specialized role in the testis and epididymis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VII2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62799-1", "uniprot_id": "ERBB3_RAT", "mass": 147546.0, "length": 1339, "protein_name": "Receptor tyrosine-protein kinase erbB-3", "gene_name": "Erbb3", "organism": "Rat", "refseq_name": "receptor tyrosine-protein kinase erbB-3 precursor", "refseq_ac": "NP_058914", "gene_names_uniprotkb": "Erbb3", "gene_names_refseq": "Erbb3; nuc-ErbB3", "protein_names_uniprotkb": "Receptor tyrosine-protein kinase erbB-3; 2.7.10.1; Proto-oncogene-like protein c-ErbB-3", "protein_names_refseq": "avian erythroblastosis oncogene B 3; c-erbB-3; c-erbB3; proto-oncogene-like protein c-ErbB-3; receptor tyrosine-protein kinase erbB-3 precursor; receptor tyrosine-protein kinase erbB-3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); ductal carcinoma in situ (Disease Ontology:DOID:0060074); lethal congenital contracture syndrome 2 (Disease Ontology:DOID:0060560); neuronal intestinal dysplasia type A (Disease Ontology:DOID:0080679); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); urinary bladder cancer (Disease Ontology:DOID:11054); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carcinoma (Disease Ontology:DOID:305); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); stomach carcinoma (Disease Ontology:DOID:5517); median neuropathy (Disease Ontology:DOID:571); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:29496); (R-RNO-1227986); (R-RNO-1236394); (R-RNO-1250196); (R-RNO-1257604); (R-RNO-1306955); (R-RNO-1358803); (R-RNO-1963642); (R-RNO-5673001); (R-RNO-6785631); (R-RNO-6811558); (R-RNO-8847993); (R-RNO-8863795)", "pathway_count": 13, "publication_count": 7, "publication_id_list": "12824184;22673903;31669265;32200526;33640362;8522190;9030624", "class_list": "", "function": "Differentially expressed genes accompanying neurobehavioral deficits in a modified rat model of vascular dementia., [RefSeq, PubMed]; Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3., [RefSeq, PubMed]; Treatment of neonatal rats with rhNRG-1 induced a signaling response comparable with that observed in vitro, including increased ErbB4-pTyr(1284), Akt-pThr(308) and Erk1/2-pThr(202)/Tyr(204)., [RefSeq, PubMed]; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q62955", "ec_number_list": "2.7.12.1;2.7.10.1;2.7.11.1;2.7.1.153;2.7.1.137;2.7.10.2;3.1.3.48;2.7.1.154;2.7.12.2;2.7.1.40;2.3.2.27;3.6.5.2;2.7.11.17;2.7.11.13;2.7.10.4;3.6.4.10;2.7.1.32;2.7.1.82;3.2.2.6;2.7.11.23;3.2.1.31", "go_molecular_function": "GO:0038131 neuregulin receptor activity;GO:0038132 neuregulin binding;GO:0004888 transmembrane signaling receptor activity;GO:0005524 ATP binding;GO:0019838 growth factor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body;GO:0043235 receptor complex", "go_biological_process": "GO:0021545 cranial nerve development;GO:0038127 ERBB signaling pathway;GO:0007162 negative regulation of cell adhesion;GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62799-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62630-1", "uniprot_id": "EGLN3_RAT", "mass": 27242.0, "length": 239, "protein_name": "Prolyl hydroxylase EGLN3", "gene_name": "Egln3", "organism": "Rat", "refseq_name": "prolyl hydroxylase EGLN3", "refseq_ac": "NP_062244", "gene_names_uniprotkb": "Egln3; Sm20", "gene_names_refseq": "Egln3; PHD-3; PHD3; SM-20", "protein_names_uniprotkb": "Prolyl hydroxylase EGLN3; 1.14.11.-; 1.14.11.29; Egl nine homolog 3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; Hypoxia-inducible factor prolyl hydroxylase 3; PHD3; Prolyl hydroxylase domain-containing protein 3; SM-20", "protein_names_refseq": "HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; egl nine homolog 3, mitochondrial; factor-responsive smooth muscle protein; hypoxia-inducible factor prolyl hydroxylase 3; prolyl hydroxylase EGLN3; prolyl hydroxylase domain-containing protein 3", "tax_id": 10116, "disease": "acute kidney failure (Disease Ontology:DOID:3021); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:54702); (R-RNO-1234176)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10386996;11060309;11595184;15081411;16407229;16765982;20849813;25633836;26108712;32123074;8175725", "class_list": "", "function": "24 h after HI, there was a significant increase in PHD3 protein and an increase of HIF-1alpha compared to controls, [RefSeq, PubMed]; Depletion of PHD3 leads to increased stabilization of HIF-1alpha and inhibition of DNA damage response, both of which may contribute to the cardioprotective effect seen with depletion of PHD3., [RefSeq, PubMed]; In a dietary Zn deficiency-promoted rat esophageal squamous cell carcinoma (ESCC) model with miR-31-controlled inflammation pathway up-regulation, systemic antimiR-31 suppressed ESCC development. Egln3 was identified as a direct miR-31 target. miR-31 genetic knockout prevents Zn deficiency-associated ESCC by eliminating or greatly reducing the entire miR-31-EGLN3/STK40-NF-kappaB-controlled inflammatory process., [RefSeq, PubMed]; Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as PKM, TELO2, ATF4, GPX4 and HIF1A (By similarity). Target proteins are preferentially recognized via a LXXLAP motif (By similarity). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (By similarity). Also hydroxylates HIF2A (By similarity). Has a preference for the CODD site for both HIF1A and HIF2A (By similarity). Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site (By similarity). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (By similarity). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (By similarity). Acts as an inhibitor of ferroptosis by mediating hydroxylation of GPX4, thereby preventing GPX4 degradation via chaperone-mediated autophagy (By similarity). GPX4 hydroxylation is promoted by PSAT1, which provides 2-oxoglutarate substrate to EGLN3 (By similarity). ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia (By similarity). Also hydroxylates PKM in hypoxia, limiting glycolysis (By similarity). Under normoxia, hydroxylates and regulates the stability of ADRB2 (By similarity). Regulator of cardiomyocyte and neuronal apoptosis (By similarity). In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex (PubMed:20849813). In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity (PubMed:10386996, PubMed:11060309). Also essential for hypoxic regulation of neutrophilic inflammation (By similarity). Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway (By similarity). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.32;2.3.2.24;2.3.2.23;1.14.11.29;3.4.25.1;1.14.11.-", "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0031543 peptidyl-proline dioxygenase activity;GO:0031545 peptidyl-proline 4-dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0071456 cellular response to hypoxia;GO:1990830 cellular response to leukemia inhibitory factor;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJ16-1", "uniprot_id": "5HT3B_RAT", "mass": 50336.0, "length": 437, "protein_name": "5-hydroxytryptamine receptor 3B", "gene_name": "Htr3b", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 3B precursor", "refseq_ac": "NP_071525", "gene_names_uniprotkb": "Htr3b", "gene_names_refseq": "Htr3b", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 3B; 5-HT3-B; 5-HT3B; Serotonin receptor 3B", "protein_names_refseq": "5-HT-3B; 5-HT3-B; 5-HT3B; 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic; 5-hydroxytryptamine receptor 3B precursor; serotonin receptor 3B; serotonin-gated ion channel subunit", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:58963); (R-RNO-112314)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10854267;12151552;21849148", "class_list": "", "function": "Chinese herbal medicines for regulating liver qi may treat anger emotion in rats by improving the hypothalamic 5-HT3BR protein and gene expression levels., [RefSeq, PubMed]; Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERJ5", "ec_number_list": "2.7.11.1;1.8.-.-", "go_molecular_function": "GO:0022850 serotonin-gated monoatomic cation channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0071363 cellular response to growth factor stimulus;GO:0007210 serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JJ16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Z62-1", "uniprot_id": "FBX32_RAT", "mass": 40926.0, "length": 350, "protein_name": "F-box only protein 32", "gene_name": "Fbxo32", "organism": "Rat", "refseq_name": "F-box only protein 32", "refseq_ac": "NP_598205", "gene_names_uniprotkb": "Fbxo32", "gene_names_refseq": "Atrogin1; Fbxo32; MAFbx", "protein_names_uniprotkb": "F-box only protein 32; Atrogin-1; MAFbx; Muscle atrophy F-box protein", "protein_names_refseq": "F-box only protein 32; atrogin-1; atrophy gene 1; component of SCF E3 ubiquitin ligase; involved in ubiquitin-mediated protein degradation during skeletal muscle atrophy; muscle atrophy F-box protein", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); primary pulmonary hypertension (Disease Ontology:DOID:14557); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:171043); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11679633;12782319;15284206;15726428;16714087;28000044;28246104;30312703;31311969;32646070", "class_list": "", "function": "Alternate name for this locus: MAFbx. Alias: MAFbx., [RefSeq, PubMed]; Atrogin-1 is involved in the early stages of skeletal muscle regeneration in rats, independently of calcineurin., [RefSeq, PubMed]; Atrogin-1/MAFbx mRNA expression is regulated by histone deacetylase 1 in rat soleus muscle under hindlimb unloading. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that FOXO3a plays a role in muscle atrophy through regulation of expression of MuRF1 and atrogin-1 in skeletal muscle in Cushing's syndrome. (FOXO3a = forkhead box protein O3a; MuRF1 = muscle-specific RING finger protein 1), [RefSeq, PubMed]; Differences in the Role of HDACs 4 and 5 in the Modulation of Processes Regulating MAFbx and MuRF1 Expression during Muscle Unloading. Publication Status: Online-Only, [RefSeq, PubMed]; Exercise down-regulated the mRNA levels of murf1 and atrogin-1, decreased reactive oxygen species level, increased antioxidant capacity, regulated the expression of insulin-like growth factor 1 (IGF1), mechano growth factor (MGF), Neuregulin1 (NRG1) and Myostatin (MSTN), and activated Akt and Erk1/2 signalings in soleus muscle., [RefSeq, PubMed]; FBXO25 is a novel F-box protein analogous to atrogin-1, which is not involved in muscle atrophy., [RefSeq, PubMed]; IGF-I inhibits atrogin-1/MAFbx expression, [RefSeq, PubMed]; Independent of the metabolic condition, after muscle contraction, both TRIM63 and FBXO32 proteins correlated significantly with miR-1-3p, miR-29a/b-3p, and miR-133a/b-3p., [RefSeq, PubMed]; MafBx and Murf mRNA are up-regulated in response to LPS and might play a role in the muscle proteolysis observed, [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. Negatively regulates macrophage efferocytosis by promoting the ubiquitination of the transcription factor KLF4, suppressing the receptor tyrosine kinase MERTK transcription (By similarity). Regulates LPS-induced apoptosis and mitochondrial dysfunction through ANXA1 ubiquitination and degradation (By similarity). Mediates cyclin D1 protein stabilization via 'Lys-27'-linked ubiquitination (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0071549 cellular response to dexamethasone stimulus;GO:0016567 protein ubiquitination;GO:0014894 response to denervation involved in regulation of muscle adaptation;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0010666 positive regulation of cardiac muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91Z62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62994-1", "uniprot_id": "FUT4_RAT", "mass": 48779.0, "length": 433, "protein_name": "Alpha-(1,3)-fucosyltransferase 4", "gene_name": "Fut4", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fut4; Rfuc-t", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-(1,3)-fucosyltransferase 4; 2.4.1.152; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; Fuc-TIV; FucT-IV; Fucosyltransferase 4; Fucosyltransferase IV; Galactoside 3-L-fucosyltransferase", "protein_names_refseq": "", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:60670); (R-RNO-9037629)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9111142", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.152", "go_molecular_function": "GO:0046920 alpha-(1->3)-fucosyltransferase activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0032580 Golgi cisterna membrane;GO:0071944 cell periphery;GO:0005802 trans-Golgi network", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006688 glycosphingolipid biosynthetic process;GO:0006954 inflammatory response;GO:0006493 protein O-linked glycosylation;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 1336, "hit_score": 0.2, "record_id": "Q62994-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69FH1-1", "uniprot_id": "CLC4D_RAT", "mass": 25312.0, "length": 218, "protein_name": "C-type lectin domain family 4 member D", "gene_name": "Clec4d", "organism": "Rat", "refseq_name": "C-type lectin domain family 4 member D", "refseq_ac": "NP_001003707", "gene_names_uniprotkb": "Clec4d; Clecsf8; Mcl", "gene_names_refseq": "Clec4d; Clecsf8; Mcl", "protein_names_uniprotkb": "C-type lectin domain family 4 member D; C-type lectin superfamily member 8", "protein_names_refseq": "C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 8; C-type lectin domain family 4 member D; C-type lectin superfamily member 8; macrophage C-type lectin", "tax_id": 10116, "disease": "", "pathway": " (rno:362432); (R-RNO-5621480); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15368084;23921530;31725411", "class_list": "", "function": "C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation., [RefSeq, PubMed]; Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (By similarity). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (PubMed:23921530). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (By similarity)., [UniProtKB, PubMed, UniProtKB]; The results presented in this paper suggest that the Mincle/MCL/FcepsilonRI-gamma complex is the functionally optimal form for these C-type lectin receptors on the surface of myeloid cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2TUL6", "ec_number_list": "", "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002292 T cell differentiation involved in immune response;GO:0038094 Fc-gamma receptor signaling pathway;GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q69FH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66HF8-1", "uniprot_id": "AL1B1_RAT", "mass": 57625.0, "length": 519, "protein_name": "Aldehyde dehydrogenase family 1 member B1, mitochondrial", "gene_name": "Aldh1b1", "organism": "Rat", "refseq_name": "aldehyde dehydrogenase X, mitochondrial precursor", "refseq_ac": "NP_001011975", "gene_names_uniprotkb": "Aldh1b1", "gene_names_refseq": "Aldh1b1", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 1 member B1, mitochondrial; 1.2.1.28; 1.2.1.36; 1.2.1.3; 1.7.1.-; Nitroglycerin reductase ALDH1B1", "protein_names_refseq": "aldehyde dehydrogenase 1B1; aldehyde dehydrogenase X, mitochondrial precursor; aldehyde dehydrogenase X, mitochondrial; aldehyde dehydrogenase family 1 member B1", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:298079); (R-RNO-71384); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Broad specificity, mitochondrial aldehyde dehydrogenase that could play a role in the detoxification of alcohol-derived acetaldehyde and other aldehydes. Shows an absolute preference for NAD(+) as no activity is detected with NADP(+). Has a high affinity and catalytic efficiency toward aliphatic medium-chain saturated aldehydes relative to short-chain and aromatic aldehydes in vitro. Also capable of metabolizing products of lipid peroxidation, namely 4-hydroxynon-2-enal(4-HNE) and malonaldehyde (MDA) but with lower catalytic efficiency. In vitro, it can also display a nitroglycerin reductase activity. Has also an esterase activity in vitro, but this may be not physiologically relevant in vivo., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.5;1.3.8.5;6.2.1.4;4.98.1.1;5.6.2.3;2.8.3.5;2.3.1.-;2.3.1.41;3.4.21.92;3.5.3.1;3.1.2.2;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;3.1.2.-;1.1.1.37;6.4.1.3;7.1.2.2;1.4.1.3;1.2.1.5;1.2.1.3;2.3.1.37;4.2.1.2;2.3.1.9;2.3.3.10;5.3.3.8;1.1.1.30;1.2.1.94;3.6.4.10;1.2.4.1;1.2.1.36;1.2.1.19;1.2.1.28;1.1.1.42;5.6.1.7;1.3.8.1;2.7.1.23;1.1.1.-;1.1.1.105;1.2.1.7;1.2.1.48;1.2.4.2;5.3.3.21;2.7.11.2;2.7.11.-;1.2.1.31;1.2.1.8;7.1.1.2;1.7.1.-;1.8.1.4;2.3.3.1;3.4.21.53;1.1.1.41;4.2.1.3;1.2.1.47;1.2.1.46", "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006068 ethanol catabolic process;GO:0006081 aldehyde metabolic process;GO:0048732 gland development;GO:0110095 cellular detoxification of aldehyde", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63180-1", "uniprot_id": "ADAM7_RAT", "mass": 89362.0, "length": 789, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 7", "gene_name": "Adam7", "organism": "Rat", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 7 precursor", "refseq_ac": "NP_064697", "gene_names_uniprotkb": "Adam7; Eapi", "gene_names_refseq": "ADAM 7; ADAM; Adam7; EAP I; EAPI; EAP", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 7; ADAM 7; EAP I; Epididymal apical protein I", "protein_names_refseq": "a disintegrin and metallopeptidase domain 7; a disintegrin and metalloprotease domain (ADAM) 7; a disintegrin and metalloprotease domain 7; disintegrin and metalloproteinase domain-containing protein 7 precursor; disintegrin and metalloproteinase domain-containing protein 7; epididymal apical protein I", "tax_id": 10116, "disease": "", "pathway": " (rno:29641)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1417724;15883027", "class_list": "", "function": "ADAM7, but not ADAM28, is transferred from the epididymis to the sperm surface and redistributed in the sperm head during acrosome reaction, [RefSeq, PubMed]; Required for normal male fertility via maintenance of epithelial cell morphology in the caput epididymis and subsequently correct epididymis lumen structure required for sperm development (By similarity). Plays a role in sperm motility, flagella morphology and tyrosine phosphorylation during sperm capacitance (By similarity). Plays a role in normal expression levels of HSPA5, ITM2B and ADAM2 in sperm both prior to and post-capacitation (By similarity). This is a non catalytic metalloprotease-like protein (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045177 apical part of cell", "go_biological_process": "GO:0006508 proteolysis;GO:0003382 epithelial cell morphogenesis;GO:1902093 positive regulation of flagellated sperm motility;GO:1905867 epididymis development;GO:1902492 positive regulation of sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ES45-1", "uniprot_id": "DUOX2_RAT", "mass": 171558.0, "length": 1517, "protein_name": "Dual oxidase 2", "gene_name": "Duox2", "organism": "Rat", "refseq_name": "dual oxidase 2 precursor", "refseq_ac": "NP_077055", "gene_names_uniprotkb": "Duox2; Lnox2; Thox2", "gene_names_refseq": "Duox2; Thox2", "protein_names_uniprotkb": "Dual oxidase 2; 1.-.-.-; 1.11.1.-; 1.6.3.1; Large NOX 2; Long NOX 2; NADH/NADPH thyroid oxidase THOX2; Thyroid oxidase 2", "protein_names_refseq": "NADH/NADPH thyroid oxidase THOX2; dual oxidase 2 precursor; large NOX 2; long NOX 2; thyroid oxidase 2", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); primary bacterial infectious disease (Disease Ontology:DOID:0050338); thyroid dyshormonogenesis 6 (Disease Ontology:DOID:0112189); hypothyroidism (Disease Ontology:DOID:1459); cholera (Disease Ontology:DOID:1498); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (rno:79107); (R-RNO-209968)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11032719;12538618;12824283", "class_list": "", "function": "Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormone synthesis. Also required for lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. Synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation. May have its own peroxidase activity through its N-terminal peroxidase-like domain., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q811Y4", "ec_number_list": "1.6.3.1;1.14.13.225;1.-.-.-;1.11.1.8;1.6.99.1;1.11.1.-;1.14.13.8", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0004601 peroxidase activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0030878 thyroid gland development;GO:0042335 cuticle development;GO:0048855 adenohypophysis morphogenesis;GO:0006952 defense response;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ES45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YN4-1", "uniprot_id": "CORIN_RAT", "mass": 122757.0, "length": 1111, "protein_name": "Atrial natriuretic peptide-converting enzyme", "gene_name": "Corin", "organism": "Rat", "refseq_name": "atrial natriuretic peptide-converting enzyme", "refseq_ac": "NP_872279", "gene_names_uniprotkb": "Corin", "gene_names_refseq": "Corin", "protein_names_uniprotkb": "Atrial natriuretic peptide-converting enzyme; 3.4.21.-; Corin; Pro-ANP-converting enzyme", "protein_names_refseq": "atrial natriuretic peptide-converting enzyme; pro-ANP-converting enzyme", "tax_id": 10116, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:289596); (R-RNO-5578768)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15155264;15191894;17660514;20613715;26446774;28106289;28985241", "class_list": "", "function": "Corin contributes to the progression of diabetic ED and the underlying mechanism is associated with the down-regulation of ANP /NO/cGMP signal pathway., [RefSeq, PubMed]; Corin gene is upregulated in hypertrophic cardiomyocytes and failing myocardium and may contribute to elevation of ANP in the setting of cardiac hypertrophy and heart failure., [RefSeq, PubMed]; Corin mRNA and protein are downregulated in diabetic cardiomyopathy (DCM). Corin plays an important role in cardioprotection by activating pro-atrial natriuretic peptide pathway in DCM. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of atrial corin mRNA expression may be a novel mechanism for the blunted ANP release in heart failure., [RefSeq, PubMed]; Enhanced serum corin level in humans and rodents is positively correlated with high salt diet-induced systolic blood pressure and 24-hour urinary Na+ and albumin excretion, which suggests that corin is involved in the salt-water balance in response to HS intake., [RefSeq, PubMed]; Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing (PubMed:17660514). Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation (By similarity). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (By similarity). Also acts as a regulator of sodium reabsorption in kidney (PubMed:20613715). May also process pro-NPPB the B-type natriuretic peptide (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D3ZN44;F1LS60", "ec_number_list": "3.4.21.-", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide;GO:0016486 peptide hormone processing;GO:0008217 regulation of blood pressure;GO:0007565 female pregnancy;GO:0035813 regulation of renal sodium excretion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80YN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P7B9-1", "uniprot_id": "SCD2_RAT", "mass": 41013.0, "length": 358, "protein_name": "Stearoyl-CoA desaturase 2", "gene_name": "Scd2", "organism": "Rat", "refseq_name": "stearoyl-CoA desaturase 2", "refseq_ac": "NP_114029", "gene_names_uniprotkb": "Scd2", "gene_names_refseq": "Scd2; Scd", "protein_names_uniprotkb": "Stearoyl-CoA desaturase 2; 1.14.19.1; Acyl-CoA desaturase 2; Delta(9)-desaturase 2; Delta-9 desaturase 2; Fatty acid desaturase 2", "protein_names_refseq": "acyl-CoA desaturase 2; delta(9)-desaturase 2; fatty acid desaturase 2; stearoyl-CoA desaturase (delta-9-desaturase); stearoyl-CoA desaturase 2", "tax_id": 10116, "disease": "restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": " (rno:83792)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12606372;1982442;20228221;21266672;7800118", "class_list": "", "function": "Overt type 2 diabetes is associated with diminished islet expression of SCD and Elovl6, and this can disrupt desaturation of saturated FAs to MUFAs, rendering beta-cells more susceptible to saturated FA-induced ER stress and apoptosis., [RefSeq, PubMed]; Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:20228221). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:20228221). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides, especially during embryonic development and in neonates. Important for normal permeability barrier function of the skin in neonates., [UniProtKB, UniProtKB, PubMed]; Testicular distribution of Delta5- and Delta6-desaturase and stearoyl-CoA desaturase 1 and 2 shows that all four desaturases seem to be localized in the Sertoli cells, with far lower expression in germ cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64066;Q9JMC9", "ec_number_list": "1.14.19.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0032896 palmitoyl-CoA 9-desaturase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0042552 myelination;GO:0006636 unsaturated fatty acid biosynthetic process;GO:1903966 monounsaturated fatty acid biosynthetic process;GO:0070542 response to fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P7B9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZH8-1", "uniprot_id": "AAAD_RAT", "mass": 45693.0, "length": 398, "protein_name": "Arylacetamide deacetylase", "gene_name": "Aadac", "organism": "Rat", "refseq_name": "arylacetamide deacetylase", "refseq_ac": "NP_065413", "gene_names_uniprotkb": "Aadac; Aada", "gene_names_refseq": "Aadac; Aada", "protein_names_uniprotkb": "Arylacetamide deacetylase; 3.1.1.3", "protein_names_refseq": "arylacetamide deacetylase (esterase); arylacetamide deacetylase", "tax_id": 10116, "disease": "", "pathway": " (rno:57300); (R-RNO-211945)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11481320;22207054", "class_list": "", "function": "Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity). Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.3;2.3.1.51;3.1.1.4;3.1.1.23;3.1.1.79;3.1.1.6;3.1.1.5;3.1.1.32;3.1.1.13;3.1.1.-;3.1.1.116;3.1.1.26;3.1.1.34", "go_molecular_function": "GO:0017171 serine hydrolase activity;GO:0004806 triacylglycerol lipase activity;GO:0019213 deacetylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0010898 positive regulation of triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RK23-1", "uniprot_id": "ABHD1_RAT", "mass": 45557.0, "length": 412, "protein_name": "Protein ABHD1", "gene_name": "Abhd1", "organism": "Rat", "refseq_name": "protein ABHD1", "refseq_ac": "NP_001008520", "gene_names_uniprotkb": "Abhd1", "gene_names_refseq": "Abhd1", "protein_names_uniprotkb": "Protein ABHD1; 3.1.1.-; Abhydrolase domain-containing protein 1; Alpha/beta hydrolase domain-containing protein 1", "protein_names_refseq": "abhydrolase domain-containing protein 1; alpha/beta hydrolase domain-containing protein 1; protein ABHD1", "tax_id": 10116, "disease": "", "pathway": " (rno:313917)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0008126 acetylesterase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0051793 medium-chain fatty acid catabolic process;GO:0051792 medium-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RK23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RKJ0-1", "uniprot_id": "F110C_RAT", "mass": 35578.0, "length": 326, "protein_name": "Protein FAM110C", "gene_name": "Fam110c", "organism": "Rat", "refseq_name": "protein FAM110C", "refseq_ac": "NP_001020222", "gene_names_uniprotkb": "Fam110c", "gene_names_refseq": "Fam110c", "protein_names_uniprotkb": "Protein FAM110C", "protein_names_refseq": "protein FAM110C", "tax_id": 10116, "disease": "", "pathway": " (rno:500638)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22460667", "class_list": "", "function": "May control granulosa cell differentiation into luteal cells by arresting cell cycle progression Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005938 cell cortex", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0060491 regulation of cell projection assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RKJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U1Y4-1", "uniprot_id": "AKCL2_RAT", "mass": 34500.0, "length": 301, "protein_name": "1,5-anhydro-D-fructose reductase", "gene_name": "Akr1e2", "organism": "Rat", "refseq_name": "1,5-anhydro-D-fructose reductase", "refseq_ac": "NP_001008343", "gene_names_uniprotkb": "Akr1e2; Akr1cl2", "gene_names_refseq": "Akr1cl2; Akr1e1; Akr1e2", "protein_names_uniprotkb": "1,5-anhydro-D-fructose reductase; 1.1.1.263; AF reductase; Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member E2", "protein_names_refseq": "1,5-anhydro-D-fructose reductase; AF reductase; aldo-keto reductase family 1 member C-like protein 2; aldo-keto reductase family 1, member C-like 2; aldo-keto reductase family 1, member E1", "tax_id": 10116, "disease": "", "pathway": " (rno:307091); (R-RNO-70221)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.263", "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0016491 oxidoreductase activity;GO:0050571 1,5-anhydro-D-fructose reductase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U1Y4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U1Y9-1", "uniprot_id": "F216A_RAT", "mass": 29483.0, "length": 261, "protein_name": "Protein FAM216A", "gene_name": "Fam216a", "organism": "Rat", "refseq_name": "protein FAM216A", "refseq_ac": "NP_001008291", "gene_names_uniprotkb": "Fam216a", "gene_names_refseq": "Fam216a; RGD1310861", "protein_names_uniprotkb": "Protein FAM216A", "protein_names_refseq": "protein FAM216A; uncharacterized protein C12orf24 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:288667)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U1Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U201-1", "uniprot_id": "AMN1_RAT", "mass": 28466.0, "length": 258, "protein_name": "Protein AMN1 homolog", "gene_name": "Amn1", "organism": "Rat", "refseq_name": "protein AMN1 homolog", "refseq_ac": "NP_001008334", "gene_names_uniprotkb": "Amn1", "gene_names_refseq": "Amn1; RGD1308119", "protein_names_uniprotkb": "Protein AMN1 homolog", "protein_names_refseq": "protein AMN1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:302032)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex;GO:0031528 microvillus membrane", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U201-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U216-1", "uniprot_id": "DX39A_RAT", "mass": 49109.0, "length": 427, "protein_name": "ATP-dependent RNA helicase DDX39A", "gene_name": "Ddx39a", "organism": "Rat", "refseq_name": "ATP-dependent RNA helicase DDX39A", "refseq_ac": "NP_446015", "gene_names_uniprotkb": "Ddx39a; Ddx39; Ddxl", "gene_names_refseq": "Ddx39a; Ddx39; Ddxl", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX39A; 3.6.4.13; DEAD box protein 39; Nuclear RNA helicase, DECD variant of DEAD box family", "protein_names_refseq": "ATP-dependent RNA helicase DDX39A; ATP-dependent RNA helicase DDX39; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39; DEAD box protein 39; DEAD-box helicase 39A; nuclear RNA helicase, DECD variant of DEAD box family", "tax_id": 10116, "disease": "", "pathway": " (rno:89827); (R-RNO-159236)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21168220", "class_list": "", "function": "Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing. Regulates nuclear mRNA export to the cytoplasm through association with ECD. Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX. Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression. Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA., [UniProtKB, UniProtKB]; Overexpression of SOCS3 was found to reduce the level of calcium ionophore-induced phosphorylation of ERK1/2 and c-Jun transcription factor, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70498", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.1.4.-;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0046832 negative regulation of RNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0000398 mRNA splicing, via spliceosome;GO:0045824 negative regulation of innate immune response;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U216-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2Q3-1", "uniprot_id": "BKGD_RAT", "mass": 34993.0, "length": 315, "protein_name": "Beta-keto L-gulonate decarboxylase", "gene_name": "Bkgd", "organism": "Rat", "refseq_name": "beta-keto L-gulonate decarboxylase", "refseq_ac": "NP_001014228", "gene_names_uniprotkb": "Bkgd; C8h11orf54; RGD1309534", "gene_names_refseq": "Bkgd; C8h11orf54; RGD1309534", "protein_names_uniprotkb": "Beta-keto L-gulonate decarboxylase; 4.1.1.34; BKGD", "protein_names_refseq": "beta-keto L-gulonate decarboxylase; ester hydrolase C11orf54 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:363016)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the decarboxylation of 3-dehydro-L-gulonate to produce L-xylulose, used in the pentose pathway (By similarity). Exhibits ester hydrolase activity on p-nitrophenyl acetate, in vitro (By similarity). Regulates DNA damage and repair by regulating HIF1A degradation via chaperone-mediated autophagy (CMA) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.34", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016788 hydrolase activity, acting on ester bonds;GO:0047842 dehydro-L-gulonate decarboxylase activity;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2Q7-1", "uniprot_id": "ERF1_RAT", "mass": 49031.0, "length": 437, "protein_name": "Eukaryotic peptide chain release factor subunit 1", "gene_name": "Etf1", "organism": "Rat", "refseq_name": "eukaryotic peptide chain release factor subunit 1", "refseq_ac": "NP_001008345", "gene_names_uniprotkb": "Etf1", "gene_names_refseq": "Etf1", "protein_names_uniprotkb": "Eukaryotic peptide chain release factor subunit 1; Eukaryotic release factor 1; eRF1", "protein_names_refseq": "eRF1; eukaryotic peptide chain release factor subunit 1; eukaryotic release factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:307503); (R-RNO-9629569); (R-RNO-975956); (R-RNO-975957)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons. The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA. Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site, followed by hydrolysis of peptidyl-tRNA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004045 peptidyl-tRNA hydrolase activity;GO:1990825 sequence-specific mRNA binding;GO:0008079 translation termination factor activity;GO:0003747 translation release factor activity;GO:0016149 translation release factor activity, codon specific", "go_cellular_component": "GO:0018444 translation release factor complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0002184 cytoplasmic translational termination;GO:0006415 translational termination;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006479 protein methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2Q7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2R1-1", "uniprot_id": "DLP1_RAT", "mass": 44295.0, "length": 401, "protein_name": "All trans-polyprenyl-diphosphate synthase PDSS2", "gene_name": "Pdss2", "organism": "Rat", "refseq_name": "all trans-polyprenyl-diphosphate synthase PDSS2", "refseq_ac": "NP_001014271", "gene_names_uniprotkb": "Pdss2; Dlp1", "gene_names_refseq": "Pdss2", "protein_names_uniprotkb": "All trans-polyprenyl-diphosphate synthase PDSS2; 2.5.1.91; All-trans-decaprenyl-diphosphate synthase subunit 2; Decaprenyl-diphosphate synthase subunit 2; Solanesyl-diphosphate synthase subunit 2", "protein_names_refseq": "all trans-polyprenyl-diphosphate synthase PDSS2; all-trans-decaprenyl-diphosphate synthase subunit 2; decaprenyl pyrophosphate synthase subunit 2; decaprenyl pyrophosphate synthetase subunit 2; prenyl (decaprenyl) diphosphate synthase, subunit 2; prenyl (solanesyl) diphosphate synthase, subunit 2; solanesyl-diphosphate synthase subunit 2", "tax_id": 10116, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 3 (Disease Ontology:DOID:0070240); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:365592); (R-RNO-2142789)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone. Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9) and ubiquinone-10 (Q10) respectively. The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (By similarity). May play a role during cerebellar development (By similarity). May regulate mitochondrial respiratory chain function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.91", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004659 prenyltransferase activity;GO:0097269 all-trans-decaprenyl-diphosphate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0032478 heterotetrameric polyprenyl diphosphate synthase complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0050878 regulation of body fluid levels;GO:0021549 cerebellum development;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2R1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2U6-1", "uniprot_id": "CDIP1_RAT", "mass": 21858.0, "length": 208, "protein_name": "Cell death-inducing p53-target protein 1", "gene_name": "Cdip1", "organism": "Rat", "refseq_name": "cell death-inducing p53-target protein 1", "refseq_ac": "NP_001008361", "gene_names_uniprotkb": "Cdip1", "gene_names_refseq": "Cdip1; RGD1310686", "protein_names_uniprotkb": "Cell death-inducing p53-target protein 1; LITAF-like protein", "protein_names_refseq": "LITAF-like protein; cell death-inducing p53-target protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:360480)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an important p53/TP53-apoptotic effector. Regulates TNF-mediated apoptosis in a p53/TP53-dependent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0098574 cytoplasmic side of lysosomal membrane;GO:0098560 cytoplasmic side of late endosome membrane", "go_biological_process": "GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2X4-1", "uniprot_id": "DPEP3_RAT", "mass": 53370.0, "length": 488, "protein_name": "Dipeptidase 3", "gene_name": "Dpep3", "organism": "Rat", "refseq_name": "dipeptidase 3 precursor", "refseq_ac": "NP_001008384", "gene_names_uniprotkb": "Dpep3", "gene_names_refseq": "Dpep3", "protein_names_uniprotkb": "Dipeptidase 3", "protein_names_refseq": "dipeptidase 3 precursor; putative membrane-bound dipeptidase 3", "tax_id": 10116, "disease": "", "pathway": " (rno:364994)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (By similarity). The absence of activity may be due to the inability of serine (instead of aspartate found in DPEP1/2) at position 356 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008233 peptidase activity;GO:0016805 dipeptidase activity;GO:0070573 metallodipeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0001669 acrosomal vesicle;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U2Z2-1", "uniprot_id": "AJUBA_RAT", "mass": 58081.0, "length": 548, "protein_name": "LIM domain-containing protein ajuba", "gene_name": "Ajuba", "organism": "Rat", "refseq_name": "LIM domain-containing protein ajuba", "refseq_ac": "NP_445955", "gene_names_uniprotkb": "Ajuba; Jub", "gene_names_refseq": "Ajuba; Jub", "protein_names_uniprotkb": "LIM domain-containing protein ajuba", "protein_names_refseq": "LIM domain-containing protein ajuba; ajuba homolog; jub, ajuba homolog; protein ajuba", "tax_id": 10116, "disease": "", "pathway": " (rno:85265); (R-RNO-1234176); (R-RNO-2565942); (R-RNO-9841922)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11860269", "class_list": "", "function": "Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1 (By similarity)., [UniProtKB]; We propose that Ajuba is a scaffolding protein allowing GLT-1 to regulate intracellular signaling or interact with the cytoskeleton., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99ND4", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0003714 transcription corepressor activity;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0046474 glycerophospholipid biosynthetic process;GO:0001666 response to hypoxia;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2Z2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U305-1", "uniprot_id": "ERD22_RAT", "mass": 24454.0, "length": 212, "protein_name": "ER lumen protein-retaining receptor 2", "gene_name": "Kdelr2", "organism": "Rat", "refseq_name": "ER lumen protein-retaining receptor 2", "refseq_ac": "NP_001013140", "gene_names_uniprotkb": "Kdelr2", "gene_names_refseq": "Kdelr2", "protein_names_uniprotkb": "ER lumen protein-retaining receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2", "protein_names_refseq": "ER lumen protein-retaining receptor 2; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; KDEL receptor 2", "tax_id": 10116, "disease": "osteogenesis imperfecta type 21 (Disease Ontology:DOID:0112201)", "pathway": " (rno:304290); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005046 KDEL sequence binding;GO:0046923 ER retention sequence binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen;GO:0035437 maintenance of protein localization in endoplasmic reticulum;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U305-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U777-1", "uniprot_id": "APR_RAT", "mass": 11901.0, "length": 105, "protein_name": "Phorbol-12-myristate-13-acetate-induced protein 1", "gene_name": "Pmaip1", "organism": "Rat", "refseq_name": "phorbol-12-myristate-13-acetate-induced protein 1", "refseq_ac": "NP_001008386", "gene_names_uniprotkb": "Pmaip1; Noxa", "gene_names_refseq": "Noxa; Pmaip1", "protein_names_uniprotkb": "Phorbol-12-myristate-13-acetate-induced protein 1; Protein Noxa", "protein_names_refseq": "phorbol-12-myristate-13-acetate-induced protein 1; protein Noxa", "tax_id": 10116, "disease": "", "pathway": " (rno:492821); (R-RNO-111448); (R-RNO-111453)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21660051;22785021;28131915;29393594;37580530;38691334", "class_list": "", "function": "Chromatin remodeling factor, INO80, inhibits PMAIP1 in renal tubular cells via exchange of histone variant H2A.Z. for H2A. Publication Status: Online-Only, [RefSeq, PubMed]; Intracellular zinc release-activated ERK-dependent GSK-3beta-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury., [RefSeq, PubMed]; PMAIP1 regulates autophagy in osteoblasts via the AMPK/mTOR pathway in osteoporosis., [RefSeq, PubMed]; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity)., [UniProtKB]; The expression levels of BimEL and Noxa were elevated 3 h after reperfusion., [RefSeq, PubMed]; These findings reveal a novel regulatory mechanism of ROCK1/p53/NOXA signaling in modulating cardiomyocyte apoptosis in vitro and maternal diabetes-induced congenital heart defects in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0097136 Bcl-2 family protein complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051607 defense response to virus;GO:0006915 apoptotic process;GO:0071456 cellular response to hypoxia;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5U777-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5UEM7-1", "uniprot_id": "CR3L4_RAT", "mass": 40281.0, "length": 367, "protein_name": "Cyclic AMP-responsive element-binding protein 3-like protein 4", "gene_name": "Creb3l4", "organism": "Rat", "refseq_name": "cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1", "refseq_ac": "NP_001007094", "gene_names_uniprotkb": "Creb3l4; Aibzip", "gene_names_refseq": "AIbZIP; Creb3l4", "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 3-like protein 4; AIbZIP; Androgen-induced basic leucine zipper protein; cAMP-responsive element-binding protein 3-like protein 4", "protein_names_refseq": "androgen-induced bZIP protein; androgen-induced basic leucine zipper protein; cAMP-responsive element-binding protein 3-like protein 4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1; cyclic AMP-responsive element-binding protein 3-like protein 4", "tax_id": 10116, "disease": "prostate adenocarcinoma (Disease Ontology:DOID:2526); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:310616)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Increases the binding of CREM isoform Delta with CRE. The CREM isoform Delta-CREB3L4 heterodimer functions through CRE but not through UPRE and may recruit HIRA to CRE to regulate histone exchange (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5UEM6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5UEM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XI29-1", "uniprot_id": "CPSF7_RAT", "mass": 51073.0, "length": 462, "protein_name": "Cleavage and polyadenylation specificity factor subunit 7", "gene_name": "Cpsf7", "organism": "Rat", "refseq_name": "cleavage and polyadenylation specificity factor subunit 7 isoform 2", "refseq_ac": "NP_001014267", "gene_names_uniprotkb": "Cpsf7", "gene_names_refseq": "Cpsf7; RGD1305441", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 7", "protein_names_refseq": "cleavage and polyadenylation specific factor 7, 59kDa; cleavage and polyadenylation specificity factor subunit 7 isoform 2; cleavage and polyadenylation specificity factor subunit 7", "tax_id": 10116, "disease": "", "pathway": " (rno:365407); (R-RNO-73856); (R-RNO-77595); (R-RNO-9013422); (R-RNO-9770562)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0051262 protein tetramerization;GO:0051290 protein heterotetramerization;GO:0031124 mRNA 3'-end processing;GO:0110104 mRNA alternative polyadenylation;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XI46-1", "uniprot_id": "PAAT_RAT", "mass": 48820.0, "length": 444, "protein_name": "ATPase PAAT", "gene_name": "C1h10orf88; Paat", "organism": "Rat", "refseq_name": "ATPase PAAT", "refseq_ac": "NP_001014047", "gene_names_uniprotkb": "C1h10orf88; Paat; RGD1305014", "gene_names_refseq": "C1h10orf88; PAAT; RGD1305014", "protein_names_uniprotkb": "ATPase PAAT; 3.6.1.-; PAAT; Protein associated with ABC transporters", "protein_names_refseq": "ATPase PAAT; protein associated with ABC transporters; uncharacterized protein C10orf88 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:309029)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10. Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.1.4.-;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XI95-1", "uniprot_id": "ADH6_RAT", "mass": 39726.0, "length": 376, "protein_name": "Alcohol dehydrogenase 6", "gene_name": "Adh6", "organism": "Rat", "refseq_name": "alcohol dehydrogenase 6", "refseq_ac": "NP_001012084", "gene_names_uniprotkb": "Adh6", "gene_names_refseq": "Adh6", "protein_names_uniprotkb": "Alcohol dehydrogenase 6; 1.1.1.1", "protein_names_refseq": "alcohol dehydrogenase 6; class V alcohol dehydrogenase", "tax_id": 10116, "disease": "", "pathway": " (rno:310903); (R-RNO-71384)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Alcohol dehydrogenase (By similarity). Catalyzes the NAD-dependent oxidation of primary alcohols to the corresponding aldehydes (By similarity). Oxidizes secondary alcohols to the corresponding ketones (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.1;1.1.1.-;1.1.1.284;1.1.1.105;1.1.1.66", "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0008270 zinc ion binding;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0042573 retinoic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XI97-1", "uniprot_id": "AASD1_RAT", "mass": 45093.0, "length": 412, "protein_name": "Alanyl-tRNA editing protein Aarsd1", "gene_name": "Aarsd1", "organism": "Rat", "refseq_name": "alanyl-tRNA editing protein Aarsd1", "refseq_ac": "NP_001029281", "gene_names_uniprotkb": "Aarsd1", "gene_names_refseq": "Aarsd1", "protein_names_uniprotkb": "Alanyl-tRNA editing protein Aarsd1; Alanyl-tRNA synthetase domain-containing protein 1", "protein_names_refseq": "alanyl-tRNA editing protein Aarsd1; alanyl-tRNA synthetase domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:619440)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0002196 Ser-tRNA(Ala) deacylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006419 alanyl-tRNA aminoacylation;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XI97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIA0-1", "uniprot_id": "DZI1L_RAT", "mass": 88025.0, "length": 776, "protein_name": "Cilium assembly protein DZIP1L", "gene_name": "Dzip1l", "organism": "Rat", "refseq_name": "cilium assembly protein DZIP1L", "refseq_ac": "NP_001014117", "gene_names_uniprotkb": "Dzip1l", "gene_names_refseq": "Dzip1l; RGD1311430", "protein_names_uniprotkb": "Cilium assembly protein DZIP1L; DAZ-interacting zinc finger protein 1-like", "protein_names_refseq": "DAZ interacting protein 1-like; DAZ-interacting protein 1-like protein; cilium assembly protein DZIP1L; zinc finger protein DZIP1L", "tax_id": 10116, "disease": "polycystic kidney disease 5 (Disease Ontology:DOID:0080273); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861)", "pathway": " (rno:315952)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005814 centriole;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:0021532 neural tube patterning;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XID1-1", "uniprot_id": "CPIN1_RAT", "mass": 33042.0, "length": 309, "protein_name": "Anamorsin", "gene_name": "Ciapin1", "organism": "Rat", "refseq_name": "anamorsin", "refseq_ac": "NP_001007690", "gene_names_uniprotkb": "Ciapin1; CIAPIN1", "gene_names_refseq": "Ciapin1", "protein_names_uniprotkb": "Anamorsin; Cytokine-induced apoptosis inhibitor 1; Fe-S cluster assembly protein DRE2 homolog", "protein_names_refseq": "anamorsin; fe-S cluster assembly protein DRE2 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:307649)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;29671338;31432171;33538533", "class_list": "", "function": "Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]; Inhibition of miR-322-5p Protects Cardiac Myoblast Cells Against Hypoxia-Induced Apoptosis and Injury Through Regulating CIAPIN1., [RefSeq, PubMed]; The knockdown of CIAPIN1 with small interfering RNAs (siRNAs) efficiently abolished the protective effects of miR-182-5p inhibitor on HICA, demonstrating that miR-182-5p plays a pro-apoptotic role in cardiomyocytes under hypoxic conditions by downregulating CIAPIN1., [RefSeq, PubMed]; The present study illustrates that downregulation of miR16 may protect against H/Rinduced injury partially by targeting CIAPIN1 and the NFkappaB signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0009055 electron transfer activity;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5XID1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XII0-1", "uniprot_id": "EPDR1_RAT", "mass": 25639.0, "length": 224, "protein_name": "Mammalian ependymin-related protein 1", "gene_name": "Epdr1", "organism": "Rat", "refseq_name": "mammalian ependymin-related protein 1 isoform 1 precursor", "refseq_ac": "NP_001007626", "gene_names_uniprotkb": "Epdr1; Epdr2; Merp1; Merp2", "gene_names_refseq": "Epdr1; Epdr2; MERP2", "protein_names_uniprotkb": "Mammalian ependymin-related protein 1; MERP-1", "protein_names_refseq": "MERP-1; ependymin related protein 1; mammalian ependymin-related protein 1 isoform 1 precursor; mammalian ependymin-related protein 1; upregulated in colorectal cancer gene 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:291180)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16954209;24090084;38843836", "class_list": "", "function": "A novel density shift method was used to demonstrate that EPDR resides in the lysosome., [RefSeq, PubMed]; Binds anionic lipids and gangliosides at acidic pH., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1905573 ganglioside GM1 binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:1990764 myofibroblast contraction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5XII0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIJ4-1", "uniprot_id": "MIMS1_RAT", "mass": 31474.0, "length": 273, "protein_name": "Mitochondrial inner membrane scaffold 1", "gene_name": "Mims1", "organism": "Rat", "refseq_name": "protein FAM210A", "refseq_ac": "NP_001007689", "gene_names_uniprotkb": "Mims1; Fam210a", "gene_names_refseq": "Fam210a; Mims1; RGD1359600", "protein_names_uniprotkb": "Mitochondrial inner membrane scaffold 1; Protein FAM210A", "protein_names_refseq": "LEA_4 domain containing protein RGD1359600; family with sequence similarity 210, member A; protein FAM210A; uncharacterized protein C18orf19 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:307343)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Mitochondrial inner membrane protein essential for mitochondrial homeostasis, structural integrity, and cellular metabolism. Regulates mitochondrial translation by modulating protein synthesis of mitochondrial DNA-encoded genes. Plays a critical role in skeletal muscle mass and strength by regulating mitochondrial density, function, and protein synthesis. In brown adipose tissue, regulates mitochondrial cristae remodeling in response to cold stress by interacting with mitochondrial protease YME1L1 and enhancing its proteolytic activity, promoting OMA1 degradation and regulating OPA1 processing. Required for cardiac mitochondrial homeostasis and normal cardiomyocyte contractile function. In skeletal muscle, positively regulates myoblast differentiation by enhancing expression of myogenic factors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIL8-1", "uniprot_id": "DNAI1_RAT", "mass": 80073.0, "length": 705, "protein_name": "Dynein axonemal intermediate chain 1", "gene_name": "Dnai1", "organism": "Rat", "refseq_name": "dynein axonemal intermediate chain 1", "refseq_ac": "NP_001019513", "gene_names_uniprotkb": "Dnai1", "gene_names_refseq": "Dnai1; Dnaic1", "protein_names_uniprotkb": "Dynein axonemal intermediate chain 1; Axonemal dynein intermediate chain 1", "protein_names_refseq": "axonemal dynein intermediate chain 1; dynein axonemal intermediate chain 1; dynein intermediate chain 1, axonemal", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia 1 (Disease Ontology:DOID:0110594)", "pathway": " (rno:500442)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Part of the dynein complex of respiratory cilia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007507 heart development;GO:0030317 flagellated sperm motility;GO:0008286 insulin receptor signaling pathway;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIS2-1", "uniprot_id": "CPTP_RAT", "mass": 24522.0, "length": 216, "protein_name": "Ceramide-1-phosphate transfer protein", "gene_name": "Cptp", "organism": "Rat", "refseq_name": "ceramide-1-phosphate transfer protein isoform a", "refseq_ac": "NP_001007704", "gene_names_uniprotkb": "Cptp; Gltpd1", "gene_names_refseq": "Cptp; Gltpd1", "protein_names_uniprotkb": "Ceramide-1-phosphate transfer protein; CPTP; Glycolipid transfer protein domain-containing protein 1", "protein_names_refseq": "ceramide-1-phosphate transfer protein isoform a; glycolipid transfer protein domain containing 1; glycolipid transfer protein domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:313771); (R-RNO-9845576)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0010008 endosome membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0035627 ceramide transport;GO:0032691 negative regulation of interleukin-1 beta production;GO:0010507 negative regulation of autophagy;GO:1902389 ceramide 1-phosphate transport;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XIU1-1", "uniprot_id": "ABTB1_RAT", "mass": 54065.0, "length": 478, "protein_name": "Ankyrin repeat and BTB/POZ domain-containing protein 1", "gene_name": "Abtb1", "organism": "Rat", "refseq_name": "ankyrin repeat and BTB/POZ domain-containing protein 1", "refseq_ac": "NP_001005902", "gene_names_uniprotkb": "Abtb1", "gene_names_refseq": "Abtb1", "protein_names_uniprotkb": "Ankyrin repeat and BTB/POZ domain-containing protein 1", "protein_names_refseq": "ankyrin repeat and BTB (POZ) domain containing 1; ankyrin repeat and BTB/POZ domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:297432)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XJW2-1", "uniprot_id": "G45IP_RAT", "mass": 26467.0, "length": 228, "protein_name": "Large ribosomal subunit protein mL64", "gene_name": "Gadd45gip1", "organism": "Rat", "refseq_name": "large ribosomal subunit protein mL64", "refseq_ac": "NP_001093974", "gene_names_uniprotkb": "Gadd45gip1; Mrpl59", "gene_names_refseq": "Gadd45gip1; MRP-L59", "protein_names_uniprotkb": "Large ribosomal subunit protein mL64; 39S ribosomal protein L59, mitochondrial; Growth arrest and DNA damage-inducible proteins-interacting protein 1; MRP-L59", "protein_names_refseq": "39S ribosomal protein L59, mitochondrial; growth arrest and DNA damage-inducible proteins-interacting protein 1; growth arrest and DNA-damage-inducible, gamma interacting protein 1; large ribosomal subunit protein mL64", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:288916); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XJW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5Y4N8-1", "uniprot_id": "AGRE1_RAT", "mass": 102308.0, "length": 932, "protein_name": "Adhesion G protein-coupled receptor E2", "gene_name": "Adgre1", "organism": "Rat", "refseq_name": "adhesion G protein-coupled receptor E2 precursor", "refseq_ac": "NP_001007558", "gene_names_uniprotkb": "Adgre1; Emr1", "gene_names_refseq": "Adgre1; Emr1", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor E2; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor", "protein_names_refseq": "EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; adhesion G protein-coupled receptor E2 precursor; adhesion G protein-coupled receptor E2; cell surface glycoprotein EMR1", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:316137); (R-RNO-373080)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15578266", "class_list": "", "function": "Orphan receptor involved in cell adhesion and probably in cell-cell interactions involved specifically cells of the immune system. May play a role in regulatory T-cells (Treg) development., [UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0002250 adaptive immune response;GO:0071560 cellular response to transforming growth factor beta stimulus;GO:0071356 cellular response to tumor necrosis factor", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5Y4N8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62632-1", "uniprot_id": "FSTL1_RAT", "mass": 34622.0, "length": 306, "protein_name": "Follistatin-related protein 1", "gene_name": "Fstl1", "organism": "Rat", "refseq_name": "follistatin-related protein 1 precursor", "refseq_ac": "NP_077345", "gene_names_uniprotkb": "Fstl1; Frp", "gene_names_refseq": "Frp; Fstl1; Fstl", "protein_names_uniprotkb": "Follistatin-related protein 1; Follistatin-like protein 1", "protein_names_refseq": "follistatin-like protein 1; follistatin-related protein 1 precursor; follistatin-related protein 1", "tax_id": 10116, "disease": "pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:79210); (R-RNO-201451); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12493714;12591166;12645077;28188034;31139662;35585770;35766911;38436106;7957230", "class_list": "", "function": "Aerobic exercise training-induced follistatin-like 1 secretion in the skeletal muscle is related to arterial stiffness via arterial NO production in obese rats., [RefSeq, PubMed]; Characterization of follistatin-related gene: effects of estrous cycle stage and pregnancy on its messenger RNA expression in reproductive tissues., [RefSeq, PubMed]; Circ_TLK1 knockdown alleviates oxygen-glucose deprivation/reoxygenation-induced PC12 cell injury by regulating microRNA-136-5p/follistatin like-1 axis., [RefSeq, PubMed]; Decreased expression of Fstl1 in alveolar epithelium may disrupt alveolarization and pulmonary surfactant production, thus contributing to the development of pulmonary hypertension in the nitrofen-induced rat congenital diaphragmatic hernia model., [RefSeq, PubMed]; Expression levels of FLRG protein are significantly increased in brain damaged regions after penetrating injury; specifically, FLRG protein is colocalized in glial fibrillary acidic protein-positive reactive astroglial cells., [RefSeq, PubMed]; FSTL1 plays a protective role in myocardial IRI by regulating autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway., [RefSeq, PubMed]; Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0043542 endothelial cell migration;GO:0030510 regulation of BMP signaling pathway;GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q62632-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62662-1", "uniprot_id": "FRK_RAT", "mass": 58166.0, "length": 506, "protein_name": "Tyrosine-protein kinase FRK", "gene_name": "Frk", "organism": "Rat", "refseq_name": "tyrosine-protein kinase FRK", "refseq_ac": "NP_077344", "gene_names_uniprotkb": "Frk; Gask", "gene_names_refseq": "Frk", "protein_names_uniprotkb": "Tyrosine-protein kinase FRK; 2.7.10.2; FYN-related kinase; GASK; GTK; Gastrointestinal-associated kinase; Gastrointestinal-associated tyrosine kinase", "protein_names_refseq": "GASK; GTK; fyn-related kinase; gastrointestinal-associated kinase; gastrointestinal-associated tyrosine kinase; src related tyrosine kinase; tyrosine-protein kinase FRK", "tax_id": 10116, "disease": "intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:79209); (R-RNO-6798695); (R-RNO-8948751)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12725532;17959796;22673903;8167158;8760296", "class_list": "", "function": "Fyn kinase is associated with sodium channels in brain neurons and can modulate Na(v)1.2 channels by tyrosine phosphorylation after activation of TrkB/p75 neurotrophin receptor signaling by brain-derived neurotrophic factor (BDNF)., [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.1;2.7.10.1;1.11.2.2;2.7.10.2;3.4.21.4;3.6.5.2;3.4.16.-;2.7.12.2;2.7.1.40;3.2.1.-;5.3.4.1;1.1.1.205;3.2.1.23;2.3.2.5;5.3.99.3;2.7.11.1;1.11.1.27;3.1.1.4;2.3.1.23;2.7.1.35;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.4.24.34;3.2.1.17;3.2.1.31;3.5.3.1;2.3.1.16;2.3.1.9;2.3.1.155;2.7.11.13;2.3.3.8;3.2.1.51;3.4.21.20;1.6.2.2;3.5.3.15;3.4.23.5;3.5.1.26;2.7.10.4;1.4.3.22;1.4.3.-;3.6.4.6;3.1.6.12;2.4.1.1;2.7.11.24;3.1.27.-;3.4.14.1;2.7.1.32;2.7.1.82;3.1.21.-;3.1.6.4;3.1.6.8;1.6.5.5;3.5.1.3;3.6.1.-;3.4.19.9;2.7.11.23;3.2.1.52;1.8.3.2;6.3.4.21;3.2.1.166;3.6.1.6;3.2.1.18;3.4.14.2;3.4.18.1", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62662-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62737-1", "uniprot_id": "CY24A_RAT", "mass": 20750.0, "length": 192, "protein_name": "Cytochrome b-245 light chain", "gene_name": "Cyba", "organism": "Rat", "refseq_name": "cytochrome b-245 light chain", "refseq_ac": "NP_077074", "gene_names_uniprotkb": "Cyba", "gene_names_refseq": "Cyba; Phox; p22-phox", "protein_names_uniprotkb": "Cytochrome b-245 light chain; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox", "protein_names_refseq": "alpha-subunit p22; cytochrome b(558) alpha chain; cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; cytochrome b558 alpha-subunit; cytochrome b558 subunit alpha; neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22phox; superoxide-generating NADPH oxidase light chain subunit", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); autosomal recessive chronic granulomatous disease 4 (Disease Ontology:DOID:0070193); hypertension (Disease Ontology:DOID:10763); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); phagocyte bactericidal dysfunction (Disease Ontology:DOID:3262); chronic granulomatous disease (Disease Ontology:DOID:3265); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:79129); (R-RNO-1222556); (R-RNO-1236973); (R-RNO-3299685); (R-RNO-4420097); (R-RNO-5668599); (R-RNO-6798695); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013423)", "pathway_count": 10, "publication_count": 8, "publication_id_list": "10938010;15322091;22673903;27824157;28669019;31030942;35786680;7578211", "class_list": "", "function": "Impaired intestinal expression of Dcyt-b and DMT-1 might be associated with the reduction of an iron uptake in CKD. Taken together, impaired these intestinal iron transporters may become a novel therapeutic target for cardio-renal anemia syndrome., [RefSeq, PubMed]; Inhibition of autophagy with expression of NADPH oxidase subunit p22phox in preneoplastic lesions in a high-fat diet and streptozotocin-related hepatocarcinogenesis rat model., [RefSeq, PubMed]; P22phox has a role in sympathetic regulation of blood pressure in stroke-prone spontaneously hypertensive rats Publication Status: Online-Only, [RefSeq, PubMed]; Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor. Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. Aassociates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; The role of p22phox in the Angiotensin-II -induced proliferation and migration of the vascular smooth muscle cells via the H2O2-ERK1/2/AKT-KLF4 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ER27", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0017124 SH3 domain binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0020037 heme binding", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0006954 inflammatory response;GO:0030307 positive regulation of cell growth;GO:0032930 positive regulation of superoxide anion generation;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62737-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62805-1", "uniprot_id": "GALR1_RAT", "mass": 38862.0, "length": 346, "protein_name": "Galanin receptor type 1", "gene_name": "Galr1", "organism": "Rat", "refseq_name": "galanin receptor type 1", "refseq_ac": "NP_037090", "gene_names_uniprotkb": "Galr1; Galnr1; Galnr", "gene_names_refseq": "Galnr1; Galr1", "protein_names_uniprotkb": "Galanin receptor type 1; GAL1-R; GALR-1", "protein_names_refseq": "GAL1-R; GALR-1; galanin receptor type 1", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); opioid abuse (Disease Ontology:DOID:11206); opiate dependence (Disease Ontology:DOID:2559)", "pathway": " (rno:50577); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "29127424;29852172;34086200;34108238;8750821", "class_list": "", "function": "Activation of Galanin Receptor 1 with M617 Attenuates Neuronal Apoptosis via ERK/GSK-3beta/TIP60 Pathway After Subarachnoid Hemorrhage in Rats. Erratum:[Neurotherapeutics. 2024 Apr;21(3):e00358. doi: 10.1016/j.neurot.2024.e00358. PMID: 38641459], [RefSeq, PubMed]; Involvement of Scratch2 in GalR1-mediated depression-like behaviors in the rat ventral periaqueductal gray., [RefSeq, PubMed]; Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity., [UniProtKB, UniProtKB, PubMed]; The inhibitory effect of galanin on locus coeruleus neurons is mediated by GALR1 via Gi/o proteins, which activate GIRK channels., [RefSeq, PubMed]; These results illustrated that galanin induced antinociception in CeA in normal rats and rats with neuropathy, and there is an up-regulation of GalR1 expression in rats with neuropathy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004966 galanin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62805-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62825-1", "uniprot_id": "EXOC3_RAT", "mass": 86497.0, "length": 755, "protein_name": "Exocyst complex component 3", "gene_name": "Exoc3", "organism": "Rat", "refseq_name": "exocyst complex component 3", "refseq_ac": "NP_001020135", "gene_names_uniprotkb": "Exoc3; Ahrr; Sec6l1; Sec6", "gene_names_refseq": "Exoc3; Sec6l1; Sec6; rSec6", "protein_names_uniprotkb": "Exocyst complex component 3; Exocyst complex component Sec6; rSec6", "protein_names_refseq": "SEC6-like 1; exocyst complex component 3; exocyst complex component Sec6", "tax_id": 10116, "disease": "", "pathway": " (rno:252881); (R-RNO-264876); (R-RNO-5620916)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12954101;16181645;17827149;7568183;9405631", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB, UniProtKB, UniProtKB]; Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with AHR for heterodimer formation with ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of a variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQU2", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm;GO:0030496 midbody;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0051601 exocyst localization;GO:0015031 protein transport;GO:0006887 exocytosis;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62825-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62878-1", "uniprot_id": "3BHS4_RAT", "mass": 41957.0, "length": 373, "protein_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4", "gene_name": "Hsd3b6", "organism": "Rat", "refseq_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4", "refseq_ac": "NP_058961", "gene_names_uniprotkb": "Hsd3b6", "gene_names_refseq": "Hsd3b1; Hsd3b2l1; Hsd3b2; Hsd3b6", "protein_names_uniprotkb": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV; 3-beta-HSD IV; 3-beta-hydroxy-5-ene steroid dehydrogenase; Delta-5-3-ketosteroid isomerase; Progesterone reductase", "protein_names_refseq": "3 beta-hydroxysteroid dehydrogenase 6; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV; 3-beta-HSD IV; Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6; hydroxysteroid dehydrogenase-6 delta<5>-3-beta", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); polycystic ovary syndrome (Disease Ontology:DOID:11612); hyperprolactinemia (Disease Ontology:DOID:12700)", "pathway": " (rno:29632); (R-RNO-193048); (R-RNO-193993); (R-RNO-194002)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "17257522;19071209;7690038", "class_list": "", "function": "3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids., [UniProtKB]; Lycopene protects against PCB-induced changes in Leydig cellular StAR protein, cytochrome P450 scc expression and activity of 3beta-HSD., [RefSeq, PubMed]; The present studies showed differences in AR and 3beta-HSD distribution within various generations of corpora lutea (CL) and within particular regions of the same young CL., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVK0", "ec_number_list": "1.1.1.270;1.1.1.145;5.3.3.1;1.1.1.210", "go_molecular_function": "GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity;GO:0004769 steroid Delta-isomerase activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010288 response to lead ion;GO:0021766 hippocampus development;GO:0046686 response to cadmium ion;GO:0006700 C21-steroid hormone biosynthetic process;GO:0006694 steroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62878-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62893-1", "uniprot_id": "AMHR2_RAT", "mass": 59749.0, "length": 557, "protein_name": "Anti-Muellerian hormone type-2 receptor", "gene_name": "Amhr2", "organism": "Rat", "refseq_name": "anti-Muellerian hormone type-2 receptor precursor", "refseq_ac": "NP_112260", "gene_names_uniprotkb": "Amhr2", "gene_names_refseq": "Amhr2; C14; MISRII; MRII", "protein_names_uniprotkb": "Anti-Muellerian hormone type-2 receptor; 2.7.11.30; AMH type II receptor; Anti-Muellerian hormone type II receptor; C14; MIS type II receptor; MISRII; MRII", "protein_names_refseq": "AMH type II receptor; MIS type II receptor; anti-Muellerian hormone type II receptor; anti-Muellerian hormone type-2 receptor precursor; anti-Muellerian hormone type-2 receptor; anti-Mullerian hormone receptor type 11 SV1; anti-Mullerian hormone receptor, type II; anti-Mullerian hormone type 2 receptor", "tax_id": 10116, "disease": "persistent Mullerian duct syndrome (Disease Ontology:DOID:0050791); leiomyosarcoma (Disease Ontology:DOID:1967); dysgerminoma (Disease Ontology:DOID:4441)", "pathway": " (rno:29530); (R-RNO-201451)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10570158;16329036;16687449;23624077;8119126;8536608", "class_list": "", "function": "Data suggest that Mullerian inhibiting substance (MIS) initiates an epithelial-to-mesenchymal transition of MISRI receptor-expressing cells and specifies the components of the receptor/SMAD8 signaling pathway by regulating their expression., [RefSeq, PubMed]; Examined the presence of AMH receptor type II (AMHR-II) in fetal Leydig cells (FLC) and cells in the adult Leydig cells lineage in the postnatal testis; presence of AMHR-II in postnatal FLC suggests a possible role by AMH on FLC, [RefSeq, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Physiological function(s) of type 2 anti-Mullerian hormone receptor, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q63045;Q9R0A7", "ec_number_list": "2.7.11.30", "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0042562 hormone binding;GO:0005024 transforming growth factor beta receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0008584 male gonad development;GO:0071363 cellular response to growth factor stimulus;GO:0030509 BMP signaling pathway;GO:0007548 sex differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62893-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63003-1", "uniprot_id": "5E5_RAT", "mass": 86831.0, "length": 825, "protein_name": "5E5 antigen", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "5E5 antigen", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8537300", "class_list": "", "function": "Might have DNA-binding ability., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63003-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63010-1", "uniprot_id": "EST5_RAT", "mass": 62495.0, "length": 561, "protein_name": "Liver carboxylesterase B-1", "gene_name": "", "organism": "Rat", "refseq_name": "liver carboxylesterase B-1 precursor", "refseq_ac": "NP_001019536", "gene_names_uniprotkb": "", "gene_names_refseq": "Cesl1", "protein_names_uniprotkb": "Liver carboxylesterase B-1; 3.1.1.1; Liver microsomal carboxylesterase", "protein_names_refseq": "liver carboxylesterase B-1 precursor; liver carboxylesterase B-1; liver microsomal carboxylesterase", "tax_id": 10116, "disease": "", "pathway": " (rno:501232)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7961958;8597091", "class_list": "", "function": "Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6AYA3;Q9QUX6", "ec_number_list": "3.1.1.1;3.1.1.-;3.1.1.67", "go_molecular_function": "GO:0050253 retinyl-palmitate esterase activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005811 lipid droplet", "go_biological_process": "GO:0019626 short-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63010-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63108-1", "uniprot_id": "EST1E_RAT", "mass": 61715.0, "length": 561, "protein_name": "Carboxylesterase 1E", "gene_name": "Ces1e", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ces1e; Ces1", "gene_names_refseq": "", "protein_names_uniprotkb": "Carboxylesterase 1E; 3.1.1.1; Carboxyesterase ES-3; ES-HTEL; Egasyn; Liver carboxylesterase 3; pI 5.5 esterase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "12230550;7945287", "class_list": "", "function": "Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters (PubMed:12230550)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.1;3.1.1.88;3.1.1.-;3.1.1.28;3.1.1.23;3.1.1.79;3.1.1.67;3.1.1.3", "go_molecular_function": "GO:0052689 carboxylic ester hydrolase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005811 lipid droplet;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0019626 short-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63108-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63113-1", "uniprot_id": "FXYD4_RAT", "mass": 9084.0, "length": 87, "protein_name": "FXYD domain-containing ion transport regulator 4", "gene_name": "Fxyd4", "organism": "Rat", "refseq_name": "FXYD domain-containing ion transport regulator 4 precursor", "refseq_ac": "NP_001355592", "gene_names_uniprotkb": "Fxyd4", "gene_names_refseq": "Chif; Fxyd4", "protein_names_uniprotkb": "FXYD domain-containing ion transport regulator 4; CHIF; Channel-inducing factor; Corticosteroid-induced protein", "protein_names_refseq": "FXYD domain-containing ion transport regulator 4 precursor; channel-inducing factor; corticosteroid-induced protein", "tax_id": 10116, "disease": "", "pathway": " (rno:64190); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11181413;11483503;16476578;16757733;17567018;18000745;7597086;8843704", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Increases the apparent affinity of the transporter for Na(+) and increases NKA activity., [UniProtKB, PubMed, UniProtKB, UniProtKB]; CHIF drastically modulates the KCNQ1 current; in the presence of CHIF, the KCNQ1 channels open at all membrane potentials., [RefSeq, PubMed]; Structures of the FXYD proteins (with emphasis on 1-4), as well as their dynamics and their associations with the lipid bilayer membrane Review article, [RefSeq, PubMed]; The unchanged levels of FXYD2 and FXYD4 proteins suggest that they are not primary determinants for urine electrolyte composition during NaCl depletion, [RefSeq, PubMed]; This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0017080 sodium channel regulator activity;GO:0005267 potassium channel activity;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005890 sodium:potassium-exchanging ATPase complex;GO:0016020 membrane", "go_biological_process": "GO:0006812 monoatomic cation transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane;GO:0071805 potassium ion transmembrane transport;GO:0043269 regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63113-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63244-1", "uniprot_id": "FOXQ1_RAT", "mass": 41079.0, "length": 399, "protein_name": "Forkhead box protein Q1", "gene_name": "Foxq1", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Foxq1; Hfh1", "gene_names_refseq": "", "protein_names_uniprotkb": "Forkhead box protein Q1; HFH-1; HNF-3/forkhead-like protein 1; Hepatocyte nuclear factor 3 forkhead homolog 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:64826)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15326124;7683413", "class_list": "", "function": "Plays a role in hair follicle differentiation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0031069 hair follicle morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63244-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63413-1", "uniprot_id": "DX39B_RAT", "mass": 49035.0, "length": 428, "protein_name": "Spliceosome RNA helicase Ddx39b", "gene_name": "Ddx39b", "organism": "Rat", "refseq_name": "spliceosome RNA helicase Ddx39b", "refseq_ac": "NP_579834", "gene_names_uniprotkb": "Ddx39b; Bat1a; Bat1; Uap56", "gene_names_refseq": "Bat1a; Bat1; Ddx39b; p47", "protein_names_uniprotkb": "Spliceosome RNA helicase Ddx39b; 3.6.4.13; 56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; DEAD box protein Uap56", "protein_names_refseq": "56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; D17H6S81E-1; D20H6S81e; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; DEAD box protein UAP56; DEAD-box helicase 39B; HLA-B associated transcript 1; HLA-B-associated transcript 1A; Nuclear RNA helicase; spliceosome RNA helicase Bat1; spliceosome RNA helicase Ddx39b", "tax_id": 10116, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:114612); (R-RNO-159236); (R-RNO-72163); (R-RNO-9013418)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11904681;1618789;23246467", "class_list": "", "function": "Involved in nuclear export of spliced and unspliced mRNA. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B. Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability., [UniProtKB, UniProtKB]; Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly., [UniProtKB, UniProtKB]; These findings suggest that UAP56 is a regulator of VSMC proliferation and identify UAP56 as a target for preventing vascular proliferative disease., [RefSeq, PubMed]; To determine whether the rat possesses an H2-D orthologue, we sequenced a cosmid clone that contains rat Bat1 and an adjacent class I gene, RT1.46 (l)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811A6;Q8R2G9", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;5.2.1.8;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.6;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.1.4.-;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:0001889 liver development;GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63413-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63471-1", "uniprot_id": "BPIA2_RAT", "mass": 24529.0, "length": 235, "protein_name": "BPI fold-containing family A member 2", "gene_name": "Bpifa2", "organism": "Rat", "refseq_name": "BPI fold-containing family A member 2 precursor", "refseq_ac": "NP_434695", "gene_names_uniprotkb": "Bpifa2; Psp", "gene_names_refseq": "Bpifa2e; Bpifa2; Psp", "protein_names_uniprotkb": "BPI fold-containing family A member 2; Neonatal submandibular gland protein; PSP; Parotid secretory protein", "protein_names_refseq": "BPI fold containing family A, member 2E; BPI fold-containing family A member 2 precursor; neonatal submandibular gland protein; parotid secretory protein; short palate, lung and nasal epithelium carcinoma-associated protein 2", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); ductal carcinoma in situ (Disease Ontology:DOID:0060074); lethal congenital contracture syndrome 2 (Disease Ontology:DOID:0060560); neuronal intestinal dysplasia type A (Disease Ontology:DOID:0080679); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); urinary bladder cancer (Disease Ontology:DOID:11054); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carcinoma (Disease Ontology:DOID:305); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); stomach carcinoma (Disease Ontology:DOID:5517); median neuropathy (Disease Ontology:DOID:571); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:50585); (R-RNO-6803157)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12435394;1370829;19642100;9461541", "class_list": "", "function": "Has strong antibacterial activity against P.aeruginosa., [UniProtKB, UniProtKB]; PSP co-fractionates with chromogranin A but not with secreted alkaline phosphatase; its sorting is not cell-type specific but the precise mechanism of its sorting is unknown, [RefSeq, PubMed]; Results suggest that at least two pathways--granular and vesicular--are responsible for the generation of the two peptides, PSPFr-A and PSPFr-B, from rat parotid secretory protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63471-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63639-1", "uniprot_id": "AL1A2_RAT", "mass": 56640.0, "length": 518, "protein_name": "Retinal dehydrogenase 2", "gene_name": "Aldh1a2", "organism": "Rat", "refseq_name": "retinal dehydrogenase 2", "refseq_ac": "NP_446348", "gene_names_uniprotkb": "Aldh1a2; Raldh2", "gene_names_refseq": "Aldh1a2; Raldh-2", "protein_names_uniprotkb": "Retinal dehydrogenase 2; 1.2.1.36; ALDH1A2; Aldehyde dehydrogenase family 1 member A2; RALDH 2; RALDH(II); RalDH2; Retinaldehyde-specific dehydrogenase type 2", "protein_names_refseq": "RALDH 2; RalDH(II); aldehyde dehydrogenase 1A2; aldehyde dehydrogenase family 1 member A2; aldehyde dehydrogenase family 1, subfamily A2; ralDH2; retinal dehydrogenase 2; retinal dehydrogenase, type II; retinaldehyde-specific dehydrogenase type 2", "tax_id": 10116, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:116676); (R-RNO-5365859)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10320326;8663198", "class_list": "", "function": "Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity) (PubMed:8663198). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (By similarity). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (PubMed:8663198). Lacks activity with benzaldehyde, acetaldehyde and octanal (PubMed:8663198). Displays complete lack of activity with citral (PubMed:8663198)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZY8", "ec_number_list": "1.2.1.36;1.2.1.19;1.2.1.3;1.2.1.28;1.1.1.-;1.1.1.62;1.1.1.105;1.7.1.-", "go_molecular_function": "GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0016918 retinal binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001889 liver development;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63639-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64057-1", "uniprot_id": "AL7A1_RAT", "mass": 58749.0, "length": 539, "protein_name": "Alpha-aminoadipic semialdehyde dehydrogenase", "gene_name": "Aldh7a1", "organism": "Rat", "refseq_name": "alpha-aminoadipic semialdehyde dehydrogenase", "refseq_ac": "NP_001258034", "gene_names_uniprotkb": "Aldh7a1; Ald7a1", "gene_names_refseq": "Aldh7a1; antiquitin", "protein_names_uniprotkb": "Alpha-aminoadipic semialdehyde dehydrogenase; 1.2.1.31; 1.2.1.3; 1.2.1.8; Aldehyde dehydrogenase family 7 member A1; Alpha-AASA dehydrogenase; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase", "protein_names_refseq": "P6c dehydrogenase; aldehyde dehydrogenase family 7 member A1; alpha-AASA dehydrogenase; alpha-aminoadipic semialdehyde dehydrogenase; antiquitin-1; betaine aldehyde dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenease", "tax_id": 10116, "disease": "early-onset vitamin B6-dependent epilepsy 4 (Disease Ontology:DOID:0070519); pyridoxine-dependent epilepsy (Disease Ontology:DOID:0080768); epilepsy (Disease Ontology:DOID:1826); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:291450); (R-RNO-6798163); (R-RNO-71064)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "8088832;9417906", "class_list": "", "function": "Aldehyde dehydrogenase enzyme that mediates important protective effects. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism in the brain by mediating the conversion of L-aminoadipate-semialdehyde ((S)-2-amino-6-oxohexanoate) to L-2-aminoadipate. Acts as a key inhibitor of ferroptosis both by generating membrane NADH and decreasing the level of reactive aldehydes. Recruited to plasma membrane in response to ferroptotic stress and phosphorylation by AMPK, generating membrane NADH to support AIFM2/FSP1 activity, an essential ferroptosis suppressor protein. Also directly inhibits ferroptosis by decreasing lipid peroxidation via consumption of reactive aldehydes, such as 4-hydroxynonenal (4-HNE) and malonaldehyde. Also acts as a regulator of cellular energy homeostasis in response to cellular energy stress, such as starvation and hypoxia, by inhibiting COPI-mediated intracellular transport, thereby reducing cellular energy consumption. Involved in cellular defense against hyperosmotic stress by metabolizing betaine aldehyde to betaine, an important cellular osmolyte and methyl donor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.2.1.5;1.2.1.3;1.2.1.94;1.2.1.36;1.2.1.19;1.2.1.28;1.2.1.7;1.2.1.48;1.2.1.31;1.2.1.8;1.7.1.-;1.2.1.47;1.2.1.46", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004043 L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity;GO:0008802 betaine-aldehyde dehydrogenase (NAD+) activity;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006554 lysine catabolic process;GO:0097009 energy homeostasis;GO:0008333 endosome to lysosome transport;GO:0019285 glycine betaine biosynthetic process from choline;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64057-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q641X1-1", "uniprot_id": "ANR61_RAT", "mass": 46320.0, "length": 418, "protein_name": "Ankyrin repeat domain-containing protein 61", "gene_name": "Ankrd61", "organism": "Rat", "refseq_name": "ankyrin repeat domain-containing protein 61", "refseq_ac": "NP_001037762", "gene_names_uniprotkb": "Ankrd61", "gene_names_refseq": "Ankrd61", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 61", "protein_names_refseq": "ankyrin repeat domain-containing protein 61", "tax_id": 10116, "disease": "", "pathway": " (rno:689907)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q641X1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q641Y8-1", "uniprot_id": "DDX1_RAT", "mass": 82497.0, "length": 740, "protein_name": "ATP-dependent RNA helicase DDX1", "gene_name": "Ddx1", "organism": "Rat", "refseq_name": "ATP-dependent RNA helicase DDX1", "refseq_ac": "NP_445866", "gene_names_uniprotkb": "Ddx1", "gene_names_refseq": "Ddx1", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX1; 3.6.4.13; DEAD box protein 1", "protein_names_refseq": "ATP-dependent RNA helicase DDX1; DEAD (Asp-Glu-Ala-Asp) box helicase 1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box protein 1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1; DEAD/H-box helicase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:84474)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;30295850;38843836", "class_list": "", "function": "Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. It is also an accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. Cooperates with ZBTB8OS (also known as archease) for the guanylylation of RTCB, a key intermediate step in activation of the tRNA ligase. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA., [UniProtKB, UniProtKB, UniProtKB]; DDX1-mediated repression of insulin translation worsens the situation of insulin resistance and contributes to the elevation of blood glucose levels in obese animals, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.6.4.13;3.6.4.12;2.7.11.1;3.6.1.5;3.6.4.10;3.6.4.-;2.3.2.27;5.6.2.4;3.6.5.-;5.6.2.-;3.1.-.-;2.7.7.7;2.7.7.49;3.1.13.1;4.2.99.18;7.6.2.2;7.6.2.3;7.6.2.-;5.6.1.6;7.2.2.-;3.6.1.15;3.6.4.6;3.1.3.1;3.9.1.1;6.1.1.12;3.6.1.-;2.7.4.3;3.1.4.-;3.4.24.-;3.6.-.-;3.4.21.53;5.6.2.5", "go_molecular_function": "GO:0033677 DNA/RNA helicase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:1903608 protein localization to cytoplasmic stress granule;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q641Y8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64273-1", "uniprot_id": "KCNJ2_RAT", "mass": 48200.0, "length": 427, "protein_name": "Inward rectifier potassium channel 2", "gene_name": "Kcnj2", "organism": "Rat", "refseq_name": "inward rectifier potassium channel 2", "refseq_ac": "NP_058992", "gene_names_uniprotkb": "Kcnj2; Irk1", "gene_names_refseq": "Kcnj2; Kir2.1", "protein_names_uniprotkb": "Inward rectifier potassium channel 2; IRK-1; Inward rectifier K(+) channel Kir2.1; Potassium channel, inwardly rectifying subfamily J member 2; RBL-IRK1", "protein_names_refseq": "IRK-1; RBL-IRK1; inward rectifier K(+) channel Kir2.1; inward rectifier potassium channel 2; potassium channel, inwardly rectifying subfamily J member 2; potassium voltage-gated channel subfamily J member 2", "tax_id": 10116, "disease": "Andersen-Tawil syndrome (Disease Ontology:DOID:0050434); familial atrial fibrillation (Disease Ontology:DOID:0050650); short QT syndrome (Disease Ontology:DOID:0050793); atrial fibrillation (Disease Ontology:DOID:0060224); EAST syndrome (Disease Ontology:DOID:0060484); familial periodic paralysis (Disease Ontology:DOID:1029); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:29712); (R-RNO-1296041); (R-RNO-1296053); (R-RNO-5576886); (R-RNO-997272)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "14960569;21209095;31391240;32449050;32554946;34592781;35856410;7603835;9486652;9533862", "class_list": "", "function": "Altering integrin engagement regulates membrane localization of Kir2.1 channels. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of KIR2.1 decreases pulmonary artery smooth muscle cell proliferation and migration., [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (PubMed:7603835, PubMed:9486652). Can be blocked by extracellular barium and cesium. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Magnesium Deficiency Causes Transcriptional Downregulation of Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT Interval Prolongation., [RefSeq, PubMed]; Oscillating shear stress mediates mesenchymal transdifferentiation of EPCs by the Kir2.1 channel., [RefSeq, PubMed]; Slight up-regulation of Kir2.1 channel promotes endothelial progenitor cells to transdifferentiate into a pericyte phenotype by Akt/mTOR/Snail pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0086011 membrane repolarization during action potential;GO:0014861 regulation of skeletal muscle contraction via regulation of action potential;GO:0015693 magnesium ion transport;GO:0051289 protein homotetramerization;GO:0060306 regulation of membrane repolarization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64273-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q642A7-1", "uniprot_id": "F151A_RAT", "mass": 67187.0, "length": 608, "protein_name": "Protein FAM151A", "gene_name": "Fam151a", "organism": "Rat", "refseq_name": "protein FAM151A", "refseq_ac": "NP_001005558", "gene_names_uniprotkb": "Fam151a", "gene_names_refseq": "Fam151a", "protein_names_uniprotkb": "Protein FAM151A", "protein_names_refseq": "protein FAM151A", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (rno:313430)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q642A7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64573-1", "uniprot_id": "EST1F_RAT", "mass": 62308.0, "length": 561, "protein_name": "Liver carboxylesterase 1F", "gene_name": "Ces1f", "organism": "Rat", "refseq_name": "liver carboxylesterase 1F precursor", "refseq_ac": "NP_001096829", "gene_names_uniprotkb": "Ces1f", "gene_names_refseq": "Ces1f", "protein_names_uniprotkb": "Liver carboxylesterase 1F; 3.1.1.1; Carboxyesterase ES-4; Kidney microsomal carboxylesterase; Microsomal palmitoyl-CoA hydrolase", "protein_names_refseq": "carboxyesterase ES-4; carboxylesterase ES-4; kidney microsomal carboxylesterase; liver carboxylesterase 1F precursor; liver carboxylesterase 1F; liver carboxylesterase 4; microsomal palmitoyl-CoA hydrolase", "tax_id": 10116, "disease": "", "pathway": " (rno:100125372)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12230550;21937439;7961958;8611161", "class_list": "", "function": "Establish ES-4 as a bona fide endogenous nCEH that can account for the majority of cholesteryl ester hydrolysis in transformed rat hepatic cells and primary rat hepatocytes., [RefSeq, PubMed]; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters (PubMed:12230550). Hydrolyzes p-nitrophenyl butyrate (PNPB), triacylglycerol and monoacylglycerol. Shows higher activity against PNPB, a short-chain fatty acid ester, than against triolein, a long-chain fatty acid ester. Shows no detectable activity against diacylglycerol, cholesterol ester or phospholipids. May play a role in adipocyte lipolysis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2VCW1;Q62679", "ec_number_list": "3.1.1.1;3.1.1.88;3.1.1.-;3.1.1.28;3.1.1.23;3.1.1.79;3.1.1.67;3.1.1.3", "go_molecular_function": "GO:0050253 retinyl-palmitate esterase activity;GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0036116 long-chain fatty-acyl-CoA catabolic process;GO:0019626 short-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q64573-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64602-1", "uniprot_id": "AADAT_RAT", "mass": 47784.0, "length": 425, "protein_name": "Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial", "gene_name": "Aadat", "organism": "Rat", "refseq_name": "kynurenine/alpha-aminoadipate aminotransferase, mitochondrial", "refseq_ac": "NP_058889", "gene_names_uniprotkb": "Aadat; Kat2", "gene_names_refseq": "Aadat; Kat2", "protein_names_uniprotkb": "Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; 2.6.1.39; 2.6.1.4; 2.6.1.63; 2.6.1.73; 2.6.1.7; AadAT; Alpha-aminoadipate aminotransferase; Glycine transaminase AADAT; KAT/AadAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT", "protein_names_refseq": "2-aminoadipate aminotransferase; 2-aminoadipate transaminase; KAT/AadAT; alpha-aminoadipate aminotransferase; glycine transaminase AADAT; kynurenine aminotransferase 2; kynurenine aminotransferase II; kynurenine--glyoxylate transaminase AADAT; kynurenine--oxoglutarate aminotransferase II; kynurenine--oxoglutarate transaminase 2; kynurenine--oxoglutarate transaminase II; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; methionine--glyoxylate transaminase AADAT", "tax_id": 10116, "disease": "spermatogenic failure 45 (Disease Ontology:DOID:0112163)", "pathway": " (rno:29416); (R-RNO-71064); (R-RNO-71240)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;7493966", "class_list": "", "function": "Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.6.1.7;2.6.1.1;2.6.1.64;4.4.1.13;2.6.1.63;2.6.1.39;2.6.1.4;2.6.1.73", "go_molecular_function": "GO:0047315 kynurenine-glyoxylate transaminase activity;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0047536 2-aminoadipate transaminase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006536 glutamate metabolic process;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0070189 kynurenine metabolic process;GO:1901605 alpha-amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64602-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H03-1", "uniprot_id": "ERIC2_RAT", "mass": 47182.0, "length": 433, "protein_name": "Glutamate-rich protein 2", "gene_name": "Erich2", "organism": "Rat", "refseq_name": "glutamate-rich protein 2", "refseq_ac": "NP_001019482", "gene_names_uniprotkb": "Erich2", "gene_names_refseq": "Erich2", "protein_names_uniprotkb": "Glutamate-rich protein 2", "protein_names_refseq": "glutamate-rich protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:499806)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H04-1", "uniprot_id": "FBX43_RAT", "mass": 73228.0, "length": 664, "protein_name": "F-box only protein 43", "gene_name": "Fbxo43", "organism": "Rat", "refseq_name": "F-box only protein 43", "refseq_ac": "NP_001012117", "gene_names_uniprotkb": "Fbxo43; Emi2", "gene_names_refseq": "Fbxo43", "protein_names_uniprotkb": "F-box only protein 43; Endogenous meiotic inhibitor 2", "protein_names_refseq": "F-box only protein 43; endogenous meiotic inhibitor 2", "tax_id": 10116, "disease": "spermatogenic failure 64 (Disease Ontology:DOID:0112353)", "pathway": " (rno:315034)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (By similarity). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0010948 negative regulation of cell cycle process;GO:1990090 cellular response to nerve growth factor stimulus;GO:0016567 protein ubiquitination;GO:0042177 negative regulation of protein catabolic process;GO:0007088 regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H10-1", "uniprot_id": "FBX39_RAT", "mass": 52504.0, "length": 443, "protein_name": "F-box only protein 39", "gene_name": "Fbxo39", "organism": "Rat", "refseq_name": "F-box only protein 39", "refseq_ac": "NP_001034107", "gene_names_uniprotkb": "Fbxo39", "gene_names_refseq": "Fbxo39", "protein_names_uniprotkb": "F-box only protein 39", "protein_names_refseq": "F-box only protein 39", "tax_id": 10116, "disease": "", "pathway": " (rno:303287)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q498T6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H39-1", "uniprot_id": "ABCF3_RAT", "mass": 79856.0, "length": 709, "protein_name": "ATP-binding cassette sub-family F member 3", "gene_name": "Abcf3", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family F member 3", "refseq_ac": "NP_001011896", "gene_names_uniprotkb": "Abcf3", "gene_names_refseq": "Abcf3", "protein_names_uniprotkb": "ATP-binding cassette sub-family F member 3", "protein_names_refseq": "ATP-binding cassette sub-family F member 3; ATP-binding cassette, sub-family F (GCN20), member 3; ATP-binding cassette, subfamily F (GCN20), member 3", "tax_id": 10116, "disease": "", "pathway": " (rno:287982)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "", "go_biological_process": "GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H69-1", "uniprot_id": "B3GN7_RAT", "mass": 45447.0, "length": 397, "protein_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7", "gene_name": "B3gnt7", "organism": "Rat", "refseq_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7", "refseq_ac": "NP_001012134", "gene_names_uniprotkb": "B3gnt7", "gene_names_refseq": "B3gnt7", "protein_names_uniprotkb": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7; 2.4.1.-; BGnT-7; Beta-1,3-Gn-T7; Beta-1,3-N-acetylglucosaminyltransferase 7; Beta3Gn-T7", "protein_names_refseq": "BGnT-7; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7; beta-1,3-Gn-T7; beta-1,3-N-acetylglucosaminyltransferase 7; beta3Gn-T7", "tax_id": 10116, "disease": "", "pathway": " (rno:316583); (R-RNO-2022854); (R-RNO-913709)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N-and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (By similarity). Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency (By similarity). May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.206", "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0018146 keratan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66H71-1", "uniprot_id": "CPPED_RAT", "mass": 35261.0, "length": 312, "protein_name": "Serine/threonine-protein phosphatase CPPED1", "gene_name": "Cpped1", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase CPPED1", "refseq_ac": "NP_001013985", "gene_names_uniprotkb": "Cpped1; Cstp1", "gene_names_refseq": "Cpped1; RGD1306568", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase CPPED1; 3.1.3.16; Calcineurin-like phosphoesterase domain-containing protein 1", "protein_names_refseq": "calcineurin-like phosphoesterase domain-containing protein 1; serine/threonine-protein phosphatase CPPED1", "tax_id": 10116, "disease": "", "pathway": " (rno:302890); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;1.11.2.2;3.4.21.4;3.4.16.-;3.1.3.48;3.1.3.53;3.2.1.-;5.3.4.1;3.1.3.52;1.1.1.205;3.2.1.23;5.3.99.3;1.11.1.27;3.1.1.4;2.3.1.23;3.1.3.67;3.1.3.-;3.2.1.17;3.2.1.31;3.5.3.1;2.7.11.13;3.1.3.27;2.3.3.8;3.2.1.51;3.4.21.20;1.6.2.2;3.5.3.15;3.5.1.26;3.6.4.6;3.1.6.12;2.4.1.1;2.7.11.24;2.7.11.22;3.1.27.-;3.4.14.1;3.1.6.4;3.1.6.8;1.6.5.5;3.6.1.-;2.7.10.2;3.4.19.9;3.2.1.52;6.3.4.21;3.1.3.74;3.4.14.2", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66H71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66HA2-1", "uniprot_id": "CR3L1_RAT", "mass": 57134.0, "length": 520, "protein_name": "Cyclic AMP-responsive element-binding protein 3-like protein 1", "gene_name": "Creb3l1", "organism": "Rat", "refseq_name": "cyclic AMP-responsive element-binding protein 3-like protein 1", "refseq_ac": "NP_001005562", "gene_names_uniprotkb": "Creb3l1; Oasis", "gene_names_refseq": "Creb3l1; Oasis", "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 3-like protein 1; OASIS; Old astrocyte specifically-induced substance; cAMP-responsive element-binding protein 3-like protein 1", "protein_names_refseq": "cAMP-responsive element-binding protein 3-like protein 1; cyclic AMP-responsive element-binding protein 3-like protein 1; old astrocyte specifically-induced substance", "tax_id": 10116, "disease": "osteogenesis imperfecta type 16 (Disease Ontology:DOID:0110345)", "pathway": " (rno:362165)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20668028;26503226;32319174;35051932;35455992", "class_list": "", "function": "Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition., [UniProtKB, UniProtKB]; Results suggest that the repertoire of genes induced by OASIS is cell type-dependent and that the OASIS protein may have a role in pancreas development., [RefSeq, PubMed]; This data provides the connection between CREB3L1, a newly identified transcription factor of AVP expression. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription Factor CREB3L1 Regulates the Expression of the Sodium/Iodide Symporter (NIS) in Rat Thyroid Follicular Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor Creb3l1 regulates the synthesis of prohormone convertase enzyme PC1/3 in endocrine cells., [RefSeq, PubMed]; Transcription factor involved in cell type specific DNA damage and unfolded protein response (UPR) (By similarity). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation. In astrocytes and osteoblasts, upon DNA damage, inhibits cell-cycle progression after G2/M phase by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046332 SMAD binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q66HA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66HC3-1", "uniprot_id": "CI072_RAT", "mass": 54306.0, "length": 481, "protein_name": "Guanine nucleotide exchange factor C9orf72 homolog", "gene_name": "C9orf72; RGD1359108", "organism": "Rat", "refseq_name": "guanine nucleotide exchange factor C9orf72 homolog", "refseq_ac": "NP_001007703", "gene_names_uniprotkb": "C9orf72; RGD1359108; Dennd9; Dennl72", "gene_names_refseq": "C9orf72; RGD1359108", "protein_names_uniprotkb": "Guanine nucleotide exchange factor C9orf72 homolog", "protein_names_refseq": "guanine nucleotide exchange C9orf72 homolog; guanine nucleotide exchange factor C9orf72 homolog; protein C9orf72 homolog; uncharacterized protein C9orf72 homolog", "tax_id": 10116, "disease": "C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis (Disease Ontology:DOID:0060213); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); autoimmune disease (Disease Ontology:DOID:417)", "pathway": " (rno:313155)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "29398115;32745320;35451425;36438488", "class_list": "", "function": "Ablation of C9orf72 together with excitotoxicity induces ALS in rats., [RefSeq, PubMed]; Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy. Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy. As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro. The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and modulating its protein kinase activity (By similarity). Promotes initiation of autophagy by regulating the RAB1A-dependent trafficking of the ULK1/ATG1 kinase complex to the phagophore which leads to autophagosome formation. Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates. Plays a role in endosomal trafficking (By similarity). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Promotes the lysosomal localization and lysosome-mediated degradation of CARM1 which leads to inhibition of starvation-induced lipid metabolism (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation. This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to CFL1/cofilin activation. Positively regulates axon extension and axon growth cone size in spinal motor neurons (By similarity). Required for SMCR8 protein expression and localization at pre- and post-synaptic compartments in the forebrain, also regulates protein abundance of RAB3A and GRIA1/GLUR1 in post-synaptic compartments in the forebrain and hippocampus (By similarity). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2alpha. Publication Status: Online-Only, [RefSeq, PubMed]; In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment., [RefSeq, PubMed]; Overexpression of C9orf72 exacerbates Abeta2535induced oxidative stress and apoptosis in PC12 cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0006897 endocytosis;GO:0010506 regulation of autophagy;GO:0001933 negative regulation of protein phosphorylation;GO:0032880 regulation of protein localization;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66HC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66HH1-1", "uniprot_id": "B4GT4_RAT", "mass": 39707.0, "length": 344, "protein_name": "Beta-1,4-galactosyltransferase 4", "gene_name": "B4galt4", "organism": "Rat", "refseq_name": "beta-1,4-galactosyltransferase 4", "refseq_ac": "NP_001012018", "gene_names_uniprotkb": "B4galt4", "gene_names_refseq": "B4galt4", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 4; 2.4.1.-; 2.4.1.275; 2.4.1.90; Beta-1,4-GalTase 4; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta4Gal-T4; Lactotriaosylceramide beta-1,4-galactosyltransferase; N-acetyllactosamine synthase; Nal synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4; b4Gal-T4", "protein_names_refseq": "N-acetyllactosamine synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4; b4Gal-T4; beta-1,4-GalTase 4; beta-1,4-galactosyltransferase 4; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; beta4Gal-T4; lactotriaosylceramide beta-1,4-galactosyltransferase; nal synthase", "tax_id": 10116, "disease": "", "pathway": " (rno:303923); (R-RNO-2022854); (R-RNO-975577)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids. Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans. Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono-and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex). May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration. In the biosynthesis pathway of neolacto-series glycosphingolipids, transfers Gal residue via a beta1->4 linkage to terminal GlcNAc of a lactotriaosylceramide (Lc3Cer) acceptor to form a neolactotetraosylceramide. Efficiently galactosylates both non-sulfated and 6-O-sulfated terminal GlcNAc moities on G0 complex-type N-glycans., [UniProtKB, UniProtKB]; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.274;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90", "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945 N-acetyllactosamine synthase activity;GO:0035250 UDP-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0018146 keratan sulfate proteoglycan biosynthetic process;GO:0001572 lactosylceramide biosynthetic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 2205, "hit_score": 0.1, "record_id": "Q66HH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FN9-1", "uniprot_id": "FAKD3_RAT", "mass": 75248.0, "length": 656, "protein_name": "FAST kinase domain-containing protein 3, mitochondrial", "gene_name": "Fastkd3", "organism": "Rat", "refseq_name": "FAST kinase domain-containing protein 3, mitochondrial precursor", "refseq_ac": "NP_001076043", "gene_names_uniprotkb": "Fastkd3", "gene_names_refseq": "Fastkd3; RGD1309729", "protein_names_uniprotkb": "FAST kinase domain-containing protein 3, mitochondrial", "protein_names_refseq": "FAST kinase domain-containing protein 3, mitochondrial precursor; FAST kinase domain-containing protein 3, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:290946)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0000963 mitochondrial RNA processing;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0070131 positive regulation of mitochondrial translation;GO:0044528 regulation of mitochondrial mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FP9-1", "uniprot_id": "COG6_RAT", "mass": 72957.0, "length": 657, "protein_name": "Conserved oligomeric Golgi complex subunit 6", "gene_name": "Cog6", "organism": "Rat", "refseq_name": "conserved oligomeric Golgi complex subunit 6", "refseq_ac": "NP_001004262", "gene_names_uniprotkb": "Cog6", "gene_names_refseq": "Cog6", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 6; COG complex subunit 6; Component of oligomeric Golgi complex 6", "protein_names_refseq": "COG complex subunit 6; conserved oligomeric Golgi complex subunit 6", "tax_id": 10116, "disease": "congenital disorder of glycosylation type IIl (Disease Ontology:DOID:0070264)", "pathway": " (rno:310411); (R-RNO-6807878); (R-RNO-6811438); (R-RNO-6811440)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for normal Golgi function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0015031 protein transport;GO:0007030 Golgi organization;GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FS2-1", "uniprot_id": "CSN4_RAT", "mass": 46290.0, "length": 406, "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "Cops4", "organism": "Rat", "refseq_name": "COP9 signalosome complex subunit 4", "refseq_ac": "NP_001004275", "gene_names_uniprotkb": "Cops4; Csn4", "gene_names_refseq": "Cops4", "protein_names_uniprotkb": "COP9 signalosome complex subunit 4; JAB1-containing signalosome subunit 4; SGN4; Signalosome subunit 4", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 4; COP9 signalosome complex subunit 4; JAB1-containing signalosome subunit 4; SGN4; signalosome subunit 4", "tax_id": 10116, "disease": "", "pathway": " (rno:360915); (R-RNO-5696394); (R-RNO-6781823); (R-RNO-8856825); (R-RNO-8951664); (R-RNO-9013422)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "21102408", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0008021 synaptic vesicle;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FU3-1", "uniprot_id": "ETFB_RAT", "mass": 27687.0, "length": 255, "protein_name": "Electron transfer flavoprotein subunit beta", "gene_name": "Etfb", "organism": "Rat", "refseq_name": "electron transfer flavoprotein subunit beta", "refseq_ac": "NP_001004220", "gene_names_uniprotkb": "Etfb", "gene_names_refseq": "Etfb", "protein_names_uniprotkb": "Electron transfer flavoprotein subunit beta; Beta-ETF", "protein_names_refseq": "beta-ETF; electron transfer flavoprotein beta subunit; electron transfer flavoprotein subunit beta; electron transferring flavoprotein, beta polypeptide; electron-transfer-flavoprotein, beta polypeptide", "tax_id": 10116, "disease": "multiple acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0060358)", "pathway": " (rno:292845); (R-RNO-611105); (R-RNO-8876725)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "26446791;27035869;27213235;34502162;7334008", "class_list": "", "function": "Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:7334008). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)., [UniProtKB, UniProtKB]; The findings of our present study suggest that ETFbeta plays an important role in renal tubular cell apoptosis during the progression of DN., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045251 electron transfer flavoprotein complex", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0022904 respiratory electron transport chain;GO:0009063 amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q68FU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FU7-1", "uniprot_id": "COQ6_RAT", "mass": 51496.0, "length": 476, "protein_name": "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial", "gene_name": "Coq6", "organism": "Rat", "refseq_name": "ubiquinone biosynthesis monooxygenase COQ6, mitochondrial precursor", "refseq_ac": "NP_001011983", "gene_names_uniprotkb": "Coq6", "gene_names_refseq": "Coq6", "protein_names_uniprotkb": "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; 1.14.15.45; 1.14.15.46; 2-methoxy-6-polyprenolphenol 4-hydroxylase; Coenzyme Q10 monooxygenase 6", "protein_names_refseq": "2-methoxy-6-polyprenolphenol 4-hydroxylase; coenzyme Q10 monooxygenase 6; coenzyme Q6 homolog, monooxygenase; ubiquinone biosynthesis monooxygenase COQ6, mitochondrial precursor; ubiquinone biosynthesis monooxygenase COQ6, mitochondrial", "tax_id": 10116, "disease": "primary coenzyme Q10 deficiency 6 (Disease Ontology:DOID:0070243); nephrotic syndrome (Disease Ontology:DOID:1184); schwannomatosis (Disease Ontology:DOID:3204)", "pathway": " (rno:299195); (R-RNO-2142789)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21540551", "class_list": "", "function": "FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-decaprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid. Also acts downstream of COQ4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-decaprenyl)phenol to 2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to COQ6 from NADPH via a ferredoxin/ferredoxin reductase system composed of FDX2 and FDXR., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.130;2.1.1.201;2.7.-.-;2.1.1.-;2.1.1.114;2.1.1.64;1.14.13.253;1.14.15.45;1.14.15.46", "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0106364 4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005794 Golgi apparatus;GO:0042995 cell projection", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FV2-1", "uniprot_id": "AR6P6_RAT", "mass": 24596.0, "length": 223, "protein_name": "ADP-ribosylation factor-like protein 6-interacting protein 6", "gene_name": "Arl6ip6", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-like protein 6-interacting protein 6", "refseq_ac": "NP_001019481", "gene_names_uniprotkb": "Arl6ip6", "gene_names_refseq": "Arl6ip6", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 6-interacting protein 6; ARL-6-interacting protein 6; Aip-6", "protein_names_refseq": "ADP ribosylation factor like GTPase 6 interacting protein 6; ADP-ribosylation factor GTPase 6 interacting protein 6; ADP-ribosylation factor-like 6 interacting protein 6; ADP-ribosylation factor-like protein 6-interacting protein 6; ADP-ribosylation-like factor 6-interacting protein 6; ARL-6-interacting protein 6; aip-6", "tax_id": 10116, "disease": "", "pathway": " (rno:499798)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005637 nuclear inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FV3-1", "uniprot_id": "OFUT4_RAT", "mass": 56000.0, "length": 494, "protein_name": "GDP-fucose protein O-fucosyltransferase 4", "gene_name": "Pofut4", "organism": "Rat", "refseq_name": "GDP-fucose protein O-fucosyltransferase 4 precursor", "refseq_ac": "NP_775430", "gene_names_uniprotkb": "Pofut4; Fut11", "gene_names_refseq": "Fut11; Pofut4", "protein_names_uniprotkb": "GDP-fucose protein O-fucosyltransferase 4; 2.4.1.-; 2.4.1.221; Alpha-(1,3)-fucosyltransferase 11; Fuc-TXI; FucT-XI; Fucosyltransferase 11; Fucosyltransferase XI; Galactoside 3-L-fucosyltransferase 11", "protein_names_refseq": "GDP-fucose protein O-fucosyltransferase 4 precursor; GDP-fucose protein O-fucosyltransferase 4; alpha-(1,3)-fucosyltransferase 11; alpha3-fucosyltransferase 11; fuc-TXI; fucT-XI; fucosyltransferase 11 (alpha (1,3) fucosyltransferase); fucosyltransferase XI; galactoside 3-L-fucosyltransferase 11", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (rno:286971); (R-RNO-5173105)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion. Also shows minor alpha-(1,3)-fucosyltransferase activity toward activity toward biantennary N-glycan acceptors. However, this was tested with a library of synthetic substrates and this activity is unsure in vivo., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CG40", "ec_number_list": "2.4.1.221;2.4.1.-", "go_molecular_function": "GO:0046922 peptide-O-fucosyltransferase activity;GO:0008417 fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050714 positive regulation of protein secretion;GO:0006491 N-glycan processing", "synthesized_glycan_count": 1641, "hit_score": 0.1, "record_id": "Q68FV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FW9-1", "uniprot_id": "CSN3_RAT", "mass": 47859.0, "length": 423, "protein_name": "COP9 signalosome complex subunit 3", "gene_name": "Cops3", "organism": "Rat", "refseq_name": "COP9 signalosome complex subunit 3", "refseq_ac": "NP_001004200", "gene_names_uniprotkb": "Cops3; Csn3", "gene_names_refseq": "Cops3", "protein_names_uniprotkb": "COP9 signalosome complex subunit 3; SGN3; Signalosome subunit 3", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 3; COP9 signalosome complex subunit 3; SGN3; signalosome subunit 3", "tax_id": 10116, "disease": "", "pathway": " (rno:287367); (R-RNO-5696394); (R-RNO-6781823); (R-RNO-8856825); (R-RNO-8951664)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0001701 in utero embryonic development;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXP3-1", "uniprot_id": "F227B_RAT", "mass": 67304.0, "length": 573, "protein_name": "Protein FAM227B", "gene_name": "Fam227b", "organism": "Rat", "refseq_name": "protein FAM227B", "refseq_ac": "NP_001013942", "gene_names_uniprotkb": "Fam227b", "gene_names_refseq": "Fam227b; RGD1359452", "protein_names_uniprotkb": "Protein FAM227B", "protein_names_refseq": "protein FAM227B; uncharacterized protein C15orf33 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:296118)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVN5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXQ2-1", "uniprot_id": "EFC11_RAT", "mass": 18494.0, "length": 162, "protein_name": "EF-hand calcium-binding domain-containing protein 11", "gene_name": "Efcab11", "organism": "Rat", "refseq_name": "EF-hand calcium-binding domain-containing protein 11", "refseq_ac": "NP_001019521", "gene_names_uniprotkb": "Efcab11", "gene_names_refseq": "Efcab11", "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 11", "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 11; EF-hand domain-containing protein C14orf143 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500705)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXU1-1", "uniprot_id": "BTBDG_RAT", "mass": 58458.0, "length": 506, "protein_name": "BTB/POZ domain-containing protein 16", "gene_name": "Btbd16", "organism": "Rat", "refseq_name": "BTB/POZ domain-containing protein 16", "refseq_ac": "NP_001017464", "gene_names_uniprotkb": "Btbd16", "gene_names_refseq": "Btbd16; RGD1311454", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 16", "protein_names_refseq": "BTB (POZ) domain containing 16; BTB/POZ domain-containing protein 16", "tax_id": 10116, "disease": "", "pathway": " (rno:361658)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXV7-1", "uniprot_id": "F187A_RAT", "mass": 47804.0, "length": 418, "protein_name": "Ig-like V-type domain-containing protein FAM187A", "gene_name": "Fam187a", "organism": "Rat", "refseq_name": "Ig-like V-type domain-containing protein FAM187A precursor", "refseq_ac": "NP_001013883", "gene_names_uniprotkb": "Fam187a", "gene_names_refseq": "Fam187a; RGD1307851", "protein_names_uniprotkb": "Ig-like V-type domain-containing protein FAM187A", "protein_names_refseq": "Ig-like V-type domain-containing protein FAM187A precursor; ig-like V-type domain-containing protein ENSP00000329499 homolog; ig-like V-type domain-containing protein FAM187A", "tax_id": 10116, "disease": "", "pathway": " (rno:287741)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AXX9-1", "uniprot_id": "ABEC4_RAT", "mass": 44519.0, "length": 388, "protein_name": "Putative deaminase APOBEC-4", "gene_name": "Apobec4", "organism": "Rat", "refseq_name": "putative deaminase APOBEC-4", "refseq_ac": "NP_001017492", "gene_names_uniprotkb": "Apobec4", "gene_names_refseq": "Apobec4", "protein_names_uniprotkb": "Putative deaminase APOBEC-4; 3.5.4.-; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4", "protein_names_refseq": "apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative); putative C->U-editing enzyme APOBEC-4; putative deaminase APOBEC-4", "tax_id": 10116, "disease": "", "pathway": " (rno:498251); (R-RNO-72200); (R-RNO-75094)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative deaminase whose physiological substrate is not yet known., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.4.-;3.5.4.36;3.5.4.38", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY08-1", "uniprot_id": "FACC1_RAT", "mass": 48491.0, "length": 411, "protein_name": "Flagellum-associated coiled-coil domain-containing protein 1", "gene_name": "Flacc1", "organism": "Rat", "refseq_name": "flagellum-associated coiled-coil domain-containing protein 1 isoform 2", "refseq_ac": "NP_001014123", "gene_names_uniprotkb": "Flacc1; Als2cr12", "gene_names_refseq": "Als2cr12; Flacc1", "protein_names_uniprotkb": "Flagellum-associated coiled-coil domain-containing protein 1; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog", "protein_names_refseq": "amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog; amyotrophic lateral sclerosis 2 chromosome region 12; amyotrophic lateral sclerosis 2 chromosome region, candidate 12; flagellum-associated coiled-coil domain-containing protein 1 isoform 2; flagellum-associated coiled-coil domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:316413)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0036126 sperm flagellum;GO:0035686 sperm fibrous sheath", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY17-1", "uniprot_id": "AB17B_RAT", "mass": 32201.0, "length": 288, "protein_name": "Alpha/beta hydrolase domain-containing protein 17B", "gene_name": "Abhd17b", "organism": "Rat", "refseq_name": "alpha/beta hydrolase domain-containing protein 17B", "refseq_ac": "NP_001014050", "gene_names_uniprotkb": "Abhd17b", "gene_names_refseq": "Abhd17b; Cgi67l; Fam108b1; RGD1305246", "protein_names_uniprotkb": "Alpha/beta hydrolase domain-containing protein 17B; 3.1.2.22; Abhydrolase domain-containing protein 17B", "protein_names_refseq": "abhydrolase domain-containing protein 17B; abhydrolase domain-containing protein FAM108B1; alpha/beta hydrolase domain-containing protein 17B; family with sequence similarity 108, member B1; protein ABHD17B", "tax_id": 10116, "disease": "", "pathway": " (rno:309399); (R-RNO-9648002)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;27307232", "class_list": "", "function": "Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Has depalmitoylating activity towards GAP43. Has depalmitoylating activity towards MAP6. Has depalmitoylating activity towards NRAS., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.22;2.3.1.21;3.6.5.2;3.1.2.2;3.1.2.-;3.4.-.-;3.1.1.93;3.4.19.12", "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:1905668 positive regulation of protein localization to endosome;GO:1902473 regulation of protein localization to synapse;GO:1902950 regulation of dendritic spine maintenance;GO:0002084 protein depalmitoylation;GO:0099175 regulation of postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AY17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY27-1", "uniprot_id": "FBX17_RAT", "mass": 28234.0, "length": 250, "protein_name": "F-box only protein 17", "gene_name": "Fbxo17", "organism": "Rat", "refseq_name": "F-box only protein 17", "refseq_ac": "NP_001013082", "gene_names_uniprotkb": "Fbxo17", "gene_names_refseq": "Fbg4; Fbx17; Fbxo17; Fbxo26", "protein_names_uniprotkb": "F-box only protein 17", "protein_names_refseq": "F-box only protein 17", "tax_id": 10116, "disease": "", "pathway": " (rno:292757); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0036503 ERAD pathway;GO:0006516 glycoprotein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY71-1", "uniprot_id": "CF418_RAT", "mass": 23771.0, "length": 210, "protein_name": "Cilia- and flagella-associated protein 418", "gene_name": "Cfap418", "organism": "Rat", "refseq_name": "cilia- and flagella-associated protein 418 isoform 1", "refseq_ac": "NP_001007747", "gene_names_uniprotkb": "Cfap418", "gene_names_refseq": "Cfap418", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 418", "protein_names_refseq": "cilia- and flagella-associated protein 418 isoform 1; uncharacterized protein C8orf37 homolog", "tax_id": 10116, "disease": "Bardet-Biedl syndrome 21 (Disease Ontology:DOID:0081010); cone-rod dystrophy 16 (Disease Ontology:DOID:0111022); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:362483)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in photoreceptor outer segment disk morphogenesis (By similarity)., [UniProtKB, UniProtKB]; May be involved in photoreceptor outer segment disk morphogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment;GO:0097546 ciliary base", "go_biological_process": "GO:0008594 photoreceptor cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY72-1", "uniprot_id": "CS025_RAT", "mass": 12143.0, "length": 109, "protein_name": "UPF0449 protein C19orf25 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "UPF0449 protein C19orf25 homolog", "refseq_ac": "NP_001007658", "gene_names_uniprotkb": "", "gene_names_refseq": "C7h19orf25; RGD1359127", "protein_names_uniprotkb": "UPF0449 protein C19orf25 homolog", "protein_names_refseq": "UPF0449 protein C19orf25 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:299612)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AY85-1", "uniprot_id": "ALG14_RAT", "mass": 23979.0, "length": 216, "protein_name": "UDP-N-acetylglucosamine transferase subunit ALG14", "gene_name": "Alg14", "organism": "Rat", "refseq_name": "UDP-N-acetylglucosamine transferase subunit ALG14", "refseq_ac": "NP_001014198", "gene_names_uniprotkb": "Alg14", "gene_names_refseq": "Alg14; RGD1312003", "protein_names_uniprotkb": "UDP-N-acetylglucosamine transferase subunit ALG14; Asparagine-linked glycosylation 14 homolog", "protein_names_refseq": "UDP-N-acetylglucosamine transferase subunit ALG14 homolog; UDP-N-acetylglucosamine transferase subunit ALG14; asparagine-linked glycosylation 14 homolog", "tax_id": 10116, "disease": "congenital myasthenic syndrome 15 (Disease Ontology:DOID:0110658)", "pathway": " (rno:362031); (R-RNO-446193)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharides are transferred from the lipid to nascent proteins by oligosaccharyltransferases. Functions as a protein-membrane adapter recruiting ALG13 at the cytoplasmic face of the endoplasmic reticulum, where the complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0043541 UDP-N-acetylglucosamine transferase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 15150, "hit_score": 0.1, "record_id": "Q6AY85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYD4-1", "uniprot_id": "ESAM_RAT", "mass": 41936.0, "length": 394, "protein_name": "Endothelial cell-selective adhesion molecule", "gene_name": "Esam", "organism": "Rat", "refseq_name": "endothelial cell-selective adhesion molecule precursor", "refseq_ac": "NP_001004245", "gene_names_uniprotkb": "Esam", "gene_names_refseq": "Esam", "protein_names_uniprotkb": "Endothelial cell-selective adhesion molecule", "protein_names_refseq": "endothelial cell-selective adhesion molecule precursor; endothelial cell-selective adhesion molecule", "tax_id": 10116, "disease": "", "pathway": " (rno:300519); (R-RNO-202733)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Can mediate aggregation most likely through a homophilic molecular interaction., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0032991 protein-containing complex", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0008104 intracellular protein localization;GO:0070830 bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYG5-1", "uniprot_id": "ECHD1_RAT", "mass": 32631.0, "length": 299, "protein_name": "Ethylmalonyl-CoA decarboxylase", "gene_name": "Echdc1", "organism": "Rat", "refseq_name": "ethylmalonyl-CoA decarboxylase isoform 1", "refseq_ac": "NP_001007735", "gene_names_uniprotkb": "Echdc1", "gene_names_refseq": "Echdc1; MMCD", "protein_names_uniprotkb": "Ethylmalonyl-CoA decarboxylase; 4.1.1.94; Enoyl-CoA hydratase domain-containing protein 1; MMCD; Methylmalonyl-CoA decarboxylase", "protein_names_refseq": "enoyl CoA hydratase domain containing 1; enoyl Coenzyme A hydratase domain containing 1; enoyl-CoA hydratase domain-containing protein 1; ethylmalonyl-CoA decarboxylase isoform 1; methylmalonyl-CoA decarboxylase", "tax_id": 10116, "disease": "", "pathway": " (rno:361465)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22016388", "class_list": "", "function": "Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.94", "go_molecular_function": "GO:0004492 methyl/ethyl malonyl-CoA decarboxylase activity;GO:0016831 carboxy-lyase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYJ5-1", "uniprot_id": "CLUA1_RAT", "mass": 46572.0, "length": 402, "protein_name": "Clusterin-associated protein 1", "gene_name": "Cluap1", "organism": "Rat", "refseq_name": "clusterin-associated protein 1 isoform 4", "refseq_ac": "NP_001014247", "gene_names_uniprotkb": "Cluap1", "gene_names_refseq": "Cluap1; Ift38", "protein_names_uniprotkb": "Clusterin-associated protein 1", "protein_names_refseq": "clusterin associated protein 1; clusterin-associated protein 1 isoform 4", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-5620924)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0005815 microtubule organizing center;GO:0097546 ciliary base", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0021508 floor plate formation;GO:0001843 neural tube closure;GO:0060271 cilium assembly;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYK8-1", "uniprot_id": "EIF3D_RAT", "mass": 63989.0, "length": 548, "protein_name": "Eukaryotic translation initiation factor 3 subunit D", "gene_name": "Eif3d", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 3 subunit D", "refseq_ac": "NP_001004283", "gene_names_uniprotkb": "Eif3d; EIF3D; EIF3S7; Eif3s7", "gene_names_refseq": "Eif3d; Eif3s7", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit D; Eukaryotic translation initiation factor 3 subunit 7; eIF-3-zeta; eIF3d", "protein_names_refseq": "eIF-3-zeta; eukaryotic translation initiation factor 3 subunit 7; eukaryotic translation initiation factor 3 subunit D; eukaryotic translation initiation factor 3, subunit 7 (zeta)", "tax_id": 10116, "disease": "", "pathway": " (rno:362952); (R-RNO-156827); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0098808 mRNA cap binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation;GO:0002191 cap-dependent translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYM4-1", "uniprot_id": "DPCD_RAT", "mass": 23155.0, "length": 203, "protein_name": "Protein DPCD", "gene_name": "Dpcd", "organism": "Rat", "refseq_name": "protein DPCD isoform 2", "refseq_ac": "NP_001013927", "gene_names_uniprotkb": "Dpcd", "gene_names_refseq": "Dpcd; RGD1307648", "protein_names_uniprotkb": "Protein DPCD", "protein_names_refseq": "protein DPCD isoform 2; protein DPCD", "tax_id": 10116, "disease": "hydrocephalus (Disease Ontology:DOID:10908); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:294004)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in the formation or function of ciliated cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYP0-1", "uniprot_id": "ALLC_RAT", "mass": 46037.0, "length": 413, "protein_name": "Probable inactive allantoicase", "gene_name": "Allc", "organism": "Rat", "refseq_name": "probable inactive allantoicase", "refseq_ac": "NP_001013055", "gene_names_uniprotkb": "Allc", "gene_names_refseq": "Allc", "protein_names_uniprotkb": "Probable inactive allantoicase; Allantoate amidinohydrolase", "protein_names_refseq": "allantoate amidinohydrolase; probable allantoicase; probable inactive allantoicase", "tax_id": 10116, "disease": "", "pathway": " (rno:246758)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14745534", "class_list": "", "function": "The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K470", "ec_number_list": "", "go_molecular_function": "GO:0004037 allantoicase activity", "go_cellular_component": "", "go_biological_process": "GO:0051592 response to calcium ion;GO:0009268 response to pH;GO:0000256 allantoin catabolic process;GO:0032026 response to magnesium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6AYR5-1", "uniprot_id": "CLRN3_RAT", "mass": 25278.0, "length": 226, "protein_name": "Clarin-3", "gene_name": "Clrn3", "organism": "Rat", "refseq_name": "clarin-3", "refseq_ac": "NP_001014048", "gene_names_uniprotkb": "Clrn3; Tmem12", "gene_names_refseq": "Clrn3; RGD1305043; Tmem12", "protein_names_uniprotkb": "Clarin-3; Transmembrane protein 12", "protein_names_refseq": "clarin-3; transmembrane protein 12", "tax_id": 10116, "disease": "", "pathway": " (rno:309082)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYR5-1", "record_type": "protein" } ]