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Complex I functions in the transfer of electrons from NADH to the respiratory chain. 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Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Also modulates STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Knockdown of Tripartite Motif 8 Protects H9C2 Cells Against Hypoxia/Reoxygenation-Induced Injury Through the Activation of PI3K/Akt Signaling Pathway., [RefSeq, PubMed]; Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016605 PML body", "go_biological_process": "GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:0032897 negative regulation of viral transcription;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZQE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZQF7-1", "uniprot_id": "D3ZQF7_RAT", "mass": 40228.0, "length": 352, "protein_name": "Putative P2Y purinoceptor 10", "gene_name": "P2ry10b", "organism": "Rat", "refseq_name": "P2Y receptor family member 10B", "refseq_ac": "NP_001100409", "gene_names_uniprotkb": "P2ry10b", "gene_names_refseq": "P2ry10b; RGD1560455", "protein_names_uniprotkb": "Putative P2Y purinoceptor 10", "protein_names_refseq": "P2Y receptor family member 10B; Putative P2Y purinoceptor 10-like; purinergic receptor P2Y, G-protein coupled 10B", "tax_id": 10116, "disease": "", "pathway": " (rno:302377)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative receptor for purines coupled to G-proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZQJ2-1", "uniprot_id": "D3ZQJ2_RAT", "mass": 15745.0, "length": 140, "protein_name": "Ribonuclease P protein subunit p20", "gene_name": "Pop7", "organism": "Rat", "refseq_name": "ribonuclease P protein subunit p20", "refseq_ac": "NP_001099388", "gene_names_uniprotkb": "Pop7", "gene_names_refseq": "Pop7; Rpp20", "protein_names_uniprotkb": "Ribonuclease P protein subunit p20; RNaseP protein p20", "protein_names_refseq": "POP7 homolog, ribonuclease P/MRP subunit; processing of precursor 7, ribonuclease P/MRP subunit; ribonuclease P protein subunit p20", "tax_id": 10116, "disease": "", "pathway": " (rno:288564)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZQN3-1", "uniprot_id": "D3ZQN3_RAT", "mass": 72389.0, "length": 667, "protein_name": "PNMA family member 8B", "gene_name": "Pnma8b", "organism": "Rat", "refseq_name": "paraneoplastic antigen-like protein 8B", "refseq_ac": "NP_001100951", "gene_names_uniprotkb": "Pnma8b; Pnmal2", "gene_names_refseq": "Pnma8b; Pnmal2; RGD1560435", "protein_names_uniprotkb": "PNMA family member 8B", "protein_names_refseq": "PNMA-like 2; PNMA-like protein 2; paraneoplastic Ma antigen family member 8B; paraneoplastic Ma antigen family-like 2; paraneoplastic antigen-like protein 8B", "tax_id": 10116, "disease": "", "pathway": " (rno:308393)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZQV3-1", "uniprot_id": "D3ZQV3_RAT", "mass": 38837.0, "length": 355, "protein_name": "Muscleblind-like splicing regulator 3", "gene_name": "Mbnl3", "organism": "Rat", "refseq_name": "muscleblind-like protein 3 isoform X5", "refseq_ac": "XP_038955539", "gene_names_uniprotkb": "Mbnl3", "gene_names_refseq": "Mbnl3; RGD1565834", "protein_names_uniprotkb": "Muscleblind-like splicing regulator 3", "protein_names_refseq": "muscleblind-like protein 3 isoform X5", "tax_id": 10116, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonic disease (Disease Ontology:DOID:450)", "pathway": " (rno:302492)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0043484 regulation of RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0045662 negative regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZQV8-1", "uniprot_id": "D3ZQV8_RAT", "mass": 41097.0, "length": 364, "protein_name": "PHD finger protein 6", "gene_name": "Phf6", "organism": "Rat", "refseq_name": "PHD finger protein 6", "refseq_ac": "NP_001389157", "gene_names_uniprotkb": "Phf6", "gene_names_refseq": "Phf6", "protein_names_uniprotkb": "PHD finger protein 6", "protein_names_refseq": "PHD finger protein 6", "tax_id": 10116, "disease": "Borjeson-Forssman-Lehmann syndrome (Disease Ontology:DOID:0050681); colorectal carcinoma (Disease Ontology:DOID:0080199); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:100359714); (R-RNO-9940951)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0043021 ribonucleoprotein complex binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000776 kinetochore", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZQV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZR21-1", "uniprot_id": "D3ZR21_RAT", "mass": 91195.0, "length": 824, "protein_name": "NTPase, KAP family P-loop domain containing 1", "gene_name": "Nkpd1", "organism": "Rat", "refseq_name": "NTPase KAP family P-loop domain-containing protein 1 isoform 1", "refseq_ac": "NP_001419406", "gene_names_uniprotkb": "Nkpd1", "gene_names_refseq": "Nkpd1", "protein_names_uniprotkb": "NTPase, KAP family P-loop domain containing 1", "protein_names_refseq": "NTPase KAP family P-loop domain-containing protein 1 isoform 1; 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Publication Status: Online-Only, [RefSeq, PubMed]; Findings define a molecular mechanism for Jak2/Stat5 mediated Suppressor of cytokine signalling-6 (SOCS6) signalling., [RefSeq, PubMed]; MiR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6. Publication Status: Online-Only, [RefSeq, PubMed]; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 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RGD1309316; Sack1e", "protein_names_uniprotkb": "Family with sequence similarity 83, member E", "protein_names_refseq": "family with sequence similarity 83, member E; protein FAM83E", "tax_id": 10116, "disease": "", "pathway": " (rno:292913)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZT45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZT84-1", "uniprot_id": "D3ZT84_RAT", "mass": 40054.0, "length": 375, "protein_name": "Alcohol dehydrogenase 6A (class V)", "gene_name": "Adh6a", "organism": "Rat", "refseq_name": "alcohol dehydrogenase 6A (class V)", "refseq_ac": "NP_001099945", "gene_names_uniprotkb": "Adh6a", "gene_names_refseq": "Adh6a", "protein_names_uniprotkb": "Alcohol dehydrogenase 6A (class V)", "protein_names_refseq": "alcohol dehydrogenase 6A (class V)", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0042573 retinoic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZT84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZT98-1", "uniprot_id": "D3ZT98_RAT", "mass": 12297.0, "length": 110, "protein_name": "BolA-like protein 3", "gene_name": "Bola3", "organism": "Rat", "refseq_name": "bolA-like protein 3", "refseq_ac": "NP_001100071", "gene_names_uniprotkb": "Bola3", "gene_names_refseq": "Bola3; RGD1305975", "protein_names_uniprotkb": "BolA-like protein 3", "protein_names_refseq": "bolA homolog 3; bolA-like protein 3", "tax_id": 10116, "disease": "multiple mitochondrial dysfunctions syndrome 2 (Disease Ontology:DOID:0080134)", "pathway": " (rno:297388)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005739 mitochondrion;GO:1990229 iron-sulfur cluster assembly complex", "go_biological_process": "GO:0051604 protein maturation;GO:0016226 iron-sulfur cluster assembly;GO:0097009 energy homeostasis;GO:0006006 glucose metabolic process;GO:0009249 protein lipoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZT98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZTA8-1", "uniprot_id": "D3ZTA8_RAT", "mass": 136446.0, "length": 1223, "protein_name": "RNA-binding protein 33", "gene_name": "Rbm33", "organism": "Rat", "refseq_name": "RNA-binding protein 33", "refseq_ac": "NP_001178788", "gene_names_uniprotkb": "Rbm33", "gene_names_refseq": "RGD1310651; Rbm33", "protein_names_uniprotkb": "RNA-binding protein 33; Proline-rich protein 8; RNA-binding motif protein 33", "protein_names_refseq": "RNA-binding protein 33-like; RNA-binding protein 33", "tax_id": 10116, "disease": "", "pathway": " (rno:362297)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation. Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5. Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:1990247 N6-methyladenosine-containing RNA reader activity;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043488 regulation of mRNA stability;GO:0051028 mRNA transport;GO:0006405 RNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZTA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZTI3-1", "uniprot_id": "D3ZTI3_RAT", "mass": 84092.0, "length": 781, "protein_name": "Cadherin-24", "gene_name": "Cdh24", "organism": "Rat", "refseq_name": "cadherin-24 precursor", "refseq_ac": "NP_001414210", "gene_names_uniprotkb": "Cdh24", "gene_names_refseq": "Cdh24; RGD1560161", "protein_names_uniprotkb": "Cadherin-24", "protein_names_refseq": "cadherin 24, type 2; cadherin-24 precursor; cadherin-like 24", "tax_id": 10116, "disease": "", "pathway": " (rno:498515); (R-RNO-418990)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0045294 alpha-catenin binding;GO:0070097 delta-catenin binding", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0016342 catenin complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0098609 cell-cell adhesion;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZTJ3-1", "uniprot_id": "D3ZTJ3_RAT", "mass": 178495.0, "length": 1599, "protein_name": "ADAM metallopeptidase with thrombospondin type 1 motif, 12", "gene_name": "Adamts12", "organism": "Rat", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor", "refseq_ac": "NP_001099890", "gene_names_uniprotkb": "Adamts12", "gene_names_refseq": "Adamts12", "protein_names_uniprotkb": "ADAM metallopeptidase with thrombospondin type 1 motif, 12", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor; A disintegrin and metalloproteinase with thrombospondin motifs 12; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061)", "pathway": " (rno:294809); (R-RNO-5173214)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21869572;37400752", "class_list": "", "function": "ADAMTS-7 and ADAMTS-12 expression were dramatically increased during disc degeneration., [RefSeq, PubMed]; Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0006508 proteolysis;GO:0016477 cell migration;GO:0030198 extracellular matrix organization;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZTJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZTM5-1", "uniprot_id": "D3ZTM5_RAT", "mass": 15577.0, "length": 136, "protein_name": "Piercer of microtubule wall 1", "gene_name": "Pierce1", "organism": "Rat", "refseq_name": "piercer of microtubule wall 1 protein", "refseq_ac": "NP_001100034", "gene_names_uniprotkb": "Pierce1; RGD1306233", "gene_names_refseq": "Pierce1; RGD1306233", "protein_names_uniprotkb": "Piercer of microtubule wall 1", "protein_names_refseq": "UPF0691 protein C9orf116 homolog; piercer of microtubule wall 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:296608)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0006974 DNA damage response;GO:0007368 determination of left/right symmetry;GO:0010468 regulation of gene expression;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZTN6-1", "uniprot_id": "D3ZTN6_RAT", "mass": 23490.0, "length": 205, "protein_name": "SREBP regulating gene protein", "gene_name": "Spring1", "organism": "Rat", "refseq_name": "SREBP regulating gene protein", "refseq_ac": "NP_001102536", "gene_names_uniprotkb": "Spring1; RGD1562310", "gene_names_refseq": "RGD1562310; Spring1", "protein_names_uniprotkb": "SREBP regulating gene protein", "protein_names_refseq": "SREBP regulating gene protein; UPF0454 protein C12orf49 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:498188)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:2000640 positive regulation of SREBP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZTY6-1", "uniprot_id": "D3ZTY6_RAT", "mass": 49345.0, "length": 462, "protein_name": "Major facilitator superfamily domain containing 9", "gene_name": "Slc67a2", "organism": "Rat", "refseq_name": "major facilitator superfamily domain-containing protein 9 isoform X1", "refseq_ac": "XP_006244885", "gene_names_uniprotkb": "Slc67a2; Mfsd9", "gene_names_refseq": "Mfsd9; RGD1562212", "protein_names_uniprotkb": "Major facilitator superfamily domain containing 9", "protein_names_refseq": "major facilitator superfamily domain-containing protein 9 isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZTZ3-1", "uniprot_id": "D3ZTZ3_RAT", "mass": 23127.0, "length": 211, "protein_name": "Ring finger protein 222", "gene_name": "Rnf222", "organism": "Rat", "refseq_name": "RING finger protein 222", "refseq_ac": "NP_001102298", "gene_names_uniprotkb": "Rnf222", "gene_names_refseq": "RGD1310573; Rnf222", "protein_names_uniprotkb": "Ring finger protein 222", "protein_names_refseq": "RING finger protein 222", "tax_id": 10116, "disease": "", "pathway": " (rno:363627)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, 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"go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZU50-1", "uniprot_id": "D3ZU50_RAT", "mass": 84327.0, "length": 770, "protein_name": "F-box and leucine-rich repeat protein 18", "gene_name": "Fbxl18", "organism": "Rat", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fbxl18", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box and leucine-rich repeat protein 18", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZU50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZU79-1", "uniprot_id": "D3ZU79_RAT", "mass": 14446.0, "length": 128, "protein_name": "Leucine-rich single-pass membrane protein 1", "gene_name": "Lsmem1", "organism": "Rat", "refseq_name": "leucine-rich single-pass membrane protein 1", "refseq_ac": "NP_001385612", "gene_names_uniprotkb": "Lsmem1", "gene_names_refseq": "Lsmem1", "protein_names_uniprotkb": "Leucine-rich single-pass membrane protein 1", "protein_names_refseq": "leucine-rich single-pass membrane protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:680810)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZU79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZUE5-1", "uniprot_id": "D3ZUE5_RAT", "mass": 13629.0, "length": 116, "protein_name": "Protein FAM32A", "gene_name": "Fam32al1", "organism": "Rat", "refseq_name": "uncharacterized protein LOC365238", "refseq_ac": "NP_001102383", "gene_names_uniprotkb": "Fam32al1; LOC365238", "gene_names_refseq": "Fam32al1", "protein_names_uniprotkb": "Protein FAM32A", "protein_names_refseq": "uncharacterized protein LOC365238", "tax_id": 10116, "disease": "", "pathway": " (rno:365238)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZUE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZUL4-1", "uniprot_id": "D3ZUL4_RAT", "mass": 23556.0, "length": 218, "protein_name": "BAF chromatin remodeling complex subunit BCL7C", "gene_name": "Bcl7c", "organism": "Rat", "refseq_name": "B-cell CLL/lymphoma 7 protein family member C isoform X3", "refseq_ac": "XP_006230318", "gene_names_uniprotkb": "Bcl7c", "gene_names_refseq": "Bcl7c", "protein_names_uniprotkb": "BAF chromatin remodeling complex subunit BCL7C", "protein_names_refseq": "B-cell CLL/lymphoma 7 protein family member C isoform X3", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-9933937); (R-RNO-9933939); (R-RNO-9933946); (R-RNO-9933947); (R-RNO-9934037)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016514 SWI/SNF complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZUL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3ZUT9-1", "uniprot_id": "D3ZUT9_RAT", "mass": 120620.0, "length": 1066, "protein_name": "Integrator complex subunit 3", "gene_name": "Ints3", "organism": "Rat", "refseq_name": "integrator complex subunit 3 isoform X1", "refseq_ac": "XP_017446796", "gene_names_uniprotkb": "Ints3", "gene_names_refseq": "Ints3; RGD1304593", "protein_names_uniprotkb": "Integrator complex subunit 3", "protein_names_refseq": "integrator complex subunit 3 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-6807505)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0035861 site of double-strand break;GO:0032039 integrator complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZUT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C6U8-1", "uniprot_id": "R1A_SARS", "mass": 486373.0, "length": 4382, "protein_name": "Replicase polyprotein 1a", "gene_name": "1a", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Replicase polyprotein 1a; 2.7.7.50; GFL; Growth factor-like peptide; Leader protein; Main protease; Mpro; Non-structural protein 1; Non-structural protein 3; Non-structural protein 5; Non-structural protein 9; ORF1a polyprotein; PL2-PRO; SARS coronavirus main proteinase; nsp1; nsp3; nsp5; nsp9; p65 homolog; pp1a", "protein_names_refseq": "", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 43, "publication_id_list": "12730500;12730501;12746549;12781537;12853594;12876307;12917450;12925794;12958366;14527350;14561748;14645828;14962394;15007178;15331731;15507456;15564471;16226257;16228002;16271890;16306590;16581910;16873246;16873247;17024178;17202208;17532020;17692280;18842706;19153232;19369340;19640993;21345958;22039154;22174690;22635272;23035226;23943763;24410069;24622840;24991833;30943371;32083638", "class_list": "", "function": "Catalytic subunit of viral RNA capping enzyme which catalyzes the RNA guanylyltransferase reaction for genomic and sub-genomic RNAs. The kinase-like NiRAN domain of NSP12 transfers RNA to the amino terminus of NSP9, forming a covalent RNA-protein intermediate. Subsequently, the NiRAN domain transfers RNA to GDP, forming the core cap structure GpppA-RNA. The NSP14 and NSP16 methyltransferases then add methyl groups to form functional cap structures., [UniProtKB, UniProtKB, PubMed]; Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP). May cleave host ATP6V1G1 thereby modifying host vacuoles intracellular pH., [UniProtKB, PubMed, UniProtKB]; Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers., [UniProtKB, PubMed]; Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers., [UniProtKB, PubMed]; Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (PubMed:23035226). May disrupt nuclear pore function by binding and displacing host NUP93 (PubMed:30943371)., [UniProtKB, PubMed, PubMed]; May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2 (PubMed:19640993). Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses (PubMed:19640993)., [UniProtKB, PubMed]; Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein., [UniProtKB, UniProtKB]; Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation., [UniProtKB, PubMed]; Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication (PubMed:23943763, PubMed:24410069). Alone appears incapable to induce membrane curvature, but together with nsp3 is able to induce paired membranes (PubMed:23943763). Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:23943763, PubMed:24410069)., [UniProtKB, PubMed, PubMed, PubMed]; Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:17692280). Contains an ADP-ribose hydrolase activity that binds ADP-ribose and catalyzes the removal of mono-ADP-ribose (de-MARylation), usually bound to a glutamate or aspartate (By similarity). ADP-ribose hydrolase activity allows the virus to interfere with the host immune defenses involving poly-ADP-ribose polymerases (PARPs) (Probable). Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication (PubMed:23943763). Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:23943763, PubMed:24410069). Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:19369340, PubMed:24622840). Also prevents host NF-kappa-B signaling (PubMed:19369340, PubMed:24622840)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P59641", "ec_number_list": "", "go_molecular_function": "GO:0003968 RNA-directed RNA polymerase activity;GO:0008242 omega peptidase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0044220 host cell perinuclear region of cytoplasm;GO:0044165 host cell endoplasmic reticulum;GO:0044177 host cell Golgi apparatus;GO:0044174 host cell endosome;GO:0062243 double membrane vesicle viral factory outer membrane", "go_biological_process": "GO:0019082 viral protein processing;GO:0006508 proteolysis;GO:0019079 viral genome replication;GO:0032259 methylation;GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P0C6U8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C6X7-1", "uniprot_id": "R1AB_SARS", "mass": 790248.0, "length": 7073, "protein_name": "Replicase polyprotein 1ab", "gene_name": "rep", "organism": "HCoV-SARS", "refseq_name": "ORF1ab polyprotein", "refseq_ac": "NP_828849", "gene_names_uniprotkb": "rep; 1a-1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Replicase polyprotein 1ab; ExoN; GFL; Growth factor-like peptide; Leader protein; Main protease; Mpro; NendoU; Non-structural protein 12; Non-structural protein 13; Non-structural protein 14; Non-structural protein 15; Non-structural protein 16; Non-structural protein 1; Non-structural protein 3; Non-structural protein 5; Non-structural protein 9; ORF1ab polyprotein; PL2-PRO; Proofreading exoribonuclease nsp14; RNA-capping enzyme subunit nsp9; SARS coronavirus main proteinase; nsp12; nsp13; nsp14; nsp15; nsp16; nsp1; nsp3; nsp5; nsp9; p65 homolog; pp1ab", "protein_names_refseq": "ORF1ab polyprotein; polyprotein pp1ab; replicase 1AB", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 62, "publication_id_list": "12730500;12730501;12746549;12781537;12853594;12876307;12917423;12917450;12925794;12958366;14527350;14561748;14645828;14962394;15007178;15331731;15507456;15564471;16226257;16228002;16271890;16306590;16549795;16581910;16828802;16873246;16873247;16882730;17024178;17202208;17532020;17692280;17855519;18045871;18417574;18827877;18842706;19153232;19369340;19640993;20421945;20573827;21345958;21593585;22022266;22039154;22174690;22615777;22635272;22791111;23035226;23943763;23966862;24410069;24622840;24991833;28158275;29511076;30943371;32083638;34845015;35594856", "class_list": "", "function": "Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. May cleave human NLRP1 in lung epithelial cells, thereby activating the NLRP1 inflammasome pathway (PubMed:35594856). Also able to bind an ADP-ribose-1''-phosphate (ADRP). May cleave host ATP6V1G1 thereby modifying host vacuoles intracellular pH., [UniProtKB, PubMed, PubMed, UniProtKB]; Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers., [UniProtKB, PubMed]; Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers., [UniProtKB, PubMed]; Forms a primer, NSP9-pU, which is utilized by the polymerase for the initiation of RNA chains. Interacts with ribosome signal recognition particle RNA (SRP). Together with NSP8, suppress protein integration into the cell membrane, thereby disrupting host immune defenses., [UniProtKB, UniProtKB]; Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (PubMed:23035226). May disrupt nuclear pore function by binding and displacing host NUP93 (PubMed:30943371)., [UniProtKB, PubMed, PubMed]; May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2 (PubMed:19640993). Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses (PubMed:19640993)., [UniProtKB, PubMed]; Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs (PubMed:18417574, PubMed:20421945, PubMed:22022266). N7-methyl guanosine cap is a prerequisite for binding of nsp16 (PubMed:18417574). Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system (PubMed:18417574, PubMed:20421945, PubMed:22022266)., [UniProtKB, PubMed, PubMed, PubMed]; Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium., [UniProtKB, PubMed, PubMed]; Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein., [UniProtKB, PubMed]; Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation., [UniProtKB, PubMed, PubMed]; Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication (PubMed:23943763). Alone appears incapable to induce membrane curvature, but together with nsp3 is able to induce paired membranes. Nsp3, nsp4 and nsp6 together are sufficient to form DMV., [UniProtKB, PubMed, PubMed, PubMed]; Plays a role in viral RNA synthesis through two distinct activities. The N7-guanine methyltransferase activity plays a role in the formation of the cap structure GpppA-RNA (PubMed:20421945, PubMed:34845015). The proofreading exoribonuclease reduces the sensitivity of the virus to RNA mutagens during replication (PubMed:16549795, PubMed:21593585, PubMed:22635272, PubMed:23966862, PubMed:29511076). This activity acts on both ssRNA and dsRNA in a 3'-5' direction., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Plays a role in viral transcription/replication and prevents the simultaneous activation of host cell dsRNA sensors, such as MDA5/IFIH1, OAS, and PKR (PubMed:18045871, PubMed:28158275). Acts by degrading the 5'-polyuridines generated during replication of the poly(A) region of viral genomic and subgenomic RNAs. Catalyzes a two-step reaction in which a 2'3'-cyclic phosphate (2'3'-cP) is first generated by 2'-O transesterification, which is then hydrolyzed to a 3'-phosphate (3'-P) (PubMed:16828802). If not degraded, poly(U) RNA would hybridize with poly(A) RNA tails and activate host dsRNA sensors (PubMed:18045871, PubMed:28158275)., [UniProtKB, PubMed, PubMed, PubMed]; RNA-directed RNA polymerase that catalyzes the transcription of viral genomic and subgenomic RNAs (PubMed:22791111). Acts in complex with nsp7 and nsp8 to transcribe both the minus and positive strands of genomic RNA. The kinase-like NiRAN domain of NSP12 attaches one or more nucleotides to the amino terminus of NSP9, forming a covalent RNA-protein intermediate that serves as transcription/replication primer. Subgenomic RNAs (sgRNAs) are formed by discontinuous transcription: The polymerase has the ability to pause at transcription-regulating sequences (TRS) and jump to the leader TRS, resulting in a major deletion. This creates a series of subgenomic RNAs that are replicated, transcribed and translated. In addition, Nsp12 is a subunit of the viral RNA capping enzyme that catalyzes the RNA guanylyltransferase reaction for genomic and sub-genomic RNAs. Subsequently, the NiRAN domain transfers RNA to GDP, and forms the core cap structure GpppA-RNA., [UniProtKB, UniProtKB, PubMed]; Responsible for the cleavages located at the N-terminus of the replicase polyprotein (PubMed:16306590). Contains an ADP-ribose hydrolase activity that binds ADP-ribose and catalyzes the removal of mono-ADP-ribose (de-MARylation), usually bound to a glutamate or aspartate (By similarity). ADP-ribose hydrolase activity allows the virus to interfere with the host immune defenses involving poly-ADP-ribose polymerases (PARPs) (Probable). In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:16306590, PubMed:17692280). Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication (PubMed:23943763). Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:19369340, PubMed:24622840). Also prevents host NF-kappa-B signaling (PubMed:19369340, PubMed:24622840)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 23, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P59641;Q6WGN0;Q7T697;Q808C0;Q80BV7;Q80BV8;Q80E51", "ec_number_list": "", "go_molecular_function": "GO:0004483 methyltransferase cap1 activity;GO:0003968 RNA-directed RNA polymerase activity;GO:0005524 ATP binding;GO:0008242 omega peptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0044220 host cell perinuclear region of cytoplasm;GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment;GO:0044165 host cell endoplasmic reticulum;GO:0044177 host cell Golgi apparatus;GO:0044174 host cell endosome", "go_biological_process": "GO:0019082 viral protein processing;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0019083 viral transcription;GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 6.3, "record_id": "P0C6X7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59594-1", "uniprot_id": "SPIKE_SARS", "mass": 139125.0, "length": 1255, "protein_name": "Spike glycoprotein", "gene_name": "S", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "S; 2", "gene_names_refseq": "", "protein_names_uniprotkb": "Spike glycoprotein; E2; Peplomer protein; S glycoprotein", "protein_names_refseq": "", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 34, "publication_id_list": "10.1021/acs.analchem.0c03301;12730500;12730501;12781537;12853594;12876307;12917450;12958366;14511651;14647384;14670965;15194747;15313178;15345712;15450134;15496474;15518555;15604146;15695582;15791205;15831954;15890958;16081529;16166518;16519916;16698550;16840309;17134730;17166901;19321428;20861307;29056462;31199522;33064451", "class_list": "", "function": "Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis., [UniProtKB, PubMed, HAMAP]; Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membrane fusion within endosomes., [UniProtKB, PubMed, PubMed, HAMAP]; May down-regulate host tetherin (BST2) by lysosomal degradation, thereby counteracting its antiviral activity., [UniProtKB, PubMed]; Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 22, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 18, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 22, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 22, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 22, "disease_count": 1, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "Q6QU82;Q7T696;Q7TA19;Q7TFA2;Q7TFB1;Q80BV6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046789 host cell surface receptor binding", "go_cellular_component": "GO:0016020 membrane;GO:0019031 viral envelope;GO:0055036 virion membrane;GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0020002 host cell plasma membrane", "go_biological_process": "GO:0046598 positive regulation of viral entry into host cell;GO:0046813 receptor-mediated virion attachment to host cell;GO:0061025 membrane fusion;GO:0019064 fusion of virus membrane with host plasma membrane;GO:0039587 symbiont-mediated-mediated suppression of host tetherin activity", "synthesized_glycan_count": 0, "hit_score": 7.9, "record_id": "P59594-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59595-1", "uniprot_id": "NCAP_SARS", "mass": 46025.0, "length": 422, "protein_name": "Nucleoprotein", "gene_name": "N", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "N; 9a", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleoprotein; NC; Nucleocapsid protein; Protein N", "protein_names_refseq": "", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 26, "publication_id_list": "12730500;12730501;12781537;12853594;12876307;12917450;12958366;14527350;15147189;15351485;15688292;15862300;16041067;16627473;17210170;17229691;17379242;18055455;18155731;18561946;19106108;20844028;24766657;29199039;32974389;35922005", "class_list": "", "function": "Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455)., [UniProtKB, PubMed, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T3Z4;Q7TA14;Q7TF99;Q80E50", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0042025 host cell nucleus;GO:0005886 plasma membrane;GO:1990904 ribonucleoprotein complex;GO:0019028 viral capsid;GO:0019013 viral nucleocapsid", "go_biological_process": "GO:0019074 viral RNA genome packaging;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P59595-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59596-1", "uniprot_id": "VME1_SARS", "mass": 25061.0, "length": 221, "protein_name": "Membrane protein", "gene_name": "M", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "M; 5", "gene_names_refseq": "", "protein_names_uniprotkb": "Membrane protein; E1 glycoprotein; M protein; Matrix glycoprotein; Membrane glycoprotein", "protein_names_refseq": "", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 12, "publication_id_list": "12730500;12730501;12781537;12853594;12876307;12917450;12958366;15194747;15763150;16442106;16580632;19534833", "class_list": "", "function": "Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins., [UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6S8E5;Q7T6Q8;Q7T6R1;Q7T6R5;Q7T6S0;Q7T6S3;Q7T726;Q7T7P6;Q7T7S6;Q7TA12", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0039660 structural constituent of virion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0019031 viral envelope;GO:0055036 virion membrane;GO:0044178 host cell Golgi membrane", "go_biological_process": "GO:0052031 symbiont-mediated perturbation of host defense response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P59596-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59632-1", "uniprot_id": "AP3A_SARS", "mass": 30903.0, "length": 274, "protein_name": "ORF3a protein", "gene_name": "3a", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "3a", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF3a protein; Accessory protein 3a; Protein 3a; Protein U274; Protein X1", "protein_names_refseq": "", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 15, "publication_id_list": "12730500;12730501;12853594;12876307;15135062;15194747;15709039;15763150;15781262;15958670;16014971;16352545;16474139;16894145;20020050", "class_list": "", "function": "Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Down-regulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7T6R6;Q7TA10;Q7TA18;Q7TFB0;Q7TLD0;Q80BV5", "ec_number_list": "", "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0055036 virion membrane;GO:0044178 host cell Golgi membrane;GO:0020002 host cell plasma membrane", "go_biological_process": "GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway;GO:0052170 symbiont-mediated suppression of host innate immune response;GO:0141079 symbiont-mediated activation of host inflammasome-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P59632-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59633-1", "uniprot_id": "NS3B_SARS", "mass": 17750.0, "length": 154, "protein_name": "ORF3b protein", "gene_name": "3b", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "3b", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF3b protein; Accessory protein 3b; Non-structural protein 3b; Protein X2; ns3b", "protein_names_refseq": "", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "12730500;12730501;12853594;12876307;16046244;16107218;16682811;22253733", "class_list": "", "function": "Induces host cell G0/G1 arrest and apoptosis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TFA9;Q80BV4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0033650 host cell mitochondrion;GO:0044196 host cell nucleolus", "go_biological_process": "GO:0001817 regulation of cytokine production;GO:0039646 symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint;GO:0052150 symbiont-mediated perturbation of host apoptosis;GO:0044071 symbiont-mediated perturbation of host cell cycle progression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P59633-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59634-1", "uniprot_id": "NS6_SARS", "mass": 7527.0, "length": 63, "protein_name": "ORF6 protein", "gene_name": "6", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "6", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF6 protein; Accessory protein 6; Non-structural protein 6; ORF6; Protein X3; ns6", "protein_names_refseq": "", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 13, "publication_id_list": "12730500;12730501;12853594;12876307;16103185;16310783;17108045;17532020;17596301;22026976;22820404;33849972;35096974", "class_list": "", "function": "Disrupts bidirectional nucleocytoplasmic transport by interacting with host RAE1-NUP98 complex (PubMed:33849972). Disrupts cell nuclear import complex formation also by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane (PubMed:17596301). Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus (PubMed:17596301). Thereby prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (PubMed:17596301)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T6R9;Q7TA25;Q7TFA7;Q80BV3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0044178 host cell Golgi membrane;GO:0044167 host cell endoplasmic reticulum membrane", "go_biological_process": "GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway;GO:0039563 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity;GO:0052170 symbiont-mediated suppression of host innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P59634-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59635-1", "uniprot_id": "NS7A_SARS", "mass": 13941.0, "length": 122, "protein_name": "ORF7a protein", "gene_name": "7a", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "7a", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF7a protein; Accessory protein 7a; Protein U122; Protein X4", "protein_names_refseq": "", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 15, "publication_id_list": "12730500;12730501;12853594;12876307;15194747;15220404;15564512;15642263;16328780;16580632;16840309;17037516;18020948;20631126;26378163", "class_list": "", "function": "Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. Acts by binding to BST2 thereby interfering with its glycosylation. May suppress small interfering RNA (siRNA). May bind to host ITGAL, thereby playing a role in attachment or modulation of leukocytes., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TA11;Q7TA17", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0055036 virion membrane;GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0044178 host cell Golgi membrane;GO:0044165 host cell endoplasmic reticulum", "go_biological_process": "GO:0039587 symbiont-mediated-mediated suppression of host tetherin activity;GO:0039646 symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint;GO:0052151 symbiont-mediated activation of host apoptosis;GO:0052170 symbiont-mediated suppression of host innate immune response;GO:0044071 symbiont-mediated perturbation of host cell cycle progression", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P59635-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59636-1", "uniprot_id": "ORF9B_SARS", "mass": 10802.0, "length": 98, "protein_name": "ORF9b protein", "gene_name": "9b", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "9b", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF9b protein; Accessory protein 9b; ORF-9b; Protein 9b", "protein_names_refseq": "", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 12, "publication_id_list": "12730500;12730501;12853594;12876307;12917450;14527350;16843897;17448558;19394665;21637748;22820404;25135833", "class_list": "", "function": "Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T6R2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0042025 host cell nucleus;GO:0005741 mitochondrial outer membrane;GO:0044423 virion component;GO:0033650 host cell mitochondrion;GO:0044162 host cell cytoplasmic vesicle membrane", "go_biological_process": "GO:0090258 negative regulation of mitochondrial fission;GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway;GO:2000786 positive regulation of autophagosome assembly;GO:0050687 negative regulation of defense response to virus;GO:0039545 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P59636-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59637-1", "uniprot_id": "VEMP_SARS", "mass": 8361.0, "length": 76, "protein_name": "Envelope small membrane protein", "gene_name": "E", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "E; 4; sM", "gene_names_refseq": "", "protein_names_uniprotkb": "Envelope small membrane protein; E protein; sM protein", "protein_names_refseq": "", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 18, "publication_id_list": "12730500;12730501;12781537;12853594;12876307;12917450;12958366;14527350;15194747;15763150;16580632;19322648;20861307;21450821;22819936;24766657;24788150;26331680", "class_list": "", "function": "Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction., [UniProtKB, PubMed, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TA13;Q7TFA8", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0016020 membrane;GO:0055036 virion membrane;GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment;GO:0044178 host cell Golgi membrane;GO:0044177 host cell Golgi apparatus", "go_biological_process": "GO:0051673 disruption of plasma membrane integrity in another organism;GO:0046760 viral budding from Golgi membrane", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P59637-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TFA0-1", "uniprot_id": "NS8A_SARS", "mass": 4327.0, "length": 39, "protein_name": "ORF8a protein", "gene_name": "8a", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "8a", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF8a protein; Accessory protein 8a; Protein non-structural 8a; ns8a", "protein_names_refseq": "", "tax_id": 694009, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "12730500;12730501;12917450", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TLC8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TFA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TFA1-1", "uniprot_id": "NS7B_SARS", "mass": 5302.0, "length": 44, "protein_name": "Protein non-structural 7b", "gene_name": "7b", "organism": "HCoV-SARS", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "7b", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein non-structural 7b; 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