[ { "uniprot_canonical_ac": "P38532-1", "uniprot_id": "HSF1_MOUSE", "mass": 57223.0, "length": 525, "protein_name": "Heat shock factor protein 1", "gene_name": "Hsf1", "organism": "Mouse", "refseq_name": "heat shock factor protein 1 isoform alpha", "refseq_ac": "NP_001318083", "gene_names_uniprotkb": "Hsf1", "gene_names_refseq": "HSTF 1; HSTF; Hsf1alpha; Hsf1beta; Hsf1", "protein_names_uniprotkb": "Heat shock factor protein 1; HSF 1; HSTF 1; Heat shock transcription factor 1", "protein_names_refseq": "heat shock factor protein 1 isoform alpha; heat shock factor protein 1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); cryptorchidism (Disease Ontology:DOID:11383); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:15499); (R-MMU-3371453); (R-MMU-3371511); (R-MMU-3371568); (R-MMU-3371571); (R-MMU-9841251)", "pathway_count": 6, "publication_count": 21, "publication_id_list": "1717345;18596307;19131326;20231359;21750661;24384723;24855652;25027850;25752395;25901028;26159920;26620638;28091697;28128329;28717943;29941492;30059200;31244938;31516744;33177089;9829985", "class_list": "", "function": "After heat shock, HSF1gamma isoforms are exported from the nucleus more rapidly or degraded more quickly than HSF1alpha or HSF1beta, [RefSeq, PubMed]; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes. Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival. Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences. Binds to chromatin at heat shock gene promoters. Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (By similarity). Binds the promoter region upstream of exon 1 of Mpv17l to activate expression of the M-LPS isoform which is involved in metabolism of reactive oxygen species (PubMed:20231359). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner. Plays a role in nuclear export of stress-induced HSP70 mRNA. Plays a role in the regulation of mitotic progression. Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner. Involved in stress-induced cancer cell proliferation in a IER5-dependent manner., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O70462", "ec_number_list": "", "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0090084 negative regulation of inclusion body assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P38532-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38533-1", "uniprot_id": "HSF2_MOUSE", "mass": 60225.0, "length": 535, "protein_name": "Heat shock factor protein 2", "gene_name": "Hsf2", "organism": "Mouse", "refseq_name": "heat shock factor protein 2", "refseq_ac": "NP_032323", "gene_names_uniprotkb": "Hsf2", "gene_names_refseq": "Hsf2", "protein_names_uniprotkb": "Heat shock factor protein 2; HSF 2; HSTF 2; Heat shock transcription factor 2", "protein_names_refseq": "HSF 2; HSTF 2; heat shock factor protein 2; heat shock transcription factor 2", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:15500)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10333528;1717345;21750661;34428180;7565677", "class_list": "", "function": "DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. HSF2 is expressed in a form that binds DNA constitutively but loses DNA binding by incubation at greater than 41 degrees C., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64157;Q8VEJ0;Q9Z2L8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P38533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42581-1", "uniprot_id": "HMX3_MOUSE", "mass": 37859.0, "length": 356, "protein_name": "Homeobox protein HMX3", "gene_name": "Hmx3", "organism": "Mouse", "refseq_name": "homeobox protein HMX3", "refseq_ac": "NP_032283", "gene_names_uniprotkb": "Hmx3; Nkx-5.1; Nkx5-1", "gene_names_refseq": "Hmx3; Nkx-5.1; Nkx5-1; Nkx5.1", "protein_names_uniprotkb": "Homeobox protein HMX3; Homeobox protein H6 family member 3; Homeobox protein Nkx-5.1", "protein_names_refseq": "H6 homeo box 3; homeobox protein H6 family member 3; homeobox protein HMX3; homeobox protein Nkx-5.1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15373)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10206974;10543441;11731242;11748138;12874121;14695375;15363417;7510254;8541222;8970821;9389661;9435283", "class_list": "", "function": "Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EIJ0;O88699", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0042472 inner ear morphogenesis;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P42581-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49182-1", "uniprot_id": "HEP2_MOUSE", "mass": 54497.0, "length": 478, "protein_name": "Heparin cofactor 2", "gene_name": "Serpind1", "organism": "Mouse", "refseq_name": "heparin cofactor 2 precursor", "refseq_ac": "NP_001317976", "gene_names_uniprotkb": "Serpind1; Hcf2; Hcii", "gene_names_refseq": "HC-II; HCII; Hcf2; Serpind1", "protein_names_uniprotkb": "Heparin cofactor 2; HC-II; Heparin cofactor II; Protease inhibitor leuserpin-2; Serpin D1", "protein_names_refseq": "heparin cofactor 2 precursor; heparin cofactor 2; heparin cofactor II; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1; serpin D1", "tax_id": 10090, "disease": "disease by infectious agent (Disease Ontology:DOID:0050117); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); heparin cofactor II deficiency (Disease Ontology:DOID:0111901); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (mmu:15160); (R-MMU-381426); (R-MMU-8957275); (R-MMU-9769733); (R-MMU-9769739); (R-MMU-9769743)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16944957;23656734;26495903;26740625;28502917;30870413;32152506;37507081;7908224", "class_list": "", "function": "In this study, we demonstrate a previously unknown role for HCII in host defense, [RefSeq, PubMed]; Loss of Heparin Cofactor is associated with insulin resistance ., [RefSeq, PubMed]; Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner., [UniProtKB]; Trancriptomic analysis shows that expression of the antithrombins serpin C1 and D1 is significantly reduced in Schwann cell-deficient mice. In the absence of peripheral neuromuscular activity, neurodegeneration is completely blocked, and expression of prothrombin in muscle is markedly reduced. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P49182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62816-1", "uniprot_id": "HRK_MOUSE", "mass": 10078.0, "length": 92, "protein_name": "Activator of apoptosis harakiri", "gene_name": "Hrk", "organism": "Mouse", "refseq_name": "activator of apoptosis harakiri", "refseq_ac": "NP_031571", "gene_names_uniprotkb": "Hrk; Bid3; Dp5", "gene_names_refseq": "Bid3; DP5; Hrk; harakiri", "protein_names_uniprotkb": "Activator of apoptosis harakiri; BH3-interacting domain-containing protein 3; Neuronal death protein DP5", "protein_names_refseq": "BH3 interacting (with BCL2 family) domain, apoptosis agonist; BH3-interacting domain-containing protein 3; activator of apoptosis harakiri; neuronal death protein DP5", "tax_id": 10090, "disease": "", "pathway": " (mmu:12123)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15084651;17535852;18037991;18846829;9228060", "class_list": "", "function": "DP5 plays an important role in neuronal cell death induced by axotomy and NGF deprivation through the regulation of mitochondrial function and caspase-3 activation Erratum:[J Neurosci. 2004 May 5;24(18):4488. Leiberman AP [corrected to Lieberman AP]], [RefSeq, PubMed]; In response to PAHs, Ahr-mediated activation of the harakiri, BCL2 interacting protein (contains only BH3 domain), was necessary for execution of cell death., [RefSeq, PubMed]; Promotes apoptosis., [UniProtKB]; The effect of antisense oligonucleoties specific to the harakiri mRNA on spontaneous and induced defects of mouse preimplantation embryo development, [RefSeq, PubMed]; These results demonstrate that HRK contributes to apoptosis signalling elicited by trophic factor withdrawal in certain neuronal populations but is dispensable for apoptosis of haematopoietic cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70678", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0051365 cellular response to potassium ion starvation;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0031334 positive regulation of protein-containing complex assembly;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62816-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70120-1", "uniprot_id": "HES5_MOUSE", "mass": 18425.0, "length": 167, "protein_name": "Transcription factor HES-5", "gene_name": "Hes5", "organism": "Mouse", "refseq_name": "transcription factor HES-5 isoform 1", "refseq_ac": "NP_034549", "gene_names_uniprotkb": "Hes5; Hes-5", "gene_names_refseq": "Hes5; bHLHb38", "protein_names_uniprotkb": "Transcription factor HES-5; Hairy and enhancer of split 5", "protein_names_refseq": "hairy and enhancer of split 5; transcription factor HES-5 isoform 1; transcription factor HES-5", "tax_id": 10090, "disease": "diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:15208)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23160044;32055024;7836401", "class_list": "", "function": "Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVI1", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046983 protein dimerization activity;GO:0003690 double-stranded DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021781 glial cell fate commitment;GO:0072086 specification of loop of Henle identity;GO:2000981 negative regulation of inner ear receptor cell differentiation;GO:0045608 negative regulation of inner ear auditory receptor cell differentiation;GO:0048708 astrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70120-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02576-1", "uniprot_id": "HEN1_MOUSE", "mass": 14830.0, "length": 133, "protein_name": "Helix-loop-helix protein 1", "gene_name": "Nhlh1", "organism": "Mouse", "refseq_name": "helix-loop-helix protein 1", "refseq_ac": "NP_035046", "gene_names_uniprotkb": "Nhlh1; Hen1", "gene_names_refseq": "Hen1; Nhlh1; Nscl; Tal2; bHLHa35", "protein_names_uniprotkb": "Helix-loop-helix protein 1; HEN-1; NSCL-1; Nescient helix loop helix 1", "protein_names_refseq": "HELIX-LOOP-HELIX PROTEIN 1 (HEN1) (NSCL); HEN-1; NSCL-1; helix-loop-helix protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18071)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1528853;1729708;38388750", "class_list": "", "function": "May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system., [UniProtKB]; Nescient helix-loop-helix 1 (Nhlh1) is a novel activating transcription factor 5 (ATF5) target gene in olfactory and vomeronasal sensory neurons in mice. Erratum:[Cell Tissue Res. 2024 May;396(2):291-292. doi: 10.1007/s00441-024-03891-w. PMID: 38530437], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02576-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14DK5-1", "uniprot_id": "HIPL1_MOUSE", "mass": 87528.0, "length": 791, "protein_name": "HHIP-like protein 1", "gene_name": "Hhipl1", "organism": "Mouse", "refseq_name": "HHIP-like protein 1 precursor", "refseq_ac": "NP_001037845", "gene_names_uniprotkb": "Hhipl1; Hhip2; Kiaa1822", "gene_names_refseq": "1600002O04Rik; Hhipl1; mKIAA1822", "protein_names_uniprotkb": "HHIP-like protein 1", "protein_names_refseq": "HHIP-like protein 1 precursor; HHIP-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:214305)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;20485683;31163988;31219806", "class_list": "", "function": "HHIPL1 expression was detected in in smooth muscle within atherosclerotic plaques of Apoe(-/-) mice. Its expression increased with disease progression in aortic roots of these mice. Proliferation and migration were reduced in Hhipl1 knockout mouse and HHIPL1 knockdown aortic smooth muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q14CI0;Q3UGD3;Q3UU97;Q6ZPH6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0060840 artery development;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q14DK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1H3-1", "uniprot_id": "HPHL1_MOUSE", "mass": 130888.0, "length": 1159, "protein_name": "Ferroxidase HEPHL1", "gene_name": "Hephl1", "organism": "Mouse", "refseq_name": "ferroxidase HEPHL1 precursor", "refseq_ac": "NP_001158269", "gene_names_uniprotkb": "Hephl1; Gm509", "gene_names_refseq": "Gm509; Hephl1; Zp; cw; thd; zyklopen", "protein_names_uniprotkb": "Ferroxidase HEPHL1; 1.16.3.1; Hephaestin-like protein 1", "protein_names_refseq": "ferroxidase HEPHL1 precursor; ferroxidase HEPHL1; hephaestin-like protein 1; tail hair depletion", "tax_id": 10090, "disease": "", "pathway": " (mmu:244698)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24988611;31125343;31293895", "class_list": "", "function": "Is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe(2+) to Fe(3+) without releasing radical oxygen species. May be involved in the regulation of intracellular iron content., [UniProtKB, UniProtKB]; Reviewed available data indicate that zyklopen is responsible for the placental iron transport. Review article, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.16.3.1;1.11.1.27;1.11.1.9;1.16.3.4", "go_molecular_function": "GO:0005507 copper ion binding;GO:0004322 ferroxidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0006825 copper ion transport;GO:0060586 multicellular organismal-level iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3V1H3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SQP1-1", "uniprot_id": "HORM2_MOUSE", "mass": 34812.0, "length": 306, "protein_name": "HORMA domain-containing protein 2", "gene_name": "Hormad2", "organism": "Mouse", "refseq_name": "HORMA domain-containing protein 2", "refseq_ac": "NP_083734", "gene_names_uniprotkb": "Hormad2", "gene_names_refseq": "4930529M09Rik; Hormad2", "protein_names_uniprotkb": "HORMA domain-containing protein 2", "protein_names_refseq": "HORMA domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75828)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19851446;21183079;21750661;22346761;22549958;23039116;31599954;38401263", "class_list": "", "function": "Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation., [UniProtKB, PubMed, PubMed]; HORMAD1 and HORMAD2 are depleted from synapsed chromosome axes with the help of TRIP13., [RefSeq, PubMed]; The N-terminal modification of HORMAD2 causes its ectopic persistence on synapsed chromosomes without meiotic blockade. Publication Status: Online-Only, [RefSeq, PubMed]; These observations strongly suggest that HORMAD2-dependent recruitment of ATR to unsynapsed chromosome axes constitutes a mechanism for the surveillance of asynapsis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZMW2;Q9D507", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0007130 synaptonemal complex assembly;GO:0051321 meiotic cell cycle;GO:0051177 meiotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5SQP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61646-1", "uniprot_id": "HPT_MOUSE", "mass": 38752.0, "length": 347, "protein_name": "Haptoglobin", "gene_name": "Hp", "organism": "Mouse", "refseq_name": "haptoglobin isoform 1 preproprotein", "refseq_ac": "NP_059066", "gene_names_uniprotkb": "Hp", "gene_names_refseq": "HP-1; Hp; preHP2", "protein_names_uniprotkb": "Haptoglobin", "protein_names_refseq": "haptoglobin isoform 1 preproprotein; zonulin", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hepatocellular adenoma (Disease Ontology:DOID:0050868); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); alpha thalassemia (Disease Ontology:DOID:1099); sarcoidosis (Disease Ontology:DOID:11335); iron deficiency anemia (Disease Ontology:DOID:11758); beta thalassemia (Disease Ontology:DOID:12241); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); cardiovascular system disease (Disease Ontology:DOID:1287); dilated cardiomyopathy (Disease Ontology:DOID:12930); gout (Disease Ontology:DOID:13189); lung cancer (Disease Ontology:DOID:1324); Kawasaki disease (Disease Ontology:DOID:13378); cholestasis (Disease Ontology:DOID:13580); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); hyperglycemia (Disease Ontology:DOID:4195); liver cirrhosis (Disease Ontology:DOID:5082); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15439); (R-MMU-2168880); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;16944957;20571061;26495903;30084848;31573976;32101700;32152506;34428180;34789790;37453647;39114668", "class_list": "", "function": "As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity)., [UniProtKB]; Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei. Publication Status: Online-Only, [RefSeq, PubMed]; Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation., [RefSeq, PubMed]; Novel role of zonulin in the pathophysiology of gastro-duodenal transit: a clinical and translational study. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a plasma glycoprotein called haptoglobin that binds free hemoglobin. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta subunits that form a disulfide-linked tetrameric protein that plays an important role in the sequestration and clearance of extracorpuscular hemoglobin. Mice lacking the encoded protein exhibit stunted development of lymphoid organs associated with lower counts of mature T and B cells in the blood and secondary lymphoid compartments. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 42, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0016209 antioxidant activity;GO:0030492 hemoglobin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0072562 blood microparticle;GO:0034366 spherical high-density lipoprotein particle;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0001889 liver development;GO:0007219 Notch signaling pathway;GO:0006953 acute-phase response;GO:0009617 response to bacterium;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q61646-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61666-1", "uniprot_id": "HIRA_MOUSE", "mass": 111767.0, "length": 1015, "protein_name": "Protein HIRA", "gene_name": "Hira", "organism": "Mouse", "refseq_name": "protein HIRA", "refseq_ac": "NP_034565", "gene_names_uniprotkb": "Hira; Tuple1", "gene_names_refseq": "D16Ertd95e; Gm15797; Hira; Tuple1", "protein_names_uniprotkb": "Protein HIRA; TUP1-like enhancer of split protein 1", "protein_names_refseq": "TUP1-like enhancer of split gene 1; TUP1-like enhancer of split protein 1; histone cell cycle regulation defective homolog A; protein HIRA", "tax_id": 10090, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (mmu:15260); (R-MMU-2559584)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "11238922;15922569;16399082;21750661;25428506;30084848;31219806;34428180;35820727;37227756;39390295;40885482;40997131;8111380;8611624;9063745;9731536", "class_list": "", "function": "Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus. Publication Status: Online-Only, [RefSeq, PubMed]; Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08845;Q3TFY0;Q3UX35;Q62365;Q7TMW4", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016605 PML body;GO:0000785 chromatin;GO:0032991 protein-containing complex;GO:0000417 HIR complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006334 nucleosome assembly;GO:0001649 osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q61666-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q673U1-1", "uniprot_id": "HS3S2_MOUSE", "mass": 41378.0, "length": 367, "protein_name": "Heparan sulfate glucosamine 3-O-sulfotransferase 2", "gene_name": "Hs3st2", "organism": "Mouse", "refseq_name": "heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform 1", "refseq_ac": "NP_001074796", "gene_names_uniprotkb": "Hs3st2; 3ost2", "gene_names_refseq": "6430516N12Rik; A830061E14Rik; Hs3st2", "protein_names_uniprotkb": "Heparan sulfate glucosamine 3-O-sulfotransferase 2; 2.8.2.29; Heparan sulfate 3-O-sulfotransferase 2; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2", "protein_names_refseq": "heparan sulfate 3-O-sulfotransferase 2; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2; heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform 1", "tax_id": 10090, "disease": "lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:195646); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;36423858", "class_list": "glycogene", "function": "MicroRNA-100 shuttled by human umbilical cord MSC-secreted extracellular vesicles induces endometriosis by inhibiting HS3ST2., [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (By similarity). Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS (By similarity). Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLP1;Q8C055", "ec_number_list": "2.8.2.-;2.8.2.23;2.8.2.29;2.8.2.30", "go_molecular_function": "GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0007623 circadian rhythm;GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q673U1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q75VT8-1", "uniprot_id": "HIDE1_MOUSE", "mass": 23594.0, "length": 222, "protein_name": "Protein HIDE1", "gene_name": "AB124611; Hide1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AB124611; Hide1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein HIDE1; Highly expressed in immature dendritic cell transcript 1 protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:382062)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19144319;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q75VT7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q75VT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BM72-1", "uniprot_id": "HSP13_MOUSE", "mass": 51709.0, "length": 471, "protein_name": "Heat shock 70 kDa protein 13", "gene_name": "Hspa13", "organism": "Mouse", "refseq_name": "heat shock 70 kDa protein 13 precursor", "refseq_ac": "NP_084477", "gene_names_uniprotkb": "Hspa13; Stch", "gene_names_refseq": "1600002I10Rik; B230217N24Rik; Hspa13; Stch", "protein_names_uniprotkb": "Heat shock 70 kDa protein 13; Microsomal stress-70 protein ATPase core; Stress-70 protein chaperone microsome-associated 60 kDa protein", "protein_names_refseq": "heat shock 70 kDa protein 13 precursor; heat shock 70 kDa protein 13; heat shock protein 70 family, member 13; heat shock protein 70kDa family, member 13; microsomal stress-70 protein ATPase core; stress 70 protein chaperone, microsome-associated, 60kD human homolog; stress 70 protein chaperone, microsome-associated, human homolog; stress-70 protein chaperone microsome-associated 60 kDa protein", "tax_id": 10090, "disease": "congenital disorder of glycosylation type II (Disease Ontology:DOID:0050571); congenital disorder of glycosylation type IIc (Disease Ontology:DOID:0070255)", "pathway": " (mmu:110920); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22869728;26740625;28011936;30899004;32547538;34837777;37828378;40021952", "class_list": "", "function": "Has peptide-independent ATPase activity., [UniProtKB]; Hspa13 (Stch) gene has a role in prion disease incubation time in mice, [RefSeq, PubMed]; Hspa13 Promotes Plasma Cell Production and Antibody Secretion. Publication Status: Online-Only, [RefSeq, PubMed]; Single-cell atlas of splenocytes reveals a critical role of a novel plasma cellspecific marker Hspa13 in antibody class-switching recombination and somatic hypermutation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TII6;Q9D1X5", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8BM72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMT9-1", "uniprot_id": "HHAT_MOUSE", "mass": 57864.0, "length": 499, "protein_name": "Protein-cysteine N-palmitoyltransferase HHAT", "gene_name": "Hhat", "organism": "Mouse", "refseq_name": "protein-cysteine N-palmitoyltransferase HHAT", "refseq_ac": "NP_659130", "gene_names_uniprotkb": "Hhat; Skn", "gene_names_refseq": "2810432O22Rik; AP-2CRE; Hhat; Skn; Tg(TFAP2A-cre)1Will", "protein_names_uniprotkb": "Protein-cysteine N-palmitoyltransferase HHAT; 2.3.1.-; Hedgehog acyltransferase; Skinny hedgehog protein", "protein_names_refseq": "protein-cysteine N-palmitoyltransferase HHAT; skinny hedgehog protein", "tax_id": 10090, "disease": "chondrodysplasia-pseudohermaphroditism syndrome (Disease Ontology:DOID:0060644)", "pathway": " (mmu:226861); (R-MMU-5358346)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15075292;18081866;21750661;23112049;24784881;25488661;31875564", "class_list": "", "function": "Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane., [RefSeq, PubMed]; Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of hedgehog (DHH, IHH or SHH) morphogens, promoting their maturation (PubMed:15075292, PubMed:23112049, PubMed:25488661). Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where hedgehog palmitoylation occurs (PubMed:23112049). Required for hedgehog signaling during limb development (PubMed:15075292). Plays a role in proper testis cord formation and the differentiation of Leydig cells (PubMed:24784881)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ANS0;Q3TA33;Q922G3", "ec_number_list": "3.1.-.-;2.3.1.-", "go_molecular_function": "GO:0005525 GTP binding;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007224 smoothened signaling pathway;GO:0018345 protein palmitoylation;GO:0018009 N-terminal peptidyl-L-cysteine N-palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BMT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSL4-1", "uniprot_id": "HS3S5_MOUSE", "mass": 40471.0, "length": 346, "protein_name": "Heparan sulfate glucosamine 3-O-sulfotransferase 5", "gene_name": "Hs3st5", "organism": "Mouse", "refseq_name": "heparan sulfate glucosamine 3-O-sulfotransferase 5", "refseq_ac": "NP_001074677", "gene_names_uniprotkb": "Hs3st5; Hs3ost5", "gene_names_refseq": "D930005L05Rik; Gm1151; Hs3ost5; Hs3st5", "protein_names_uniprotkb": "Heparan sulfate glucosamine 3-O-sulfotransferase 5; 2.8.2.23; Heparan sulfate 3-O-sulfotransferase 5; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5", "protein_names_refseq": "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5; heparan sulfate glucosamine 3-O-sulfotransferase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:319415); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "31219806;36210013", "class_list": "glycogene", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2 (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.23;2.8.2.29;2.8.2.30", "go_molecular_function": "GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0046596 regulation of viral entry into host cell;GO:0006477 protein sulfation;GO:0050819 negative regulation of coagulation;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BSL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZS7-1", "uniprot_id": "HMGC2_MOUSE", "mass": 36650.0, "length": 343, "protein_name": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic", "gene_name": "Hmgcll1", "organism": "Mouse", "refseq_name": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic isoform 1", "refseq_ac": "NP_776092", "gene_names_uniprotkb": "Hmgcll1", "gene_names_refseq": "Hmgcll1", "protein_names_uniprotkb": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; 4.1.3.4", "protein_names_refseq": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic isoform 1; 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1; probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2", "tax_id": 10090, "disease": "amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:208982); (R-MMU-77111)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "Non-mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.3.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004419 hydroxymethylglutaryl-CoA lyase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046951 ketone body biosynthetic process;GO:0006552 L-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JZS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0U4-1", "uniprot_id": "HS12A_MOUSE", "mass": 74871.0, "length": 675, "protein_name": "Heat shock 70 kDa protein 12A", "gene_name": "Hspa12a", "organism": "Mouse", "refseq_name": "heat shock 70 kDa protein 12A isoform 1", "refseq_ac": "NP_001314927", "gene_names_uniprotkb": "Hspa12a; Kiaa0417", "gene_names_refseq": "1700063D12Rik; D5Mgi40; Gm19925; Hspa12a; mKIAA0417", "protein_names_uniprotkb": "Heat shock 70 kDa protein 12A", "protein_names_refseq": "heat shock 70 kDa protein 12A isoform 1; heat shock 70 kDa protein 12A; heat shock 70kDa protein 12A; heat shock protein 12A", "tax_id": 10090, "disease": "", "pathway": " (mmu:73442); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "12552099;21750661;22517741;22645316;28657654;30084848;30679749;32848054;33300544;34428180;34678516;35783189;37580315;38421727;38485044;40021952;40885482", "class_list": "", "function": "Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization., [UniProtKB, UniProtKB]; HSPA12A Stimulates p38/ERK-AP-1 Signaling to Promote Angiogenesis and Is Required for Functional Recovery Postmyocardial Infarction. Publication Status: Online-Only, [RefSeq, PubMed]; HSPA12A and HSPA12B may play roles in genetic susceptibility to atherosclerosis, [RefSeq, PubMed]; HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization. Publication Status: Online-Only, [RefSeq, PubMed]; HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; Roles of heat shock protein A12A in the development of diabetic cardiomyopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQZ8;Q8CHF6", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001889 liver development;GO:0006954 inflammatory response;GO:0051170 import into nucleus;GO:0042116 macrophage activation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8K0U4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K248-1", "uniprot_id": "HPDL_MOUSE", "mass": 39909.0, "length": 371, "protein_name": "4-hydroxyphenylpyruvate dioxygenase-like protein", "gene_name": "Hpdl", "organism": "Mouse", "refseq_name": "4-hydroxyphenylpyruvate dioxygenase-like protein", "refseq_ac": "NP_666368", "gene_names_uniprotkb": "Hpdl; Gloxd1", "gene_names_refseq": "A830048M07Rik; Gloxd1; Hpdl", "protein_names_uniprotkb": "4-hydroxyphenylpyruvate dioxygenase-like protein; 1.13.11.46; Glyoxalase domain-containing protein 1; HPDL", "protein_names_refseq": "4-hydroxyphenylpyruvate dioxygenase-like protein; glyoxalase domain containing 1; glyoxalase domain-containing protein 1", "tax_id": 10090, "disease": "hereditary spastic paraplegia 83 (Disease Ontology:DOID:0112346); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:242642); (R-MMU-2142789)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25428506;31219806", "class_list": "", "function": "Iron-dependent dioxygenase that catalyzes the conversion of 4-hydroxyphenylpyruvate (4-HPPA) to 4-hydroxymandelate (4-HMA) in the mitochondria, one of the steps in the biosynthesis of coenzyme Q10 from tyrosine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.13.11.46", "go_molecular_function": "GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity;GO:0046872 metal ion binding;GO:0050585 4-hydroxymandelate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009072 aromatic amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K248-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3X4-1", "uniprot_id": "I2BPL_MOUSE", "mass": 80565.0, "length": 775, "protein_name": "Probable E3 ubiquitin-protein ligase IRF2BPL", "gene_name": "Irf2bpl", "organism": "Mouse", "refseq_name": "probable E3 ubiquitin-protein ligase IRF2BPL", "refseq_ac": "NP_665835", "gene_names_uniprotkb": "Irf2bpl; Eap1; Kiaa1865", "gene_names_refseq": "6430527G18Rik; Eap1; Irf2bpl", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase IRF2BPL; 2.3.2.27; Enhanced at puberty protein 1; Interferon regulatory factor 2-binding protein-like", "protein_names_refseq": "enhanced at puberty protein 1; polyglutamine-containing protein; probable E3 ubiquitin-protein ligase IRF2BPL", "tax_id": 10090, "disease": "neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures (Disease Ontology:DOID:0081327); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (mmu:238330)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15345747;17242355;19144319;21183079;22517741;22645316;30084848;32782141;35820727;36852467;40885482;40997131", "class_list": "", "function": "Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBU9;Q3U483;Q3USE5;Q69Z84;Q8BUS1;Q8C011", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0046543 development of secondary female sexual characteristics;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8K3X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3Y8-1", "uniprot_id": "I2BP1_MOUSE", "mass": 61751.0, "length": 584, "protein_name": "Interferon regulatory factor 2-binding protein 1", "gene_name": "Irf2bp1", "organism": "Mouse", "refseq_name": "interferon regulatory factor 2-binding protein 1", "refseq_ac": "NP_848872", "gene_names_uniprotkb": "Irf2bp1", "gene_names_refseq": "6330414O09Rik; C530033F24; Irf2bp1", "protein_names_uniprotkb": "Interferon regulatory factor 2-binding protein 1; 2.3.2.27; IRF-2-binding protein 1; IRF-2BP1; Probable E3 ubiquitin-protein ligase IRF2BP1; Probable RING-type E3 ubiquitin transferase IRF2BP1", "protein_names_refseq": "IRF-2-binding protein 1; IRF-2BP1; interferon regulatory factor 2-binding protein 1; probable E3 ubiquitin-protein ligase IRF2BP1; probable RING-type E3 ubiquitin transferase IRF2BP1", "tax_id": 10090, "disease": "neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures (Disease Ontology:DOID:0081327); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (mmu:272359)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17242355;19131326;21183079", "class_list": "", "function": "Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJC9;Q8C0B1;Q8CI76", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R3Y8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921F4-1", "uniprot_id": "HNRLL_MOUSE", "mass": 64125.0, "length": 591, "protein_name": "Heterogeneous nuclear ribonucleoprotein L-like", "gene_name": "Hnrnpll", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein L-like", "refseq_ac": "NP_659051", "gene_names_uniprotkb": "Hnrnpll; Hnrpll", "gene_names_refseq": "2510028H02Rik; 2810036L13Rik; Hnrnpll; Hnrpll", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein L-like", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein L-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:72692)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;19100700;20505149;21183079;21750661;22073166;25428506;28135057;28360095;28528544;28611064;33152455;33331104;34428180;35820727;37507081", "class_list": "", "function": "A single substitution in a memory-induced RNA-binding protein, hnRNPLL, destabilized an RNA-recognition domain that bound with micromolar affinity to RNA containing the Ptprc exon-silencing sequence., [RefSeq, PubMed]; Behavioural phenotyping of thunder mice with a hypomorphic mutation of heterogeneous nuclear ribonuclear protein L-like (hnRNPLL) and reduced T cell function., [RefSeq, PubMed]; Data suggest that hnRNPLL specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL = heterogeneous nuclear ribonucleoprotein L-like protein; PABPC1 = cytoplasmic poly[A]-binding protein 1), [RefSeq, PubMed]; HNRNPLL is a novel metastasis suppressor of colorectal cancer, and modulates alternative splicing of CD44 during epithelial-mesenchymal transition., [RefSeq, PubMed]; In T cells with no CD45 protein, hnRNPLL mutation diminishes peripheral T cell accumulation and demonstrates that hnRNPLL regulates T cell longevity independently from its effects on CD45 splicing., [RefSeq, PubMed]; Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell development, activation and terminal differentiation into antibody-secreting cells., [RefSeq, PubMed]; RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC., [UniProtKB, PubMed]; Results highlight both overlapping and divergent roles for hnRNPLL between conventional T cells and NKT cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIK6;Q6IR44;Q8BIP6;Q91W02;Q99J40", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0045202 synapse;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0006397 mRNA processing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q921F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KG7-1", "uniprot_id": "HPS4_MOUSE", "mass": 72662.0, "length": 671, "protein_name": "BLOC-3 complex member HPS4", "gene_name": "Hps4", "organism": "Mouse", "refseq_name": "BLOC-3 complex member HPS4", "refseq_ac": "NP_619587", "gene_names_uniprotkb": "Hps4; Le", "gene_names_refseq": "2010205O06Rik; BLOC-3; C130020P05Rik; Hps4; le; mKIAA1667", "protein_names_uniprotkb": "BLOC-3 complex member HPS4; Hermansky-Pudlak syndrome 4 protein homolog; Le protein; Light-ear protein", "protein_names_refseq": "BLOC-3 complex member HPS4; Hermansky-Pudlak syndrome 4 homolog; hermansky-Pudlak syndrome 4 protein homolog; light ear; light-ear protein", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome 4 (Disease Ontology:DOID:0060542); platelet storage pool deficiency (Disease Ontology:DOID:2223); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:192232); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11836498;20048159;25428506;26620560;33392103;34428180", "class_list": "", "function": "Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38., [UniProtKB, UniProtKB]; VARP and Rab9 Are Dispensable for the Rab32/BLOC-3 Dependent Salmonella Killing. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0031085 BLOC-3 complex;GO:0042827 platelet dense granule;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:1903232 melanosome assembly;GO:0006605 protein targeting;GO:0007596 blood coagulation;GO:0050821 protein stabilization;GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99KG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6B9-1", "uniprot_id": "HRCT1_MOUSE", "mass": 13009.0, "length": 109, "protein_name": "Histidine-rich carboxyl terminus protein 1", "gene_name": "Hrct1", "organism": "Mouse", "refseq_name": "histidine-rich carboxyl terminus protein 1", "refseq_ac": "NP_081787", "gene_names_uniprotkb": "Hrct1", "gene_names_refseq": "3830408D24Rik; Hrct1", "protein_names_uniprotkb": "Histidine-rich carboxyl terminus protein 1", "protein_names_refseq": "histidine-rich carboxyl terminus protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039781)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANK5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D6B9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBA8-1", "uniprot_id": "HUTI_MOUSE", "mass": 46489.0, "length": 426, "protein_name": "Probable imidazolonepropionase", "gene_name": "Amdhd1", "organism": "Mouse", "refseq_name": "probable imidazolonepropionase", "refseq_ac": "NP_082184", "gene_names_uniprotkb": "Amdhd1", "gene_names_refseq": "1300019J08Rik; Amdhd1", "protein_names_uniprotkb": "Probable imidazolonepropionase; 3.5.2.7; Amidohydrolase domain-containing protein 1", "protein_names_refseq": "amidohydrolase domain-containing protein 1; probable imidazolonepropionase", "tax_id": 10090, "disease": "", "pathway": " (mmu:71761); (R-MMU-70921)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25428506;37453647", "class_list": "", "function": "Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to form N-formimidoyl-L-glutamate. This reaction represents the third step of the universal histidine degradation pathway. In addition to its metabolic role, functions as a tumor suppressor by promoting TGF-beta signaling. Mechanistically, inhibits ubiquitination and proteasomal degradation of SMAD4, thereby stabilizing the protein. Enhances SMAD2/3 phosphorylation and increases TGF-beta-dependent transcriptional responses. Consequently, promotes apoptosis and induces cell cycle arrest in tumor cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPP5;Q811K3;Q8R230", "ec_number_list": "3.5.2.7", "go_molecular_function": "GO:0046872 metal ion binding;GO:0050480 imidazolonepropionase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate;GO:0006548 L-histidine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DBA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCB1-1", "uniprot_id": "HMGN3_MOUSE", "mass": 10769.0, "length": 99, "protein_name": "High mobility group nucleosome-binding domain-containing protein 3", "gene_name": "Hmgn3", "organism": "Mouse", "refseq_name": "high mobility group nucleosome-binding domain-containing protein 3 isoform Hmgn3a", "refseq_ac": "NP_080398", "gene_names_uniprotkb": "Hmgn3", "gene_names_refseq": "1110002A15Rik; 6330514M13Rik; Hmgn3; TRIP7", "protein_names_uniprotkb": "High mobility group nucleosome-binding domain-containing protein 3", "protein_names_refseq": "high mobility group nucleosome-binding domain-containing protein 3 isoform Hmgn3a; high mobility group nucleosome-binding domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:94353)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11356838;12185205;15082770;18502697;19651901;19885867;21183079;21750661;23620591;26112184;35354046;37828378", "class_list": "", "function": "Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Hmgn3 may play an important role during mouse decidualization., [RefSeq, PubMed]; Phenotypic analysis of Hmgn1(tm1/tm1), Hmgn3(tm1/tm1), and Hmgn5(tm1/tm1) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities., [RefSeq, PubMed]; Results suggest that HMGN3 regulates glycine transporter 1 expression and demonstrate that members of the HMGN family can regulate the transcription of specific genes, [RefSeq, PubMed]; Rif1 and Hmgn3 regulate the conversion of murine trophoblast stem cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7M737;Q99JU1", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9DCB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DD02-1", "uniprot_id": "HIKES_MOUSE", "mass": 21619.0, "length": 197, "protein_name": "Protein Hikeshi", "gene_name": "Hikeshi", "organism": "Mouse", "refseq_name": "protein Hikeshi isoform b", "refseq_ac": "NP_001278215", "gene_names_uniprotkb": "Hikeshi; L7rn6", "gene_names_refseq": "0610007P06Rik; 1110002N09Rik; Hikeshi; l(7)6Rn; l7Rn6", "protein_names_uniprotkb": "Protein Hikeshi; Lethal gene on chromosome 7 Rinchik 6 protein", "protein_names_refseq": "lethal gene on chromosome 7 Rinchik 6 protein; protein Hikeshi isoform b; protein Hikeshi", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 13 (Disease Ontology:DOID:0060795)", "pathway": " (mmu:67669); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16157679;21750661;24582811;26545878;37865085", "class_list": "", "function": "Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination., [RefSeq, PubMed]; Study identified downregulation of let-7 as an upstream mechanism for IGF1/IGF1R upregulation and activation of ERK1/2 and PI3K as a downstream mechanism mediating the IGF1 signaling cascade promoting spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3YUY2;Q30C40;Q9CZT7", "ec_number_list": "", "go_molecular_function": "GO:0030544 Hsp70 protein binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0015031 protein transport;GO:0030324 lung development;GO:0034605 cellular response to heat;GO:0007030 Golgi organization;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DD02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL35-1", "uniprot_id": "HMGN5_MOUSE", "mass": 45344.0, "length": 406, "protein_name": "High mobility group nucleosome-binding domain-containing protein 5", "gene_name": "Hmgn5", "organism": "Mouse", "refseq_name": "high mobility group nucleosome-binding domain-containing protein 5", "refseq_ac": "NP_057919", "gene_names_uniprotkb": "Hmgn5; Garp45; Nsbp1", "gene_names_refseq": "GARP45; Hmgn5; NBP-45; Nsbp1", "protein_names_uniprotkb": "High mobility group nucleosome-binding domain-containing protein 5; NBP-45; Nucleosome-binding protein 1; Nucleosome-binding protein 45; Protein GARP45", "protein_names_refseq": "high mobility group nucleosome-binding domain-containing protein 5; nucleosome binding protein 1; nucleosome binding protein 45", "tax_id": 10090, "disease": "", "pathway": " (mmu:50887)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10692437;19160411;19748358;25609380;25825524;27579887;32315283;36066963", "class_list": "", "function": "HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis., [RefSeq, PubMed]; HMGN5 overexpression induces neurite outgrowth., [RefSeq, PubMed]; HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27., [RefSeq, PubMed]; Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2., [RefSeq, PubMed]; Mice overexpressing HMGN5, either globally or only in the heart, are normal at birth but develop hypertrophic heart with large cardiomyoctyes, deformed nuclei and disrupted lamina, and die of cardiac malfunction. Publication Status: Online-Only, [RefSeq, PubMed]; NSBP1 is an architectural protein that binds preferentially to euchromatin and modulates the fidelity of the cellular transcription profile by counteracting the chromatin-condensing activity of linker histones., [RefSeq, PubMed]; Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88832;Q3V272;Q8VC71;Q9CUW1", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JL35-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLS0-1", "uniprot_id": "HLPDA_MOUSE", "mass": 7007.0, "length": 64, "protein_name": "Hypoxia-inducible lipid droplet-associated protein", "gene_name": "Hilpda", "organism": "Mouse", "refseq_name": "hypoxia-inducible lipid droplet-associated protein isoform 2", "refseq_ac": "NP_076005", "gene_names_uniprotkb": "Hilpda; Hig2", "gene_names_refseq": "2310016C08Rik; Hig2; Hilpda", "protein_names_uniprotkb": "Hypoxia-inducible lipid droplet-associated protein; Hypoxia-inducible gene 2 protein", "protein_names_refseq": "hypoxia-inducible gene 2 protein; hypoxia-inducible lipid droplet-associated protein isoform 2; hypoxia-inducible lipid droplet-associated protein", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:69573); (R-MMU-8964572)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20624928;24876382;27900258;36990128;37061197", "class_list": "", "function": "Authors conclude that Hig2 localizes to LDs in adipocytes, promoting adipose tissue lipid deposition and that its selective deficiency in active brown/beige adipose tissue mediates improved glucose tolerance at 23 degrees C. Publication Status: Online-Only, [RefSeq, PubMed]; Data uncover HILPDA as a novel PPAR target that raises hepatic triglyceride storage via regulation of triglyceride secretion., [RefSeq, PubMed]; Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis., [RefSeq, PubMed]; HIG2 was up-regulated by hypoxia and HIF inducers in all cell types and mouse organs investigated and abundantly expressed in renal clear-cell carcinomas, [RefSeq, PubMed]; HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia., [RefSeq, PubMed]; Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMU3;Q8VDY1", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005811 lipid droplet;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0010884 positive regulation of lipid storage;GO:0071456 cellular response to hypoxia;GO:0001819 positive regulation of cytokine production;GO:0035425 autocrine signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JLS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUP5-1", "uniprot_id": "HPLN1_MOUSE", "mass": 40478.0, "length": 356, "protein_name": "Hyaluronan and proteoglycan link protein 1", "gene_name": "Hapln1", "organism": "Mouse", "refseq_name": "hyaluronan and proteoglycan link protein 1 precursor", "refseq_ac": "NP_038528", "gene_names_uniprotkb": "Hapln1; Crtl1", "gene_names_refseq": "CLP; Crtl1l; Crtl1; Hapln1; LP-1; LP", "protein_names_uniprotkb": "Hyaluronan and proteoglycan link protein 1; Cartilage-link protein; Cartilage-linking protein 1; Proteoglycan link protein", "protein_names_refseq": "cartilage link protein 1; cartilage-link protein; cartilage-linking protein 1; hyaluronan and proteoglycan link protein 1 precursor; proteoglycan link protein", "tax_id": 10090, "disease": "spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789)", "pathway": " (mmu:12950); (R-MMU-3000178)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10640815;12732630;30084848;30899004;33300544;38472454;38673852", "class_list": "glycogene", "function": "Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma., [RefSeq, PubMed]; Link Protein 1 Is Involved in the Activity-Dependent Modulation of Perineuronal Nets in the Spinal Cord. Publication Status: Online-Only, [RefSeq, PubMed]; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1G9;Q9Z1X7", "ec_number_list": "", "go_molecular_function": "GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0045202 synapse;GO:0072534 perineuronal net;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9QUP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ57-1", "uniprot_id": "HSPB3_MOUSE", "mass": 17230.0, "length": 154, "protein_name": "Heat shock protein beta-3", "gene_name": "Hspb3", "organism": "Mouse", "refseq_name": "heat shock protein beta-3", "refseq_ac": "NP_064344", "gene_names_uniprotkb": "Hspb3", "gene_names_refseq": "2310035K17Rik; Hsbp3; Hspb3; spb3", "protein_names_uniprotkb": "Heat shock protein beta-3; HspB3", "protein_names_refseq": "heat shock 27kD protein 3; heat shock protein 3; heat shock protein beta-3; small heat shock protein B3", "tax_id": 10090, "disease": "autosomal dominant distal hereditary motor neuronopathy 4 (Disease Ontology:DOID:0111209)", "pathway": " (mmu:56534)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21162133;27567740", "class_list": "", "function": "Inhibitor of actin polymerization., [UniProtKB]; It was suggested that a high predisposition to catalepsy in mice can be defined by the Map3k1, Il6st, Gzmk, and Hspb3 genes' coexpression network., [RefSeq, PubMed]; This study demonstrated that the endogenous HSPB3 protein distribution in the spinal cords of chicken and mouse embryos and in the postnatal nervous system (central and peripheral) of chicken, mouse and human., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q569N3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZ57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R118-1", "uniprot_id": "HTRA1_MOUSE", "mass": 51214.0, "length": 480, "protein_name": "Serine protease HTRA1", "gene_name": "Htra1", "organism": "Mouse", "refseq_name": "serine protease HTRA1 precursor", "refseq_ac": "NP_062510", "gene_names_uniprotkb": "Htra1; Htra; Prss11", "gene_names_refseq": "HTRA; Htra1; L56; Prss11; RSPP11", "protein_names_uniprotkb": "Serine protease HTRA1; 3.4.21.-; High-temperature requirement A serine peptidase 1; Serine protease 11", "protein_names_refseq": "high-temperature requirement A serine peptidase 1; insulin-like growth factor binding protein 5 protease; protease, serine, 11 (Igf binding); serine protease 11; serine protease HTRA1 precursor; serine protease HTRA1", "tax_id": 10090, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); patterned macular dystrophy (Disease Ontology:DOID:0060863); autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0061228); age related macular degeneration 7 (Disease Ontology:DOID:0110019); autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0111036); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); age related macular degeneration (Disease Ontology:DOID:10871); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); esophageal carcinoma (Disease Ontology:DOID:1107); Parkinson's disease (Disease Ontology:DOID:14330); malignant mesothelioma (Disease Ontology:DOID:1790); colon cancer (Disease Ontology:DOID:219); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:56213); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14973287;15101818;15206957;15993670;18551132;22049084;25428506;34428180;36715607;38515161;39013852", "class_list": "", "function": "During embryo development, HtrA1 was expressed in specific areas where signaling by Tgfbeta family proteins plays important regulatory roles, [RefSeq, PubMed]; HTRA1-driven detachment of type I collagen from endoplasmic reticulum contributes to myocardial fibrosis in dilated cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]; HtrA1 and HtrA3 show similar expression patterns and share the same inhibitory activity on TGF-beta signaling, [RefSeq, PubMed]; Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice., [RefSeq, PubMed]; Rational correction of pathogenic conformational defects in HTRA1. Publication Status: Online-Only, [RefSeq, PubMed]; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves (PubMed:18551132) or not (PubMed:14973287). By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BN04;Q8BN05;Q91WS3;Q9QZK6", "ec_number_list": "3.4.21.-", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0019838 growth factor binding;GO:0042802 identical protein binding;GO:0008236 serine-type peptidase activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0060718 chorionic trophoblast cell differentiation;GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0001890 placenta development;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9R118-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUU6-1", "uniprot_id": "HNF4G_MOUSE", "mass": 45897.0, "length": 408, "protein_name": "Hepatocyte nuclear factor 4-gamma", "gene_name": "Hnf4g", "organism": "Mouse", "refseq_name": "hepatocyte nuclear factor 4-gamma isoform 2", "refseq_ac": "NP_038948", "gene_names_uniprotkb": "Hnf4g; Nr2a2", "gene_names_refseq": "Hnf4g; NR2A2", "protein_names_uniprotkb": "Hepatocyte nuclear factor 4-gamma; HNF-4-gamma; Nuclear receptor subfamily 2 group A member 2", "protein_names_refseq": "HNF-4-gamma; hepatocyte nuclear factor 4-gamma isoform 2; nuclear receptor subfamily 2 group A member 2", "tax_id": 10090, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); maturity-onset diabetes of the young type 1 (Disease Ontology:DOID:0111099); Fanconi syndrome (Disease Ontology:DOID:1062); alcohol use disorder (Disease Ontology:DOID:1574); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:30942); (R-MMU-383280)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10786614;16945327;21750661;22872234;30084848;36607591", "class_list": "", "function": "HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription., [RefSeq, PubMed]; HNF4g has a role in energy expenditure, locomotor activity during night time, and higher body weight, [RefSeq, PubMed]; Transcription factor. Has a lower transcription activation potential than HNF4-alpha (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0045171 intercellular bridge;GO:0005667 transcription regulator complex;GO:0072686 mitotic spindle", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WUU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A8E0Y8-1", "uniprot_id": "IGSF2_MOUSE", "mass": 114205.0, "length": 1033, "protein_name": "Immunoglobulin superfamily member 2", "gene_name": "Cd101", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily member 2 precursor", "refseq_ac": "NP_001161378", "gene_names_uniprotkb": "Cd101; Igsf2", "gene_names_refseq": "Cd101; EWI-101; Gm1016; Gm734; Igsf2", "protein_names_uniprotkb": "Immunoglobulin superfamily member 2; EWI-101; Glu-Trp-Ile EWI motif-containing protein 101; IgSF2", "protein_names_refseq": "EWI immunoglobulin subfamily member EWI-101; glu-Trp-Ile EWI motif-containing protein 101; immunoglobulin superfamily member 2 precursor; immunoglobulin superfamily, member 2; leukocyte surface protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:630146); (R-MMU-202433)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12765969;15850792;21613616;21613619;21750661;26813346;31199784;37251384", "class_list": "", "function": "A gene region (Idd10) previously shown to influence susceptibility to type 1 diabetes in the NOD mouse also influences an autoimmune disease involving a different tissue, the liver, which follows an infection with Novosphingobium aromaticivorans., [RefSeq, PubMed]; CD101 inhibits the expansion of colitogenic T cells., [RefSeq, PubMed]; Cd101, but not Fcgr1, is responsible for the Idd10 effect, [RefSeq, PubMed]; Further support is provided for the hypothesis that Cd101 is insulin-dependent diabetes susceptibility region 10 (Idd10); haplotype and expression analyses of novel Idd10 congenic strains are coupled to the development of a CD101 knockout mouse., [RefSeq, PubMed]; Induction of Siglec-F[hi]CD101[hi] eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection. Publication Status: Online-Only, [RefSeq, PubMed]; Of the eight genes found in the Idd10 region, the CD101 gene was selected as a candidate for Idd10 based on its function in humans and its polymorphism in the NOD strain of mice, [RefSeq, PubMed]; Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells (By similarity)., [UniProtKB]; Ur results connect the Cd101 haplotype-dependent protection from T1D to an anti-diabetogenic function of CD101-expressing Tregs and Gr1-positive myeloid cells and confirm the identity of Cd101 as Idd10. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A8E0Y9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0032868 response to insulin;GO:0043029 T cell homeostasis;GO:0030099 myeloid cell differentiation;GO:0002763 positive regulation of myeloid leukocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A8E0Y8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RY83-1", "uniprot_id": "HPSE2_MOUSE", "mass": 66685.0, "length": 592, "protein_name": "Inactive heparanase-2", "gene_name": "Hpse2", "organism": "Mouse", "refseq_name": "inactive heparanase-2 precursor", "refseq_ac": "NP_001074726", "gene_names_uniprotkb": "Hpse2; Hpa2", "gene_names_refseq": "Gm968; Hpa2; Hpse2", "protein_names_uniprotkb": "Inactive heparanase-2; Hpa2", "protein_names_refseq": "inactive heparanase-2 precursor; inactive heparanase-2", "tax_id": 10090, "disease": "urofacial syndrome (Disease Ontology:DOID:0050816)", "pathway": " (mmu:545291); (R-MMU-2024096)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "25510506;25605945;30885509", "class_list": "glycogene;glycosylhydrolase", "function": "Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) (By similarity)., [UniProtKB]; Deletion of Hpse2 cause the urofacial syndrome-like phenotype in mice., [RefSeq, PubMed]; Mice with homozygous mutations in either Lrig2 or Hpse2 had increased nerve density within the urinary bladder body and decreased nerve density around the urinary outflow tract. Observations provide evidence that a peripheral neuropathy is central to the pathobiology of functional bladder outlet obstruction in urofacial syndrome and emphasize the importance of LRIG2 and Hpse2 for nerve patterning in the urinary tract., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043395 heparan sulfate proteoglycan binding;GO:0016798 hydrolase activity, acting on glycosyl bonds", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B2RY83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D0VYS2-1", "uniprot_id": "HSF3_MOUSE", "mass": 57302.0, "length": 492, "protein_name": "Heat shock factor protein 3", "gene_name": "Hsf3", "organism": "Mouse", "refseq_name": "heat shock factor protein 3 isoform 3", "refseq_ac": "NP_001297684", "gene_names_uniprotkb": "Hsf3", "gene_names_refseq": "B230358A15Rik; HSF 3; HSTF 3; Hsf3", "protein_names_uniprotkb": "Heat shock factor protein 3; HSF 3; HSTF 3; Heat shock transcription factor 3; mHSF3", "protein_names_refseq": "heat shock factor protein 3 isoform 3; heat shock factor protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:245525)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19864465;21750661", "class_list": "", "function": "DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription of non-classical heat-shock genes such as PDZD2 and PROM2. Protects cells against heat shock and proteotoxic stress., [UniProtKB, PubMed]; MHSF3 represents a unique heat shock transcription factor that has the potential to activate only nonclassical heat-shock genes to protect cells from detrimental stresses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D0VYS3", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D0VYS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08528-1", "uniprot_id": "HXK2_MOUSE", "mass": 102535.0, "length": 917, "protein_name": "Hexokinase-2", "gene_name": "Hk2", "organism": "Mouse", "refseq_name": "hexokinase-2", "refseq_ac": "NP_038848", "gene_names_uniprotkb": "Hk2", "gene_names_refseq": "HKII; Hk2", "protein_names_uniprotkb": "Hexokinase-2; 2.7.1.1; HK II; Hexokinase type II", "protein_names_refseq": "HK II; hexokinase type II; hexokinase-2", "tax_id": 10090, "disease": "type 1 diabetes mellitus 2 (Disease Ontology:DOID:0110741); hypertension (Disease Ontology:DOID:10763); glucose metabolism disease (Disease Ontology:DOID:4194); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15277); (R-MMU-70171)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10428828;10656921;18350175;21750661;22645316;25605945;28315936;29985480;30084848;34428180;37507081;37828378;39627609;39927985", "class_list": "glycogene", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.1;2.7.1.-", "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0005524 ATP binding;GO:0004396 hexokinase activity;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0035795 negative regulation of mitochondrial membrane permeability;GO:0002931 response to ischemia;GO:0001666 response to hypoxia;GO:0045766 positive regulation of angiogenesis;GO:0046324 regulation of D-glucose import", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O08528-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QY40-1", "uniprot_id": "PLXB3_MOUSE", "mass": 208366.0, "length": 1902, "protein_name": "Plexin-B3", "gene_name": "Plxnb3", "organism": "Mouse", "refseq_name": "plexin-B3 precursor", "refseq_ac": "NP_062533", "gene_names_uniprotkb": "Plxnb3; Kiaa1206; Plxn6", "gene_names_refseq": "Plxn6; Plxnb3", "protein_names_uniprotkb": "Plexin-B3; Plexin-6", "protein_names_refseq": "plexin 6; plexin-B3 precursor", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:140571); (R-MMU-416700)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15147296;15218527;16122393;19699796;20696765;21706053;30899004;33300544;34428180", "class_list": "", "function": "Plexin-B3 is a functional receptor for semaphorin 5A, [RefSeq, PubMed]; Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 (By similarity). Seem to be non-essential for normal development and function of the central nervous system., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 6, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 2, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "A2AFF9;Q80TH8", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0017154 semaphorin receptor activity;GO:0098632 cell-cell adhesion mediator activity;GO:0051022 Rho GDP-dissociation inhibitor binding", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0010976 positive regulation of neuron projection development;GO:0071526 semaphorin-plexin signaling pathway;GO:0030336 negative regulation of cell migration;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9QY40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80U70-1", "uniprot_id": "SUZ12_MOUSE", "mass": 83026.0, "length": 741, "protein_name": "Polycomb protein Suz12", "gene_name": "Suz12", "organism": "Mouse", "refseq_name": "polycomb protein Suz12 isoform 2", "refseq_ac": "NP_001156490", "gene_names_uniprotkb": "Suz12; D11Ertd530e; Kiaa0160", "gene_names_refseq": "2610028O16Rik; D11Ertd530e; Suz12; mKIAA0160", "protein_names_uniprotkb": "Polycomb protein Suz12; Suppressor of zeste 12 protein homolog", "protein_names_refseq": "polycomb protein Suz12 isoform 2; polycomb protein Suz12; suppressor of zeste 12 homolog; suppressor of zeste 12 protein homolog", "tax_id": 10090, "disease": "spina bifida (Disease Ontology:DOID:0080016); renal Wilms' tumor (Disease Ontology:DOID:5176)", "pathway": " (mmu:52615); (R-MMU-212300); (R-MMU-2559580); (R-MMU-3214841); (R-MMU-4551638); (R-MMU-8943724); (R-MMU-8953750); (R-MMU-9764725); (R-MMU-9909649)", "pathway_count": 9, "publication_count": 17, "publication_id_list": "15385962;15516932;15684044;16415857;16712789;17339329;19026780;19144319;20144788;21183079;21750661;22226355;23970558;25428506;31219806;31914400;34428180", "class_list": "", "function": "Here we show that mice lacking Suz12, like Ezh2 and Eed mutant mice, are not viable and die during early postimplantation stages displaying severe developmental and proliferative defects., [RefSeq, PubMed]; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AQE5;Q80Y10;Q99L07", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016604 nuclear body;GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0021510 spinal cord development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80U70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51859-1", "uniprot_id": "HDGF_MOUSE", "mass": 26269.0, "length": 237, "protein_name": "Hepatoma-derived growth factor", "gene_name": "Hdgf", "organism": "Mouse", "refseq_name": "hepatoma-derived growth factor isoform 1", "refseq_ac": "NP_032257", "gene_names_uniprotkb": "Hdgf; Tdrm1", "gene_names_refseq": "D3Ertd299e; Hdgf", "protein_names_uniprotkb": "Hepatoma-derived growth factor; HDGF", "protein_names_refseq": "hepatoma-derived growth factor isoform 1; hepatoma-derived growth factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:15191)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11751870;12447878;14508832;15345747;17242355;17622165;18630941;19144319;21087088;21183079;21489262;21750661;22645316;25153642;28135057;28528544;34428180;36265285;37507081;37827291;9299445", "class_list": "", "function": "Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity)., [UniProtKB, UniProtKB]; HDGF stimulates liver tumorigenesis by enhancing reactive oxygen species generation in mitochondria., [RefSeq, PubMed]; Hepatoma-derived growth factor helps regulate the hepatocyte proliferation in liver development., [RefSeq, PubMed]; Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus, [RefSeq, PubMed]; Increased HDGF expression is correlated with disease progression of hepatocellular carcinoma and represent a specific prognostic factor in patient with liver cancer., [RefSeq, PubMed]; RNA-m6A modification of HDGF mediated by Mettl3 aggravates the progression of atherosclerosis by regulating macrophages polarization via energy metabolism reprogramming., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPG7;Q9CYA4;Q9JK87", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008201 heparin binding;GO:0000166 nucleotide binding;GO:0003714 transcription corepressor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P51859-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64104-1", "uniprot_id": "NR2E1_MOUSE", "mass": 42619.0, "length": 385, "protein_name": "Nuclear receptor subfamily 2 group E member 1", "gene_name": "Nr2e1", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 2 group E member 1", "refseq_ac": "NP_689415", "gene_names_uniprotkb": "Nr2e1; Tll; Tlx", "gene_names_refseq": "Mtl1; Mtll; Nr2e1; TLL; Tlx; XTLL; fierce; frc; tailless", "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Protein tailless homolog; Tll; mTll", "protein_names_refseq": "nuclear receptor TLX; nuclear receptor subfamily 2 group E member 1; protein tailless homolog", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (mmu:21907); (R-MMU-383280)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10706625;11997145;16702404;17901127;36321378;36625299;40021952;7720587", "class_list": "", "function": "A NR2E1-interacting peptide of LSD1 inhibits the proliferation of brain tumour initiating cells., [RefSeq, PubMed]; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Regulates cell cycle progression in neural stem cells of rhe developing brain. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acid receptor (RAR) regulation in retinal cells., [UniProtKB, PubMed, PubMed, PubMed]; Tailless and hypoxia inducible factor-2alpha cooperate to sustain proangiogenic states of retinal astrocytes in neonatal mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64104-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPU0-1", "uniprot_id": "RENT1_MOUSE", "mass": 123967.0, "length": 1124, "protein_name": "Regulator of nonsense transcripts 1", "gene_name": "Upf1", "organism": "Mouse", "refseq_name": "regulator of nonsense transcripts 1 isoform a", "refseq_ac": "NP_001116301", "gene_names_uniprotkb": "Upf1; Rent1", "gene_names_refseq": "B430202H16Rik; NORF1; PNORF-1; Rent1; Upf1; Upflp", "protein_names_uniprotkb": "Regulator of nonsense transcripts 1; 5.6.2.3; 5.6.2.5; ATP-dependent helicase RENT1; Double-stranded nucleic acid 5'-3' helicase Upf1; NORF1; Nonsense mRNA reducing factor 1; Up-frameshift suppressor 1 homolog; mUpf1", "protein_names_refseq": "ATP-dependent helicase RENT1; UPF1 regulator of nonsense transcripts homolog; regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog); regulator of nonsense transcripts 1 isoform a", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:19704); (R-MMU-975956); (R-MMU-975957)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;11152657;17242355;18299400;19224205;20173027;21183079;21952136;22872234;25428506;25428507;25605945;26495903;27149095;30084848;30779550;31219806;32782141;34428180;34678516;35820727;36001654;36210013;36652050;37453647;37828378;38982067;39627609;8855285", "class_list": "", "function": "BMSC-Derived Exosomes Carrying lncRNA-ZFAS1 Alleviate Pulmonary Ischemia/Reperfusion Injury by UPF1-Mediated mRNA Decay of FOXD1., [RefSeq, PubMed]; RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (By similarity). Has ATP-dependent 5'-3' helicase active on RNA:DNA; RNA:RNA and DNA:DNA substrates with a 5'-extension (By similarity). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (By similarity). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (By similarity). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (By similarity). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (By similarity). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (By similarity). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (By similarity). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (By similarity). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (By similarity). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity) (PubMed:27149095)., [UniProtKB, UniProtKB, PubMed]; UPF1 plays critical roles in early B cell development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UG00;Q6GYP5;Q6PHQ5;Q8K0N4;Q99PR4", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.1.3.16;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;2.7.11.1;3.4.21.53;2.7.7.7;2.7.7.49;2.7.4.3;3.6.1.62", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0032201 telomere maintenance via semi-conservative replication;GO:0006449 regulation of translational termination;GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q9EPU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54864-1", "uniprot_id": "SUV91_MOUSE", "mass": 47754.0, "length": 412, "protein_name": "Histone-lysine N-methyltransferase SUV39H1", "gene_name": "Suv39h1", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase SUV39H1 isoform 2", "refseq_ac": "NP_001277645", "gene_names_uniprotkb": "Suv39h1; Suv39h", "gene_names_refseq": "DXHXS7466e; H3-K9-HMTase 1; KMT1A; Suv39h1; mIS6", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SUV39H1; 2.1.1.-; H3-K9-HMTase 1; Histone H3-K9 methyltransferase 1; Position-effect variegation 3-9 homolog; Su(var)3-9 homolog 1; Suppressor of variegation 3-9 homolog 1", "protein_names_refseq": "Suv39h histone methyltransferase; histone H3-K9 methyltransferase 1; histone-lysine N-methyltransferase SUV39H1 isoform 2; histone-lysine N-methyltransferase SUV39H1; position-effect variegation 3-9 homolog; su(var)3-9 homolog 1; suppressor of variegation 3-9 homolog 1", "tax_id": 10090, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071)", "pathway": " (mmu:20937); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10202156;10754099;10949293;11094092;11520670;11701123;11788710;12867029;14690609;14690610;14702045;17242355;18004385;18619962;21183079;21750661;22939622;23695662;24413057;24728993;30111536;31219806;34428180;38719473;38961301", "class_list": "", "function": "Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate (PubMed:10949293, PubMed:11701123, PubMed:14690609, PubMed:14690610, PubMed:18004385, PubMed:22939622, PubMed:30111536). Also weakly methylates histone H1 (in vitro) (By similarity). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones (PubMed:10949293). Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions (PubMed:14702045). H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats (PubMed:12867029). SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length (By similarity). Involved in the maintenance of H3K9me3 mark following DNA replication, when histone marks are diluted: HP1 recognizes the preexisting H3K9me3 mark and serves as a platform to recruit SUV39H1 to modify the adjacent newly incorporated histones (PubMed:10949293). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (By similarity). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (By similarity). Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (PubMed:24413057)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Role in co-regulating growth control and differentiation during mammalian development, [RefSeq, PubMed]; Suv39h-catalyzed H3K9me3 is critical for euchromatic genome organization and the maintenance of gene transcription. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEW2;Q3UT51;Q8C2L3;Q9JLC7;Q9JLP8", "ec_number_list": "2.1.1.-;2.1.1.366;2.1.1.367;2.1.1.364", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0008276 protein methyltransferase activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0005677 chromatin silencing complex", "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0040014 regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "O54864-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC85-1", "uniprot_id": "LSM1_MOUSE", "mass": 15236.0, "length": 133, "protein_name": "U6 snRNA-associated Sm-like protein LSm1", "gene_name": "Lsm1", "organism": "Mouse", "refseq_name": "U6 snRNA-associated Sm-like protein LSm1", "refseq_ac": "NP_080308", "gene_names_uniprotkb": "Lsm1", "gene_names_refseq": "2810025O06Rik; CASM; Lsm1", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm1", "protein_names_refseq": "LSM1 homolog, U6 small nuclear RNA associated; U6 snRNA-associated Sm-like protein LSm1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67207); (R-MMU-430039)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;25428506;25428507;25605945;27802388;30084848;30779550;34428180;35820727;39927985", "class_list": "", "function": "Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006397 mRNA processing;GO:0045665 negative regulation of neuron differentiation;GO:0008380 RNA splicing;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VC85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88952-1", "uniprot_id": "LIN7C_MOUSE", "mass": 21834.0, "length": 197, "protein_name": "Protein lin-7 homolog C", "gene_name": "Lin7c", "organism": "Mouse", "refseq_name": "protein lin-7 homolog C", "refseq_ac": "NP_035829", "gene_names_uniprotkb": "Lin7c; Mals3; Veli3", "gene_names_refseq": "9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C; Lin7c; MALS-3; Veli3", "protein_names_uniprotkb": "Protein lin-7 homolog C; Lin-7C; MALS-3; Mammalian lin-seven protein 3; Veli-3; Vertebrate lin-7 homolog 3; mLin7C", "protein_names_refseq": "lin 7 homolog c; lin-7 homolog C; mammalian lin-seven protein 3; protein lin-7 homolog C; vertebrate homolog of C. elegans Lin-7 type 3; vertebrate lin-7 homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:22343); (R-MMU-212676)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10341223;10710551;10753959;10846156;15466885;15494546;15878399;19726564;25428506;31219806;34428180;9753324", "class_list": "", "function": "Data show that CASK expression and the appropriate localization of DLG1 and LIN7c are not essential for either epithelial polarity or intestinal homeostasis in vivo., [RefSeq, PubMed]; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0008092 cytoskeletal protein binding;GO:0030165 PDZ domain binding;GO:0097016 L27 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0015031 protein transport;GO:0007269 neurotransmitter secretion;GO:0006887 exocytosis;GO:0002011 morphogenesis of an epithelial sheet;GO:0048489 synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O88952-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60762-1", "uniprot_id": "MO4L1_MOUSE", "mass": 41493.0, "length": 362, "protein_name": "Mortality factor 4-like protein 1", "gene_name": "Morf4l1", "organism": "Mouse", "refseq_name": "mortality factor 4-like protein 1 isoform a", "refseq_ac": "NP_001034236", "gene_names_uniprotkb": "Morf4l1; Mrg15; Tex189", "gene_names_refseq": "MORFRG15; MRG15; Morf4l1; TEG-189; Tex189; mKIAA4002", "protein_names_uniprotkb": "Mortality factor 4-like protein 1; MORF-related gene 15 protein; Testis-expressed gene 189 protein; Transcription factor-like protein MRG15", "protein_names_refseq": "MORF-related gene 15 protein; mortality factor 4-like protein 1 isoform a; mortality factor 4-like protein 1; testis expressed gene 189; testis-expressed gene 189 protein; transcription factor-like protein MRG15", "tax_id": 10090, "disease": "", "pathway": " (mmu:21761)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11290425;15367658;21750661;25428506;27573846;31219806;32694659;34428180;35985547;36210013", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci., [UniProtKB, UniProtKB]; In round spermatids, MRG15 colocalizes with splicing factors PTBP1 and PTBP2 at H3K36me3 sites between the exons and single intron of transition nuclear protein 2 (Tnp2). Thus, our results reveal that MRG15 is essential for pre-mRNA splicing during spermatogenesis and that epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorder, [RefSeq, PubMed]; MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM., [RefSeq, PubMed]; MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNY9;Q99MQ0", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0035267 NuA4 histone acetyltransferase complex;GO:0070822 Sin3-type complex;GO:0000786 nucleosome;GO:0005634 nucleus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0008283 cell population proliferation;GO:0045893 positive regulation of DNA-templated transcription;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P60762-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27811-1", "uniprot_id": "KLRBA_MOUSE", "mass": 25782.0, "length": 227, "protein_name": "Killer cell lectin-like receptor subfamily B member 1A", "gene_name": "Klrb1a", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor subfamily B member 1A isoform 2", "refseq_ac": "NP_001153374", "gene_names_uniprotkb": "Klrb1a; Ly55a; Ly55; Nkrp1a", "gene_names_refseq": "Klrb1a; Ly55a; NKR-P1.7; NKR-P1A; NKRP12; Nkrp1-a; Nkrp1a; ly-55A", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily B member 1A; CD161 antigen-like family member A; Ly-55A; Lymphocyte antigen 55A; NKR-P1 2; NKR-P1.7; NKR-P1A; Natural killer cell surface protein P1-2", "protein_names_refseq": "CD161 antigen-like family member A; NKR-P1 2; killer cell lectin-like receptor subfamily B member 1A isoform 2; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55A; natural killer cell receptor protein NKR-P1A; natural killer cell receptor-P1; natural killer cell surface protein P1-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17057); (R-MMU-198933)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10229823;11685472;1517565;16751398;1680927;1880421;21600988;21750661;27238500;30995786", "class_list": "glycogene", "function": "Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a stimulatory role on natural killer (NK) cell cytotoxicity., [UniProtKB, PubMed]; Solution structure of the lymphocyte receptor Nkrp1a reveals a distinct conformation of the long loop region as compared to in the crystal structure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1AG01;Q1WJB8;Q61972;Q61973;Q91V25;Q925G4", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042269 regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P27811-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXV3-1", "uniprot_id": "ING1_MOUSE", "mass": 32109.0, "length": 279, "protein_name": "Inhibitor of growth protein 1", "gene_name": "Ing1", "organism": "Mouse", "refseq_name": "inhibitor of growth protein 1 isoform 3", "refseq_ac": "NP_001289386", "gene_names_uniprotkb": "Ing1", "gene_names_refseq": "2610028J21Rik; Ing1; mING1h; p33Ing1; p37Ing1b", "protein_names_uniprotkb": "Inhibitor of growth protein 1", "protein_names_refseq": "inhibitor of growth protein 1 isoform 3; inhibitor of growth protein 1", "tax_id": 10090, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); carcinoma (Disease Ontology:DOID:305); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520)", "pathway": " (mmu:26356)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10542254;21750661;25428506;27305909;29158107;30084848;30779550;31219806;34418053", "class_list": "", "function": "ING1 knockdown leads to decreased expression of genes related to synaptic plasticity, including the regulatory subunit of calcineurin, Ppp3r1. In addition, ING1 binding at a site upstream of the transcription start site (TSS) of Ppp3r1 depends on yet another group of neuroepigenetic regulatory proteins, the Piwi-like family, which are also involved in DNA repair., [RefSeq, PubMed]; Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor., [UniProtKB, PubMed]; Taken together, our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RWH0;Q9QUP8;Q9QXV4;Q9QZX3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030336 negative regulation of cell migration;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QXV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AVY7-1", "uniprot_id": "KI16B_MOUSE", "mass": 150058.0, "length": 1312, "protein_name": "Kinesin-like protein KIF16B", "gene_name": "Kif16b", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF16B isoform 2", "refseq_ac": "NP_001074602", "gene_names_uniprotkb": "Kif16b; Kiaa1590", "gene_names_refseq": "8430434E15Rik; Kif16b; mKIAA1590", "protein_names_uniprotkb": "Kinesin-like protein KIF16B", "protein_names_refseq": "N-3 kinesin; kinesin 16B; kinesin-like protein KIF16B isoform 2; kinesin-like protein KIF16B", "tax_id": 10090, "disease": "", "pathway": " (mmu:16558); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "19144319;21183079;21238925;21750661;25810535;31219806;34428180;40021952;9275178", "class_list": "", "function": "Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development., [UniProtKB, PubMed]; The kinesin-3 motor KIF16B/Rab14 complex acts in biosynthetic Golgi-to-endosome traffic of the fibroblast growth factor receptor (FGFR) during early embryonic development., [RefSeq, PubMed]; The stalk domain of kinesin superfamily protein 16B determines the specific somatodendritic localization of Endosomes mediated by a novel intramolecular inhibitory mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35056;Q3TUD2;Q6ZPM0;Q8BZZ9", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008017 microtubule binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0001919 regulation of receptor recycling;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0045022 early endosome to late endosome transport;GO:0071346 cellular response to type II interferon;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "B1AVY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59325-1", "uniprot_id": "IF5_MOUSE", "mass": 48968.0, "length": 429, "protein_name": "Eukaryotic translation initiation factor 5", "gene_name": "Eif5", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 5", "refseq_ac": "NP_775539", "gene_names_uniprotkb": "Eif5", "gene_names_refseq": "2810011H21Rik; D12Ertd549e; Eif5", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5; eIF-5", "protein_names_refseq": "eIF-5; eukaryotic translation initiation factor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:217869); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17242355;21183079;21750661;34428180;37453647", "class_list": "", "function": "Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC. When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP. Start codon recognition also induces a conformational change of the PIC to a closed state. This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC. Finally, EIF5 stabilizes the PIC in its closed conformation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0071074 eukaryotic initiation factor eIF2 binding;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0003743 translation initiation factor activity;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0006446 regulation of translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0042255 ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P59325-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923T9-1", "uniprot_id": "KCC2G_MOUSE", "mass": 59607.0, "length": 529, "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit gamma", "gene_name": "Camk2g", "organism": "Mouse", "refseq_name": "calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2", "refseq_ac": "NP_001034227", "gene_names_uniprotkb": "Camk2g", "gene_names_refseq": "Camk2g; Camkg", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II subunit gamma; 2.7.11.17; CaM kinase II subunit gamma; CaMK-II subunit gamma", "protein_names_refseq": "Ca2+/calmodulin-dependent protein kinase II; CaMK II; caMK-II subunit gamma; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 59 (Disease Ontology:DOID:0061033); heart conduction disease (Disease Ontology:DOID:10273); malignant astrocytoma (Disease Ontology:DOID:3069)", "pathway": " (mmu:12325); (R-MMU-3371571); (R-MMU-399719); (R-MMU-438066); (R-MMU-5578775); (R-MMU-5673000); (R-MMU-5673001); (R-MMU-877300); (R-MMU-936837)", "pathway_count": 9, "publication_count": 16, "publication_id_list": "11972023;16452087;17114649;21183079;21750661;23516528;28528544;29371236;30184290;30862473;32887881;33300544;33525071;33707504;37828378;38597448", "class_list": "", "function": "Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (By similarity). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (By similarity). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning (PubMed:30184290). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023)., [UniProtKB, UniProtKB, PubMed]; [PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMKgamma and CaMKdelta against ischemic reperfusion injury in mice]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3H3;Q8VED3", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;3.2.1.31;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;7.2.2.10;2.7.11.10;2.7.11.11;2.7.10.1;2.7.11.26;2.7.11.19;2.7.11.17;3.6.5.2;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;3.1.3.48;2.3.2.27;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0043005 neuron projection;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:1901897 regulation of relaxation of cardiac muscle;GO:0006979 response to oxidative stress;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q923T9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YXS5-1", "uniprot_id": "KIF28_MOUSE", "mass": 114827.0, "length": 1028, "protein_name": "Kinesin-like protein KIF28", "gene_name": "Kif28", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Kif28; Gm1305; Klp6", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinesin-like protein KIF28; Kinesin family member 28; Kinesin-like protein 6", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0031966 mitochondrial membrane;GO:0005871 kinesin complex", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0072384 organelle transport along microtubule;GO:0047496 vesicle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3YXS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0T9-1", "uniprot_id": "ITB6_MOUSE", "mass": 86042.0, "length": 787, "protein_name": "Integrin beta-6", "gene_name": "Itgb6", "organism": "Mouse", "refseq_name": "integrin beta-6 precursor", "refseq_ac": "NP_001153036", "gene_names_uniprotkb": "Itgb6", "gene_names_refseq": "2210409C20Rik; 4831415H04Rik; Itgb6", "protein_names_uniprotkb": "Integrin beta-6", "protein_names_refseq": "integrin beta-6 precursor", "tax_id": 10090, "disease": "amelogenesis imperfecta type 1H (Disease Ontology:DOID:0110064); cancer (Disease Ontology:DOID:162); asthma (Disease Ontology:DOID:2841); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:16420); (R-MMU-1566948); (R-MMU-2129379); (R-MMU-216083); (R-MMU-2173789); (R-MMU-3000178)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10025398;11095652;21750661;33300544;36268721;38844455", "class_list": "", "function": "Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (PubMed:10025398). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398)., [UniProtKB, UniProtKB, PubMed]; Knockout of integrin alphavbeta6 protects against renal inflammation in chronic kidney disease by reduction of pro-inflammatory macrophages. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q544J9", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0015026 coreceptor activity;GO:0046872 metal ion binding;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0034685 integrin alphav-beta6 complex", "go_biological_process": "GO:0060435 bronchiole development;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z0T9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59438-1", "uniprot_id": "HPS5_MOUSE", "mass": 126337.0, "length": 1126, "protein_name": "BLOC-2 complex member HPS5", "gene_name": "Hps5", "organism": "Mouse", "refseq_name": "BLOC-2 complex member HPS5 isoform 1", "refseq_ac": "NP_001005247", "gene_names_uniprotkb": "Hps5; Ru2", "gene_names_refseq": "Hps5; haze; hz; maroon; mr; ru-2; ru2", "protein_names_uniprotkb": "BLOC-2 complex member HPS5; Hermansky-Pudlak syndrome 5 protein homolog; Ru2; Ruby-eye protein 2", "protein_names_refseq": "BLOC-2 complex member HPS5 isoform 1; BLOC-2 complex member HPS5; Hermansky-Pudlak syndrome 5 homolog; hermansky-Pudlak syndrome 5 protein homolog; ruby eye 2; ruby-eye protein 2", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome 5 (Disease Ontology:DOID:0060543); platelet storage pool deficiency (Disease Ontology:DOID:2223); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:246694)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12548288;19144319;21750661;23672590;27333462;31219806;34428180", "class_list": "", "function": "Effects of the ru2(d) allele on pheomelanin synthesis were investigated., [RefSeq, PubMed]; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nonsense Mutation in HPS5 gene is associated with hypopigmentation in colitis mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X8S7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0031084 BLOC-2 complex", "go_biological_process": "GO:1903232 melanosome assembly;GO:0007596 blood coagulation;GO:0060155 platelet dense granule organization;GO:0043473 pigmentation;GO:0048066 developmental pigmentation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P59438-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53657-1", "uniprot_id": "KPYR_MOUSE", "mass": 62309.0, "length": 574, "protein_name": "Pyruvate kinase PKLR", "gene_name": "Pklr", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pklr", "gene_names_refseq": "", "protein_names_uniprotkb": "Pyruvate kinase PKLR; 2.7.1.40; L-PK; Pyruvate kinase isozymes L/R", "protein_names_refseq": "", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital nonspherocytic hemolytic anemia 2 (Disease Ontology:DOID:0111077); malaria (Disease Ontology:DOID:12365); Gaucher's disease (Disease Ontology:DOID:1926); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18770); (R-MMU-70171); (R-MMU-70268)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21750661;30084848;34428180;35984892;37453647;7579416", "class_list": "", "function": "Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.2;2.7.11.1;2.7.1.40", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0030955 potassium ion binding;GO:0004743 pyruvate kinase activity", "go_cellular_component": "GO:1902912 pyruvate kinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0051707 response to other organism;GO:0032869 cellular response to insulin stimulus;GO:0006096 glycolytic process;GO:0051591 response to cAMP", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53657-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97411-1", "uniprot_id": "ICA69_MOUSE", "mass": 54324.0, "length": 478, "protein_name": "Islet cell autoantigen 1", "gene_name": "Ica1", "organism": "Mouse", "refseq_name": "islet cell autoantigen 1 isoform 2", "refseq_ac": "NP_001239195", "gene_names_uniprotkb": "Ica1; Icap69", "gene_names_refseq": "69kDa; ICA69; Ica1", "protein_names_uniprotkb": "Islet cell autoantigen 1; 69 kDa islet cell autoantigen; ICA69; ICAp69; Islet cell autoantigen p69; p69", "protein_names_refseq": "69 kDa islet cell autoantigen; ICAp69; islet cell autoantigen 1 isoform 2; islet cell autoantigen 1, 69 kDa; islet cell autoantigen p69; p69", "tax_id": 10090, "disease": "diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:15893)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11029035;11751995;21750661;27069933;32531799;34428180;38884369;8975715;9128175", "class_list": "", "function": "ICA1 affects APP processing through the PICK1-PKCalpha signaling pathway., [RefSeq, PubMed]; Islet-cell autoantigen 69 accelerates liver regeneration by downregulating Tgfbr1 and attenuating Tgfbeta signaling in mice., [RefSeq, PubMed]; May play a role in neurotransmitter secretion., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLS3;P97362;P97954;Q99M40;Q9R2C4", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0140090 membrane curvature sensor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0097753 membrane bending;GO:0046928 regulation of neurotransmitter secretion;GO:0043254 regulation of protein-containing complex assembly;GO:0051046 regulation of secretion;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P97411-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1Y8-1", "uniprot_id": "INP4B_MOUSE", "mass": 105160.0, "length": 927, "protein_name": "Type II inositol 3,4-bisphosphate 4-phosphatase", "gene_name": "Inpp4b", "organism": "Mouse", "refseq_name": "type II inositol 3,4-bisphosphate 4-phosphatase isoform 1", "refseq_ac": "NP_001284520", "gene_names_uniprotkb": "Inpp4b", "gene_names_refseq": "E130107I17Rik; Inpp4b", "protein_names_uniprotkb": "Type II inositol 3,4-bisphosphate 4-phosphatase; 3.1.3.66; Inositol polyphosphate 4-phosphatase type II", "protein_names_refseq": "D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphatidylinositol-3,4-bisphosphate 4-phosphatase; phosphoinositide 4-phosphatase; type II inositol 3,4-bisphosphate 4-phosphatase isoform 1; type II inositol 3,4-bisphosphate 4-phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:234515); (R-MMU-1660499); (R-MMU-1660516); (R-MMU-1855183)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "16247441;16631325;21750661;21982707;23078915;35760104;37389566", "class_list": "", "function": "Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (By similarity). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Hyperactivation of the PI3K/AKT pathway caused by the decrease in INPP4B in granulosa cells promotes an ovarian environment defective in folliculogenesis and conducive to teratoma formation., [RefSeq, PubMed]; In vivo mice deficient in Inpp4b displayed increased osteoclast differentiation rate and potential resulting in decreased bone mass and osteoporosis, [RefSeq, PubMed]; Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity., [RefSeq, PubMed]; Inpp4bbeta localized to the Golgi apparatus whereas Inpp4balpha was mainly cytosolic, suggesting a different cellular function for this isoform., [RefSeq, PubMed]; Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b., [RefSeq, PubMed]; This study provides first insight for a physiological role of PI-4-phosphatase II in the proerythroblast by controlling Epo responsiveness through a negative regulation of the PI3K/Akt pathway, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1A6U9;Q1A6V0;Q1A6V1", "ec_number_list": "3.1.3.66", "go_molecular_function": "GO:0034593 phosphatidylinositol bisphosphate phosphatase activity;GO:0017161 inositol-1,3,4-trisphosphate 4-phosphatase activity;GO:0052828 inositol-3,4-bisphosphate 4-phosphatase activity;GO:0008289 lipid binding;GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0046822 regulation of nucleocytoplasmic transport;GO:0006874 intracellular calcium ion homeostasis;GO:0045671 negative regulation of osteoclast differentiation;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6P1Y8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YE6-1", "uniprot_id": "IPO9_MOUSE", "mass": 116052.0, "length": 1041, "protein_name": "Importin-9", "gene_name": "Ipo9", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ipo9; Imp9; Ranbp9", "gene_names_refseq": "", "protein_names_uniprotkb": "Importin-9; Imp9a; Imp9b; Imp9; Importin-9a; Importin-9b; Ran-binding protein 9; RanBP9", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "11493596;11823430;21750661;22323606;25605945;28528544;31219806;33300544;34428180;39627609", "class_list": "", "function": "Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin (PubMed:11493596, PubMed:11823430, PubMed:22323606). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11493596, PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11493596, PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11493596, PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11493596, PubMed:11823430). Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex (By similarity). Mediates the nuclear import of histones H2A, H2B, H4 and H4 (PubMed:11493596, PubMed:11823430). In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions (By similarity). Mediates the nuclear import of actin (PubMed:22323606)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q924M3;Q924M4", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0042393 histone binding;GO:0061608 nuclear import signal receptor activity;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005634 nucleus", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0050821 protein stabilization;GO:0010498 proteasomal protein catabolic process;GO:0006606 protein import into nucleus;GO:0031144 proteasome localization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91YE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQR3-1", "uniprot_id": "KCNN1_MOUSE", "mass": 59330.0, "length": 537, "protein_name": "Small conductance calcium-activated potassium channel protein 1", "gene_name": "Kcnn1", "organism": "Mouse", "refseq_name": "small conductance calcium-activated potassium channel protein 1 isoform a", "refseq_ac": "NP_115773", "gene_names_uniprotkb": "Kcnn1; Sk1", "gene_names_refseq": "KCa2.1; Kcnn1; SK1; SKCa1", "protein_names_uniprotkb": "Small conductance calcium-activated potassium channel protein 1; KCa2.1; SK1; SKCa 1; SKCa1", "protein_names_refseq": "small conductance calcium-activated potassium channel protein 1 isoform a; small conductance calcium-activated potassium channel protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:84036); (R-MMU-1296052)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11267657;11557517;12882916;16055520;20689065;21750661;28274924;35820727;38912580", "class_list": "", "function": "Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 in kidney collecting duct cells., [RefSeq, PubMed]; ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain. Publication Status: Online-Only, [RefSeq, PubMed]; SK1, -2, -3, and IK1 (SK4) are expressed in islet cells and insulin-secreting cells and are able to influence glucose-induced calcium responses, thereby regulating insulin secretion., [RefSeq, PubMed]; Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:11267657, PubMed:11557517). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:11557517). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (By similarity). Activation is followed by membrane hyperpolarization (PubMed:11557517). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (Probable)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5CZY7;Q6JXY1;Q99JA9", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0044877 protein-containing complex binding;GO:0016286 small conductance calcium-activated potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection;GO:0030018 Z disc", "go_biological_process": "GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9EQR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41778-1", "uniprot_id": "PBX1_MOUSE", "mass": 46626.0, "length": 430, "protein_name": "Pre-B-cell leukemia transcription factor 1", "gene_name": "Pbx1", "organism": "Mouse", "refseq_name": "pre-B-cell leukemia transcription factor 1 isoform b", "refseq_ac": "NP_001278437", "gene_names_uniprotkb": "Pbx1; Pbx-1", "gene_names_refseq": "2310056B04Rik; D230003C07Rik; Pbx-1; Pbx1", "protein_names_uniprotkb": "Pre-B-cell leukemia transcription factor 1; Homeobox protein PBX1", "protein_names_refseq": "homeobox protein PBX1; pre-B-cell leukemia transcription factor 1 isoform b; pre-B-cell leukemia transcription factor 1", "tax_id": 10090, "disease": "congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay (Disease Ontology:DOID:0112359); glaucoma (Disease Ontology:DOID:1686); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:18514)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10082572;10523646;10933814;11279116;12409300;12529389;19799567;22180614;22560297;32190943;7791786;7913464;9315626;9525891;9710595", "class_list": "", "function": "(Microbial infection) In complex with PREP1, binds to the 5'-TGATTGAC-3' consensus sequence in the U5 region of Moloney murine leukemia virus and promotes viral transcription., [UniProtKB, PubMed]; As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element., [UniProtKB, PubMed]; Pbx1 is a novel lupus susceptibility gene that regulates T cell activation and tolerance., [RefSeq, PubMed]; This gene encodes a homeobox protein that belongs to the three-amino-acid loop extension/Pre-B cell leukemia transcription factor (TALE/PBX) family of proteins. The encoded protein is involved in several biological processes during embryogenesis including steroidogenesis, sexual development and the maintenance of hematopoietic stem cells. This protein functions in the development of several organ systems and plays a role in skeletal patterning and programming. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]., [RefSeq]; Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (By similarity). Binds the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (By similarity). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (By similarity). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (PubMed:19799567). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (PubMed:32190943). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (PubMed:7913464). Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4 (By similarity). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (PubMed:22560297). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0035162 embryonic hemopoiesis;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P41778-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18533-1", "uniprot_id": "HVM62_MOUSE", "mass": 13223.0, "length": 117, "protein_name": "Immunoglobulin heavy variable 3-5", "gene_name": "Ighv3-5", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ighv3-5", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 3-5; Ig heavy chain V region 733", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 2, "publication_id_list": "21750661;2499654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UY2-1", "uniprot_id": "KCMF1_MOUSE", "mass": 41791.0, "length": 381, "protein_name": "E3 ubiquitin-protein ligase KCMF1", "gene_name": "Kcmf1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase KCMF1 isoform 1", "refseq_ac": "NP_062689", "gene_names_uniprotkb": "Kcmf1; Debt91", "gene_names_refseq": "1700094M07Rik; Debt91; Kcmf1; Pmcf", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase KCMF1; 2.3.2.27; Debt-91; Differentially expressed in branching tubulogenesis 91", "protein_names_refseq": "E3 ubiquitin-protein ligase KCMF1 isoform 1; E3 ubiquitin-protein ligase KCMF1; RING-type E3 ubiquitin transferase KCMF1; clone DEBT-91; debt-91; differentially expressed in branching tubulogenesis 91; potassium channel modulatory factor DEBT-91", "tax_id": 10090, "disease": "", "pathway": " (mmu:74287); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12810064;20473331;21750661;22517741;28135057;31219806;32782141;33300544", "class_list": "", "function": "Data suggest that Debt91 is an immediate early gene up-regulated during growth factor-induced branching tubulogenesis., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (By similarity). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Does not ubiquitinate proteins that are acetylated at the N-terminus (By similarity). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (By similarity). Catalytic component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex that turns off the mitochondrial stress response after a specific stress event has been resolved (By similarity). The SIFI complex ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors such as ABHD10 (By similarity). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (By similarity)., [UniProtKB, UniProtKB]; KCMF1 mediates pro-oncogenic functions in vitro and in vivo and downregulation of KCMF1 results in the inhibition of pancreatic cancer formation in mice, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUM2", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;3.1.6.12;2.7.10.2;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0005764 lysosome", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006413 translational initiation;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q80UY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70380-1", "uniprot_id": "IL18_MOUSE", "mass": 22135.0, "length": 192, "protein_name": "Interleukin-18", "gene_name": "Il18", "organism": "Mouse", "refseq_name": "interleukin-18 isoform a", "refseq_ac": "NP_032386", "gene_names_uniprotkb": "Il18; Igif", "gene_names_refseq": "Igif; Il-18; Il18", "protein_names_uniprotkb": "Interleukin-18; IFN-gamma-inducing factor; IL-1 gamma; IL-18; Interferon gamma-inducing factor; Interleukin-1 gamma", "protein_names_refseq": "IFN-gamma-inducing factor; IL-1 gamma; interferon gamma-inducing factor; interleukin-1 gamma; interleukin-18 isoform a", "tax_id": 10090, "disease": "hemophagocytic lymphohistiocytosis (Disease Ontology:DOID:0050120); sleep apnea (Disease Ontology:DOID:0050847); stroke (Disease Ontology:DOID:0051061); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); cardiac arrest (Disease Ontology:DOID:0060319); intrahepatic cholestasis of pregnancy (Disease Ontology:DOID:0070227); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); COVID-19 (Disease Ontology:DOID:0080600); polymyositis (Disease Ontology:DOID:0080745); urinary tract infection (Disease Ontology:DOID:0080784); Graves ophthalmopathy (Disease Ontology:DOID:0081120); dermatomyositis (Disease Ontology:DOID:10223); respiratory failure (Disease Ontology:DOID:11162); sarcoidosis (Disease Ontology:DOID:11335); heart disease (Disease Ontology:DOID:114); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); paracoccidioidomycosis (Disease Ontology:DOID:12662); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); biliary atresia (Disease Ontology:DOID:13608); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); status epilepticus (Disease Ontology:DOID:1824); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); hepatitis B (Disease Ontology:DOID:2043); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); familial Mediterranean fever (Disease Ontology:DOID:2987); invasive ductal carcinoma (Disease Ontology:DOID:3008); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); ischemia (Disease Ontology:DOID:326); atopic dermatitis (Disease Ontology:DOID:3310); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); brain edema (Disease Ontology:DOID:4724); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); myositis (Disease Ontology:DOID:633); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); vasculitis (Disease Ontology:DOID:865); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); diabetic retinopathy (Disease Ontology:DOID:8947); steatotic liver disease (Disease Ontology:DOID:9452); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16173); (R-MMU-448706); (R-MMU-5620971); (R-MMU-9012546); (R-MMU-9960519); (R-MMU-9960525)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "21750661;26638072;26638073;30084848;30392956;34428180;37993712;37993714;7477296;9022080", "class_list": "", "function": "Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:26638072, PubMed:26638073). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (By similarity). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (By similarity). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:30392956)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 71, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045515 interleukin-18 receptor binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0045092 interleukin-18 receptor complex;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane;GO:0140368 decoy receptor complex", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0032736 positive regulation of interleukin-13 production;GO:0051142 positive regulation of NK T cell proliferation;GO:2000504 positive regulation of blood vessel remodeling;GO:0032740 positive regulation of interleukin-17 production", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70380-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18826-1", "uniprot_id": "KPB1_MOUSE", "mass": 138825.0, "length": 1241, "protein_name": "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform", "gene_name": "Phka1", "organism": "Mouse", "refseq_name": "phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform 1", "refseq_ac": "NP_032858", "gene_names_uniprotkb": "Phka1", "gene_names_refseq": "5330411D17; 9830108K24Rik; Phka1; Phka", "protein_names_uniprotkb": "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase kinase alpha M subunit", "protein_names_refseq": "phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform 1; phosphorylase kinase alpha M subunit", "tax_id": 10090, "disease": "glycogen storage disease IXd (Disease Ontology:DOID:0111040); hypothyroidism (Disease Ontology:DOID:1459); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (mmu:18679); (R-MMU-70221)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21183079;21750661;2602386;31599954;34428180;35820727;37507081;39927985;8298647", "class_list": "", "function": "Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AI90", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005964 phosphorylase kinase complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0046777 protein autophosphorylation;GO:0005980 glycogen catabolic process;GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P18826-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1G2-1", "uniprot_id": "KDM2B_MOUSE", "mass": 149733.0, "length": 1309, "protein_name": "Lysine-specific demethylase 2B", "gene_name": "Kdm2b", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 2B isoform 1", "refseq_ac": "NP_001003953", "gene_names_uniprotkb": "Kdm2b; Fbl10; Fbxl10; Jhdm1b; Kiaa3014", "gene_names_refseq": "Cxxc2; Fbl10; Fbxl10; Jhdm1b; Kdm2b; PCCX2", "protein_names_uniprotkb": "Lysine-specific demethylase 2B; 1.14.11.27; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; [Histone-H3]-lysine-36 demethylase 1B", "protein_names_refseq": "F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box protein containing leucine repeats 10; F-box/LRR-repeat protein 10; [Histone-H3]-lysine-36 demethylase 1B; jmjC domain-containing histone demethylation protein 1B; lysine-specific demethylase 2B isoform 1; lysine-specific demethylase 2B", "tax_id": 10090, "disease": "T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:30841); (R-MMU-3214842)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10531037;17296600;18836456;21220025;21750661;24856970;25428506;30779550", "class_list": "", "function": "Genetic ablation in embryonic stem cells reveal that deletion of PRC1 has genome-wide effects on PRC2 occupancy and H3K27me3; recognition of nonmethylated DNA by KDM2B, part of the PCGF1/PRC1 variant complex, is important for deposition of H2AK119ub1 and recruitment of PRC2 to a subset of CpG island targets and that this activity is essential for normal mouse development., [RefSeq, PubMed]; Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (By similarity). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicate that Jhdm1b is an H3K36 demethylase that regulates cell proliferation and senescence through p15(Ink4b)., [RefSeq, PubMed]; Results suggest that the Fbxl10 gene makes important contributions to embryonic neural development by regulating cell proliferation and cell death in mice., [RefSeq, PubMed]; Study using a high throughput proteomics approach identified interactors with Rnf2 including Fbxl10/Jhdm1B, casein kinase subunits, and the BcoR corepressor, [RefSeq, PubMed]; The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V396;Q6PFD0;Q6ZPE8;Q9CSF7;Q9QZN6", "ec_number_list": "1.14.11.27;1.14.11.69;1.14.11.66;1.14.11.79", "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0019843 rRNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0019005 SCF ubiquitin ligase complex;GO:0005694 chromosome", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0021555 midbrain-hindbrain boundary morphogenesis;GO:0021592 fourth ventricle development;GO:0021993 initiation of neural tube closure;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6P1G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JN2-1", "uniprot_id": "KLH22_MOUSE", "mass": 71687.0, "length": 634, "protein_name": "Kelch-like protein 22", "gene_name": "Klhl22", "organism": "Mouse", "refseq_name": "kelch-like protein 22 isoform 1", "refseq_ac": "NP_663454", "gene_names_uniprotkb": "Klhl22", "gene_names_refseq": "2610318I18Rik; Kelchl; Klhl22", "protein_names_uniprotkb": "Kelch-like protein 22", "protein_names_refseq": "kelch-like protein 22 isoform 1; kelch-like protein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:224023); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;29769719;31219806;34428180;36440598", "class_list": "", "function": "Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development., [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (By similarity). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy (PubMed:29769719)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3YW27;Q8BT13", "ec_number_list": "", "go_molecular_function": "GO:0071889 14-3-3 protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0030307 positive regulation of cell growth;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99JN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4H1-1", "uniprot_id": "KFA_MOUSE", "mass": 34229.0, "length": 305, "protein_name": "Kynurenine formamidase", "gene_name": "Afmid", "organism": "Mouse", "refseq_name": "kynurenine formamidase isoform 3", "refseq_ac": "NP_082103", "gene_names_uniprotkb": "Afmid", "gene_names_refseq": "9030621K19Rik; Afmid; Ammd; FKF; KFA; Kf; formylase", "protein_names_uniprotkb": "Kynurenine formamidase; 3.5.1.9; Arylformamidase; FKF; KFA; KFase; N-formylkynurenine formamidase", "protein_names_refseq": "KFase; N-formylkynurenine formamidase; formylkynureninase; kynurenine formamidase isoform 3; kynurenine formamidase; probable arylformamidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:71562)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12007602;12411446;15866519;15935693;21750661;31827172;34428180", "class_list": "", "function": "Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites., [UniProtKB, HAMAP, PubMed]; Monitoring type 2 diabetes from volatile faecal metabolome in Cushing's syndrome and single Afmid mouse models via a longitudinal study. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AQK9;Q80XP3;Q8R1K6", "ec_number_list": "3.5.1.9", "go_molecular_function": "GO:0004061 arylformamidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K4H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3R6-1", "uniprot_id": "KATL2_MOUSE", "mass": 61153.0, "length": 539, "protein_name": "Katanin p60 ATPase-containing subunit A-like 2", "gene_name": "Katnal2", "organism": "Mouse", "refseq_name": "katanin p60 ATPase-containing subunit A-like 2 isoform 4", "refseq_ac": "NP_081997", "gene_names_uniprotkb": "Katnal2; KATNAL2", "gene_names_refseq": "3110023G01Rik; 4933439B08Rik; Katnal2", "protein_names_uniprotkb": "Katanin p60 ATPase-containing subunit A-like 2; 5.6.1.1; Katanin p60 subunit A-like 2; p60 katanin-like 2", "protein_names_refseq": "katanin p60 ATPase-containing subunit A-like 2 isoform 4; katanin p60 ATPase-containing subunit A-like 2; p60 katanin-like 2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:71206)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26153462;29136647;34096614;38718086;38916997", "class_list": "", "function": "Authors present data suggesting that depending on context, KATNAL2 can partner with the regulatory protein KATNB1 or act autonomously. Data indicate KATNAL2 may regulate delta- and epsilon-tubulin rather than classical alpha-beta-tubulin microtubule polymers, suggesting the katanin family has a greater diversity of function than previously realised. Publication Status: Online-Only, [RefSeq, PubMed]; Biallelic mutations in KATNAL2 cause male infertility due to oligo-astheno-teratozoospermia., [RefSeq, PubMed]; KATNAL2 isoforms interact with themselves, with each other and with Nubp1 and Nubp2., [RefSeq, PubMed]; Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics., [RefSeq, PubMed]; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6NSQ2", "ec_number_list": "", "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0051013 microtubule severing;GO:0000212 meiotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D3R6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPW0-1", "uniprot_id": "INP4A_MOUSE", "mass": 105540.0, "length": 939, "protein_name": "Inositol polyphosphate-4-phosphatase type I A", "gene_name": "Inpp4a", "organism": "Mouse", "refseq_name": "inositol polyphosphate-4-phosphatase type I A isoform 3", "refseq_ac": "NP_001277726", "gene_names_uniprotkb": "Inpp4a", "gene_names_refseq": "107kDa; 9630012D15; D130048C09Rik; Inpp4a", "protein_names_uniprotkb": "Inositol polyphosphate-4-phosphatase type I A; 3.1.3.66; 4-Ptase-1; Inositol polyphosphate 4-phosphatase type I; Inositol polyphosphate 4-phosphatase-1; Type I inositol 3,4-bisphosphate 4-phosphatase", "protein_names_refseq": "4-Ptase-1; inositol polyphosphate 4-phosphatase-1; inositol polyphosphate-4-phosphatase type I A isoform 3; inositol polyphosphate-4-phosphatase type I A; type I inositol 3,4-bisphosphate 4-phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:269180); (R-MMU-1660499); (R-MMU-1660516); (R-MMU-1855183)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11087841;11485317;19325558;20463662;21183079;21750661;25428506;25869668;31219806;32631807;32848054;34203471;34428180;35822049;37415561;38363325;38720166;40021952", "class_list": "", "function": "Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity., [RefSeq, PubMed]; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:11087841, PubMed:19325558). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (PubMed:20463662)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate. Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps., [RefSeq, PubMed]; MicroRNA-223-3p regulates allergic in fl ammation by targeting INPP4A., [RefSeq, PubMed]; Plausible role of INPP4A dysregulation in idiopathic pulmonary fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CBJ8", "ec_number_list": "3.1.3.66", "go_molecular_function": "GO:0017161 inositol-1,3,4-trisphosphate 4-phosphatase activity;GO:0052828 inositol-3,4-bisphosphate 4-phosphatase activity;GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006798 polyphosphate catabolic process;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels;GO:0044281 small molecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9EPW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VBP7-1", "uniprot_id": "SHSL1_MOUSE", "mass": 22482.0, "length": 198, "protein_name": "Protein shisa-like-1", "gene_name": "Shisal1", "organism": "Mouse", "refseq_name": "protein shisa-like-1 isoform 1 precursor", "refseq_ac": "NP_001156617", "gene_names_uniprotkb": "Shisal1; 1810041L15Rik; Kiaa1644", "gene_names_refseq": "1810041L15Rik; Kiaa1644; Shisal1", "protein_names_uniprotkb": "Protein shisa-like-1", "protein_names_refseq": "protein shisa-like-1 isoform 1 precursor; protein shisa-like-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72301)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5D2;Q6ZPK6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VBP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80V72-1", "uniprot_id": "IP6K2_MOUSE", "mass": 51644.0, "length": 448, "protein_name": "Inositol hexakisphosphate kinase 2", "gene_name": "Ip6k2", "organism": "Mouse", "refseq_name": "inositol hexakisphosphate kinase 2 isoform 1", "refseq_ac": "NP_083910", "gene_names_uniprotkb": "Ip6k2; Ihpk2", "gene_names_refseq": "1500005N04Rik; Ihpk2; Ip6k2", "protein_names_uniprotkb": "Inositol hexakisphosphate kinase 2; 2.7.4.-; InsP6 kinase 2; P(i)-uptake stimulator; PiUS", "protein_names_refseq": "inositol hexakisphosphate kinase 2 isoform 1; inositol hexakisphosphate kinase 2; insP6 kinase 2; p(i)-uptake stimulator; piUS", "tax_id": 10090, "disease": "", "pathway": " (mmu:76500); (R-MMU-1855191)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10574768;19430495;21750661;25428506;30084848;30779550;33547244;35353626;38317282", "class_list": "", "function": "Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) (By similarity). May play a role in the regulation of Na(+)-dependent phosphate cotransport, possibly via its role in diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) biosynthesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma., [RefSeq, PubMed]; Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B., [RefSeq, PubMed]; Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling., [RefSeq, PubMed]; The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMT6", "ec_number_list": "2.7.4.21;2.7.-.-;2.7.4.-", "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0000832 inositol hexakisphosphate 5-kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0097243 flavonoid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030054 cell junction;GO:0001650 fibrillar center", "go_biological_process": "GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0043065 positive regulation of apoptotic process;GO:0050821 protein stabilization;GO:0030308 negative regulation of cell growth;GO:0071902 positive regulation of protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80V72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN12-1", "uniprot_id": "INAVA_MOUSE", "mass": 72693.0, "length": 663, "protein_name": "Innate immunity activator protein", "gene_name": "Inava", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Inava", "gene_names_refseq": "", "protein_names_uniprotkb": "Innate immunity activator protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "inflammatory bowel disease 29 (Disease Ontology:DOID:0112155)", "pathway": " (mmu:67313)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;29420262;30084848", "class_list": "", "function": "Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (By similarity). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN27;Q8BGK3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0002221 pattern recognition receptor signaling pathway;GO:1903409 reactive oxygen species biosynthetic process;GO:0043410 positive regulation of MAPK cascade;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TN12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZ49-1", "uniprot_id": "KLH35_MOUSE", "mass": 62372.0, "length": 574, "protein_name": "Kelch-like protein 35", "gene_name": "Klhl35", "organism": "Mouse", "refseq_name": "kelch-like protein 35", "refseq_ac": "NP_082421", "gene_names_uniprotkb": "Klhl35", "gene_names_refseq": "2810406K13Rik; Klhl35", "protein_names_uniprotkb": "Kelch-like protein 35", "protein_names_refseq": "kelch-like protein 35", "tax_id": 10090, "disease": "", "pathway": " (mmu:72184)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25605945;34418053", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QMG1", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CZ49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921I2-1", "uniprot_id": "KLDC4_MOUSE", "mass": 64860.0, "length": 584, "protein_name": "Kelch domain-containing protein 4", "gene_name": "Klhdc4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Klhdc4", "gene_names_refseq": "", "protein_names_uniprotkb": "Kelch domain-containing protein 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:234825)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;30084848;34428180;40997131", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIK0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q921I2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47809-1", "uniprot_id": "MP2K4_MOUSE", "mass": 44114.0, "length": 397, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 4", "gene_name": "Map2k4", "organism": "Mouse", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 4 isoform b", "refseq_ac": "NP_033183", "gene_names_uniprotkb": "Map2k4; Jnkk1; Mek4; Mkk4; Prkmk4; Sek1; Serk1; Skk1", "gene_names_refseq": "JNKK1; MAPKK 4; MEK4; MKK4; Map2k4; PRKMK4; Sek1; Serk1", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 4; 2.7.12.2; C-JUN N-terminal kinase kinase 1; JNK kinase 1; JNK-activating kinase 1; JNKK 1; MAP kinase kinase 4; MAPK/ERK kinase 4; MAPKK 4; MEK 4; SAPK/ERK kinase 1; SEK1", "protein_names_refseq": "C-JUN N-terminal kinase kinase 1; JNK kinase 1; JNK-activating kinase 1; MAP kinase kinase 4; MAPK/ERK kinase 4; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; dual specificity mitogen-activated protein kinase kinase 4 isoform b; dual specificity mitogen-activated protein kinase kinase 4", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); ovarian serous carcinoma (Disease Ontology:DOID:0050933); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); invasive ductal carcinoma (Disease Ontology:DOID:3008); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); prostate carcinoma in situ (Disease Ontology:DOID:8634); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:26398); (R-MMU-2559580); (R-MMU-2871796); (R-MMU-450321)", "pathway_count": 4, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;10095085;11390361;12391307;12401521;12624093;17496909;17875933;19265040;20801953;21183079;21333379;21750661;24129315;30779550;33175451;33300544;34502457;36210013;7997269;9620683;9891090", "class_list": "", "function": "Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The role of MKK4 in T-cell development and immunity to viral infections., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 15, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.10.1;2.7.12.1;2.7.11.22;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.3.2.23;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008545 JUN kinase kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030424 axon;GO:0043204 perikaryon;GO:0032839 dendrite cytoplasm", "go_biological_process": "GO:0038127 ERBB signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0007528 neuromuscular junction development;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P47809-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35738-1", "uniprot_id": "KLF12_MOUSE", "mass": 44105.0, "length": 402, "protein_name": "Krueppel-like factor 12", "gene_name": "Klf12", "organism": "Mouse", "refseq_name": "Krueppel-like factor 12", "refseq_ac": "NP_034766", "gene_names_uniprotkb": "Klf12; Ap2rep", "gene_names_refseq": "2700063E05Rik; AP-2rep; B130052C06Rik; D530033K05Rik; Klf12", "protein_names_uniprotkb": "Krueppel-like factor 12; Transcriptional repressor AP-2rep", "protein_names_refseq": "Krueppel-like factor 12; Kruppel-like factor 12; transcriptional repressor AP-2rep", "tax_id": 10090, "disease": "", "pathway": " (mmu:16597)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;29475398;31300511;34104947;37606530;40997131;9858544", "class_list": "", "function": "A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signaling pathway in micedagger., [RefSeq, PubMed]; Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter., [UniProtKB]; KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer., [RefSeq, PubMed]; Klf12 expression is down-regulated in kidney tissues of Pkd2f/f mice. miR-20b-5p and miR-106a-5p directly target Klf12 mRNA by binding to the 3'-UTR of Klf12., [RefSeq, PubMed]; We found that KLF12 regulates mouse NK cell proliferation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NWV9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35738-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VI75-1", "uniprot_id": "IPO4_MOUSE", "mass": 119275.0, "length": 1082, "protein_name": "Importin-4", "gene_name": "Ipo4", "organism": "Mouse", "refseq_name": "importin-4 isoform 1", "refseq_ac": "NP_077229", "gene_names_uniprotkb": "Ipo4; Imp4a; Ranbp4", "gene_names_refseq": "8430408O15Rik; Imp4a; Ipo4; RanBP4", "protein_names_uniprotkb": "Importin-4; Imp4a; Imp4; Importin-4a; Ran-binding protein 4; RanBP4", "protein_names_refseq": "imp4; importin 4a; importin-4 isoform 1; ran-binding protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:75751)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11823430;16166738;20173027;20805509;21750661;22872234;25428506;30084848;30779550;31599954;33300544;33649389;34428180;36210013;36852467;39627609", "class_list": "", "function": "Metallothionein deficient mice have a marked decrease in Importin 4 transcripts during acute lung injury, [RefSeq, PubMed]; Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B). Also mediates the nuclear import of monomeric histones H3.1 and H4. Mediates the ligand-independent nuclear import of vitamin D receptor (VDR)., [UniProtKB, UniProtKB]; Report a function of IPO4 and nuclear import in the Fanconi anemia pathway of DNA repair, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBW0;Q99J52", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport;GO:0006913 nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8VI75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BST6-1", "uniprot_id": "PELI2_MOUSE", "mass": 46272.0, "length": 419, "protein_name": "E3 ubiquitin-protein ligase pellino homolog 2", "gene_name": "Peli2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase pellino homolog 2 isoform 1", "refseq_ac": "NP_291080", "gene_names_uniprotkb": "Peli2", "gene_names_refseq": "Peli2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase pellino homolog 2; 2.3.2.27; Pellino-2; RING-type E3 ubiquitin transferase pellino homolog 2", "protein_names_refseq": "E3 ubiquitin-protein ligase pellino homolog 2 isoform 1; E3 ubiquitin-protein ligase pellino homolog 2; RING-type E3 ubiquitin transferase pellino homolog 2; protein pellino homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:93834); (R-MMU-9020702); (R-MMU-937039); (R-MMU-975144)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "11306823;12370331;15213237;21750661;22669975;29674674;32738922;34588221;35809381", "class_list": "", "function": "Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway., [RefSeq, PubMed]; Dibutyl phthalate promotes juvenile Sertoli cell proliferation by decreasing the levels of the E3 ubiquitin ligase Pellino 2. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Pellino 2 plays a critical role for TLR/IL-1R-mediated post-transcriptional control., [RefSeq, PubMed]; Pellino-2 is a tissue-restricted component of a signaling pathway that couples the mouse pelle-like kinase/IL-1 receptor-associated kinase protein to IL-1- or lipopolysaccharide-dependent signaling., [RefSeq, PubMed]; Pellino2 accelerate inflammation and pyroptosis via the ubiquitination and activation of NLRP3 inflammation in model of pediatric pneumonia., [RefSeq, PubMed]; The functions of Pellino2 in the NLRP3 pathway are dependent on Pellino2 FHA and RING-like domains, with Pellino2 promoting the ubiquitination of NLRP3 during the priming phase of activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4F2;Q8CC65;Q8R2X4;Q9ERJ7", "ec_number_list": "2.3.2.23;2.7.11.1;2.3.2.27", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0043410 positive regulation of MAPK cascade;GO:0000209 protein polyubiquitination;GO:0008592 regulation of Toll signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BST6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08672-1", "uniprot_id": "KIFC2_MOUSE", "mass": 85686.0, "length": 792, "protein_name": "Kinesin-like protein KIFC2", "gene_name": "Kifc2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Kifc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinesin-like protein KIFC2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:16581); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11259594;21750661;9115736;9115737", "class_list": "", "function": "May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08613", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0032839 dendrite cytoplasm", "go_biological_process": "GO:0007411 axon guidance;GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex;GO:0048489 synaptic vesicle transport;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08672-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70315-1", "uniprot_id": "WASP_MOUSE", "mass": 54192.0, "length": 520, "protein_name": "Actin nucleation-promoting factor WAS", "gene_name": "Was", "organism": "Mouse", "refseq_name": "actin nucleation-promoting factor WAS", "refseq_ac": "NP_033541", "gene_names_uniprotkb": "Was; Wasp", "gene_names_refseq": "Wasp; Was", "protein_names_uniprotkb": "Actin nucleation-promoting factor WAS; WASp; Wiskott-Aldrich syndrome protein homolog", "protein_names_refseq": "Wiskott-Aldrich syndrome homolog; actin nucleation-promoting factor WAS; wiskott-Aldrich syndrome protein homolog", "tax_id": 10090, "disease": "X-linked severe congenital neutropenia (Disease Ontology:DOID:0112128); thrombocytopenia (Disease Ontology:DOID:1588); IgA glomerulonephritis (Disease Ontology:DOID:2986); Wiskott-Aldrich syndrome (Disease Ontology:DOID:9169)", "pathway": " (mmu:22376)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17947660;19144319;21183079;23437151;26740625;31219806;34428180;8666397;8910519;9488710", "class_list": "", "function": "Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0008064 regulation of actin polymerization or depolymerization;GO:0006955 immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042110 T cell activation;GO:0008154 actin polymerization or depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70315-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFA1-1", "uniprot_id": "IRAK2_MOUSE", "mass": 69047.0, "length": 622, "protein_name": "Interleukin-1 receptor-associated kinase-like 2", "gene_name": "Irak2", "organism": "Mouse", "refseq_name": "interleukin-1 receptor-associated kinase-like 2 isoform b", "refseq_ac": "NP_001107025", "gene_names_uniprotkb": "Irak2", "gene_names_refseq": "6330415L08Rik; IRAK-2; Irak2", "protein_names_uniprotkb": "Interleukin-1 receptor-associated kinase-like 2; IRAK-2; mu-IRAK-2", "protein_names_refseq": "interleukin-1 receptor-associated kinase 2c; interleukin-1 receptor-associated kinase-like 2 isoform b; interleukin-1 receptor-associated kinase-like 2; mu-IRAK-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:108960); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-9020702); (R-MMU-937042); (R-MMU-937072); (R-MMU-975163)", "pathway_count": 8, "publication_count": 14, "publication_id_list": "12220507;15082713;19224205;20173027;21750661;25605945;28990926;30084848;30779550;31219806;34428180;36210013;36768848;38072993", "class_list": "", "function": "Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid beta-oxidation to alleviate diabetic cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Alternative splicing of the Irak2 gene in mice will generate agonistic or antagonistic Irak2 isoforms, which is likely to have consequences for the regulation of Toll-like receptors signaling., [RefSeq, PubMed]; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization., [UniProtKB]; IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3K2;Q3U7F5;Q3UFX2;Q5U404;Q6YBR8;Q6YBR9;Q6YBS0;Q6YBS1;Q8C5M0;Q8CC82;Q8CEA0", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0070555 response to interleukin-1", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CFA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UV74-1", "uniprot_id": "ITB2L_MOUSE", "mass": 81547.0, "length": 738, "protein_name": "Integrin beta-2-like protein", "gene_name": "Itgb2l", "organism": "Mouse", "refseq_name": "integrin beta-2-like protein precursor", "refseq_ac": "NP_032431", "gene_names_uniprotkb": "Itgb2l", "gene_names_refseq": "5033406G21Rik; Itgb2l; pactolus", "protein_names_uniprotkb": "Integrin beta-2-like protein; Protein pactolus", "protein_names_refseq": "integrin beta-2-like protein precursor; integrin beta-2-like protein; protein pactolus", "tax_id": 10090, "disease": "leukocyte adhesion deficiency 1 (Disease Ontology:DOID:0110910); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); cancer (Disease Ontology:DOID:162); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); coronary restenosis (Disease Ontology:DOID:4247); leukocyte adhesion deficiency (Disease Ontology:DOID:6612); myocarditis (Disease Ontology:DOID:820)", "pathway": " (mmu:16415)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10556426;11461913;14662885;16735694;16836649;17523188;21750661;25428506;31219806;34428180;39627609;9535848", "class_list": "", "function": "During inflammatory stimulation, plays a role in retaining Cxcl13-expressing cells at the site of the inflammatory response., [UniProtKB, PubMed]; Pactolus does not function as a neutrophil phagocytic or adhesion receptor, but may instead serve as a sugar-bearing ligand for lectin recognition by other cells., [RefSeq, PubMed]; These data implicate Smuc as blocking Pactolus transcription in cells expressing PU.1 (and CD18) but not Pactolus., [RefSeq, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "O88424;Q2KHL5", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0001540 amyloid-beta binding;GO:0031072 heat shock protein binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0030141 secretory granule;GO:0044853 plasma membrane raft", "go_biological_process": "GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0032930 positive regulation of superoxide anion generation;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3UV74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ06-1", "uniprot_id": "TOLIP_MOUSE", "mass": 30345.0, "length": 274, "protein_name": "Toll-interacting protein", "gene_name": "Tollip", "organism": "Mouse", "refseq_name": "toll-interacting protein isoform 1", "refseq_ac": "NP_076253", "gene_names_uniprotkb": "Tollip", "gene_names_refseq": "4930403G24Rik; 4931428G15Rik; Tollip", "protein_names_uniprotkb": "Toll-interacting protein", "protein_names_refseq": "toll-interacting protein isoform 1", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:54473); (R-MMU-6798695); (R-MMU-9020702)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10854325;14563850;21750661;26495903;26740625;28011936;35803695;35820727;37828378;38078859;38528148", "class_list": "", "function": "A Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin, [RefSeq, PubMed]; BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation., [RefSeq, PubMed]; Component of the signaling pathway of IL-1 and Toll-like receptors (By similarity). Inhibits cell activation by microbial products (By similarity). Recruits IRAK1 to the IL-1 receptor complex (By similarity). Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (By similarity). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity)., [UniProtKB, UniProtKB]; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P)., [UniProtKB, UniProtKB, UniProtKB]; TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis., [RefSeq, PubMed]; TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543N1;Q9D5P5", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005150 interleukin-1, type I receptor binding;GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0030855 epithelial cell differentiation;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QZ06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61153-1", "uniprot_id": "IOD1_MOUSE", "mass": 29568.0, "length": 257, "protein_name": "Type I iodothyronine deiodinase", "gene_name": "Dio1", "organism": "Mouse", "refseq_name": "type I iodothyronine deiodinase", "refseq_ac": "NP_031886", "gene_names_uniprotkb": "Dio1; Itdi1; Txdi1", "gene_names_refseq": "5DI; D1; Dio1; ITDI1; TXDI1", "protein_names_uniprotkb": "Type I iodothyronine deiodinase; 1.21.99.3; 1.21.99.4; 5DI; DIOI; Type 1 DI; Type-I 5'-deiodinase", "protein_names_refseq": "DIOI; type 1 DI; type I iodothyronine deiodinase; type-I 5'-deiodinase", "tax_id": 10090, "disease": "thyroid gland disease (Disease Ontology:DOID:50)", "pathway": " (mmu:13370); (R-MMU-350864)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18339710;18821722;21750661;32718224;37298533;7476994", "class_list": "", "function": "Chronic Exposure to Chlorpyrifos Damages Thyroid Activity and Imbalances Hepatic Thyroid Hormones Signaling and Glucose Metabolism: Dependency of T3-FOXO1 Axis by Hyperglycemia. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:18821722, PubMed:32718224). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) via outer-ring deiodination (ORD) (PubMed:32718224, PubMed:18339710). Catalyzes the deiodination of T4 to rT3, 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), T3 to 3,3'-T2 and 3,3'-T2 to 3-T1 via inner-ring deiodination (IRD) (PubMed:18821722, PubMed:32718224). Catalyzes the deiodiantion of 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via ORD (By similarity). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine, 3',5'-diiodothyronamine and 3,3'-diiodothyronamine as well as tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine (PubMed:18339710). Catalyzes the deiodination of L-thyroxine sulfate and 3,3',5-triiodo-L-thyronine sulfate via IRD and of 3,3',5'-triiodo-L-thyronine sulfate via ORD (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Apr 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05CY5;Q5FW63", "ec_number_list": "1.21.99.3;1.21.99.4", "go_molecular_function": "GO:0033798 thyroxine 5-deiodinase activity;GO:0004800 thyroxine 5'-deiodinase activity;GO:0008430 selenium binding", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042404 thyroid hormone catabolic process;GO:0042446 hormone biosynthetic process;GO:0006520 amino acid metabolic process;GO:0042403 thyroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61153-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1X4-1", "uniprot_id": "ILF3_MOUSE", "mass": 96021.0, "length": 898, "protein_name": "Interleukin enhancer-binding factor 3", "gene_name": "Ilf3", "organism": "Mouse", "refseq_name": "interleukin enhancer-binding factor 3 isoform 2", "refseq_ac": "NP_001036172", "gene_names_uniprotkb": "Ilf3", "gene_names_refseq": "Ilf3; MBII-26; MPHOSPH4; NF90; NFAR", "protein_names_uniprotkb": "Interleukin enhancer-binding factor 3", "protein_names_refseq": "M phase phosphoprotein 4; interleukin enhancer-binding factor 3 isoform 2; nuclear factor 90; nuclear factor associated with dsRNA", "tax_id": 10090, "disease": "", "pathway": " (mmu:16201); (R-MMU-9762293); (R-MMU-9833482)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10337617;11438536;15364895;21123651;21183079;21750661;25428506;26495903;28528544;31219806;37453647;38395749;38583797;38862515;39627609;7519613", "class_list": "", "function": "Characterization of NFAR-1 and NFAR-2 splice forms in human sample, [RefSeq, PubMed]; Cloning of human NF90, [RefSeq, PubMed]; Deficiency of smooth muscle cell ILF3 alleviates intimal hyperplasia via HMGB1 mRNA degradation-mediated regulation of the STAT3/DUSP16 axis., [RefSeq, PubMed]; RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs., [UniProtKB, UniProtKB, PubMed]; Role of ATF3 triggering M2 macrophage polarization to protect against the inflammatory injury of sepsis through ILF3/NEAT1 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene contains two double-stranded RNA binding domains and functions in the post-transcriptional regulation of gene expression. It is a component of an RNA-protein complex that may be involved in mediating the export of messenger RNAs. Alternative splicing results in multiple transcript variants encoding distinct isoforms. These isoforms are grouped into two categories, NFAR-1 or NFAR-2, based on variation at the C-terminus. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VD5;Q812A1;Q8BP80;Q8C2H8;Q8K588", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0001618 virus receptor activity;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9Z1X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35594-1", "uniprot_id": "IFT81_MOUSE", "mass": 79285.0, "length": 676, "protein_name": "Intraflagellar transport protein 81 homolog", "gene_name": "Ift81", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 81 homolog isoform a", "refseq_ac": "NP_034009", "gene_names_uniprotkb": "Ift81; Cdv-1; Cdv1", "gene_names_refseq": "Cdv-1r; Cdv-1; Cdv1; Ift81", "protein_names_uniprotkb": "Intraflagellar transport protein 81 homolog; CDV-1; Carnitine deficiency-associated protein expressed in ventricle 1", "protein_names_refseq": "carnitine deficiency-associated gene expressed in ventricle 1; carnitine deficiency-associated protein expressed in ventricle 1; intraflagellar transport 81 homolog; intraflagellar transport protein 81 homolog isoform a; intraflagellar transport protein 81 homolog", "tax_id": 10090, "disease": "short-rib thoracic dysplasia 19 with or without polydactyly (Disease Ontology:DOID:0080295)", "pathway": " (mmu:12589); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10210276;11130971;12549821;19253336;21750661;23055941;23810713;25428506;32233951;34428180;41182177;9187371", "class_list": "", "function": "Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling (By similarity). Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella (PubMed:32233951)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; IFT81 plays an essential role during spermatogenesis by modulating the assembly and elongation of the sperm flagella., [RefSeq, PubMed]; Inconsistent expression levels of human CDV-1 and mouse Cdv-1 in heart implied that cardiac hypertrophy in human SCD might not be associated with the abnormal expression of CDV-1., [RefSeq, PubMed]; May be involved in cardiac hypertrophy caused by carnitine deficiency., [UniProtKB, PubMed]; May play a role in development of the testis and spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8R4W2;Q9CSA1;Q9EQM1", "ec_number_list": "", "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0060271 cilium assembly;GO:0008589 regulation of smoothened signaling pathway;GO:0035735 intraciliary transport involved in cilium assembly;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O35594-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WI7-1", "uniprot_id": "ITFG2_MOUSE", "mass": 48971.0, "length": 443, "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "Itfg2", "organism": "Mouse", "refseq_name": "KICSTOR complex protein ITFG2", "refseq_ac": "NP_598688", "gene_names_uniprotkb": "Itfg2", "gene_names_refseq": "2700050P07Rik; Itfg2", "protein_names_uniprotkb": "KICSTOR complex protein ITFG2; Integrin-alpha FG-GAP repeat-containing protein 2", "protein_names_refseq": "KICSTOR complex protein ITFG2; integrin-alpha FG-GAP repeat-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:101142); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;23997217", "class_list": "", "function": "As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose., [UniProtKB, UniProtKB]; These results identify Itfg2 as a novel contributor to B cell differentiation and a negative regulator of the autoimmune response during lupus., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYJ5;Q8R148", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0140007 KICSTOR complex;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0002314 germinal center B cell differentiation;GO:0042149 cellular response to glucose starvation;GO:0032006 regulation of TOR signaling;GO:0034198 cellular response to amino acid starvation;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91WI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TG1-1", "uniprot_id": "KANL1_MOUSE", "mass": 113179.0, "length": 1036, "protein_name": "KAT8 regulatory NSL complex subunit 1", "gene_name": "Kansl1", "organism": "Mouse", "refseq_name": "KAT8 regulatory NSL complex subunit 1 isoform 1", "refseq_ac": "NP_001074514", "gene_names_uniprotkb": "Kansl1; 1700081L11Rik; Kiaa1267; Nsl1", "gene_names_refseq": "1700081L11Rik; 9430041J06Rik; Kansl1; mKIAA1267", "protein_names_uniprotkb": "KAT8 regulatory NSL complex subunit 1; NSL complex protein NSL1; Non-specific lethal 1 homolog", "protein_names_refseq": "KAT8 regulatory NSL complex subunit 1 isoform 1; NSL complex protein NSL1; non-specific lethal 1 homolog", "tax_id": 10090, "disease": "Koolen de Vries syndrome (Disease Ontology:DOID:0050880); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:76719); (R-MMU-3214847); (R-MMU-9772755)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "21183079;21750661;24842875;25428506;28704368;30084848;34428180;35177641;36852467;37813994;40997131", "class_list": "", "function": "Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice. Erratum:[Nat Commun. 2022 Mar 17;13(1):1575. doi: 10.1038/s41467-022-29129-3. PMID: 35301327] Publication Status: Online-Only, [RefSeq, PubMed]; Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (By similarity). The NSL complex also acts as a regulator of gene expression in mitochondria (By similarity). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (By similarity). Associates with microtubule ends and contributes to microtubule stability (By similarity)., [UniProtKB, UniProtKB]; Our results demonstrate the implication of KANSL1 in the manifestation of Koolen-de Vries syndrome phenotypes and extend substantially our knowledge about biological processes affected by these mutations. Clear differences in social behavior and gene expression profiles between Del/+ and Kansl1+/- mice suggested potential roles of other genes affected by the 17q21.31 deletion. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2A5Y5;Q3TT88;Q3U5D8;Q3V3N3;Q7TMU3;Q80XP7;Q8R3L6;Q9D9G0", "ec_number_list": "", "go_molecular_function": "GO:0035035 histone acetyltransferase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:1903108 regulation of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80TG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PD10-1", "uniprot_id": "IP6K1_MOUSE", "mass": 49307.0, "length": 433, "protein_name": "Inositol hexakisphosphate kinase 1", "gene_name": "Ip6k1", "organism": "Mouse", "refseq_name": "inositol hexakisphosphate kinase 1", "refseq_ac": "NP_038813", "gene_names_uniprotkb": "Ip6k1; Ihpk1", "gene_names_refseq": "1200016D08Rik; Ihpk1; InsP6k1; InsP6; Ip6k1; Itpk6", "protein_names_uniprotkb": "Inositol hexakisphosphate kinase 1; 2.7.4.21; Inositol hexaphosphate kinase 1; InsP6 kinase 1", "protein_names_refseq": "inositol hexakisphosphate kinase 1; inositol hexakisphosphate kinase 6; insP6 kinase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27399); (R-MMU-1855167); (R-MMU-1855191)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10574768;18268345;21750661;25428506;31219806;36210013;37742721;38317282", "class_list": "", "function": "Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4., [UniProtKB, PubMed]; Defects in the mutants indicate important roles for IP6K1 and inositol pyrophosphates in several physiological functions, [RefSeq, PubMed]; Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium., [RefSeq, PubMed]; The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXV6", "ec_number_list": "2.7.4.21;2.7.-.-;2.7.4.-", "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0000832 inositol hexakisphosphate 5-kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0120163 negative regulation of cold-induced thermogenesis;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6PD10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U8K7-1", "uniprot_id": "KMT5B_MOUSE", "mass": 98580.0, "length": 883, "protein_name": "Histone-lysine N-methyltransferase KMT5B", "gene_name": "Kmt5b", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase KMT5B isoform d", "refseq_ac": "NP_001161356", "gene_names_uniprotkb": "Kmt5b; Suv420h1", "gene_names_refseq": "C630029K18Rik; Kmt5b; Suv4-20h1; Suv420h1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase KMT5B; 2.1.1.361; 2.1.1.362; Lysine-specific methyltransferase 5B; Su(var)4-20 homolog 1; Suppressor of variegation 4-20 homolog 1; Suv4-20h1; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B", "protein_names_refseq": "[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase KMT5B isoform d; histone-lysine N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H1; lysine-specific methyltransferase 5B; su(var)4-20 homolog 1; suppressor of variegation 4-20 homolog 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 51 (Disease Ontology:DOID:0080232)", "pathway": " (mmu:225888); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15145825;15750587;16612004;17846168;21750661;23720823;24049080;28114273;36897941;37116939", "class_list": "", "function": "Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:15145825, PubMed:24049080, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (PubMed:15145825). Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions (PubMed:15145825). KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (PubMed:15750587, PubMed:16612004). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice., [RefSeq, PubMed]; The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus. Publication Status: Online-Only, [RefSeq, PubMed]; There is a novel role for histone lysine methylation in controlling telomere recombination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTP6;Q6DI74;Q6Q784;Q8BU67;Q8BUN0;Q8BUT7;Q8BW73;Q8BZ24;Q91X81", "ec_number_list": "2.1.1.-;2.1.1.364;2.1.1.361;2.1.1.362;2.1.1.359;2.1.1.355;2.1.1.354", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0042054 histone methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:0042799 histone H4K20 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005886 plasma membrane", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0007517 muscle organ development;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3U8K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEM9-1", "uniprot_id": "KLDC3_MOUSE", "mass": 43082.0, "length": 382, "protein_name": "Kelch domain-containing protein 3", "gene_name": "Klhdc3", "organism": "Mouse", "refseq_name": "kelch domain-containing protein 3", "refseq_ac": "NP_001157201", "gene_names_uniprotkb": "Klhdc3; Peas", "gene_names_refseq": "1300011D16Rik; Klhdc3; Peas", "protein_names_uniprotkb": "Kelch domain-containing protein 3; Testis intracellular mediator protein", "protein_names_refseq": "kelch domain-containing protein 3; protein Peas; testis intracellular mediator protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71765)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12444059;12606021;21750661;31219806;34743205", "class_list": "", "function": "CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation., [RefSeq, PubMed]; Cloned human and mouse Peas cDNAs (hPEAS/mPeas) and analyzed their tissue and stage-specific expressions; may be involved in meiotic recombination process, [RefSeq, PubMed]; Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons. The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine (By similarity). May be involved in meiotic recombination process (PubMed:12606021)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCN9;Q3UR95;Q91XU6;Q99JH9;Q9DBG8", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0051321 meiotic cell cycle;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VEM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMY7-1", "uniprot_id": "ISK2_MOUSE", "mass": 9722.0, "length": 86, "protein_name": "Serine protease inhibitor Kazal-type 2", "gene_name": "Spink2", "organism": "Mouse", "refseq_name": "serine protease inhibitor Kazal-type 2 isoform 4 precursor", "refseq_ac": "NP_001276697", "gene_names_uniprotkb": "Spink2", "gene_names_refseq": "1700007F22Rik; HUSI-II; Spink2", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 2", "protein_names_refseq": "acrosin-trypsin inhibitor; serine protease inhibitor Kazal-type 2 isoform 4 precursor; serine protease inhibitor Kazal-type 2", "tax_id": 10090, "disease": "spermatogenic failure 29 (Disease Ontology:DOID:0111930)", "pathway": " (mmu:69982)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21705336;21750661;24699552;28554943", "class_list": "", "function": "As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:21705336, PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (PubMed:21705336). It also inhibits trypsin (PubMed:21705336)., [UniProtKB, PubMed, PubMed]; Overexpression of different variants of Spink2 in D407 tissue culture cells increases their susceptibility to the apoptosis-inducing agent staurosporine in a manner consistent with the differential susceptibility between the DBA/2J and BALB/cByJ strains Publication Status: Online-Only, [RefSeq, PubMed]; SPINK2 is required for maintaining normal spermatogenesis and potentially regulates serine protease-mediated apoptosis in male germ cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z3X9;Q5M8S4", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle;GO:0043005 neuron projection", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BMY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01869-1", "uniprot_id": "IGH1M_MOUSE", "mass": 43387.0, "length": 393, "protein_name": "Ig gamma-1 chain C region, membrane-bound form", "gene_name": "Ighg1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ighg1; Igh-4", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig gamma-1 chain C region, membrane-bound form", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-977606)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;113776;115593;2108149;21750661;33725478;34428180;34887587;35984892;36288343;36583994;37453647;37507081;5073237;6283537;6769752;6799207;6804950;98524", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 6, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0034988 Fc-gamma receptor I complex binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009897 external side of plasma membrane;GO:0042571 immunoglobulin complex, circulating", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0019731 antibacterial humoral response;GO:0002455 humoral immune response mediated by circulating immunoglobulin;GO:0050766 positive regulation of phagocytosis;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P01869-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TY65-1", "uniprot_id": "ICA1L_MOUSE", "mass": 48160.0, "length": 431, "protein_name": "Islet cell autoantigen 1-like protein", "gene_name": "Ica1l", "organism": "Mouse", "refseq_name": "islet cell autoantigen 1-like protein isoform a", "refseq_ac": "NP_001303623", "gene_names_uniprotkb": "Ica1l; Als2cr15", "gene_names_refseq": "1700030B17Rik; Als2cr15; Ica1l; b2b3465Clo", "protein_names_uniprotkb": "Islet cell autoantigen 1-like protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog; Ica69-related protein", "protein_names_refseq": "Ica69-related protein; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 15; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog; islet cell autoantigen 1-like protein isoform a; islet cell autoantigen 1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:70375)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;26306493", "class_list": "", "function": "ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXB8;Q6PD23;Q8C0R6;Q9D9S5", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0140090 membrane curvature sensor activity", "go_cellular_component": "GO:0030667 secretory granule membrane;GO:0001669 acrosomal vesicle;GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0097753 membrane bending;GO:0007286 spermatid development;GO:0051046 regulation of secretion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TY65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZQA6-1", "uniprot_id": "IGSF3_MOUSE", "mass": 134710.0, "length": 1194, "protein_name": "Immunoglobulin superfamily member 3", "gene_name": "Igsf3", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily member 3 isoform 1 precursor", "refseq_ac": "NP_997088", "gene_names_uniprotkb": "Igsf3; Kiaa0466", "gene_names_refseq": "1700016K10Rik; 2810035F16Rik; 4833439O17Rik; Igsf3; mKIAA0466", "protein_names_uniprotkb": "Immunoglobulin superfamily member 3; IgSF3", "protein_names_refseq": "immunoglobulin superfamily member 3 isoform 1 precursor", "tax_id": 10090, "disease": "lacrimal duct obstruction (Disease Ontology:DOID:13929)", "pathway": " (mmu:78908)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19349973;21750661;24372406;26495903;27328461;30084848;30899004;37821496", "class_list": "", "function": "IGSF3 is a novel regulator of neuronal morphogenesis that might function through interactions with multiple partners., [RefSeq, PubMed]; Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X9;Q7TPV3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0032808 lacrimal gland development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q6ZQA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63248-1", "uniprot_id": "IPKA_MOUSE", "mass": 7960.0, "length": 76, "protein_name": "cAMP-dependent protein kinase inhibitor alpha", "gene_name": "Pkia", "organism": "Mouse", "refseq_name": "cAMP-dependent protein kinase inhibitor alpha", "refseq_ac": "NP_032888", "gene_names_uniprotkb": "Pkia", "gene_names_refseq": "PKIalpha; Pkia", "protein_names_uniprotkb": "cAMP-dependent protein kinase inhibitor alpha; PKI-alpha; cAMP-dependent protein kinase inhibitor, muscle/brain isoform", "protein_names_refseq": "PKI-alpha; cAMP-dependent protein kinase inhibitor alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:18767)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1710219;21750661;30016717;32830375;32848054;8443157", "class_list": "", "function": "Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains., [UniProtKB, UniProtKB, UniProtKB]; Protein kinase A inhibitor proteins (PKIs) divert GPCR-Galphas-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P27776;Q3UTL0", "ec_number_list": "", "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000480 negative regulation of cAMP-dependent protein kinase activity;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006469 negative regulation of protein kinase activity;GO:0010389 regulation of G2/M transition of mitotic cell cycle;GO:0043086 negative regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P63248-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAI2-1", "uniprot_id": "IFT22_MOUSE", "mass": 20833.0, "length": 185, "protein_name": "Intraflagellar transport protein 22 homolog", "gene_name": "Ift22", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 22 homolog", "refseq_ac": "NP_080349", "gene_names_uniprotkb": "Ift22; Rabl5", "gene_names_refseq": "3110017O03Rik; Ift22; Rabl5", "protein_names_uniprotkb": "Intraflagellar transport protein 22 homolog; Rab-like protein 5", "protein_names_refseq": "RAB, member of RAS oncogene family-like 5; intraflagellar transport protein 22 homolog; rab-like protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:67286); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19253336;21750661", "class_list": "", "function": "Small GTPase-like component of the intraflagellar transport (IFT) complex B., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0012505 endomembrane system;GO:0030991 intraciliary transport particle A;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0060271 cilium assembly;GO:0042073 intraciliary transport;GO:0035720 intraciliary anterograde transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DAI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4C5-1", "uniprot_id": "IL17C_MOUSE", "mass": 21592.0, "length": 194, "protein_name": "Interleukin-17C", "gene_name": "Il17c", "organism": "Mouse", "refseq_name": "interleukin-17C", "refseq_ac": "NP_665833", "gene_names_uniprotkb": "Il17c", "gene_names_refseq": "IL-17C; Il17c", "protein_names_uniprotkb": "Interleukin-17C; Cytokine CX2; Il-17c", "protein_names_refseq": "cytokine CX2; interleukin-17C", "tax_id": 10090, "disease": "", "pathway": " (mmu:234836)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12077275;17982105;21750661;21982598;21993848;21993849;32174926;32331702;33411748;37263138", "class_list": "", "function": "Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NFKB and MAPK pathways. Acts synergically with IL22, TNF and IL1B in inducing antibacterial peptides. May have protective function by maintaining epithelial homeostasis after an inflammatory challenge, such as that caused in the intestine by dextran sulfate sodium in a colitis model. May also promote an inflammatory phenotype, such as skin in a psoriasis model. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases, such as autoimmune encephalitis., [UniProtKB, PubMed, PubMed, PubMed]; IL-17B and IL-17C play an important role in the pathogenesis of inflammatory arthritis., [RefSeq, PubMed]; IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations. Publication Status: Online-Only, [RefSeq, PubMed]; IL-17C has a pathogenic role in kidney ischemia/reperfusion injury., [RefSeq, PubMed]; IL-17C neutralization protects the kidney against acute injury and chronic injury., [RefSeq, PubMed]; IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Intranasal administration of adenovirus expressing IL-17 results in bronchoalveolar lavage neutrophilia and Th1-type inflammatory gene expression in the lung., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6F0", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0006954 inflammatory response;GO:1900017 positive regulation of cytokine production involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K4C5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3A0-1", "uniprot_id": "HSC20_MOUSE", "mass": 26645.0, "length": 234, "protein_name": "Iron-sulfur cluster co-chaperone protein HscB", "gene_name": "Hscb", "organism": "Mouse", "refseq_name": "iron-sulfur cluster co-chaperone protein HscB isoform 1", "refseq_ac": "NP_705799", "gene_names_uniprotkb": "Hscb; Hsc20", "gene_names_refseq": "Hsc20; Hscb", "protein_names_uniprotkb": "Iron-sulfur cluster co-chaperone protein HscB", "protein_names_refseq": "HscB iron-sulfur cluster co-chaperone homolog; J-type co-chaperone HSC20; iron-sulfur cluster co-chaperone protein HscB isoform 1; iron-sulfur cluster co-chaperone protein HscB, mitochondrial", "tax_id": 10090, "disease": "sideroblastic anemia 5 (Disease Ontology:DOID:0061007); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (mmu:100900); (R-MMU-1268020); (R-MMU-1362409); (R-MMU-6799198); (R-MMU-9865881)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;32634119", "class_list": "", "function": "Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (By similarity). Plays an essential role in hematopoiesis (PubMed:32634119)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V294", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0060319 primitive erythrocyte differentiation;GO:0051259 protein complex oligomerization;GO:0030218 erythrocyte differentiation;GO:0060215 primitive hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K3A0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSN7-1", "uniprot_id": "IGSF5_MOUSE", "mass": 40292.0, "length": 370, "protein_name": "Immunoglobulin superfamily member 5", "gene_name": "Igsf5", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily member 5 isoform 3 precursor", "refseq_ac": "NP_082354", "gene_names_uniprotkb": "Igsf5; Jam4", "gene_names_refseq": "2010003D20Rik; Igsf5; JCAM; Jam4", "protein_names_uniprotkb": "Immunoglobulin superfamily member 5; IgSF5; JAM-4; Junctional adhesion molecule 4", "protein_names_refseq": "JAM-4; cell adhesion molecule JCAM; immunoglobulin superfamily member 5 isoform 3 precursor; junction adhesion molecule 4; junctional adhesion molecule 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:72058)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12773569;16832352;16982697;21750661", "class_list": "", "function": "JAM4 together with MAGI-1 provides an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells, [RefSeq, PubMed]; LNX1 provides an endocytic scaffold for JAM4 that is implicated in the reorganization of cell junctions., [RefSeq, PubMed]; Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; These results suggest that JAM4 is expressed in stem cells and progenitor cells but that other cell adhesion molecules may substitute for JAM4 function in JAM4-deficient mice both in male germ cell and hematopoietic lineages., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8G2", "ec_number_list": "", "go_molecular_function": "GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TSN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06798-1", "uniprot_id": "HXA4_MOUSE", "mass": 30468.0, "length": 285, "protein_name": "Homeobox protein Hox-A4", "gene_name": "Hoxa4", "organism": "Mouse", "refseq_name": "homeobox protein Hox-A4", "refseq_ac": "NP_032291", "gene_names_uniprotkb": "Hoxa4; Hox-1.4; Hoxa-4", "gene_names_refseq": "Hox-1.4; Hoxa4", "protein_names_uniprotkb": "Homeobox protein Hox-A4; Homeobox protein Hox-1.4; Homeobox protein MH-3", "protein_names_refseq": "homeo box A4; homeobox protein Hox-1.4; homeobox protein Hox-A4; homeobox protein MH-3", "tax_id": 10090, "disease": "leukemia (Disease Ontology:DOID:1240)", "pathway": " (mmu:15401)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1686835;21750661;2426103;2563568;2576648;2895600;3726554;7901228;7909702", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61684;Q64388;Q8BPE6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0048704 embryonic skeletal system morphogenesis;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P06798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35345-1", "uniprot_id": "IMA7_MOUSE", "mass": 59964.0, "length": 536, "protein_name": "Importin subunit alpha-7", "gene_name": "Kpna6", "organism": "Mouse", "refseq_name": "importin subunit alpha-7", "refseq_ac": "NP_032494", "gene_names_uniprotkb": "Kpna6; Kpna5", "gene_names_refseq": "IPOA7; Kpna5; Kpna6; NPI-2", "protein_names_uniprotkb": "Importin subunit alpha-7; Importin alpha-S2; Karyopherin subunit alpha-6", "protein_names_refseq": "importin alpha 7; importin alpha-S2; importin subunit alpha-7; karyopherin (importin) alpha 5; karyopherin (importin) alpha 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:16650); (R-MMU-68616)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;18716025;21750661;25605945;31219806;33300544;34428180;34473250;9369227", "class_list": "", "function": "Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus., [UniProtKB]; Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U388;Q9CVP9", "ec_number_list": "", "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043657 host cell;GO:0042564 NLS-dependent protein nuclear import complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060135 maternal process involved in female pregnancy;GO:0019079 viral genome replication;GO:1903902 positive regulation of viral life cycle;GO:0006607 NLS-bearing protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35345-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUG6-1", "uniprot_id": "INSL5_MOUSE", "mass": 15524.0, "length": 135, "protein_name": "Insulin-like peptide INSL5", "gene_name": "Insl5", "organism": "Mouse", "refseq_name": "insulin-like peptide INSL5 isoform 1 precursor", "refseq_ac": "NP_001277577", "gene_names_uniprotkb": "Insl5; Rif2; Rif; Zins3", "gene_names_refseq": "Insl5; RIF2", "protein_names_uniprotkb": "Insulin-like peptide INSL5; Insulin-like peptide 5; Relaxin/insulin-like factor 2; Relaxin/insulin-like protein", "protein_names_refseq": "insulin-like peptide INSL5 isoform 1 precursor; insulin-like peptide INSL5; relaxin/insulin-like factor 2; relaxin/insulin-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:23919); (R-MMU-418594); (R-MMU-444821)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10458910;10598589;16601133;21750661;25028498;28857318;33519716", "class_list": "", "function": "Immune System Effects of Insulin-Like Peptide 5 in a Mouse Model. Publication Status: Online-Only, [RefSeq, PubMed]; Insl5 is an orexigenic hormone released from colonic L-cells, which promotes appetite during conditions of energy deprivation., [RefSeq, PubMed]; Insulin-like peptide 5 is expressed in mouse brain and has a role in mobilization of calcium, [RefSeq, PubMed]; Mass spectral analysis of purified enteroendocrine cells and tissue homogenates identified the exact sequence of A and B chains of INSL5 endogenously expressed in L-cells., [RefSeq, PubMed]; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:2000253 positive regulation of feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WUG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23813-1", "uniprot_id": "HXD11_MOUSE", "mass": 33546.0, "length": 323, "protein_name": "Homeobox protein Hox-D11", "gene_name": "Hoxd11", "organism": "Mouse", "refseq_name": "homeobox protein Hox-D11", "refseq_ac": "NP_032299", "gene_names_uniprotkb": "Hoxd11; Hox-4.6; Hoxd-11", "gene_names_refseq": "E230017H14Rik; Hox-4.6; Hox-5.4; Hox-5.5; Hoxd11", "protein_names_uniprotkb": "Homeobox protein Hox-D11; Homeobox protein Hox-4.6; Homeobox protein Hox-5.5", "protein_names_refseq": "homeo box D11; homeobox protein Hox-4.6; homeobox protein Hox-5.5; homeobox protein Hox-D11", "tax_id": 10090, "disease": "", "pathway": " (mmu:15431)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1676674;21750661;7902810", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001759 organ induction;GO:0010720 positive regulation of cell development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P23813-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34902-1", "uniprot_id": "IL2RG_MOUSE", "mass": 42241.0, "length": 369, "protein_name": "Cytokine receptor common subunit gamma", "gene_name": "Il2rg", "organism": "Mouse", "refseq_name": "cytokine receptor common subunit gamma isoform a precursor", "refseq_ac": "NP_038591", "gene_names_uniprotkb": "Il2rg", "gene_names_refseq": "CD132; Il2rg; [g]c; gamma(c); gc; p64", "protein_names_uniprotkb": "Cytokine receptor common subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; Interleukin-2 receptor subunit gamma; gammaC; p64", "protein_names_refseq": "IL-2 receptor subunit gamma; IL-2R subunit gamma; common gamma chain; cytokine receptor common subunit gamma isoform a precursor; cytokine receptor common subunit gamma; gamma C receptor; interleukin-2 receptor subunit gamma", "tax_id": 10090, "disease": "X-linked severe combined immunodeficiency (Disease Ontology:DOID:0060013); COVID-19 (Disease Ontology:DOID:0080600); severe combined immunodeficiency (Disease Ontology:DOID:627); combined T cell and B cell immunodeficiency (Disease Ontology:DOID:628)", "pathway": " (mmu:16186); (R-MMU-1266695); (R-MMU-5673001); (R-MMU-6785807); (R-MMU-8983432); (R-MMU-8985947); (R-MMU-9020558); (R-MMU-9020958); (R-MMU-912526)", "pathway_count": 9, "publication_count": 10, "publication_id_list": "16075062;21750661;26495903;28315936;7718508;7805729;8359699;8378320;8503926;8750189", "class_list": "", "function": "Common subunit for the receptors for a variety of interleukins (PubMed:7718508). Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity;GO:0019976 interleukin-2 binding;GO:0042010 interleukin-15 receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0035771 interleukin-4-mediated signaling pathway;GO:0038110 interleukin-2-mediated signaling pathway;GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0010628 positive regulation of gene expression;GO:0019725 cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P34902-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01573-1", "uniprot_id": "IFNA2_MOUSE", "mass": 21922.0, "length": 190, "protein_name": "Interferon alpha-2", "gene_name": "Ifna2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ifna2", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon alpha-2; IFN-alpha-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); common cold (Disease Ontology:DOID:10459); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); Crimean-Congo hemorrhagic fever (Disease Ontology:DOID:12287); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:15965); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;2987810;6188104;6689487", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61717", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01573-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70139-1", "uniprot_id": "IPKG_MOUSE", "mass": 7943.0, "length": 76, "protein_name": "cAMP-dependent protein kinase inhibitor gamma", "gene_name": "Pkig", "organism": "Mouse", "refseq_name": "cAMP-dependent protein kinase inhibitor gamma isoform 1", "refseq_ac": "NP_001034479", "gene_names_uniprotkb": "Pkig", "gene_names_refseq": "PKIgamma; Pkig", "protein_names_uniprotkb": "cAMP-dependent protein kinase inhibitor gamma; PKI-gamma", "protein_names_refseq": "cAMP-dependent protein kinase inhibitor gamma isoform 1; cAMP-dependent protein kinase inhibitor gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:18769)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15345747;15557275;16870489;21750661;9218452", "class_list": "", "function": "Endogenous levels of PKI regulate PKA signaling, [RefSeq, PubMed]; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results indicate that the downregulation of PKIgamma may be prerequisite for the PKA activation during the osteoblastic differentiation of precursor cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004862 cAMP-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006469 negative regulation of protein kinase activity;GO:0042308 negative regulation of protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O70139-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02831-1", "uniprot_id": "HXA3_MOUSE", "mass": 46430.0, "length": 443, "protein_name": "Homeobox protein Hox-A3", "gene_name": "Hoxa3", "organism": "Mouse", "refseq_name": "homeobox protein Hox-A3", "refseq_ac": "NP_034582", "gene_names_uniprotkb": "Hoxa3; Hox-1.5; Hoxa-3", "gene_names_refseq": "Hox-1.5; Hoxa3; Mo-10", "protein_names_uniprotkb": "Homeobox protein Hox-A3; Homeobox protein Hox-1.5; Homeobox protein MO-10", "protein_names_refseq": "homeo box A3; homeobox protein Hox-1.5; homeobox protein Hox-A3; homeobox protein MO-10", "tax_id": 10090, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198)", "pathway": " (mmu:15400)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;2444477;2879282;6091896;8710855", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds 5' to its own homeobox., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9Z8;Q61197", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0030878 thyroid gland development;GO:0060017 parathyroid gland development;GO:0021615 glossopharyngeal nerve morphogenesis;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P02831-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55023-1", "uniprot_id": "IMPA1_MOUSE", "mass": 30436.0, "length": 277, "protein_name": "Inositol monophosphatase 1", "gene_name": "Impa1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Impa1", "gene_names_refseq": "", "protein_names_uniprotkb": "Inositol monophosphatase 1; 3.1.3.25; 3.1.3.94; D-galactose 1-phosphate phosphatase; IMP 1; IMPase 1; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 59 (Disease Ontology:DOID:0081221); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:55980); (R-MMU-1855183)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12877981;17068342;21540332;21750661;22645316;23027737;28528544;37828378;39927985", "class_list": "", "function": "Phosphatase involved in the dephosphorylation of myo-inositol monophosphate to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium Li(+) action in brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.-;2.1.1.-;3.1.3.94;3.1.3.25;3.1.3.9", "go_molecular_function": "GO:0031403 lithium ion binding;GO:0052834 inositol monophosphate phosphatase activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0007165 signal transduction;GO:0006796 phosphate-containing compound metabolic process;GO:0006661 phosphatidylinositol biosynthetic process;GO:0006021 inositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O55023-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHZ7-1", "uniprot_id": "IMP4_MOUSE", "mass": 33656.0, "length": 291, "protein_name": "U3 small nucleolar ribonucleoprotein protein IMP4", "gene_name": "Imp4", "organism": "Mouse", "refseq_name": "U3 small nucleolar ribonucleoprotein IMP4 isoform 1", "refseq_ac": "NP_848716", "gene_names_uniprotkb": "Imp4; D1Wsu40e", "gene_names_refseq": "D1Wsu40e; Imp4", "protein_names_uniprotkb": "U3 small nucleolar ribonucleoprotein protein IMP4; U3 snoRNP protein IMP4", "protein_names_refseq": "IMP4, U3 small nucleolar ribonucleoprotein, homolog; U3 small nucleolar ribonucleoprotein IMP4 isoform 1; U3 small nucleolar ribonucleoprotein IMP4; U3 small nucleolar ribonucleoprotein protein IMP4; U3 snoRNP protein 4 homolog; U3 snoRNP protein IMP4", "tax_id": 10090, "disease": "", "pathway": " (mmu:27993); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12655004;21750661;31219806;34428180", "class_list": "", "function": "Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8H6;Q8CI42;Q9CWN6;Q9CYT5", "ec_number_list": "", "go_molecular_function": "GO:0030515 snoRNA binding;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0030684 preribosome;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0034457 Mpp10 complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VHZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESM3-1", "uniprot_id": "HPLN2_MOUSE", "mass": 37925.0, "length": 341, "protein_name": "Hyaluronan and proteoglycan link protein 2", "gene_name": "Hapln2", "organism": "Mouse", "refseq_name": "hyaluronan and proteoglycan link protein 2 precursor", "refseq_ac": "NP_071314", "gene_names_uniprotkb": "Hapln2; Bral1", "gene_names_refseq": "4930401E20Rik; Bral1; Hapln2", "protein_names_uniprotkb": "Hyaluronan and proteoglycan link protein 2; Brain link protein 1", "protein_names_refseq": "brain link protein 1; hyaluronan and proteoglycan link protein 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:73940)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11027579;11817897;20181608;21750661;30125937", "class_list": "glycogene", "function": "Colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems., [RefSeq, PubMed]; Hapln4/Bral2 is a perineuronal nets component that selectively contributes to formation and transmission of Purkinje cells-deep cerebellar nuclei synapses in the cerebellum, [RefSeq, PubMed]; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid., [UniProtKB, PubMed]; These findings provide an understanding of the mechanisms underlying the accumulation of cations due to diffusion barriers around the nodes during saltatory conduction, emphasizing the importance of the Bral1-based extramilieu for neuronal conductivity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0045202 synapse;GO:0033268 node of Ranvier;GO:0072534 perineuronal net", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0008065 establishment of blood-nerve barrier", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ESM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0T8-1", "uniprot_id": "IKKE_MOUSE", "mass": 80953.0, "length": 717, "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit epsilon", "gene_name": "Ikbke", "organism": "Mouse", "refseq_name": "inhibitor of nuclear factor kappa-B kinase subunit epsilon", "refseq_ac": "NP_062751", "gene_names_uniprotkb": "Ikbke; Ikke; Ikki", "gene_names_refseq": "IKK-E; IKK-i; IKKepsilon; Ikbke; Ikki", "protein_names_uniprotkb": "Inhibitor of nuclear factor kappa-B kinase subunit epsilon; 2.7.11.10; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IKK-i; IkBKE; Inducible I kappa-B kinase", "protein_names_refseq": "I-kappa-B kinase epsilon; IKK-epsilon; inducible I kappa-B kinase; inducible IKappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon", "tax_id": 10090, "disease": "", "pathway": " (mmu:56489); (R-MMU-4755510); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-936440); (R-MMU-936964); (R-MMU-9824878); (R-MMU-9860927)", "pathway_count": 8, "publication_count": 17, "publication_id_list": "10421793;12736252;15210742;15879144;17332413;17568778;19737522;21750661;22065572;22171011;23396211;31219806;34428180;38167258;38324694;39261656;39409049", "class_list": "", "function": "Atypical inflammatory kinase IKBKE phosphorylates and inactivates FoxA1 to promote liver tumorigenesis., [RefSeq, PubMed]; IKKepsilon and TBK1 prevent RIPK1 dependent and independent inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; IKKepsilon-deficient macrophages impede cardiac repair after myocardial infarction by enhancing the macrophage-myofibroblast transition., [RefSeq, PubMed]; IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli., [RefSeq, PubMed]; In stimulated murine fibroblast-like synoviocyte cultures, induction of matrix metalloproteinases MMP3 and MMP13 is significantly greater in the IKK epsilon-positive cells compared with IKK epsilon-deficient cultures., [RefSeq, PubMed]; Knock-Out of IKKepsilon Ameliorates Atherosclerosis and Fatty Liver Disease by Alterations of Lipid Metabolism in the PCSK9 Model in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2I3", "ec_number_list": "2.3.2.27;2.7.11.10;2.7.11.1;3.1.3.48;2.3.2.-;3.4.19.12;2.3.2.31", "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0008384 IkappaB kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031966 mitochondrial membrane;GO:0016605 PML body", "go_biological_process": "GO:0006955 immune response;GO:0048255 mRNA stabilization;GO:0010884 positive regulation of lipid storage;GO:0060337 type I interferon-mediated signaling pathway;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9R0T8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49442-1", "uniprot_id": "INPP_MOUSE", "mass": 43346.0, "length": 396, "protein_name": "Inositol polyphosphate 1-phosphatase", "gene_name": "Inpp1", "organism": "Mouse", "refseq_name": "inositol polyphosphate 1-phosphatase", "refseq_ac": "NP_032410", "gene_names_uniprotkb": "Inpp1", "gene_names_refseq": "2300002C06Rik; Inpp1", "protein_names_uniprotkb": "Inositol polyphosphate 1-phosphatase; 3.1.3.57; IPPase; IPP", "protein_names_refseq": "IPPase; IPP; inositol polyphosphate 1-phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:16329); (R-MMU-1855183)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "18299400;20484733;21750661;21952136;22645316;25428506;30084848;31599954;32782141;32848054;33300544;33649389;34428180;35820727;35822049;37507081;40021952;40885482;8586440", "class_list": "", "function": "Mg(2+)-dependent phosphatase that catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate and participates in inositol phosphate metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3L1", "ec_number_list": "3.1.3.57;3.1.3.7", "go_molecular_function": "GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity;GO:0052829 inositol-1,3,4-trisphosphate 1-phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P49442-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WG1-1", "uniprot_id": "INSI2_MOUSE", "mass": 24915.0, "length": 225, "protein_name": "Insulin-induced gene 2 protein", "gene_name": "Insig2", "organism": "Mouse", "refseq_name": "insulin-induced gene 2 protein isoform 1", "refseq_ac": "NP_001258460", "gene_names_uniprotkb": "Insig2", "gene_names_refseq": "2900053I11Rik; C730043J18Rik; Insig-2; Insig2", "protein_names_uniprotkb": "Insulin-induced gene 2 protein; INSIG-2", "protein_names_refseq": "INSIG-2 membrane protein; insulin-induced gene 2 protein isoform 1; insulin-induced gene 2 protein", "tax_id": 10090, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:72999)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12242332;12624180;12869692;15528275;16100574;16955138;21750661;28849786;31953408;34428180;34974159;37858181", "class_list": "", "function": "A vitamin D response element in the murine Insig-2 promoter may have a role in the differentiation of 3T3-L1 preadipocytes, [RefSeq, PubMed]; CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing., [RefSeq, PubMed]; Insig-2 is an ER membrane protein negatively controlling lipid biosynthesis. The stabilized Insig-2 downregulates lipogenesis through inhibiting the SREBP pathway, helping to channel the carbon flux to ATP generation and protecting myotubes from lipid over-accumulation. Publication Status: Online-Only, [RefSeq, PubMed]; Insulin-induced gene 2 protects against hepatic ischemia-reperfusion injury via metabolic remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis., [RefSeq, PubMed]; Mediates feedback control of cholesterol synthesis., [UniProtKB, UniProtKB, UniProtKB]; Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:12624180, PubMed:16100574). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:16100574). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (By similarity). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (By similarity). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Results define Insig proteins 1 and 2 as essential elements of the feedback inhibition system of cholesterol synthesis in mouse liver., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMY2;Q8BWP1", "ec_number_list": "", "go_molecular_function": "GO:0008142 oxysterol binding;GO:0140311 protein sequestering activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032937 SREBP-SCAP-Insig complex", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process;GO:0032869 cellular response to insulin stimulus;GO:0042472 inner ear morphogenesis;GO:0045717 negative regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91WG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCU9-1", "uniprot_id": "HOGA1_MOUSE", "mass": 34644.0, "length": 321, "protein_name": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial", "gene_name": "Hoga1", "organism": "Mouse", "refseq_name": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor", "refseq_ac": "NP_080428", "gene_names_uniprotkb": "Hoga1; Dhdpsl", "gene_names_refseq": "0610010D20Rik; Dhdpsl; Hoga1; Npl2", "protein_names_uniprotkb": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial; 4.1.3.16; DHDPS-like protein; Dihydrodipicolinate synthase-like; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase", "protein_names_refseq": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; DHDPS-like protein; N-acetylneuraminate pyruvate lyase 2 (putative); dihydrodipicolinate synthase-like, mitochondrial; probable 2-keto-4-hydroxyglutarate aldolase; probable KHG-aldolase", "tax_id": 10090, "disease": "primary hyperoxaluria type 3 (Disease Ontology:DOID:0111672); primary hyperoxaluria (Disease Ontology:DOID:2977)", "pathway": " (mmu:67432); (R-MMU-389661)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;22872234;34428180;37453647", "class_list": "", "function": "Catalyzes the final step in the metabolic pathway of hydroxyproline., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91W74;Q9CY60", "ec_number_list": "4.1.3.16", "go_molecular_function": "GO:0008700 (R,S)-4-hydroxy-2-oxoglutarate aldolase activity;GO:0042803 protein homodimerization activity;GO:0106009 (4S)-4-hydroxy-2-oxoglutarate aldolase activity;GO:0016833 oxo-acid-lyase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0033609 oxalate metabolic process;GO:0042866 pyruvate biosynthetic process;GO:0019470 trans-4-hydroxy-L-proline catabolic process;GO:0046487 glyoxylate metabolic process;GO:0009436 glyoxylate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DCU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19182-1", "uniprot_id": "IFRD1_MOUSE", "mass": 49935.0, "length": 449, "protein_name": "Interferon-related developmental regulator 1", "gene_name": "Ifrd1", "organism": "Mouse", "refseq_name": "interferon-related developmental regulator 1", "refseq_ac": "NP_038590", "gene_names_uniprotkb": "Ifrd1; Tis7", "gene_names_refseq": "Ifnl; Ifrd1; PC4; Tis7", "protein_names_uniprotkb": "Interferon-related developmental regulator 1; Nerve growth factor-inducible protein PC4; TIS7 protein; TPA-induced sequence 7", "protein_names_refseq": "TPA-induced sequence 7; interferon-related developmental regulator 1; nerve growth factor-inducible protein PC4", "tax_id": 10090, "disease": "", "pathway": " (mmu:15982)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;2797820;28528544;32992150;37603466;6179042;7756174", "class_list": "", "function": "Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal., [UniProtKB]; IFRD1 regulates the asthmatic responses of airway via NF-kappaB pathway., [RefSeq, PubMed]; The gene IFRD1/PC4 is required for muscle differentiation. Inhibition of PC4 expression in myoblasts prevents morphological differentiation, impairing myogenin and myosin gene expression. This finding has been confirmed by gene knockout in mice., [RefSeq, PubMed]; The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15). Publication Status: Online-Only, [RefSeq, PubMed]; This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in mouse as TPA-inducible immediate early gene (named Tis7)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P21835;P70228;Q80XM4", "ec_number_list": "", "go_molecular_function": "GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0014706 striated muscle tissue development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P19182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09632-1", "uniprot_id": "HXB8_MOUSE", "mass": 27618.0, "length": 243, "protein_name": "Homeobox protein Hox-B8", "gene_name": "Hoxb8", "organism": "Mouse", "refseq_name": "homeobox protein Hox-B8", "refseq_ac": "NP_034591", "gene_names_uniprotkb": "Hoxb8; Hox-2.4; Hoxb-8", "gene_names_refseq": "Hox-2.4; Hoxb8", "protein_names_uniprotkb": "Homeobox protein Hox-B8; Homeobox protein Hox-2.4", "protein_names_refseq": "homeo box B8; homeobox protein Hox-2.4; homeobox protein Hox-B8", "tax_id": 10090, "disease": "trichotillomania (Disease Ontology:DOID:0050587)", "pathway": " (mmu:15416)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1673811;20173027;21750661;2564662;2891608;2907477;7791786", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008344 adult locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P09632-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23463-1", "uniprot_id": "HXD8_MOUSE", "mass": 31363.0, "length": 289, "protein_name": "Homeobox protein Hox-D8", "gene_name": "Hoxd8", "organism": "Mouse", "refseq_name": "homeobox protein Hox-D8 isoform a", "refseq_ac": "NP_032302", "gene_names_uniprotkb": "Hoxd8; Hox-4.3; Hoxd-8", "gene_names_refseq": "4921540P06Rik; Hox-4.3; Hox-5.4; Hoxd8", "protein_names_uniprotkb": "Homeobox protein Hox-D8; Homeobox protein Hox-4.3; Homeobox protein Hox-5.4", "protein_names_refseq": "homeo box D8; homeobox protein Hox-4.3; homeobox protein Hox-5.4; homeobox protein Hox-D8 isoform a; homeobox protein Hox-D8", "tax_id": 10090, "disease": "", "pathway": " (mmu:15437)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1348361;1675873;1683707;1982431;21750661;37752684", "class_list": "", "function": "HOXD8 suppresses renal cell carcinoma growth by upregulating SHMT1 expression., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ASN2", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P23463-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAM3-1", "uniprot_id": "HSPB9_MOUSE", "mass": 18493.0, "length": 168, "protein_name": "Heat shock protein beta-9", "gene_name": "Hspb9", "organism": "Mouse", "refseq_name": "heat shock protein beta-9", "refseq_ac": "NP_083583", "gene_names_uniprotkb": "Hspb9", "gene_names_refseq": "1700007H20Rik; Hspb9", "protein_names_uniprotkb": "Heat shock protein beta-9; HspB9", "protein_names_refseq": "heat shock protein beta-9; heat shock protein, alpha-crystallin-related, B9", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:75482)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11470154;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5F2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DAM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48997-1", "uniprot_id": "INVO_MOUSE", "mass": 54919.0, "length": 467, "protein_name": "Involucrin", "gene_name": "Ivl", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ivl", "gene_names_refseq": "", "protein_names_uniprotkb": "Involucrin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:16447)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15147942;21750661;8277848", "class_list": "", "function": "Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking;GO:0010224 response to UV-B;GO:0002786 regulation of antibacterial peptide production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P48997-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CX62-1", "uniprot_id": "INKA1_MOUSE", "mass": 31804.0, "length": 282, "protein_name": "PAK4-inhibitor INKA1", "gene_name": "Inka1", "organism": "Mouse", "refseq_name": "PAK4-inhibitor INKA1", "refseq_ac": "NP_080873", "gene_names_uniprotkb": "Inka1; 6230427J02Rik; Fam212a", "gene_names_refseq": "6230427J02Rik; Fam212a; Inka1", "protein_names_uniprotkb": "PAK4-inhibitor INKA1; Inca; Induced in neural crest by AP2-alpha protein homolog; Inka-box actin regulator 1", "protein_names_refseq": "MInca; PAK4-inhibitor INKA1; family with sequence similarity 212, member A; inca; induced in neural crest by AP2-alpha protein homolog; protein FAM212A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68176)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17314132;20175189;21750661", "class_list": "", "function": "Consistent with expression of Inka1 in tissues of the developing head during neurulation, a low percentage of Inka1(-/-) mice show exencephaly while the remainder are viable and fertile., [RefSeq, PubMed]; Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08EG3;Q80WB2;Q8BPE9", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CX62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35228-1", "uniprot_id": "IL27B_MOUSE", "mass": 25353.0, "length": 228, "protein_name": "Interleukin-27 subunit beta", "gene_name": "Ebi3", "organism": "Mouse", "refseq_name": "interleukin-27 subunit beta precursor", "refseq_ac": "NP_056581", "gene_names_uniprotkb": "Ebi3; Il27b", "gene_names_refseq": "EBI-3; Ebi3; IL-27", "protein_names_uniprotkb": "Interleukin-27 subunit beta; Epstein-Barr virus-induced gene 3 protein homolog; IL-27 subunit beta; IL-27B", "protein_names_refseq": "IL-27 subunit beta; IL-27B; epstein-Barr virus-induced gene 3 protein homolog; interleukin-27 subunit beta precursor; interleukin-27 subunit beta", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591)", "pathway": " (mmu:50498); (R-MMU-8984722); (R-MMU-9020956)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12482940;17294231;31219806;37534736", "class_list": "", "function": "Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines., [UniProtKB]; EBI3 plays a critical regulatory role in the induction of Th2-type immune responses and the development of Th2-mediated tissue inflammation in vivo., [RefSeq, PubMed]; Ebi3 knockout aggravates experimental periodontitis via Th17 polarization., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045523 interleukin-27 receptor binding;GO:0005125 cytokine activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0043235 receptor complex;GO:0070745 interleukin-35 complex", "go_biological_process": "GO:0042098 T cell proliferation;GO:0042129 regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35228-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35344-1", "uniprot_id": "IMA4_MOUSE", "mass": 57773.0, "length": 521, "protein_name": "Importin subunit alpha-4", "gene_name": "Kpna3", "organism": "Mouse", "refseq_name": "importin subunit alpha-4", "refseq_ac": "NP_032492", "gene_names_uniprotkb": "Kpna3; Qip2", "gene_names_refseq": "IPOA4; Kpna3", "protein_names_uniprotkb": "Importin subunit alpha-4; Importin alpha Q2; Karyopherin subunit alpha-3; Qip2", "protein_names_refseq": "importin alpha 4; importin alpha Q2; importin subunit alpha-3; importin subunit alpha-4; karyopherin (importin) alpha 3; qip2", "tax_id": 10090, "disease": "hereditary spastic paraplegia 88 (Disease Ontology:DOID:0070457)", "pathway": " (mmu:16648)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21183079;23386199;30084848;34428180;9369227", "class_list": "", "function": "Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0042564 NLS-dependent protein nuclear import complex", "go_biological_process": "GO:0006607 NLS-bearing protein import into nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35344-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54910-1", "uniprot_id": "IKBE_MOUSE", "mass": 39200.0, "length": 364, "protein_name": "NF-kappa-B inhibitor epsilon", "gene_name": "Nfkbie", "organism": "Mouse", "refseq_name": "NF-kappa-B inhibitor epsilon isoform 2", "refseq_ac": "NP_001291885", "gene_names_uniprotkb": "Nfkbie; Ikbe", "gene_names_refseq": "I-kappa-B-epsilon; IKBE; IkB-E; NF-kappa-BIE; Nfkbie; ikB-epsilon", "protein_names_uniprotkb": "NF-kappa-B inhibitor epsilon; I-kappa-B-epsilon; IkB-E; IkB-epsilon; IkappaBepsilon; NF-kappa-BIE", "protein_names_refseq": "NF-kappa-B inhibitor epsilon isoform 2; NF-kappa-B inhibitor epsilon; ikappaBepsilon", "tax_id": 10090, "disease": "collagen disease (Disease Ontology:DOID:854)", "pathway": " (mmu:18037); (R-MMU-1169091)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12424381;21750661;28135057;32170099;38486128;9405619", "class_list": "", "function": "NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia., [RefSeq, PubMed]; Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:32170099). Sequestered complexes include NFKB1/p50-RELA/p65 and NFKB1/p50-REL/c-Rel complexes (By similarity). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (PubMed:32170099)., [UniProtKB, UniProtKB, PubMed]; Temporal control of NF-kappaB activation by the coordinated degradation and synthesis of IkappaB proteins, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U686;Q9CZZ9;Q9D7U3", "ec_number_list": "", "go_molecular_function": "GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0042942 D-serine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54910-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01575-1", "uniprot_id": "IFNB_MOUSE", "mass": 22127.0, "length": 182, "protein_name": "Interferon beta", "gene_name": "Ifnb1", "organism": "Mouse", "refseq_name": "interferon beta precursor", "refseq_ac": "NP_034640", "gene_names_uniprotkb": "Ifnb1; Ifb; Ifnb", "gene_names_refseq": "IFN-beta; IFNB; If1da1; Ifb; Ifnb1", "protein_names_uniprotkb": "Interferon beta; IFN-beta", "protein_names_refseq": "interferon 1da1; interferon beta precursor", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); cerebral infarction (Disease Ontology:DOID:3526); proteinuria (Disease Ontology:DOID:576); retinoblastoma (Disease Ontology:DOID:768)", "pathway": " (mmu:15977); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10708458;12707359;14597717;14623278;1505514;23872679;26451483;2726460;3221389;3360010;6688252;7473712", "class_list": "", "function": "Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:10708458, PubMed:23872679). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (PubMed:23872679). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (PubMed:10708458, PubMed:14597717). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (PubMed:26451483). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (PubMed:14597717)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 9, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding;GO:0008811 chloramphenicol O-acetyltransferase activity;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:1904465 negative regulation of matrix metallopeptidase secretion;GO:0002312 B cell activation involved in immune response;GO:0071359 cellular response to dsRNA;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P01575-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01749-1", "uniprot_id": "HVM05_MOUSE", "mass": 13016.0, "length": 117, "protein_name": "Ig heavy chain V region 3", "gene_name": "Ighv1-61", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ighv1-61; Igh-VJ558", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "6788376", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, 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"ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01749-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01756-1", "uniprot_id": "HVM12_MOUSE", "mass": 12983.0, "length": 117, "protein_name": "Ig heavy chain V region MOPC 104E", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region MOPC 104E", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6816276", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P01756-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01757-1", "uniprot_id": "HVM13_MOUSE", "mass": 13025.0, "length": 117, "protein_name": "Ig heavy chain V region J558", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region J558", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6765983", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, 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"ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01757-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01759-1", "uniprot_id": "HVM15_MOUSE", "mass": 15078.0, "length": 136, "protein_name": "Ig heavy chain V region BCL1", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region BCL1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "35820727;6806821", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, 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Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VQ5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030878 thyroid gland development;GO:0060574 intestinal epithelial cell maturation;GO:0060435 bronchiole development;GO:0060535 trachea cartilage morphogenesis;GO:0060638 mesenchymal-epithelial cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09021-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09023-1", "uniprot_id": "HXB6_MOUSE", "mass": 25310.0, "length": 224, "protein_name": "Homeobox protein Hox-B6", "gene_name": "Hoxb6", "organism": "Mouse", "refseq_name": "homeobox protein Hox-B6", "refseq_ac": "NP_032295", "gene_names_uniprotkb": "Hoxb6; Hox-2.2; Hoxb-6", "gene_names_refseq": "Hox-2.2; Hoxb6", "protein_names_uniprotkb": "Homeobox protein Hox-B6; Homeobox protein Hox-2.2; Homeobox protein MH-22A", "protein_names_refseq": "homeo box B6; homeobox protein Hox-2.2; homeobox protein Hox-B6; homeobox protein MH-22A", "tax_id": 10090, "disease": "", "pathway": " (mmu:15414)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10327653;1672751;21183079;2890503;2891608;2899893", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0048704 embryonic skeletal system morphogenesis;GO:0034101 erythrocyte homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09023-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09235-1", "uniprot_id": "IFNA9_MOUSE", "mass": 21684.0, "length": 190, "protein_name": "Interferon alpha-9", "gene_name": "Ifna9", "organism": "Mouse", "refseq_name": "interferon alpha-9 precursor", "refseq_ac": "NP_034637", "gene_names_uniprotkb": "Ifna9; Ifa9", "gene_names_refseq": "If1ai3; Ifa9; Ifna9", "protein_names_uniprotkb": "Interferon alpha-9; IFN-alpha-9", "protein_names_refseq": "IFN-alpha-9; interferon 1ai3; interferon alpha family, gene 9; interferon alpha-9 precursor", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); common cold (Disease Ontology:DOID:10459); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); Crimean-Congo hemorrhagic fever (Disease Ontology:DOID:12287); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:15972); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "3758677", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P09235-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09631-1", "uniprot_id": "HXA9_MOUSE", "mass": 29917.0, "length": 271, "protein_name": "Homeobox protein Hox-A9", "gene_name": "Hoxa9", "organism": "Mouse", "refseq_name": "homeobox protein Hox-A9 isoform 1", "refseq_ac": "NP_034586", "gene_names_uniprotkb": "Hoxa9; Hox-1.7; Hoxa-9", "gene_names_refseq": "D6a9; Hox-1.7; Hoxa9", "protein_names_uniprotkb": "Homeobox protein Hox-A9; Homeobox protein Hox-1.7", "protein_names_refseq": "homeo box A9; homeobox protein Hox-1.7; homeobox protein Hox-A9 isoform 1; homeobox protein Hox-A9", "tax_id": 10090, "disease": "", "pathway": " (mmu:15405)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15082777;15657436;2891029;9524228", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cell surface at sites of inflammation (By similarity). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (PubMed:15657436)., [UniProtKB, UniProtKB, PubMed]; This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of similar genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important for hematopoeisis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70154;O70155", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09631-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C1T1-1", "uniprot_id": "HXB2_MOUSE", "mass": 38096.0, "length": 354, "protein_name": "Homeobox protein Hox-B2", "gene_name": "Hoxb2", "organism": "Mouse", "refseq_name": "homeobox protein Hox-B2", "refseq_ac": "NP_598793", "gene_names_uniprotkb": "Hoxb2; Hox-2.8", "gene_names_refseq": "Hox-2.8; Hoxb2; Hoxbes2", "protein_names_uniprotkb": "Homeobox protein Hox-B2; Homeobox protein Hox-2.8", "protein_names_refseq": "homeo box B2; homeobox protein Hox-2.8; homeobox protein Hox-B2", "tax_id": 10090, "disease": "", "pathway": " (mmu:103889)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16458891;8093858", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A739;B9EHW9", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021569 rhombomere 3 development;GO:0021570 rhombomere 4 development;GO:0048857 neural nucleus development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C1T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10630-1", "uniprot_id": "IF4A2_MOUSE", "mass": 46402.0, "length": 407, "protein_name": "Eukaryotic initiation factor 4A-II", "gene_name": "Eif4a2", "organism": "Mouse", "refseq_name": "eukaryotic initiation factor 4A-II isoform b", "refseq_ac": "NP_001116509", "gene_names_uniprotkb": "Eif4a2; Ddx2b", "gene_names_refseq": "4833432N07Rik; BM-010; Ddx2b; Eif4a2; Eif4; eIF-4A-II; eIF4A-II", "protein_names_uniprotkb": "Eukaryotic initiation factor 4A-II; 3.6.4.13; ATP-dependent RNA helicase eIF4A-2; eIF-4A-II; eIF4A-II", "protein_names_refseq": "ATP-dependent RNA helicase eIF4A-2; eukaryotic initiation factor 4A-II isoform b; eukaryotic initiation factor 4A-II", "tax_id": 10090, "disease": "neurodevelopmental disorder with hypotonia and speech delay (Disease Ontology:DOID:0070512)", "pathway": " (mmu:13682); (R-MMU-1169408); (R-MMU-156827); (R-MMU-429947); (R-MMU-72649); (R-MMU-72662); (R-MMU-72702); (R-MMU-72706)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "21750661;30084848;3046931;33300544;34428180;9092667", "class_list": "", "function": "ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon., [UniProtKB]; RNA helicase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61513;Q61514", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.1.13.4;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3;3.4.19.12;3.6.5.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003743 translation initiation factor activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1900260 negative regulation of RNA-dependent RNA polymerase activity;GO:0002183 cytoplasmic translational initiation;GO:1990830 cellular response to leukemia inhibitory factor;GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16297-1", "uniprot_id": "IL2RB_MOUSE", "mass": 60539.0, "length": 539, "protein_name": "Interleukin-2 receptor subunit beta", "gene_name": "Il2rb", "organism": "Mouse", "refseq_name": "interleukin-2 receptor subunit beta precursor", "refseq_ac": "NP_032394", "gene_names_uniprotkb": "Il2rb", "gene_names_refseq": "CD122; IL-15Rbeta; IL15Rbeta; Il-2/15Rbeta; Il-2Rbeta; Il2rb; p70", "protein_names_uniprotkb": "Interleukin-2 receptor subunit beta; High affinity IL-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; p70-75", "protein_names_refseq": "IL-15 receptor beta chain; IL-2 receptor beta chain; IL-2 receptor subunit beta; IL-2/15 receptor-beta; IL-2R subunit beta; IL-2RB; high affinity IL-2 receptor subunit beta; interleukin-2 receptor subunit beta precursor; interleukin-2 receptor subunit beta; p70-75", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); immunodeficiency 63 (Disease Ontology:DOID:0111997); hepatitis B (Disease Ontology:DOID:2043); asthma (Disease Ontology:DOID:2841); myasthenia gravis (Disease Ontology:DOID:437); visceral leishmaniasis (Disease Ontology:DOID:9146)", "pathway": " (mmu:16185); (R-MMU-5673001); (R-MMU-8983432); (R-MMU-9020558); (R-MMU-912526)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10671200;11801660;17675186;2155425", "class_list": "", "function": "Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity)., [UniProtKB, UniProtKB]; The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZT2", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0004911 interleukin-2 receptor activity;GO:0019976 interleukin-2 binding;GO:0042010 interleukin-15 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0005893 interleukin-2 receptor complex;GO:1905543 interleukin-15 receptor complex", "go_biological_process": "GO:0038110 interleukin-2-mediated signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0050766 positive regulation of phagocytosis;GO:0019221 cytokine-mediated signaling pathway;GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P16297-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16627-1", "uniprot_id": "HS71L_MOUSE", "mass": 70637.0, "length": 641, "protein_name": "Heat shock 70 kDa protein 1-like", "gene_name": "Hspa1l", "organism": "Mouse", "refseq_name": "heat shock 70 kDa protein 1-like", "refseq_ac": "NP_038586", "gene_names_uniprotkb": "Hspa1l; Hsc70t", "gene_names_refseq": "Hsc70t; Hspa1l; Msh5", "protein_names_uniprotkb": "Heat shock 70 kDa protein 1-like; Heat shock 70 kDa protein 1L; Heat shock 70 kDa-like protein 1; Spermatid-specific heat shock protein 70", "protein_names_refseq": "heat shock 70 kDa protein 1-like; heat shock 70 kDa protein 1L; heat shock 70 kDa-like protein 1; heat shock 70kDa protein 1-like; heat shock protein cognate 70, testis; heat shock-related protein hsc70t; inducible heat shock protein 70; spermatid-specific heat shock protein 70", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); pneumoconiosis (Disease Ontology:DOID:10316); uveitis (Disease Ontology:DOID:13141); Kawasaki disease (Disease Ontology:DOID:13378); major depressive disorder (Disease Ontology:DOID:1470); schizophrenia (Disease Ontology:DOID:5419); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:15482); (R-MMU-3371453); (R-MMU-3371497); (R-MMU-3371568); (R-MMU-3371571); (R-MMU-9833482)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;14656967;2302214;31642047;33742129;34887587;37749267;39627609;39927985;41018975;8026864;9685725", "class_list": "", "function": "A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria., [UniProtKB, UniProtKB]; These results describe a novel signaling pathway by which HspA1L activity is enhanced in response to hyperthermia during spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88686;Q61693", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0044297 cell body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007339 binding of sperm to zona pellucida;GO:0030154 cell differentiation;GO:1903955 positive regulation of protein targeting to mitochondrion;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P16627-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16872-1", "uniprot_id": "IL7RA_MOUSE", "mass": 51605.0, "length": 459, "protein_name": "Interleukin-7 receptor subunit alpha", "gene_name": "Il7r", "organism": "Mouse", "refseq_name": "interleukin-7 receptor subunit alpha isoform 1 precursor", "refseq_ac": "NP_032398", "gene_names_uniprotkb": "Il7r", "gene_names_refseq": "CD127; IL-7Ralpha; Il7r", "protein_names_uniprotkb": "Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA", "protein_names_refseq": "IL-7 receptor alpha chain; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; interleukin 7 receptor alpha chain; interleukin-7 receptor subunit alpha isoform 1 precursor; interleukin-7 receptor subunit alpha", "tax_id": 10090, "disease": "severe combined immunodeficiency 104 (Disease Ontology:DOID:0090014); stomach cancer (Disease Ontology:DOID:10534); colon cancer (Disease Ontology:DOID:219); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); severe combined immunodeficiency (Disease Ontology:DOID:627); malignant pleural mesothelioma (Disease Ontology:DOID:7474)", "pathway": " (mmu:16197); (R-MMU-1266695); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10556186;17602185;17675186;19144319;2038316;21750661;2317865;24632570;32152506", "class_list": "", "function": "Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]., [RefSeq]; Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0C1", "ec_number_list": "", "go_molecular_function": "GO:0004917 interleukin-7 receptor activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0019725 cellular homeostasis;GO:0050830 defense response to Gram-positive bacterium;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P16872-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17879-1", "uniprot_id": "HS71B_MOUSE", "mass": 70176.0, "length": 642, "protein_name": "Heat shock 70 kDa protein 1B", "gene_name": "Hspa1b", "organism": "Mouse", "refseq_name": "heat shock 70 kDa protein 1B", "refseq_ac": "NP_034608", "gene_names_uniprotkb": "Hspa1b; Hcp70.1; Hsp70-1; Hsp70a1; Hspa1", "gene_names_refseq": "HSP70B1; Hsp70-1; Hsp70.1; Hsp70; Hspa1b; hsp68", "protein_names_uniprotkb": "Heat shock 70 kDa protein 1B; HSP70.1; Heat shock 70 kDa protein 1", "protein_names_refseq": "68 kDa heat shock protein; heat shock 70 kDa protein 1B; heat shock 70 kDa protein 1; heat shock 70kDa protein 1B; heat shock protein 1B; heat shock protein 70.1; heat shock protein, 70 kDa 1", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); lymphoma (Disease Ontology:DOID:0060058); congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); urinary tract infection (Disease Ontology:DOID:0080784); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); graft-versus-host disease (Disease Ontology:DOID:0081267); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); toxic shock syndrome (Disease Ontology:DOID:14115); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352); senile cataract (Disease Ontology:DOID:9669); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15511); (R-MMU-3371453); (R-MMU-3371497); (R-MMU-3371568); (R-MMU-3371571); (R-MMU-450408); (R-MMU-6798695); (R-MMU-9833482); (R-MMU-9841251)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;14656967;17478420;19516020;2332169;23973223;37298493", "class_list": "", "function": "Heat Shock Protein 70 Is Involved in the Efficiency of Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion Injury by Modulating Mitochondrial Functions. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 2, "disease_count": 16, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61689;Q925V6", "ec_number_list": "", "go_molecular_function": "GO:0055131 C3HC4-type RING finger domain binding;GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005813 centrosome", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0007339 binding of sperm to zona pellucida;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P17879-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18524-1", "uniprot_id": "HVM53_MOUSE", "mass": 12866.0, "length": 117, "protein_name": "Ig heavy chain V region RF", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region RF", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2499654;35984892", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18524-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18525-1", "uniprot_id": "HVM54_MOUSE", "mass": 12872.0, "length": 117, "protein_name": "Ig heavy chain V region 5-84", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region 5-84", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2499654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, 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These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is expressed in rhombomere 2 and is important for hindbrain formation in the early embryo. 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Gly96; Iex1", "gene_names_refseq": "IEX-1; Ier3; cI-3; gly96", "protein_names_uniprotkb": "Radiation-inducible immediate-early gene IEX-1; Immediate early protein GLY96; Immediate early response 3 protein", "protein_names_refseq": "cAMP inducible gene 3; immediate early protein GLY96; immediate early response 3 protein; radiation-inducible immediate-early gene IEX-1", "tax_id": 10090, "disease": "T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312)", "pathway": " (mmu:15937); (R-MMU-6811558)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14644419;21183079;22565310;30373431;8437864", "class_list": "", "function": "In this article, we reviewed the findings in IEX-1 knockout mice from our laboratory and others and primarily focused on the roles of IEX-1 in cardiovascular and metabolic dis, [RefSeq, PubMed]; May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJY1;Q91VZ5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0046822 regulation of nucleocytoplasmic transport;GO:0050728 negative regulation of inflammatory response;GO:0006974 DNA damage response;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P46694-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47876-1", "uniprot_id": "IBP1_MOUSE", "mass": 29570.0, "length": 272, "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "Igfbp1", "organism": "Mouse", "refseq_name": "insulin-like growth factor-binding protein 1 precursor", "refseq_ac": "NP_032367", "gene_names_uniprotkb": "Igfbp1; Igfbp-1", "gene_names_refseq": "Igfbp1", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1", "protein_names_refseq": "IBP-1; IGF-binding protein 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1 PRECURSOR (IGFBP-1) (IBP-1) (IGF-BINDING PROTEIN 1); insulin-like growth factor-binding protein 1 precursor", "tax_id": 10090, "disease": "diabetic angiopathy (Disease Ontology:DOID:11713); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:16006); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "36326689;36825684;37296072;7509771;7529732", "class_list": "", "function": "HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene., [RefSeq, PubMed]; IGFBP1 Sustains Cell Survival during Spatially-Confined Migration and Promotes Tumor Metastasis., [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (By similarity). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SVY8;Q61732", "ec_number_list": "", "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0032868 response to insulin;GO:0008286 insulin receptor signaling pathway;GO:0042246 tissue regeneration;GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P47876-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47878-1", "uniprot_id": "IBP3_MOUSE", "mass": 31687.0, "length": 292, "protein_name": "Insulin-like growth factor-binding protein 3", "gene_name": "Igfbp3", "organism": "Mouse", "refseq_name": "insulin-like growth factor-binding protein 3 precursor", "refseq_ac": "NP_032369", "gene_names_uniprotkb": "Igfbp3; Igfbp-3", "gene_names_refseq": "IGFBP-3; IGgfbp3; Igfbp3", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3", "protein_names_refseq": "IBP-3; IGF-binding protein 3; insulin-like growth factor-binding protein 3 precursor", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); prostate cancer (Disease Ontology:DOID:10283); tonsillitis (Disease Ontology:DOID:10456); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); osteoporosis (Disease Ontology:DOID:11476); beta thalassemia (Disease Ontology:DOID:12241); acoustic neuroma (Disease Ontology:DOID:12689); retinopathy of prematurity (Disease Ontology:DOID:13025); Down syndrome (Disease Ontology:DOID:14250); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); ichthyosis (Disease Ontology:DOID:1697); McCune Albright syndrome (Disease Ontology:DOID:1858); impotence (Disease Ontology:DOID:1875); arteriosclerosis (Disease Ontology:DOID:2349); transitional cell carcinoma (Disease Ontology:DOID:2671); high grade glioma (Disease Ontology:DOID:3070); Turner syndrome (Disease Ontology:DOID:3491); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); epidermolysis bullosa dystrophica (Disease Ontology:DOID:4959); ankylosing spondylitis (Disease Ontology:DOID:7147); osteoarthritis (Disease Ontology:DOID:8398); myeloid leukemia (Disease Ontology:DOID:8692); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); Barrett's esophagus (Disease Ontology:DOID:9206); ornithine carbamoyltransferase deficiency (Disease Ontology:DOID:9271); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16009); (R-MMU-381426); (R-MMU-6803211); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "19952275;38432050;38838451;7529732", "class_list": "", "function": "IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis., [UniProtKB, UniProtKB]; The effect of IGFBP3 gene knockout by the CRISPR/Cas9 system on the IGF-1 pathway in murine cells., [RefSeq, PubMed]; Unraveling IGFBP3-mediated m6A modification in fracture healing., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6PE62", "ec_number_list": "", "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0001968 fibronectin binding;GO:0008160 protein tyrosine phosphatase activator activity;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0042567 insulin-like growth factor ternary complex;GO:0000792 heterochromatin;GO:0031091 platelet alpha granule", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0040008 regulation of growth;GO:0043065 positive regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P47878-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47880-1", "uniprot_id": "IBP6_MOUSE", "mass": 25347.0, "length": 238, "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "Igfbp6", "organism": "Mouse", "refseq_name": "insulin-like growth factor-binding protein 6 precursor", "refseq_ac": "NP_032370", "gene_names_uniprotkb": "Igfbp6; Igfbp-6", "gene_names_refseq": "IGFBP-6; Igfbp6", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 6; IBP-6; IGF-binding protein 6; IGFBP-6", "protein_names_refseq": "IBP-6; IGF-binding protein 6; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 6 PRECURSOR (IGFBP-6) (IBP-6) (IGF-BINDING PROTEIN 6); insulin-like growth factor-binding protein 6 precursor", "tax_id": 10090, "disease": "leiomyoma (Disease Ontology:DOID:127); breast cancer (Disease Ontology:DOID:1612); in situ carcinoma (Disease Ontology:DOID:8719); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16012); (R-MMU-381426)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18824213;31219806;7529732", "class_list": "", "function": "IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91X24", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0001968 fibronectin binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0042568 insulin-like growth factor binary complex", "go_biological_process": "GO:0016477 cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0032874 positive regulation of stress-activated MAPK cascade;GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P47880-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48441-1", "uniprot_id": "IDUA_MOUSE", "mass": 71254.0, "length": 634, "protein_name": "Alpha-L-iduronidase", "gene_name": "Idua", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Idua", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-L-iduronidase; 3.2.1.76", "protein_names_refseq": "", "tax_id": 10090, "disease": "Scheie syndrome (Disease Ontology:DOID:0060222); mucopolysaccharidosis Ih/s (Disease Ontology:DOID:0111389); mucopolysaccharidosis Ih (Disease Ontology:DOID:0111390); otitis media (Disease Ontology:DOID:10754); gastric ulcer (Disease Ontology:DOID:10808); mucopolysaccharidosis I (Disease Ontology:DOID:12802)", "pathway": " (R-MMU-2024096); (R-MMU-2024101)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28011936;30084848;30899004;34428180;35984892;37828378;7698753", "class_list": "glycogene;glycosylhydrolase", "function": "Lysosomal hydrolase responsible for the degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 6, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "E9QM17", "ec_number_list": "3.2.1.76", "go_molecular_function": "GO:0003940 L-iduronidase activity;GO:0005102 signaling receptor binding;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0030209 dermatan sulfate proteoglycan catabolic process;GO:0007613 memory;GO:0007626 locomotory behavior;GO:0008344 adult locomotory behavior;GO:0008542 visual learning", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P48441-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70217-1", "uniprot_id": "HXD13_MOUSE", "mass": 35889.0, "length": 339, "protein_name": "Homeobox protein Hox-D13", "gene_name": "Hoxd13", "organism": "Mouse", "refseq_name": "homeobox protein Hox-D13", "refseq_ac": "NP_032301", "gene_names_uniprotkb": "Hoxd13; Hox-4.8", "gene_names_refseq": "Hox-4.8; Hoxd13; spdh", "protein_names_uniprotkb": "Homeobox protein Hox-D13; Homeobox protein Hox-4.8", "protein_names_refseq": "homeo box D13; homeobox protein Hox-4.8; homeobox protein Hox-D13", "tax_id": 10090, "disease": "brachydactyly (Disease Ontology:DOID:0050581); brachydactyly-syndactyly syndrome (Disease Ontology:DOID:0050689); synpolydactyly (Disease Ontology:DOID:0060242); brachydactyly type A4 (Disease Ontology:DOID:0110967); brachydactyly type D (Disease Ontology:DOID:0110971); brachydactyly type E1 (Disease Ontology:DOID:0110972); syndactyly type 5 (Disease Ontology:DOID:0111819); hypospadias (Disease Ontology:DOID:10892); cryptorchidism (Disease Ontology:DOID:11383); clubfoot (Disease Ontology:DOID:11836)", "pathway": " (mmu:15433)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1685889;21913724;23995701;28528544;8978698", "class_list": "", "function": "Sequence-specific transcription factor that binds gene promoters and activates their transcription (PubMed:23995701). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ASM5;Q2VPB0;Q2VPB1;Q64177", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0060602 branch elongation of an epithelium;GO:0048619 embryonic hindgut morphogenesis;GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70217-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70321-1", "uniprot_id": "HXB13_MOUSE", "mass": 30963.0, "length": 286, "protein_name": "Homeobox protein Hox-B13", "gene_name": "Hoxb13", "organism": "Mouse", "refseq_name": "homeobox protein Hox-B13", "refseq_ac": "NP_032293", "gene_names_uniprotkb": "Hoxb13", "gene_names_refseq": "Hoxb13", "protein_names_uniprotkb": "Homeobox protein Hox-B13", "protein_names_refseq": "homeo box B13; homeobox protein Hox-B13", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); endometrial cancer (Disease Ontology:DOID:1380); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:15408)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25428506;37409967;37850574;8756292", "class_list": "", "function": "Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer., [RefSeq, PubMed]; Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its Activity and Oncogenic Function in Prostate Cancer., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y12", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008327 methyl-CpG binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0060743 epithelial cell maturation involved in prostate gland development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70404-1", "uniprot_id": "IDHG1_MOUSE", "mass": 42785.0, "length": 393, "protein_name": "Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial", "gene_name": "Idh3g", "organism": "Mouse", "refseq_name": "isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 1 precursor", "refseq_ac": "NP_032349", "gene_names_uniprotkb": "Idh3g", "gene_names_refseq": "Idh3g", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial; Isocitric dehydrogenase subunit gamma; NAD(+)-specific ICDH subunit gamma", "protein_names_refseq": "NAD(+)-specific ICDH subunit gamma; isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 1 precursor; isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial; isocitric dehydrogenase subunit gamma", "tax_id": 10090, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709)", "pathway": " (mmu:15929); (R-MMU-71403)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16452087;23576753;23806337;33300544;36288343;37507081;37955350;9286695", "class_list": "", "function": "BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification., [RefSeq, PubMed]; Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0051287 NAD binding;GO:0004449 isocitrate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0001917 photoreceptor inner segment;GO:0045242 isocitrate dehydrogenase complex (NAD+)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70404-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81183-1", "uniprot_id": "IKZF2_MOUSE", "mass": 59401.0, "length": 526, "protein_name": "Zinc finger protein Helios", "gene_name": "Ikzf2", "organism": "Mouse", "refseq_name": "zinc finger protein Helios isoform 2", "refseq_ac": "NP_035900", "gene_names_uniprotkb": "Ikzf2; Helios; Zfpn1a2; Znfn1a2", "gene_names_refseq": "A730095J18Rik; Helios; Ikzf2; Zfpn1a2; Znfn1a2", "protein_names_uniprotkb": "Zinc finger protein Helios; Ikaros family zinc finger protein 2", "protein_names_refseq": "ikaros family zinc finger protein 2; zinc finger protein Helios isoform 2; zinc finger protein Helios; zinc finger protein, subfamily 1A, 2 (Helios)", "tax_id": 10090, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:22779); (R-MMU-9940951)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16148093;17110463;19620299;21183079;21750661;23275607;26472910;30084848;30464345;9512513", "class_list": "", "function": "Results demonstrate a vital function for Helios in maintaining normal homeostasis of developing T cells and formally show that non-DNA-binding isoforms of Helios are lymphomagenic if aberrantly expressed within the T-cell lineage, [RefSeq, PubMed]; Silencing of Helios is critical for normal B cell function, [RefSeq, PubMed]; Transcription factor, which stabilizes the noninflammatory phenotype of regulatory T cells (Tregs). Therefore plays a crucial role in self-tolerance (PubMed:26472910). May possibly act via STAT5-mediated signaling (PubMed:26472910). Binds IL2 promoter and represses its transcription, possibly by epigenetic silencing, inducing deacetylation of core histones in the IL2 promoter (PubMed:23275607). In Tregs, required for FOXP3 recruitment to the IL2 promoter (PubMed:23275607). Required for outer hair cells maturation and, consequently, for hearing (PubMed:30464345)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8A3", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007605 sensory perception of sound;GO:0099129 cochlear outer hair cell electromotile response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P81183-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83891-1", "uniprot_id": "IMPL_MOUSE", "mass": 2217.0, "length": 20, "protein_name": "Implantin", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Implantin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P83891-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04998-1", "uniprot_id": "INHBA_MOUSE", "mass": 47392.0, "length": 424, "protein_name": "Inhibin beta A chain", "gene_name": "Inhba", "organism": "Mouse", "refseq_name": "inhibin beta A chain preproprotein", "refseq_ac": "NP_032406", "gene_names_uniprotkb": "Inhba", "gene_names_refseq": "Inhba", "protein_names_uniprotkb": "Inhibin beta A chain; Activin beta-A chain", "protein_names_refseq": "activin A; activin beta-A chain; inhibin beta A chain preproprotein; inhibin beta A chain", "tax_id": 10090, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); gestational diabetes (Disease Ontology:DOID:11714); prolapse of female genital organ (Disease Ontology:DOID:1284); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:16323); (R-MMU-1502540); (R-MMU-201451); (R-MMU-209822); (R-MMU-2473224); (R-MMU-9839406)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "2133547;37828378;7885473;8330535", "class_list": "glycogene", "function": "Activin A is a homodimer of INHBA that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis (PubMed:7885473). Signals through type I (such as ACVR1B or ACVR1C) and type II receptors (such as ACVR2A, ACVR2B or BMPR2) which, upon ligand binding, phosphorylate SMAD2 and SMAD3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and modulate gene expression. Can also activate alternative non-canonical intracellular signaling pathways including the p38 MAPK, extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinases (JNKs) to modulate cell migration and differentiation. Alternatively, promotes osteoblastic differentiation via ACVRL1-SMAD1/5/9 pathway. In addition, can engage the type I receptor ACVR1 to form an ACVR1-activin A-type II receptor non-signaling complex (NSC) that renders receptors unavailable for engagement with BMPs, hence resulting in an apparent inhibition of ACVR1-mediated BMP signaling., [UniProtKB, UniProtKB]; Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor., [UniProtKB, UniProtKB]; Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition., [UniProtKB, UniProtKB]; This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Homozygous knockout mice for this gene lack whiskers and exhibit tooth and palate defects, leading to neonatal lethality. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070699 type II activin receptor binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0043509 activin A complex;GO:0043512 inhibin A complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0046880 regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0001934 positive regulation of protein phosphorylation;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q04998-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07079-1", "uniprot_id": "IBP5_MOUSE", "mass": 30372.0, "length": 271, "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "Igfbp5", "organism": "Mouse", "refseq_name": "insulin-like growth factor-binding protein 5 precursor", "refseq_ac": "NP_034648", "gene_names_uniprotkb": "Igfbp5; Igfbp-5", "gene_names_refseq": "IGFBP-5P; IGFBP-5; Igfbp5", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5", "protein_names_refseq": "IBP-5; IGF-binding protein 5; insulin-like growth factor-binding protein 5 precursor", "tax_id": 10090, "disease": "pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (mmu:16011); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15010534;24120850;25428506;26495903;26854565;7518410;7529732;7693664", "class_list": "", "function": "Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells (By similarity). Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (PubMed:24120850). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs. Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0001968 fibronectin binding;GO:0048018 receptor ligand activity;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042567 insulin-like growth factor ternary complex;GO:0016942 insulin-like growth factor binding protein complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0035556 intracellular signal transduction;GO:0040008 regulation of growth;GO:0048286 lung alveolus development;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q07079-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U4N7-1", "uniprot_id": "IGFR1_MOUSE", "mass": 37172.0, "length": 345, "protein_name": "IGF-like family receptor 1", "gene_name": "Igflr1", "organism": "Mouse", "refseq_name": "IGF-like family receptor 1 precursor", "refseq_ac": "NP_663555", "gene_names_uniprotkb": "Igflr1; Tmem149", "gene_names_refseq": "F630003I17Rik; Igflr1; Tmem149", "protein_names_uniprotkb": "IGF-like family receptor 1; Transmembrane protein 149", "protein_names_refseq": "IGF-like family receptor 1 precursor; U2 small nuclear RNA auxiliary factor 1-like 4; transmembrane protein 149", "tax_id": 10090, "disease": "", "pathway": " (mmu:101883)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21454693;21750661", "class_list": "", "function": "Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1., [RefSeq, PubMed]; Probable cell membrane receptor for the IGF-like family protein IGFL., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VE58", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U4N7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4VK74-1", "uniprot_id": "IFNL2_MOUSE", "mass": 21740.0, "length": 193, "protein_name": "Interferon lambda-2", "gene_name": "Ifnl2", "organism": "Mouse", "refseq_name": "interferon lambda-2 precursor", "refseq_ac": "NP_001019844", "gene_names_uniprotkb": "Ifnl2; Il28a", "gene_names_refseq": "EG330496; IL-28A; If1ia1; Ifnl2; Il28a", "protein_names_uniprotkb": "Interferon lambda-2; IFN-lambda-2; IL-28A; Interleukin-28A", "protein_names_refseq": "IFN-lambda-2; IFN-lambda2; interferon 1ia1; interferon lambda-2 precursor; interferon-lambda2; interleukin-28A", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); dengue disease (Disease Ontology:DOID:12205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); thrombocytopenia (Disease Ontology:DOID:1588); hepatitis C (Disease Ontology:DOID:1883); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); subacute sclerosing panencephalitis (Disease Ontology:DOID:8970)", "pathway": " (mmu:330496); (R-MMU-8854691)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15914836;16618774;18250457;20712453;21518880;24532585;24751921;31462571;38265281", "class_list": "", "function": "Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Data indicate that IPS-1-dependent pathway plays a crucial role in type III IFN production by CD8(+) dendritic cells (DCs) and hepatocytes in response to hepatitis C virus (HCV), leading to cytoplasmic antiviral protein expressions., [RefSeq, PubMed]; Interleukin 28A aggravates Con A-induced acute liver injury by promoting the recruitment of M1 macrophages., [RefSeq, PubMed]; Results support the idea of an exclusive role for known type III interferon cytokines in signaling via IFNLR to mediate antiviral effects at mucosal surfaces. These findings emphasize the importance of type III interferons in regulation of a variety of viral pathogens and provide important genetic evidence to support our understanding of the ligand-receptor interactions in this pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2S2", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0032003 interleukin-28 receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0032002 interleukin-28 receptor complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0050778 positive regulation of immune response;GO:0002385 mucosal immune response;GO:0007259 cell surface receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q4VK74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6B9Z0-1", "uniprot_id": "IGFL_MOUSE", "mass": 15667.0, "length": 140, "protein_name": "Insulin growth factor-like family member", "gene_name": "Igfl", "organism": "Mouse", "refseq_name": "insulin growth factor-like family member precursor", "refseq_ac": "NP_001003393", "gene_names_uniprotkb": "Igfl; Gm580; Igfl3; mIgfl", "gene_names_refseq": "Gm580; Igfl3; Igfl; Rprc483", "protein_names_uniprotkb": "Insulin growth factor-like family member", "protein_names_refseq": "insulin growth factor-like family member precursor; insulin growth factor-like family member", "tax_id": 10090, "disease": "", "pathway": " (mmu:232925)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16890402;21454693;37603122", "class_list": "", "function": "Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis., [RefSeq, PubMed]; Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1., [RefSeq, PubMed]; Probable ligand of the IGFLR1 cell membrane receptor., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6B9Z0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PCM2-1", "uniprot_id": "INT6_MOUSE", "mass": 99661.0, "length": 883, "protein_name": "Integrator complex subunit 6", "gene_name": "Ints6", "organism": "Mouse", "refseq_name": "integrator complex subunit 6", "refseq_ac": "NP_032741", "gene_names_uniprotkb": "Ints6; Dbi1", "gene_names_refseq": "2900075H24Rik; DICE1; Ddx26; HDB; Ints6; Notch2l", "protein_names_uniprotkb": "Integrator complex subunit 6; DBI-1; Int6", "protein_names_refseq": "DBI-1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26; int6; integrator complex subunit 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:18130); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22872234;29237092;31219806;34428180;9473344", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA02;Q61204;Q6PDL7;Q8BQZ7", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0015629 actin cytoskeleton;GO:0000785 chromatin;GO:0032039 integrator complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0071168 protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PCM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNR6-1", "uniprot_id": "IGS21_MOUSE", "mass": 51937.0, "length": 468, "protein_name": "Immunoglobulin superfamily member 21", "gene_name": "Igsf21", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily member 21 precursor", "refseq_ac": "NP_941012", "gene_names_uniprotkb": "Igsf21", "gene_names_refseq": "Gm141; Igsf21", "protein_names_uniprotkb": "Immunoglobulin superfamily member 21; IgSF21", "protein_names_refseq": "immunoglobin superfamily, member 21; immunoglobulin superfamily member 21 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:230868)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;28864826;30899004;33300544", "class_list": "", "function": "IgSF21 interacts with neurexin2alpha to induce presynaptic differentiation of inhibitory synapses, and mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission Publication Status: Online-Only, [RefSeq, PubMed]; Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0009897 external side of plasma membrane;GO:0042734 presynaptic membrane;GO:0060077 inhibitory synapse", "go_biological_process": "GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:0060074 synapse maturation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q7TNR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQA1-1", "uniprot_id": "IGSF1_MOUSE", "mass": 147010.0, "length": 1317, "protein_name": "Immunoglobulin superfamily member 1", "gene_name": "Igsf1", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily member 1 isoform long precursor", "refseq_ac": "NP_808259", "gene_names_uniprotkb": "Igsf1; Kiaa0364", "gene_names_refseq": "5330413N23; 5530402E03; Igsf1; InhBP/p120; mKIAA0364", "protein_names_uniprotkb": "Immunoglobulin superfamily member 1; IgSF1; InhBP; Inhibin-binding protein", "protein_names_refseq": "betaglycan and inhibin binding protein; immunoglobulin superfamily member 1 isoform long precursor; inhBP; inhibin-binding protein", "tax_id": 10090, "disease": "IGSF1 deficiency syndrome (Disease Ontology:DOID:0111140)", "pathway": " (mmu:209268)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12832474;23143598;28324000;28686733;30899004;33300544;34203471;35708735", "class_list": "", "function": "Contrary to earlier predictions, neither the murine nor rat IGSF1-2 is secreted from heterologous or homologous cells. In addition, neither protein associates with the plasma membrane. Rather, IGSF1-2 appears to be retained in the endoplasmic reticulum. Publication Status: Online-Only, [RefSeq, PubMed]; IGSF1 Deficiency Leads to Reduced TSH Production Independent of Alterations in Thyroid Hormone Action in Male Mice., [RefSeq, PubMed]; Igsf1-deficient males exhibit normal serum TSH levels as well as normal numbers of TSH-expressing thyrotropes. However, pituitary expression of the TSH subunit genes and TSH protein content are reduced, as is expression of the receptor for thyrotropin-releasing hormone (TRH, [RefSeq, PubMed]; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQD0;Q7TQ99;Q7TQA0;Q8BMN5", "ec_number_list": "", "go_molecular_function": "GO:0038102 activin receptor antagonist activity;GO:0004888 transmembrane signaling receptor activity;GO:0015026 coreceptor activity;GO:0034711 inhibin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0006355 regulation of DNA-templated transcription;GO:0032926 negative regulation of activin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q7TQA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSL0-1", "uniprot_id": "IFNK_MOUSE", "mass": 23581.0, "length": 199, "protein_name": "Interferon kappa", "gene_name": "Ifnk", "organism": "Mouse", "refseq_name": "interferon kappa precursor", "refseq_ac": "NP_954608", "gene_names_uniprotkb": "Ifnk", "gene_names_refseq": "If1fa; Ifnk", "protein_names_uniprotkb": "Interferon kappa; IFN-kappa", "protein_names_refseq": "IFN-kappa; interferon 1fa; interferon kappa precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:387510)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12759458;34364883", "class_list": "", "function": "IFN-kappa Is a Rheostat for Development of Psoriasiform Inflammation., [RefSeq, PubMed]; May play a role in the regulation of immune cell function., [UniProtKB]; Mouse IFN-kappa is expressed at low levels in peritoneal macrophages, its expression up-regulated by double-stranded RNA and IFN-gamma; transgenic mice overexpressing murine IFN-kappa in the pancreatic islets develop overt diabetes with hyperglycemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0006355 regulation of DNA-templated transcription;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TSL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80SU4-1", "uniprot_id": "IFNAD_MOUSE", "mass": 21567.0, "length": 189, "protein_name": "Interferon alpha-13", "gene_name": "Ifna13", "organism": "Mouse", "refseq_name": "interferon alpha-13 precursor", "refseq_ac": "NP_796321", "gene_names_uniprotkb": "Ifna13", "gene_names_refseq": "If1ai5; Ifna13", "protein_names_uniprotkb": "Interferon alpha-13; IFN-alpha-13", "protein_names_refseq": "IFN-alpha-13; interferon 1ai5; interferon alpha family, gene 13; interferon alpha-13 precursor", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); common cold (Disease Ontology:DOID:10459); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); Crimean-Congo hemorrhagic fever (Disease Ontology:DOID:12287); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:230396); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12930842;15233997", "class_list": "", "function": "Exhibits antiviral activity against Theiler's virus, Mengo virus and vesicular stomatitis virus. Interferons alpha stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB, PubMed]; Is transcribed constitutively, independent of viral infection and of interferon regulatory factor-7 induction, and contains two N-glycosylation sites, [RefSeq, PubMed]; Novel ifna13 was identified in mouse chromosome 4., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80SU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80V26-1", "uniprot_id": "IMPA3_MOUSE", "mass": 38616.0, "length": 356, "protein_name": "Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase", "gene_name": "Bpnt2", "organism": "Mouse", "refseq_name": "Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase", "refseq_ac": "NP_808398", "gene_names_uniprotkb": "Bpnt2; Impa3; Impad1", "gene_names_refseq": "1110001C20Rik; B230207P20; Bpnt2; IMP 3; IMPase 3; Impad1; Jaws; gPAPP", "protein_names_uniprotkb": "Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; 3'(2'), 5'-bisphosphate nucleotidase 2; 3.1.3.7; Golgi-resident PAP phosphatase; Inositol monophosphatase domain-containing protein 1; Myo-inositol monophosphatase A3; Phosphoadenosine phosphate 3'-nucleotidase; gPAPP", "protein_names_refseq": "Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; golgi-resident PAP phosphatase; inositol monophosphatase 3; inositol monophosphatase domain containing 1; inositol monophosphatase domain-containing protein 1; inositol-1(or 4)-monophosphatase 3; myo-inositol monophosphatase A3; phosphoadenosine phosphate 3'-nucleotidase", "tax_id": 10090, "disease": "chondrodysplasia with joint dislocations gPAPP type (Disease Ontology:DOID:0112224)", "pathway": " (mmu:242291); (R-MMU-156584)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;18539921;18695242;31219806;34428180;34634304;34920982", "class_list": "", "function": "Bisphosphate nucleotidase 2 (BPNT2), a molecular target of lithium, regulates chondroitin sulfation patterns in the cerebral cortex and hippocampus., [RefSeq, PubMed]; Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate (PubMed:18695242). May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (PubMed:18695242). Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4., [UniProtKB, PubMed]; Golgi plays an important role in glycosaminoglycan sulfation and define a function for gPAPP in the formation of skeletal elements derived through endochondral ossification[3'-phosphoadenosine 5'-phosphate phosphatase], [RefSeq, PubMed]; Identify JAWS as a key regulator of chondrogenesis and synovial joint positioning required for the restriction of joint formation to discrete stereotyped locations in the embryonic skeleton, [RefSeq, PubMed]; Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6P6", "ec_number_list": "3.1.3.7;3.1.3.57", "go_molecular_function": "GO:0008254 3'-nucleotidase activity;GO:0097657 3',5'-nucleotide bisphosphate phosphatase activity;GO:0046872 metal ion binding;GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0001501 skeletal system development;GO:0009791 post-embryonic development;GO:0042733 embryonic digit morphogenesis;GO:0001958 endochondral ossification;GO:0002063 chondrocyte development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80V26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKN6-1", "uniprot_id": "HS3SA_MOUSE", "mass": 43483.0, "length": 393, "protein_name": "Heparan sulfate glucosamine 3-O-sulfotransferase 3A1", "gene_name": "Hs3st3a1", "organism": "Mouse", "refseq_name": "heparan sulfate glucosamine 3-O-sulfotransferase 3A1", "refseq_ac": "NP_849201", "gene_names_uniprotkb": "Hs3st3a1; 3ost3a1; Hs3st3a", "gene_names_refseq": "3Ost3a; Hs3st3a1; Hs3st3a", "protein_names_uniprotkb": "Heparan sulfate glucosamine 3-O-sulfotransferase 3A1; 2.8.2.23; Heparan sulfate 3-O-sulfotransferase 3A1; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1", "protein_names_refseq": "heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1; heparan sulfate glucosamine 3-O-sulfotransferase 3A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15478); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "34653670;37201729", "class_list": "glycogene", "function": "3-O sulfation of syndecan-1 mediated by the sulfotransferase HS3ST3a1 enhances myeloma aggressiveness., [RefSeq, PubMed]; Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function., [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.23;2.8.2.29;2.8.2.30", "go_molecular_function": "GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0001658 branching involved in ureteric bud morphogenesis;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BKN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLY7-1", "uniprot_id": "HPS6_MOUSE", "mass": 87341.0, "length": 805, "protein_name": "BLOC-2 complex member HPS6", "gene_name": "Hps6", "organism": "Mouse", "refseq_name": "BLOC-2 complex member HPS6", "refseq_ac": "NP_789742", "gene_names_uniprotkb": "Hps6; Ru", "gene_names_refseq": "5330434M19Rik; BLOC2; Hps6; ru", "protein_names_uniprotkb": "BLOC-2 complex member HPS6; Hermansky-Pudlak syndrome 6 protein homolog; Ruby-eye protein; Ru", "protein_names_refseq": "BLOC-2 complex member HPS6; hermansky-Pudlak syndrome 6 protein homolog; ruby eye; ruby-eye protein", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome 6 (Disease Ontology:DOID:0060544); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:20170)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12548288;19010779;25189619;30710063;31219806;32614949", "class_list": "", "function": "May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (By similarity). Acts as a cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning (PubMed:25189619)., [UniProtKB, PubMed, UniProtKB]; This study analyzed the plasma lipid profiles of three HPS mutant mice, pa (Hps9 (-/-)), ru (Hps6 (-/-)), ep (Hps1 (-/-)), and wild-type (WT) mice. The findings may provide clues to explain why different HPS mutant mice exhibit distinct anti-atherosclerotic or atherogenic effects after being exposed to high-cholesterol diets. Publication Status: Online-Only, [RefSeq, PubMed]; VWF maturation and release are controlled by 2 regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWQ8;Q8BML5;Q8CIA3", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:1903232 melanosome assembly;GO:0006629 lipid metabolic process;GO:0055088 lipid homeostasis;GO:0007596 blood coagulation;GO:0060155 platelet dense granule organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BLY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BR26-1", "uniprot_id": "IFM10_MOUSE", "mass": 21555.0, "length": 201, "protein_name": "Interferon-induced transmembrane protein 10", "gene_name": "Ifitm10", "organism": "Mouse", "refseq_name": "interferon-induced transmembrane protein 10 isoform 3", "refseq_ac": "NP_001334471", "gene_names_uniprotkb": "Ifitm10", "gene_names_refseq": "6330512M04Rik; DSPA3; Ifitm10", "protein_names_uniprotkb": "Interferon-induced transmembrane protein 10; DSPA3; Dispanin subfamily A member 3", "protein_names_refseq": "CD225 family protein FLJ76511 homolog; dispanin subfamily A member 3; interferon-induced transmembrane protein 10 isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:320802)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22363774;30084848;31219806;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810P6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BR26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BU00-1", "uniprot_id": "IKZF5_MOUSE", "mass": 46400.0, "length": 419, "protein_name": "Zinc finger protein Pegasus", "gene_name": "Ikzf5", "organism": "Mouse", "refseq_name": "zinc finger protein Pegasus isoform 1", "refseq_ac": "NP_780324", "gene_names_uniprotkb": "Ikzf5; Zfpn1a5; Znfn1a5", "gene_names_refseq": "2610034F18Rik; Ikzf5; PEGASUS; Zfpn1a5", "protein_names_uniprotkb": "Zinc finger protein Pegasus; Ikaros family zinc finger protein 5", "protein_names_refseq": "ikaros family zinc finger protein 5; zinc finger protein Pegasus isoform 1; zinc finger protein Pegasus; zinc finger protein, subfamily 1A, 5", "tax_id": 10090, "disease": "thrombocytopenia (Disease Ontology:DOID:1588)", "pathway": " (mmu:67143)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;40021952", "class_list": "", "function": "Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity). Involved in megakaryocyte differentiation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U549;Q3USG0;Q8BZR5", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BU00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BV66-1", "uniprot_id": "IFI44_MOUSE", "mass": 47852.0, "length": 422, "protein_name": "Interferon-induced protein 44", "gene_name": "Ifi44", "organism": "Mouse", "refseq_name": "interferon-induced protein 44 isoform 1", "refseq_ac": "NP_598632", "gene_names_uniprotkb": "Ifi44; Mtap44", "gene_names_refseq": "A430056A10Rik; Ifi44; MTAP44; p44", "protein_names_uniprotkb": "Interferon-induced protein 44; Microtubule-associated protein 44", "protein_names_refseq": "interferon-induced protein 44 isoform 1; microtubule-associated protein 44", "tax_id": 10090, "disease": "", "pathway": " (mmu:99899); (R-MMU-9909505)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;31219806;32611756;34428180;36210013", "class_list": "", "function": "Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial Virus. Publication Status: Online-Only, [RefSeq, PubMed]; This protein aggregates to form microtubular structures., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9ER37", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006955 immune response;GO:0009617 response to bacterium;GO:0098586 cellular response to virus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BV66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVN8-1", "uniprot_id": "IDLC_MOUSE", "mass": 29680.0, "length": 258, "protein_name": "Axonemal dynein light intermediate polypeptide 1", "gene_name": "Dnali1", "organism": "Mouse", "refseq_name": "axonemal dynein light intermediate polypeptide 1", "refseq_ac": "NP_780432", "gene_names_uniprotkb": "Dnali1", "gene_names_refseq": "1700023A09Rik; Dnali1", "protein_names_uniprotkb": "Axonemal dynein light intermediate polypeptide 1; Inner dynein arm light chain, axonemal", "protein_names_refseq": "axonemal dynein light chain (hp28) homolog; axonemal dynein light intermediate polypeptide 1; inner dynein arm light chain, axonemal", "tax_id": 10090, "disease": "spermatogenic failure 83 (Disease Ontology:DOID:0070582)", "pathway": " (mmu:75563)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16496424;17971504;35820727;36792588", "class_list": "", "function": "DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath. Publication Status: Online-Only, [RefSeq, PubMed]; Dnali1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Involved in sperm flagellum assembly., [UniProtKB, PubMed]; Results describe the gene encoding the dynein axonemal light intermediate chain Dnali1, and suggest that the C-terminal part of the cytoplasmic dynein heavy chain 1 is a putative interacting polypeptide of Dnali1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0IIN3;Q147V3", "ec_number_list": "", "go_molecular_function": "GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0031514 motile cilium", "go_biological_process": "GO:0003341 cilium movement;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BVN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWD2-1", "uniprot_id": "IP6K3_MOUSE", "mass": 44418.0, "length": 396, "protein_name": "Inositol hexakisphosphate kinase 3", "gene_name": "Ip6k3", "organism": "Mouse", "refseq_name": "inositol hexakisphosphate kinase 3", "refseq_ac": "NP_766615", "gene_names_uniprotkb": "Ip6k3; Ihpk3", "gene_names_refseq": "D830007E07Rik; Ihpk3; Ip6k3", "protein_names_uniprotkb": "Inositol hexakisphosphate kinase 3; 2.7.4.21; Inositol hexaphosphate kinase 3; InsP6 kinase 3", "protein_names_refseq": "inositol hexakisphosphate kinase 3; insP6 kinase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:271424); (R-MMU-1855167)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11502751;26245967;27577108", "class_list": "", "function": "Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity). In turn, the generated InsP7 binds to the SPX domain of the XPR1 phosphate exporter to stimulate cellular phosphate export (PubMed:26245967). Regulates also synaptic disposition noncatalytically via influences upon specific cytoskeletal proteins including spectrin and alpha- and beta adducin (PubMed:26245967)., [UniProtKB, UniProtKB, PubMed]; High levels of IP6K3 mRNA were found in myotubes and muscle tissues. Expression was elevated under diabetic, fasting, and disuse conditions in mouse skeletal muscles. Ip6k3(-/-) mice had lower blood glucose, less insulin, decreased fat, lower weight, increased plasma lactate, enhanced glucose tolerance, lower glucose during an insulin tolerance test, and reduced muscle Pdk4 expression. Ip6k3 deletion extended lifespan. Publication Status: Online-Only, [RefSeq, PubMed]; IP6K3 is highly expressed in cerebellar Purkinje cells. IP6K3-deleted mice display defects of motor learning and coordination. IP6K3-null mice manifest aberrations of Purkinje cells with a diminished number of synapses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.4.21;2.7.-.-;2.7.4.-", "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0000832 inositol hexakisphosphate 5-kinase activity;GO:0000831 inositol hexakisphosphate 6-kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0040011 locomotion;GO:0046488 phosphatidylinositol metabolic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BWD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGE8-1", "uniprot_id": "IFI5A_MOUSE", "mass": 45176.0, "length": 404, "protein_name": "Interferon-activable protein 205-A", "gene_name": "Ifi205a", "organism": "Mouse", "refseq_name": "interferon-activable protein 205-A", "refseq_ac": "NP_766236", "gene_names_uniprotkb": "Ifi205a; Ifi205", "gene_names_refseq": "D3cDNA; D3; Ifi205a; Ifi205", "protein_names_uniprotkb": "Interferon-activable protein 205-A; Ifi-205-A; Interferon-inducible protein p205-A; Protein D3'", "protein_names_refseq": "ifi-205-A; interferon-activable protein 205-A; interferon-inducible protein p205-A; protein D3'", "tax_id": 10090, "disease": "", "pathway": " (mmu:226695); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12809674;16458891;24859602;28679751;34428180", "class_list": "", "function": "Findings show that the mouse ALR IFI205 senses self DNA derived from retrotransposons in the cytoplasm of macrophages and activates the type I IFN signaling pathway via STING; suggest that ALRs, including IFI205 and AIM2, function together with cGAS as positive and negative regulators of the innate immune response to cytosolic self DNAs Publication Status: Online-Only, [RefSeq, PubMed]; May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways (By similarity)., [UniProtKB]; P205 induces growth arrest by interaction with multiple transcription factors that regulate the cell cycle, including but not entirely dependent on the Rb- and p53-mediated pathways of growth inhibition, [RefSeq, PubMed]; This study aimed to determine whether p205 is involved in adipogenesis of mouse adipose-derived stem cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYE7", "ec_number_list": "", "go_molecular_function": "GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0002218 activation of innate immune response;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CGE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGK5-1", "uniprot_id": "INLR1_MOUSE", "mass": 59976.0, "length": 535, "protein_name": "Interferon lambda receptor 1", "gene_name": "Ifnlr1", "organism": "Mouse", "refseq_name": "interferon lambda receptor 1 precursor", "refseq_ac": "NP_777276", "gene_names_uniprotkb": "Ifnlr1; Il28ra", "gene_names_refseq": "CRF2-12; Ifnlr1; Il28ra", "protein_names_uniprotkb": "Interferon lambda receptor 1; CRF2-12; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; IFN-lambda R1; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Interleukin-28 receptor subunit alpha", "protein_names_refseq": "IFN-lambda R1; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; class II cytokine receptor 12; cytokine receptor class-II member 12; cytokine receptor family 2 member 12; interferon lambda receptor 1 precursor; interleukin 28 receptor alpha; interleukin-28 receptor subunit alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:242700); (R-MMU-8854691)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12483210;18250457;21518880", "class_list": "", "function": "The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEV1", "ec_number_list": "", "go_molecular_function": "GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032002 interleukin-28 receptor complex", "go_biological_process": "GO:0050691 regulation of defense response to virus by host;GO:0051607 defense response to virus;GO:0019221 cytokine-mediated signaling pathway;GO:0002385 mucosal immune response;GO:1901857 positive regulation of cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CGK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHT3-1", "uniprot_id": "INT5_MOUSE", "mass": 108348.0, "length": 1018, "protein_name": "Integrator complex subunit 5", "gene_name": "Ints5", "organism": "Mouse", "refseq_name": "integrator complex subunit 5", "refseq_ac": "NP_789813", "gene_names_uniprotkb": "Ints5", "gene_names_refseq": "1110055N21Rik; Ints5; mKIAA1698", "protein_names_uniprotkb": "Integrator complex subunit 5; Int5", "protein_names_refseq": "int5; integrator complex subunit 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:109077); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "31219806;36210013;39627609", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM44", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CHT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2V6-1", "uniprot_id": "IPO11_MOUSE", "mass": 112416.0, "length": 975, "protein_name": "Importin-11", "gene_name": "Ipo11", "organism": "Mouse", "refseq_name": "importin-11 isoform 1", "refseq_ac": "NP_083941", "gene_names_uniprotkb": "Ipo11; Ranbp11", "gene_names_refseq": "1700081H05Rik; 2510001A17Rik; E330021B14Rik; Ipo11; Ranbp11", "protein_names_uniprotkb": "Importin-11; Imp11; Ran-binding protein 11; RanBP11", "protein_names_refseq": "imp11; importin-11 isoform 1; ran-binding protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:76582)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11809816;18299400;20173027;21750661;21952136;25428506;25605945;27802388;30084848;31219806;33300544;34428180;34649567;39627609", "class_list": "", "function": "Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPL12, and of UBE2E3 (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BU45;Q8K0B4", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006610 ribosomal protein import into nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8K2V6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PR8-1", "uniprot_id": "HSPB2_MOUSE", "mass": 20375.0, "length": 182, "protein_name": "Heat shock protein beta-2", "gene_name": "Hspb2", "organism": "Mouse", "refseq_name": "heat shock protein beta-2 isoform 2", "refseq_ac": "NP_001158180", "gene_names_uniprotkb": "Hspb2", "gene_names_refseq": "27kDa; 2810021G24Rik; HSP27; Hspb2; MKBP", "protein_names_uniprotkb": "Heat shock protein beta-2; HspB2", "protein_names_refseq": "heat shock 27kD protein 2; heat shock protein 2; heat shock protein beta-2 isoform 2; heat shock protein beta-2", "tax_id": 10090, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); Charcot-Marie-Tooth disease axonal type 2L (Disease Ontology:DOID:0110174); autosomal dominant distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111206)", "pathway": " (mmu:69253)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12112005;29650953;37295599", "class_list": "", "function": "CD93 Ameliorates Diabetic Wounds by Promoting Angiogenesis via the p38MAPK/MK2/HSP27 Axis., [RefSeq, PubMed]; HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; May regulate the kinase DMPK., [UniProtKB]; Results strongly suggest that glucocorticoid stimulates the induction of neither HSP70 nor HSP90, but HSP27 in osteoblasts, and that p38 MAP kinase is involved in the induction of HSP27, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKE3;Q9CZC2", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007525 somatic muscle development;GO:0043066 negative regulation of apoptotic process;GO:0009408 response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99PR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQU8-1", "uniprot_id": "IMP1L_MOUSE", "mass": 18502.0, "length": 166, "protein_name": "Mitochondrial inner membrane protease subunit 1", "gene_name": "Immp1l", "organism": "Mouse", "refseq_name": "mitochondrial inner membrane protease subunit 1", "refseq_ac": "NP_082536", "gene_names_uniprotkb": "Immp1l", "gene_names_refseq": "1500034J20Rik; 2610528O17Rik; Immp1l", "protein_names_uniprotkb": "Mitochondrial inner membrane protease subunit 1; 3.4.21.-; IMP1-like protein", "protein_names_refseq": "IMP1-like protein; mitochondrial inner membrane protease subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66541)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16450175;34428180", "class_list": "", "function": "Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity)., [UniProtKB]; Murine precursors to cytochrome c1 and glycerol-3-phosphate dehydrogenase are cleaved by murine Imp2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THN4", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0042720 mitochondrial inner membrane peptidase complex;GO:0005739 mitochondrion", "go_biological_process": "GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQZ1-1", "uniprot_id": "HSBP1_MOUSE", "mass": 8611.0, "length": 76, "protein_name": "Heat shock factor-binding protein 1", "gene_name": "Hsbp1", "organism": "Mouse", "refseq_name": "heat shock factor-binding protein 1", "refseq_ac": "NP_077181", "gene_names_uniprotkb": "Hsbp1", "gene_names_refseq": "0610007A03Rik; Hsbp1; Hsp25", "protein_names_uniprotkb": "Heat shock factor-binding protein 1", "protein_names_refseq": "heat shock factor-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68196); (R-MMU-3371568); (R-MMU-3371571)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12592567;14627610;24380799;34428180", "class_list": "", "function": "HSBP1 plays an essential role during early mouse and zebrafish embryonic development; lack of hsbp1 in embryoid bodies leads to disorganization of the germ layers and a reduction in the endoderm-specific markers., [RefSeq, PubMed]; In embryonic mandibles, chondrocytes in the anterior and intermediate portions of Meckel's cartilage showed Hsp25 immunoreactivity from the 12th day of gestation (E12) through E15., [RefSeq, PubMed]; Loss of z-disk and membrane scaffolding proteins immediately after lengthening contractions, and concomitant translocation of HSP25 and alphaB-crystallin to the z-disk, which may help to stabilize or repair cytoskeletal elements at this site., [RefSeq, PubMed]; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKN1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0006936 muscle contraction;GO:0035987 endodermal cell differentiation;GO:0019896 axonal transport of mitochondrion;GO:0070370 cellular heat acclimation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6H2-1", "uniprot_id": "IFT25_MOUSE", "mass": 16281.0, "length": 143, "protein_name": "Intraflagellar transport protein 25 homolog", "gene_name": "Ift25", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 25 homolog", "refseq_ac": "NP_082670", "gene_names_uniprotkb": "Ift25; Hspb11", "gene_names_refseq": "2900042B11Rik; Hspb11; Ift25; PP25", "protein_names_uniprotkb": "Intraflagellar transport protein 25 homolog; Heat shock protein beta-11; Hspb11; PP25; Placental protein 25", "protein_names_refseq": "heat shock protein beta-11; heat shock protein family B (small), member 11; intraflagellar transport protein 25 homolog; placental protein 25 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:72938); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "19253336;22595669;25428506;25605945;28430876;28964737;29626631;30084848;30779550;34428180", "class_list": "", "function": "Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (PubMed:22595669). Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation (PubMed:28430876). Plays a role in the early development of the kidney (PubMed:29626631). May be involved in the regulation of ureteric bud initiation (PubMed:29626631)., [UniProtKB, PubMed, PubMed, PubMed]; FFndings suggest that like IFT25, IFT27, even though not required for ciliogenesis in somatic cells, is essential for sperm flagella formation, sperm function, and male fertility in mice. IFT25 and IFT27 control sperm formation/function through many common mechanisms, but IFT25 has additional roles beyond IFT27., [RefSeq, PubMed]; IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport., [RefSeq, PubMed]; This work indicates that IFT25 and IFT27 are important players in the early development of the kidney and suggest that duplex kidney is part of the ciliopathy spectrum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZR2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0030991 intraciliary transport particle A;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007507 heart development;GO:0015031 protein transport;GO:0030154 cell differentiation;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D6H2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHF7-1", "uniprot_id": "HPGDS_MOUSE", "mass": 23227.0, "length": 199, "protein_name": "Hematopoietic prostaglandin D synthase", "gene_name": "Hpgds", "organism": "Mouse", "refseq_name": "hematopoietic prostaglandin D synthase isoform 1", "refseq_ac": "NP_062328", "gene_names_uniprotkb": "Hpgds; Gsts; Pgds; Ptgds2", "gene_names_refseq": "H-PGDS; Hpgds; Ptgds2", "protein_names_uniprotkb": "Hematopoietic prostaglandin D synthase; 2.5.1.18; 5.3.99.2; GST class-sigma; Glutathione S-transferase; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; H-PGDS; Prostaglandin-H2 D-isomerase", "protein_names_refseq": "GST class-sigma; glutathione S-transferase; glutathione-dependent PGD synthase; glutathione-dependent PGD synthetase; glutathione-requiring prostaglandin D synthase; hematopoietic prostaglandin D synthase isoform 1; prostaglandin D2 synthase 2, hematopoietic; prostaglandin-H2 D-isomerase", "tax_id": 10090, "disease": "allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:54486); (R-MMU-156590); (R-MMU-2162123)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10824118;16547010;20173027;28011936;30084848;30779550;34428180;35922870", "class_list": "", "function": "Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity., [UniProtKB, PubMed, PubMed]; Overexpressing HPGDS in adipose-derived mesenchymal stem cells reduces inflammatory state and improves wound healing in type 2 diabetic mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14AR4;Q8CA80", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;5.3.99.2;1.20.4.2;1.8.5.1;5.3.3.-;5.2.1.2", "go_molecular_function": "GO:0004667 prostaglandin-D synthase activity;GO:0004364 glutathione transferase activity;GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol", "go_biological_process": "GO:2000255 negative regulation of male germ cell proliferation;GO:0006693 prostaglandin metabolic process;GO:0010269 response to selenium ion;GO:0019371 cyclooxygenase pathway;GO:0009624 response to nematode", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JHF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZS6-1", "uniprot_id": "HS3SB_MOUSE", "mass": 43296.0, "length": 390, "protein_name": "Heparan sulfate glucosamine 3-O-sulfotransferase 3B1", "gene_name": "Hs3st3b1", "organism": "Mouse", "refseq_name": "heparan sulfate glucosamine 3-O-sulfotransferase 3B1", "refseq_ac": "NP_061275", "gene_names_uniprotkb": "Hs3st3b1; 3ost3b1; Hs3st3b", "gene_names_refseq": "3-OST-3B; 3OST3B1; 3Ost3b; Hs3st3b1; Hs3st3b; m3-OST-3B", "protein_names_uniprotkb": "Heparan sulfate glucosamine 3-O-sulfotransferase 3B1; 2.8.2.30; 3-OST-3B; Heparan sulfate 3-O-sulfotransferase 3B1; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1; m3-OST-3B", "protein_names_refseq": "D-glycosaminyl 3-O-sulfotransferase-3B; heparan sulfate 3-O-sulfotransferase 3B1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1; heparan sulfate glucosamine 3-O-sulfotransferase 3B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:54710); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10520990", "class_list": "glycogene", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCR0", "ec_number_list": "2.8.2.-;2.8.2.23;2.8.2.29;2.8.2.30", "go_molecular_function": "GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006477 protein sulfation;GO:0006024 glycosaminoglycan biosynthetic process;GO:0001658 branching involved in ureteric bud morphogenesis;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QZS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2G9-1", "uniprot_id": "HTAI2_MOUSE", "mass": 26870.0, "length": 242, "protein_name": "Protein HTATIP2", "gene_name": "Htatip2", "organism": "Mouse", "refseq_name": "protein HTATIP2 isoform b", "refseq_ac": "NP_001139521", "gene_names_uniprotkb": "Htatip2; Cc3; Tip30", "gene_names_refseq": "Cc3; Htatip2; Tip30", "protein_names_uniprotkb": "Protein HTATIP2", "protein_names_refseq": "HIV-1 tat interactive protein 2, 30 kDa homolog; HIV-1 tat interactive protein 2, homolog; oxidoreductase HTATIP2; protein HTATIP2 isoform b; protein HTATIP2; tat-interacting protein 30 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:53415)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14695192;20484733;21952136;25428506;25530119;25605945;30084848;30779550;31219806;31468715;31599954;34428180;38981316;40997131", "class_list": "", "function": "Data suggest that TIP30 plays a negative regulatory role in oligodendroglial differentiation., [RefSeq, PubMed]; Investigating TIP30-Mediated regulation of mTORC1 signaling as a therapeutic strategy for coxsackievirus B3-Induced viral myocarditis., [RefSeq, PubMed]; Represses translation by preventing reactivation of elongation factor eEF1A (PubMed:31468715). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (By similarity). Has additionally been proposed to act as a redox sensor involved in cellular oxidative stress surveillance (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810Y5;Q99KN6;Q9D5F8;Q9D804", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0051287 NAD binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006417 regulation of translation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046777 protein autophosphorylation;GO:0043068 positive regulation of programmed cell death;GO:1901607 alpha-amino acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z2G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CJ70-1", "uniprot_id": "IL19_MOUSE", "mass": 20288.0, "length": 176, "protein_name": "Interleukin-19", "gene_name": "Il19", "organism": "Mouse", "refseq_name": "interleukin-19 isoform 1 precursor", "refseq_ac": "NP_001009940", "gene_names_uniprotkb": "Il19", "gene_names_refseq": "Il19", "protein_names_uniprotkb": "Interleukin-19; IL-19", "protein_names_refseq": "IL-19; interleukin-19 isoform 1 precursor", "tax_id": 10090, "disease": "toxic shock syndrome (Disease Ontology:DOID:14115); asthma (Disease Ontology:DOID:2841); periodontal disease (Disease Ontology:DOID:3388)", "pathway": " (mmu:329244); (R-MMU-5684996); (R-MMU-8854691)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12370360;15557163;19834971;21750661;27053520;33684929;36936941;38502291;38636611;38797538", "class_list": "", "function": "Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:12370360, PubMed:27053520). Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL5 (PubMed:15557163). Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (PubMed:33684929). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid., [RefSeq, PubMed]; Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways., [RefSeq, PubMed]; In a dust mite-induced murine model of asthma, the IL-19 level in asthmatic BALB/cJ mice is twice that of healthy control mice., [RefSeq, PubMed]; Interleukin-19 in Bone Marrow Contributes to Bone Loss Via Suppressing Osteogenic Differentiation Potential of BMSCs in Old Mice., [RefSeq, PubMed]; The colonic interleukin-19 aggravates the dextran sodium sulfate/stress-induced comorbidities due to colitis and anxiety. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043235 receptor complex", "go_biological_process": "GO:0006955 immune response;GO:0006915 apoptotic process;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0010989 negative regulation of low-density lipoprotein particle clearance;GO:0072593 reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CJ70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R366-1", "uniprot_id": "IGSF8_MOUSE", "mass": 65011.0, "length": 611, "protein_name": "Immunoglobulin superfamily member 8", "gene_name": "Igsf8", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily member 8 precursor", "refseq_ac": "NP_536344", "gene_names_uniprotkb": "Igsf8; Ewi2; Kct4; Pgrl", "gene_names_refseq": "ESTM34; EWI-2; Igsf8; KCT-4; PGRL", "protein_names_uniprotkb": "Immunoglobulin superfamily member 8; CD81 partner 3; EWI-2; Glu-Trp-Ile EWI motif-containing protein 2; IgSF8; KCT-4; Keratinocyte-associated transmembrane protein 4; PGRL; Prostaglandin regulatory-like protein", "protein_names_refseq": "CD81 partner 3; PG regulatory-like protein; glu-Trp-Ile EWI motif-containing protein 2; immunoglobulin superfamily member 8 precursor; keratinocyte-associated transmembrane protein 4; prostaglandin regulatory-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:140559)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11673522;12595239;16203089;21609323;21750661;22609062;23575678;25428506;30899004;32152506;33300544;35418614;38657602;40885482", "class_list": "", "function": "IGSF8 is an innate immune checkpoint and cancer immunotherapy target., [RefSeq, PubMed]; Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of beta-catenin degradation., [RefSeq, PubMed]; Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity (PubMed:11673522). Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry. Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion. Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KLRA9 to suppress NK-cell cytotoxicity (PubMed:38657602). May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain (PubMed:16203089)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 23, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0L7", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0030424 axon;GO:0043209 myelin sheath;GO:0045202 synapse;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:2000145 regulation of cell motility;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q8R366-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24547-1", "uniprot_id": "IMDH2_MOUSE", "mass": 55815.0, "length": 514, "protein_name": "Inosine-5'-monophosphate dehydrogenase 2", "gene_name": "Impdh2", "organism": "Mouse", "refseq_name": "inosine-5'-monophosphate dehydrogenase 2 isoform 2", "refseq_ac": "NP_035960", "gene_names_uniprotkb": "Impdh2", "gene_names_refseq": "IMPD 2; IMPDH-II; IMPD; Impdh2", "protein_names_uniprotkb": "Inosine-5'-monophosphate dehydrogenase 2; 1.1.1.205; IMP dehydrogenase 2; IMPD 2; IMPDH 2; IMPDH-II", "protein_names_refseq": "IMP dehydrogenase 2; IMP dehydrogenase type II; inosine 5'-phosphate dehydrogenase 2; inosine-5'-monophosphate dehydrogenase 2 isoform 2; inosine-5'-monophosphate dehydrogenase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:23918); (R-MMU-6798695); (R-MMU-73817); (R-MMU-9748787)", "pathway_count": 4, "publication_count": 29, "publication_id_list": "1671845;18299400;19224205;20173027;20484733;21183079;21540332;21750661;21952136;22645316;24788674;25428506;2572589;28135057;28528544;30084848;30779550;32152506;34428180;34887587;35820727;35984892;36210013;37828378;38009721;38692012;38717553;38959733;7906545", "class_list": "", "function": "Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Deletion of Impdh2 in adipocyte precursors limits the expansion of white adipose tissue and enhances metabolic health with overnutrition., [RefSeq, PubMed]; IMPDH2 forms spots at branching sites and distal ends of astrocyte stem processes., [RefSeq, PubMed]; Impdh2 deficiency suppresses osteoclastogenesis through mitochondrial oxidative phosphorylation and alleviates ovariectomy-induced osteoporosis., [RefSeq, PubMed]; The IMPDH cytoophidium couples metabolism and fetal development in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61734;Q91Z11", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;2.7.10.2;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.11.39;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;2.7.1.35;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007623 circadian rhythm;GO:0071353 cellular response to interleukin-4;GO:0046651 lymphocyte proliferation;GO:0006177 GMP biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P24547-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ29-1", "uniprot_id": "IGB1B_MOUSE", "mass": 39246.0, "length": 343, "protein_name": "Immunoglobulin-binding protein 1b", "gene_name": "Igbp1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Igbp1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin-binding protein 1b; Alpha 4-b protein; CD79a-binding protein 1b; Protein alpha-4-b", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:50540)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10491115;21750661", "class_list": "", "function": "Associated to surface IgM-receptor; may be involved in signal transduction (By similarity). May be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051721 protein phosphatase 2A binding;GO:0019208 phosphatase regulator activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0035303 regulation of dephosphorylation;GO:0007165 signal transduction;GO:0042113 B cell activation;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZ29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXH4-1", "uniprot_id": "ITAX_MOUSE", "mass": 129151.0, "length": 1169, "protein_name": "Integrin alpha-X", "gene_name": "Itgax", "organism": "Mouse", "refseq_name": "integrin alpha-X isoform 1 precursor", "refseq_ac": "NP_067309", "gene_names_uniprotkb": "Itgax", "gene_names_refseq": "Cd11c; Cr4; Itgax; N418", "protein_names_uniprotkb": "Integrin alpha-X; CD11 antigen-like family member C; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95", "protein_names_refseq": "CD11 antigen-like family member C; CD11C (p150) alpha polypeptide; complement receptor 4; integrin aX; integrin alpha-X isoform 1 precursor; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95", "tax_id": 10090, "disease": "", "pathway": " (mmu:16411); (R-MMU-202733); (R-MMU-216083); (R-MMU-3000178); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;20173027;21750661;21913724;26495903;26740625;28935714;34428180", "class_list": "", "function": "Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030971 receptor tyrosine kinase binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0034689 integrin alphaX-beta2 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QXH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8HW98-1", "uniprot_id": "IGLO5_MOUSE", "mass": 36767.0, "length": 336, "protein_name": "IgLON family member 5", "gene_name": "Iglon5", "organism": "Mouse", "refseq_name": "igLON family member 5 precursor", "refseq_ac": "NP_001157990", "gene_names_uniprotkb": "Iglon5", "gene_names_refseq": "A230106M20Rik; Gm1431; Iglon5", "protein_names_uniprotkb": "IgLON family member 5", "protein_names_refseq": "igLON family member 5 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:210094)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;38370417;38657185", "class_list": "", "function": "IgLON5 deficiency produces behavioral alterations in a knockout mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; Phenotypic Insights Into Anti-IgLON5 Disease in IgLON5-Deficient Mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A7E1X9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0050885 neuromuscular process controlling balance;GO:0051963 regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0061744 motor behavior", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8HW98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UL9-1", "uniprot_id": "JAML_MOUSE", "mass": 42533.0, "length": 379, "protein_name": "Junctional adhesion molecule-like", "gene_name": "Jaml", "organism": "Mouse", "refseq_name": "junctional adhesion molecule-like precursor", "refseq_ac": "NP_001005421", "gene_names_uniprotkb": "Jaml; Amica1; Gm638", "gene_names_refseq": "AMICA; Amica1; Crea7; Gm638; Jaml", "protein_names_uniprotkb": "Junctional adhesion molecule-like; Dendritic cell-specific protein CREA7; mCrea7", "protein_names_refseq": "adhesion molecule AMICA; adhesion molecule, interacts with CXADR antigen 1; dendritic cell-specific protein CREA7; dendritic-cell specific protein Crea7; junctional adhesion molecule-like precursor; mCrea7", "tax_id": 10090, "disease": "", "pathway": " (mmu:270152); (R-MMU-198933); (R-MMU-202733)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "18250455;20813954;20813955;21220118;21750661;26740625;30084848;33186558;34427588;34428180;35708906;37619972;38625487", "class_list": "", "function": "Crystal structure of junctional adhesion molecule-like protein (JAML) and coxsackie and adenovirus receptor; data show how CAR-mediated clustering of JAML recruits phosphoinositide 3-kinase to a JAML intracellular sequence motif, [RefSeq, PubMed]; Crystal structure of the JAML-HL4E10 Fab complex, [RefSeq, PubMed]; Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism., [RefSeq, PubMed]; Identified an epithelial gammadelta T cell costimulatory molecule, junctional adhesion molecule-like protein - JAML; binding of JAML to CAR provides costimulation leading to cell proliferation and cytokine and growth factor production, [RefSeq, PubMed]; JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment., [RefSeq, PubMed]; JAML promotes CD8 and gammadelta T cell antitumor immunity and is a novel target for cancer immunotherapy., [RefSeq, PubMed]; JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity., [RefSeq, PubMed]; Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 1, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QNV7;Q5DTC4", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0042803 protein homodimerization activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane", "go_biological_process": "GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0046629 gamma-delta T cell activation;GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing;GO:0030593 neutrophil chemotaxis;GO:0072672 neutrophil extravasation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q80UL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97875-1", "uniprot_id": "JDP2_MOUSE", "mass": 18675.0, "length": 163, "protein_name": "Jun dimerization protein 2", "gene_name": "Jdp2", "organism": "Mouse", "refseq_name": "jun dimerization protein 2", "refseq_ac": "NP_001191981", "gene_names_uniprotkb": "Jdp2; Jundm2", "gene_names_refseq": "Jdp2; Jundm2; Jundp2; TIF", "protein_names_uniprotkb": "Jun dimerization protein 2", "protein_names_refseq": "c-Jun dimerization protein 2; jun dimerization protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:81703)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11231009;11602244;12052888;12171923;12225289;12707301;14627710;18307971;21750661;28146118;29769710;30217453;30670778;30818334;33265909", "class_list": "", "function": "Characterization of binding sites for stress mitogen-activated protein kinases on JDP2, [RefSeq, PubMed]; Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin (By similarity)., [UniProtKB, PubMed, PubMed]; JDP2 overexpression is associated with heart failure development. Publication Status: Online-Only, [RefSeq, PubMed]; JDP2 protein plays a major role in promoting skeletal muscle differentiation via its involvement in cell cycle arrest and activation of the myogenic program, [RefSeq, PubMed]; JDP2 regulates the expression of essential tumor promoting factors, such as Sdf1 expressed by cancer associated fibroblasts within the tumor microenvironment, and thus restrain tumor growth., [RefSeq, PubMed]; JDP2 role in the traumatic brain injury and cognitive function.JDP2 promoted caspase-3 activation in astrocytes., [RefSeq, PubMed]; JDP2, repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.JDP2 is key factor that controls the commitment of F9 cells to differentiation and shed light on AP-1 repressor functions, [RefSeq, PubMed]; Results suggest that Jun dimerization protein 2 (JDP2) may play an important role in the RANK-mediated signal transduction system, especially in osteoclast differentiation., [RefSeq, PubMed]; Structural, Pro-Inflammatory and Calcium Handling Remodeling Underlies Spontaneous Onset of Paroxysmal Atrial Fibrillation in JDP2-Overexpressing Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Transgenic mice with cardiac expression of either JDP2 or ATF3 showed maladaptive remodeling and cardiac dysfunction. Surprisingly, JDP2 knockout (KO) did not protect the heart following transverse aortic constriction. Instead, the JDP2 KO mice performed worse than their wild type counterparts. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045599 negative regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P97875-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62469-1", "uniprot_id": "ITA2_MOUSE", "mass": 128955.0, "length": 1178, "protein_name": "Integrin alpha-2", "gene_name": "Itga2", "organism": "Mouse", "refseq_name": "integrin alpha-2 precursor", "refseq_ac": "NP_032422", "gene_names_uniprotkb": "Itga2", "gene_names_refseq": "CD49B; DX5; GPIa; Itga2", "protein_names_uniprotkb": "Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; GPIa; Platelet membrane glycoprotein Ia; VLA-2 subunit alpha", "protein_names_refseq": "CD49 antigen-like family member B; VLA-2 receptor, alpha 2 subunit; collagen receptor; integrin alpha-2 precursor; platelet membrane glycoprotein Ia", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); von Willebrand's disease 1 (Disease Ontology:DOID:0060573); von Willebrand's disease 2 (Disease Ontology:DOID:0060574); thrombosis (Disease Ontology:DOID:0060903); sensorineural hearing loss (Disease Ontology:DOID:10003); iron deficiency anemia (Disease Ontology:DOID:11758); Behcet's disease (Disease Ontology:DOID:13241); thrombocytopenia (Disease Ontology:DOID:1588); retinal vein occlusion (Disease Ontology:DOID:1727); Glanzmann's thrombasthenia (Disease Ontology:DOID:2219); arteriosclerosis (Disease Ontology:DOID:2349); placental insufficiency (Disease Ontology:DOID:3891); myocardial infarction (Disease Ontology:DOID:5844); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:16398); (R-MMU-216083); (R-MMU-3000170); (R-MMU-3000178); (R-MMU-8874081)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16754960;21750661;25428506;30084848;30899004;34428180;35182768;35820727;7521231;8081889", "class_list": "", "function": "Characterization of Glycoproteoforms of Integrins alpha2 and beta1 in Megakaryocytes in the Occurrence of JAK2V617F Mutation-Induced Primary Myelofibrosis., [RefSeq, PubMed]; Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 17, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q62163;Q6P1C7", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0046872 metal ion binding;GO:0001540 amyloid-beta binding;GO:0005518 collagen binding;GO:0043236 laminin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0030424 axon;GO:0043679 axon terminus", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0045785 positive regulation of cell adhesion;GO:0045987 positive regulation of smooth muscle contraction;GO:0001666 response to hypoxia;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q62469-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1A546-1", "uniprot_id": "ISX_MOUSE", "mass": 27169.0, "length": 240, "protein_name": "Intestine-specific homeobox", "gene_name": "Isx", "organism": "Mouse", "refseq_name": "intestine-specific homeobox isoform 1", "refseq_ac": "NP_001281207", "gene_names_uniprotkb": "Isx", "gene_names_refseq": "9130012O13Rik; Isx; Pix-1", "protein_names_uniprotkb": "Intestine-specific homeobox", "protein_names_refseq": "intestine-specific homeobox isoform 1; pancreas-intestine homeodomain transcription factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:71597)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16971476;18093975", "class_list": "", "function": "Isx participates in the maintenance of vitamin A metabolism by regulating Bcmo1 expression in the intestine., [RefSeq, PubMed]; Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A545;Q9D2Z0", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048666 neuron development;GO:1904479 negative regulation of intestinal absorption;GO:1901738 regulation of vitamin A metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A1A546-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A863-1", "uniprot_id": "ITB4_MOUSE", "mass": 201650.0, "length": 1818, "protein_name": "Integrin beta-4", "gene_name": "Itgb4", "organism": "Mouse", "refseq_name": "integrin beta-4 isoform 4 precursor", "refseq_ac": "NP_001392055", "gene_names_uniprotkb": "Itgb4", "gene_names_refseq": "C230078O20; CD104; Itgb4", "protein_names_uniprotkb": "Integrin beta-4", "protein_names_refseq": "Integrin beta-4; integrin beta-4 isoform 4 precursor", "tax_id": 10090, "disease": "junctional epidermolysis bullosa with pyloric atresia (Disease Ontology:DOID:0060733); junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); junctional epidermolysis bullosa (Disease Ontology:DOID:3209)", "pathway": " (mmu:192897); (R-MMU-3000170); (R-MMU-446107)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;31219806;34418053;34428180;37698050;8359687", "class_list": "", "function": "Conditional knockout of ITGB4 in bronchial epithelial cells directs bronchopulmonary dysplasia., [RefSeq, PubMed]; Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2A865;A2A866;Q6PCS0;Q8R3J1;Q91W15", "ec_number_list": "", "go_molecular_function": "GO:0038132 neuregulin binding;GO:0005178 integrin binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031994 insulin-like growth factor I binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0005938 cell cortex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0046847 filopodium assembly;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A2A863-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ARA8-1", "uniprot_id": "ITA8_MOUSE", "mass": 117556.0, "length": 1062, "protein_name": "Integrin alpha-8", "gene_name": "Itga8", "organism": "Mouse", "refseq_name": "integrin alpha-8 isoform 1 preproprotein", "refseq_ac": "NP_001001309", "gene_names_uniprotkb": "Itga8", "gene_names_refseq": "Itga8", "protein_names_uniprotkb": "Integrin alpha-8", "protein_names_refseq": "integrin alpha-8 isoform 1 preproprotein", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059); renal agenesis (Disease Ontology:DOID:14766); ovarian cancer (Disease Ontology:DOID:2394); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); schizophrenia (Disease Ontology:DOID:5419); end stage renal disease (Disease Ontology:DOID:783); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:241226); (R-MMU-2129379); (R-MMU-216083); (R-MMU-2173789); (R-MMU-3000178)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10024342;10504498;10742111;11470831;11891185;12787402;14500699;17537792;21750661;26740625;31219806;34428180;9054500;9548928;9614184", "class_list": "", "function": "Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 5, "disease_count": 7, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "O70304;Q3UXV8;Q8BRG3;Q8C0H7", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0007399 nervous system development;GO:0007613 memory;GO:0030198 extracellular matrix organization;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "A2ARA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2V2-1", "uniprot_id": "IFFO2_MOUSE", "mass": 56994.0, "length": 512, "protein_name": "Intermediate filament family orphan 2", "gene_name": "Iffo2", "organism": "Mouse", "refseq_name": "intermediate filament family orphan 2 isoform 1", "refseq_ac": "NP_001192102", "gene_names_uniprotkb": "Iffo2", "gene_names_refseq": "Iffo2", "protein_names_uniprotkb": "Intermediate filament family orphan 2", "protein_names_refseq": "intermediate filament family orphan 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:212632)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RRL2-1", "uniprot_id": "JERKL_MOUSE", "mass": 59710.0, "length": 523, "protein_name": "Jerky protein homolog-like", "gene_name": "Jrkl", "organism": "Mouse", "refseq_name": "jerky protein homolog-like", "refseq_ac": "NP_001028353", "gene_names_uniprotkb": "Jrkl", "gene_names_refseq": "C030035D04Rik; HHMJG; Jrkl", "protein_names_uniprotkb": "Jerky protein homolog-like", "protein_names_refseq": "jerky homolog-like; jerky protein homolog-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:77532)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2Y6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RRL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0LLJ0-1", "uniprot_id": "IMA8_MOUSE", "mass": 55458.0, "length": 499, "protein_name": "Importin subunit alpha-8", "gene_name": "Kpna7", "organism": "Mouse", "refseq_name": "importin subunit alpha-8 isoform 2", "refseq_ac": "NP_001013796", "gene_names_uniprotkb": "Kpna7", "gene_names_refseq": "Gm1055; Kpna7", "protein_names_uniprotkb": "Importin subunit alpha-8; Karyopherin subunit alpha-7", "protein_names_refseq": "importin alpha 2; importin subunit alpha-8 isoform 2; importin subunit alpha-8; karyopherin alpha 7 (importin alpha 8); nuclear transport receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:381686)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20699224;20701745;21750661;28189564;31219806", "class_list": "", "function": "A decreased H7N9 influenza A virus polymerase activity when importin-alpha7 was silenced by siRNA, is reported., [RefSeq, PubMed]; A novel importin alpha family member with distinct subcellular localization and nuclear localization signal binding characteristics Publication Status: Online-Only, [RefSeq, PubMed]; Functions in nuclear protein import., [UniProtKB, UniProtKB]; Knocking out of Kpna7 induced abnormalities of gene expression (dppa2, dppa4, and piwil2) and epigenetic modifications (down-regulation of histone H3K27me3). Biochemical analysis showed that KPNA7 interacts with KPNB1 (importin-beta1)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C0LLJ1;Q3UWY3;Q58HC5", "ec_number_list": "", "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0042564 NLS-dependent protein nuclear import complex", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0040029 epigenetic regulation of gene expression;GO:0001824 blastocyst development;GO:0006607 NLS-bearing protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "C0LLJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64112-1", "uniprot_id": "IFIT2_MOUSE", "mass": 55021.0, "length": 472, "protein_name": "Interferon-induced protein with tetratricopeptide repeats 2", "gene_name": "Ifit2", "organism": "Mouse", "refseq_name": "interferon-induced protein with tetratricopeptide repeats 2", "refseq_ac": "NP_032358", "gene_names_uniprotkb": "Ifit2; Garg39; Ifi54; Isg54", "gene_names_refseq": "GARG-39; IFI-54K; Ifi54; Ifit2; P54", "protein_names_uniprotkb": "Interferon-induced protein with tetratricopeptide repeats 2; GARG-39; Glucocorticoid-attenuated response gene 39 protein; IFI-54K; IFIT-2; Interferon-induced 54 kDa protein; P54", "protein_names_refseq": "IFIT-2; glucocorticoid-attenuated response gene 39 protein; interferon-induced 54 kDa protein; interferon-induced protein with tetratricopeptide repeats 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:15958)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16023166;17030862;20950130;21085181;21750661;22615570;38888342;39276454;7896268;8660659", "class_list": "", "function": "IFIT2 mediates iron retention and cholesterol efflux in atherosclerosis., [RefSeq, PubMed]; IFIT2/GARG39 was identified as a microtubule-associated protein enriched in the mitotic spindle of mouse NIH3T3 and B16F10 melanoma cells., [RefSeq, PubMed]; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis., [UniProtKB, PubMed, PubMed]; The interferon-induced protein, IFIT2, requires RNA-binding activity and neuronal expression to protect mice from intranasal vesicular stomatitis virus infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62385", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0009615 response to virus;GO:0071345 cellular response to cytokine stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26011-1", "uniprot_id": "ITB7_MOUSE", "mass": 87411.0, "length": 806, "protein_name": "Integrin beta-7", "gene_name": "Itgb7", "organism": "Mouse", "refseq_name": "integrin beta-7 precursor", "refseq_ac": "NP_038594", "gene_names_uniprotkb": "Itgb7", "gene_names_refseq": "Itgb7; Ly69", "protein_names_uniprotkb": "Integrin beta-7; Integrin beta-P; M290 IEL antigen", "protein_names_refseq": "M290 IEL antigen; integrin beta-7 precursor; integrin beta-P", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:16421); (R-MMU-198933); (R-MMU-216083)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "12682249;1381390;1518854;1559978;1710115;21750661;26495903;26740625;28011936;31219806;34428180;35984892;36210013;38806623;38997751;8318458", "class_list": "", "function": "Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Also interacts with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin., [UniProtKB, UniProtKB]; The integrin receptor beta7 subunit mediates airway remodeling and hyperresponsiveness in allergen exposed mice. Publication Status: Online-Only, [RefSeq, PubMed]; The protective roles of integrin alpha4beta7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2M1;Q64656", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0046872 metal ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0008305 integrin complex;GO:0034669 integrin alpha4-beta7 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion;GO:0033627 cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion;GO:0034446 substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P26011-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHA0-1", "uniprot_id": "IN80C_MOUSE", "mass": 20405.0, "length": 191, "protein_name": "INO80 complex subunit C", "gene_name": "Ino80c", "organism": "Mouse", "refseq_name": "INO80 complex subunit C", "refseq_ac": "NP_766213", "gene_names_uniprotkb": "Ino80c", "gene_names_refseq": "D030070L09Rik; Ino80c", "protein_names_uniprotkb": "INO80 complex subunit C", "protein_names_refseq": "INO80 complex subunit C", "tax_id": 10090, "disease": "", "pathway": " (mmu:225280); (R-MMU-5689603); (R-MMU-5696394)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031011 Ino80 complex;GO:0001650 fibrillar center;GO:0071339 MLL1 complex", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BHA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01326-1", "uniprot_id": "INS2_MOUSE", "mass": 12364.0, "length": 110, "protein_name": "Insulin-2", "gene_name": "Ins2", "organism": "Mouse", "refseq_name": "insulin-2 preproprotein", "refseq_ac": "NP_001172012", "gene_names_uniprotkb": "Ins2; Ins-2", "gene_names_refseq": "Ins-2; Ins2; InsII; Mody4; Mody", "protein_names_uniprotkb": "Insulin-2", "protein_names_refseq": "insulin-2 preproprotein; insulin-2; proinsulin", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); type 1 diabetes mellitus 2 (Disease Ontology:DOID:0110741); maturity-onset diabetes of the young type 10 (Disease Ontology:DOID:0111108); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); neonatal diabetes mellitus (Disease Ontology:DOID:11717); pancreatic cancer (Disease Ontology:DOID:1793); hyperuricemia (Disease Ontology:DOID:1920); hyperinsulinism (Disease Ontology:DOID:2018); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); insulinoma (Disease Ontology:DOID:3892); cholangiocarcinoma (Disease Ontology:DOID:4947); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:16334); (R-MMU-264876); (R-MMU-422085); (R-MMU-6807878); (R-MMU-6811558); (R-MMU-74713); (R-MMU-74749); (R-MMU-74751); (R-MMU-74752); (R-MMU-77387)", "pathway_count": 10, "publication_count": 50, "publication_id_list": "10470079;10756085;11375327;11465945;11673498;12193712;12727928;14599847;15120754;16804066;17437424;17459508;17615584;17675466;18626021;19286348;20153322;20190756;20503259;20534455;21690251;21750661;21949373;22043012;22065673;22315318;22539795;22647732;23894591;2397023;23977133;24127484;24550292;24943217;25063871;27406624;27802879;28344989;28835461;29712852;30022165;3104603;31471352;32152506;32928873;33151102;34203471;36032090;5063718;7537670", "class_list": "", "function": "Alternative splicing of insulin mRNA in mice could result in an additional level of regulation in insulin biosynthesis., [RefSeq, PubMed]; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005158 insulin receptor binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0005159 insulin-like growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0050709 negative regulation of protein secretion;GO:1904659 D-glucose transmembrane transport;GO:0045818 negative regulation of glycogen catabolic process;GO:0045922 negative regulation of fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "P01326-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61703-1", "uniprot_id": "ITIH2_MOUSE", "mass": 105928.0, "length": 946, "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H2", "gene_name": "Itih2", "organism": "Mouse", "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H2 precursor", "refseq_ac": "NP_034712", "gene_names_uniprotkb": "Itih2", "gene_names_refseq": "ITI-HC2; Intin2; Itih-2; Itih2", "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H2; ITI heavy chain H2; ITI-HC2; Inter-alpha-inhibitor heavy chain 2", "protein_names_refseq": "ITI heavy chain H2; inter-alpha-inhibitor heavy chain 2; inter-alpha-trypsin inhibitor heavy chain H2 precursor; inter-alpha-trypsin inhibitor heavy chain H2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16425); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;15345747;16479539;16944957;17242355;17330941;21183079;21750661;22872234;25428506;26495903;28011936;30084848;34203471;34428180;35984892;36210013;37507081;37828378;39627609;7534067", "class_list": "", "function": "May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2AKU6;Q3UZM0", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030212 hyaluronan metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q61703-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ES17-1", "uniprot_id": "IL21_MOUSE", "mass": 16811.0, "length": 146, "protein_name": "Interleukin-21", "gene_name": "Il21", "organism": "Mouse", "refseq_name": "interleukin-21 isoform 2 precursor", "refseq_ac": "NP_068554", "gene_names_uniprotkb": "Il21", "gene_names_refseq": "IL-21; Il21", "protein_names_uniprotkb": "Interleukin-21; IL-21", "protein_names_refseq": "interleukin-21 isoform 2 precursor", "tax_id": 10090, "disease": "common variable immunodeficiency 11 (Disease Ontology:DOID:0081153); celiac disease (Disease Ontology:DOID:10608); anogenital venereal wart (Disease Ontology:DOID:11168); allergic disease (Disease Ontology:DOID:1205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); autoimmune hepatitis (Disease Ontology:DOID:2048); asthma (Disease Ontology:DOID:2841); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); periodontal disease (Disease Ontology:DOID:3388); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); hepatocellular carcinoma (Disease Ontology:DOID:684); neuromyelitis optica (Disease Ontology:DOID:8869); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:60505); (R-MMU-9020958)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11081504;11970879;12370258;12393685;12446913;12893770;15100251;21750661;23045607", "class_list": "", "function": "A T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells, [RefSeq, PubMed]; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (PubMed:15100251). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (PubMed:23045607). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15 (PubMed:11970879). May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (PubMed:12893770)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Has a significant influence on the regulation of B cell function in vivo and cooperates with IL-4, [RefSeq, PubMed]; IL-21 down-regulates IgE production from IL-4-stimulated B cells through the inhibition of germ line C(epsilon) transcription and thus suggest that IL-21 may be useful for the treatment of IgE-dependent allergic diseases., [RefSeq, PubMed]; IL-21 promotes the transition between innate and adaptive immunity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005134 interleukin-2 receptor binding;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0032740 positive regulation of interleukin-17 production;GO:0006952 defense response;GO:0008284 positive regulation of cell population proliferation;GO:0001819 positive regulation of cytokine production;GO:0002314 germinal center B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9ES17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C872-1", "uniprot_id": "JMJD7_MOUSE", "mass": 35917.0, "length": 316, "protein_name": "Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7", "gene_name": "Jmjd7", "organism": "Mouse", "refseq_name": "bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7", "refseq_ac": "NP_001108109", "gene_names_uniprotkb": "Jmjd7", "gene_names_refseq": "Jmjd7", "protein_names_uniprotkb": "Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7; 1.14.11.63; 3.4.-.-; JmjC domain-containing protein 7; Jumonji domain-containing protein 7; L-lysine (3S)-hydroxylase Jmjd7", "protein_names_refseq": "L-lysine (3S)-hydroxylase Jmjd7; bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7; jmjC domain-containing protein 7; jumonji domain-containing protein 7", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:433466); (R-MMU-9629569)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;28847961;29459673", "class_list": "", "function": "Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (By similarity) (PubMed:28847961). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery. Acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (By similarity)., [UniProtKB, UniProtKB, PubMed]; Recognition between JMJD5/JMJD7 and histone substrates is specific, which is reflected by the binding data between enzymes and substrates. High structural similarity between JMJD5 and JMJD7 is reflected by the shared common substrates and high binding affinity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AP62;Q4QQM1;Q80VV8;Q91W88", "ec_number_list": "3.4.-.-;1.14.11.63;3.6.5.-", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0018126 protein hydroxylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C872-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56477-1", "uniprot_id": "IRF5_MOUSE", "mass": 56005.0, "length": 497, "protein_name": "Interferon regulatory factor 5", "gene_name": "Irf5", "organism": "Mouse", "refseq_name": "interferon regulatory factor 5 isoform 1", "refseq_ac": "NP_001239311", "gene_names_uniprotkb": "Irf5", "gene_names_refseq": "Irf5; mirf5", "protein_names_uniprotkb": "Interferon regulatory factor 5; IRF-5", "protein_names_refseq": "interferon regulatory factor 5 bone marrow; interferon regulatory factor 5 isoform 1", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); inflammatory bowel disease 14 (Disease Ontology:DOID:0110895); obstructive jaundice (Disease Ontology:DOID:13603); hepatitis C (Disease Ontology:DOID:1883); multiple sclerosis (Disease Ontology:DOID:2377); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); pneumonia (Disease Ontology:DOID:552); rheumatoid arthritis (Disease Ontology:DOID:7148); herpes simplex (Disease Ontology:DOID:8566); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:27056); (R-MMU-9860276)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15665823;17275788;17360658;18824541;21750661;25326420;26740625;32494619;38271298;38367238", "class_list": "", "function": "IRF5 is critical for antiviral immunity and for the induction of apoptosis, but not cell cycle arrest in response to DNA damage, and acts as a tumor suppressor on a pathway that may be distinct from that for p53., [RefSeq, PubMed]; Interferon Regulatory Factor 5 Regulates the Phagocytosis of Microglia and Alleviate Alzheimer's Pathology., [RefSeq, PubMed]; Study identifies IRF-5 as a new, principal downstream regulator of the TLR-MyD88 signalling pathway and a potential target of therapeutic intervention to control harmful immune responses, [RefSeq, PubMed]; The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection., [RefSeq, PubMed]; Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:15665823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15665823). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (PubMed:15665823)., [UniProtKB, PubMed]; We also provide evidence that this TLR synergy is mediated, at least in part, by activation of the transcription factor interferon regulatory factor 5 (IRF5)., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0032727 positive regulation of interferon-alpha production;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P56477-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZV7-1", "uniprot_id": "INT13_MOUSE", "mass": 82780.0, "length": 732, "protein_name": "Integrator complex subunit 13", "gene_name": "IntS13; Ints13", "organism": "Mouse", "refseq_name": "integrator complex subunit 13 isoform 2", "refseq_ac": "NP_620096", "gene_names_uniprotkb": "IntS13; Ints13; Asun; Spata30", "gene_names_refseq": "4933424B01Rik; Asun; Ints13; Spata30", "protein_names_uniprotkb": "Integrator complex subunit 13; Cell cycle regulator Mat89Bb homolog; Protein asunder homolog; Spermatogenesis-associated protein 30", "protein_names_refseq": "asunder, spermatogenesis regulator; cell cycle regulator Mat89Bb homolog; integrator complex subunit 13 isoform 2; likely orthologue of H. sapiens chromosome 12 open reading frame 11 (C12orf11); protein asunder homolog; spermatogenesis associated 30; spermatogenesis-associated protein 30", "tax_id": 10090, "disease": "", "pathway": " (mmu:71177); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;23097494;23904267;25428506;31219806;34428180", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS13 is part of the integrator tail module and acts as a platform for the recruitment of transcription factors at promoters. At prophase, mediates recruitment of cytoplasmic dynein to the nuclear envelope, a step important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLV7;Q99JT8", "ec_number_list": "", "go_molecular_function": "GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0051301 cell division;GO:0030317 flagellated sperm motility;GO:0007346 regulation of mitotic cell cycle;GO:0016180 snRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8QZV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4B4-1", "uniprot_id": "IL23R_MOUSE", "mass": 73453.0, "length": 644, "protein_name": "Interleukin-23 receptor", "gene_name": "Il23r", "organism": "Mouse", "refseq_name": "interleukin-23 receptor precursor", "refseq_ac": "NP_653131", "gene_names_uniprotkb": "Il23r", "gene_names_refseq": "IL-23R; Il23r", "protein_names_uniprotkb": "Interleukin-23 receptor; IL-23 receptor; IL-23R", "protein_names_refseq": "IL-23 receptor; interleukin-23 receptor precursor", "tax_id": 10090, "disease": "Graves ophthalmopathy (Disease Ontology:DOID:0081120); inflammatory bowel disease 17 (Disease Ontology:DOID:0110883); psoriasis 7 (Disease Ontology:DOID:0111279); osteonecrosis (Disease Ontology:DOID:10159); celiac disease (Disease Ontology:DOID:10608); sarcoidosis (Disease Ontology:DOID:11335); Graves' disease (Disease Ontology:DOID:12361); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary tuberculosis (Disease Ontology:DOID:2957); systemic scleroderma (Disease Ontology:DOID:418); rhinitis (Disease Ontology:DOID:4483); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); arthritis (Disease Ontology:DOID:848); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:209590); (R-MMU-9020933)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12023369;21750661;30059200", "class_list": "", "function": "Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 22, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005143 interleukin-12 receptor binding;GO:0017046 peptide hormone binding;GO:0019955 cytokine binding;GO:0004925 prolactin receptor activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0072536 interleukin-23 receptor complex", "go_biological_process": "GO:0032693 negative regulation of interleukin-10 production;GO:0006954 inflammatory response;GO:0008284 positive regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0002230 positive regulation of defense response to virus by host", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K4B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35368-1", "uniprot_id": "IFI3_MOUSE", "mass": 46300.0, "length": 408, "protein_name": "Interferon-activable protein 203", "gene_name": "Ifi203", "organism": "Mouse", "refseq_name": "interferon-activable protein 203 isoform 1", "refseq_ac": "NP_001289578", "gene_names_uniprotkb": "Ifi203", "gene_names_refseq": "Ifi203a; Ifi203b; Ifi203; Mndal", "protein_names_uniprotkb": "Interferon-activable protein 203; Ifi-203; Interferon-inducible protein p203", "protein_names_refseq": "interferon-activable protein 203 isoform 1; interferon-activable protein 203; interferon-inducible protein p203", "tax_id": 10090, "disease": "", "pathway": " (mmu:15950)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17981725;21750661;25428506;30084848;31219806;31599954;33417276;34428180;40997131;9363777", "class_list": "", "function": "Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9I1;Q3TEA2;Q3TP57;Q3UMV2;Q8BYE5;Q91VV8", "ec_number_list": "", "go_molecular_function": "GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005634 nucleus", "go_biological_process": "GO:0002218 activation of innate immune response;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35679-1", "uniprot_id": "ISK4_MOUSE", "mass": 9729.0, "length": 86, "protein_name": "Serine protease inhibitor Kazal-type 4", "gene_name": "Spink4", "organism": "Mouse", "refseq_name": "serine protease inhibitor Kazal-type 4 precursor", "refseq_ac": "NP_035593", "gene_names_uniprotkb": "Spink4; Mpgc60", "gene_names_refseq": "MPGC60; Spink4", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 4; MPGC60 protein; Peptide PEC-60 homolog", "protein_names_refseq": "peptide PEC-60 homolog; serine protease inhibitor Kazal-type 4 precursor; serine protease inhibitor Kazal-type 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:20731)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "37013514;9810707", "class_list": "", "function": "SPINK4 promotes colorectal cancer cell proliferation and inhibits ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149Z4", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35679-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88995-1", "uniprot_id": "IKBL1_MOUSE", "mass": 43202.0, "length": 381, "protein_name": "NF-kappa-B inhibitor-like protein 1", "gene_name": "Nfkbil1", "organism": "Mouse", "refseq_name": "NF-kappa-B inhibitor-like protein 1 isoform 1", "refseq_ac": "NP_035039", "gene_names_uniprotkb": "Nfkbil1; Ikbl", "gene_names_refseq": "Def-7; IKBL; Nfkbil1; ikappaBL", "protein_names_uniprotkb": "NF-kappa-B inhibitor-like protein 1; I-kappa-B-like protein; IkappaBL; Inhibitor of kappa B-like protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1", "protein_names_refseq": "I-kappa-B-like protein; NF-kappa-B inhibitor-like protein 1 isoform 1; NF-kappa-B inhibitor-like protein 1; inhibitor of kappa B-like protein", "tax_id": 10090, "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:18038)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10023090;14656967;21284685", "class_list": "", "function": "Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (By similarity)., [UniProtKB]; NFKBIL-1 affects the pathogenesis of rheumatoid arthritis at least in part by the regulation of dendritic cell functions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91X16;Q9R1Y3", "ec_number_list": "", "go_molecular_function": "GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0032720 negative regulation of tumor necrosis factor production;GO:0071222 cellular response to lipopolysaccharide;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0034122 negative regulation of toll-like receptor signaling pathway;GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88995-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01837-1", "uniprot_id": "IGKC_MOUSE", "mass": 11934.0, "length": 107, "protein_name": "Immunoglobulin kappa constant", "gene_name": "Igkc", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Igkc", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa constant; Ig kappa chain C region MOPC 21", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 18, "publication_id_list": "103625;21750661;29187734;3138116;33725478;34428180;34887587;35820727;35984892;36064721;36288343;37453647;4638343;5073237;6170937;6262318;6775818;6785724", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A075B5P2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0042105 alpha-beta T cell receptor complex;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P01837-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03987-1", "uniprot_id": "IGHG3_MOUSE", "mass": 43929.0, "length": 398, "protein_name": "Ig gamma-3 chain C region", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig gamma-3 chain C region", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17330941;25605945;36583994;40997131;6092053;6314258", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P22436", "ec_number_list": "", "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042571 immunoglobulin complex, circulating", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P03987-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C6B7-1", "uniprot_id": "IGSF6_MOUSE", "mass": 26354.0, "length": 237, "protein_name": "Immunoglobulin superfamily member 6", "gene_name": "Igsf6", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily member 6 precursor", "refseq_ac": "NP_109616", "gene_names_uniprotkb": "Igsf6", "gene_names_refseq": "Igsf6", "protein_names_uniprotkb": "Immunoglobulin superfamily member 6; IgSF6", "protein_names_refseq": "immunoglobulin superfamily member 6 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:80719)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11132146;16837177;26740625", "class_list": "", "function": "The IGSF6 expression is different in mouse embryos of the different ages. In situ hybridization performed on mice embryos sections showed the differential presence of IGSF6 in developing lung and kidney., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C6B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DOV1-1", "uniprot_id": "IFI5B_MOUSE", "mass": 46977.0, "length": 425, "protein_name": "Interferon-activable protein 211", "gene_name": "Ifi211", "organism": "Mouse", "refseq_name": "interferon-activable protein 211 isoform 1", "refseq_ac": "NP_001028622", "gene_names_uniprotkb": "Ifi211; Ifi205b; Mnda; p205", "gene_names_refseq": "A730048F03; Ifi205b; Ifi211; Mnda; ifi-205-B", "protein_names_uniprotkb": "Interferon-activable protein 211; Ifi-205-B; Interferon-activable protein 205-B; Interferon-inducible protein p205-B; Myeloid cell nuclear differentiation antigen; Protein D3", "protein_names_refseq": "interferon-activable protein 205-B; interferon-activable protein 211 isoform 1; interferon-activable protein 211; interferon-inducible protein p205-B; lipopolysaccharide-inducible; myeloid cell nuclear differentiation antigen; protein D3", "tax_id": 10090, "disease": "", "pathway": " (mmu:381308); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15342947;16458891;22645316;23145002;25428506;30084848;31599954;37507081;7684766", "class_list": "", "function": "Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways (PubMed:15342947, PubMed:16458891). May work in synergy with TP53 to promote the transcription of CDKN1A/P21 (PubMed:16458891)., [UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a member of the interferon-regulated 200 family of proteins, which contain an N-terminal pyrin domain that is proposed to function in cell death and a partially conserved 220 amino acid domain. Expression of this protein in embryonic stem cells is critical for the DNA damage response and regulation of cell survival. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]., [RefSeq]; The role of Mnda in response to apoptosis and genotoxic stress is discussed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNS3;P15092;Q08619;Q3TM07;Q3U776;Q3U7F4;Q3U7K5;Q3UCH9;Q8C4X3;Q921V9", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0002218 activation of innate immune response;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P0DOV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20764-1", "uniprot_id": "IGLL1_MOUSE", "mass": 22772.0, "length": 209, "protein_name": "Immunoglobulin lambda-like polypeptide 1", "gene_name": "Igll1", "organism": "Mouse", "refseq_name": "immunoglobulin lambda-like polypeptide 1 precursor", "refseq_ac": "NP_001177254", "gene_names_uniprotkb": "Igll1; Igl-5", "gene_names_refseq": "Igl-5; Igll1; Igll; Lambda5", "protein_names_uniprotkb": "Immunoglobulin lambda-like polypeptide 1; CD179 antigen-like family member B; Ig lambda-5", "protein_names_refseq": "CD179 antigen-like family member B; ig lambda-5; immunoglobulin lambda chain 5; immunoglobulin lambda-like polypeptide 1 precursor; lambda 5", "tax_id": 10090, "disease": "agammaglobulinemia 2 (Disease Ontology:DOID:0081135)", "pathway": " (mmu:16136); (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 16, "publication_count": 3, "publication_id_list": "15950724;29907570;3024017", "class_list": "", "function": "Critical for B-cell development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMX0;Q5W1K3", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P20764-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52787-1", "uniprot_id": "IF_MOUSE", "mass": 45497.0, "length": 417, "protein_name": "Cobalamin binding intrinsic factor", "gene_name": "Cblif", "organism": "Mouse", "refseq_name": "cobalamin binding intrinsic factor precursor", "refseq_ac": "NP_032144", "gene_names_uniprotkb": "Cblif; Gif", "gene_names_refseq": "Cblif; Gif; IF; INF", "protein_names_uniprotkb": "Cobalamin binding intrinsic factor; Gastric intrinsic factor; IF; INF; Intrinsic factor", "protein_names_refseq": "cobalamin binding intrinsic factor precursor; gastric intrinsic factor; intrinsic factor", "tax_id": 10090, "disease": "congenital intrinsic factor deficiency (Disease Ontology:DOID:0050734); gastric ulcer (Disease Ontology:DOID:10808); pernicious anemia (Disease Ontology:DOID:13381); gastritis (Disease Ontology:DOID:4029)", "pathway": " (mmu:14603); (R-MMU-9758881)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8253786", "class_list": "", "function": "Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5C1", "ec_number_list": "", "go_molecular_function": "GO:0031419 cobalamin binding;GO:0140355 cargo receptor ligand activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0016324 apical plasma membrane;GO:0005902 microvillus", "go_biological_process": "GO:0015889 cobalamin transport;GO:0006824 cobalt ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P52787-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04997-1", "uniprot_id": "INHA_MOUSE", "mass": 39550.0, "length": 366, "protein_name": "Inhibin alpha chain", "gene_name": "Inha", "organism": "Mouse", "refseq_name": "inhibin alpha chain isoform 1 preproprotein", "refseq_ac": "NP_034694", "gene_names_uniprotkb": "Inha", "gene_names_refseq": "Inha", "protein_names_uniprotkb": "Inhibin alpha chain", "protein_names_refseq": "inhibin alpha chain isoform 1 preproprotein; inhibin alpha chain", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); Leydig cell tumor (Disease Ontology:DOID:2696); Sertoli-Leydig cell tumor (Disease Ontology:DOID:2997); invasive ductal carcinoma (Disease Ontology:DOID:3008); embryonal carcinoma (Disease Ontology:DOID:3308); seminoma (Disease Ontology:DOID:4440); dysgerminoma (Disease Ontology:DOID:4441)", "pathway": " (mmu:16322); (R-MMU-1502540); (R-MMU-201451); (R-MMU-209822); (R-MMU-9839406)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "1448148;1632772;2253839;35820727;8090730;8330535;8701077", "class_list": "", "function": "Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor., [UniProtKB, UniProtKB]; Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mice in which this gene has been ablated exhibit sex cord-stromal tumors and symptoms that mimic the human cancer cachexia syndrome. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTG7", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0034711 inhibin binding", "go_cellular_component": "GO:0043512 inhibin A complex;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0042127 regulation of cell population proliferation;GO:0008584 male gonad development;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q04997-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TNL8-1", "uniprot_id": "IPRI_MOUSE", "mass": 63238.0, "length": 555, "protein_name": "Inositol 1,4,5-trisphosphate receptor-interacting protein", "gene_name": "Itprip", "organism": "Mouse", "refseq_name": "inositol 1,4,5-trisphosphate receptor-interacting protein precursor", "refseq_ac": "NP_001001738", "gene_names_uniprotkb": "Itprip; Kiaa1754", "gene_names_refseq": "4833424O12Rik; DANGER; Itprip", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor-interacting protein", "protein_names_refseq": "inositol 1,4,5-trisphosphate receptor-interacting protein precursor; inositol 1,4,5-trisphosphate receptor-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:414801)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;20053891;21750661;26429502;31142202", "class_list": "", "function": "DANGER-deficient mouse embryonic fibroblasts and neurons exhibit greater death-associated protein kinase activity and increased sensitivity to cell death., [RefSeq, PubMed]; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release., [UniProtKB, UniProtKB]; Novel Macrophage Activated Associated Protein 1 NP_001001738) is an essential molecule that modulates macrophages phenotype and plays an important role in macrophage tumoricidal functions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAD9;Q3TB01;Q571G7;Q6P400", "ec_number_list": "", "go_molecular_function": "GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3TNL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V3R4-1", "uniprot_id": "ITA1_MOUSE", "mass": 130810.0, "length": 1179, "protein_name": "Integrin alpha-1", "gene_name": "Itga1", "organism": "Mouse", "refseq_name": "integrin alpha-1 precursor", "refseq_ac": "NP_001028400", "gene_names_uniprotkb": "Itga1", "gene_names_refseq": "CD49A; E130012M19Rik; Itga1; Vla1", "protein_names_uniprotkb": "Integrin alpha-1; CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1", "protein_names_refseq": "CD49 antigen-like family member A; VLA-1; integrin alpha-1 precursor; laminin and collagen receptor", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:109700); (R-MMU-216083); (R-MMU-445355)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15592458;27802388;29187734;30899004;31219806;31616917;33584706;34418053;34428180", "class_list": "", "function": "Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth., [UniProtKB, PubMed]; VLA-1 Binding to Collagen IV Controls Effector T Cell Suppression by Myeloid-Derived Suppressor Cells in the Splenic Red Pulp. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 14, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 14, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 14, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 14, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 18, "disease_count": 1, "glyco_site_count": 25, "binding_glycan_count": 0, "secondary_ac_list": "F8VQN5", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0005518 collagen binding;GO:0019903 protein phosphatase binding;GO:0019211 phosphatase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0043204 perikaryon;GO:0045178 basal part of cell", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "Q3V3R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62470-1", "uniprot_id": "ITA3_MOUSE", "mass": 116745.0, "length": 1053, "protein_name": "Integrin alpha-3", "gene_name": "Itga3", "organism": "Mouse", "refseq_name": "integrin alpha-3 isoform 2", "refseq_ac": "NP_001293000", "gene_names_uniprotkb": "Itga3", "gene_names_refseq": "CD49C; GAPB3; Itga3", "protein_names_uniprotkb": "Integrin alpha-3; CD49 antigen-like family member C; GAPB3; Galactoprotein B3; VLA-3 subunit alpha", "protein_names_refseq": "CD49 antigen-like family member C; VLA-3 receptor, alpha 3 subunit; galactoprotein B3; integrin alpha-3 isoform 2", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); glomerulonephritis (Disease Ontology:DOID:2921); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:16400); (R-MMU-210991); (R-MMU-216083); (R-MMU-8874081)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15181153;19349973;1946438;19656770;21750661;25428506;30899004;31219806;34428180;35820727;38755258;7759572", "class_list": "glycogene;glycosyltransferase", "function": "Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis., [RefSeq, PubMed]; Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration., [UniProtKB, UniProtKB]; This gene encodes a subunit of integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded protein non-covalently associates with the integrin beta-1 subunit to form a heterodimer that interacts with many extracellular matrix proteins including fibronectin and laminin. Mice lacking the encoded protein die during the first day after birth due to severe abnormalities in kidneys. Mice lacking the encoded protein specifically in the basal layer of epidermis display several skin defects and accelerated wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 16, "disease_count": 5, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q08441;Q08442;Q5SWA8;Q5SWB9;Q6P6I1", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0019904 protein domain specific binding;GO:0046982 protein heterodimerization activity;GO:0005518 collagen binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0072006 nephron development;GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q62470-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64282-1", "uniprot_id": "IFIT1_MOUSE", "mass": 53737.0, "length": 463, "protein_name": "Antiviral innate immune response effector IFIT1", "gene_name": "Ifit1", "organism": "Mouse", "refseq_name": "antiviral innate immune response effector IFIT1", "refseq_ac": "NP_032357", "gene_names_uniprotkb": "Ifit1; Garg16; Ifi56; Ifit1b; Isg56", "gene_names_refseq": "GARG-16; IFI-56K; ISG56; Ifi56; Ifit1; P56", "protein_names_uniprotkb": "Antiviral innate immune response effector IFIT1; GARG-16; Glucocorticoid-attenuated response gene 16 protein; IFI-56K; IFIT-1; Interferon-induced 56 kDa protein; Interferon-induced protein with tetratricopeptide repeats 1; P56", "protein_names_refseq": "antiviral innate immune response effector IFIT1; glucocorticoid-attenuated response gene 16 protein; interferon-induced 56 kDa protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:15957)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15561726;16023166;19856081;20950130;21085181;22589727;25605945;27240734;31219806;33454014;34428180;7896268;8660659", "class_list": "", "function": "Block different functions of eIF3 by binding to its different subunits., [RefSeq, PubMed]; Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L77", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0004857 enzyme inhibitor activity;GO:0140610 RNA sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0009617 response to bacterium;GO:0009615 response to virus;GO:0071345 cellular response to cytokine stimulus;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64282-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PKN7-1", "uniprot_id": "INCA1_MOUSE", "mass": 26477.0, "length": 231, "protein_name": "Protein INCA1", "gene_name": "Inca1", "organism": "Mouse", "refseq_name": "protein INCA1 isoform 1", "refseq_ac": "NP_001239411", "gene_names_uniprotkb": "Inca1", "gene_names_refseq": "Inca1", "protein_names_uniprotkb": "Protein INCA1; Inhibitor of CDK interacting with cyclin A1", "protein_names_refseq": "inhibitor of CDK interacting with cyclin A1; protein INCA1 isoform 1; protein INCA1", "tax_id": 10090, "disease": "", "pathway": " (mmu:103844)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15159402;21540187;21750715;25525809", "class_list": "", "function": "Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and proliferation and may play a role in cell cycle control (PubMed:21540187). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (PubMed:21750715)., [UniProtKB, PubMed, PubMed]; Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling, [RefSeq, PubMed]; Results showed that absence of Inca1 mildly affects normal hematopoiesis under homeostatic conditions but controls hematopoiesis after induction of cytotoxic stress and plays a role in the maintenance of leukemia development in acute myeloid leukemia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4VAE2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PKN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TT16-1", "uniprot_id": "IPMK_MOUSE", "mass": 44453.0, "length": 396, "protein_name": "Inositol polyphosphate multikinase", "gene_name": "Ipmk", "organism": "Mouse", "refseq_name": "inositol polyphosphate multikinase isoform 2", "refseq_ac": "NP_001334120", "gene_names_uniprotkb": "Ipmk; Impk; Ipk2", "gene_names_refseq": "2410017C19Rik; Impk; Ipmk", "protein_names_uniprotkb": "Inositol polyphosphate multikinase; 2.7.1.140; 2.7.1.151; 2.7.1.153; Inositol 1,3,4,6-tetrakisphosphate 5-kinase", "protein_names_refseq": "inositol 1,3,4,6-tetrakisphosphate 5-kinase; inositol polyphosphate multikinase isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69718); (R-MMU-1855191)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15939867;21183079;21750661;22203993;36830701;37795573;39478550", "class_list": "", "function": "A non-catalytic role of IPMK is required for PLCgamma1 activation in T cell receptor signaling by stabilizing the PLCgamma1-Sam68 complex. Publication Status: Online-Only, [RefSeq, PubMed]; Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:15939867). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (By similarity). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (PubMed:15939867)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Inositol polyphosphate multikinase (Ipk2) plays a major role in the synthesis of inositol polyphosphate messengers derived from inositol 1,4,5-trisphosphate in embryogenesis and normal development., [RefSeq, PubMed]; Inositol polyphosphate multikinase modulates free fatty acids-induced insulin resistance in primary mouse hepatocytes., [RefSeq, PubMed]; MiRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ11;Q8BZA8;Q9CWM9", "ec_number_list": "2.7.1.153;2.7.1.137;2.7.11.1;2.7.1.154;2.7.-.-;2.7.1.151;2.7.1.140", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity;GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0036064 ciliary basal body", "go_biological_process": "GO:0046488 phosphatidylinositol metabolic process;GO:0070266 necroptotic process;GO:0032957 inositol trisphosphate metabolic process;GO:0032958 inositol phosphate biosynthetic process;GO:0001841 neural tube formation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TT16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VY2-1", "uniprot_id": "INKA2_MOUSE", "mass": 33233.0, "length": 300, "protein_name": "PAK4-inhibitor INKA2", "gene_name": "Inka2", "organism": "Mouse", "refseq_name": "PAK4-inhibitor INKA2 isoform 2", "refseq_ac": "NP_001156828", "gene_names_uniprotkb": "Inka2; Fam212b", "gene_names_refseq": "6530418L21Rik; Fam212b; Inka2", "protein_names_uniprotkb": "PAK4-inhibitor INKA2; Induced in neural crest by AP2-alpha protein-related homolog; MInca-r", "protein_names_refseq": "MInca-r; PAK4-inhibitor INKA2 isoform 2; PAK4-inhibitor INKA2; family with sequence similarity 212, member B; induced in neural crest by AP2-alpha protein-related homolog; protein FAM212B", "tax_id": 10090, "disease": "", "pathway": " (mmu:109050)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17314132;26292052;31975032;36301793;36586159", "class_list": "", "function": "Control of cell migration by the novel protein phosphatase-2A interacting protein inka2., [RefSeq, PubMed]; In the present study, we identified a novel gene, designated as inka2, which is related to inka1, [RefSeq, PubMed]; Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity., [UniProtKB, UniProtKB]; Inka2 expression in smooth muscle cells and its involvement in cell migration., [RefSeq, PubMed]; Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5H0;Q8CCA1", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80VY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZA0-1", "uniprot_id": "ITL1B_MOUSE", "mass": 35070.0, "length": 313, "protein_name": "Intelectin-1b", "gene_name": "Itln1b", "organism": "Mouse", "refseq_name": "intelectin-1b precursor", "refseq_ac": "NP_001007553", "gene_names_uniprotkb": "Itln1b; Itln2; Itlnb", "gene_names_refseq": "Itln1b; Itln2; Itlnb", "protein_names_uniprotkb": "Intelectin-1b; Intelectin-2", "protein_names_refseq": "intelectin-1b precursor; intelectin-1b; intelectin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:493583)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15048991;15265922;17420014;21349217", "class_list": "glycogene", "function": "Itlnb is increased in expression in the mouse intestinal tract in response to infection with Trichinella spiralis. Mice lacking the Itlnb gene cannot expulse T.spiralis as efficiently. This gene is absent in C57BL/10 mice., [RefSeq, PubMed]; May play a protective role in the innate immune response to parasite infection., [UniProtKB]; The responsiveness to Ascaris in mice is likely to be controlled by multiple genes and, despite a unique absence from the susceptible C57BL/6j strain, the Intelectin-2 gene does not play a significant role in resistance., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0009624 response to nematode", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80ZA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZF2-1", "uniprot_id": "IFNE_MOUSE", "mass": 22372.0, "length": 192, "protein_name": "Interferon epsilon", "gene_name": "Ifne", "organism": "Mouse", "refseq_name": "interferon epsilon precursor", "refseq_ac": "NP_796322", "gene_names_uniprotkb": "Ifne; Ifne1; Ifnt1", "gene_names_refseq": "If1ea; Ifn-tau-1; Ifne1; Ifne; Ifnt1; Infe1", "protein_names_uniprotkb": "Interferon epsilon; IFN-epsilon; Interferon epsilon-1; Interferon tau-1", "protein_names_refseq": "IFN-epsilon; interferon 1ea; interferon epsilon 1; interferon epsilon precursor; interferon tau-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230405)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15233997;23449591;23951133;36897927;38975675", "class_list": "", "function": "Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of Interferon Epsilon in Mucosal Epithelium is Regulated by Elf3., [RefSeq, PubMed]; IFN-epsilon is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines. Publication Status: Online-Only, [RefSeq, PubMed]; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral, including HSV-2, and bacterial, including Chlamydia muridarum, genital infections., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80ZF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGY2-1", "uniprot_id": "IF5A2_MOUSE", "mass": 16793.0, "length": 153, "protein_name": "Eukaryotic translation initiation factor 5A-2", "gene_name": "Eif5a2", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 5A-2", "refseq_ac": "NP_808254", "gene_names_uniprotkb": "Eif5a2", "gene_names_refseq": "9630038B20; Eif5a2; eIF5AII", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5A-2; Eukaryotic initiation factor 5A isoform 2; eIF-5A-2; eIF-5A2", "protein_names_refseq": "eukaryotic initiation factor 5A; eukaryotic translation initiation factor 5A-2", "tax_id": 10090, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (mmu:208691); (R-MMU-204626)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11161802;21612665;34428180;35931669;36848144;38055903;38506035", "class_list": "", "function": "A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates beta-Cell Identity and Function., [RefSeq, PubMed]; Activation of eIF-5A2 repressed p19 level and therefore destabilized p53 in transgenic mouse embryo fibroblast (MEF) cells. This subsequently allowed for the accumulation of chromosomal instability. Publication Status: Online-Only, [RefSeq, PubMed]; Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys 50. Mouse EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and eIF5AII., [RefSeq, PubMed]; Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance. Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2., [RefSeq, PubMed]; New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape., [RefSeq, PubMed]; Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BGY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQC3-1", "uniprot_id": "IGDC3_MOUSE", "mass": 86460.0, "length": 813, "protein_name": "Immunoglobulin superfamily DCC subclass member 3", "gene_name": "Igdcc3", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily DCC subclass member 3 isoform 2 precursor", "refseq_ac": "NP_033014", "gene_names_uniprotkb": "Igdcc3; Punc", "gene_names_refseq": "2810401C09Rik; Igdcc3; Punc; WI-14920", "protein_names_uniprotkb": "Immunoglobulin superfamily DCC subclass member 3; Putative neuronal cell adhesion molecule", "protein_names_refseq": "amplimer WI-14920, mouse homolog; immunoglobulin superfamily DCC subclass member 3 isoform 2 precursor; putative neuronal cell adhesion molecule", "tax_id": 10090, "disease": "", "pathway": " (mmu:19289)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "9507132;9922388", "class_list": "", "function": "", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "O70246;Q792T2;Q9Z2S6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0050885 neuromuscular process controlling balance;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BQC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K057-1", "uniprot_id": "IFT80_MOUSE", "mass": 87811.0, "length": 777, "protein_name": "Intraflagellar transport protein 80 homolog", "gene_name": "Ift80", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 80 homolog", "refseq_ac": "NP_080917", "gene_names_uniprotkb": "Ift80; Kiaa1374; Wdr56", "gene_names_refseq": "4921524P20Rik; Ift80; Wdr56; mKIAA1374", "protein_names_uniprotkb": "Intraflagellar transport protein 80 homolog; WD repeat-containing protein 56", "protein_names_refseq": "WD repeat domain 56; WD repeat-containing protein 56; intraflagellar transport 80 homolog; intraflagellar transport protein 80 homolog", "tax_id": 10090, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); ciliopathy (Disease Ontology:DOID:0060340); asphyxiating thoracic dystrophy 2 (Disease Ontology:DOID:0110086); asphyxiating thoracic dystrophy 3 (Disease Ontology:DOID:0110087)", "pathway": " (mmu:68259); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17468754;19253336;21227999;21750661;23810713;30084848;34428180;35733270", "class_list": "", "function": "An absolute requirement for Ift80 in hedgehog signalling, but low level expression permits ciliogenesis indicating separate but linked roles for this protein in formation and function., [RefSeq, PubMed]; Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia., [UniProtKB]; IFT80 negatively regulates osteoclast differentiation via association with Cbl-b to disrupt TRAF6 stabilization and activation. Erratum:[Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2212944119. doi: 10.1073/pnas.2212944119. PMID: 36083968], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPT0;Q8C9F1;Q91YV4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0030991 intraciliary transport particle A", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0033687 osteoblast proliferation;GO:0008283 cell population proliferation;GO:0021510 spinal cord development;GO:0048863 stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K057-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D168-1", "uniprot_id": "INT12_MOUSE", "mass": 48568.0, "length": 461, "protein_name": "Integrator complex subunit 12", "gene_name": "Ints12", "organism": "Mouse", "refseq_name": "integrator complex subunit 12", "refseq_ac": "NP_082203", "gene_names_uniprotkb": "Ints12; Phf22", "gene_names_refseq": "1110020M19Rik; 2810027J24Rik; 4930529N21Rik; A230056J18Rik; Ints12; Phf22; int12", "protein_names_uniprotkb": "Integrator complex subunit 12; Int12; PHD finger protein 22", "protein_names_refseq": "PHD finger protein 22; integrator complex subunit 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:71793); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;34428180;40997131", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2Q5;Q921U2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8B7-1", "uniprot_id": "JAM3_MOUSE", "mass": 34838.0, "length": 310, "protein_name": "Junctional adhesion molecule C", "gene_name": "Jam3", "organism": "Mouse", "refseq_name": "junctional adhesion molecule C precursor", "refseq_ac": "NP_075766", "gene_names_uniprotkb": "Jam3", "gene_names_refseq": "1110002N23Rik; JAM-3; JAM-C; Jam3; Jcam3", "protein_names_uniprotkb": "Junctional adhesion molecule C; JAM-2; JAM-3; JAM-C; Junctional adhesion molecule 3", "protein_names_refseq": "junction cell adhesion molecule 3; junction cell adhesion molecule C; junctional adhesion molecule 3; junctional adhesion molecule C precursor; junctional adhesion molecule C", "tax_id": 10090, "disease": "Jacobsen Syndrome (Disease Ontology:DOID:0111723); sciatic neuropathy (Disease Ontology:DOID:11446); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (mmu:83964); (R-MMU-202733); (R-MMU-216083)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11036763;11053409;11739175;12810109;15372036;15994945;16093349;16297198;19656770;20592283;24357068;25428506;28617811;30899004;34861679;38095908", "class_list": "", "function": "JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development., [RefSeq, PubMed]; Junctional adhesion molecule C expression specifies a CD138low/neg multiple myeloma cell population in mice and humans., [RefSeq, PubMed]; Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:15372036, PubMed:16093349). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (PubMed:16297198). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (PubMed:15372036, PubMed:15994945). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:16093349). Plays a role in angiogenesis (PubMed:15994945). Plays a role in the regulation of cell migration (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 8836, "biomarker_type": "", "glycan_count": 6, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BT59;Q9D1M9;Q9EPK4", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0002318 myeloid progenitor cell differentiation;GO:0033624 negative regulation of integrin activation;GO:0097241 hematopoietic stem cell migration to bone marrow;GO:0090138 regulation of actin cytoskeleton organization by cell-cell adhesion;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9D8B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBZ1-1", "uniprot_id": "IKIP_MOUSE", "mass": 42532.0, "length": 373, "protein_name": "Inhibitor of nuclear factor kappa-B kinase-interacting protein", "gene_name": "Ikbip", "organism": "Mouse", "refseq_name": "inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 2", "refseq_ac": "NP_081354", "gene_names_uniprotkb": "Ikbip; Ikip", "gene_names_refseq": "1200009F10Rik; 1700023M03Rik; Ikbip; Ikip", "protein_names_uniprotkb": "Inhibitor of nuclear factor kappa-B kinase-interacting protein; I kappa-B kinase-interacting protein; IKBKB-interacting protein; IKK-interacting protein", "protein_names_refseq": "IKK-interacting protein; i kappa-B kinase-interacting protein; inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 2; inhibitor of nuclear factor kappa-B kinase-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67454)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "Target of p53/TP53 with pro-apoptotic function., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMH1;Q8K1Z4;Q9DA09", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0032496 response to lipopolysaccharide;GO:0034612 response to tumor necrosis factor;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0070555 response to interleukin-1", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DBZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQS9-1", "uniprot_id": "IGDC4_MOUSE", "mass": 134765.0, "length": 1252, "protein_name": "Immunoglobulin superfamily DCC subclass member 4", "gene_name": "Igdcc4", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily DCC subclass member 4 isoform 1 precursor", "refseq_ac": "NP_001277244", "gene_names_uniprotkb": "Igdcc4; Ddm36; Kiaa1628; Nope", "gene_names_refseq": "DDM36; Igdcc4; Nope", "protein_names_uniprotkb": "Immunoglobulin superfamily DCC subclass member 4; Neighbor of punc e11; Protein DDM36", "protein_names_refseq": "amplimer WI-16786, mouse homolog; amplimer WI-18508, mouse homolog; immunoglobulin superfamily DCC subclass member 4 isoform 1 precursor; neighbor of Punc e11 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56741)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10708514;10997877;20658536;35246597", "class_list": "", "function": "Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival. Publication Status: Online-Only, [RefSeq, PubMed]; Identified Nope as a novel oncofetal surface marker for murine and human HCC. Nope is specifically expressed by epithelial tumor cells but not in preneoplastic stages and is a promising marker, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q80TB0;Q9EQS8;Q9JLI1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0050768 negative regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9EQS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESK4-1", "uniprot_id": "ING2_MOUSE", "mass": 32978.0, "length": 281, "protein_name": "Inhibitor of growth protein 2", "gene_name": "Ing2", "organism": "Mouse", "refseq_name": "inhibitor of growth protein 2", "refseq_ac": "NP_075992", "gene_names_uniprotkb": "Ing2; Ing1l", "gene_names_refseq": "2810011M06Rik; Ing1l; Ing2b; Ing2; P33ING2", "protein_names_uniprotkb": "Inhibitor of growth protein 2; Inhibitor of growth 1-like protein; p33ING2", "protein_names_refseq": "inhibitor of growth 1-like protein; inhibitor of growth protein 2", "tax_id": 10090, "disease": "carcinoma (Disease Ontology:DOID:305)", "pathway": " (mmu:69260); (R-MMU-3899300); (R-MMU-6811555)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16728977;25428506;25672483;26717876;30084848;32424454;34428180", "class_list": "", "function": "2.0 A resolution structure of the mouse ING2 PHD finger in complex with a histone H3 peptide trimethylated at lysine 4, [RefSeq, PubMed]; ING2 may be involved in the repair and regeneration of organs or tissues and is associated with breast and gynecological carcinogenesis., [RefSeq, PubMed]; ING2 may play a crucial role in the process of preimplantation embryo development through chromatin regulation., [RefSeq, PubMed]; Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells. Erratum:[J Physiol Biochem. 2020 Aug;76(3):483. doi: 10.1007/s13105-020-00752-2. PMID: 32562166], [RefSeq, PubMed]; Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VAD7;Q80VI5;Q8BGU8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0035091 phosphatidylinositol binding;GO:0035033 histone deacetylase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0070822 Sin3-type complex;GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0048133 male germ-line stem cell asymmetric division;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ESK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJY9-1", "uniprot_id": "IL22_MOUSE", "mass": 20106.0, "length": 179, "protein_name": "Interleukin-22", "gene_name": "Il22", "organism": "Mouse", "refseq_name": "interleukin-22 precursor", "refseq_ac": "NP_058667", "gene_names_uniprotkb": "Il22; Il22a; Iltifa; Iltif", "gene_names_refseq": "IL-22a; IL-22; ILTIFa; If2b1; Il22; Iltif", "protein_names_uniprotkb": "Interleukin-22; IL-10-related T-cell-derived-inducible factor; IL-22a; IL-22; IL-TIF alpha; IL-TIF; Interleukin-22a", "protein_names_refseq": "IL-10-related T-cell-derived-inducible factor; IL-TIF alpha; ILTIF alpha; interferon 2b1; interleukin 10-related T cell-derived inducible factor; interleukin-22 precursor; interleukin-22a", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); liposarcoma (Disease Ontology:DOID:3382); tuberculosis (Disease Ontology:DOID:399); rhinitis (Disease Ontology:DOID:4483); myocarditis (Disease Ontology:DOID:820)", "pathway": " (mmu:50929); (R-MMU-8854691)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10657629;11197690;24742671;33852830;33912578;35525330", "class_list": "", "function": "Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed:33852830, PubMed:35525330). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed:33912578). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways. Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (PubMed:24742671). Promotes epithelial cell spreading (PubMed:24742671)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q14BB3", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043235 receptor complex;GO:0140368 decoy receptor complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050728 negative regulation of inflammatory response;GO:0072593 reactive oxygen species metabolic process;GO:0042509 regulation of tyrosine phosphorylation of STAT protein", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMC2-1", "uniprot_id": "INSM2_MOUSE", "mass": 52225.0, "length": 493, "protein_name": "Insulinoma-associated protein 2", "gene_name": "Insm2", "organism": "Mouse", "refseq_name": "insulinoma-associated protein 2", "refseq_ac": "NP_064683", "gene_names_uniprotkb": "Insm2; Mlt1", "gene_names_refseq": "Insm2; Mlt1", "protein_names_uniprotkb": "Insulinoma-associated protein 2; Methylated in liver tumor 1", "protein_names_refseq": "insulinoma-associated protein 2; methylated in liver tumor 1; mlt 1", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (mmu:56856)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11221845;21343251;22785238;30359270;34428180;35786158", "class_list": "", "function": "Data suggest that IA-2 and IA-2beta play important roles in regulation of circadian rhythms, likely through their participation in neurochemical communication among neurons of suprachiasmatic nucleus., [RefSeq, PubMed]; Insm2 deficiency results in female infertility by disturbing steroid pathway and decreasing ovarian reserve in mice., [RefSeq, PubMed]; Insm2 is important in glucose-stimulated insulin secretion. Publication Status: Online-Only, [RefSeq, PubMed]; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons., [UniProtKB, PubMed]; Results suggest that Insm2 plays an important role in the differentiation cascade of Ngn3/NeuroD1 signaling in pancreatic islets., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QNA9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030182 neuron differentiation;GO:0010564 regulation of cell cycle process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JMC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUM0-1", "uniprot_id": "ITA2B_MOUSE", "mass": 112678.0, "length": 1033, "protein_name": "Integrin alpha-IIb", "gene_name": "Itga2b", "organism": "Mouse", "refseq_name": "integrin alpha-IIb precursor", "refseq_ac": "NP_034705", "gene_names_uniprotkb": "Itga2b", "gene_names_refseq": "CD41B; CD41; GpIIb; Itga2b; alphaIIb", "protein_names_uniprotkb": "Integrin alpha-IIb; GPIIb; GPalpha IIb; Platelet membrane glycoprotein IIb", "protein_names_refseq": "GP IIb; GPalpha IIb; alpha IIb; integrin alpha-IIb precursor; integrin alpha-IIb; platelet glycoprotein IIb of IIb/II Ia complex; platelet membrane glycoprotein IIb", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); von Willebrand's disease 1 (Disease Ontology:DOID:0060573); platelet-type bleeding disorder 16 (Disease Ontology:DOID:0060691); intellectual disability (Disease Ontology:DOID:1059); thrombocytopenia (Disease Ontology:DOID:1588); Glanzmann's thrombasthenia (Disease Ontology:DOID:2219); severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (mmu:16399); (R-MMU-114608); (R-MMU-216083); (R-MMU-3000178); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-445144); (R-MMU-5674135); (R-MMU-9769733)", "pathway_count": 10, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10572112;10713093;1512266;24429998;26495903;26740625;38482878;39627609", "class_list": "", "function": "Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (By similarity). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity). Integrin ITGA2B:ITGB3 is also the receptor of erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Potential Mechanism of Platelet GPIIb/IIIa and Fibrinogen on Retinal Vein Occlusion., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3R7;Q64229;Q9Z2M0", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0050840 extracellular matrix binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion;GO:0033631 cell-cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QUM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QY61-1", "uniprot_id": "IRX4_MOUSE", "mass": 54701.0, "length": 515, "protein_name": "Iroquois-class homeodomain protein IRX-4", "gene_name": "Irx4", "organism": "Mouse", "refseq_name": "iroquois-class homeodomain protein IRX-4", "refseq_ac": "NP_061373", "gene_names_uniprotkb": "Irx4; Irxa3", "gene_names_refseq": "Irx4", "protein_names_uniprotkb": "Iroquois-class homeodomain protein IRX-4; Homeodomain protein IRXA3; Iroquois homeobox protein 4", "protein_names_refseq": "Iroquois related homeobox 4; homeodomain protein IRXA3; iroquois homeobox protein 4; iroquois-class homeodomain protein IRX-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:50916)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10625552;10926765;17875669;20485683", "class_list": "", "function": "Likely to be an important mediator of ventricular differentiation during cardiac development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JNT5;Q3V1B6", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0048561 establishment of animal organ orientation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QY61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTL4-1", "uniprot_id": "INSRR_MOUSE", "mass": 144875.0, "length": 1300, "protein_name": "Insulin receptor-related protein", "gene_name": "Insrr", "organism": "Mouse", "refseq_name": "insulin receptor-related protein precursor", "refseq_ac": "NP_035962", "gene_names_uniprotkb": "Insrr; Irr", "gene_names_refseq": "Insrr; Irr", "protein_names_uniprotkb": "Insulin receptor-related protein; 2.7.10.1; IR-related receptor; IRR", "protein_names_refseq": "IR-related receptor; insulin receptor-related protein precursor; insulin receptor-related protein", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); high grade glioma (Disease Ontology:DOID:3070); glucose metabolism disease (Disease Ontology:DOID:4194); sleep disorder (Disease Ontology:DOID:535); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:23920)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10342810;11463843;14628051;21641549;28438671;30084848;30695555;36038798;39627609", "class_list": "", "function": "Changes in the Expression of the gapdh Gene in the Organs of insrr Knockout Mice., [RefSeq, PubMed]; Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB., [UniProtKB, PubMed]; The activation of IRR by alkali might be part of a local loop of signaling between the exocrine and endocrine parts of the pancreas where alkalinization of the juice facilitate insulin release that increases the volume of secreted juice to control its pH and bicabonate content., [RefSeq, PubMed]; The insulin receptor tyrosine kinase family, comprising Ir, Igf1r and Irr, is required for the appearance of male gonads and thus for male sexual differentiation, [RefSeq, PubMed]; The obtained data suggest that the IRR gene inactivation results in disturbances of the aggressive-defensive behavior typical of the parental mouse strain c57bl., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 9, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "B2RQC5", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.40;2.7.11.23", "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0043560 insulin receptor substrate binding;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043235 receptor complex;GO:0005899 insulin receptor complex", "go_biological_process": "GO:0071469 cellular response to alkaline pH;GO:0030036 actin cytoskeleton organization;GO:0046777 protein autophosphorylation;GO:0008286 insulin receptor signaling pathway;GO:0030238 male sex determination", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9WTL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ET80-1", "uniprot_id": "JPH1_MOUSE", "mass": 71905.0, "length": 660, "protein_name": "Junctophilin-1", "gene_name": "Jph1", "organism": "Mouse", "refseq_name": "junctophilin-1", "refseq_ac": "NP_065629", "gene_names_uniprotkb": "Jph1; Jp1", "gene_names_refseq": "JP-1; Jp1; Jph1", "protein_names_uniprotkb": "Junctophilin-1; JP-1; Junctophilin type 1", "protein_names_refseq": "junctophilin type 1; junctophilin-1; mitsugumin72", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); Charcot-Marie-Tooth disease axonal type 2K (Disease Ontology:DOID:0110167)", "pathway": " (mmu:57339)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10949023;11535622;12135771;12729900;14559359;21750661;25428506;29632175;31315980;31599954;35912995;39927985", "class_list": "", "function": "Abnormal junctional membrane structures in cardiac myocytes in transgenic mice expressing junctophilin type 1., [RefSeq, PubMed]; Dissociation of SH3 and cysteine-rich domain 3 and junctophilin 1 from dihydropyridine receptor in dystrophin-deficient muscles., [RefSeq, PubMed]; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes., [UniProtKB, PubMed, PubMed, PubMed]; Molecular determinants of homo- and heteromeric interactions of Junctophilin-1 at triads in adult skeletal muscle fibers., [RefSeq, PubMed]; Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction., [RefSeq, PubMed]; We report a novel Junctophilin subtype, JP-4, encoded in the human (chromosome 14q11.1) and mouse (chromosome 14C1-2) genomes. JP-4 shares characteristic structural features with other JP subtypes, and is found in the brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB08;Q9EQZ3", "ec_number_list": "", "go_molecular_function": "GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030018 Z disc", "go_biological_process": "GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9ET80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D256-1", "uniprot_id": "ISK12_MOUSE", "mass": 9353.0, "length": 87, "protein_name": "Serine protease inhibitor Kazal-type 12", "gene_name": "Spink12", "organism": "Mouse", "refseq_name": "serine protease inhibitor Kazal-type 12 precursor", "refseq_ac": "NP_084337", "gene_names_uniprotkb": "Spink12", "gene_names_refseq": "9230117E20Rik; Spink12", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 12", "protein_names_refseq": "serine peptidase inhibitor, Kazal type 11; serine protease inhibitor Kazal-type 12 precursor; serine protease inhibitor Kazal-type 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:78242)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16930550;21750661;21899598", "class_list": "", "function": "Inhibits trypsin., [UniProtKB, PubMed]; Spink12 is especially expressed in the epidermal areas with thick skin and its regulation generally responds to differentiation signals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D256-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0E1-1", "uniprot_id": "KCD15_MOUSE", "mass": 31886.0, "length": 283, "protein_name": "BTB/POZ domain-containing protein KCTD15", "gene_name": "Kctd15", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD15", "refseq_ac": "NP_666300", "gene_names_uniprotkb": "Kctd15", "gene_names_refseq": "Kctd15", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD15; Potassium channel tetramerization domain-containing protein 15", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD15; potassium channel tetramerization domain-containing protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:233107)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15345747;21183079;21750661;25187989;29665387", "class_list": "", "function": "During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The physiological role played by the complex KCTD15-GRP78 in the adipogenesis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9630, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K0E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89109-1", "uniprot_id": "KCNN4_MOUSE", "mass": 47784.0, "length": 425, "protein_name": "Intermediate conductance calcium-activated potassium channel protein 4", "gene_name": "Kcnn4", "organism": "Mouse", "refseq_name": "intermediate conductance calcium-activated potassium channel protein 4 isoform a", "refseq_ac": "NP_001156982", "gene_names_uniprotkb": "Kcnn4", "gene_names_refseq": "IK1; IKCA1; KCA4; KCa3.1; Kcnn4; SK4; SKCas; mIK1; mIKCa1; mKCa4", "protein_names_uniprotkb": "Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; SK4; SKCa 4; SKCa4; mIK1; mKCa4", "protein_names_refseq": "SKCa 4; SKCa4; intermediate conductance calcium-activated potassium channel protein 4 isoform a; intermediate conductance calcium-activated potassium channel protein 4", "tax_id": 10090, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); dehydrated hereditary stomatocytosis 2 (Disease Ontology:DOID:0111577); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); brain edema (Disease Ontology:DOID:4724); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:16534); (R-MMU-1296052)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12882916;20884616;21750661;25605945;31219806;36210013;36951065;38134241;38334149;9705284", "class_list": "", "function": "Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis., [RefSeq, PubMed]; Intermediate conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:20884616, PubMed:9705284). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 25 picosiemens (PubMed:20884616, PubMed:9705284). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:9705284). Controls calcium influx during vascular contractility by being responsible of membrane hyperpolarization induced by vasoactive factors in proliferative vascular smooth muscle cell types (By similarity). Following calcium influx, the consecutive activation of KCNN4 channel leads to a hyperpolarization of the cell membrane potential and hence an increase of the electrical driving force for further calcium influx promoting sustained calcium entry in response to stimulation with chemotactic peptides (By similarity). Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:20884616). Plays a role in the late stages of EGF-induced macropinocytosis through activation by PI(3)P (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation., [RefSeq, PubMed]; M2 macrophage-derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL-1 myocytes via the NF-kappaB (p65)/STAT3 signaling pathway., [RefSeq, PubMed]; SK1, -2, -3, and IK1 (SK4) are expressed in islet cells and insulin-secreting cells and are able to influence glucose-induced calcium responses, thereby regulating insulin secretion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1J8;Q9CY39", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042803 protein homodimerization activity;GO:0005267 potassium channel activity;GO:0019903 protein phosphatase binding;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030322 stabilization of membrane potential;GO:0046541 saliva secretion;GO:0051289 protein homotetramerization;GO:1903980 positive regulation of microglial cell activation;GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O89109-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR30-1", "uniprot_id": "JOS2_MOUSE", "mass": 20776.0, "length": 188, "protein_name": "Josephin-2", "gene_name": "Josd2", "organism": "Mouse", "refseq_name": "josephin-2 isoform a", "refseq_ac": "NP_001191999", "gene_names_uniprotkb": "Josd2", "gene_names_refseq": "1110007C05Rik; Josd2", "protein_names_uniprotkb": "Josephin-2; 3.4.19.12; Josephin domain-containing protein 2", "protein_names_refseq": "josephin domain-containing protein 2; josephin-2 isoform a; josephin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66124); (R-MMU-5689877)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12486728;21750661;34428180;39195964", "class_list": "", "function": "Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme (By similarity)., [UniProtKB]; Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes., [RefSeq, PubMed]; Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CR30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZN3-1", "uniprot_id": "KCJ14_MOUSE", "mass": 47607.0, "length": 434, "protein_name": "ATP-sensitive inward rectifier potassium channel 14", "gene_name": "Kcnj14", "organism": "Mouse", "refseq_name": "ATP-sensitive inward rectifier potassium channel 14", "refseq_ac": "NP_666075", "gene_names_uniprotkb": "Kcnj14; Irk4", "gene_names_refseq": "A930026G01Rik; IRK4; Kcnj14; Kir2.4", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 14; IRK-4; Inward rectifier K(+) channel Kir2.4; Potassium channel, inwardly rectifying subfamily J member 14", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 14; IRK-4; inward rectifier K(+) channel Kir2.4; potassium channel, inwardly rectifying subfamily J member 14", "tax_id": 10090, "disease": "EAST syndrome (Disease Ontology:DOID:0060484)", "pathway": " (mmu:211480); (R-MMU-1296053); (R-MMU-5576886)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;23339194;25428506", "class_list": "", "function": "Data indicate that rectifying potassium channel Kir2.4 interacts with G-protein subunit Galphao., [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMK3;Q8BXM0", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JZN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70434-1", "uniprot_id": "IRF7_MOUSE", "mass": 51222.0, "length": 457, "protein_name": "Interferon regulatory factor 7", "gene_name": "Irf7", "organism": "Mouse", "refseq_name": "interferon regulatory factor 7 isoform 1", "refseq_ac": "NP_058546", "gene_names_uniprotkb": "Irf7", "gene_names_refseq": "Irf7", "protein_names_uniprotkb": "Interferon regulatory factor 7; IRF-7", "protein_names_refseq": "IRF-7; interferon regulatory factor 7 isoform 1", "tax_id": 10090, "disease": "immunodeficiency 39 (Disease Ontology:DOID:0111969)", "pathway": " (mmu:54123); (R-MMU-3134963); (R-MMU-9013973); (R-MMU-918233); (R-MMU-933541); (R-MMU-936964); (R-MMU-975110)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "11846980;15361868;15492225;15743772;15800576;16846591;16979567;18562536;20049431;21490621;21750661;22095711;23956435;27129230;30131810", "class_list": "", "function": "Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22095711, PubMed:27129230). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (PubMed:27129230). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; TLR-mediated IFN-alpha induction requires the formation of a complex consisting of MyD88, TRAF6 and IRF7 as well as TRAF6-dependent ubiquitination., [RefSeq, PubMed]; Transcription factor IRF-7 interacts with MyD88 to form a complex in the cytoplasm, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0034127 regulation of MyD88-independent toll-like receptor signaling pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P70434-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q811J3-1", "uniprot_id": "IREB2_MOUSE", "mass": 104920.0, "length": 963, "protein_name": "Iron-responsive element-binding protein 2", "gene_name": "Ireb2", "organism": "Mouse", "refseq_name": "iron-responsive element-binding protein 2 isoform 1", "refseq_ac": "NP_073146", "gene_names_uniprotkb": "Ireb2; Irp2", "gene_names_refseq": "D9Ertd85e; Ireb2; Irp2", "protein_names_uniprotkb": "Iron-responsive element-binding protein 2; IRE-BP 2; IRP2; Iron regulatory protein 2", "protein_names_refseq": "IRE-BP 2; iron regulatory protein 2; iron-responsive element-binding protein 2 isoform 1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); iron deficiency anemia (Disease Ontology:DOID:11758); porphyria (Disease Ontology:DOID:13268); hyperinsulinism (Disease Ontology:DOID:2018); anemia (Disease Ontology:DOID:2355); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:64602); (R-MMU-917937)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "21750661;22872234;23891004;25428506;30084848;31219806;34428180;37507081;38301068;38773499;39047035;9380695", "class_list": "", "function": "Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms. Publication Status: Online-Only, [RefSeq, PubMed]; Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages., [RefSeq, PubMed]; Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPM2;O70235", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0001069 regulatory region RNA binding;GO:0003723 RNA binding;GO:0003994 aconitate hydratase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0006417 regulation of translation;GO:0006879 intracellular iron ion homeostasis;GO:0071456 cellular response to hypoxia;GO:0050892 intestinal absorption", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q811J3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GU68-1", "uniprot_id": "ISLR_MOUSE", "mass": 45615.0, "length": 428, "protein_name": "Immunoglobulin superfamily containing leucine-rich repeat protein", "gene_name": "Islr", "organism": "Mouse", "refseq_name": "immunoglobulin superfamily containing leucine-rich repeat protein precursor", "refseq_ac": "NP_001182360", "gene_names_uniprotkb": "Islr", "gene_names_refseq": "Islr; Meflin", "protein_names_uniprotkb": "Immunoglobulin superfamily containing leucine-rich repeat protein", "protein_names_refseq": "immunoglobulin superfamily containing leucine-rich repeat protein precursor; immunoglobulin superfamily containing leucine-rich repeat protein; mesenchymal stromal cell- and fibroblast-expressing Linx paralogue", "tax_id": 10090, "disease": "", "pathway": " (mmu:26968); (R-MMU-114608)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10512678;19656770;21750661;37828378;38597911", "class_list": "", "function": "Islr regulates satellite cells asymmetric division through the SPARC/p-ERK1/2 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9343, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6GU68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVP5-1", "uniprot_id": "KC1G2_MOUSE", "mass": 47582.0, "length": 415, "protein_name": "Casein kinase I isoform gamma-2", "gene_name": "Csnk1g2", "organism": "Mouse", "refseq_name": "casein kinase I isoform gamma-2 isoform 2", "refseq_ac": "NP_001153063", "gene_names_uniprotkb": "Csnk1g2; Ck1g2", "gene_names_refseq": "2810429I12Rik; Csnk1g2", "protein_names_uniprotkb": "Casein kinase I isoform gamma-2; 2.7.11.1; CKI-gamma 2", "protein_names_refseq": "CKI-gamma 2; casein kinase I isoform gamma-2 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:103236)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15077195;16014721;21750661;22872234;26495903;33206046;34428180", "class_list": "", "function": "CKI-gamma2 could further potentiate the ER corepressive function of MTA1s. Kinase dead CK1-gamma2 could not repress estrogen-induced ER transactivation functions., [RefSeq, PubMed]; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates MTA1 (PubMed:15077195). Phosphorylates COL4A3BP/CERT and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (By similarity). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (PubMed:16014721). Involved in regulation of reactive oxygen species (ROS) levels (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0046777 protein autophosphorylation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BVP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1L317-1", "uniprot_id": "K1C24_MOUSE", "mass": 54041.0, "length": 512, "protein_name": "Keratin, type I cytoskeletal 24", "gene_name": "Krt24", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 24", "refseq_ac": "NP_083669", "gene_names_uniprotkb": "Krt24; Ka24", "gene_names_refseq": "2310058N18Rik; 2310075C18Rik; CK-24; K24; Krt24", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 24; CK-24; Cytokeratin-24; K24; Keratin-24; Type I keratin-24", "protein_names_refseq": "cytokeratin-24; keratin, type I cytoskeletal 24; ortholog of keratin 24 KRT24; type I keratin-24", "tax_id": 10090, "disease": "", "pathway": " (mmu:75706); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L316;Q8BKC6", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A1L317-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWG4-1", "uniprot_id": "K1755_MOUSE", "mass": 129087.0, "length": 1187, "protein_name": "Uncharacterized protein KIAA1755 homolog", "gene_name": "D630003M21Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein KIAA1755 homolog isoform 2", "refseq_ac": "NP_001124493", "gene_names_uniprotkb": "D630003M21Rik", "gene_names_refseq": "D630003M21Rik", "protein_names_uniprotkb": "Uncharacterized protein KIAA1755 homolog", "protein_names_refseq": "uncharacterized protein KIAA1755 homolog isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:228846)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AC61;B2RQJ6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BWG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPR4-1", "uniprot_id": "KCNT1_MOUSE", "mass": 138106.0, "length": 1224, "protein_name": "Potassium channel subfamily T member 1", "gene_name": "Kcnt1", "organism": "Mouse", "refseq_name": "potassium channel subfamily T member 1 isoform 2", "refseq_ac": "NP_001138875", "gene_names_uniprotkb": "Kcnt1; Kiaa1422; Slack; Slo2.2", "gene_names_refseq": "C030030G16Rik; Kcnt1; Slack; Slo2.2; slo2", "protein_names_uniprotkb": "Potassium channel subfamily T member 1", "protein_names_refseq": "potassium channel subfamily T member 1 isoform 2; potassium channel subunit homolog; sodium-activated potassium channel", "tax_id": 10090, "disease": "autosomal dominant nocturnal frontal lobe epilepsy 5 (Disease Ontology:DOID:0060686); developmental and epileptic encephalopathy 14 (Disease Ontology:DOID:0080439); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:227632)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;14559234;16446508;17344399;18787033;20512134;21750661;25609627;26559620;29124216;32081855;34664085;38457342", "class_list": "", "function": "Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons., [RefSeq, PubMed]; Partly colocalized with PSD-95 in mouse neocortical neurons, [RefSeq, PubMed]; Slick and Slack are expressed at high levels auditory brainstem. Activation of these KNa channels allows temporal accuracy of firing to be increased at high frequencies of stimulation., [RefSeq, PubMed]; Sodium-activated K(+) channel (PubMed:26559620). Acts as an important mediator of neuronal membrane excitability (By similarity). Contributes to the delayed outward currents (By similarity). Regulates neuronal bursting in sensory neurons (PubMed:25609627, PubMed:26559620). Contributes to synaptic development and plasticity (PubMed:32081855, PubMed:34664085)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the Slo potassium channel family that has shown to be activated by both sodium and chloride ions. This channel represents the largest potassium channel subunit yet identified. This channel may be important in development and pain signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]; This is the first demonstration of an epithelial cell membrane, Na+-activated, large-conductance K+ channel resembling K(Na) channels of excitable cells. The Slo2.2 type, Na+- and Cl--activated K+ channel is located in the ascending limb of the kidney., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RUK3;C0KTP6;Q8C3E7", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0046872 metal ion binding;GO:0005267 potassium channel activity;GO:0005228 intracellular sodium-activated potassium channel activity;GO:0070089 chloride-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane;GO:0016020 membrane", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport;GO:0060078 regulation of postsynaptic membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6ZPR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYK9-1", "uniprot_id": "KCC1B_MOUSE", "mass": 38519.0, "length": 343, "protein_name": "Calcium/calmodulin-dependent protein kinase type 1B", "gene_name": "Pnck", "organism": "Mouse", "refseq_name": "calcium/calmodulin-dependent protein kinase type 1B", "refseq_ac": "NP_001186280", "gene_names_uniprotkb": "Pnck", "gene_names_refseq": "Bstk3; CaMKIbeta2; CaMKlb2; Camk1b; Pnck; Punc; caMKlb1", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type 1B; 2.7.11.17; CaM kinase I beta; CaM kinase IB; CaM-KI beta; CaMKI-beta; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog", "protein_names_refseq": "caM kinase I beta; caM kinase IB; caM-KI beta; caMKI-beta; calcium/calmodulin-dependent protein kinase 1, beta; calcium/calmodulin-dependent protein kinase type 1B; pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:93843)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10537072;10673339;21183079;21750661", "class_list": "", "function": "Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80W07", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QYK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWS4-1", "uniprot_id": "INT11_MOUSE", "mass": 67844.0, "length": 600, "protein_name": "Integrator complex subunit 11", "gene_name": "Ints11", "organism": "Mouse", "refseq_name": "integrator complex subunit 11", "refseq_ac": "NP_082296", "gene_names_uniprotkb": "Ints11; Cpsf3l", "gene_names_refseq": "2410006F12Rik; Cpsf3l; Ints11", "protein_names_uniprotkb": "Integrator complex subunit 11; 3.1.27.-; CPSF3-like protein; Cleavage and polyadenylation-specific factor 3-like protein; Int11", "protein_names_refseq": "CPSF3-like protein; cleavage and polyadenylation specific factor 3-like; cleavage and polyadenylation-specific factor 3-like protein; int11; integrator complex subunit 11", "tax_id": 10090, "disease": "neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities (Disease Ontology:DOID:0081387)", "pathway": " (mmu:71957); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;25428506;30084848;31156619;31219806;36309014", "class_list": "", "function": "RNA endonuclease component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:36309014). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (By similarity). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (By similarity). Within the integrator complex, INTS11 constitutes the RNA endonuclease subunit that degrades exiting nascent RNA transcripts (PubMed:36309014). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ34;Q3U7B0;Q91X99;Q922F0", "ec_number_list": "3.1.13.-;2.7.7.48;2.7.7.6;2.3.1.48;2.7.11.22;2.7.11.23;2.7.11.24;3.1.3.16;3.1.27.-", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032039 integrator complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CWS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RQA1-1", "uniprot_id": "KCA10_MOUSE", "mass": 57968.0, "length": 511, "protein_name": "Potassium voltage-gated channel subfamily A member 10", "gene_name": "Kcna10", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily A member 10", "refseq_ac": "NP_001074609", "gene_names_uniprotkb": "Kcna10", "gene_names_refseq": "Gm1962; Kcna10; Kcna8; Kv1.8", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 10; Voltage-gated potassium channel subunit Kv1.8", "protein_names_refseq": "cyclic GMP gated potassium channel; potassium voltage gated channel, shaker related subfamily, member 8; potassium voltage-gated channel subfamily A member 10; voltage-gated potassium channel subunit Kv1.8", "tax_id": 10090, "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); epilepsy (Disease Ontology:DOID:1826); vestibular disease (Disease Ontology:DOID:3426)", "pathway": " (mmu:242151); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22446089;23528307", "class_list": "", "function": "Kcna10 is expressed primarily in hair cells of the inner ear and null mutations cause significant vestibular/mild hearing dysfunction. Erratum:[Hear Res. 2013 Aug;302:83], [RefSeq, PubMed]; Kcna10 is most strikingly expressed in the hair cells in late embryonic stage however, at adult stages, however, Kcna10 expression is no longer specific to hair cells., [RefSeq, PubMed]; Voltage-gated potassium ion channel that mediates K(+) permeability of excitable membranes. When opened in response to the voltage difference across the membrane, KCNA10 channel selectively allows the flow of potassium ions across the membrane down their electrochemical gradient., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RXZ4", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B2RQA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88932-1", "uniprot_id": "KCJ15_MOUSE", "mass": 42605.0, "length": 375, "protein_name": "ATP-sensitive inward rectifier potassium channel 15", "gene_name": "Kcnj15", "organism": "Mouse", "refseq_name": "ATP-sensitive inward rectifier potassium channel 15 isoform b", "refseq_ac": "NP_001034145", "gene_names_uniprotkb": "Kcnj15", "gene_names_refseq": "4930414N08Rik; IRKK; Kcnj15; Kir4.2", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 15; Inward rectifier K(+) channel Kir4.2; Potassium channel, inwardly rectifying subfamily J member 15", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 15 isoform b; ATP-sensitive inward rectifier potassium channel 15; inward rectifier K+ channel Kir4.2; potassium channel, inwardly rectifying subfamily J member 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:16516); (R-MMU-1296041); (R-MMU-997272)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10906485;21750661;33811157;34205849;37909221;9882736", "class_list": "", "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:9882736). The inward rectification is mainly due to the blockage of outward current by internal magnesium., [UniProtKB, PubMed]; Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the Prevalence of Morphologically Abnormal Spermatozoa. Publication Status: Online-Only, [RefSeq, PubMed]; Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na[+] Channel (ENaC)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JK34", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005267 potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0006813 potassium ion transport;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88932-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZD5-1", "uniprot_id": "IF3M_MOUSE", "mass": 31739.0, "length": 276, "protein_name": "Translation initiation factor IF-3, mitochondrial", "gene_name": "Mtif3", "organism": "Mouse", "refseq_name": "translation initiation factor IF-3, mitochondrial", "refseq_ac": "NP_001243029", "gene_names_uniprotkb": "Mtif3", "gene_names_refseq": "2810012L14Rik; Mtif3", "protein_names_uniprotkb": "Translation initiation factor IF-3, mitochondrial; IF-3(Mt); IF-3Mt; IF3(mt); IF3mt", "protein_names_refseq": "IF-3(Mt); IF-3Mt; IF3(mt); IF3mt; translation initiation factor IF-3, mitochondrial", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:76366)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "IF-3 binds to the 28S ribosomal subunit and shifts the equilibrium between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BP1;Q14BP2", "ec_number_list": "", "go_molecular_function": "GO:0043024 ribosomal small subunit binding;GO:0008135 translation factor activity, RNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0070124 mitochondrial translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K039-1", "uniprot_id": "K1143_MOUSE", "mass": 17479.0, "length": 155, "protein_name": "Uncharacterized protein KIAA1143 homolog", "gene_name": "1110059G10Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein KIAA1143 homolog", "refseq_ac": "NP_079695", "gene_names_uniprotkb": "1110059G10Rik", "gene_names_refseq": "1110059G10Rik", "protein_names_uniprotkb": "Uncharacterized protein KIAA1143 homolog", "protein_names_refseq": "uncharacterized protein KIAA1143 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66202)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15345747;17242355;19144319;21183079;21750661;30084848;30779550", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSR4;Q9D0W8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0045171 intercellular bridge", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K039-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88824-1", "uniprot_id": "JTB_MOUSE", "mass": 16329.0, "length": 146, "protein_name": "Protein JTB", "gene_name": "Jtb", "organism": "Mouse", "refseq_name": "protein JTB precursor", "refseq_ac": "NP_996807", "gene_names_uniprotkb": "Jtb; Gm622", "gene_names_refseq": "Gm622; Jtb", "protein_names_uniprotkb": "Protein JTB", "protein_names_refseq": "protein JTB precursor; protein JTB", "tax_id": 10090, "disease": "", "pathway": " (mmu:23922)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10321732;17369841;21750661;25605945;26495903;34428180", "class_list": "", "function": "Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity (By similarity). Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005819 spindle;GO:0016020 membrane", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0042127 regulation of cell population proliferation;GO:0045860 positive regulation of protein kinase activity;GO:0000281 mitotic cytokinesis;GO:0008637 apoptotic mitochondrial changes", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88824-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8C4-1", "uniprot_id": "IN35_MOUSE", "mass": 31876.0, "length": 286, "protein_name": "Interferon-induced 35 kDa protein homolog", "gene_name": "Ifi35", "organism": "Mouse", "refseq_name": "interferon-induced 35 kDa protein homolog", "refseq_ac": "NP_081596", "gene_names_uniprotkb": "Ifi35; Ifp35", "gene_names_refseq": "2010008K16Rik; IFP35; Ifi35; ifi-35", "protein_names_uniprotkb": "Interferon-induced 35 kDa protein homolog; IFP 35; Ifi-35", "protein_names_refseq": "IFP 35; interferon-induced 35 kDa protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70110)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;29038465;29350881;29698474;34362845;34428180;35809344;37777065", "class_list": "", "function": "Acts as a signaling pathway regulator involved in innate immune system response (PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with transcriptional regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (By similarity). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (By similarity). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (By similarity). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (By similarity)., [UniProtKB, UniProtKB, PubMed]; Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-kappaB pathways. Publication Status: Online-Only, [RefSeq, PubMed]; High Expression of Ifi35 is associated with exacerbates lung inflammation and H5N1 influenza disease. Publication Status: Online-Only, [RefSeq, PubMed]; IFP35 aggravates Staphylococcus aureus infection by promoting Nrf2-regulated ferroptosis., [RefSeq, PubMed]; IFP35 family proteins promote neuroinflammation and multiple sclerosis., [RefSeq, PubMed]; The danger signal interferon-induced protein 35 (IFP35) mediates acetaminophen-induced liver injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2E7", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0050729 positive regulation of inflammatory response;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D8C4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SZV5-1", "uniprot_id": "K0319_MOUSE", "mass": 117988.0, "length": 1081, "protein_name": "Dyslexia-associated protein KIAA0319 homolog", "gene_name": "D130043K22Rik; Kiaa0319", "organism": "Mouse", "refseq_name": "dyslexia-associated protein KIAA0319 homolog precursor", "refseq_ac": "NP_001074520", "gene_names_uniprotkb": "D130043K22Rik; Kiaa0319", "gene_names_refseq": "4930451E12Rik; D130043K22Rik; Kiaa0319", "protein_names_uniprotkb": "Dyslexia-associated protein KIAA0319 homolog", "protein_names_refseq": "dyslexia-associated protein KIAA0319 homolog precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:210108); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16600991;20173027;21183079;21750661;28334068;29045729;30084848;30899004;31599954;34428180", "class_list": "", "function": "Analyses of Kiaa0319L (AU040320) and double Kiaa0319;AU040320 knockouts (dKO) revealed no evidence for impaired cortical lamination, neuronal migration, neurogenesis or other anatomical abnormalities. However, dKO mice displayed an auditory deficit in a behavioral gap-in-noise detection task. Recordings of click-evoked auditory brainstem responses revealed suprathreshold deficits in wave III amplitude in AU040320-KO mice., [RefSeq, PubMed]; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites (By similarity)., [UniProtKB]; Study establishes KIAA0319 as a novel player in axon growth and regeneration with the ability to repress the intrinsic growth potential of axons; describes a novel regulatory mechanism operating during peripheral nervous system and central nervous system axon growth, and offers novel targets for the development of effective therapies to promote axon regeneration, [RefSeq, PubMed]; This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in a similar gene in human are associated with dyslexia. Alternatively spliced transcript variants have been identifed. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q14BF3;Q80U39", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0031901 early endosome membrane", "go_biological_process": "GO:0001764 neuron migration;GO:0010996 response to auditory stimulus;GO:2000171 negative regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q5SZV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BND4-1", "uniprot_id": "INT6L_MOUSE", "mass": 96941.0, "length": 861, "protein_name": "Integrator complex subunit 6-like", "gene_name": "Ints6l", "organism": "Mouse", "refseq_name": "integrator complex subunit 6-like isoform 2", "refseq_ac": "NP_766367", "gene_names_uniprotkb": "Ints6l; Ddx26b", "gene_names_refseq": "4930535D10Rik; 6330505F04Rik; D130066O12; Ddx26b; Ints6l", "protein_names_uniprotkb": "Integrator complex subunit 6-like; Protein DDX26B", "protein_names_refseq": "DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B; integrator complex subunit 6-like isoform 2; protein DDX26B", "tax_id": 10090, "disease": "", "pathway": " (mmu:236790)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25605945", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005813 centrosome;GO:0032039 integrator complex", "go_biological_process": "GO:0034472 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BND4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59111-1", "uniprot_id": "KCNH8_MOUSE", "mass": 123277.0, "length": 1102, "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH8", "gene_name": "Kcnh8", "organism": "Mouse", "refseq_name": "voltage-gated delayed rectifier potassium channel KCNH8", "refseq_ac": "NP_001026981", "gene_names_uniprotkb": "Kcnh8", "gene_names_refseq": "C130090D05Rik; ELK1; ELK3; ELK; Kcnh8; Kv12.1", "protein_names_uniprotkb": "Voltage-gated delayed rectifier potassium channel KCNH8; ELK channel 3; ELK3; Ether-a-go-go-like potassium channel 3; Potassium voltage-gated channel subfamily H member 8; Voltage-gated potassium channel subunit Kv12.1", "protein_names_refseq": "ELK channel 3; ether-a-go-go-like potassium channel 3; potassium voltage-gated channel, subfamily H, member 8; voltage-gated delayed rectifier potassium channel KCNH8; voltage-gated potassium channel subunit Kv12.1", "tax_id": 10090, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:211468); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19580749;21750661;25428506;34428180;37516908;40021952;40885482", "class_list": "", "function": "Kv12-encoded K+ channels drive the day-night switch in the repetitive firing rates of SCN neurons., [RefSeq, PubMed]; Our results suggest close conformational conservation between closed EAG (Kv12.1 and Kv10.2) and Shaker family channels, despite large differences in voltage sensitivity, activation rates, and activation threshold, [RefSeq, PubMed]; Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents. Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV. Shows no obvious change in the activation rate from different holding potentials. Activation is strongly dependent on the pH of the external solution., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BX82", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0043066 negative regulation of apoptotic process;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P59111-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BPT6-1", "uniprot_id": "IMP2L_MOUSE", "mass": 19601.0, "length": 175, "protein_name": "Mitochondrial inner membrane protease subunit 2", "gene_name": "Immp2l", "organism": "Mouse", "refseq_name": "mitochondrial inner membrane protease subunit 2", "refseq_ac": "NP_444352", "gene_names_uniprotkb": "Immp2l", "gene_names_refseq": "IMP2; Immp2l; Tg(HLA-A/H2-D)2Enge", "protein_names_uniprotkb": "Mitochondrial inner membrane protease subunit 2; 3.4.21.-; IMP2-like protein", "protein_names_refseq": "AAD mice; IMP2-like protein; mitochondrial inner membrane protease subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:93757)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11254443;21750661;22645316;30779550;34428180;37761857;38256063;39456903", "class_list": "", "function": "Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity)., [UniProtKB]; Immp2l Deficiency Induced Granulosa Cell Senescence Through STAT1/ATF4 Mediated UPR[mt] and STAT1/(ATF4)/HIF1alpha/BNIP3 Mediated Mitophagy: Prevented by Enocyanin. Publication Status: Online-Only, [RefSeq, PubMed]; Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTI2;Q925F6", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0009003 signal peptidase activity", "go_cellular_component": "GO:0042720 mitochondrial inner membrane peptidase complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033108 mitochondrial respiratory chain complex assembly;GO:0061300 cerebellum vasculature development;GO:0007283 spermatogenesis;GO:0008015 blood circulation;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BPT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35111-1", "uniprot_id": "KCNK3_MOUSE", "mass": 45068.0, "length": 409, "protein_name": "Potassium channel subfamily K member 3", "gene_name": "Kcnk3", "organism": "Mouse", "refseq_name": "potassium channel subfamily K member 3", "refseq_ac": "NP_034738", "gene_names_uniprotkb": "Kcnk3; Ctbak; Task1; Task", "gene_names_refseq": "Kcnk3; TASK; Task-1; cTBAK-1", "protein_names_uniprotkb": "Potassium channel subfamily K member 3; Acid-sensitive potassium channel protein TASK-1; Cardiac two pore background K(+) channel; TWIK-related acid-sensitive K(+) channel 1; Two pore K(+) channel KT3.1; Two pore potassium channel KT3.1; cTBAK-1", "protein_names_refseq": "TWIK-related acid-sensitive K(+) channel 1; acid-sensitive potassium channel protein TASK-1; cardiac two pore background K(+) channel; potassium channel subfamily K member 3; two pore K(+) channel KT3.1; two pore potassium channel KT3.1", "tax_id": 10090, "disease": "primary pulmonary hypertension (Disease Ontology:DOID:14557); status epilepticus (Disease Ontology:DOID:1824); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:16527); (R-MMU-1299316); (R-MMU-5576886)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10748056;12634929;17728447;18034154;18094244;18250325;18753386;25428506;28988768;37428352;38841840;9312005;9506712", "class_list": "", "function": "Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent Causal Cascade on Hypertension., [RefSeq, PubMed]; K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (By similarity) (PubMed:12634929, PubMed:18034154, PubMed:18250325, PubMed:28988768, PubMed:9506712). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (By similarity) (PubMed:18250325). In cerebellar granule cells, heteromeric KCNK3:KCNK9 channel may hyperpolarize the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, it may support high-frequency action potential firing and increased neuronal excitability (Probable). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex. Additionally, imparts chemosensitivity to type 1 cells in carotid bodies which respond to a decrease in arterial oxygen pressure or an increase in carbon dioxide pressure or pH to initiate adaptive changes in pulmonary ventilation (PubMed:18094244, PubMed:18753386). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (PubMed:18034154, PubMed:18250325). In brown adipocytes, mediates K(+) efflux that counteracts norepinephrine-induced membrane depolarization, limits Ca(2+) efflux and downstream cAMP and PKA signaling, ultimately attenuating lipid oxidation and adaptive thermogenesis (PubMed:28988768)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35163", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0005216 monoatomic ion channel activity;GO:0046982 protein heterodimerization activity;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling;GO:0034220 monoatomic ion transmembrane transport;GO:0071456 cellular response to hypoxia;GO:0006813 potassium ion transport;GO:1903818 positive regulation of voltage-gated potassium channel activity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35111-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88477-1", "uniprot_id": "IF2B1_MOUSE", "mass": 63451.0, "length": 577, "protein_name": "Insulin-like growth factor 2 mRNA-binding protein 1", "gene_name": "Igf2bp1", "organism": "Mouse", "refseq_name": "insulin-like growth factor 2 mRNA-binding protein 1 isoform 1", "refseq_ac": "NP_034081", "gene_names_uniprotkb": "Igf2bp1; Vickz1", "gene_names_refseq": "CRD-BP; Crdbp; D030026A21Rik; D11Moh40e; D11Moh45; IMP1; Igf2bp1; Neilsen; ZBP-1; Zbp1; mir-3063", "protein_names_uniprotkb": "Insulin-like growth factor 2 mRNA-binding protein 1; CRD-BP; Coding region determinant-binding protein; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IMP-1; VICKZ family member 1; ZBP-1; Zipcode-binding protein 1", "protein_names_refseq": "IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; VICKZ family member 1; coding region determinant binding protein; insulin-like growth factor 2 mRNA binding protein 1 dN CRDBP-2; insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP; insulin-like growth factor 2 mRNA-binding protein 1 isoform 1; insulin-like growth factor 2, binding protein 1; zipcode binding protein 1", "tax_id": 10090, "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158)", "pathway": " (mmu:140486)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10875929;11973350;12921532;15086518;15121863;15355996;1559612;16049158;17264115;19131326;21183079;21964071;22465430;23069990;23388827;33388443;34887587;38367942;38605226;38992831;8114742;8132663;9178888;9801297;9891060", "class_list": "", "function": "A Mettl16/m[6]A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells., [RefSeq, PubMed]; LncRNA SNHG5/IGF2BP1/Occludin axis regulates Nd2O3 induced blood-testis barrier disruption., [RefSeq, PubMed]; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage (PubMed:15355996, PubMed:17264115, PubMed:21964071, PubMed:22465430, PubMed:23388827). It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells (By similarity). Binds to the oncofetal H19 transcript and regulates its localization (By similarity). Binds to and stabilizes BTRC/FBW1A mRNA (By similarity). Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2 (By similarity). During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts (By similarity). Interacts with GAP43 transcript and transports it to axons. Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation (PubMed:23388827). Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binding to MYC mRNA is enhanced by m6A-modification of the CRD (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA. Binds to the neuron-specific TAU mRNA and regulates its localization. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons. During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The m6A reader IGF2BP1 attenuates the stability of RPL36 and cell proliferation to mediate benzene hematotoxicity by recognizing m6A modification., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80US9;Q8BRH1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity;GO:0048027 mRNA 5'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium", "go_biological_process": "GO:0010610 regulation of mRNA stability involved in response to stress;GO:0022013 pallium cell proliferation in forebrain;GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "O88477-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02535-1", "uniprot_id": "K1C10_MOUSE", "mass": 57770.0, "length": 570, "protein_name": "Keratin, type I cytoskeletal 10", "gene_name": "Krt10", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 10", "refseq_ac": "NP_034790", "gene_names_uniprotkb": "Krt10; Krt1-10", "gene_names_refseq": "D130054E02Rik; K10; K1C1; Krt-1.10; Krt1-10; Krt10", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 10; 56 kDa cytokeratin; CK-10; Cytokeratin-10; K10; Keratin, type I cytoskeletal 59 kDa; Keratin-10", "protein_names_refseq": "56 kDa cytokeratin; CK-10; cytokeratin-10; epidermal keratin 10; intermediate filament protein; keratin complex 1, acidic, gene 10; keratin, type I cytoskeletal 10; keratin, type I cytoskeletal 59 kDa; suprabasal cytokeratin 10", "tax_id": 10090, "disease": "epidermolytic hyperkeratosis 2B (Disease Ontology:DOID:0061208); epidermolytic hyperkeratosis 2A (Disease Ontology:DOID:0061223); epidermolytic hyperkeratosis (Disease Ontology:DOID:4603)", "pathway": " (mmu:16661); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "11408584;15385531;19627498;21183079;21750661;24129315;24751727;24940650;25428506;2581944;26495903;26603179;28011936;32152506;34428180;34887587;35820727;36583994;37453647;37507081;37828378;39627609;6188955", "class_list": "", "function": "(Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization., [UniProtKB, PubMed]; (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines., [UniProtKB, PubMed]; Plays a role in the establishment of the epidermal barrier on plantar skin. Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium., [UniProtKB, UniProtKB]; Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers primarily with the type II keratin KRT1, and also with KRT2, assembling into intermediate filament networks that support terminal differentiation, mechanical resilience, and epidermal barrier formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08731;Q8BUX3;Q8BV09;Q8BVU3;Q9CXH6;Q9JKB4", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0008092 cytoskeletal protein binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0009986 cell surface;GO:0001533 cornified envelope", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation;GO:0071277 cellular response to calcium ion;GO:0051290 protein heterotetramerization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P02535-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04351-1", "uniprot_id": "IL2_MOUSE", "mass": 19400.0, "length": 169, "protein_name": "Interleukin-2", "gene_name": "Il2", "organism": "Mouse", "refseq_name": "interleukin-2 precursor", "refseq_ac": "NP_032392", "gene_names_uniprotkb": "Il2; Il-2", "gene_names_refseq": "Il-2; Il2", "protein_names_uniprotkb": "Interleukin-2; IL-2; T-cell growth factor; TCGF", "protein_names_refseq": "T-cell growth factor; TCGF; interleukin-2 precursor", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); inflammatory bowel disease (Disease Ontology:DOID:0050589); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); atrial fibrillation (Disease Ontology:DOID:0060224); drug allergy (Disease Ontology:DOID:0060500); colorectal carcinoma (Disease Ontology:DOID:0080199); COVID-19 (Disease Ontology:DOID:0080600); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); birdshot chorioretinopathy (Disease Ontology:DOID:0111079); sensorineural hearing loss (Disease Ontology:DOID:10003); bacterial infectious disease (Disease Ontology:DOID:104); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); anogenital venereal wart (Disease Ontology:DOID:11168); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); ataxia telangiectasia (Disease Ontology:DOID:12704); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); aggressive periodontitis (Disease Ontology:DOID:1474); limited scleroderma (Disease Ontology:DOID:1577); cystitis (Disease Ontology:DOID:1679); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); viral hepatitis (Disease Ontology:DOID:1884); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); post-traumatic stress disorder (Disease Ontology:DOID:2055); Takayasu's arteritis (Disease Ontology:DOID:2508); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); brain infarction (Disease Ontology:DOID:3454); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); primary immunodeficiency disease (Disease Ontology:DOID:612); severe combined immunodeficiency (Disease Ontology:DOID:627); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); lung disease (Disease Ontology:DOID:850); bullous pemphigoid (Disease Ontology:DOID:8506); herpes zoster (Disease Ontology:DOID:8536); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); Zellweger syndrome (Disease Ontology:DOID:905); systemic lupus erythematosus (Disease Ontology:DOID:9074); pemphigus (Disease Ontology:DOID:9182); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:16183); (R-MMU-5673001); (R-MMU-9020558); (R-MMU-912526)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10779485;11526406;1420317;14614860;2578624;25992858;27018889;3003564;33689141;3918306;39394532;6240025;8262055;8319981;9814585", "class_list": "", "function": "Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:14614860, PubMed:9814585). Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 (PubMed:14614860, PubMed:27018889). This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance (PubMed:14614860). Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells (PubMed:9814585)., [UniProtKB, UniProtKB, PubMed]; Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 60, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P97945;Q791T3", "ec_number_list": "", "go_molecular_function": "GO:0031851 kappa-type opioid receptor binding;GO:0043208 glycosphingolipid binding;GO:0005125 cytokine activity;GO:0030246 carbohydrate binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005893 interleukin-2 receptor complex", "go_biological_process": "GO:0002366 leukocyte activation involved in immune response;GO:0038110 interleukin-2-mediated signaling pathway;GO:0046013 regulation of T cell homeostatic proliferation;GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0032740 positive regulation of interleukin-17 production", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P04351-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C7A0-1", "uniprot_id": "KHD1B_MOUSE", "mass": 14836.0, "length": 126, "protein_name": "KH homology domain-containing protein 1B", "gene_name": "Khdc1b", "organism": "Mouse", "refseq_name": "KH homology domain-containing protein 1B", "refseq_ac": "NP_001106658", "gene_names_uniprotkb": "Khdc1b", "gene_names_refseq": "Khdc1b; Khdc1c; Khdc1", "protein_names_uniprotkb": "KH homology domain-containing protein 1B", "protein_names_refseq": "KH homology domain containing 1B; KH homology domain containing 1; KH homology domain-containing protein 1B; oocyte-specific Khdc1; peptidase M20 domain containing 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:98582)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20668163", "class_list": "", "function": "Data suggest that KHDC1B, via its interaction with mCEPB1, may regulate translation of mRNA targets required for oocyte maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C7A0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15946-1", "uniprot_id": "K1B11_MOUSE", "mass": 28727.0, "length": 261, "protein_name": "Kallikrein 1-related peptidase b11", "gene_name": "Klk1b11", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b11 preproprotein", "refseq_ac": "NP_034770", "gene_names_uniprotkb": "Klk1b11; Klk-11; Klk11", "gene_names_refseq": "Klk11; Klk1b11; mGK-11", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b11; 3.4.21.35; Glandular kallikrein K11; Tissue kallikrein-11; mGK-11", "protein_names_refseq": "glandular kallikrein K11; kallikrein 1-related peptidase b11 preproprotein; tissue kallikrein-11", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:16613)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "3036794;3205728;3848399", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P15946-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36369-1", "uniprot_id": "K1B26_MOUSE", "mass": 28463.0, "length": 261, "protein_name": "Kallikrein 1-related peptidase b26", "gene_name": "Klk1b26", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b26 preproprotein", "refseq_ac": "NP_034774", "gene_names_uniprotkb": "Klk1b26; Klk-26; Klk26", "gene_names_refseq": "Egfbp2; Klk1b26; Klk26; PRECE-2; mGK-26; mGK26", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b26; 3.4.21.35; Glandular kallikrein K26; PRECE-2; Prorenin-converting enzyme 2; Tissue kallikrein 26; mGK-26", "protein_names_refseq": "EGF-BP type B; glandular kallikrein K26; kallikrein 1-related peptidase b26 preproprotein; kallikrein 1-related peptidase b26; kallikrein 1-related petidase b25; prorenin-converting enzyme 2; tissue kallikrein 26", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:16618)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1959648;6174512;6330081", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]; Prorenin-converting enzyme cleaves mouse REN-2 prorenin at a dibasic site to yield mature renin., [UniProtKB]; This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. The kallikrein genes are present in a large gene cluster on chromosome 7. The encoded preproprotein is proteolytically processed to generate a mature protein product. Expression of this gene in the submandibular gland is sexually dimorphic likely due to both transcriptional and post-transcriptional regulation. This gene is thought to be distinct from the Egfbp2 gene (Gene ID: 13647), with which it shares 98% identity (PMIDs: 1959648, 9685728), however, it is not clear if both genes are present in all strains of mice. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EI06;P00753;P00754", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0002035 brain renin-angiotensin system;GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P36369-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97382-1", "uniprot_id": "KCAB3_MOUSE", "mass": 27749.0, "length": 249, "protein_name": "Voltage-gated potassium channel subunit beta-3", "gene_name": "Kcnab3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Kcnab3; Kvbeta4", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-3; 1.1.1.-; K(+) channel subunit beta-3; Kv-beta-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-1296072)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8824288", "class_list": "", "function": "Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunit (PubMed:8824288). The beta-3/KCNAB3 subunit may mediate closure of potassium channels (By similarity). Enhances the expression of Kv2.2/KCNB2 alpha subunit-containing Kv channels but not Kv2.1/KCNB1 (PubMed:8824288). May display nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity (By similarity). The binding of oxidized and reduced NADP(H) cofactors may be required for the regulation of potassium channel activity (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.-", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97382-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04758-1", "uniprot_id": "IPKB_MOUSE", "mass": 9682.0, "length": 92, "protein_name": "cAMP-dependent protein kinase inhibitor beta", "gene_name": "Pkib", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pkib", "gene_names_refseq": "", "protein_names_uniprotkb": "cAMP-dependent protein kinase inhibitor beta; PKI-beta; cAMP-dependent protein kinase inhibitor, testis isoform", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "21750661;32848054;7684369;7905001", "class_list": "", "function": "Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004862 cAMP-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000480 negative regulation of cAMP-dependent protein kinase activity;GO:0032206 positive regulation of telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q04758-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q09TK9-1", "uniprot_id": "ISK8_MOUSE", "mass": 11778.0, "length": 105, "protein_name": "Serine protease inhibitor Kazal-type 8", "gene_name": "Spink8", "organism": "Mouse", "refseq_name": "serine protease inhibitor Kazal-type 8 precursor", "refseq_ac": "NP_898959", "gene_names_uniprotkb": "Spink8", "gene_names_refseq": "C630041L24Rik; Spink8", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 8", "protein_names_refseq": "serine protease inhibitor Kazal-type 8 precursor; serine protease inhibitor Kazal-type 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:78709)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16930550;21750661", "class_list": "", "function": "Probable serine protease inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q09TK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2TUM3-1", "uniprot_id": "KCNRG_MOUSE", "mass": 29417.0, "length": 264, "protein_name": "Potassium channel regulatory protein", "gene_name": "Kcnrg", "organism": "Mouse", "refseq_name": "potassium channel regulatory protein isoform 1", "refseq_ac": "NP_001034194", "gene_names_uniprotkb": "Kcnrg; Clld4", "gene_names_refseq": "Clld4; E030012H22Rik; Gm745; Kcnrg", "protein_names_uniprotkb": "Potassium channel regulatory protein; Potassium channel regulator; Protein CLLD4", "protein_names_refseq": "potassium channel regulatory protein isoform 1; potassium channel regulatory protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:328424)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RV87;B7ZWD9;Q6P8J6;Q8C6V1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0051260 protein homooligomerization;GO:1902260 negative regulation of delayed rectifier potassium channel activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TUM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3MI48-1", "uniprot_id": "JSPR1_MOUSE", "mass": 36093.0, "length": 332, "protein_name": "Junctional sarcoplasmic reticulum protein 1", "gene_name": "Jsrp1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Jsrp1; Jp45", "gene_names_refseq": "", "protein_names_uniprotkb": "Junctional sarcoplasmic reticulum protein 1; JP-45; Junctional-face membrane protein of 45 kDa homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:71912)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12871958;16423849;16638807;21183079;21750661;39927985", "class_list": "", "function": "Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S (By similarity). EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D755", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0072657 protein localization to membrane;GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3MI48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UPC7-1", "uniprot_id": "K0825_MOUSE", "mass": 145556.0, "length": 1272, "protein_name": "Uncharacterized protein KIAA0825 homolog", "gene_name": "2210408I21Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein KIAA0825 homolog isoform 2", "refseq_ac": "NP_001074822", "gene_names_uniprotkb": "2210408I21Rik", "gene_names_refseq": "2210408I21Rik", "protein_names_uniprotkb": "Uncharacterized protein KIAA0825 homolog", "protein_names_refseq": "uncharacterized protein KIAA0825 homolog isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72371)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34428180;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2V0;Q3TPR6;Q5FWD2;Q8BQF4;Q9D7T8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UPC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3URF8-1", "uniprot_id": "KCD21_MOUSE", "mass": 29623.0, "length": 260, "protein_name": "BTB/POZ domain-containing protein KCTD21", "gene_name": "Kctd21", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD21", "refseq_ac": "NP_001034128", "gene_names_uniprotkb": "Kctd21", "gene_names_refseq": "EG622320; Kctd21", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD21; KCASH2 protein; Potassium channel tetramerization domain-containing protein 21", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD21; K+ channel tetramerisation/BTB/POZ/BTB domain profile containing protein; KCASH2 protein; potassium channel tetramerization domain-containing protein 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:622320)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21472142;25428506", "class_list": "", "function": "Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042826 histone deacetylase binding;GO:0097602 cullin family protein binding", "go_cellular_component": "", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0045879 negative regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3URF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UTS8-1", "uniprot_id": "ISK13_MOUSE", "mass": 11530.0, "length": 97, "protein_name": "Serine protease inhibitor Kazal-type 13", "gene_name": "Spink13", "organism": "Mouse", "refseq_name": "serine protease inhibitor Kazal-type 13 precursor", "refseq_ac": "NP_001161895", "gene_names_uniprotkb": "Spink13; Spink5l3", "gene_names_refseq": "Gm10534; Spink13; Spink5l3", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 13; Serine protease inhibitor Kazal-type 5-like 3", "protein_names_refseq": "serine protease inhibitor Kazal-type 13 precursor; serine protease inhibitor Kazal-type 13; serine protease inhibitor Kazal-type 5-like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:100038417)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23430248;31219806", "class_list": "", "function": "May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity)., [UniProtKB]; Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:1902225 negative regulation of acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UTS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CAE3-1", "uniprot_id": "KCMB1_MOUSE", "mass": 21846.0, "length": 191, "protein_name": "Calcium-activated potassium channel subunit beta-1", "gene_name": "Kcnmb1", "organism": "Mouse", "refseq_name": "calcium-activated potassium channel subunit beta-1", "refseq_ac": "NP_112446", "gene_names_uniprotkb": "Kcnmb1", "gene_names_refseq": "BKbeta1; Kcnmb1", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit beta-1; BK channel subunit beta-1; BKbeta1; BKbeta; Calcium-activated potassium channel subunit beta; Calcium-activated potassium channel, subfamily M subunit beta-1; Charybdotoxin receptor subunit beta-1; K(VCA)beta-1; Maxi K channel subunit beta-1; Slo-beta-1; Slo-beta", "protein_names_refseq": "BK channel beta subunit; BK channel subunit beta-1; BKbeta; calcium-activated potassium channel subunit beta-1; calcium-activated potassium channel subunit beta; calcium-activated potassium channel, subfamily M subunit beta-1; charybdotoxin receptor subunit beta-1; k(VCA)beta-1; maxi K channel subunit beta-1; slo-beta-1; slo-beta", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:16533); (R-MMU-1296052)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11057658;21750661;29486465;29644895;32163656;36717168;9888999", "class_list": "", "function": "Compromised PASMC beta1 function may contribute to the heightened microvascular vasoconstriction that characterizes pulmonary hypertension., [RefSeq, PubMed]; Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins., [RefSeq, PubMed]; Knockout of AKAP150 improves impaired BK channel-mediated vascular dysfunction through the Akt/GSK3beta signalling pathway in diabetes mellitus., [RefSeq, PubMed]; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Whole-cell currents density of BK channels and amplitude of spontaneous transient outward currents were significantly reduced in hypoxia vascular myocytes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35336;O35645", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0008076 voltage-gated potassium channel complex;GO:0036477 somatodendritic compartment", "go_biological_process": "GO:0051592 response to calcium ion;GO:0042311 vasodilation;GO:0071361 cellular response to ethanol;GO:1901381 positive regulation of potassium ion transmembrane transport;GO:0005513 detection of calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CAE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60976-1", "uniprot_id": "JERKY_MOUSE", "mass": 62478.0, "length": 557, "protein_name": "Jerky protein", "gene_name": "Jrk", "organism": "Mouse", "refseq_name": "jerky protein", "refseq_ac": "NP_032441", "gene_names_uniprotkb": "Jrk", "gene_names_refseq": "Jrk", "protein_names_uniprotkb": "Jerky protein", "protein_names_refseq": "jerky protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:16469)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12773553;15506925;7550318", "class_list": "", "function": "JRK protein associates with a specific chromosomal centromeric locus in the cell cycle G(2) phase., [RefSeq, PubMed]; Jerky has a role in epilepsy and consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs, [RefSeq, PubMed]; May bind DNA., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q60976-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64339-1", "uniprot_id": "ISG15_MOUSE", "mass": 17898.0, "length": 161, "protein_name": "Ubiquitin-like protein ISG15", "gene_name": "Isg15", "organism": "Mouse", "refseq_name": "ubiquitin-like protein ISG15", "refseq_ac": "NP_056598", "gene_names_uniprotkb": "Isg15; G1p2; Ucrp", "gene_names_refseq": "100038882; G1p2; IGI15; IP17; Irfp; Isg15; UCRP", "protein_names_uniprotkb": "Ubiquitin-like protein ISG15; IP17; Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; Ubiquitin cross-reactive protein", "protein_names_refseq": "interferon, alpha-inducible protein; interferon-induced 15 kDa protein; interferon-induced 15-KDa protein; interferon-induced 17 kDa protein; interferon-stimulated protein (15 kDa); interferon-stimulated protein 15; ubiquitin cross-reactive protein; ubiquitin-like protein ISG15", "tax_id": 10090, "disease": "immunodeficiency 38 (Disease Ontology:DOID:0111934)", "pathway": " (mmu:100038882); (R-MMU-1169408); (R-MMU-5656169); (R-MMU-9833482); (R-MMU-9909505)", "pathway_count": 5, "publication_count": 23, "publication_id_list": "11788588;11854279;11859133;12208842;12582176;12963022;16254333;17222803;17227866;17289916;18057259;18606809;20946978;22022510;22028657;22645316;22859821;22872234;25428506;30084848;31219806;32726803;34428180", "class_list": "", "function": "Lipopolysaccharide activation of expression via interferon regulatory factor 3, [RefSeq, PubMed]; UBP43 (USP18) specifically removes ISG15 from conjugated proteins, [RefSeq, PubMed]; UBP43 plays a critical role in maintaining the homeostatic balance of ISG15-conjugated protein, and that regulation of cellular levels of ISG15 protein modification is essential for brain cell function., [RefSeq, PubMed]; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, TRIM25, STAT5A, MAPK1/ERK2 and globin. Isgylation of the viral sensor IFIH1/MDA5 promotes IFIH1/MDA5 oligomerization and triggers activation of innate immunity against a range of viruses, including coronaviruses, flaviviruses and picornaviruses. Can also isgylate: RIGI which inhibits its function in antiviral signaling response, IRF3 which inhibits its ubiquitination and degradation as well as EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A and B virus, sindbis virus (SV) and herpes simplex type-1 (HHV-1). Plays a significant role in the control of neonatal Chikungunya virus (CHIKV) infection by acting as a putative immunomodulator of pro-inflammatory cytokines. Protects mice against the consequences of Chikungunya virus infection by down-regulating the pathogenic cytokine response, often denoted as the cytokine storm. Plays a role in erythroid differentiation. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity. The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0H3", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:0007229 integrin-mediated signaling pathway;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q64339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FF0-1", "uniprot_id": "SANBR_MOUSE", "mass": 81996.0, "length": 718, "protein_name": "SANT and BTB domain regulator of class switch recombination", "gene_name": "Sanbr", "organism": "Mouse", "refseq_name": "SANT and BTB domain regulator of class switch recombination isoform 2", "refseq_ac": "NP_001334171", "gene_names_uniprotkb": "Sanbr; 0610010F05Rik; Kiaa1841", "gene_names_refseq": "0610010F05Rik; Kiaa1841; Sanbr; mKIAA1841", "protein_names_uniprotkb": "SANT and BTB domain regulator of class switch recombination; SANT and BTB domain regulator of CSR", "protein_names_refseq": "SANT and BTB domain regulator of class switch recombination isoform 2; SANT and BTB domain regulator of class switch recombination", "tax_id": 10090, "disease": "", "pathway": " (mmu:71675)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;31219806;33831416;34428180", "class_list": "", "function": "Negatively regulates class switch recombination or isotype switching in splenic B-cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AF87;A2AF88;A2AF89;A2AF91;A2AF92;Q3UQL0;Q6GQU5;Q6ZPH2;Q8BPK6;Q9CWA7", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0045190 isotype switching", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q68FF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P9J5-1", "uniprot_id": "KANK4_MOUSE", "mass": 110404.0, "length": 1016, "protein_name": "KN motif and ankyrin repeat domain-containing protein 4", "gene_name": "Kank4", "organism": "Mouse", "refseq_name": "KN motif and ankyrin repeat domain-containing protein 4", "refseq_ac": "NP_766460", "gene_names_uniprotkb": "Kank4; Ankrd38", "gene_names_refseq": "Ankrd38; C130031J23; Kank4", "protein_names_uniprotkb": "KN motif and ankyrin repeat domain-containing protein 4; Ankyrin repeat domain-containing protein 38", "protein_names_refseq": "KN motif and ankyrin repeat domain-containing protein 4; ankyrin repeat domain 38; ankyrin repeat domain-containing protein 38", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:242553)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21183079;30084848;33253712;35477278", "class_list": "", "function": "KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a TALIN-1-Dependent Manner., [RefSeq, PubMed]; May be involved in the control of cytoskeleton formation by regulating actin polymerization., [UniProtKB, UniProtKB]; Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BV03", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0051497 negative regulation of stress fiber assembly;GO:0030837 negative regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6P9J5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPD0-1", "uniprot_id": "INT3_MOUSE", "mass": 117938.0, "length": 1041, "protein_name": "Integrator complex subunit 3", "gene_name": "Ints3", "organism": "Mouse", "refseq_name": "integrator complex subunit 3", "refseq_ac": "NP_663515", "gene_names_uniprotkb": "Ints3", "gene_names_refseq": "Ints3; SOSS-A; int3", "protein_names_uniprotkb": "Integrator complex subunit 3; Int3; SOSS complex subunit A; SOSS-A; Sensor of single-strand DNA complex subunit A; Sensor of ssDNA subunit A", "protein_names_refseq": "SOSS complex subunit A; integrator complex subunit 3; sensor of single-strand DNA complex subunit A; sensor of ssDNA subunit A", "tax_id": 10090, "disease": "", "pathway": " (mmu:229543); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21183079;21750661;25428507;31219806;34428180;34887587", "class_list": "", "function": "Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites., [UniProtKB, UniProtKB]; Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS3 is involved in the post-termination step: INTS3 binds INTS7 in the open conformation of integrator complex and prevents the rebinding of Pol II to the integrator after termination cycle. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X0;A0A4X3;Q99LK7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0035861 site of double-strand break;GO:0032039 integrator complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TPD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQE7-1", "uniprot_id": "MACA2_MOUSE", "mass": 59404.0, "length": 519, "protein_name": "Putative tyrosine carboxypeptidase MATCAP2", "gene_name": "Matcap2", "organism": "Mouse", "refseq_name": "putative tyrosine carboxypeptidase MATCAP2 isoform a", "refseq_ac": "NP_081015", "gene_names_uniprotkb": "Matcap2; 9530077C05Rik; Kiaa0895", "gene_names_refseq": "1110003N12Rik; 9530077C05Rik; Matcap2; mKIAA0895", "protein_names_uniprotkb": "Putative tyrosine carboxypeptidase MATCAP2; 3.4.17.-", "protein_names_refseq": "putative tyrosine carboxypeptidase MATCAP2 isoform a; putative tyrosine carboxypeptidase MATCAP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68283)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17971504;21750661;35820727", "class_list": "", "function": "9530077C05Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Putative tyrosine carboxypeptidase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DU11;Q80V66;Q9CTJ2", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TQE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80U38-1", "uniprot_id": "KHNYN_MOUSE", "mass": 74565.0, "length": 671, "protein_name": "Protein KHNYN", "gene_name": "Khnyn", "organism": "Mouse", "refseq_name": "protein KHNYN", "refseq_ac": "NP_081419", "gene_names_uniprotkb": "Khnyn; Kiaa0323", "gene_names_refseq": "6330555F21; 9130227C08Rik; Khnyn; Kiaa0323; mKIAA0323", "protein_names_uniprotkb": "Protein KHNYN; KH and NYN domain-containing protein", "protein_names_refseq": "KH and NYN domain-containing protein; protein KHNYN", "tax_id": 10090, "disease": "", "pathway": " (mmu:219094)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;31599954;34428180", "class_list": "", "function": "This gene encodes a protein with a C-terminal RNA modifying domain that belongs to a family of ribonucleases typified by eukaryotic Nedd4-binding protein1 and the bacterial YacP-like nucleases (NYN). The NYN domain shares a common protein fold with two other groups of nucleases, the PilT N-terminal nuclease and FLAP nuclease superfamilies. In addition to the NYN domain, the protein encoded by this gene also contains an N-terminal K homology RNA-binding domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14B94;Q8BGJ6;Q8C082", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0004521 RNA endonuclease activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80U38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UK8-1", "uniprot_id": "INT2_MOUSE", "mass": 133515.0, "length": 1198, "protein_name": "Integrator complex subunit 2", "gene_name": "Ints2", "organism": "Mouse", "refseq_name": "integrator complex subunit 2 isoform 2", "refseq_ac": "NP_081697", "gene_names_uniprotkb": "Ints2; Kiaa1287", "gene_names_refseq": "2810417D08Rik; Ints2; mKIAA1287", "protein_names_uniprotkb": "Integrator complex subunit 2; Int2", "protein_names_refseq": "int2; integrator complex subunit 2 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:70422); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16239144;21750661;30084848;34428180;35820727;40021952", "class_list": "", "function": "Characterization of the human Integrator complex, [RefSeq, PubMed]; Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5SXZ5;Q5SXZ6;Q6PCY7;Q6ZPU6;Q8CB15;Q9CSE0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80UK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHI4-1", "uniprot_id": "KBTB3_MOUSE", "mass": 69551.0, "length": 607, "protein_name": "Kelch repeat and BTB domain-containing protein 3", "gene_name": "Kbtbd3", "organism": "Mouse", "refseq_name": "kelch repeat and BTB domain-containing protein 3", "refseq_ac": "NP_001158046", "gene_names_uniprotkb": "Kbtbd3; Bklhd3", "gene_names_refseq": "2200003A07Rik; Bklhd3; Kbtbd3", "protein_names_uniprotkb": "Kelch repeat and BTB domain-containing protein 3; BTB and kelch domain-containing protein 3", "protein_names_refseq": "BTB and kelch domain containing 3; BTB and kelch domain-containing protein 3; kelch repeat and BTB domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:69149)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNJ8", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BHI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BI36-1", "uniprot_id": "JKAMP_MOUSE", "mass": 35248.0, "length": 311, "protein_name": "JNK1/MAPK8-associated membrane protein", "gene_name": "Jkamp", "organism": "Mouse", "refseq_name": "JNK1/MAPK8-associated membrane protein isoform 2", "refseq_ac": "NP_001191996", "gene_names_uniprotkb": "Jkamp; Jamp", "gene_names_refseq": "1200003C05Rik; 2310047L11Rik; Jamp; Jkamp", "protein_names_uniprotkb": "JNK1/MAPK8-associated membrane protein; JAMP; JKAMP; JNK1-associated membrane protein; Medulloblastoma antigen MU-MB-50.4 homolog", "protein_names_refseq": "JNK1/MAPK8-associated membrane protein isoform 2; medulloblastoma antigen MU-MB-50.4 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:104771)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16166642;18784250;19269966;21750661;31945188;33579371", "class_list": "", "function": "C-Jun NH2 -Terminal Protein Kinase Phosphorylates the Nrf2-ECH Homology 6 Domain of Nuclear Factor Erythroid 2-Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen-Induced Liver Injury in Mice., [RefSeq, PubMed]; JAMP is a membrane-anchored regulator of the duration of JNK1 activity in response to diverse stress stimuli [JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein], [RefSeq, PubMed]; JAMP is an important component for coordinated clearance of misfolded proteins from the endoplasmic reticulum., [RefSeq, PubMed]; JKAMP inhibits the osteogenic capacity of adipose-derived stem cells in diabetic osteoporosis by modulating the Wnt signaling pathway through intragenic DNA methylation. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates the duration of MAPK8 activity in response to various stress stimuli (PubMed:16166642). Facilitates degradation of misfolded endoplasmic reticulum (ER) proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (PubMed:18784250)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B8JJ79;B8JJ80;Q99LT2;Q9CUZ1", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BI36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQR4-1", "uniprot_id": "KANL2_MOUSE", "mass": 54173.0, "length": 486, "protein_name": "KAT8 regulatory NSL complex subunit 2", "gene_name": "Kansl2", "organism": "Mouse", "refseq_name": "KAT8 regulatory NSL complex subunit 2 isoform b", "refseq_ac": "NP_001276366", "gene_names_uniprotkb": "Kansl2; 2310037I24Rik; Nsl2", "gene_names_refseq": "2310037I24Rik; B930009D17; Kansl2", "protein_names_uniprotkb": "KAT8 regulatory NSL complex subunit 2; NSL complex protein NSL2; Non-specific lethal 2 homolog", "protein_names_refseq": "KAT8 regulatory NSL complex subunit 2 isoform b; NSL complex protein NSL2; non-specific lethal 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69612); (R-MMU-3214847); (R-MMU-9772755)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21183079;21750661;24842875;31576060;37624894;37813994", "class_list": "", "function": "Loss of the lysine acetyltransferase MOF or its associated NSL-complex members KANSL2 or KANSL3 leads to a stochastic accumulation of nuclear abnormalities with genomic instability patterns including chromothripsis. Erratum:[Nat Cell Biol. 2023 Apr;25(4):626. doi: 10.1038/s41556-023-01106-y. PMID: 36849559], [RefSeq, PubMed]; Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (By similarity). Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac) (PubMed:37624894). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (PubMed:37624894). Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (PubMed:31576060)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJH8;Q569W7;Q5XJH6;Q8C8F3;Q8C8I6;Q8CEY3;Q99LE5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BQR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQZ8-1", "uniprot_id": "KCNS3_MOUSE", "mass": 55993.0, "length": 491, "protein_name": "Delayed-rectifier potassium channel regulatory subunit KCNS3", "gene_name": "Kcns3", "organism": "Mouse", "refseq_name": "delayed-rectifier potassium channel regulatory subunit KCNS3", "refseq_ac": "NP_001162036", "gene_names_uniprotkb": "Kcns3", "gene_names_refseq": "Kcns3", "protein_names_uniprotkb": "Delayed-rectifier potassium channel regulatory subunit KCNS3; Delayed-rectifier potassium channel subunit Kv9.3; Potassium voltage-gated channel subfamily S member 3", "protein_names_refseq": "delayed-rectifier potassium channel regulatory subunit KCNS3; delayed-rectifier potassium channel subunit Kv9.3; potassium voltage-gated channel subfamily S member 3; voltage-gated potassium channel subunit Kv9.3", "tax_id": 10090, "disease": "", "pathway": " (mmu:238076); (R-MMU-1296072); (R-MMU-381676)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "33940180", "class_list": "", "function": "Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia., [RefSeq, PubMed]; Potassium channel regulatory subunit that modulates the delayed rectifier potassium channel activity of KCNB1 by namely slowing down the deactivation and inactivation time constants. While it does not form functional channel on its own, it can form functional heterotetrameric channels with KCNB1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BQZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BW96-1", "uniprot_id": "KCC1D_MOUSE", "mass": 42919.0, "length": 385, "protein_name": "Calcium/calmodulin-dependent protein kinase type 1D", "gene_name": "Camk1d", "organism": "Mouse", "refseq_name": "calcium/calmodulin-dependent protein kinase type 1D isoform b", "refseq_ac": "NP_001277303", "gene_names_uniprotkb": "Camk1d", "gene_names_refseq": "A630059D12Rik; CKLiK; CaMKIdelta; Camk1d; E030025C11Rik; mCKLiK", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type 1D; 2.7.11.17; CKLiK; CaM kinase I delta; CaM kinase ID; CaM-KI delta; CaMKI delta; CaMKI-like protein kinase; mCKLiK", "protein_names_refseq": "caM kinase I delta; caM kinase ID; caM-KI delta; caMKI delta; calcium/calmodulin-dependent protein kinase 1D; calcium/calmodulin-dependent protein kinase type 1D isoform b; calcium/calmodulin-dependent protein kinase type 1D; camKI-like protein kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:227541)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;12897189;14980499;16324104;18400360;20173027;20484733;21952136;22645316;25428506;25428507;25605945;25994484;26740625;27802388;28011936;30084848;30779550;31071303;32433887;32848054;33417706;34428180;35820727;40885482", "class_list": "", "function": "Biochemical characterization of four splice variants of mouse Ca2+/calmodulin-dependent protein kinase Idelta., [RefSeq, PubMed]; CKLiK is up-regulated by the PU.1 transcription factor in murine erythroleukemia cells and is involved in apoptosis of these cells., [RefSeq, PubMed]; CaMK1d is activated through CaMKK-independent phosphorylation at serine(296)., [RefSeq, PubMed]; CaMKIdelta is involved in nuclear functions through its nuclear translocation in response to stimuli that trigger intracellular Ca2+ influx--Ca2+/calmodulin-dependent protein kinase Idelta., [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta (By similarity). Isoform 1 but not isoform 2 activates CREB1., [UniProtKB, PubMed, PubMed]; Data suggest that, under cell signaling conditions in which Camk1a is significantly dephosphorylated by phosphoprotein phosphatase activity, little Camk1d dephosphorylated is observed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3U450;Q80W64;Q8BWI7", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071622 regulation of granulocyte chemotaxis;GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q8BW96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZN2-1", "uniprot_id": "KCNV1_MOUSE", "mass": 56669.0, "length": 503, "protein_name": "Potassium voltage-gated channel subfamily V member 1", "gene_name": "Kcnv1", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily V member 1", "refseq_ac": "NP_080476", "gene_names_uniprotkb": "Kcnv1", "gene_names_refseq": "2700023A03Rik; Kcnv1; vibe", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily V member 1; Voltage-gated potassium channel subunit Kv8.1", "protein_names_refseq": "neuronal potassium channel alpha subunit; potassium channel Kv8.1 homolog; potassium voltage-gated channel subfamily V member 1; voltage-gated potassium channel subunit Kv8.1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67498); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK61;Q8BYS7;Q9CZR1", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005267 potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045171 intercellular bridge;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BZN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4P0-1", "uniprot_id": "K1958_MOUSE", "mass": 79148.0, "length": 716, "protein_name": "Uncharacterized protein KIAA1958 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein KIAA1958 homolog isoform 2", "refseq_ac": "NP_001015681", "gene_names_uniprotkb": "", "gene_names_refseq": "E130308A19Rik", "protein_names_uniprotkb": "Uncharacterized protein KIAA1958 homolog", "protein_names_refseq": "uncharacterized protein KIAA1958 homolog isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:230259)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AX79;Q8BN62;Q8K1X8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C4P0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C753-1", "uniprot_id": "KATIP_MOUSE", "mass": 179609.0, "length": 1610, "protein_name": "Katanin-interacting protein", "gene_name": "Katnip", "organism": "Mouse", "refseq_name": "katanin-interacting protein isoform 1", "refseq_ac": "NP_001074491", "gene_names_uniprotkb": "Katnip; D430042O09Rik; Kiaa0556", "gene_names_refseq": "D430042O09Rik; Katnip; Kiaa0556", "protein_names_uniprotkb": "Katanin-interacting protein", "protein_names_refseq": "katanin-interacting protein isoform 1", "tax_id": 10090, "disease": "Joubert syndrome 26 (Disease Ontology:DOID:0110995)", "pathway": " (mmu:233865)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26714646;34428180", "class_list": "", "function": "May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80TX9;Q8C759;Q8CFE1;Q8K0N9", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0005930 axoneme", "go_biological_process": "GO:0090660 cerebrospinal fluid circulation;GO:1905504 negative regulation of motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C753-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFS6-1", "uniprot_id": "KCNV2_MOUSE", "mass": 64461.0, "length": 562, "protein_name": "Potassium voltage-gated channel subfamily V member 2", "gene_name": "Kcnv2", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily V member 2", "refseq_ac": "NP_899002", "gene_names_uniprotkb": "Kcnv2", "gene_names_refseq": "KV11.1; Kcnv2", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily V member 2; Voltage-gated potassium channel subunit Kv8.2", "protein_names_refseq": "potassium voltage-gated channel subfamily V member 2; voltage-gated potassium channel subunit Kv8.2", "tax_id": 10090, "disease": "cone dystrophy with supernormal rod responses (Disease Ontology:DOID:0081022)", "pathway": " (mmu:240595); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17652418;18729211;19513789;21402906;23115240;24664678", "class_list": "", "function": "Data show that total Kv11.1 alpha subunit protein is more abundant in neonatal heart and is distributed throughout both adult and neonatal ventricles with greater abundance in epicardia., [RefSeq, PubMed]; Kcnv2 is a strong functional candidate for epilepsy modifier., [RefSeq, PubMed]; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity)., [UniProtKB]; Results demonstrate that altered potassium subunit function influences epilepsy susceptibility and implicate Kcnv2 as an epilepsy gene., [RefSeq, PubMed]; Two pore mutations (W467G and G478R) led to the formation of nonconducting heteromeric Kv2.1/Kv8.2 channels, [RefSeq, PubMed]; We conclude that nucleotide changes in evolutionary conserved crx binding site could impact retina-specific expression levels of Kcnv2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CFS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K485-1", "uniprot_id": "KCD11_MOUSE", "mass": 26300.0, "length": 232, "protein_name": "BTB/POZ domain-containing protein KCTD11", "gene_name": "Kctd11", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD11 isoform 2", "refseq_ac": "NP_694783", "gene_names_uniprotkb": "Kctd11; Ren", "gene_names_refseq": "Kctd11; Ren", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD11; KCASH1 protein; Potassium channel tetramerization domain-containing protein 11; RING-type E3 ubiquitin transferase subunit KCTD11", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD11 isoform 2; BTB/POZ domain-containing protein KCTD11; KCASH1 protein; RING-type E3 ubiquitin transferase KCTD11; RING-type E3 ubiquitin transferase subunit KCTD11; potassium channel tetramerization domain-containing protein 11; retinoic acid, EGF, and NGF upregulated", "tax_id": 10090, "disease": "", "pathway": " (mmu:216858)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12186855;15249678;16148242;20081843;21750661;31219806;34428180;38062245;38495002", "class_list": "", "function": "Downregulation of miR-337-3p in hypoxia/reoxygenation neuroblastoma cells increases KCTD11 expression., [RefSeq, PubMed]; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; REN is upregulated by neurogenic signals (retinoic acid, EGF, and NGF) in embryonal stem (ES) cells and neural progenitor cell lines in association with neurotypic differentiation., [RefSeq, PubMed]; REN protein enhances caspase-3 activation and antagonizes the Shh pathway suggesting that this gene may represent a restraint of Shh signaling., [RefSeq, PubMed]; Results show negative regulation of HDAC1 by a Cul3-REN E3 ubiquitin ligase complex., [RefSeq, PubMed]; SALL4 is a CRL3[REN/KCTD11] substrate that drives Sonic Hedgehog-dependent medulloblastoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0016740 transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0042127 regulation of cell population proliferation;GO:0045666 positive regulation of neuron differentiation;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K485-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1P5-1", "uniprot_id": "KCNKD_MOUSE", "mass": 44926.0, "length": 405, "protein_name": "Potassium channel subfamily K member 13", "gene_name": "Kcnk13", "organism": "Mouse", "refseq_name": "potassium channel subfamily K member 13", "refseq_ac": "NP_001157898", "gene_names_uniprotkb": "Kcnk13; Gm1570", "gene_names_refseq": "F730021E22Rik; Gm1570; Gm1685; Kcnk13", "protein_names_uniprotkb": "Potassium channel subfamily K member 13; THIK-1; Tandem pore domain halothane-inhibited potassium channel 1", "protein_names_refseq": "THIK-1; potassium channel subfamily K member 13; tandem pore domain halothane-inhibited potassium channel 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:217826); (R-MMU-1299287); (R-MMU-5576886)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "18209473;27566292;29290552;34642249;35353387;38409076", "class_list": "", "function": "Dysregulation of a potassium channel, THIK-1, targeted by caspase-8, accelerates cell shrinkage., [RefSeq, PubMed]; K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:38409076). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). Contributes most of K(+) currents at the plasma membrane of resting microglia (By similarity). Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (PubMed:29290552, PubMed:34642249). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (PubMed:29290552, PubMed:35353387, PubMed:38409076)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney., [RefSeq, PubMed]; The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:1900225 regulation of NLRP3 inflammasome complex assembly;GO:0060075 regulation of resting membrane potential;GO:0071805 potassium ion transmembrane transport;GO:1905810 regulation of excitatory synapse pruning", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R1P5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIM9-1", "uniprot_id": "IRGQ_MOUSE", "mass": 59323.0, "length": 583, "protein_name": "Immunity-related GTPase family Q protein", "gene_name": "Irgq", "organism": "Mouse", "refseq_name": "immunity-related GTPase family Q protein", "refseq_ac": "NP_694774", "gene_names_uniprotkb": "Irgq; Fksg27; Irgq1", "gene_names_refseq": "FKSG27; Irgq1; Irgq", "protein_names_uniprotkb": "Immunity-related GTPase family Q protein", "protein_names_refseq": "immunity-related GTPase family Q protein; immunity-related GTPase family, Q1", "tax_id": 10090, "disease": "", "pathway": " (mmu:210146)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "39481378;40684658", "class_list": "", "function": "Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation (By similarity). Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation (By similarity). Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response (PubMed:39481378). In contrast to other members of the family, does not show GTPase activity (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNC7", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005764 lysosome;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome", "go_biological_process": "GO:0010508 positive regulation of autophagy;GO:0061753 substrate localization to autophagosome;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VIM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91UZ5-1", "uniprot_id": "IMPA2_MOUSE", "mass": 31716.0, "length": 290, "protein_name": "Inositol monophosphatase 2", "gene_name": "Impa2", "organism": "Mouse", "refseq_name": "inositol monophosphatase 2", "refseq_ac": "NP_444491", "gene_names_uniprotkb": "Impa2", "gene_names_refseq": "2210415D20Rik; IMP 2; IMPase 2; Impa2", "protein_names_uniprotkb": "Inositol monophosphatase 2; 3.1.3.25; IMP 2; IMPase 2; Inositol-1(or 4)-monophosphatase 2; Myo-inositol monophosphatase A2", "protein_names_refseq": "inositol (myo)-1(or 4)-monophosphatase 2; inositol monophosphatase 2; myo-inositol monophosphatase A2", "tax_id": 10090, "disease": "bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:114663); (R-MMU-1855183)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11418250;17068342;25428506;31219806", "class_list": "", "function": "IMPA2 has a separate function in vivo from that of IMPA1, [RefSeq, PubMed]; Phosphatase that can use myo-inositol monophosphates, myo-inositol 1,4-diphosphate, scyllo-inositol-1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate and 2'-AMP as substrates in vitro. No physiological substrates has been described yet. Has been implicated as the pharmacological target for lithium Li(+) action in brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.94;3.1.3.25", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0008934 inositol monophosphate 1-phosphatase activity;GO:0052832 inositol monophosphate 3-phosphatase activity;GO:0052833 inositol monophosphate 4-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0007165 signal transduction;GO:0010226 response to lithium ion;GO:0006021 inositol biosynthetic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91UZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921Y2-1", "uniprot_id": "IMP3_MOUSE", "mass": 21777.0, "length": 184, "protein_name": "U3 small nucleolar ribonucleoprotein protein IMP3", "gene_name": "Imp3", "organism": "Mouse", "refseq_name": "U3 small nucleolar ribonucleoprotein IMP3", "refseq_ac": "NP_598737", "gene_names_uniprotkb": "Imp3", "gene_names_refseq": "1190002L16Rik; Imp3", "protein_names_uniprotkb": "U3 small nucleolar ribonucleoprotein protein IMP3; U3 snoRNP protein IMP3", "protein_names_refseq": "IMP3, U3 small nucleolar ribonucleoprotein, homolog; U3 small nucleolar ribonucleoprotein IMP3; U3 small nucleolar ribonucleoprotein protein IMP3; U3 snoRNP protein 3 homolog; U3 snoRNP protein IMP3", "tax_id": 10090, "disease": "", "pathway": " (mmu:102462); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23226335;28315936", "class_list": "", "function": "Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]; Imp3 as a key regulator of stem-like tumorigenic characteristics in osteosarcoma cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030515 snoRNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0030684 preribosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q921Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CX00-1", "uniprot_id": "IST1_MOUSE", "mass": 39468.0, "length": 362, "protein_name": "IST1 homolog", "gene_name": "Ist1", "organism": "Mouse", "refseq_name": "IST1 homolog isoform 1", "refseq_ac": "NP_082294", "gene_names_uniprotkb": "Ist1; Kiaa0174", "gene_names_refseq": "2400003C14Rik; CHMP8; Ist1; mKIAA0174", "protein_names_uniprotkb": "IST1 homolog; CHMP8; Charged multivesicular body protein 8", "protein_names_refseq": "IST1 homolog isoform 1; IST1 homolog; charged multivesicular body protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:71955); (R-MMU-6798695); (R-MMU-9668328)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "31219806;32152506;35820727;37828378;38348636", "class_list": "", "function": "ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (By similarity). Is required for efficient abscission during cytokinesis (By similarity). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (By similarity). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (By similarity). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (By similarity). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (By similarity)., [UniProtKB, UniProtKB]; Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80U68", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0090541 MIT domain binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0051301 cell division;GO:0045184 establishment of protein localization;GO:0008104 intracellular protein localization;GO:0045862 positive regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CX00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZM9-1", "uniprot_id": "KCMB2_MOUSE", "mass": 27120.0, "length": 235, "protein_name": "Calcium-activated potassium channel subunit beta-2", "gene_name": "Kcnmb2", "organism": "Mouse", "refseq_name": "calcium-activated potassium channel subunit beta-2", "refseq_ac": "NP_082507", "gene_names_uniprotkb": "Kcnmb2", "gene_names_refseq": "2700049B16Rik; 3110031N04Rik; Kcnmb2", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit beta-2; BK channel subunit beta-2; BKbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2", "protein_names_refseq": "BK channel subunit beta-2; BKbeta2; calcium-activated potassium channel subunit beta-2; calcium-activated potassium channel, subfamily M subunit beta-2; charybdotoxin receptor subunit beta-2; k(VCA)beta-2; maxi K channel subunit beta-2; slo-beta-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72413); (R-MMU-1296052)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25267913;28292889", "class_list": "", "function": "Compared current properties and cell firing properties of wild type and knockout in slices and found that knockout abolished inactivation, slowed action potential repolarization, and, during constant current injection, decreased firing, [RefSeq, PubMed]; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; We conclude that colonic K(+) secretion is intact or even increased in mice lacking the beta2-subunit of KCa1.1 channel complex despite no additional compensatory induction of KCa1.1 beta-subunits., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005267 potassium channel activity;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0005513 detection of calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CZM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBJ6-1", "uniprot_id": "JOS1_MOUSE", "mass": 23152.0, "length": 202, "protein_name": "Josephin-1", "gene_name": "Josd1", "organism": "Mouse", "refseq_name": "josephin-1", "refseq_ac": "NP_083068", "gene_names_uniprotkb": "Josd1", "gene_names_refseq": "1300006C06Rik; Josd1; mKIAA0063", "protein_names_uniprotkb": "Josephin-1; 3.4.19.12; Josephin domain-containing protein 1", "protein_names_refseq": "josephin domain-containing protein 1; josephin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74158); (R-MMU-5689877)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12486728;23625928", "class_list": "", "function": "Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity)., [UniProtKB]; JosD1, a membrane-associated DUB whose activity is regulated by ubiquitination, helps regulate membrane dynamics, cell motility, and endocytosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3E9", "ec_number_list": "3.4.19.12", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006897 endocytosis;GO:0016579 protein deubiquitination;GO:0061024 membrane organization;GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DBJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHP7-1", "uniprot_id": "PLGT2_MOUSE", "mass": 57985.0, "length": 502, "protein_name": "Protein O-glucosyltransferase 2", "gene_name": "Poglut2", "organism": "Mouse", "refseq_name": "protein O-glucosyltransferase 2 precursor", "refseq_ac": "NP_076134", "gene_names_uniprotkb": "Poglut2; Ep58; Kdelc1", "gene_names_refseq": "1810049A15Rik; 5730416C13Rik; EP58; Kdel1; Kdelc1; Poglut2", "protein_names_uniprotkb": "Protein O-glucosyltransferase 2; 2.4.1.-; 2.4.2.-; ER protein 58; ERp58; Endoplasmic reticulum resident protein 58; KDEL motif-containing protein 1; Protein O-xylosyltransferase POGLUT2", "protein_names_refseq": "ER protein 58; ERp58; KDEL (Lys-Asp-Glu-Leu) containing 1; KDEL containing protein 1; KDEL motif-containing protein 1; endoplasmic reticulum resident protein 58; endoplasmic reticulum-resident KDEL protein; protein O-glucosyltransferase 2 precursor; protein O-xylosyltransferase POGLUT2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72050)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11167020;21750661;30899004;31219806;34428180;38844137", "class_list": "glycogene;glycosyltransferase", "function": "Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues., [RefSeq, PubMed]; Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPU6;Q8C528;Q8R591;Q9D8P1", "ec_number_list": "2.4.2.-;2.4.1.-;2.4.1.376;2.4.2.63", "go_molecular_function": "GO:0046527 glucosyltransferase activity;GO:0035252 UDP-xylosyltransferase activity;GO:0035251 UDP-glucosyltransferase activity;GO:0140561 EGF-domain serine glucosyltransferase activity;GO:0140562 EGF-domain serine xylosyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol;GO:0012505 endomembrane system", "go_biological_process": "GO:0180059 protein O-linked glycosylation via glucose", "synthesized_glycan_count": 6710, "hit_score": 1.5, "record_id": "Q9JHP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2T1-1", "uniprot_id": "KCNK7_MOUSE", "mass": 32199.0, "length": 307, "protein_name": "Potassium channel subfamily K member 7", "gene_name": "Kcnk7", "organism": "Mouse", "refseq_name": "potassium channel subfamily K member 7 precursor", "refseq_ac": "NP_034739", "gene_names_uniprotkb": "Kcnk7; Dpkch3; Kcnk6; Kcnk8; Knot1", "gene_names_refseq": "2310014G03Rik; Kcnk6; Kcnk7; Kcnk8; Knot; Mlk3", "protein_names_uniprotkb": "Potassium channel subfamily K member 7; Double-pore K(+) channel 3; Neuromuscular two p domain potassium channel; Putative potassium channel DP3", "protein_names_refseq": "double-pore K(+) channel 3; neuromuscular two p domain potassium channel; potassium channel subfamily K member 7 precursor; putative potassium channel DP3", "tax_id": 10090, "disease": "", "pathway": " (mmu:16530); (R-MMU-1299308); (R-MMU-5576886)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10206991;18572259;21750661", "class_list": "", "function": "Data show that knockout mice (KCNK7-/-) display no difference in the minimum alveolar concentration (MAC) for the three volatile anesthetics compared to heterozygous (+/-) or wild-type (+/+). littermates., [RefSeq, PubMed]; Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXY0;Q9QYE8;Q9R1V1;Q9R242", "ec_number_list": "", "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex;GO:0016020 membrane", "go_biological_process": "GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z2T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTW3-1", "uniprot_id": "KCNE4_MOUSE", "mass": 18639.0, "length": 170, "protein_name": "Potassium voltage-gated channel subfamily E member 4", "gene_name": "Kcne4", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily E member 4", "refseq_ac": "NP_067317", "gene_names_uniprotkb": "Kcne4", "gene_names_refseq": "Kcne4; MiRP3", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily E member 4; MinK-related peptide 3; Minimum potassium ion channel-related peptide 3; Potassium channel subunit beta MiRP3", "protein_names_refseq": "minK-related peptide 3; minimum potassium ion channel-related peptide 3; potassium channel subunit beta MiRP3; potassium voltage-gated channel subfamily E member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:57814); (R-MMU-5576890); (R-MMU-5576893)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12944270;15707997;19773357;21750661;27802162;30969795;34272451;35915077", "class_list": "", "function": "Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE4 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Associates with KCNQ1/KVLTQ1 alpha subunit to inhibit potassium currents., [UniProtKB, UniProtKB]; Based upon previous studies and the present results, it is concluded that both hKCNE4 and mKCNE4 have a drastic inhibitory impact on both hKCNQ1 and mKCNQ1 currents., [RefSeq, PubMed]; Experimental data and the in silico structure suggest that the KCNE4 interaction hides a forward-trafficking motif within Kv1.3 in addition to adding a strong endoplasmic reticulum retention signature to the Kv1.3-KCNE4 complex., [RefSeq, PubMed]; Induction of potassium channel regulator KCNE4 in a submandibular lymph node metastasis model. Publication Status: Online-Only, [RefSeq, PubMed]; KCNE4 beta-subunit has a drastic inhibitory effect on currents generated by Kv1.1 and Kv1.3 potassium channels, [RefSeq, PubMed]; KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005267 potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0008076 voltage-gated potassium channel complex;GO:0016020 membrane", "go_biological_process": "GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization;GO:0086005 ventricular cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WTW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2YDW7-1", "uniprot_id": "KMT5A_MOUSE", "mass": 38845.0, "length": 349, "protein_name": "N-lysine methyltransferase KMT5A", "gene_name": "Kmt5a", "organism": "Mouse", "refseq_name": "N-lysine methyltransferase KMT5A isoform 2", "refseq_ac": "NP_001297652", "gene_names_uniprotkb": "Kmt5a; Setd8", "gene_names_refseq": "2410195B05Rik; Kmt5a; PR-SET7; PR/SET07; Setd8", "protein_names_uniprotkb": "N-lysine methyltransferase KMT5A; 2.1.1.-; 2.1.1.361; H4-K20-HMTase KMT5A; Histone-lysine N-methyltransferase KMT5A; Lysine-specific methylase 5A; PR-Set7; PR/SET domain-containing protein 07; PR/SET07; SET domain-containing protein 8", "protein_names_refseq": "H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; N-lysine methyltransferase KMT5A isoform 2; N-lysine methyltransferase KMT5A; N-lysine methyltransferase SETD8; PR/SET domain-containing protein 07; SET domain containing (lysine methyltransferase) 8; SET domain-containing protein 8; histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; lysine-specific methylase 5A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67956); (R-MMU-3214841); (R-MMU-6804760); (R-MMU-9764725)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21183079;21750661;23468428", "class_list": "", "function": "Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0J9", "ec_number_list": "2.1.1.-;2.1.1.359;2.1.1.364;2.1.1.361;2.1.1.362;2.1.1.354;2.1.1.355", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042054 histone methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity;GO:0042799 histone H4K20 methyltransferase activity;GO:0140944 histone H4K20 monomethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0005700 polytene chromosome", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2YDW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97328-1", "uniprot_id": "KHK_MOUSE", "mass": 32750.0, "length": 298, "protein_name": "Ketohexokinase", "gene_name": "Khk", "organism": "Mouse", "refseq_name": "ketohexokinase isoform 2", "refseq_ac": "NP_032465", "gene_names_uniprotkb": "Khk", "gene_names_refseq": "Khk", "protein_names_uniprotkb": "Ketohexokinase; 2.7.1.3; Hepatic fructokinase", "protein_names_refseq": "hepatic fructokinase; ketohexokinase isoform 2", "tax_id": 10090, "disease": "essential fructosuria (Disease Ontology:DOID:0111680)", "pathway": " (mmu:16548); (R-MMU-70350)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;37230214;37453647;38805243", "class_list": "glycogene", "function": "Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD., [RefSeq, PubMed]; Michaelis-like complex of mouse ketohexokinase isoform C., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91WU8", "ec_number_list": "2.7.1.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0070061 fructose binding;GO:0004454 ketohexokinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010043 response to zinc ion;GO:0032868 response to insulin;GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0009749 response to glucose;GO:0006000 fructose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P97328-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPW2-1", "uniprot_id": "KLF15_MOUSE", "mass": 44253.0, "length": 415, "protein_name": "Krueppel-like factor 15", "gene_name": "Klf15", "organism": "Mouse", "refseq_name": "Krueppel-like factor 15 isoform 1", "refseq_ac": "NP_075673", "gene_names_uniprotkb": "Klf15; Cklf", "gene_names_refseq": "1810013I09Rik; CKLF; KKLF; Klf15; hlb444", "protein_names_uniprotkb": "Krueppel-like factor 15; Cardiovascular Krueppel-like factor", "protein_names_refseq": "Krueppel-like factor 15 isoform 1; Kruppel-like factor 15; cardiovascular Krueppel-like factor; krueppel-like factor 15", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); aortic aneurysm (Disease Ontology:DOID:3627)", "pathway": " (mmu:66277)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12097321;15664998;17438289;18586263;20375365;20566642;21750661;22367544;22493483;23999430;38575112;38582447", "class_list": "", "function": "Functional role of circRNA CHRC through miR-431-5p/KLF15 signaling axis in the progression of heart failure., [RefSeq, PubMed]; KLF15 is an important regulator of GLUT4 in both adipose and muscle tissues., [RefSeq, PubMed]; KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB., [RefSeq, PubMed]; KLF15 plays an essential role in adipogenesis in 3T3-L1 cells through its regulation of PPAR gamma expression, [RefSeq, PubMed]; Transcriptional regulator that binds to the GA element of the CLCNKA promoter (By similarity). Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation (By similarity). Involved in podocyte differentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQB0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:1990859 cellular response to endothelin;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9EPW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D808-1", "uniprot_id": "KCNE2_MOUSE", "mass": 14370.0, "length": 123, "protein_name": "Potassium voltage-gated channel subfamily E member 2", "gene_name": "Kcne2", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily E member 2", "refseq_ac": "NP_598871", "gene_names_uniprotkb": "Kcne2", "gene_names_refseq": "2200002I16Rik; Kcne2; MiRP1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily E member 2; MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1", "protein_names_refseq": "minK-related peptide 1; minimum potassium ion channel related peptide 1; potassium channel subunit beta MiRP1; potassium voltage-gated channel subfamily E member 2", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); atrial fibrillation (Disease Ontology:DOID:0060224); long QT syndrome 6 (Disease Ontology:DOID:0110648); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (mmu:246133); (R-MMU-5576890); (R-MMU-5576893)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16754665;21750661;24595108;32191288;32584506", "class_list": "", "function": "Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE2 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:24595108). Associates with KCNH2/HERG alpha subunit Kv channel to form the rapidly activating component of the delayed rectifying potassium current (IKr) in heart. May associate with KCNQ2 and/or KCNQ3 alpha subunits to modulate the native M-type current (By similarity). May associate with HCN1 and HCN2 channel subunits to increase potassium current (By similarity). Forms a heterooligomer complex with KCNQ1/KVLQT1 alpha subunits which leads to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (PubMed:24595108)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion., [RefSeq, PubMed]; KCNE2 is essential for gastric acid secretion, the first genetic evidence that a member of the KCNE gene family is required for normal gastrointestinal function., [RefSeq, PubMed]; The data we present here suggest an important and specific role for Kcne2 in the highly specialized photoreceptor-bipolar cell synapse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1Z7", "ec_number_list": "", "go_molecular_function": "GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0042802 identical protein binding;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1903817 negative regulation of voltage-gated potassium channel activity;GO:0060306 regulation of membrane repolarization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D808-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKQ4-1", "uniprot_id": "IRX5_MOUSE", "mass": 50755.0, "length": 484, "protein_name": "Iroquois-class homeodomain protein IRX-5", "gene_name": "Irx5", "organism": "Mouse", "refseq_name": "iroquois-class homeodomain protein IRX-5", "refseq_ac": "NP_061296", "gene_names_uniprotkb": "Irx5; Irxb2", "gene_names_refseq": "Irx5", "protein_names_uniprotkb": "Iroquois-class homeodomain protein IRX-5; Homeodomain protein IRXB2; Iroquois homeobox protein 5", "protein_names_refseq": "homeodomain protein IRXB2; iroquois homeobox protein 5; iroquois related homeobox 5; iroquois-class homeodomain protein IRX-5", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:54352)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10704856;10822268;10926765;16182275;16239150;17875669;18322081;21750661", "class_list": "", "function": "Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina. Involved in craniofacial and gonadal development (By similarity). Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80WV4;Q9JLL5", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007601 visual perception;GO:0030182 neuron differentiation;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JKQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48545-1", "uniprot_id": "KCNJ5_MOUSE", "mass": 47669.0, "length": 419, "protein_name": "G protein-activated inward rectifier potassium channel 4", "gene_name": "Kcnj5", "organism": "Mouse", "refseq_name": "G protein-activated inward rectifier potassium channel 4 isoform 1", "refseq_ac": "NP_034735", "gene_names_uniprotkb": "Kcnj5; Girk4", "gene_names_refseq": "CIR; GIRK4; KATP-1; Kcnj5; Kir3.4", "protein_names_uniprotkb": "G protein-activated inward rectifier potassium channel 4; CIR; Cardiac inward rectifier; GIRK-4; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; KATP-1; Potassium channel, inwardly rectifying subfamily J member 5", "protein_names_refseq": "G protein-activated inward rectifier potassium channel 4 isoform 1; cardiac inward rectifier; g protein-activated inward rectifier potassium channel 4; heart KATP channel; inward rectifier K(+) channel Kir3.4; potassium channel, inwardly rectifying subfamily J member 5", "tax_id": 10090, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); long QT syndrome 13 (Disease Ontology:DOID:0110654); primary hyperaldosteronism (Disease Ontology:DOID:446)", "pathway": " (mmu:16521); (R-MMU-1296041); (R-MMU-997272)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10341034;21750661;7499385", "class_list": "", "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. This potassium channel is controlled by G proteins (By similarity). Forms a functional channel in association with KCNJ3/GIRK1 (PubMed:10341034)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97508;Q3TPX9", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization;GO:0015467 G-protein activated inward rectifier potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:1902937 inward rectifier potassium channel complex;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0008076 voltage-gated potassium channel complex;GO:0030315 T-tubule", "go_biological_process": "GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:1990573 potassium ion import across plasma membrane;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P48545-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AAX3-1", "uniprot_id": "KLH15_MOUSE", "mass": 69745.0, "length": 604, "protein_name": "Kelch-like protein 15", "gene_name": "Klhl15", "organism": "Mouse", "refseq_name": "kelch-like protein 15 isoform c", "refseq_ac": "NP_001034148", "gene_names_uniprotkb": "Klhl15", "gene_names_refseq": "6330500C13Rik; Klhl15", "protein_names_uniprotkb": "Kelch-like protein 15", "protein_names_refseq": "kelch-like protein 15 isoform c; kelch-like protein 15", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 103 (Disease Ontology:DOID:0112020)", "pathway": " (mmu:236904)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;34428180", "class_list": "", "function": "Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEP6;Q8K1Y4", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2AAX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2BDX4-1", "uniprot_id": "KCNG1_MOUSE", "mass": 58176.0, "length": 514, "protein_name": "Voltage-gated potassium channel regulatory subunit KCNG1", "gene_name": "Kcng1", "organism": "Mouse", "refseq_name": "voltage-gated potassium channel regulatory subunit KCNG1", "refseq_ac": "NP_001074603", "gene_names_uniprotkb": "Kcng1", "gene_names_refseq": "Kcng1", "protein_names_uniprotkb": "Voltage-gated potassium channel regulatory subunit KCNG1; Potassium voltage-gated channel subfamily G member 1; Voltage-gated potassium channel subunit Kv6.1", "protein_names_refseq": "orthologue of H. sapiens potassium voltage-gated channel, subfamily G, member 1 (KCNG1); voltage-gated potassium channel regulatory subunit KCNG1; voltage-gated potassium channel subunit Kv6.1", "tax_id": 10090, "disease": "", "pathway": " (mmu:241794); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Potassium channel subunit that does not form functional channels by itself., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0043266 regulation of potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2BDX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLM0-1", "uniprot_id": "KLF8_MOUSE", "mass": 38845.0, "length": 355, "protein_name": "Krueppel-like factor 8", "gene_name": "Klf8", "organism": "Mouse", "refseq_name": "Krueppel-like factor 8", "refseq_ac": "NP_776141", "gene_names_uniprotkb": "Klf8", "gene_names_refseq": "BKLF3; Klf8; ZNF74", "protein_names_uniprotkb": "Krueppel-like factor 8", "protein_names_refseq": "Krueppel-like factor 8; Kruppel-like factor 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:245671)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21518760;21750661;23285057;23716600;26071188;34428180", "class_list": "", "function": "KLF3 and KLF8 have overlapping roles in vivo and participate in the silencing of embryonic globin expression during development., [RefSeq, PubMed]; KLF8 is a key component of the transcription factor network that controls terminal differentiation during adipogenesis., [RefSeq, PubMed]; Klf8 is highly expressed in various regions of the mouse brain and in particular in the neurons, where it was localized in the cell nuclei., [RefSeq, PubMed]; PARP-1 as a novel KLF8-binding and -regulating protein and provided new insights into the mechanisms underlying the regulation of KLF8 nuclear localization, stability, and functions., [RefSeq, PubMed]; Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016235 aggresome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BLM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7P6-1", "uniprot_id": "ISCU_MOUSE", "mass": 18098.0, "length": 168, "protein_name": "Iron-sulfur cluster assembly enzyme ISCU", "gene_name": "Iscu", "organism": "Mouse", "refseq_name": "iron-sulfur cluster assembly enzyme ISCU isoform 1 precursor", "refseq_ac": "NP_079802", "gene_names_uniprotkb": "Iscu; Nifun", "gene_names_refseq": "2310020H20Rik; ISCU2; Iscu; Nifun; Nifu", "protein_names_uniprotkb": "Iron-sulfur cluster assembly enzyme ISCU; NifU-like N-terminal domain-containing protein; NifU-like protein", "protein_names_refseq": "IscU iron-sulfur cluster scaffold homolog; iron-sulfur cluster assembly enzyme ISCU isoform 1 precursor; iron-sulfur cluster assembly enzyme ISCU, mitochondrial; nifU-like N-terminal domain-containing protein", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (mmu:66383); (R-MMU-1362409); (R-MMU-9854311); (R-MMU-9865881)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "17603005;19808020;21165651;21298097;21750661;25597503;26560363", "class_list": "", "function": "Data show that complete loss of ISCU results in early embryonic death and confirm a fundamental role for ISCU in mammals., [RefSeq, PubMed]; ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 mutation. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results identify the iron-sulfur cluster assembly proteins (ISCU1/2) as direct targets for repression by the hypoxia-induced microRNA-210., [RefSeq, PubMed]; While IFN-gamma alone induced Nfs1 protein instability, LPS triggered a delayed decline of Nfs1, rather involving transcriptional events or mRNA instability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBC7;Q8K344", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0008198 ferrous iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0099128 mitochondrial [2Fe-2S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0044571 [2Fe-2S] cluster assembly;GO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone;GO:1904439 negative regulation of iron ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D7P6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCY0-1", "uniprot_id": "KEG1_MOUSE", "mass": 33723.0, "length": 295, "protein_name": "Glycine N-acyltransferase-like protein Keg1", "gene_name": "Keg1", "organism": "Mouse", "refseq_name": "glycine N-acyltransferase-like protein Keg1", "refseq_ac": "NP_083826", "gene_names_uniprotkb": "Keg1", "gene_names_refseq": "0610008P16Rik; GS4059; Keg1", "protein_names_uniprotkb": "Glycine N-acyltransferase-like protein Keg1; 2.3.1.13; Acyl-CoA:glycine N-acyltransferase protein Keg1; Kidney-expressed gene 1 protein", "protein_names_refseq": "Acyl-CoA:glycine N-acyltransferase protein Keg1; glycine N-acyltransferase-like protein Keg1; kidney-expressed gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:64697)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;23576753;23806337;35820727;37453647", "class_list": "", "function": "Acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.13;2.3.1.-;2.3.1.71", "go_molecular_function": "GO:0016410 N-acyltransferase activity;GO:0047961 glycine N-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005874 microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DCY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IFX3-1", "uniprot_id": "K1C40_MOUSE", "mass": 48928.0, "length": 439, "protein_name": "Keratin, type I cytoskeletal 40", "gene_name": "Krt40", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 40 isoform 1", "refseq_ac": "NP_001034755", "gene_names_uniprotkb": "Krt40; Ka36", "gene_names_refseq": "CK-40; K40; Krt40", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 40; CK-40; Cytokeratin-40; K40; Keratin-40; Type I hair keratin Ka36", "protein_names_refseq": "cytokeratin-40; keratin, type I cytoskeletal 40 isoform 1; keratin, type I cytoskeletal 40", "tax_id": 10090, "disease": "", "pathway": " (mmu:406221); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15085952;21750661", "class_list": "", "function": "May play a role in late hair differentiation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AUL0;Q3B7Y6", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament;GO:0005882 intermediate filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6IFX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJK1-1", "uniprot_id": "KCTD7_MOUSE", "mass": 33080.0, "length": 289, "protein_name": "BTB/POZ domain-containing protein KCTD7", "gene_name": "Kctd7", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD7", "refseq_ac": "NP_766097", "gene_names_uniprotkb": "Kctd7", "gene_names_refseq": "4932409E18; 9430010P06Rik; Kctd7", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD7", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD7", "tax_id": 10090, "disease": "progressive myoclonus epilepsy 3 (Disease Ontology:DOID:0111446)", "pathway": " (mmu:212919); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "20485683;21710140;21750661;22693283;22748208;31175897;35972048;37450587", "class_list": "", "function": "Deletion of Kctd7 induces defective patterning of the adult mouse retina vascular network, resulting in increased branching, vessel length, and lacunarity. These alterations reflect early and specific defects in vessel development, as emergence of the superficial and deep vascular layers were delayed. These defects are likely due to a role for Kctd7 in inner retina neurons., [RefSeq, PubMed]; KCTD7 expression hyperpolarizes the cell membrane and reduces the excitability of transfected neurons in patch clamp experiments., [RefSeq, PubMed]; Kctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects., [RefSeq, PubMed]; May be involved in the control of excitability of cortical neurons., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of multiple substrates, leading to either their proteasomal or lysosomal degradation, or modulating their activity through non-degradative ubiquitination (PubMed:37450587). Regulates voltage-gated potassium channels, thereby modulating hyperpolarizing potassium currents in neurons and inducing potassium-dependent membrane hyperpolarization. Also regulates the neuronal glutamine transporter SLC38A2/SAT2, influencing neurotransmitter precursor availability (By similarity). Regulates calpain activity via atypical, non-degradative ubiquitination by mediating ubiquitination of CAPN1 via 'Lys6'-, 'Lys27'-, 'Lys29'-, and 'Lys63'-linked chains, and CAPN2 via 'Lys6'-linked chains, thereby preventing calpain autolysis (By similarity). Promotes lysosomal enzyme trafficking and maintains lysosomal function by acting as an endogenous regulator of CLN5, enhancing its ubiquitination and proteasomal degradation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSZ3;Q3USA6;Q80WW8;Q8C0S7", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0060081 membrane hyperpolarization;GO:0030007 intracellular potassium ion homeostasis;GO:0032411 positive regulation of transporter activity;GO:0090461 intracellular glutamate homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BJK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VB2-1", "uniprot_id": "KCC1G_MOUSE", "mass": 53296.0, "length": 477, "protein_name": "Calcium/calmodulin-dependent protein kinase type 1G", "gene_name": "Camk1g", "organism": "Mouse", "refseq_name": "calcium/calmodulin-dependent protein kinase type 1G isoform 2", "refseq_ac": "NP_659066", "gene_names_uniprotkb": "Camk1g", "gene_names_refseq": "CLICK III; CLICK-III; CaMKIgamma; Camk1g", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type 1G; 2.7.11.17; CLICK III; CaM kinase I gamma; CaM kinase IG; CaM-KI gamma; CaMK-like CREB kinase III; CaMKI gamma; CaMKIG", "protein_names_refseq": "caM kinase I gamma; caM kinase IG; caM-KI gamma; caMK-like CREB kinase III; caMKI gamma; caMKIG; calcium/calmodulin-dependent protein kinase type 1G isoform 2; calcium/calmodulin-dependent protein kinase type 1G", "tax_id": 10090, "disease": "", "pathway": " (mmu:215303)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12637513;17553424;20729199;21750661", "class_list": "", "function": "CL3 may represent a key element in the Ca(2+)-dependent and lipid-raft-delineated switch that turns on extrinsic activity-regulated dendrite formation in developing cortical neurons., [RefSeq, PubMed]; CLICK-III/CaMKIgamma is a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK)., [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1., [UniProtKB, UniProtKB, UniProtKB]; Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0005954 calcium- and calmodulin-dependent protein kinase complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91VB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YG3-1", "uniprot_id": "KLDC1_MOUSE", "mass": 46830.0, "length": 406, "protein_name": "Kelch domain-containing protein 1", "gene_name": "Klhdc1", "organism": "Mouse", "refseq_name": "kelch domain-containing protein 1 isoform 1", "refseq_ac": "NP_839984", "gene_names_uniprotkb": "Klhdc1", "gene_names_refseq": "Klhdc1", "protein_names_uniprotkb": "Kelch domain-containing protein 1", "protein_names_refseq": "kelch domain-containing protein 1 isoform 1; kelch domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:271005)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Substrate-recognition component of a Cul5-RING (CRL5) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL5(KLHDC1) complex mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VDQ7", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031466 Cul5-RING ubiquitin ligase complex;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80YG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35367-1", "uniprot_id": "KERA_MOUSE", "mass": 40404.0, "length": 351, "protein_name": "Keratocan", "gene_name": "Kera", "organism": "Mouse", "refseq_name": "keratocan precursor", "refseq_ac": "NP_032464", "gene_names_uniprotkb": "Kera; Ktcn", "gene_names_refseq": "CNA2; KTN; Kera; SLRR2B", "protein_names_uniprotkb": "Keratocan; KTN; Keratan sulfate proteoglycan keratocan", "protein_names_refseq": "keratan sulfate proteoglycan keratocan; keratocan precursor", "tax_id": 10090, "disease": "cornea plana (Disease Ontology:DOID:0060287); keratoconus (Disease Ontology:DOID:10126); arcus senilis (Disease Ontology:DOID:11342); corneal dystrophy (Disease Ontology:DOID:2566)", "pathway": " (mmu:16545); (R-MMU-2022854); (R-MMU-2022857)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "37702214;9530631;9712886", "class_list": "glycogene", "function": "May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix., [UniProtKB]; Stromal matrix directs corneal fibroblasts to re-express keratocan after injury and transplantation., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0061303 cornea development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35367-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04071-1", "uniprot_id": "K1B16_MOUSE", "mass": 28722.0, "length": 261, "protein_name": "Kallikrein 1-related peptidase b16", "gene_name": "Klk1b16", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b16 preproprotein", "refseq_ac": "NP_032480", "gene_names_uniprotkb": "Klk1b16; Klk-16; Klk16", "gene_names_refseq": "Klk16; Klk1b16; mGk-16", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b16; 3.4.21.54; Gamma-renin, submandibular gland; Glandular kallikrein K16; mGK-16", "protein_names_refseq": "gamma-renin, submandibular gland; glandular kallikrein K16; kallikrein 1-related peptidase b16 preproprotein", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:16615)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;3036794;3288617;35820727;6337154", "class_list": "", "function": "This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04071-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04184-1", "uniprot_id": "KITH_MOUSE", "mass": 25776.0, "length": 233, "protein_name": "Thymidine kinase, cytosolic", "gene_name": "Tk1", "organism": "Mouse", "refseq_name": "thymidine kinase, cytosolic isoform 2", "refseq_ac": "NP_001258658", "gene_names_uniprotkb": "Tk1; Tk-1", "gene_names_refseq": "D530002A18Rik; Tk-1; Tk1a; Tk1b; Tk1", "protein_names_uniprotkb": "Thymidine kinase, cytosolic; 2.7.1.21", "protein_names_refseq": "thymidine kinase, cytosolic isoform 2; thymidine kinase, cytosolic", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); cervix carcinoma (Disease Ontology:DOID:2893); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:21877); (R-MMU-73614)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "1496920;1511894;1762910;25605945;27324368;3018504;3244356;34428180;37715794;7681542", "class_list": "", "function": "Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration., [UniProtKB, UniProtKB]; Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58EU0;Q8C3P8;Q921J8", "ec_number_list": "2.7.1.21;2.7.1.74;2.7.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004797 thymidine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0046105 thymidine biosynthetic process;GO:0046104 thymidine metabolic process;GO:0051289 protein homotetramerization;GO:1904860 DNA synthesis involved in mitotic DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P04184-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15066-1", "uniprot_id": "JUND_MOUSE", "mass": 34905.0, "length": 341, "protein_name": "Transcription factor JunD", "gene_name": "Jund", "organism": "Mouse", "refseq_name": "transcription factor JunD isoform JunD-FL", "refseq_ac": "NP_034722", "gene_names_uniprotkb": "Jund; Jun-d; Jund1", "gene_names_refseq": "Jund1; Jund", "protein_names_uniprotkb": "Transcription factor JunD; Transcription factor AP-1 subunit JunD", "protein_names_refseq": "Jun proto-oncogene related gene d1; Jun proto-oncogene related gene d; jun D proto-oncogene; transcription factor AP-1 subunit JunD; transcription factor JunD isoform JunD-FL; transcription factor JunD; transcription factor jun-D", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); crescentic glomerulonephritis (Disease Ontology:DOID:13139); transient cerebral ischemia (Disease Ontology:DOID:224); renal carcinoma (Disease Ontology:DOID:4451); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:16478)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12105216;17133482;19224205;20173027;2104845;21183079;2493644;2504580;27802388;30779550;34335468;34428180;36852467;9989505", "class_list": "", "function": "JunD Regulates Pancreatic beta-Cells Function by Altering Lipid Accumulation. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]., [RefSeq]; Transcription factor binding AP-1 sites (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing its transcriptional activity (By similarity)., [UniProtKB, UniProtKB]; Translation initiation from alternative AUG and non-AUG sites in human, mouse and rat., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0009409 response to cold;GO:0032496 response to lipopolysaccharide;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P15066-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15948-1", "uniprot_id": "K1B22_MOUSE", "mass": 28384.0, "length": 259, "protein_name": "Kallikrein 1-related peptidase b22", "gene_name": "Klk1b22", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b22 preproprotein", "refseq_ac": "NP_034244", "gene_names_uniprotkb": "Klk1b22; Klk-22; Klk22", "gene_names_refseq": "EGF-BP A; Egfbp-1; Egfbp1; Klk1b22; Klk22; mGk-22", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b22; 3.4.21.35; Beta-NGF-endopeptidase; EGF-BP A; Epidermal growth factor-binding protein type A; Glandular kallikrein K22; Nerve growth factor beta chain endopeptidase; Tissue kallikrein 22; mGK-22", "protein_names_refseq": "beta-NGF-endopeptidase; epidermal growth factor-binding protein type A; glandular kallikrein K22; kallikrein 1-related peptidase b22 preproprotein; nerve growth factor beta chain endopeptidase; tissue kallikrein 22", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:13646)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1639762;2012805;3036794;3322387;37358498", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]; Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism., [RefSeq, PubMed]; This gene encodes the beta subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. The encoded preproprotein undergoes proteolytic processing to generate a functional, mature peptide. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P15948-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16390-1", "uniprot_id": "KCNA3_MOUSE", "mass": 58564.0, "length": 528, "protein_name": "Potassium voltage-gated channel subfamily A member 3", "gene_name": "Kcna3", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily A member 3", "refseq_ac": "NP_032444", "gene_names_uniprotkb": "Kcna3", "gene_names_refseq": "Kca1-3; Kcna3; Kv1.3; Mk-3", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 3; MK3; Voltage-gated potassium channel subunit Kv1.3", "protein_names_refseq": "MK3; Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3); potassium voltage-gated channel subfamily A member 3; voltage-gated potassium channel subunit Kv1.3", "tax_id": 10090, "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); hypertension (Disease Ontology:DOID:10763); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:16491); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19773357;2305265;25644777;27802162;33300544;36100082;37591369", "class_list": "", "function": "Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage Inflammation Via ERK/NF-kappaB signaling pathway., [RefSeq, PubMed]; Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell proliferation through JAK2/STAT3 signaling pathway., [RefSeq, PubMed]; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KMM2", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0015271 outward rectifier potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P16390-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27814-1", "uniprot_id": "KLRBC_MOUSE", "mass": 25077.0, "length": 223, "protein_name": "Killer cell lectin-like receptor subfamily B member 1C", "gene_name": "Klrb1c", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor subfamily B member 1C isoform 1", "refseq_ac": "NP_001153376", "gene_names_uniprotkb": "Klrb1c; Ly55c; Nkrp1c", "gene_names_refseq": "CD161; Klrb1b; Klrb1c; Ly-59; Ly55c; Ly59; NK-RP1; NK1.1; NKR-P1.9; NKRP140; NKRP1; Nk-1.2; Nk-1; Nk1.2; Nk1; Nkrp1b; Nkrp1c; ly-55c", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily B member 1C; CD161 antigen-like family member C; Ly-55c; Lymphocyte antigen 55c; NK1.1; NKR-P1 40; NKR-P1.9; NKR-P1C; Natural killer cell surface protein P1-40", "protein_names_refseq": "CD161 antigen-like family member C; NKR-P1 40; NKR-P1B; killer cell lectin-like receptor subfamily A member 1C; killer cell lectin-like receptor subfamily B member 1C isoform 1; lymphocyte antigen 55 complex, locus C; lymphocyte antigen 55c; lymphocyte antigen 59; natural killer cell receptor protein NKR-P1C; natural killer cell receptor-P1; natural killer cell surface protein P1-40; natural killer cell-associated antigen 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17059)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10229823;11685472;12813047;1506685;15814704;16751398;1880421;21750661;33944981;37554327", "class_list": "glycogene", "function": "Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1(+) cell activation in mice., [RefSeq, PubMed]; Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 67, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q541U5;Q925G3", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0030101 natural killer cell activation;GO:0042269 regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P27814-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52189-1", "uniprot_id": "KCNJ4_MOUSE", "mass": 49899.0, "length": 445, "protein_name": "Inward rectifier potassium channel 4", "gene_name": "Kcnj4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Kcnj4; Irk3", "gene_names_refseq": "", "protein_names_uniprotkb": "Inward rectifier potassium channel 4; IRK-3; Inward rectifier K(+) channel Kir2.3; Potassium channel, inwardly rectifying subfamily J member 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "EAST syndrome (Disease Ontology:DOID:0060484)", "pathway": " (mmu:16520); (R-MMU-1296041); (R-MMU-1296053); (R-MMU-5576886); (R-MMU-997272)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11997254;16855024;21750661;33300544;35820727;7926018;8013643", "class_list": "", "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P52189-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83555-1", "uniprot_id": "KI3L1_MOUSE", "mass": 48618.0, "length": 432, "protein_name": "Killer cell immunoglobulin-like receptor 3DL1", "gene_name": "Kir3dl1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Kir3dl1", "gene_names_refseq": "", "protein_names_uniprotkb": "Killer cell immunoglobulin-like receptor 3DL1", "protein_names_refseq": "", "tax_id": 10090, "disease": "Polyomavirus-associated nephropathy (Disease Ontology:DOID:0040086); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); COVID-19 (Disease Ontology:DOID:0080600); human cytomegalovirus infection (Disease Ontology:DOID:0080827); dengue hemorrhagic fever (Disease Ontology:DOID:12206); malaria (Disease Ontology:DOID:12365); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); West Nile fever (Disease Ontology:DOID:2366); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); syphilis (Disease Ontology:DOID:4166); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic fatigue syndrome (Disease Ontology:DOID:8544)", "pathway": " (mmu:245616); (R-MMU-198933)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12594244;21750661", "class_list": "", "function": "Receptor on natural killer (NK) cells. Inhibits the activity of NK cells thus preventing cell lysis., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0032394 MHC class Ib receptor activity;GO:0060090 molecular adaptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0023029 MHC class Ib protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P83555-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q17ST2-1", "uniprot_id": "KCNA7_MOUSE", "mass": 53948.0, "length": 489, "protein_name": "Potassium voltage-gated channel subfamily A member 7", "gene_name": "Kcna7", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily A member 7", "refseq_ac": "NP_034726", "gene_names_uniprotkb": "Kcna7; Kcnc7", "gene_names_refseq": "Kcna7; Kv1.7", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 7; Voltage-gated potassium channel subunit Kv1.7", "protein_names_refseq": "potassium voltage gated channel, shaker related subfamily, member 7; potassium voltage-gated channel subfamily A member 7; potassium voltage-gated channel, shaker-related subfamily, member 7; voltage-gated potassium channel subunit Kv1.7", "tax_id": 10090, "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:16495); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11896454;16801386;9488722", "class_list": "", "function": "Kv1.7 channels from mouse heart muscle have two putative translation initiation start sites that generate two channel isoforms with different functional characteristics, mKv1.7L (489 aa) and a shorter mKv1.7S (457 aa)., [RefSeq, PubMed]; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channels formed by isoform 1 inactivate faster than channels formed by isoform 2., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70259", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q17ST2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q19A41-1", "uniprot_id": "KLF14_MOUSE", "mass": 35091.0, "length": 325, "protein_name": "Krueppel-like factor 14", "gene_name": "Klf14", "organism": "Mouse", "refseq_name": "Krueppel-like factor 14", "refseq_ac": "NP_001128565", "gene_names_uniprotkb": "Klf14", "gene_names_refseq": "5330411L03Rik; BTEB5; Klf14", "protein_names_uniprotkb": "Krueppel-like factor 14", "protein_names_refseq": "Krueppel-like factor 14; Kruppel-like factor 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:619665)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17480121;23317878;36584797;37389939;37551728;37938176", "class_list": "", "function": "Downregulation of Kruppel-like factor 14 accelerated cellular senescence and aging., [RefSeq, PubMed]; Hepatic Kruppel-like factor 14 regulates lipid metabolism in nonalcoholic steatohepatitis mice., [RefSeq, PubMed]; KLF14 gene is intronless, and is monoallelically expressed from the maternal allele in both human and mouse., [RefSeq, PubMed]; Kruppel-like factor 14 ameliorated obesity and related metabolic disorders by promoting adipose tissue browning., [RefSeq, PubMed]; The presence of progesterone induced the gene expression of egr-1 and also KLF14, indicating that this steroid channels the signaling pathway into a non-canonical mechanism., [RefSeq, PubMed]; Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARalpha-mediated fatty acid oxidation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1902070 positive regulation of sphingolipid mediated signaling pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q19A41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KL78-1", "uniprot_id": "KHD1C_MOUSE", "mass": 19664.0, "length": 166, "protein_name": "KH homology domain-containing protein 1C", "gene_name": "Khdc1c", "organism": "Mouse", "refseq_name": "KH homology domain-containing protein 1C", "refseq_ac": "NP_001029076", "gene_names_uniprotkb": "Khdc1c", "gene_names_refseq": "Khdc1b; Khdc1c", "protein_names_uniprotkb": "KH homology domain-containing protein 1C", "protein_names_refseq": "KH homology domain containing 1C; KH homology domain-containing protein 1C; oocyte-specific Khdc1b", "tax_id": 10090, "disease": "", "pathway": " (mmu:433278)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KL78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61500-1", "uniprot_id": "ITM2A_MOUSE", "mass": 29691.0, "length": 263, "protein_name": "Integral membrane protein 2A", "gene_name": "Itm2a", "organism": "Mouse", "refseq_name": "integral membrane protein 2A", "refseq_ac": "NP_032435", "gene_names_uniprotkb": "Itm2a; E25; Itm2", "gene_names_refseq": "Bricd2a; E25; Itm2a; Itm2", "protein_names_uniprotkb": "Integral membrane protein 2A; Protein E25", "protein_names_refseq": "integral membrane protein 2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:16431)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25605945;28011936;34440772;8702637;9892734", "class_list": "", "function": "Integral Membrane Protein 2A Is a Negative Regulator of Canonical and Non-Canonical Hedgehog Signalling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJP5;Q8K0H4;Q9CRW4", "ec_number_list": "", "go_molecular_function": "GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0042985 negative regulation of amyloid precursor protein biosynthetic process;GO:0002317 plasma cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61500-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61754-1", "uniprot_id": "K1B24_MOUSE", "mass": 28926.0, "length": 263, "protein_name": "Kallikrein 1-related peptidase b24", "gene_name": "Klk1b24", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b24 preproprotein", "refseq_ac": "NP_034773", "gene_names_uniprotkb": "Klk1b24; Klk-24; Klk24", "gene_names_refseq": "Klk1b24; Klk24; mGk-24", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b24; 3.4.21.35; Glandular kallikrein K24; Tissue kallikrein 24; mGK-24", "protein_names_refseq": "glandular kallikrein K24; kallikrein 1-related peptidase b24 preproprotein; tissue kallikrein 24", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:16617)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11082197;15985384;16286722;3036794", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]; MK24 may play a role in the degradation of extracellular matrix proteins in the interstitial area surrounding the Leydig cells of the adult mouse testis., [RefSeq, PubMed]; These results suggest that kallikrein 24 may play a role in the degradation of extracellular matrix proteins in the interstitial area surrounding the Leydig cells of the adult mouse testis., [RefSeq, PubMed]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A6H6V7;Q61755;Q9JM69", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61754-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61759-1", "uniprot_id": "K1B21_MOUSE", "mass": 28690.0, "length": 261, "protein_name": "Kallikrein 1-related peptidase b21", "gene_name": "Klk1b21", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b21 preproprotein", "refseq_ac": "NP_034772", "gene_names_uniprotkb": "Klk1b21; Klk-21; Klk21", "gene_names_refseq": "Klk1b21; Klk21; mGk-21", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b21; 3.4.21.35; Glandular kallikrein K21; Tissue kallikrein 21; mGK-21", "protein_names_refseq": "glandular kallikrein K21; kallikrein 1-related peptidase b21 preproprotein; tissue kallikrein 21", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:16616)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11082197;11606460;3036794", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Displays trypsin-like substrate specificity and shows activity towards casein, gelatin, fibronectin and IGFBP3., [UniProtKB, PubMed]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61760;Q9JM70", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61762-1", "uniprot_id": "KCNA5_MOUSE", "mass": 66580.0, "length": 602, "protein_name": "Potassium voltage-gated channel subfamily A member 5", "gene_name": "Kcna5", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily A member 5", "refseq_ac": "NP_666095", "gene_names_uniprotkb": "Kcna5", "gene_names_refseq": "Kcna5; Kv1.5", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 5; KV1-5; Voltage-gated potassium channel subunit Kv1.5", "protein_names_refseq": "KV1-5; potassium voltage-gated channel subfamily A member 5; voltage-gated potassium channel subunit Kv1.5", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); episodic ataxia type 1 (Disease Ontology:DOID:0050989); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); epilepsy (Disease Ontology:DOID:1826); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:16493); (R-MMU-1296072); (R-MMU-5576890)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11349004;29306897;30787218;33669857;8226976", "class_list": "", "function": "Inactive. Inhibits expression of isoform 1 and isoform 2., [UniProtKB, PubMed]; Intracellular uric acid could stabilize Kv1.5 proteins through phosphorylation of Akt and HSF1 leading to enhanced expression of Hsp70., [RefSeq, PubMed]; Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11349004, PubMed:8226976). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:11349004, PubMed:8226976). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (PubMed:29306897). May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1R6", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0005251 delayed rectifier potassium channel activity;GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization;GO:0015271 outward rectifier potassium channel activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential;GO:0007219 Notch signaling pathway;GO:0042391 regulation of membrane potential;GO:0051259 protein complex oligomerization;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61762-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62240-1", "uniprot_id": "KDM5D_MOUSE", "mass": 177018.0, "length": 1548, "protein_name": "Lysine-specific demethylase 5D", "gene_name": "Kdm5d", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 5D", "refseq_ac": "NP_035549", "gene_names_uniprotkb": "Kdm5d; Hya; Jarid1d; Smcy", "gene_names_refseq": "H-Y; HY; Jarid1d; Kdm5d; Smcy", "protein_names_uniprotkb": "Lysine-specific demethylase 5D; 1.14.11.67; H-Y; Histocompatibility Y antigen; Histone demethylase JARID1D; Jumonji/ARID domain-containing protein 1D; Protein SmcY; [histone H3]-trimethyl-L-lysine(4) demethylase 5D", "protein_names_refseq": "[histone H3]-trimethyl-L-lysine(4) demethylase 5D; histocompatibility Y antigen; histone demethylase JARID1D; jumonji, AT rich interactive domain 1D (Rbp2 like); jumonji/ARID domain-containing protein 1D; lysine (K)-specific demethylase 5D; lysine-specific demethylase 5D; protein SmcY; selected mouse cDNA on the Y", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); syndromic X-linked intellectual disability Claes-Jensen type (Disease Ontology:DOID:0060809); intellectual disability (Disease Ontology:DOID:1059); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:20592)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "10441747;10967031;11163198;11313378;11564786;11564792;11581168;12750407;14726386;14764701;14970182;15314541;15383580;15634879;16301625;16402405;16818754;17114426;17911583;19249121;20713889;21750661;21913724;21964607;24161680;25992863;28768725;31219806;34428180;35091435;37344599;3951555;7524912;7544442;9501216", "class_list": "", "function": "Histone demethylase KDM5D upregulation drives sex differences in colon cancer., [RefSeq, PubMed]; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3US03;Q6PCX3;Q9QVR9;Q9R040", "ec_number_list": "1.14.11.67", "go_molecular_function": "GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0050681 nuclear androgen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0001650 fibrillar center;GO:0000785 chromatin", "go_biological_process": "GO:0002457 T cell antigen processing and presentation;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0060765 regulation of androgen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q62240-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64291-1", "uniprot_id": "K1C12_MOUSE", "mass": 52464.0, "length": 487, "protein_name": "Keratin, type I cytoskeletal 12", "gene_name": "Krt12", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Krt12; Krt1-12; Krt1.12", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 12; CK-12; Cytokeratin-12; K12; Keratin-12", "protein_names_refseq": "", "tax_id": 10090, "disease": "Meesmann corneal dystrophy 1 (Disease Ontology:DOID:0080670); corneal dystrophy (Disease Ontology:DOID:2566)", "pathway": " (mmu:268482); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16431949;21750661;26758872;28011936;34428180;34887587;7508359;7523376;8977471", "class_list": "", "function": "Structural component of intermediate filaments in the corneal epithelium. Forms heteropolymers with the type II keratin KRT3, assembling into keratin intermediate filament networks that provide mechanical strength and structural integrity to the corneal epithelial layer., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A514;A2RRZ0", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament;GO:0005882 intermediate filament", "go_biological_process": "GO:0060429 epithelium development;GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium;GO:0061303 cornea development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q64291-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GQU2-1", "uniprot_id": "KLH23_MOUSE", "mass": 63840.0, "length": 558, "protein_name": "Kelch-like protein 23", "gene_name": "Klhl23", "organism": "Mouse", "refseq_name": "kelch-like protein 23", "refseq_ac": "NP_808452", "gene_names_uniprotkb": "Klhl23", "gene_names_refseq": "C130068N17Rik; Klhl23", "protein_names_uniprotkb": "Kelch-like protein 23", "protein_names_refseq": "kelch-like protein 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:277396)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AR06;Q8C840", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6GQU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GV12-1", "uniprot_id": "KDSR_MOUSE", "mass": 35956.0, "length": 332, "protein_name": "3-ketodihydrosphingosine reductase", "gene_name": "Kdsr", "organism": "Mouse", "refseq_name": "3-ketodihydrosphingosine reductase isoform 1 precursor", "refseq_ac": "NP_081810", "gene_names_uniprotkb": "Kdsr; Fvt1", "gene_names_refseq": "6330410P18Rik; 9430079B08Rik; Fvt1; Kdsr", "protein_names_uniprotkb": "3-ketodihydrosphingosine reductase; 1.1.1.102; 3-dehydrosphinganine reductase; FVT-1; Follicular variant translocation protein 1 homolog; KDS reductase", "protein_names_refseq": "3-dehydrosphinganine reductase; 3-ketodihydrosphingosine reductase isoform 1 precursor; KDS reductase; follicular lymphoma variant translocation 1; follicular variant translocation protein 1 homolog", "tax_id": 10090, "disease": "follicular lymphoma (Disease Ontology:DOID:0050873); erythrokeratodermia variabilis et progressiva 4 (Disease Ontology:DOID:0080250); thrombocytopenia (Disease Ontology:DOID:1588); liver disease (Disease Ontology:DOID:409)", "pathway": " (mmu:70750); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15328338;31219806;34428180", "class_list": "glycogene", "function": "Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis., [UniProtKB, PubMed]; FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.102", "go_molecular_function": "GO:0047560 3-dehydrosphinganine reductase activity;GO:0070402 NADPH binding", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006666 3-keto-sphinganine metabolic process;GO:0006686 sphingomyelin biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6GV12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IFX2-1", "uniprot_id": "K1C42_MOUSE", "mass": 50133.0, "length": 452, "protein_name": "Keratin, type I cytoskeletal 42", "gene_name": "Krt42", "organism": "Mouse", "refseq_name": "keratin, type I cytoskeletal 42", "refseq_ac": "NP_997648", "gene_names_uniprotkb": "Krt42; Ka22", "gene_names_refseq": "2410039E07Rik; CK-42; K17n; K42; Ka22; Krt42; ecat6", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 42; CK-42; Cytokeratin-42; K42; Keratin-17n; Keratin-42; Type I keratin Ka22", "protein_names_refseq": "cytokeratin-42; keratin 17n; keratin, type I cytoskeletal 42; predicted ortholog of type I keratin KA22; type I keratin KA22", "tax_id": 10090, "disease": "", "pathway": " (mmu:68239)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15085952;15102087;28011936;34203471;34428180;34887587;39627609", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MAW4;Q2M1G8;Q6SEK1", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6IFX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PCM1-1", "uniprot_id": "KDM3A_MOUSE", "mass": 147847.0, "length": 1323, "protein_name": "Lysine-specific demethylase 3A", "gene_name": "Kdm3a", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 3A isoform a", "refseq_ac": "NP_001033784", "gene_names_uniprotkb": "Kdm3a; Jhdm2a; Jmjd1a; Kiaa0742", "gene_names_refseq": "1700105C21Rik; C230043E16Rik; JHDM2a; Jmjd1a; Jmjd1; KDM2A; Kdm3a; TGSA; Tsga", "protein_names_uniprotkb": "Lysine-specific demethylase 3A; 1.14.11.65; JmjC domain-containing histone demethylation protein 2A; Jumonji domain-containing protein 1A; [histone H3]-dimethyl-L-lysine(9) demethylase 3A", "protein_names_refseq": "[histone H3]-dimethyl-L-lysine(9) demethylase 3A; jmjC domain-containing histone demethylation protein 2A; jumonji domain-containing protein 1A; lysine-specific demethylase 3A isoform a; lysine-specific demethylase 3A; testis specific gene A", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); colon cancer (Disease Ontology:DOID:219); Ewing sarcoma (Disease Ontology:DOID:3369); cervical cancer (Disease Ontology:DOID:4362); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:104263); (R-MMU-3214842)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "16619273;17943087;19194461;21750661;30603371;34428180;35820727;36852467;37751136", "class_list": "", "function": "Histone Demethylase KDM3 (JMJD1) in Transcriptional Regulation and Cancer Progression., [RefSeq, PubMed]; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation (By similarity). Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin (PubMed:17943087). Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; TSGA may modulate the function of ER71 and thereby affect spermatogenesis as well as embryonic development, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2MJQ6;Q3TKW8;Q3UML3;Q6ZQ57;Q8K2J6;Q8K2K4;Q8R350", "ec_number_list": "1.14.11.65;1.14.11.-;1.14.99.66", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0031490 chromatin DNA binding;GO:0050681 nuclear androgen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0046293 formaldehyde biosynthetic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6PCM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGH2-1", "uniprot_id": "JUPI2_MOUSE", "mass": 20020.0, "length": 190, "protein_name": "Jupiter microtubule associated homolog 2", "gene_name": "Jpt2", "organism": "Mouse", "refseq_name": "jupiter microtubule associated homolog 2", "refseq_ac": "NP_945175", "gene_names_uniprotkb": "Jpt2; D17Ertd441e; Hn1l", "gene_names_refseq": "2810430B18Rik; C16orf34; D17Ertd441e; Hn1l; Jpt2", "protein_names_uniprotkb": "Jupiter microtubule associated homolog 2; HN1-like protein; Hematological and neurological expressed 1-like protein", "protein_names_refseq": "HN1-like protein; hematological and neurological expressed 1-like protein; hematopoietic- and neurologic-expressed sequence 1-like; jupiter microtubule associated homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52009)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;23806337;25153642;26495903;28135057;28528544;32782141;36476988", "class_list": "", "function": "HN1L/AP-2gamma/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release. Confers NAADP-sensitivity to the two pore channels (TPCs) complex. Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0050848 regulation of calcium-mediated signaling;GO:0075509 endocytosis involved in viral entry into host cell", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6PGH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6Y4S4-1", "uniprot_id": "KISS1_MOUSE", "mass": 14117.0, "length": 130, "protein_name": "Metastasis-suppressor KiSS-1", "gene_name": "Kiss1", "organism": "Mouse", "refseq_name": "metastasis-suppressor KiSS-1 precursor", "refseq_ac": "NP_839991", "gene_names_uniprotkb": "Kiss1", "gene_names_refseq": "Kiss1; kisspeptin; metastatin", "protein_names_uniprotkb": "Metastasis-suppressor KiSS-1; Kisspeptin-1; Kisspeptin-52; Metastin45-54", "protein_names_refseq": "0610012C01Rik; Kiss1 metastasis-suppressor; kisspeptin-1; metastasis-suppressor KiSS-1 precursor; metastasis-suppressor KiSS-1; metastin", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 13 with or without anosmia (Disease Ontology:DOID:0090073); pre-eclampsia (Disease Ontology:DOID:10591); urinary bladder cancer (Disease Ontology:DOID:11054); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); invasive ductal carcinoma (Disease Ontology:DOID:3008); ovarian carcinoma (Disease Ontology:DOID:4001); trophoblastic neoplasm (Disease Ontology:DOID:4085)", "pathway": " (mmu:280287); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12359743;15157736;15217982;15375028;15486019;15665093;17563351;18434521;18483150;25147978;38346942", "class_list": "", "function": "Binds the G protein-coupled receptor KISS1R/GPR54 and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (By similarity). Binding to the receptor also activates beta-arrestin-dependent signaling resulting in ERK1/2 phosphorylation (PubMed:25147978). Activation of the receptor inhibits cell proliferation and cell migration, and is involved in the regulation of trophoblast invasion during early stages of pregnancy. Is also involved in the modulation of airway smooth muscle cells migration (By similarity). In bone tissue, activation of KISS1R by kisspeptin-10 recruits phosphatase DUSP18 and SRC to the KISS1R C-terminus through a G(q)-dependent signaling pathway. This leads to DUSP18-mediated dephosphorylation of SRC, down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (PubMed:38346942)., [UniProtKB, UniProtKB, PubMed, PubMed]; KiSS-1 mRNA is expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, [RefSeq, PubMed]; Kisspeptins are ligands for the G protein-coupled receptor KISS1R/GPR54 (By similarity). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:15217982, PubMed:15486019, PubMed:15375028, PubMed:15665093, PubMed:17563351). In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2); the subsequent rise in intracellular calcium levels results in the inhibition of inward rectifier potassium channels and activation of TRPC-like cation channels, leading to GnRH neurons depolarization and stimulation (PubMed:18434521, PubMed:18483150). In addition to this pathway, kisspeptin also triggers G(q)-independent signaling via beta-arrestin, leading to MAPK cascade activation and ERK1/ERK2 phosphorylation (PubMed:25147978). Kisspeptins are also involved in the regulation of other processes including cell growth, cell proliferation and cell migration (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Metastin/OT7T175 signaling may participate in implantation of the mammalian embryo, placenta formation, and maintenance of pregnancy, [RefSeq, PubMed]; Potent stimulatory effect of KiSS-1 on LH release, acting at central levels (likely hypothalamus) and eventually at pituitary. Novel role of KiSS-1/GPR54 system as relevant downstream element in neuroendocrine network governing LH secretion., [RefSeq, PubMed]; Receptor binding triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis by phospholipase C., [UniProtKB, UniProtKB]; The KiSS-1 system plays a role as a downstream element in the hypothalamic network triggering the onset of puberty., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149Z8;Q68Y93;Q80XF6", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity;GO:0031773 kisspeptin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0043025 neuronal cell body;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008285 negative regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0060112 generation of ovulation cycle rhythm", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6Y4S4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPU9-1", "uniprot_id": "KBP_MOUSE", "mass": 71052.0, "length": 617, "protein_name": "KIF-binding protein", "gene_name": "Kifbp", "organism": "Mouse", "refseq_name": "KIF-binding protein", "refseq_ac": "NP_082473", "gene_names_uniprotkb": "Kifbp; 2510003E04Rik; Kbp; Kiaa1279; Kif1bp", "gene_names_refseq": "0710007C18Rik; 2510003E04Rik; KBP; Kif1bp; Kifbp; mKIAA1279", "protein_names_uniprotkb": "KIF-binding protein; KIF1-binding protein", "protein_names_refseq": "KIF-binding protein; KIF1 binding protein", "tax_id": 10090, "disease": "Goldberg-Shprintzen syndrome (Disease Ontology:DOID:0060481)", "pathway": " (mmu:72320)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "16225668;20621975;21750661;21913724;22872234;25428506;26245936;27802388;30084848;30779550;31219806;34428180;37507081;37828378", "class_list": "", "function": "Activator of KIF1B plus-end-directed microtubule motor activity (By similarity). Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development (PubMed:20621975)., [UniProtKB, UniProtKB, PubMed]; Activator of KIF1B plus-end-directed microtubule motor activity. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development., [UniProtKB, UniProtKB, UniProtKB]; KBP expression is up-regulated during neuronal development in mouse cortical neurons., [RefSeq, PubMed]; KBP is a new binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a new type of kinesin interacting protein. Publication Status: Online-Only, [RefSeq, PubMed]; KIF1-binding protein interacts with KIF3A in haploid male germ cells, promoting spermatid elongation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYD0;Q5BKR5;Q7TPE0;Q80VQ5;Q8BZE2;Q8CFS7", "ec_number_list": "", "go_molecular_function": "GO:0019894 kinesin binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005856 cytoskeleton", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0001701 in utero embryonic development;GO:1990535 neuron projection maintenance;GO:0021952 central nervous system projection neuron axonogenesis;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6ZPU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XM3-1", "uniprot_id": "KCNG4_MOUSE", "mass": 57177.0, "length": 506, "protein_name": "Voltage-gated potassium channel regulatory subunit KCNG4", "gene_name": "Kcng4", "organism": "Mouse", "refseq_name": "voltage-gated potassium channel regulatory subunit KCNG4 isoform 1", "refseq_ac": "NP_080010", "gene_names_uniprotkb": "Kcng4", "gene_names_refseq": "4921535I01Rik; KV6.3; KV6.4; Kcng4", "protein_names_uniprotkb": "Voltage-gated potassium channel regulatory subunit KCNG4; Potassium voltage-gated channel subfamily G member 4; Voltage-gated potassium channel subunit Kv6.3; Voltage-gated potassium channel subunit Kv6.4", "protein_names_refseq": "voltage-gated potassium channel regulatory subunit KCNG4 isoform 1; voltage-gated potassium channel regulatory subunit KCNG4; voltage-gated potassium channel subunit Kv6.3; voltage-gated potassium channel subunit Kv6.4", "tax_id": 10090, "disease": "", "pathway": " (mmu:66733); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "27677211", "class_list": "", "function": "Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the time course of activation, deactivation and inactivation and on the voltage-dependence of activation. Potassium channel subunit that does not form functional channels by itself. Reduces the deactivation rate. Modulates the threshold for activation by shifting by approximately 20 mV in hyperpolarizing direction. Markedly changes the inactivation by shifting the voltage dependence of inactivation by approximately 40 mV in hyperpolarizing direction. Acceleratee activation and enhances the time course of activation., [UniProtKB, UniProtKB]; Targeted deletion of Kv6.4 in a transgenic mouse model causes male sterility as offspring from homozygous females were only obtained after mating with wild-type or heterozygous males. sterility of the homozygous males was caused by a severe reduction in total sperm-cell count and the absence of motile spermatozoa in the semen. spermatozoa of homozygous mice showed an abnormal morphology, with smaller head and shorter tail, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0043266 regulation of potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80XM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFT6-1", "uniprot_id": "JMJD4_MOUSE", "mass": 49152.0, "length": 427, "protein_name": "2-oxoglutarate and iron-dependent oxygenase JMJD4", "gene_name": "Jmjd4", "organism": "Mouse", "refseq_name": "2-oxoglutarate and iron-dependent oxygenase JMJD4 isoform 2", "refseq_ac": "NP_001191997", "gene_names_uniprotkb": "Jmjd4", "gene_names_refseq": "6430559I23; Jmjd4", "protein_names_uniprotkb": "2-oxoglutarate and iron-dependent oxygenase JMJD4; 1.14.11.-; JmjC domain-containing protein 4; Jumonji domain-containing protein 4; Lysyl-hydroxylase JMJD4", "protein_names_refseq": "2-oxoglutarate and iron-dependent oxygenase JMJD4 isoform 2; 2-oxoglutarate and iron-dependent oxygenase JMJD4; jmjC domain-containing protein 4; jumonji domain-containing protein 4; lysyl-hydroxylase JMJD4", "tax_id": 10090, "disease": "", "pathway": " (mmu:194952); (R-MMU-9629569)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "27147518;36333807", "class_list": "", "function": "Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1 (By similarity). Not essential for embryonic stem cell (ESC) maintenance and the embryonic and postnatal development (PubMed:27147518)., [UniProtKB, UniProtKB, PubMed]; JMJD4-demethylated RIG-I prevents hepatic steatosis and carcinogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Unexpectedly, Jmjd4-null ESCs exhibited normal colony morphology and maintained normal expression of pluripotent genes. Furthermore, Jmjd4-knockout embryos are born at a normal Mendelian ratio. Thus, JMJD4 is dispensable in murine development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQM9;Q80ZI5;Q8BPV8", "ec_number_list": "1.14.11.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0043565 sequence-specific DNA binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0106156 peptidyl-lysine 4-dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045905 positive regulation of translational termination;GO:0018126 protein hydroxylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BFT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJ66-1", "uniprot_id": "KAZD1_MOUSE", "mass": 34272.0, "length": 313, "protein_name": "Kazal-type serine protease inhibitor domain-containing protein 1", "gene_name": "Kazald1", "organism": "Mouse", "refseq_name": "kazal-type serine protease inhibitor domain-containing protein 1 isoform 1 precursor", "refseq_ac": "NP_849260", "gene_names_uniprotkb": "Kazald1; Bono1; Igfbprp10", "gene_names_refseq": "Bono1; IGFBP-rP10; Kazald1", "protein_names_uniprotkb": "Kazal-type serine protease inhibitor domain-containing protein 1; Bone and odontoblast-expressed protein 1; IGFBP-rP10; IGFBP-related protein 10; Insulin-like growth factor-binding-related protein 10; Insulin-like growth factor-binding-related protein 4", "protein_names_refseq": "IGFBP-related protein 10; Kazal-type serine protease inhibitor domain 1; bone and odontoblast-expressed protein 1; insulin-like growth factor-binding-related protein 10; insulin-like growth factor-binding-related protein 4; kazal-type serine protease inhibitor domain-containing protein 1 isoform 1 precursor; kazal-type serine protease inhibitor domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:107250)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;15261838;15555553;18757743", "class_list": "", "function": "Expression of Bono1 was detected in osteoblasts and secretory odontoblasts by in situ hybridization., [RefSeq, PubMed]; Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly., [UniProtKB, PubMed, PubMed]; These results suggest that IGFBP-rP10 is involved in the proliferation of osteoblasts during bone formation and bone regeneration., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q14BR9", "ec_number_list": "", "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005614 interstitial matrix", "go_biological_process": "GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization;GO:0001558 regulation of cell growth;GO:0009966 regulation of signal transduction;GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BJ66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZM0-1", "uniprot_id": "KLH12_MOUSE", "mass": 63246.0, "length": 568, "protein_name": "Kelch-like protein 12", "gene_name": "Klhl12", "organism": "Mouse", "refseq_name": "kelch-like protein 12 isoform 1", "refseq_ac": "NP_001298065", "gene_names_uniprotkb": "Klhl12; C3ip1", "gene_names_refseq": "C3ip1; Klhl12", "protein_names_uniprotkb": "Kelch-like protein 12; CUL3-interacting protein 1", "protein_names_refseq": "CUL3-interacting protein 1; kelch-like protein 12 isoform 1; kelch-like protein 12; kelch-like protein C3IP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:240756); (R-MMU-4641258)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18303015;20970343;34428180", "class_list": "", "function": "KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3-E3 ligase complex with substrate specificity toward the D4 receptor, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K225", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0034451 centriolar satellite;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0014029 neural crest formation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0014032 neural crest cell development;GO:0048208 COPII vesicle coating", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BZM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CE33-1", "uniprot_id": "KLH11_MOUSE", "mass": 80429.0, "length": 709, "protein_name": "Kelch-like protein 11", "gene_name": "Klhl11", "organism": "Mouse", "refseq_name": "kelch-like protein 11 precursor", "refseq_ac": "NP_766153", "gene_names_uniprotkb": "Klhl11", "gene_names_refseq": "Klhl11", "protein_names_uniprotkb": "Kelch-like protein 11", "protein_names_refseq": "kelch-like protein 11 precursor; kelch-like protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:217194); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "30084848;30779550;34428180", "class_list": "", "function": "Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDZ6;Q91VP6", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CE33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VED5-1", "uniprot_id": "K2C79_MOUSE", "mass": 57552.0, "length": 531, "protein_name": "Keratin, type II cytoskeletal 79", "gene_name": "Krt79", "organism": "Mouse", "refseq_name": "keratin, type II cytoskeletal 79", "refseq_ac": "NP_666175", "gene_names_uniprotkb": "Krt79; Kb38", "gene_names_refseq": "Krt79", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 79; CK-79; Cytokeratin-79; K79; Keratin-79; Type-II keratin Kb38", "protein_names_refseq": "CK-79; K79; cytokeratin-79; keratin, type II cytoskeletal 79; type-II keratin Kb38", "tax_id": 10090, "disease": "", "pathway": " (mmu:223917); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "24198274;25605945;34019948;34428180;34887587;35820727;36583994;39627609", "class_list": "", "function": "Migratory keratinocytes express keratin 79 and stream out of the hair germ and into the epidermis prior to lumen formation in the embryo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2E4", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VED5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XA8-1", "uniprot_id": "KLD8A_MOUSE", "mass": 38817.0, "length": 350, "protein_name": "Kelch domain-containing protein 8A", "gene_name": "Klhdc8a", "organism": "Mouse", "refseq_name": "kelch domain-containing protein 8A isoform 1", "refseq_ac": "NP_659059", "gene_names_uniprotkb": "Klhdc8a", "gene_names_refseq": "A630065K24Rik; Klhdc8a", "protein_names_uniprotkb": "Kelch domain-containing protein 8A", "protein_names_refseq": "kelch domain-containing protein 8A isoform 1; kelch domain-containing protein 8A", "tax_id": 10090, "disease": "", "pathway": " (mmu:213417)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91XA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YA2-1", "uniprot_id": "KPSH1_MOUSE", "mass": 48095.0, "length": 424, "protein_name": "Serine/threonine-protein kinase H1", "gene_name": "Pskh1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase H1", "refseq_ac": "NP_775608", "gene_names_uniprotkb": "Pskh1", "gene_names_refseq": "E130013P03Rik; Pskh1; b2b1230Clo", "protein_names_uniprotkb": "Serine/threonine-protein kinase H1; 2.7.11.1; PSK-H1; Protein serine kinase H1", "protein_names_refseq": "Mutant line 1230; PSK-H1; serine/threonine-protein kinase H1", "tax_id": 10090, "disease": "", "pathway": " (mmu:244631)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31219806;35820727;39132680", "class_list": "", "function": "Serine/threonine protein kinase that may be involved in the regulation of pre-mRNA processing. It may phosphorylate components of nuclear splice factor compartments (SFC), such as non-snRNP splicing factors containing a serine/arginine-rich domain (SR proteins). Reversible phosphorylation of SR proteins may cause their release into the nucleoplasm and change their local concentration, thereby influencing alternative splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3V3", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007507 heart development;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91YA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR58-1", "uniprot_id": "KMCP1_MOUSE", "mass": 32282.0, "length": 291, "protein_name": "Kidney mitochondrial carrier protein 1", "gene_name": "Slc25a30", "organism": "Mouse", "refseq_name": "kidney mitochondrial carrier protein 1", "refseq_ac": "NP_080508", "gene_names_uniprotkb": "Slc25a30; Kmcp1", "gene_names_refseq": "4933433D23Rik; KMCP1; Slc25a30", "protein_names_uniprotkb": "Kidney mitochondrial carrier protein 1; Solute carrier family 25 member 30", "protein_names_refseq": "VH186.2-D-J-C mu; kidney mitochondrial carrier protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67554)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15809292;21750661;25428506;30084848;31219806", "class_list": "", "function": "Antiporter that transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate. The sulfate/sulfate exchange is much higher than the phosphate/phosphate and malate/malate exchanges. The transport affinities is higher for sulfate and thiosulfate than for any other substrate. May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide. Also may mediate a very low unidirectional transport of sulfate, phosphate and (S)-malate., [UniProtKB, UniProtKB]; KMCP1 is involved in situations in which mitochondrial metabolism is increased, in particular when the cellular redox balance tends toward a pro-oxidant status, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAD0", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015698 inorganic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CR58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1R2-1", "uniprot_id": "KTI12_MOUSE", "mass": 38445.0, "length": 351, "protein_name": "Protein KTI12 homolog", "gene_name": "Kti12", "organism": "Mouse", "refseq_name": "protein KTI12 homolog", "refseq_ac": "NP_083847", "gene_names_uniprotkb": "Kti12", "gene_names_refseq": "1110001A12Rik; Kti12", "protein_names_uniprotkb": "Protein KTI12 homolog", "protein_names_refseq": "protein KTI12 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:100087)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;19131326;20173027;21183079;23806337", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UG06", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D1R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7N2-1", "uniprot_id": "KR261_MOUSE", "mass": 22448.0, "length": 215, "protein_name": "Keratin-associated protein 26-1", "gene_name": "Krtap26-1", "organism": "Mouse", "refseq_name": "keratin-associated protein 26-1", "refseq_ac": "NP_081381", "gene_names_uniprotkb": "Krtap26-1", "gene_names_refseq": "2310002B14Rik; Krtap26-1", "protein_names_uniprotkb": "Keratin-associated protein 26-1", "protein_names_refseq": "keratin-associated protein 26-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69533)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EIF2", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D7N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI59-1", "uniprot_id": "JAM2_MOUSE", "mass": 33047.0, "length": 298, "protein_name": "Junctional adhesion molecule B", "gene_name": "Jam2", "organism": "Mouse", "refseq_name": "junctional adhesion molecule B precursor", "refseq_ac": "NP_076333", "gene_names_uniprotkb": "Jam2; Vejam", "gene_names_refseq": "1110002N23Rik; 2410030G21Rik; 2410167M24Rik; JAM-2; JAM-B; Jam2; Jcam2; VE-JAM", "protein_names_uniprotkb": "Junctional adhesion molecule B; JAM-2; JAM-B; Junctional adhesion molecule 2; VE-JAM; Vascular endothelial junction-associated molecule", "protein_names_refseq": "junction adhesion molecule B; junction cell adhesion molecule 2; junctional adhesion molecule 2; junctional adhesion molecule B precursor; junctional adhesion molecule B; vascular endothelial junction-associated molecule", "tax_id": 10090, "disease": "basal ganglia calcification (Disease Ontology:DOID:0060230)", "pathway": " (mmu:67374); (R-MMU-202733); (R-MMU-216083)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10779521;11036763;12239159;12476045;12810109;15372036;16093349;16297198;19740376;21750661;21868569;24357068;25817991;25911611;27499083;30899004;32142645", "class_list": "", "function": "Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:16093349, PubMed:21868569, PubMed:24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:21868569, PubMed:24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:21868569, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:16297198, PubMed:19740376). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:19740376). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (Probable). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (PubMed:27499083). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (PubMed:25911611)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Promotes lymphocyte transendothelial migration, [RefSeq, PubMed]; Results suggest a role for junctional adhesion molecule-2 (JAM-2) in facilitating transmigration in endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A6X955;Q8C5K9;Q8CE95", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0044291 cell-cell contact zone;GO:0036477 somatodendritic compartment", "go_biological_process": "GO:0097241 hematopoietic stem cell migration to bone marrow;GO:0007162 negative regulation of cell adhesion;GO:0007286 spermatid development;GO:0098609 cell-cell adhesion;GO:0007159 leukocyte cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9JI59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JK97-1", "uniprot_id": "KCNQ4_MOUSE", "mass": 77057.0, "length": 696, "protein_name": "Potassium voltage-gated channel subfamily KQT member 4", "gene_name": "Kcnq4", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily KQT member 4 isoform 1", "refseq_ac": "NP_001074611", "gene_names_uniprotkb": "Kcnq4", "gene_names_refseq": "Kcnq4", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 4; KQT-like 4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel subunit Kv7.4", "protein_names_refseq": "KQT-like 4; potassium channel subunit alpha KvLQT4; potassium voltage-gated channel subfamily KQT member 4 isoform 1; potassium voltage-gated channel subfamily KQT member 4; voltage-gated potassium channel subunit Kv7.4", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 7 (Disease Ontology:DOID:0080462); autosomal dominant nonsyndromic deafness 2A (Disease Ontology:DOID:0110558); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); sensorineural hearing loss (Disease Ontology:DOID:10003); heart conduction disease (Disease Ontology:DOID:10273); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (mmu:60613); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10760300;11042367;12657673;16207888;36125121;36789839;37962101;38956136", "class_list": "", "function": "KCNQ channels set the resting membrane potential of inner hair cells in the isolated organ of Corti and maintain [Ca2+]i at low levels, [RefSeq, PubMed]; KCNQ4 potassium channel subunit deletion leads to exaggerated acoustic startle reflex in mice., [RefSeq, PubMed]; Natural History of KCNQ4 p.G285S Related Hearing Loss, Construction of iPSC and Mouse Model., [RefSeq, PubMed]; Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of sensory cells excitability in the cochlea. KCNQ4/Kv7.4 channel is composed of 4 pore-forming subunits assembled as tetramers. Promotes the outflow of potassium ions in the repolarization phase of action potential which plays a role in regulating membrane potential of excitable cells. The channel conducts a slowly activating and deactivating current. Current often shows some inward rectification at positive potentials. Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+). Important for normal physiological function of inner ear such as sensory perception of sound., [UniProtKB, UniProtKB]; Primary defect leading to high-frequency loss in DFNA2 patients may be attributable to high levels of the dysfunctional Kcnq4_v3 variant in the spiral ganglion and inner hair cells in the basal hook region, [RefSeq, PubMed]; Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells. Publication Status: Online-Only, [RefSeq, PubMed]; Vestibular hair cells are more prone to damage by excessive acceleration insult in the mouse with KCNQ4 dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A7E8;Q8C9Y6", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0006813 potassium ion transport;GO:0007605 sensory perception of sound;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JK97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JM71-1", "uniprot_id": "K1B27_MOUSE", "mass": 28742.0, "length": 263, "protein_name": "Kallikrein 1-related peptidase b27", "gene_name": "Klk1b27", "organism": "Mouse", "refseq_name": "kallikrein 1-related peptidase b27 preproprotein", "refseq_ac": "NP_064664", "gene_names_uniprotkb": "Klk1b27; Klk-27; Klk27", "gene_names_refseq": "Gk27; Klk1b27; Klk21l; Klk27; mGK-27", "protein_names_uniprotkb": "Kallikrein 1-related peptidase b27; 3.4.21.-; Glandular kallikrein K27; Tissue kallikrein 27; mGK-27; mKlk27", "protein_names_refseq": "glandular kallikrein 27; glandular kallikrein K27; kallikrein 1-related peptidase b27 preproprotein; tissue kallikrein 27", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:16619)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11082197;23838579", "class_list": "", "function": "Data indicate that androgen receptor (AR) regulation on Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays., [RefSeq, PubMed]; Serine protease with chymotrypsin-like cleavage specificity. Shows activity towards casein, gelatin, IGFBP3 and fibronectin but not towards laminin or collagens I and IV. Does not hydrolyze kininogin to release Lys-bradykinin., [UniProtKB]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2RSF8", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JM71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ26-1", "uniprot_id": "KCNE5_MOUSE", "mass": 14968.0, "length": 143, "protein_name": "Potassium voltage-gated channel subfamily E regulatory beta subunit 5", "gene_name": "Kcne5", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily E regulatory beta subunit 5", "refseq_ac": "NP_067462", "gene_names_uniprotkb": "Kcne5; Kcne1l", "gene_names_refseq": "1500015C14Rik; Kcne1l; Kcne5; Mink", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily E regulatory beta subunit 5; MinK-like protein; Potassium voltage-gated channel subfamily E member 1-like protein", "protein_names_refseq": "minK-like protein; potassium voltage-gated channel subfamily E member 1-like protein; potassium voltage-gated channel subfamily E regulatory beta subunit 5; potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene", "tax_id": 10090, "disease": "", "pathway": " (mmu:66240); (R-MMU-5576890); (R-MMU-5576893)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;10493825", "class_list": "", "function": "Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:1901380 negative regulation of potassium ion transmembrane transport;GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1903765 negative regulation of potassium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QZ26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTW2-1", "uniprot_id": "KCNE3_MOUSE", "mass": 11720.0, "length": 103, "protein_name": "Potassium voltage-gated channel subfamily E member 3", "gene_name": "Kcne3", "organism": "Mouse", "refseq_name": "potassium voltage-gated channel subfamily E member 3", "refseq_ac": "NP_001177798", "gene_names_uniprotkb": "Kcne3", "gene_names_refseq": "2210017H05Rik; Kcne3; MiRP2", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily E member 3; MinK-related peptide 2; Minimum potassium ion channel-related peptide 2; Potassium channel subunit beta MiRP2", "protein_names_refseq": "minK-related peptide 2; minimum potassium ion channel-related peptide 2; potassium channel subunit beta MiRP2; potassium voltage-gated channel subfamily E member 3", "tax_id": 10090, "disease": "Brugada syndrome 6 (Disease Ontology:DOID:0110223); hypokalemic periodic paralysis (Disease Ontology:DOID:14452)", "pathway": " (mmu:57442); (R-MMU-5576890); (R-MMU-5576893)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "28356343;31754927", "class_list": "", "function": "Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE3 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNC4/Kv3.4 alpha subunit to form the subthreshold Kv channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells (By similarity). Association with KCNQ1/KCLQT1 alpha subunit may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells., [RefSeq, PubMed]; This study showed that Kcne3 deletion impairs muscle strength and flexibility in mice., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005267 potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0045121 membrane raft", "go_biological_process": "GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1903817 negative regulation of voltage-gated potassium channel activity;GO:1903765 negative regulation of potassium ion export across plasma membrane;GO:1905025 negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WTW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUT3-1", "uniprot_id": "KS6A2_MOUSE", "mass": 83157.0, "length": 733, "protein_name": "Ribosomal protein S6 kinase alpha-2", "gene_name": "Rps6ka2", "organism": "Mouse", "refseq_name": "ribosomal protein S6 kinase alpha-2", "refseq_ac": "NP_035429", "gene_names_uniprotkb": "Rps6ka2; Mapkapk1c; Rsk3", "gene_names_refseq": "90kDa; D17Wsu134e; Rps6ka-rs1; Rps6ka2; Rsk3; p90rsk; pp90rsk", "protein_names_uniprotkb": "Ribosomal protein S6 kinase alpha-2; 2.7.11.1; 90 kDa ribosomal protein S6 kinase 2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; Protein-tyrosine kinase Mpk-9; RSK-3; Ribosomal S6 kinase 3; S6K-alpha-2; p90-RSK 2; p90RSK2; pp90RSK3", "protein_names_refseq": "90 kDa ribosomal protein S6 kinase 2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; RSK-3; S6K-alpha 2; p90-RSK 2; p90RSK2; pp90RSK3; protein-tyrosine kinase Mpk-9; ribosomal S6 kinase 3; ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase, 90kD, polypeptide 2; ribosomal protein S6 kinase, polypeptide 2", "tax_id": 10090, "disease": "Coffin-Lowry syndrome (Disease Ontology:DOID:3783)", "pathway": " (mmu:20112); (R-MMU-198753); (R-MMU-199920); (R-MMU-2559582); (R-MMU-442742); (R-MMU-444257); (R-MMU-881907)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10430666;1281307;15345747;15526037;21183079;21750661;31219806;33709453;37119767", "class_list": "", "function": "Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1., [RefSeq, PubMed]; Rps6ka2 enhances iMSC chondrogenic differentiation to attenuate knee osteoarthritis through articular cartilage regeneration in mice., [RefSeq, PubMed]; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2C0", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0072687 meiotic spindle", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WUT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVJ0-1", "uniprot_id": "KCNH3_MOUSE", "mass": 118244.0, "length": 1095, "protein_name": "Voltage-gated inwardly rectifying potassium channel KCNH3", "gene_name": "Kcnh3", "organism": "Mouse", "refseq_name": "voltage-gated inwardly rectifying potassium channel KCNH3", "refseq_ac": "NP_034731", "gene_names_uniprotkb": "Kcnh3; Elk2", "gene_names_refseq": "C030044P22Rik; Elk2; Kcnh3; Kv12.2; Melk2", "protein_names_uniprotkb": "Voltage-gated inwardly rectifying potassium channel KCNH3; ELK channel 2; Ether-a-go-go-like potassium channel 2; Potassium voltage-gated channel subfamily H member 3; Voltage-gated potassium channel subunit Kv12.2; mElk2", "protein_names_refseq": "ELK channel 2; ether a go-go like; ether-a-go-go-like potassium channel 2; potassium voltage-gated channel subfamily H member 3; voltage-gated inwardly rectifying potassium channel KCNH3; voltage-gated potassium channel subunit Kv12.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16512); (R-MMU-1296072)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10191308;19623261;19808681;25428506;27224923;35820727;37516908;40885482", "class_list": "", "function": "Authors identified ligands of the TGFbeta- and IGF-family, Foxo1, Foxo3 and Kcnh3 as novel FOXG1-target genes during telencephalic development and showed that FOXG1 interferes with Foxo1 and Tgfbeta transcription., [RefSeq, PubMed]; Data suggest that only glycosylated Kv12.2 channels (Kcnh3) show proper voltage dependence and are utilized in vivo., [RefSeq, PubMed]; Kv12-encoded K+ channels drive the day-night switch in the repetitive firing rates of SCN neurons., [RefSeq, PubMed]; Pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel (PubMed:10191308, PubMed:19623261, PubMed:19808681). Charactherized by a fast rate of activation during depolarization followed by a rapid inactivation at much more depolarized value causing inward rectification due to a C-type inactivation mechanism (PubMed:10191308, PubMed:19623261). Exhibits a rapid recovery from inactivation (PubMed:10191308)., [UniProtKB, PubMed, PubMed, PubMed]; The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. An increase in cognitive function was observed when this gene was knocked out, while deletion of the gene resulted in hippocampal hyperexcitability and epilepsy. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B2RU85;E9QMZ8;Q6U1M1", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0005249 voltage-gated potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9WVJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z287-1", "uniprot_id": "KR121_MOUSE", "mass": 13119.0, "length": 130, "protein_name": "Keratin-associated protein 12-1", "gene_name": "Krtap12-1", "organism": "Mouse", "refseq_name": "keratin-associated protein 12-1", "refseq_ac": "NP_034800", "gene_names_uniprotkb": "Krtap12-1", "gene_names_refseq": "D10Jhu14e; Krtap12-1", "protein_names_uniprotkb": "Keratin-associated protein 12-1", "protein_names_refseq": "keratin-associated protein 12-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16694); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9878246", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z287-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15947-1", "uniprot_id": "KLK1_MOUSE", "mass": 28775.0, "length": 261, "protein_name": "Kallikrein-1", "gene_name": "Klk1", "organism": "Mouse", "refseq_name": "kallikrein-1 isoform 2 precursor", "refseq_ac": "NP_001307260", "gene_names_uniprotkb": "Klk1; Klk-6; Klk6", "gene_names_refseq": "0610007D04Rik; KAL-B; Kal; Klk1b6; Klk1; Klk6; mGk-6", "protein_names_uniprotkb": "Kallikrein-1; 3.4.21.35; Glandular kallikrein K1; KAL-B; Renal kallikrein; Tissue kallikrein-6; mGK-6", "protein_names_refseq": "glandular kallikrein K1; kallikrein renal/pancreas/salivary; kallikrein-1 isoform 2 precursor; tissue kallikrein-6; true tissue kallikrein", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:16612)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1639762;21750661;2583286;3007510", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein are unable to generate significant levels of kinins in most tissues, develop cardiovascular abnormalities and exhibit hypercalciuria of renal origin. This gene is located in a cluster of several related kallikrein genes on chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61855", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P15947-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08584-1", "uniprot_id": "KLF6_MOUSE", "mass": 31877.0, "length": 283, "protein_name": "Krueppel-like factor 6", "gene_name": "Klf6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Klf6; Copeb; Cpbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Krueppel-like factor 6; Core promoter element-binding protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10570007;11274234;21750661", "class_list": "", "function": "Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1905205 positive regulation of connective tissue replacement;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08584-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AJB7-1", "uniprot_id": "LCN5_MOUSE", "mass": 21013.0, "length": 192, "protein_name": "Epididymal-specific lipocalin-5", "gene_name": "Lcn5", "organism": "Mouse", "refseq_name": "epididymal-specific lipocalin-5 isoform b precursor", "refseq_ac": "NP_001036095", "gene_names_uniprotkb": "Lcn5; Mep10", "gene_names_refseq": "E-RABP; Erabp; Lcn5; MEP10", "protein_names_uniprotkb": "Epididymal-specific lipocalin-5; E-RABP; Epididymal retinoic acid-binding protein; Epididymal secretory protein 10; MEP 10; mE-RABP", "protein_names_refseq": "epididymal retinoic acid binding protein; epididymal secretory protein 10; epididymal-specific lipocalin-5 isoform b precursor; epididymal-specific lipocalin-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:13863)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14595821;1591332;1591333;16740652;2393684;9607808;9669522", "class_list": "", "function": "Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 13-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation., [UniProtKB, PubMed, PubMed]; Forkhead box A2 restricts androgen-regulated gene expression of lipocalin 5 in the mouse epididymis., [RefSeq, PubMed]; This gene encodes a small secreted protein that is expressed in the epididymis and binds retinoic acid. The precursor protein is processed into both a longer major form and a shorter minor form. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88787;Q3TS05;Q3UW42;Q9R2C6", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding;GO:0005501 retinoid binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0042573 retinoic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2AJB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2BE28-1", "uniprot_id": "LAS1L_MOUSE", "mass": 89414.0, "length": 776, "protein_name": "Ribosomal biogenesis protein LAS1L", "gene_name": "Las1l", "organism": "Mouse", "refseq_name": "ribosomal biogenesis protein LAS1L isoform 2", "refseq_ac": "NP_690035", "gene_names_uniprotkb": "Las1l", "gene_names_refseq": "1810030A06Rik; 5830482G23Rik; Las1l", "protein_names_uniprotkb": "Ribosomal biogenesis protein LAS1L; 3.1.-.-; Endoribonuclease LAS1L; Protein LAS1 homolog", "protein_names_refseq": "endoribonuclease LAS1L; protein LAS1 homolog; ribosomal biogenesis protein LAS1L isoform 2; ribosomal biogenesis protein LAS1L", "tax_id": 10090, "disease": "Wilson-Turner syndrome (Disease Ontology:DOID:0060814)", "pathway": " (mmu:76130); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;18299400;21952136;22872859;25153642;25428506;28135057;28528544;31219806;34428180;39627609", "class_list": "", "function": "Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC], [RefSeq, PubMed]; Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2BE30;Q6KAR5;Q8C742", "ec_number_list": "3.1.-.-;3.1.13.-;2.7.1.78;3.1.13.1;3.1.26.-;3.6.4.13;3.4.22.-", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0071339 MLL1 complex;GO:0090730 Las1 complex;GO:0120330 rixosome complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "A2BE28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2KG20-1", "uniprot_id": "KLRI1_MOUSE", "mass": 28642.0, "length": 248, "protein_name": "Killer cell lectin-like receptor subfamily I member 1", "gene_name": "Klri1", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor subfamily I member 1", "refseq_ac": "NP_001012538", "gene_names_uniprotkb": "Klri1", "gene_names_refseq": "Klri1", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily I member 1", "protein_names_refseq": "killer cell lectin-like receptor subfamily I member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:503550)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15650876;18713988", "class_list": "glycogene", "function": "Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates inhibition of NK cell cytolytic activity., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 56, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5DT35", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0002228 natural killer cell mediated immunity;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0002223 stimulatory C-type lectin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B2KG20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89112-1", "uniprot_id": "LANC1_MOUSE", "mass": 45341.0, "length": 399, "protein_name": "Glutathione S-transferase LANCL1", "gene_name": "Lancl1", "organism": "Mouse", "refseq_name": "glutathione S-transferase LANCL1", "refseq_ac": "NP_001177913", "gene_names_uniprotkb": "Lancl1; Gpr69a", "gene_names_refseq": "Gpr69a; Gpr69; Lancl1; p40", "protein_names_uniprotkb": "Glutathione S-transferase LANCL1; 2.5.1.18; 40 kDa erythrocyte membrane protein; LanC-like protein 1; p40", "protein_names_refseq": "40 kDa erythrocyte membrane protein; G protein-coupled receptor 69A; LanC-like protein 1; glutathione S-transferase LANCL1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14768)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11474189;14514412;17305318;21750661;22872234;25158856;31219806;34428180;37507081;9714732", "class_list": "", "function": "Functions as a glutathione transferase (PubMed:25158856). Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate (PubMed:25158856). Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (PubMed:25158856). May play a role in EPS8 signaling. Binds glutathione (By similarity)., [UniProtKB, UniProtKB, PubMed]; LanC-like protein 1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.3.99.3;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0050750 low-density lipoprotein particle receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0031179 peptide modification;GO:1990748 cellular detoxification", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O89112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54707-1", "uniprot_id": "KLRD1_MOUSE", "mass": 20808.0, "length": 179, "protein_name": "Natural killer cells antigen CD94", "gene_name": "Klrd1", "organism": "Mouse", "refseq_name": "natural killer cells antigen CD94", "refseq_ac": "NP_034784", "gene_names_uniprotkb": "Klrd1; Cd94", "gene_names_refseq": "CD94; Klrd1", "protein_names_uniprotkb": "Natural killer cells antigen CD94; Killer cell lectin-like receptor subfamily D member 1", "protein_names_refseq": "natural killer cells antigen CD94", "tax_id": 10090, "disease": "", "pathway": " (mmu:16643); (R-MMU-2172127); (R-MMU-2424491)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;25520036;30535636;9464811;9600963", "class_list": "glycogene", "function": "Data suggest that the Cd94(LocA)/NKG2A receptor (NKG2A) heterodimeric receptor is widely expressed among M. musculus subspecies musculus., [RefSeq, PubMed]; Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal., [UniProtKB, UniProtKB]; KLRD1-KLRC1 acts as an immune inhibitory receptor. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Upon MHC-E-peptide binding, transmits intracellular signals through KLRC1 immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHIP-1 and INPPL1/SHIP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules., [UniProtKB, UniProtKB]; KLRD1-KLRC2 acts as an immune activating receptor. On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation., [UniProtKB, UniProtKB]; Segregation of a spontaneous Klrd1 mutation in DBA/2 mouse substrains Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O54708", "ec_number_list": "", "go_molecular_function": "GO:0023024 MHC class I protein complex binding;GO:0030246 carbohydrate binding;GO:1990405 protein antigen binding;GO:0030108 HLA-A specific activating MHC class I receptor activity;GO:0023030 MHC class Ib protein binding, via antigen binding groove", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002228 natural killer cell mediated immunity;GO:0002250 adaptive immune response;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0001915 negative regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54707-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59280-1", "uniprot_id": "KLHL8_MOUSE", "mass": 69788.0, "length": 629, "protein_name": "Kelch-like protein 8", "gene_name": "Klhl8", "organism": "Mouse", "refseq_name": "kelch-like protein 8", "refseq_ac": "NP_848856", "gene_names_uniprotkb": "Klhl8", "gene_names_refseq": "2310001P09Rik; D5Ertd431e; Klhl8", "protein_names_uniprotkb": "Kelch-like protein 8", "protein_names_refseq": "kelch-like protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:246293)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CD84", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P59280-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31324-1", "uniprot_id": "KAP3_MOUSE", "mass": 46167.0, "length": 416, "protein_name": "cAMP-dependent protein kinase type II-beta regulatory subunit", "gene_name": "Prkar2b", "organism": "Mouse", "refseq_name": "cAMP-dependent protein kinase type II-beta regulatory subunit isoform 1", "refseq_ac": "NP_035288", "gene_names_uniprotkb": "Prkar2b", "gene_names_refseq": "PKARIIbeta; Pkarb2; Prkar2b; RII(beta)", "protein_names_uniprotkb": "cAMP-dependent protein kinase type II-beta regulatory subunit", "protein_names_refseq": "cAMP-dependent protein kinase type II-beta regulatory subunit isoform 1; cAMP-dependent protein kinase type II-beta regulatory subunit", "tax_id": 10090, "disease": "granulosa cell tumor (Disease Ontology:DOID:2999)", "pathway": " (mmu:19088); (R-MMU-163615); (R-MMU-164378); (R-MMU-180024); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-432040); (R-MMU-442720); (R-MMU-5610787); (R-MMU-5620912); (R-MMU-8854518); (R-MMU-9634597); (R-MMU-983231); (R-MMU-9856530)", "pathway_count": 17, "publication_count": 17, "publication_id_list": "15822905;16452087;17114649;17242355;19131326;2069562;21183079;21750661;22323819;26495903;28011936;28135057;28528544;29518769;33300544;33649504;36529950", "class_list": "", "function": "PKA-RIIbeta autophosphorylation modulates PKA activity and seizure phenotypes in mice. Publication Status: Online-Only, [RefSeq, PubMed]; RIIbeta-PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning., [RefSeq, PubMed]; RNAi-mediated Prkar2b suppression resulted in MI-stage arrest during oocyte development, and these oocytes exhibited abnormal spindle formation and chromosome aggregation., [RefSeq, PubMed]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1B199;Q3UTZ1;Q80ZM4;Q8BRZ7", "ec_number_list": "", "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0008603 cAMP-dependent protein kinase regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007612 learning;GO:0050804 modulation of chemical synaptic transmission;GO:0045859 regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P31324-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88713-1", "uniprot_id": "KLRG1_MOUSE", "mass": 21396.0, "length": 188, "protein_name": "Killer cell lectin-like receptor subfamily G member 1", "gene_name": "Klrg1", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor subfamily G member 1", "refseq_ac": "NP_058666", "gene_names_uniprotkb": "Klrg1; Mafa", "gene_names_refseq": "2F1-Ag; Klrg1; MAFA-L; MAFA", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily G member 1; Mast cell function-associated antigen 2F1", "protein_names_refseq": "killer cell lectin-like receptor subfamily G member 1; mast cell function-associated antigen 2F1", "tax_id": 10090, "disease": "", "pathway": " (mmu:50928)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11220622;11673487;11884419;16424155;17307799;19604491;34764950;9862378;9862665", "class_list": "glycogene", "function": "Both pathogenic and nonpathogenic in vivo activation of NK cells induces cell surface expression of KLRG1, while in vitro studies show that engagement of the receptor on a transfected NK cell line inhibits cytokine production and cell-mediated cytoxicity., [RefSeq, PubMed]; Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells., [UniProtKB, PubMed]; Single-Cell Sequencing Reveals the Novel Role of Ezh2 in NK Cell Maturation and Function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3T1F0", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88713-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19137-1", "uniprot_id": "LAMA1_MOUSE", "mass": 338148.0, "length": 3083, "protein_name": "Laminin subunit alpha-1", "gene_name": "Lama1", "organism": "Mouse", "refseq_name": "laminin subunit alpha-1 precursor", "refseq_ac": "NP_032506", "gene_names_uniprotkb": "Lama1; Lama-1; Lama", "gene_names_refseq": "Lama1; Lama", "protein_names_uniprotkb": "Laminin subunit alpha-1; Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-LAM alpha; S-laminin subunit alpha", "protein_names_refseq": "S-LAM alpha; S-laminin subunit alpha; laminin A chain; laminin subunit alpha-1 precursor; laminin subunit alpha-1; laminin-1 subunit alpha; laminin-3 subunit alpha", "tax_id": 10090, "disease": "muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:16772)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10022829;10366602;10893232;11304538;11798066;11829758;12402286;16475793;18044967;19349973;25428506;30084848;30899004;3181157;3182802;3267223;33300544;8354280;9454835", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (PubMed:10366602, PubMed:11798066). As a ligand for alpha-dystroglycan, it is involved in a number of processes including epithelium branching morphogenesis, down-regulation of apoptotic signals in muscle via the activation of PI3K/AKT signaling, and activation of RAC1 signaling (PubMed:10366602, PubMed:11798066, PubMed:12402286, PubMed:16475793, PubMed:18044967). As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway (PubMed:9454835)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 14, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 29, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 29, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 29, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 23, "disease_count": 1, "glyco_site_count": 33, "binding_glycan_count": 0, "secondary_ac_list": "F8VQ40", "ec_number_list": "", "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0048018 receptor ligand activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0031175 neuron projection development;GO:0045198 establishment of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 7.4, "record_id": "P19137-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26262-1", "uniprot_id": "KLKB1_MOUSE", "mass": 71383.0, "length": 638, "protein_name": "Plasma kallikrein", "gene_name": "Klkb1", "organism": "Mouse", "refseq_name": "plasma kallikrein preproprotein", "refseq_ac": "NP_032481", "gene_names_uniprotkb": "Klkb1; Klk3; Pk", "gene_names_refseq": "APS; Kal-3; Kal3; Klk3; Klkb1; PSA", "protein_names_uniprotkb": "Plasma kallikrein; 3.4.21.34; Fletcher factor; Kininogenin; Plasma prekallikrein", "protein_names_refseq": "antigen, prostate specific; fletcher factor; kallikrein 3, plasma; kininogenin; plasma kallikrein preproprotein; plasma kallikrein; plasma prekallikrein", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); lupus nephritis (Disease Ontology:DOID:0080162); hypertension (Disease Ontology:DOID:10763); glomerulonephritis (Disease Ontology:DOID:2921); liver cirrhosis (Disease Ontology:DOID:5082); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:16621); (R-MMU-1592389); (R-MMU-9855719); (R-MMU-9935598); (R-MMU-9970672)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16944957;17330941;2264928;31451224;31595971;34428180;35189703;39627609", "class_list": "", "function": "Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis., [RefSeq, PubMed]; Circulating PKK confines pro-inflammatory signaling in the lung by a mechanism that does not involve contact system activation, which in the case of respiratory tract infection may impede early protective innate immunity., [RefSeq, PubMed]; In ambient particulate matter-induced lung injury model, Klkb1(-/-) mice exhibited a decrease in total protein, cells numbers in bronchoalveolar lavage fluid (BALF) and histologic lung injury score. The TNF-alpha and IL-6 levels in BALF were significantly decreased in ambient particulate matter-treated Klkb1(-/-) mice., [RefSeq, PubMed]; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin., [UniProtKB]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric enzyme comprised of heavy and light chains. A complete deletion of the encoded protein prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding. [provided by RefSeq, May 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0P5", "ec_number_list": "3.4.21.4;3.4.21.22;3.4.21.39;3.4.21.59;3.4.21.34;3.4.21.20;3.4.24.17;3.4.21.37;3.4.16.2;3.4.21.38;3.4.21.1;3.4.24.7", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0007597 blood coagulation, intrinsic pathway;GO:0042730 fibrinolysis;GO:0031639 plasminogen activation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P26262-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27812-1", "uniprot_id": "KRBBA_MOUSE", "mass": 25158.0, "length": 223, "protein_name": "Killer cell lectin-like receptor subfamily B member 1B allele A", "gene_name": "Klrb1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Klrb1b; Klrb1d; Ly55b; Ly55d; Nkrp1b; Nkrp1d", "gene_names_refseq": "", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily B member 1B allele A; CD161 antigen-like family member B; Ly-55b; Lymphocyte antigen 55b; NKR-P1 34; NKR-P1B; Natural killer cell surface protein NKR-P1B allele SJL/BALB", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:80782)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10229823;10229828;11685472;12858173;14990792;1517565;15814704;16751398;1880421;21750661;9390275", "class_list": "glycogene", "function": "Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent 'missing-self' recognition of allografts, tumor cells and virus-infected cells., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 39, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RSI6;Q1WJB7;Q548H2;Q61969", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0045953 negative regulation of natural killer cell mediated cytotoxicity;GO:0042269 regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P27812-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58334-1", "uniprot_id": "KLF16_MOUSE", "mass": 25652.0, "length": 251, "protein_name": "Krueppel-like factor 16", "gene_name": "Klf16", "organism": "Mouse", "refseq_name": "Krueppel-like factor 16", "refseq_ac": "NP_510962", "gene_names_uniprotkb": "Klf16; Bteb4; Drrf", "gene_names_refseq": "BTEB4; DRRF; Klf16", "protein_names_uniprotkb": "Krueppel-like factor 16; BTE-binding protein 4; Basic transcription element-binding protein 4; Dopamine receptor-regulating factor; Transcription factor BTEB4", "protein_names_refseq": "BTE-binding protein 4; Krueppel-like factor 16; Kruppel-like factor 16; basic transcription element-binding protein 4; dopamine receptor regulating factor; transcription factor BTEB4", "tax_id": 10090, "disease": "", "pathway": " (mmu:118445)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11390978;11744383;21183079;27402841;27611969;31219806;34823421;36852467", "class_list": "", "function": "DRRF mRNA is expressed uniquely during development at all time points tested with high levels observed at E12, E14 and E16 in various tissues, [RefSeq, PubMed]; Knock out hepatic Kruppel-like factor 16 (KLF16) improve myocardial damage and promoted myocardial protection of myocardial ischemia-reperfusion via anti-oxidative and anti-inflammation effects by TFAM/PPARbeta signal passage., [RefSeq, PubMed]; Methylation of only six of 98 CpG dinucleotides within the EphA5 promoter blocks its transactivation by KLF16 but enables transactivation by KLF2 and KLF15. Erratum:[J Biol Chem. 2016 Oct 7;291(41):21422. doi: 10.1074/jbc.A116.732339. PMID: 27825077], [RefSeq, PubMed]; Results indicate that KLF16 inhibits adipogenesis through downregulation of PPARgamma expression Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that binds GC and GT boxes in the D1A, D2 and D3 dopamine receptor promoters and displaces Sp1 and Sp3 from these sequences. It modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3Y4;Q8C8S2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007212 G protein-coupled dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P58334-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01768-1", "uniprot_id": "NDKB_MOUSE", "mass": 17363.0, "length": 152, "protein_name": "Nucleoside diphosphate kinase B", "gene_name": "Nme2", "organism": "Mouse", "refseq_name": "nucleoside diphosphate kinase B", "refseq_ac": "NP_001070997", "gene_names_uniprotkb": "Nme2", "gene_names_refseq": "NDPK B; NDPK2; NM23-H2; NM23B; Nme2; nm23-M2", "protein_names_uniprotkb": "Nucleoside diphosphate kinase B; 2.7.13.3; 2.7.4.6; Histidine protein kinase NDKB; NDP kinase B; NDPK B; NDPK2; Nucleoside diphosphate kinases 2; P18; nm23-M2", "protein_names_refseq": "NDK B; NDP kinase B; P18; expressed in non-metastatic cells 2 protein; histidine protein kinase NDKB; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase B; nucleoside diphosphate kinases 2; nucleoside-diphosphate kinase 2", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); teratoma (Disease Ontology:DOID:3307); ovarian carcinoma (Disease Ontology:DOID:4001); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:18103); (R-MMU-499943); (R-MMU-6798695); (R-MMU-9748787); (R-MMU-9755088)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "1325378;16476741;17532299;20884616;22645316;25605945;26740625;33024267;33086728;33725478;34428180;34433909;36288343;37453647;37672589;37828378;39927985", "class_list": "", "function": "Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:1325378). Also functions as a histidine protein kinase by transferring the phosphoryl group from the phosphohistidine intermediate to a histidine residue in target proteins (By similarity). Phosphorylates the GNB1 subunit of heterotrimeric G proteins at 'His-266', generating a high-energy phosphate group that promotes GTP formation and enables receptor-independent activation of heterotrimeric G proteins (By similarity). Also phosphorylates KCNN4 at 'His-358', leading to activation of its intermediate conductance calcium-activated potassium channel activity, Ca(2+) influx, and subsequent activation of B and T cells. Additionally involved in transcriptional regulation through direct DNA binding and chromatin remodeling. In this context, functions as a single-stranded DNA binding protein that binds and stabilizes the G-quadruplex (G4) structures within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter, facilitating recruitment of additional single-strand DNA binding proteins and activation of MYC transcription. G4 DNA-binding activity is independent of its nucleoside diphosphate kinase function and recognizes both folded and unfolded G4 structures (By similarity). With NME1, may regulate acetyl-CoA (AcCoA) usage between histone acetylation and fatty acid synthesis by targeting AcCoA release at ATP-rich, HAT-associated chromatin regions (PubMed:37672589). Also negatively regulates Rho activity by interacting with AKAP13/LBC (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients. Erratum:[Oncogene. 2021 Nov;40(45):6394. doi: 10.1038/s41388-021-02045-4. PMID: 34635800], [RefSeq, PubMed]; Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity. Publication Status: Online-Only, [RefSeq, PubMed]; Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.25;3.2.1.33;2.7.4.6;2.7.4.4;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;2.7.10.2;3.1.11.-;2.7.11.1;2.7.13.3;2.7.4.18;3.1.24.-;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.1.40;3.5.4.5;3.4.25.1;2.7.11.39;3.6.4.6;2.7.4.3;2.7.1.1;2.7.1.-;2.7.4.14;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;2.7.1.35;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0003677 DNA binding;GO:0004674 protein serine/threonine kinase activity;GO:0005504 fatty acid binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030027 lamellipodium", "go_biological_process": "GO:0006231 dTMP biosynthetic process;GO:0006351 DNA-templated transcription;GO:0007229 integrin-mediated signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q01768-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62083-1", "uniprot_id": "PICK1_MOUSE", "mass": 46597.0, "length": 416, "protein_name": "PRKCA-binding protein", "gene_name": "Pick1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pick1; Prkcabp", "gene_names_refseq": "", "protein_names_uniprotkb": "PRKCA-binding protein; Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:18693); (R-MMU-416993)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10340301;11278603;12065412;14976185;20445062;21750661;21952136;24068808;24069373;25605945;30779550;34428180;35820727;7844141;9405395;9883737", "class_list": "", "function": "Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PY04", "ec_number_list": "", "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding;GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015844 monoamine transport;GO:0021782 glial cell development;GO:0036294 cellular response to decreased oxygen levels;GO:0006468 protein phosphorylation;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q62083-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q793I8-1", "uniprot_id": "TIFA_MOUSE", "mass": 21560.0, "length": 184, "protein_name": "TRAF-interacting protein with FHA domain-containing protein A", "gene_name": "Tifa", "organism": "Mouse", "refseq_name": "TRAF-interacting protein with FHA domain-containing protein A", "refseq_ac": "NP_660115", "gene_names_uniprotkb": "Tifa; T2bp", "gene_names_refseq": "T2bp; Tifa", "protein_names_uniprotkb": "TRAF-interacting protein with FHA domain-containing protein A; TRAF2-binding protein", "protein_names_refseq": "TRAF-interacting protein with FHA domain-containing protein A; Traf2 binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:211550); (R-MMU-445989); (R-MMU-9645460)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11798190;12566447;16643855;23722163;32198460", "class_list": "", "function": "Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (PubMed:11798190). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (By similarity). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling (By similarity)., [UniProtKB, UniProtKB, PubMed]; TIFA is likely to mediate IRAK-1/TRAF6 interaction upon IL-1 stimulation, [RefSeq, PubMed]; The increase in TIFA level appears to be a feed-forward mechanism involved in TLR4/MyD88-dependent signaling, leading to NF-kappaB activation and HMGB1 release, [RefSeq, PubMed]; We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6-dependent activation of NF-kappaB. Erratum:[Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLY9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q793I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTV6-1", "uniprot_id": "UBP18_MOUSE", "mass": 42472.0, "length": 368, "protein_name": "Ubl carboxyl-terminal hydrolase 18", "gene_name": "Usp18", "organism": "Mouse", "refseq_name": "ubl carboxyl-terminal hydrolase 18", "refseq_ac": "NP_036039", "gene_names_uniprotkb": "Usp18; Ubp43", "gene_names_refseq": "1110058H21Rik; UBP43; Ubp15; Usp18", "protein_names_uniprotkb": "Ubl carboxyl-terminal hydrolase 18; 3.4.19.12; 43 kDa ISG15-specific protease; ISG15-specific-processing protease; Ubl thioesterase 18", "protein_names_refseq": "43 kDa ISG15-specific protease; ISG15-specific-processing protease; ubiquitin specific protease 15; ubiquitin specific protease 18; ubl carboxyl-terminal hydrolase 18; ubl thioesterase 18; ubl thiolesterase 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:24110); (R-MMU-1169408); (R-MMU-445989); (R-MMU-5689880); (R-MMU-912694); (R-MMU-9758274)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10082570;11788588;12208842;12600939;21750661", "class_list": "", "function": "Interferon-induced ISG15-specific protease that plays a crucial role for maintaining a proper balance of ISG15-conjugated proteins in cells (PubMed:11788588). Regulates protein ISGylation by efficiently cleaving ISG15 conjugates linked via isopeptide bonds. Regulates T-cell activation and T-helper 17 (Th17) cell differentiation by deubiquitinating TAK1, likely to keep TAK1-TAB complexes in steady conditions. In turn, restricts activation of NF-kappa-B, NFAT, and JNK as well as expression of IL2 in T-cells after TCR activation. Acts as a molecular adapter with USP20 to promote innate antiviral response through deubiquitinating STING1. Involved also in the negative regulation of the inflammatory response triggered by type I interferon. Upon recruitment by STAT2 to the type I interferon receptor subunit IFNAR2 interferes with the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and acts as a negative regulator of the type I interferon signaling pathway., [UniProtKB, UniProtKB, PubMed]; These findings identify UBP43 as a novel negative regulator of IFN signaling and suggest the involvement of protein ISGylation in the regulation of the JAK-STAT pathway., [RefSeq, PubMed]; UBP43 (USP18) specifically removes ISG15 from conjugated proteins, [RefSeq, PubMed]; UBP43 plays a critical role in maintaining the homeostatic balance of ISG15-conjugated protein, and that regulation of cellular levels of ISG15 protein modification is essential for brain cell function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7P3", "ec_number_list": "2.7.11.10;2.7.11.1;2.7.10.2;2.3.2.24;2.3.2.23;2.7.11.25;3.1.4.11;2.7.11.24;3.6.4.13;3.4.19.12", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0019785 ISG15-specific peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0009617 response to bacterium;GO:0031647 regulation of protein stability;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WTV6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19426-1", "uniprot_id": "NELFE_MOUSE", "mass": 42554.0, "length": 375, "protein_name": "Negative elongation factor E", "gene_name": "Nelfe", "organism": "Mouse", "refseq_name": "negative elongation factor E", "refseq_ac": "NP_001039328", "gene_names_uniprotkb": "Nelfe; D17h6s45; Rdbp; Rd", "gene_names_refseq": "D17H6S45; NELF-E; Nelfe; RD; Rdbp", "protein_names_uniprotkb": "Negative elongation factor E; NELF-E; RNA-binding protein RD", "protein_names_refseq": "RD RNA-binding protein; RNA-binding protein RD; negative elongation factor E", "tax_id": 10090, "disease": "", "pathway": " (mmu:27632); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6796648); (R-MMU-75955)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "14656967;15345747;17242355;19144319;21183079;21750661;25428506;26010750;30059200;31219806;31399344;3353717;9321489", "class_list": "", "function": "Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:31399344). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:31399344). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97485;P97486;Q9CZN3", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016604 nuclear body;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0031401 positive regulation of protein modification process;GO:0034244 negative regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P19426-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04863-1", "uniprot_id": "RELB_MOUSE", "mass": 60305.0, "length": 558, "protein_name": "Transcription factor RelB", "gene_name": "Relb", "organism": "Mouse", "refseq_name": "transcription factor RelB isoform 2", "refseq_ac": "NP_001277386", "gene_names_uniprotkb": "Relb", "gene_names_refseq": "Relb; shep", "protein_names_uniprotkb": "Transcription factor RelB", "protein_names_refseq": "avian reticuloendotheliosis viral (v-rel) oncogene related B; transcription factor RelB isoform 2; transcription factor relB", "tax_id": 10090, "disease": "immunodeficiency 53 (Disease Ontology:DOID:0111992); bacterial infectious disease (Disease Ontology:DOID:104); prediabetes syndrome (Disease Ontology:DOID:11716); breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); atopic dermatitis (Disease Ontology:DOID:3310); ureteral obstruction (Disease Ontology:DOID:5199); kidney disease (Disease Ontology:DOID:557); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:19698); (R-MMU-5607761); (R-MMU-5621575); (R-MMU-5676590)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "11781828;11931770;12874295;16154093;1732739;17869269;21750661;22565310;22894897;30084848;34203471;34428180;36210013;38705503;7845467;8441398", "class_list": "", "function": "NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; TET1 mediated m5C modification of RelB aggravates cerebral ischemia/reperfusion-induced neuroinflammation through regulating microglia polarization. Erratum:[Cell Signal. 2024 Dec;124:111367. doi: 10.1016/j.cellsig.2024.111367. PMID: 39214841], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VE46", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q04863-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02468-1", "uniprot_id": "LAMC1_MOUSE", "mass": 177298.0, "length": 1607, "protein_name": "Laminin subunit gamma-1", "gene_name": "Lamc1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lamc1; Lamb-2; Lamc-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Laminin subunit gamma-1; Laminin B2 chain; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit gamma; S-LAM gamma; S-laminin subunit gamma", "protein_names_refseq": "", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:226519)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10.1101/2023.09.13.557529;18250455;19349973;20484733;21750661;21952136;22872234;25428506;26495903;28315936;2836421;29187734;30059200;30899004;31219806;31599954;3167041;33300544;34428180;36210013;36288343;36792666;3680290;36852467;37507081;39927985;40885482;6209134;8648630;8648631;9454835", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway (PubMed:9454835)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 13, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 12, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 44, "disease_count": 1, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0048018 receptor ligand activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction;GO:0043083 synaptic cleft;GO:0005604 basement membrane", "go_biological_process": "GO:0048729 tissue morphogenesis;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0022617 extracellular matrix disassembly", "synthesized_glycan_count": 0, "hit_score": 9.2, "record_id": "P02468-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15307-1", "uniprot_id": "REL_MOUSE", "mass": 64960.0, "length": 587, "protein_name": "Proto-oncogene c-Rel", "gene_name": "Rel", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rel", "gene_names_refseq": "", "protein_names_uniprotkb": "Proto-oncogene c-Rel", "protein_names_refseq": "", "tax_id": 10090, "disease": "immunodeficiency 92 (Disease Ontology:DOID:0061062); bacterial infectious disease (Disease Ontology:DOID:104); breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671)", "pathway": " (R-MMU-1169091)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "19224205;20173027;2204017;2204816;23646894;2654811;27927986;28315936;31219806;32170099;32782141;34428180;8816457", "class_list": "", "function": "Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0010629 negative regulation of gene expression;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P15307-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43431-1", "uniprot_id": "IL12A_MOUSE", "mass": 24179.0, "length": 215, "protein_name": "Interleukin-12 subunit alpha", "gene_name": "Il12a", "organism": "Mouse", "refseq_name": "interleukin-12 subunit alpha isoform 2 precursor", "refseq_ac": "NP_032377", "gene_names_uniprotkb": "Il12a; IL12A", "gene_names_refseq": "IL-12p35; Il-12a; Il12a; Ll12a; p35", "protein_names_uniprotkb": "Interleukin-12 subunit alpha; CLMF p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12A", "protein_names_refseq": "CLMF p35; IL-12 p35 subunit; IL-12 subunit p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; interleukin 12a p35 subunit; interleukin-12 p35 subunit; interleukin-12 subunit alpha isoform 2 precursor; interleukin-12 subunit alpha", "tax_id": 10090, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); hepatitis C (Disease Ontology:DOID:1883); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:16159); (R-MMU-8984722); (R-MMU-9020591)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;1350290;18033300;21750661;30197594;34374750;8557982;8647196;8766560", "class_list": "", "function": "Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005143 interleukin-12 receptor binding;GO:0042163 interleukin-12 beta subunit binding;GO:0045513 interleukin-27 binding;GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0043514 interleukin-12 complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0032946 positive regulation of mononuclear cell proliferation;GO:0045063 T-helper 1 cell differentiation;GO:0051142 positive regulation of NK T cell proliferation;GO:0035711 T-helper 1 cell activation;GO:0050709 negative regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P43431-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6F5E0-1", "uniprot_id": "TM158_MOUSE", "mass": 29145.0, "length": 286, "protein_name": "Transmembrane protein 158", "gene_name": "Tmem158", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tmem158; Mbbp; Ris1", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein 158; 40 kDa BINP-binding protein; Ras-induced senescence protein 1; p40BBP", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;16964279;30899004", "class_list": "", "function": "Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042277 peptide binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6F5E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8N7N6-1", "uniprot_id": "CIKS_MOUSE", "mass": 62440.0, "length": 555, "protein_name": "E3 ubiquitin ligase TRAF3IP2", "gene_name": "Traf3ip2", "organism": "Mouse", "refseq_name": "E3 ubiquitin ligase TRAF3IP2", "refseq_ac": "NP_598761", "gene_names_uniprotkb": "Traf3ip2", "gene_names_refseq": "Act1; CIKS; Traf3ip2", "protein_names_uniprotkb": "E3 ubiquitin ligase TRAF3IP2; 2.3.2.27; ACT1; Adapter protein CIKS; Connection to IKK and SAPK/JNK; E3 ubiquitin-protein ligase CIKS; Nuclear factor NF-kappa-B activator 1; TRAF3-interacting protein 2", "protein_names_refseq": "E3 ubiquitin ligase TRAF3IP2; E3 ubiquitin-protein ligase CIKS; adapter protein CIKS; connection to IKK and SAPK/JNK; nuclear factor NF-kappa-B activator 1", "tax_id": 10090, "disease": "psoriasis 13 (Disease Ontology:DOID:0111287); Sjogren's syndrome (Disease Ontology:DOID:12894); chronic mucocutaneous candidiasis (Disease Ontology:DOID:2058); atopic dermatitis (Disease Ontology:DOID:3310); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:103213)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12477932;17035243;19825828;33723527;33941656;36978108", "class_list": "", "function": "Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor, [RefSeq, PubMed]; E3 ubiquitin ligase that catalyzes 'Lys63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (By similarity). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (By similarity). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828)., [UniProtKB, UniProtKB, PubMed, PubMed]; Identification of a Long Noncoding RNA TRAF3IP2-AS1 as Key Regulator of IL-17 Signaling through the SRSF10-IRF1-Act1 Axis in Autoimmune Diseases., [RefSeq, PubMed]; NF-kappaB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH33", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0023035 CD40 signaling pathway;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007507 heart development;GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8N7N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66JY2-3", "uniprot_id": "IN80D_MOUSE", "mass": 112362.0, "length": 1021, "protein_name": "INO80 complex subunit D", "gene_name": "Ino80d", "organism": "Mouse", "refseq_name": "INO80 complex subunit D isoform 2", "refseq_ac": "NP_001074905", "gene_names_uniprotkb": "Ino80d", "gene_names_refseq": "7330405I11; A430093A21Rik; Ino80d", "protein_names_uniprotkb": "INO80 complex subunit D", "protein_names_refseq": "INO80 complex subunit D isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:227195); (R-MMU-5689603); (R-MMU-5696394)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q9Q0;E9QLE8;Q8BQK5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0031011 Ino80 complex", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66JY2-3", "record_type": "protein" }, { "uniprot_canonical_ac": "P01627-1", "uniprot_id": "KV2A2_MOUSE", "mass": 13280.0, "length": 120, "protein_name": "Immunoglobulin kappa variable 2-112", "gene_name": "Igkv2-112", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Igkv2-112; Gm5153", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin kappa variable 2-112; Ig kappa chain V-II region VKappa167", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "21750661;6776396;6791832;99160", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex;GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01627-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14BP6-1", "uniprot_id": "LR74B_MOUSE", "mass": 41701.0, "length": 391, "protein_name": "Leucine-rich repeat-containing protein 74B", "gene_name": "Lrrc74b", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 74B isoform 2", "refseq_ac": "NP_001138907", "gene_names_uniprotkb": "Lrrc74b", "gene_names_refseq": "4930451C15Rik; Lrrc74b; mCG12354; mCP17390", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 74B", "protein_names_refseq": "leucine-rich repeat-containing protein 74B isoform 2; leucine-rich repeat-containing protein 74B; leucine-rich repeat-containing protein LOC400891 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74685)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPS2;Q8BYL7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q14BP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61327-1", "uniprot_id": "MGN_MOUSE", "mass": 17164.0, "length": 146, "protein_name": "Protein mago nashi homolog", "gene_name": "Magoh", "organism": "Mouse", "refseq_name": "protein mago nashi homolog", "refseq_ac": "NP_001269666", "gene_names_uniprotkb": "Magoh", "gene_names_refseq": "Mago-m; Magoh; Mos2", "protein_names_uniprotkb": "Protein mago nashi homolog", "protein_names_refseq": "mago-nashi homolog, proliferation-associated; protein mago nashi homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:17149); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-975957)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "20364144;23917022;27618312;31857347;9272960;9479507", "class_list": "", "function": "Findings implicate Magoh as a crucial regulator of interneuron development Publication Status: Online-Only, [RefSeq, PubMed]; Magoh haploinsufficiency causes microcephaly because of intermediate neural progenitors depletion and neuronal apoptosis., [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S pre-initiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly., [UniProtKB, UniProtKB]; We first show that Eif4a3 haploinsufficiency phenocopies aberrant neurogenesis and microcephaly of Magoh and Rbm8a mutant mice.we show that genetic ablation of one downstream pathway, p53, significantly rescues microcephaly of all 3 EJC mutant Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A8E0;O35169;P50606", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P61327-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64321-1", "uniprot_id": "ZBT7B_MOUSE", "mass": 58918.0, "length": 544, "protein_name": "Zinc finger and BTB domain-containing protein 7B", "gene_name": "Zbtb7b", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 7B", "refseq_ac": "NP_033591", "gene_names_uniprotkb": "Zbtb7b; Thpok; Zfp67", "gene_names_refseq": "Thpok; Zbtb7b; Zfp67; c-Krox", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 7B; Krueppel-related zinc finger protein cKrox; T-helper-inducing POZ/Krueppel-like factor; Zfp-67; Zinc finger protein 67; Zinc finger protein Th-POK; c-Krox", "protein_names_refseq": "T-helper-inducing POZ/Krueppel-like factor; Vzinc finger and BTB domain containing 7B; krueppel-related zinc finger protein cKrox; zinc finger and BTB domain-containing protein 7B; zinc finger protein 67; zinc finger protein Th-POK", "tax_id": 10090, "disease": "", "pathway": " (mmu:22724)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15729333;18258917;20810990;21750661;22730529;23105140;23481257;24880459;28784777;29420538;38225233;7937772", "class_list": "", "function": "Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner (PubMed:15729333, PubMed:29420538). Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision (PubMed:15729333, PubMed:18258917, PubMed:23481257, PubMed:24880459). Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate (PubMed:24880459). During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci (PubMed:22730529). Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells (PubMed:23105140). Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (PubMed:29420538). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:7937772). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation (PubMed:28784777). Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (PubMed:28784777)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VV5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0032740 positive regulation of interleukin-17 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q64321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61831-1", "uniprot_id": "MK10_MOUSE", "mass": 52532.0, "length": 464, "protein_name": "Mitogen-activated protein kinase 10", "gene_name": "Mapk10", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 10 isoform 5", "refseq_ac": "NP_001297615", "gene_names_uniprotkb": "Mapk10; Jnk3; Prkm10; Serk2", "gene_names_refseq": "C230008H04Rik; JNK3B1; JNK3B2; JNK3; Mapk10; SAPK(beta); Serk2; p493F12; p54bSAPK", "protein_names_uniprotkb": "Mitogen-activated protein kinase 10; 2.7.11.24; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3", "protein_names_refseq": "JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; MAP kinase 10; MAP kinase p49 3F12; SAPK/Erk/kinase 2; c-Jun N-terminal kinase 3; mitogen-activated protein kinase 10 isoform 5; stress-activated protein kinase JNK3", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (mmu:26414); (R-MMU-2559580); (R-MMU-2871796); (R-MMU-450321); (R-MMU-450341)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10471813;10523642;16611996;17724133;20418776;21554942;21750661;22441692;38936368;8717339;9349820", "class_list": "", "function": "Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization., [RefSeq, PubMed]; Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Also participates in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0U6", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0005524 ATP binding;GO:0004705 JUN kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0007258 JUN phosphorylation;GO:0098969 neurotransmitter receptor transport to postsynaptic membrane;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q61831-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XG9-1", "uniprot_id": "LRRT4_MOUSE", "mass": 67148.0, "length": 590, "protein_name": "Leucine-rich repeat transmembrane neuronal protein 4", "gene_name": "Lrrtm4", "organism": "Mouse", "refseq_name": "leucine-rich repeat transmembrane neuronal protein 4 isoform 3 precursor", "refseq_ac": "NP_001128215", "gene_names_uniprotkb": "Lrrtm4", "gene_names_refseq": "7530419J18Rik; A230052N11; Lrrtm4", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane neuronal protein 4", "protein_names_refseq": "leucine-rich repeat transmembrane neuronal protein 4 isoform 3 precursor; leucine-rich repeat transmembrane neuronal protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:243499); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12676565;16452087;21750661;22632720;22645316;23911104;31974009;31995730;32390181;33300544", "class_list": "", "function": "LRRTM4 is a key synapse organizing molecule at rod bipolar cell (RBC) terminals, where it regulates function of GABAergic synapse and assembly of RBC synaptic dyads., [RefSeq, PubMed]; LRRTM4 is a member of the transsynaptic complex between rod photoreceptors and bipolar cells., [RefSeq, PubMed]; LRRTMs engage the protein domains of Nrx but require its heparan sulfate (HS) modification to induce presynaptic differentiation. Binding to HS of Nrx is sufficient for LRRTM3 and LRRTM4 to induce synaptogenesis. Nrx1gamma is a potent synapse organizer and LRRTM4 is its postsynaptic ligand. Mice expressing a mutant form of LRRTM4 that can't bind HS show structural and functional deficits at dentate gyrus excitatory syn... Erratum:[Neuron. 2020 May 20;106(4):701. doi: 10.1016/j.neuron.2020.05.003. PMID: 32437657], [RefSeq, PubMed]; May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity)., [UniProtKB]; This study demonistrated that LRRTM4-HSPG complex mediates excitatory synapse development on dentate gyrus granule cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C030;Q8JZS8", "ec_number_list": "", "go_molecular_function": "GO:0043395 heparan sulfate proteoglycan binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0050808 synapse organization;GO:0051965 positive regulation of synapse assembly;GO:0051963 regulation of synapse assembly;GO:0097113 AMPA glutamate receptor clustering;GO:0072578 neurotransmitter-gated ion channel clustering", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q80XG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1S1-1", "uniprot_id": "LGI4_MOUSE", "mass": 59377.0, "length": 537, "protein_name": "Leucine-rich repeat LGI family member 4", "gene_name": "Lgi4", "organism": "Mouse", "refseq_name": "leucine-rich repeat LGI family member 4 isoform 1 precursor", "refseq_ac": "NP_653139", "gene_names_uniprotkb": "Lgi4; Lgil3", "gene_names_refseq": "Lgi4; Lgil3; clp", "protein_names_uniprotkb": "Leucine-rich repeat LGI family member 4; LGI1-like protein 3; Leucine-rich glioma-inactivated protein 4", "protein_names_refseq": "LGI1-like protein 3; leucine-rich glioma inactivated protein 4; leucine-rich repeat LGI family member 4 isoform 1 precursor", "tax_id": 10090, "disease": "arthrogryposis multiplex congenita-1 (Disease Ontology:DOID:0080978); childhood absence epilepsy (Disease Ontology:DOID:1825)", "pathway": " (mmu:243914); (R-MMU-5682910)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12095917;12217514;16341215;18974846;19833108;21750661", "class_list": "", "function": "Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4Y8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0021782 glial cell development;GO:0008344 adult locomotory behavior;GO:0042552 myelination;GO:0022011 myelination in peripheral nervous system;GO:0031641 regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K1S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04859-1", "uniprot_id": "MAK_MOUSE", "mass": 70080.0, "length": 622, "protein_name": "Serine/threonine-protein kinase MAK", "gene_name": "Mak", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase MAK isoform 3", "refseq_ac": "NP_001139274", "gene_names_uniprotkb": "Mak; Rck", "gene_names_refseq": "A930010O05Rik; Mak", "protein_names_uniprotkb": "Serine/threonine-protein kinase MAK; 2.7.11.1; Male germ cell-associated kinase; Protein kinase RCK", "protein_names_refseq": "protein kinase RCK; serine/threonine-protein kinase MAK isoform 3; serine/threonine-protein kinase MAK", "tax_id": 10090, "disease": "retinitis pigmentosa 62 (Disease Ontology:DOID:0110380)", "pathway": " (mmu:17152)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11971961;1473268;21148103;21750661;24244486;34428180;8359591", "class_list": "", "function": "Data show that function of MAK is not essential for spermatogenesis and male fertility., [RefSeq, PubMed]; Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Could have an important function in sensory cells and in spermatogenesis. May participate in signaling pathways used in visual and olfactory sensory transduction. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR (By similarity)., [UniProtKB, PubMed]; The expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q4B2;E9QAU5;E9QKR3;Q8CDL5", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0045494 photoreceptor cell maintenance;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q04859-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVU0-1", "uniprot_id": "LRCH3_MOUSE", "mass": 86341.0, "length": 778, "protein_name": "DISP complex protein LRCH3", "gene_name": "Lrch3", "organism": "Mouse", "refseq_name": "DISP complex protein LRCH3 isoform 1", "refseq_ac": "NP_001074724", "gene_names_uniprotkb": "Lrch3", "gene_names_refseq": "2210409B11Rik; Gm1742; Lrch3", "protein_names_uniprotkb": "DISP complex protein LRCH3; Leucine-rich repeat and calponin homology domain-containing protein 3", "protein_names_refseq": "DISP complex protein LRCH3 isoform 1; DISP complex protein LRCH3; leucine-rich repeat and calponin homology domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:70144)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17971504;21183079;21750661;22872234;31219806;31599954;32782141;34428180;34678516;35820727;36210013", "class_list": "", "function": "As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton., [UniProtKB, UniProtKB]; Lrch3 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RXA0;Q3U222;Q3UZ74", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0032185 septin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BVU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08605-1", "uniprot_id": "MKNK1_MOUSE", "mass": 47915.0, "length": 427, "protein_name": "MAP kinase-interacting serine/threonine-protein kinase 1", "gene_name": "Mknk1", "organism": "Mouse", "refseq_name": "MAP kinase-interacting serine/threonine-protein kinase 1 isoform b", "refseq_ac": "NP_001272417", "gene_names_uniprotkb": "Mknk1; Mnk1", "gene_names_refseq": "2410048M24Rik; Mknk1; Mnk1", "protein_names_uniprotkb": "MAP kinase-interacting serine/threonine-protein kinase 1; 2.7.11.1; MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1", "protein_names_refseq": "MAP kinase-interacting serine/threonine-protein kinase 1 isoform b; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal-integrating kinase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17346); (R-MMU-1295596)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15234964;15254222;21183079;21750661;23269249;9155017", "class_list": "", "function": "May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap., [UniProtKB, PubMed]; Mnk1 phosphorylation by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk, [RefSeq, PubMed]; Mnk1/2 has a minimal role in T cell development and activation but may regulate non-T cell lineages to control Th1 and Th17 differentiation in vivo., [RefSeq, PubMed]; Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development, [RefSeq, PubMed]; This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.1.3.16;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0009651 response to salt stress;GO:0006446 regulation of translational initiation;GO:0018105 peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O08605-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0M2-1", "uniprot_id": "LRC36_MOUSE", "mass": 83763.0, "length": 755, "protein_name": "Leucine-rich repeat-containing protein 36", "gene_name": "Lrrc36", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 36 isoform 3", "refseq_ac": "NP_001028543", "gene_names_uniprotkb": "Lrrc36", "gene_names_refseq": "Lrrc36", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 36", "protein_names_refseq": "leucine-rich repeat-containing protein 36 isoform 3; leucine-rich repeat-containing protein 36", "tax_id": 10090, "disease": "", "pathway": " (mmu:270091)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RX53", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3V0M2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSK8-1", "uniprot_id": "KS6B1_MOUSE", "mass": 59146.0, "length": 525, "protein_name": "Ribosomal protein S6 kinase beta-1", "gene_name": "Rps6kb1", "organism": "Mouse", "refseq_name": "ribosomal protein S6 kinase beta-1 isoform 1", "refseq_ac": "NP_001107806", "gene_names_uniprotkb": "Rps6kb1", "gene_names_refseq": "2610318I15Rik; P70S6K1; Rps6kb1; S6K-beta-1; S6K1; S6K; p70 S6K-alpha; p70 S6KA; p70-S6K 1; p70/85s6k; p70s6k", "protein_names_uniprotkb": "Ribosomal protein S6 kinase beta-1; 2.7.11.1; 70 kDa ribosomal protein S6 kinase 1; P70S6K1; Ribosomal protein S6 kinase I; S6K-beta-1; S6K1; S6K; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA; p70 ribosomal S6 kinase alpha; p70-S6K 1", "protein_names_refseq": "70 kDa ribosomal protein S6 kinase 1; p70 S6 kinase alpha; p70 ribosomal S6 kinase alpha; ribosomal protein S6 kinase I; ribosomal protein S6 kinase beta-1 isoform 1; ribosomal protein S6 kinase beta-1; ribosomal protein S6 kinase, 70kD, polypeptide 1; ribosomal protein S6 kinase, polypeptide 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); hyperinsulinism (Disease Ontology:DOID:2018); colon cancer (Disease Ontology:DOID:219); glucose metabolism disease (Disease Ontology:DOID:4194); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:72508); (R-MMU-166208)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11493700;11500364;12782654;15060135;17510057;18952604;21183079;21750661;24161930;28178239;31219806;32601203;34428180", "class_list": "", "function": "Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11493700, PubMed:11500364, PubMed:15060135, PubMed:24161930). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11493700, PubMed:11500364). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (By similarity). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (By similarity). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (By similarity). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (By similarity). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (By similarity). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:24161930). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (By similarity). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (PubMed:11493700). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (By similarity). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (By similarity). Mediates TNF-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (By similarity). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (By similarity). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SWG1;Q8CHX0", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.20;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;5.2.1.8;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0031670 cellular response to nutrient;GO:0000045 autophagosome assembly;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BSK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDN9-1", "uniprot_id": "LRRC9_MOUSE", "mass": 167302.0, "length": 1456, "protein_name": "Leucine-rich repeat-containing protein 9", "gene_name": "Lrrc9", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 9 isoform 1", "refseq_ac": "NP_001136200", "gene_names_uniprotkb": "Lrrc9", "gene_names_refseq": "4921529O18Rik; 4930432K16Rik; Lrrc9", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 9", "protein_names_refseq": "leucine-rich repeat-containing protein 9 isoform 1; leucine-rich repeat-containing protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:78257)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15592455;21750661;30084848;31599954", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CAD3;Q9D2J8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CDN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TY92-1", "uniprot_id": "MBD6_MOUSE", "mass": 100990.0, "length": 1003, "protein_name": "Methyl-CpG-binding domain protein 6", "gene_name": "Mbd6", "organism": "Mouse", "refseq_name": "methyl-CpG-binding domain protein 6 isoform 2", "refseq_ac": "NP_001334100", "gene_names_uniprotkb": "Mbd6", "gene_names_refseq": "D10Wsu93e; Mbd6", "protein_names_uniprotkb": "Methyl-CpG-binding domain protein 6; Methyl-CpG-binding protein MBD6", "protein_names_refseq": "methyl-CpG-binding domain protein 6 isoform 2; methyl-CpG-binding protein MBD6", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:110962); (R-MMU-5689603)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20700456;21750661;34428180", "class_list": "", "function": "Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. Heterochromatin recruitment is not mediated by DNA methylation. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability; may promote cancer cell growth., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PWH8", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005694 chromosome;GO:0010369 chromocenter", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TY92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZB0-1", "uniprot_id": "LRCC1_MOUSE", "mass": 119169.0, "length": 1026, "protein_name": "Leucine-rich repeat and coiled-coil domain-containing protein 1", "gene_name": "Lrrcc1", "organism": "Mouse", "refseq_name": "leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 1", "refseq_ac": "NP_001157051", "gene_names_uniprotkb": "Lrrcc1; Kiaa1764", "gene_names_refseq": "1200008A14Rik; 4932441F23Rik; Lrrcc1", "protein_names_uniprotkb": "Leucine-rich repeat and coiled-coil domain-containing protein 1", "protein_names_refseq": "leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 1; leucine-rich repeat and coiled-coil domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71710)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16479539;21750661;22872234;25428506;31219806;34428180;36210013", "class_list": "", "function": "Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RS58;Q4FZD6;Q6P8L1;Q9CUE1;Q9DC06", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole", "go_biological_process": "GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q69ZB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI18-1", "uniprot_id": "LRP1B_MOUSE", "mass": 513634.0, "length": 4599, "protein_name": "Low-density lipoprotein receptor-related protein 1B", "gene_name": "Lrp1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lrp1b; Lrpdit", "gene_names_refseq": "", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 1B; LRP-1B; LRP-DIT; Low-density lipoprotein receptor-related protein-deleted in tumor", "protein_names_refseq": "", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); epilepsy (Disease Ontology:DOID:1826); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:94217)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30899004;33300544;34418053;34428180;35820727;36084651;40885482", "class_list": "", "function": "Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 34, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 34, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 34, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 34, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 33, "disease_count": 12, "glyco_site_count": 50, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZD3;Q8BZM7", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005041 low-density lipoprotein particle receptor activity;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006897 endocytosis;GO:0014910 regulation of smooth muscle cell migration;GO:0032376 positive regulation of cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 8.2, "record_id": "Q9JI18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNC4-1", "uniprot_id": "LC7L2_MOUSE", "mass": 46583.0, "length": 392, "protein_name": "Putative RNA-binding protein Luc7-like 2", "gene_name": "Luc7l2", "organism": "Mouse", "refseq_name": "putative RNA-binding protein Luc7-like 2 isoform 3", "refseq_ac": "NP_001164320", "gene_names_uniprotkb": "Luc7l2", "gene_names_refseq": "4930471C18Rik; CGI59; Cgi74; Luc7l2", "protein_names_uniprotkb": "Putative RNA-binding protein Luc7-like 2; CGI-74 homolog", "protein_names_refseq": "CGI-74-like SR-rich; putative RNA-binding protein Luc7-like 2 isoform 3; putative RNA-binding protein Luc7-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:192196)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17656373;21183079;21750661;34428180;36288343;39627609", "class_list": "", "function": "May bind to RNA via its Arg/Ser-rich domain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99LM5;Q99PC3", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0016607 nuclear speck;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0006376 mRNA splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TNC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR64-1", "uniprot_id": "KISHA_MOUSE", "mass": 8074.0, "length": 72, "protein_name": "Protein kish-A", "gene_name": "Tmem167a; Tmem167", "organism": "Mouse", "refseq_name": "protein kish-A precursor", "refseq_ac": "NP_079611", "gene_names_uniprotkb": "Tmem167a; Tmem167; Tmem167", "gene_names_refseq": "0610041E09Rik; 5730424F14Rik; Gm10085; Tmem167a; Tmem167", "protein_names_uniprotkb": "Protein kish-A; Transmembrane protein 167A; Transmembrane protein 167", "protein_names_refseq": "protein kish-A precursor; protein kish-A; transmembrane protein 167A", "tax_id": 10090, "disease": "", "pathway": " (mmu:66074)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18299400;20173027;21750661;22872234;33649389;34203471;34428180;35820727", "class_list": "", "function": "Involved in the early part of the secretory pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3W3;Q9CZU1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0045054 constitutive secretory pathway;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CR64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q587J6-1", "uniprot_id": "LITD1_MOUSE", "mass": 88189.0, "length": 782, "protein_name": "LINE-1 type transposase domain-containing protein 1", "gene_name": "L1td1", "organism": "Mouse", "refseq_name": "LINE-1 type transposase domain-containing protein 1 isoform 2", "refseq_ac": "NP_001074671", "gene_names_uniprotkb": "L1td1; Ecat11", "gene_names_refseq": "ECAT11; L1td1", "protein_names_uniprotkb": "LINE-1 type transposase domain-containing protein 1; ES cell-associated protein 11", "protein_names_refseq": "ES cell-associated protein 11; LINE-1 type transposase domain-containing protein 1 isoform 2; LINE-1 type transposase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:381591)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21637830;21750661;32387751;34618297;34669125;41298451", "class_list": "", "function": "Inhibition of LINE-1 retrotransposition represses telomere reprogramming during mouse 2-cell embryo development., [RefSeq, PubMed]; LINE-1 specific nuclear organization in mice olfactory sensory neurons., [RefSeq, PubMed]; RNA-binding protein which plays a role in the regulation of pluripotency (PubMed:41298451). Preferentially binds to 5'-GAGCGU-3' sequences (PubMed:41298451). Binds to the 3'-UTR of the pluripotency regulator TFCP2L1, stabilizing transcripts and resulting in increased TFCP2L1 mRNA levels (PubMed:41298451)., [UniProtKB, PubMed]; These data demonstrate the dispensability of ECAT11/L1td1 in pluripotency, despite its specific expression., [RefSeq, PubMed]; Zidovudine inhibits telomere elongation, increases the transposable element LINE-1 copy number and compromises mouse embryo development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKY3", "ec_number_list": "", "go_molecular_function": "GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032197 retrotransposition", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q587J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1Q4-1", "uniprot_id": "LY66C_MOUSE", "mass": 14066.0, "length": 126, "protein_name": "Lymphocyte antigen 6 complex locus protein G6c", "gene_name": "Ly6g6c", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6 complex locus protein G6c precursor", "refseq_ac": "NP_075952", "gene_names_uniprotkb": "Ly6g6c; Ng24", "gene_names_refseq": "1110003M04Rik; G6c; Ly6g6c; NG24", "protein_names_uniprotkb": "Lymphocyte antigen 6 complex locus protein G6c", "protein_names_refseq": "lymphocyte antigen 6 complex G6C; lymphocyte antigen 6 complex locus protein G6c precursor; lymphocyte antigen 6 complex locus protein G6c; lymphocyte antigen 6 complex, locus G6C", "tax_id": 10090, "disease": "", "pathway": " (mmu:68468); (R-MMU-163125)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14656967;16170054;17008713;21750661;30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032991 protein-containing complex;GO:0098552 side of membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z1Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2Q2-1", "uniprot_id": "KNOP1_MOUSE", "mass": 53846.0, "length": 478, "protein_name": "Lysine-rich nucleolar protein 1", "gene_name": "Knop1", "organism": "Mouse", "refseq_name": "lysine-rich nucleolar protein 1 isoform 2", "refseq_ac": "NP_001161692", "gene_names_uniprotkb": "Knop1; 2310008H09Rik; Tsg118", "gene_names_refseq": "2310008H09Rik; Knop1; Tsg118", "protein_names_uniprotkb": "Lysine-rich nucleolar protein 1; Testis-specific gene 118 protein", "protein_names_refseq": "lysine-rich nucleolar protein 1 isoform 2; protein C16orf88 homolog; testis-specific gene 118 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66356)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10430019;15833274;21183079;21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKK6;Q7TMJ4;Q8BJI0;Q9D7H7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z2Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3L0-1", "uniprot_id": "MMGT2_MOUSE", "mass": 13922.0, "length": 123, "protein_name": "Membrane magnesium transporter 2", "gene_name": "Mmgt2", "organism": "Mouse", "refseq_name": "membrane magnesium transporter 2", "refseq_ac": "NP_778167", "gene_names_uniprotkb": "Mmgt2", "gene_names_refseq": "Mmgt2", "protein_names_uniprotkb": "Membrane magnesium transporter 2", "protein_names_refseq": "membrane magnesium transporter 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:216829)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;18057121;21750661", "class_list": "", "function": "Mediates Mg(2+) transport., [UniProtKB, PubMed]; These experiments suggest that MMgT proteins may provide regulated pathways for Mg(2+) transport in the Golgi and post-Golgi organelles of epithelium-derived cells.(MMgT1 PROTEIN, MOUSE), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005375 copper ion transmembrane transporter activity;GO:0005384 manganese ion transmembrane transporter activity;GO:0015087 cobalt ion transmembrane transporter activity;GO:0015099 nickel cation transmembrane transporter activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0015693 magnesium ion transport;GO:0006812 monoatomic cation transport;GO:0006825 copper ion transport;GO:0006828 manganese ion transport;GO:0015675 nickel cation transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R3L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VQ1-1", "uniprot_id": "LRRC1_MOUSE", "mass": 59412.0, "length": 524, "protein_name": "Leucine-rich repeat-containing protein 1", "gene_name": "Lrrc1", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 1 isoform 1", "refseq_ac": "NP_001139520", "gene_names_uniprotkb": "Lrrc1", "gene_names_refseq": "A430093J20Rik; D030059I21; Lrrc1; mKIAA4018", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 1", "protein_names_refseq": "leucine-rich repeat-containing protein 1 isoform 1; leucine-rich repeat-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:214345); (R-MMU-9696270)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;25428506;34428180;38473980", "class_list": "", "function": "The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI50;Q8BKR1;Q8BUS9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80VQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDD9-1", "uniprot_id": "LRIF1_MOUSE", "mass": 82998.0, "length": 755, "protein_name": "Ligand-dependent nuclear receptor-interacting factor 1", "gene_name": "Lrif1", "organism": "Mouse", "refseq_name": "ligand-dependent nuclear receptor-interacting factor 1 isoform 1", "refseq_ac": "NP_001034577", "gene_names_uniprotkb": "Lrif1; 4933421E11Rik", "gene_names_refseq": "2010012G17Rik; 4933421E11Rik; Lrif1", "protein_names_uniprotkb": "Ligand-dependent nuclear receptor-interacting factor 1", "protein_names_refseq": "ligand-dependent nuclear receptor-interacting factor 1 isoform 1", "tax_id": 10090, "disease": "facioscapulohumeral muscular dystrophy 3 (Disease Ontology:DOID:0060917)", "pathway": " (mmu:321000)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "19224205;20173027;21750661;25428506;26391951;30084848;30779550;31219806;34428180;35820727;36210013;36852467", "class_list": "", "function": "Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin. Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q149J0;Q8C893", "ec_number_list": "", "go_molecular_function": "GO:0042974 nuclear retinoic acid receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016363 nuclear matrix;GO:0034451 centriolar satellite;GO:0000781 chromosome, telomeric region;GO:0001740 Barr body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0009048 dosage compensation by inactivation of X chromosome", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CDD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61595-1", "uniprot_id": "KTN1_MOUSE", "mass": 152592.0, "length": 1327, "protein_name": "Kinectin", "gene_name": "Ktn1", "organism": "Mouse", "refseq_name": "kinectin isoform 2", "refseq_ac": "NP_001280564", "gene_names_uniprotkb": "Ktn1", "gene_names_refseq": "Ktn1", "protein_names_uniprotkb": "Kinectin", "protein_names_refseq": "kinectin isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16709); (R-MMU-381426); (R-MMU-5625970); (R-MMU-8957275); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013408); (R-MMU-9696264); (R-MMU-9696270)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15316074;21750661;28528544;34418053;34428180;34887587;36210013;36288343;8912005", "class_list": "", "function": "Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG49;Q8BHF4;Q8BHM8;Q8C9Y5;Q8CG51;Q8CG52;Q8CG53;Q8CG54;Q8CG55;Q8CG56;Q8CG57;Q8CG58;Q8CG59;Q8CG60;Q8CG61;Q8CG62;Q8CG63", "ec_number_list": "", "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q61595-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D956-1", "uniprot_id": "MALD3_MOUSE", "mass": 42146.0, "length": 376, "protein_name": "MARVEL domain-containing protein 3", "gene_name": "Marveld3", "organism": "Mouse", "refseq_name": "MARVEL domain-containing protein 3 isoform a", "refseq_ac": "NP_082860", "gene_names_uniprotkb": "Marveld3", "gene_names_refseq": "1810006A16Rik; Marvd3; Marveld3; Mrvldc3", "protein_names_uniprotkb": "MARVEL domain-containing protein 3", "protein_names_refseq": "MARVEL domain-containing protein 3 isoform a; MARVEL domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:73608)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20028514;20164257;21750661;34267243;35563847", "class_list": "", "function": "As a component of tight junctions, plays a role in paracellular ion conductivity., [UniProtKB]; MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating Effects during Colitis Indirectly Stabilizing the Intestinal Barrier. Publication Status: Online-Only, [RefSeq, PubMed]; MarvelD3, occludin, and tricellulin define the tight junction-associated MARVEL protein family, [RefSeq, PubMed]; Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R109", "ec_number_list": "", "go_molecular_function": "GO:0031435 mitogen-activated protein kinase kinase kinase binding", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0006970 response to osmotic stress;GO:0050680 negative regulation of epithelial cell proliferation;GO:0070830 bicellular tight junction assembly;GO:0046329 negative regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D956-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YK0-1", "uniprot_id": "LRC49_MOUSE", "mass": 78876.0, "length": 686, "protein_name": "Leucine-rich repeat-containing protein 49", "gene_name": "Lrrc49", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 49 isoform 1", "refseq_ac": "NP_001139518", "gene_names_uniprotkb": "Lrrc49", "gene_names_refseq": "D430025H09Rik; Lrrc49; PGs4; p79", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 49; PGs4; Tubulin polyglutamylase complex subunit 4; p79", "protein_names_refseq": "leucine-rich repeat-containing protein 49 isoform 1; leucine-rich repeat-containing protein 49; tubulin polyglutamylase complex subunit 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:102747)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;15890843;21750661;38348636", "class_list": "", "function": "Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy., [RefSeq, PubMed]; Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C3S4;Q8C7T7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0034451 centriolar satellite", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0000226 microtubule cytoskeleton organization;GO:0061523 cilium disassembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91YK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1M4-1", "uniprot_id": "KS6B2_MOUSE", "mass": 53538.0, "length": 485, "protein_name": "Ribosomal protein S6 kinase beta-2", "gene_name": "Rps6kb2", "organism": "Mouse", "refseq_name": "ribosomal protein S6 kinase beta-2", "refseq_ac": "NP_067460", "gene_names_uniprotkb": "Rps6kb2", "gene_names_refseq": "Rps6kb2; S6K-beta-2; S6K2", "protein_names_uniprotkb": "Ribosomal protein S6 kinase beta-2; 2.7.11.1; 70 kDa ribosomal protein S6 kinase 2; S6K-beta-2; S6K2; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; p70 ribosomal S6 kinase beta", "protein_names_refseq": "70 kDa ribosomal protein S6 kinase 2; S6 kinase 2; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; p70 ribosomal S6 kinase beta; ribosomal protein S6 kinase beta-2; ribosomal protein S6 kinase, 70kD, polypeptide 2; ribosomal protein S6 kinase, polypeptide 2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); glucose metabolism disease (Disease Ontology:DOID:4194); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:58988); (R-MMU-198693)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15060135;16204634;17242355;21750661;9822608", "class_list": "", "function": "Data show that the absence of ribosomal protein S6 kinases 1 and 2 (S6K1 and S6K2) profoundly impairs animal viability but does not seem to affect the proliferative responses of cells derived from the distinct S6K genotypes., [RefSeq, PubMed]; Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; S6K2 is activated by IL-3 in the IL-3-dependent Ba/F3 cell line and this is mediated by mTOR and its upstream activator PI-3K but not by MAPK signal pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042277 peptide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006468 protein phosphorylation;GO:0031929 TOR signaling;GO:0038202 TORC1 signaling;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z1M4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K5B2-1", "uniprot_id": "MCFD2_MOUSE", "mass": 16168.0, "length": 145, "protein_name": "Multiple coagulation factor deficiency protein 2 homolog", "gene_name": "Mcfd2", "organism": "Mouse", "refseq_name": "multiple coagulation factor deficiency protein 2 homolog precursor", "refseq_ac": "NP_647456", "gene_names_uniprotkb": "Mcfd2; Sdnsf", "gene_names_refseq": "1810021C21Rik; F5f8d; Lman1ip; Mcfd2; Sdnsf", "protein_names_uniprotkb": "Multiple coagulation factor deficiency protein 2 homolog; Neural stem cell-derived neuronal survival protein", "protein_names_refseq": "multiple coagulation factor deficiency protein 2 homolog precursor; multiple coagulation factor deficiency protein 2 homolog; neural stem cell derived neuronal survival protein", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:193813); (R-MMU-204005); (R-MMU-5694530)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16899390;21750661;25428506;29735583;34428180", "class_list": "", "function": "MCFD2-deficient mice generated by gene targeting also demonstrate reduced plasma FV and FVIII, with levels lower than those in LMAN1-deficient mice, similar to previous observations in LMAN1- and MCDF2-deficient humans., [RefSeq, PubMed]; The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins., [UniProtKB]; These results indicate that increased levels of cargo receptor proteins might have a function either in the quality control of protein folding in the endoplasmic reticulum or in the homeostasis of the intermediate compartment and Golgi complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9G5", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0062137 cargo receptor complex", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0010467 gene expression;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K5B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SUF2-1", "uniprot_id": "LC7L3_MOUSE", "mass": 51450.0, "length": 432, "protein_name": "Luc7-like protein 3", "gene_name": "Luc7l3", "organism": "Mouse", "refseq_name": "luc7-like protein 3 isoform 1", "refseq_ac": "NP_080589", "gene_names_uniprotkb": "Luc7l3; Crop", "gene_names_refseq": "3300001P08Rik; Luc7a; Luc7l3", "protein_names_uniprotkb": "Luc7-like protein 3; Cisplatin resistance-associated-overexpressed protein", "protein_names_refseq": "cisplatin resistance-associated overexpressed protein; luc7-like protein 3 isoform 1; luc7-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67684); (R-MMU-72163)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17242355;21183079;21750661;31219806;34428180;34887587;36210013;39627609", "class_list": "", "function": "Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9D5;Q8BUJ5;Q921Z3;Q9CRS7;Q9CTY4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0008380 RNA splicing;GO:0006376 mRNA splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5SUF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CBY3-1", "uniprot_id": "LENG8_MOUSE", "mass": 86767.0, "length": 785, "protein_name": "Leukocyte receptor cluster member 8 homolog", "gene_name": "Leng8", "organism": "Mouse", "refseq_name": "leukocyte receptor cluster member 8 homolog isoform 2", "refseq_ac": "NP_766324", "gene_names_uniprotkb": "Leng8", "gene_names_refseq": "Leng8", "protein_names_uniprotkb": "Leukocyte receptor cluster member 8 homolog", "protein_names_refseq": "leukocyte receptor cluster member 8 homolog isoform 2; leukocyte receptor cluster member 8 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:232798)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;34418053;36852467", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCN4;Q8C3P0;Q8CGB8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CBY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3T9M1-1", "uniprot_id": "MFS2B_MOUSE", "mass": 52797.0, "length": 494, "protein_name": "Sphingosine-1-phosphate transporter MFSD2B", "gene_name": "Mfsd2b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mfsd2b; Gm1964", "gene_names_refseq": "", "protein_names_uniprotkb": "Sphingosine-1-phosphate transporter MFSD2B; Major facilitator superfamily domain-containing protein 2B; mMfsd2b", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:432628); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "18694395;21750661;29045386;29563527;30084848;33334894;33785361;33863882", "class_list": "", "function": "Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386, PubMed:29563527, PubMed:33334894, PubMed:33863882). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (PubMed:29045386). Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation (PubMed:33863882). Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate) (PubMed:33863882). Release of sphingosine-1-phosphate is facilitated by a proton gradient (PubMed:33334894). In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport (PubMed:29563527, PubMed:33334894). In addition to export, also able to mediate S1P import (PubMed:33785361). Does not transport lysophosphatidylcholine (LPC) (PubMed:29045386)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRN2;Q3U198", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0046624 sphingolipid transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0006869 lipid transport;GO:0055085 transmembrane transport;GO:0008643 carbohydrate transport;GO:1901731 positive regulation of platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3T9M1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VY5-1", "uniprot_id": "KDM4B_MOUSE", "mass": 121604.0, "length": 1086, "protein_name": "Lysine-specific demethylase 4B", "gene_name": "Kdm4b", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 4B isoform 1", "refseq_ac": "NP_742144", "gene_names_uniprotkb": "Kdm4b; Jhdm3b; Jmjd2b", "gene_names_refseq": "4732474L06Rik; Jmjd2b; Kdm4b", "protein_names_uniprotkb": "Lysine-specific demethylase 4B; 1.14.11.66; JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B; [histone H3]-trimethyl-L-lysine(9) demethylase 4B", "protein_names_refseq": "[histone H3]-trimethyl-L-lysine(9) demethylase 4B; jmjC domain-containing histone demethylation protein 3B; jumonji domain-containing protein 2B; lysine-specific demethylase 4B isoform 1; lysine-specific demethylase 4B", "tax_id": 10090, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); autosomal dominant intellectual developmental disorder 65 (Disease Ontology:DOID:0061038); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); malignant peripheral nerve sheath tumor (Disease Ontology:DOID:5940); colorectal cancer (Disease Ontology:DOID:9256); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:193796); (R-MMU-3214842); (R-MMU-5693565)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16738407;21750661;27023172;31219806;34428180;36773117;38950776", "class_list": "", "function": "A subgroup of murine Jmjd2 proteins antagonize H3K9me3 at pericentric heterochromatin., [RefSeq, PubMed]; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). Plays a critical role in the development of the central nervous system (CNS)., [UniProtKB, UniProtKB, PubMed]; Novel insights into the angiogenic function of JMJD2B in diabetic hind limb ischemia: involvement of activating Wnt/beta-catenin pathway., [RefSeq, PubMed]; Super-enhancer-driven LncRNA PPARalpha-seRNA exacerbates glucolipid metabolism and diabetic cardiomyopathy via recruiting KDM4B., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UR22;Q6ZQ30;Q99K42", "ec_number_list": "2.3.2.23;2.3.2.-;3.6.-.-;1.14.11.66;2.3.2.26;3.1.-.-;2.7.11.1;2.3.2.27;2.1.1.357;1.14.11.69;1.14.11.-;1.14.11.79;2.3.1.48;2.3.1.-", "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0008270 zinc ion binding;GO:0032452 histone demethylase activity;GO:0032454 histone H3K9 demethylase activity;GO:0140684 histone H3K9me2/H3K9me3 demethylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007420 brain development;GO:0010468 regulation of gene expression;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91VY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59178-1", "uniprot_id": "LMBL2_MOUSE", "mass": 78971.0, "length": 703, "protein_name": "Lethal(3)malignant brain tumor-like protein 2", "gene_name": "L3mbtl2", "organism": "Mouse", "refseq_name": "lethal(3)malignant brain tumor-like protein 2 isoform 2", "refseq_ac": "NP_666105", "gene_names_uniprotkb": "L3mbtl2", "gene_names_refseq": "4732493N06Rik; L3mbtl2; M4mbt", "protein_names_uniprotkb": "Lethal(3)malignant brain tumor-like protein 2; L(3)mbt-like protein 2", "protein_names_refseq": "l(3)mbt-like 2; l(3)mbt-like protein 2; lethal(3)malignant brain tumor-like protein 2 isoform 2; lethal(3)malignant brain tumor-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:214669); (R-MMU-4551638); (R-MMU-8953750)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "14597177;21750661;30760872;31219806", "class_list": "", "function": "L3MBTL2 regulates chromatin remodeling during spermatogenesis., [RefSeq, PubMed]; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHD5", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:1990841 promoter-specific chromatin binding;GO:0140005 histone H4K20me2 reader activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0048863 stem cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P59178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2T6-1", "uniprot_id": "KRT85_MOUSE", "mass": 55759.0, "length": 507, "protein_name": "Keratin, type II cuticular Hb5", "gene_name": "Krt85", "organism": "Mouse", "refseq_name": "keratin, type II cuticular Hb5", "refseq_ac": "NP_058575", "gene_names_uniprotkb": "Krt85; Gm49425; Krt2-18; Krthb5", "gene_names_refseq": "Gm49425; Hb5; K85; Krt2-18; Krt85", "protein_names_uniprotkb": "Keratin, type II cuticular Hb5; K85; Keratin-85; Type II hair keratin Hb5; Type-II keratin Kb25", "protein_names_refseq": "keratin complex 2, basic, gene 18; keratin, type II cuticular Hb5; type II hair keratin Hb5; type-II keratin Kb25", "tax_id": 10090, "disease": "ectodermal dysplasia 4 (Disease Ontology:DOID:0111658)", "pathway": " (mmu:53622); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;34428180;35984892", "class_list": "", "function": "Structural component of intermediate filaments in the hair follicle. As a type II hair keratin, participates in the formation of keratin intermediate filament networks by forming obligate heterodimers with type I hair keratins. Expressed at early stages of hair differentiation in matrix cells and later in cuticle-forming cells, where it contributes to the structural integrity and mechanical resilience of the hair shaft., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CE83;Q9D7M4", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z2T6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XQ6-1", "uniprot_id": "LAP4B_MOUSE", "mass": 25395.0, "length": 227, "protein_name": "Lysosomal-associated transmembrane protein 4B", "gene_name": "Laptm4b", "organism": "Mouse", "refseq_name": "lysosomal-associated transmembrane protein 4B", "refseq_ac": "NP_277056", "gene_names_uniprotkb": "Laptm4b", "gene_names_refseq": "C330023P13Rik; LAPTM4beta; Laptm4b", "protein_names_uniprotkb": "Lysosomal-associated transmembrane protein 4B", "protein_names_refseq": "lysosomal-associated transmembrane protein 4B; lysosomal-associated transmembrane protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:114128)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12902989;18250455;21750661;21913724;22096579;26495903;28011936;32693673;34428180;34627451;37828378", "class_list": "", "function": "A potential protooncogene whose overexpression is involved in carcinogenesis and progression of hepatocellular carcinoma, [RefSeq, PubMed]; Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury. Erratum:[Circ Res. 2023 Mar 3;132(5):e94. doi: 10.1161/RES.0000000000000597. PMID: 36862816], [RefSeq, PubMed]; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results suggest that while some requisites of LAPTM5 lysosomal sorting are conserved among LAPTM4 proteins, LAPTM4a and LAPTM4b have also developed distinct sorting requirements., [RefSeq, PubMed]; [Effect of Laptm4b Deletion on Hematopoietic Stem and Progenitor Cells Homeostasis in Mice]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0097001 ceramide binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0007032 endosome organization;GO:1905166 negative regulation of lysosomal protein catabolic process;GO:0032911 negative regulation of transforming growth factor beta1 production;GO:0032509 endosome transport via multivesicular body sorting pathway;GO:0097213 regulation of lysosomal membrane permeability", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91XQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUJ9-1", "uniprot_id": "LRP12_MOUSE", "mass": 94551.0, "length": 858, "protein_name": "Low-density lipoprotein receptor-related protein 12", "gene_name": "Lrp12", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor-related protein 12 isoform 2 precursor", "refseq_ac": "NP_001333965", "gene_names_uniprotkb": "Lrp12", "gene_names_refseq": "C820005L12Rik; LRP-12; Lrp12", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 12; LRP-12", "protein_names_refseq": "low-density lipoprotein receptor-related protein 12 isoform 2 precursor; low-density lipoprotein receptor-related protein 12", "tax_id": 10090, "disease": "oculopharyngodistal myopathy 1 (Disease Ontology:DOID:0081297); amyotrophic lateral sclerosis type 28 (Disease Ontology:DOID:0081382)", "pathway": " (mmu:239393); (R-MMU-975634)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;18250455;21750661;26495903;28011936;31599954;37330909;37828378", "class_list": "", "function": "LRP12 is an endogenous transmembrane inactivator of alpha4 integrins., [RefSeq, PubMed]; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWM9", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006897 endocytosis;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0031175 neuron projection development;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BUJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08746-1", "uniprot_id": "MATN2_MOUSE", "mass": 106748.0, "length": 956, "protein_name": "Matrilin-2", "gene_name": "Matn2", "organism": "Mouse", "refseq_name": "matrilin-2 isoform 1 precursor", "refseq_ac": "NP_001345709", "gene_names_uniprotkb": "Matn2", "gene_names_refseq": "Crtm2; Matn2; matrilin-2", "protein_names_uniprotkb": "Matrilin-2", "protein_names_refseq": "matrilin-2 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17181)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11852232;21750661;34428180;9083061", "class_list": "", "function": "Involved in matrix assembly., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QPK9;Q8R542", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0120216 matrilin complex;GO:0005576 extracellular region", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0031175 neuron projection development;GO:0001764 neuron migration;GO:0048678 response to axon injury;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08746-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVH9-1", "uniprot_id": "METL6_MOUSE", "mass": 32786.0, "length": 282, "protein_name": "tRNA N(3)-cytidine methyltransferase METTL6", "gene_name": "Mettl6", "organism": "Mouse", "refseq_name": "tRNA N(3)-cytidine methyltransferase METTL6 isoform 1", "refseq_ac": "NP_080183", "gene_names_uniprotkb": "Mettl6", "gene_names_refseq": "1600013P15Rik; Mettl6", "protein_names_uniprotkb": "tRNA N(3)-cytidine methyltransferase METTL6; 2.1.1.-; Methyltransferase-like protein 6", "protein_names_refseq": "methyltransferase like 6; methyltransferase-like protein 6; tRNA N(3)-cytidine methyltransferase METTL6 isoform 1; tRNA N(3)-cytidine methyltransferase METTL6; tRNA N(3)-methylcytidine methyltransferase METTL6", "tax_id": 10090, "disease": "", "pathway": " (mmu:67011)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28655767;32923617", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:28655767). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9M6;Q9DAX6", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0019899 enzyme binding;GO:0052735 tRNA (cytidine-3-)-methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043527 tRNA methyltransferase complex", "go_biological_process": "GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0106217 tRNA C3-cytosine methylation;GO:0008033 tRNA processing;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BVH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C181-1", "uniprot_id": "MBNL2_MOUSE", "mass": 40156.0, "length": 373, "protein_name": "Muscleblind-like protein 2", "gene_name": "Mbnl2", "organism": "Mouse", "refseq_name": "muscleblind-like protein 2 isoform 1", "refseq_ac": "NP_780550", "gene_names_uniprotkb": "Mbnl2; Kiaa4072", "gene_names_refseq": "1110002M11Rik; MBLL; Mbnl2; mKIAA4072", "protein_names_uniprotkb": "Muscleblind-like protein 2", "protein_names_refseq": "muscleblind-like 2; muscleblind-like protein 2 isoform 1; muscleblind-like protein 2", "tax_id": 10090, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonic disease (Disease Ontology:DOID:450)", "pathway": " (mmu:105559)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;38473933;40997131", "class_list": "", "function": "Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (By similarity). Regulates NCOR2 alternative splicing (By similarity). Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity)., [UniProtKB, UniProtKB]; Studying the Effect of MBNL1 and MBNL2 Loss in Skeletal Muscle Regeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPH4;Q5DTQ0;Q8BUD8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C181-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UL97-1", "uniprot_id": "MCAF2_MOUSE", "mass": 50975.0, "length": 452, "protein_name": "Activating transcription factor 7-interacting protein 2", "gene_name": "Atf7ip2", "organism": "Mouse", "refseq_name": "activating transcription factor 7-interacting protein 2 isoform 2", "refseq_ac": "NP_083529", "gene_names_uniprotkb": "Atf7ip2; Mcaf2; Psm2", "gene_names_refseq": "4930558K11Rik; Atf7ip2; Get-1; PSM2", "protein_names_uniprotkb": "Activating transcription factor 7-interacting protein 2; MBD1-containing chromatin-associated factor 2; Protein similar to MCAF2", "protein_names_refseq": "MBD1-containing chromatin-associated factor 2; activating transcription factor 7-interacting protein 2 isoform 2; protein similar to MCAF2", "tax_id": 10090, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:75329)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16850184;21750661;25428506;37542719", "class_list": "", "function": "ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis., [RefSeq, PubMed]; Cloning and characterization of PSM2; deduced protein has high similarity with human MCAF2; hypothesized that PSM2 might interact with some important partners by the conserved domain and be involved in the transcription modulation during gonad development, [RefSeq, PubMed]; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT16;Q4VIF3;Q8BPC5;Q9D4T8", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UL97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWJ3-1", "uniprot_id": "KPB2_MOUSE", "mass": 138492.0, "length": 1235, "protein_name": "Phosphorylase b kinase regulatory subunit alpha, liver isoform", "gene_name": "Phka2", "organism": "Mouse", "refseq_name": "phosphorylase b kinase regulatory subunit alpha, liver isoform isoform a", "refseq_ac": "NP_001171350", "gene_names_uniprotkb": "Phka2", "gene_names_refseq": "6330505C01Rik; D330034O08; Phka2; Phk", "protein_names_uniprotkb": "Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase kinase alpha L subunit", "protein_names_refseq": "phosphorylase b kinase regulatory subunit alpha, liver isoform isoform a; phosphorylase kinase alpha L subunit", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); glycogen storage disease IXa1 (Disease Ontology:DOID:0111042); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (mmu:110094); (R-MMU-70221)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17242355;21183079;21750661;25428506;30084848;31219806;34428180;35820727", "class_list": "", "function": "Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TN65;Q810J6", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005964 phosphorylase kinase complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BWJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61846-1", "uniprot_id": "MELK_MOUSE", "mass": 72729.0, "length": 643, "protein_name": "Maternal embryonic leucine zipper kinase", "gene_name": "Melk", "organism": "Mouse", "refseq_name": "maternal embryonic leucine zipper kinase isoform 1", "refseq_ac": "NP_034920", "gene_names_uniprotkb": "Melk; Kiaa0175; Pk38", "gene_names_refseq": "MPK38; Melk; mKIAA0175", "protein_names_uniprotkb": "Maternal embryonic leucine zipper kinase; 2.7.10.2; 2.7.11.1; Protein kinase PK38; Tyrosine-protein kinase MELK; mPK38", "protein_names_refseq": "maternal embryonic leucine zipper kinase isoform 1; protein kinase PK38; tyrosine-protein kinase MELK", "tax_id": 10090, "disease": "", "pathway": " (mmu:17279)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "16061694;17242355;18948261;19144319;21183079;21750661;24531485;25428506;28135057;30779550;31219806;33268463;34203471;34365141;34428180;35730614;36210013;9136115;9305775", "class_list": "", "function": "Ablation of AMPK-Related Kinase MPK38/MELK Leads to Male-Specific Obesity in Aged Mature Adult Mice., [RefSeq, PubMed]; DAXX ameliorates metabolic dysfunction in mice with diet-induced obesity by activating the AMP-activated protein kinase-related kinase MPK38/MELK., [RefSeq, PubMed]; MELK predicts poor prognosis and promotes metastasis in esophageal squamous cell carcinoma via activating the NFkappaB pathway., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPU1;Q61804;Q6ZQH6", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.10.1;2.7.12.1;2.7.11.22;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0046777 protein autophosphorylation;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q61846-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSH2-1", "uniprot_id": "KPBB_MOUSE", "mass": 123889.0, "length": 1085, "protein_name": "Phosphorylase b kinase regulatory subunit beta", "gene_name": "Phkb", "organism": "Mouse", "refseq_name": "phosphorylase b kinase regulatory subunit beta isoform 1", "refseq_ac": "NP_955517", "gene_names_uniprotkb": "Phkb", "gene_names_refseq": "Phkb", "protein_names_uniprotkb": "Phosphorylase b kinase regulatory subunit beta; Phosphorylase kinase subunit beta", "protein_names_refseq": "phosphorylase b kinase regulatory subunit beta isoform 1; phosphorylase b kinase regulatory subunit beta", "tax_id": 10090, "disease": "glycogen storage disease IXb (Disease Ontology:DOID:0111041)", "pathway": " (mmu:102093); (R-MMU-70221)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18549242;21183079;21750661;30084848;31219806;33300544;34428180;36077341;36210013;39927985", "class_list": "", "function": "A Mouse Model of Glycogen Storage Disease Type IX-Beta: A Role for Phkb in Glycogenolysis. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The interactions described herein between the beta subunit of PhK and GAPDH provide a possible mechanism for the direct linkage of glycogenolysis and glycolysis in skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005964 phosphorylase kinase complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0006468 protein phosphorylation;GO:0042593 glucose homeostasis;GO:0005980 glycogen catabolic process;GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q7TSH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U285-1", "uniprot_id": "LCORL_MOUSE", "mass": 66695.0, "length": 600, "protein_name": "Ligand-dependent nuclear receptor corepressor-like protein", "gene_name": "Lcorl", "organism": "Mouse", "refseq_name": "ligand-dependent nuclear receptor corepressor-like protein isoform 1", "refseq_ac": "NP_001156545", "gene_names_uniprotkb": "Lcorl; Mlr1", "gene_names_refseq": "Gm3414; Lcorl; Mlr1", "protein_names_uniprotkb": "Ligand-dependent nuclear receptor corepressor-like protein; LCoR-like protein; Mblk1-related protein 1; Transcription factor MLR1", "protein_names_refseq": "LCoR-like protein; Mblk1-related protein-1; ligand-dependent nuclear receptor corepressor-like protein isoform 1; ligand-dependent nuclear receptor corepressor-like protein; mblk1-related protein 1; transcription factor MLR1", "tax_id": 10090, "disease": "", "pathway": " (mmu:209707)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12560079;21750661;25366156", "class_list": "", "function": "Identification and characterization of Mlr2 a homolog of Mblk-1, a transcription factor from the honeybee brain; expressed predominantly in the spermatocytes of the testis, [RefSeq, PubMed]; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis., [UniProtKB, PubMed]; These findings suggest that transactivation activities of Mlr1 and Mlr2 are differentially regulated by splicing variants of NOL4, which are expressed in a tissue-selective manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRS7;Q6NZG1;Q8BNH5;Q8BRN7;Q8BRT8;Q8C9J6;Q8CJG4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:1990226 histone methyltransferase binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3U285-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH31-1", "uniprot_id": "MFSD8_MOUSE", "mass": 57569.0, "length": 519, "protein_name": "Major facilitator superfamily domain-containing protein 8", "gene_name": "Mfsd8", "organism": "Mouse", "refseq_name": "major facilitator superfamily domain-containing protein 8", "refseq_ac": "NP_082416", "gene_names_uniprotkb": "Mfsd8", "gene_names_refseq": "2810423E13Rik; Cln7; Mfsd8", "protein_names_uniprotkb": "Major facilitator superfamily domain-containing protein 8", "protein_names_refseq": "major facilitator superfamily domain-containing protein 8", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis 7 (Disease Ontology:DOID:0110722)", "pathway": " (mmu:72175)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;26681805;31219806;34428180;34910516;35087090;36210013", "class_list": "", "function": "Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis. Publication Status: Online-Only, [RefSeq, PubMed]; Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions., [UniProtKB, PubMed, UniProtKB]; We have disrupted the Cln7/Mfsd8 gene in mice by targeted deletion of exon 2 generating a novel knockout (KO) mouse model for CLN7 disease, which recapitulates key features of human CLN7 disease pathology., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91VS1;Q9CZ06", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0005254 chloride channel activity;GO:0015111 iodide transmembrane transporter activity;GO:0062054 fluoride channel activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0048708 astrocyte differentiation;GO:0006664 glycolipid metabolic process;GO:0010506 regulation of autophagy;GO:0050905 neuromuscular process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BH31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UPL6-1", "uniprot_id": "M4A15_MOUSE", "mass": 25941.0, "length": 245, "protein_name": "Membrane-spanning 4-domains subfamily A member 15", "gene_name": "Ms4a15", "organism": "Mouse", "refseq_name": "membrane-spanning 4-domains subfamily A member 15 isoform 1", "refseq_ac": "NP_001030070", "gene_names_uniprotkb": "Ms4a15", "gene_names_refseq": "E530011F12Rik; Gm1286; Ms4a15", "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 15", "protein_names_refseq": "membrane-spanning 4-domains subfamily A member 15 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:545279)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in signal transduction as a component of a multimeric receptor complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RVI3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UPL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35711-1", "uniprot_id": "LIPB2_MOUSE", "mass": 98753.0, "length": 882, "protein_name": "Liprin-beta-2", "gene_name": "Ppfibp2", "organism": "Mouse", "refseq_name": "liprin-beta-2 isoform 2", "refseq_ac": "NP_001157029", "gene_names_uniprotkb": "Ppfibp2; Cclp1", "gene_names_refseq": "Cclp1; Ppfibp2", "protein_names_uniprotkb": "Liprin-beta-2; Coiled-coil-like protein 1; PTPRF-interacting protein-binding protein 2; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2", "protein_names_refseq": "PTPRF-interacting protein-binding protein 2; coiled-coil-like protein 1; liprin-beta-2 isoform 2; liprin-beta-2; protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2; protein tyrosine phosphatase, receptor-type, F interacting protein, binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19024); (R-MMU-388844)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;31219806;34428180;9199242", "class_list": "", "function": "May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9737, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q497W6;Q7TMG4;Q8CBS6;Q99KX6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0048786 presynaptic active zone;GO:0098793 presynapse", "go_biological_process": "GO:0007528 neuromuscular junction development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O35711-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVL9-1", "uniprot_id": "JKIP1_MOUSE", "mass": 73139.0, "length": 626, "protein_name": "Janus kinase and microtubule-interacting protein 1", "gene_name": "Jakmip1", "organism": "Mouse", "refseq_name": "janus kinase and microtubule-interacting protein 1 isoform 2", "refseq_ac": "NP_848481", "gene_names_uniprotkb": "Jakmip1; Gababrbp; Marlin1", "gene_names_refseq": "5830437M04Rik; C330021K24Rik; Gababrbp; Jakmip1; Marlin-1", "protein_names_uniprotkb": "Janus kinase and microtubule-interacting protein 1; GABA-B receptor-binding protein; Marlin-1; Multiple alpha-helices and RNA-linker protein 1", "protein_names_refseq": "GABA-B receptor-binding protein; gamma-aminobutyric acid (GABA-B) receptor binding protein; janus kinase and microtubule-interacting protein 1 isoform 2; multiple alpha-helices and RNA-linker protein 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:76071)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14718537;17532644;19386132;21183079;21750661;26627310;34428180", "class_list": "", "function": "Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements., [UniProtKB, PubMed]; JAKMIP1 loss dysregulates neuronal translation during synaptic development and results in social deficits and other autistic-like behaviors., [RefSeq, PubMed]; Marlin-1 is enriched in restricted areas of the brain including olfactory bulb, cerebral cortex, hippocampus and cerebellum; it is abundant in dendrites and axons of hippocampal neurons, associated with microtubules at the ultrastructural level. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RS01", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008017 microtubule binding;GO:0019900 kinase binding;GO:0019894 kinesin binding;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0005874 microtubule;GO:0016020 membrane;GO:0015630 microtubule cytoskeleton;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0015031 protein transport;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BVL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AA28-1", "uniprot_id": "MET23_MOUSE", "mass": 28289.0, "length": 253, "protein_name": "Histone-arginine methyltransferase METTL23", "gene_name": "Mettl23", "organism": "Mouse", "refseq_name": "histone-arginine methyltransferase METTL23", "refseq_ac": "NP_083141", "gene_names_uniprotkb": "Mettl23; 1110005A03Rik", "gene_names_refseq": "1110005A03Rik; 1500035B17Rik; 4933424L15Rik; Mettl23", "protein_names_uniprotkb": "Histone-arginine methyltransferase METTL23; 2.1.1.319; Methyltransferase-like protein 23", "protein_names_refseq": "histone-arginine methyltransferase METTL23; methyltransferase-like protein 23; probable methyltransferase-like protein 23", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 44 (Disease Ontology:DOID:0081208); glaucoma (Disease Ontology:DOID:1686)", "pathway": " (mmu:74319)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18564434;21750661;25428506;28930672;36099048", "class_list": "", "function": "Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (PubMed:28930672). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (PubMed:28930672)., [UniProtKB, PubMed]; Located immediately downstream of Jmjd6, with a bi-directionar promoter between the two. Publication Status: Online-Only, [RefSeq, PubMed]; METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2Z2;Q9D1J5", "ec_number_list": "2.1.1.319;1.14.11.80", "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0042054 histone methyltransferase activity;GO:0035642 histone H3R17 methyltransferase activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001939 female pronucleus;GO:0001940 male pronucleus", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050890 cognition;GO:0032259 methylation;GO:0040029 epigenetic regulation of gene expression;GO:0044727 epigenetic programing of male pronucleus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2AA28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIV3-1", "uniprot_id": "LIPH_MOUSE", "mass": 50675.0, "length": 451, "protein_name": "Lipase member H", "gene_name": "Liph", "organism": "Mouse", "refseq_name": "lipase member H isoform 1 precursor", "refseq_ac": "NP_001077363", "gene_names_uniprotkb": "Liph", "gene_names_refseq": "C130037N08Rik; D16Wsu119e; H06; Liph; Lpdlr; P3; PLA1B; lpd1; lpd2; mPA-PLA1", "protein_names_uniprotkb": "Lipase member H; 3.1.1.-", "protein_names_refseq": "lipase member H isoform 1 precursor; lipase, member H", "tax_id": 10090, "disease": "hypotrichosis 7 (Disease Ontology:DOID:0110704)", "pathway": " (mmu:239759); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12213196;21750661;23677168;30084848", "class_list": "", "function": "Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid (By similarity). Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; We finally isolate control and Enpp2-null dermal pipilla precursors and identify the expression and upregulation of LIPH, an alternative LPA-producing enzyme, suggesting that this gene could functionally compensate for the absence of Enpp2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRT3;Q3TTZ0;Q3UWA2;Q8BXB5;Q8CI45", "ec_number_list": "3.1.1.-;3.1.1.3;3.1.1.32;3.1.1.111;3.1.1.118", "go_molecular_function": "GO:0008201 heparin binding;GO:0052689 carboxylic ester hydrolase activity;GO:0004620 phospholipase activity;GO:0016298 lipase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CIV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UY51-1", "uniprot_id": "LRC55_MOUSE", "mass": 33030.0, "length": 298, "protein_name": "Leucine-rich repeat-containing protein 55", "gene_name": "Lrrc55", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 55 precursor", "refseq_ac": "NP_001028518", "gene_names_uniprotkb": "Lrrc55; Gm351", "gene_names_refseq": "A330097E02Rik; Gm351; Lrrc55", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 55; BK channel auxiliary gamma subunit LRRC55", "protein_names_refseq": "BK channel auxiliary gamma subunit LRRC55; BK channel auxilliary gamma subunit LRRC55; leucine-rich repeat-containing protein 55 precursor; leucine-rich repeat-containing protein 55", "tax_id": 10090, "disease": "", "pathway": " (mmu:241528)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;29370300;30899004;31213650;31526288;33346797", "class_list": "", "function": "Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation., [RefSeq, PubMed]; LRRC55 mRNA is richly expressed in the adult mouse medial habenula nucleus (MHb), cerebellum and pons. However, the potential role of LRRC55 in MHb and cerebellum could be different based on the function of BK channels in these brain regions Erratum:[PLoS One. 2018 May 10;13(5):e0197531. doi: 10.1371/journal.pone.0197531. PMID: 29746565] Publication Status: Online-Only, [RefSeq, PubMed]; Lrrc55 is a novel prosurvival factor that is upregulated specifically in islets during pregnancy, and it prevents conversion of adaptive unfolded protein response to unresolved ER stress and apoptosis in beta-cells, [RefSeq, PubMed]; Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity;GO:0099104 potassium channel activator activity", "go_cellular_component": "GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1903818 positive regulation of voltage-gated potassium channel activity;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3UY51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHA1-1", "uniprot_id": "LRC24_MOUSE", "mass": 56334.0, "length": 521, "protein_name": "Leucine-rich repeat-containing protein 24", "gene_name": "Lrrc24", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 24 precursor", "refseq_ac": "NP_932787", "gene_names_uniprotkb": "Lrrc24", "gene_names_refseq": "6430402H13Rik; Lrrc24", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 24", "protein_names_refseq": "leucine-rich repeat-containing protein 24 precursor; leucine-rich repeat-containing protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:378937)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;25428506;30899004", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q14AD4", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BHA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHB3-1", "uniprot_id": "LAX1_MOUSE", "mass": 44838.0, "length": 407, "protein_name": "Lymphocyte transmembrane adapter 1", "gene_name": "Lax1", "organism": "Mouse", "refseq_name": "lymphocyte transmembrane adapter 1", "refseq_ac": "NP_001153121", "gene_names_uniprotkb": "Lax1; Lax", "gene_names_refseq": "A530029E09; E430019B13Rik; Lax1", "protein_names_uniprotkb": "Lymphocyte transmembrane adapter 1; Linker for activation of X cells; Membrane-associated adapter protein LAX", "protein_names_refseq": "linker for activation of X cells; lymphocyte transmembrane adapter 1; membrane-associated adapter protein LAX", "tax_id": 10090, "disease": "", "pathway": " (mmu:240754)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12359715;15843560;16672218;21750661;23307938;26495903;28011936", "class_list": "", "function": "LAX negatively regulates mast cell function, [RefSeq, PubMed]; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells., [UniProtKB, PubMed]; SIT and LAX are important negative regulators of immune responses that functionally cooperate., [RefSeq, PubMed]; Upon T or B cell activation, the LAX protein is up-regulated dramatically. This in vivo study of LAX-deficient mice demonstrates that LAX functions as a negative regulator in lymphocyte signaling., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BS18;Q8CGV1", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0046649 lymphocyte activation;GO:0006955 immune response;GO:0035556 intracellular signal transduction;GO:0042113 B cell activation;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BHB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K419-1", "uniprot_id": "LEG4_MOUSE", "mass": 36372.0, "length": 326, "protein_name": "Galectin-4", "gene_name": "Lgals4", "organism": "Mouse", "refseq_name": "galectin-4 isoform 1", "refseq_ac": "NP_034836", "gene_names_uniprotkb": "Lgals4", "gene_names_refseq": "Lgals4; gal-4", "protein_names_uniprotkb": "Galectin-4; Gal-4; Lactose-binding lectin 4", "protein_names_refseq": "galectin-4 isoform 1; galectin-4; lactose-binding lectin 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:16855)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21358051;21750661;34428180;36359880;36478037;36529516;9446608", "class_list": "glycogene", "function": "Enhancement of Vivid-based photo-activatable Gal4 transcription factor in mammalian cells., [RefSeq, PubMed]; Extracellular Galectin 4 Drives Immune Evasion and Promotes T-cell Apoptosis in Pancreatic Cancer., [RefSeq, PubMed]; Galectin that binds lactose and a related range of sugars., [UniProtKB]; Normal Cortical Myelination in Galectin-4-Deficient Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 51, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88353;Q91X74", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0016936 galactoside binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0002780 antibacterial peptide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K419-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RL79-1", "uniprot_id": "KTAP2_MOUSE", "mass": 14675.0, "length": 136, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2", "gene_name": "Krtcap2", "organism": "Mouse", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 isoform 1", "refseq_ac": "NP_079603", "gene_names_uniprotkb": "Krtcap2", "gene_names_refseq": "0610010I12Rik; Kcp2; Krtcap2", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2; KCP-2; Keratinocyte-associated protein 2; Oligosaccharyl transferase subunit KCP2", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 isoform 1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2; oligosaccharyl transferase subunit KCP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66059)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;21768116;25428507;25605945;34428180", "class_list": "", "function": "Components of the oligosaccharyltransferase complex DC2 and KCP2 can interact with the gamma-secretase and affect the amyloid precursor protein processing pathway., [RefSeq, PubMed]; Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQK5", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A;GO:0016020 membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5RL79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2D9-1", "uniprot_id": "KLD8B_MOUSE", "mass": 37592.0, "length": 354, "protein_name": "Kelch domain-containing protein 8B", "gene_name": "Klhdc8b", "organism": "Mouse", "refseq_name": "kelch domain-containing protein 8B", "refseq_ac": "NP_084351", "gene_names_uniprotkb": "Klhdc8b", "gene_names_refseq": "4931406O17Rik; Klhdc8b", "protein_names_uniprotkb": "Kelch domain-containing protein 8B", "protein_names_refseq": "kelch domain-containing protein 8B", "tax_id": 10090, "disease": "Hodgkin's lymphoma (Disease Ontology:DOID:8567)", "pathway": " (mmu:78267)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18250455;21750661", "class_list": "", "function": "Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045171 intercellular bridge;GO:0030496 midbody;GO:0110070 cellularization cleavage furrow", "go_biological_process": "GO:1902410 mitotic cytokinetic process;GO:0140014 mitotic nuclear division;GO:0098813 nuclear chromosome segregation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D2D9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUL5-1", "uniprot_id": "KLHL7_MOUSE", "mass": 65938.0, "length": 586, "protein_name": "Kelch-like protein 7", "gene_name": "Klhl7", "organism": "Mouse", "refseq_name": "kelch-like protein 7 isoform 1", "refseq_ac": "NP_080724", "gene_names_uniprotkb": "Klhl7", "gene_names_refseq": "2700038B03Rik; D5Ertd363e; Klhl7; SBBI26", "protein_names_uniprotkb": "Kelch-like protein 7", "protein_names_refseq": "BTB/POZ domain containing protein; kelch-like protein 7 isoform 1; kelch-like protein 7", "tax_id": 10090, "disease": "cold-induced sweating syndrome 3 (Disease Ontology:DOID:0080331); retinitis pigmentosa 42 (Disease Ontology:DOID:0110386)", "pathway": " (mmu:52323)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZP4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BUL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JT5-1", "uniprot_id": "KRCC1_MOUSE", "mass": 30718.0, "length": 256, "protein_name": "Lysine-rich coiled-coil protein 1", "gene_name": "Krcc1", "organism": "Mouse", "refseq_name": "lysine-rich coiled-coil protein 1", "refseq_ac": "NP_663543", "gene_names_uniprotkb": "Krcc1", "gene_names_refseq": "Krcc1", "protein_names_uniprotkb": "Lysine-rich coiled-coil protein 1", "protein_names_refseq": "lysine-rich coiled-coil protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:57896)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Regulates CHEK1-mediated cell cycle checkpoint. Facilitates efficient recombination and homologous recombination repair. Required for proper S-phase progression and mitotic entry., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99JT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61955-1", "uniprot_id": "KLK8_MOUSE", "mass": 28524.0, "length": 260, "protein_name": "Kallikrein-8", "gene_name": "Klk8", "organism": "Mouse", "refseq_name": "kallikrein-8 preproprotein", "refseq_ac": "NP_001311327", "gene_names_uniprotkb": "Klk8; Nrpn; Prss19", "gene_names_refseq": "BSP1; Klk8; NP; Nrpn; Prss19", "protein_names_uniprotkb": "Kallikrein-8; 3.4.21.118; NP; Neuropsin; Serine protease 19; mK8", "protein_names_refseq": "Brain Serine protease 1; kallikrein-8 preproprotein; kallikrein-8; protease, serine, 19 (neuropsin)", "tax_id": 10090, "disease": "", "pathway": " (mmu:259277); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "10196465;10421059;10762375;10773678;11273653;11274744;11549709;11880192;12354676;12944500;14616360;16308352;16537644;17182622;17629414;17761692;21750661;33341972;33754057;37076499;7623137;8602273;8864305;9374276;9556608;9620300;9749739;9933620", "class_list": "", "function": "A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic knockdown of Klk8 has sex-specific multi-targeted therapeutic effects on Alzheimer's pathology in mice., [RefSeq, PubMed]; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]., [RefSeq]; Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K5D7", "ec_number_list": "3.4.21.118", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0097180 serine protease inhibitor complex", "go_biological_process": "GO:0006508 proteolysis;GO:0007613 memory;GO:0050808 synapse organization;GO:0048812 neuron projection morphogenesis;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q61955-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P9L6-1", "uniprot_id": "KIF15_MOUSE", "mass": 160120.0, "length": 1387, "protein_name": "Kinesin-like protein KIF15", "gene_name": "Kif15", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF15", "refseq_ac": "NP_034750", "gene_names_uniprotkb": "Kif15; Klp2; Knsl7", "gene_names_refseq": "3110023M17Rik; 3930402I10Rik; D330038N01; HKLP2; Kif15; Knsl7; b2b1117.1Clo; b2b1117.1aClo", "protein_names_uniprotkb": "Kinesin-like protein KIF15; Kinesin-like protein 2; Kinesin-like protein 7", "protein_names_refseq": "N-10 kinesin; kinesin 15; kinesin-like 7; kinesin-like protein 2; kinesin-like protein 7; kinesin-like protein KIF15", "tax_id": 10090, "disease": "", "pathway": " (mmu:209737); (R-MMU-2132295); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "14618103;21750661;25428506;28528544;30084848;31219806;31599954;34428180;35835966;36934586;37256467;37828378;39627609;9275178", "class_list": "", "function": "Deficiency of Kif15 gene inhibits tumor growth due to host CD8[+]T lymphocytes increase., [RefSeq, PubMed]; Kif15 deficiency contributes to depression-like behavior in mice., [RefSeq, PubMed]; Kif15 opposes the capacity of other motors to generate independent microtubule movements within key regions of developing neurons., [RefSeq, PubMed]; Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis. Publication Status: Online-Only, [RefSeq, PubMed]; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35065;Q70MX5", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement;GO:0051299 centrosome separation;GO:0000278 mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6P9L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02956-1", "uniprot_id": "KPCZ_MOUSE", "mass": 67682.0, "length": 592, "protein_name": "Protein kinase C zeta type", "gene_name": "Prkcz", "organism": "Mouse", "refseq_name": "protein kinase C zeta type isoform a", "refseq_ac": "NP_032886", "gene_names_uniprotkb": "Prkcz; Pkcz", "gene_names_refseq": "Pkcz; Prkcz; aPKCzeta; nPKC-zeta; zetaPKC", "protein_names_uniprotkb": "Protein kinase C zeta type; 2.7.11.13; nPKC-zeta", "protein_names_refseq": "atypical protein kinase C; protein kinase C zeta subspecies; protein kinase C zeta type isoform a; protein kinase C zeta type", "tax_id": 10090, "disease": "carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18762); (R-MMU-2173791); (R-MMU-5218921); (R-MMU-5668599); (R-MMU-9634635)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10934474;12932816;1487145;15987782;16792529;17313651;19887597;21131967;21183079;21750661;22333836;23283171;27187150;29249667;34428180", "class_list": "", "function": "Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Involved in late synaptic long term potentiation phase in CA1 hippocampal cells and long term memory maintenance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AD76;Q3UHM5;Q7TST7", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;3.6.5.2;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.7.11.30;2.3.1.48;4.1.1.32;2.7.1.91;2.7.11.38;3.6.1.-;3.6.-.-;2.3.2.26;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;5.2.1.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0098978 glutamatergic synapse;GO:0035748 myelin sheath abaxonal region;GO:0045179 apical cortex;GO:0005634 nucleus", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1905609 positive regulation of smooth muscle cell-matrix adhesion;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q02956-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922S8-1", "uniprot_id": "KIF2C_MOUSE", "mass": 81085.0, "length": 721, "protein_name": "Kinesin-like protein KIF2C", "gene_name": "Kif2c", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF2C isoform 1", "refseq_ac": "NP_608301", "gene_names_uniprotkb": "Kif2c", "gene_names_refseq": "4930402F02Rik; ESTM5; Kif2c; Knsl6; MCAK", "protein_names_uniprotkb": "Kinesin-like protein KIF2C; MCAK; Mitotic centromere-associated kinesin", "protein_names_refseq": "kinesin-like 6; kinesin-like protein KIF2C isoform 1; kinesin-like protein KIF2C; mitotic centromere-associated kinesin", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:73804); (R-MMU-141430); (R-MMU-141444); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-6811434); (R-MMU-68877); (R-MMU-9648025); (R-MMU-983189)", "pathway_count": 11, "publication_count": 13, "publication_id_list": "14980225;16741559;19283064;20406800;21750661;22872234;30084848;31219806;34203471;34428180;35138249;37431690;39627609", "class_list": "", "function": "Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice., [RefSeq, PubMed]; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:14980225). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (By similarity)., [UniProtKB, UniProtKB, PubMed]; KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization. Publication Status: Online-Only, [RefSeq, PubMed]; MCAK appears to possess a unique distribution and function in oocyte maturation., [RefSeq, PubMed]; Possible functions of MCAK at the inner centromere domain and at the perikinetochoric ring during both meiotic divisions., [RefSeq, PubMed]; Shugoshin 2 is necessary for the loading of MCAK at the inner centromere, but is dispensable for the loading of the outer kinetochore proteins BubR1 and CENP-E., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AE71", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0051010 microtubule plus-end binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q922S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80X45-1", "uniprot_id": "KISHB_MOUSE", "mass": 8308.0, "length": 74, "protein_name": "Protein kish-B", "gene_name": "Tmem167b", "organism": "Mouse", "refseq_name": "protein kish-B precursor", "refseq_ac": "NP_080474", "gene_names_uniprotkb": "Tmem167b", "gene_names_refseq": "2010200O16Rik; Tmem167b", "protein_names_uniprotkb": "Protein kish-B; Transmembrane protein 167B", "protein_names_refseq": "protein kish-B precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:67495)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Involved in the early part of the secretory pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U299;Q8BL15;Q9D863", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0045054 constitutive secretory pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80X45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UN02-1", "uniprot_id": "LCLT1_MOUSE", "mass": 44400.0, "length": 376, "protein_name": "Lysocardiolipin acyltransferase 1", "gene_name": "Lclat1", "organism": "Mouse", "refseq_name": "lysocardiolipin acyltransferase 1", "refseq_ac": "NP_001074540", "gene_names_uniprotkb": "Lclat1; Agpat8; Alcat1; Gm91; Lycat", "gene_names_refseq": "1-AGPAT 8; Agpat8; Alcat1; Gm91; Lclat1; Lycat", "protein_names_uniprotkb": "Lysocardiolipin acyltransferase 1; 1-AGP acyltransferase 8; 1-AGPAT 8; 1-acylglycerol-3-phosphate O-acyltransferase 8; 2.3.1.-; 2.3.1.51; Acyl-CoA:lysocardiolipin acyltransferase 1", "protein_names_refseq": "1-AGP acyltransferase 8; 1-acylglycerol-3-phosphate O-acyltransferase 8; acyl-CoA:lysocardiolipin acyltransferase 1; lysocardiolipin acyltransferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:225010); (R-MMU-1482798); (R-MMU-1483166)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15152008;16620771;17675553;19372376;20668164;21750661;30838774;35772643;36336228", "class_list": "", "function": "ALCAT1 expression is upregulated by MPTP and by alpha-synucleinopathy, a key hallmark of Parkinson's disease (PD), whereas ALCAT1 deficiency prevented alpha-synuclein oligomerization and S-129 phosphorylation, implicating a key role of ALCAT1 in the etiology of mouse models of PD., [RefSeq, PubMed]; Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (PubMed:15152008). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (PubMed:15152008). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Possesses lysophosphatidylinositol acyltransferase (LPIAT) activity (PubMed:20668164). Possesses lysophosphatidylglycerol acyltransferase (LPGAT) activity (By similarity). Required for establishment of the hematopoietic and endothelial lineages (PubMed:17675553)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Identification and characterization of a gene that encodes an acyl-CoA:lysocardiolipin acyltransferase 1, [RefSeq, PubMed]; Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~40%., [RefSeq, PubMed]; Irisin and ALCAT1 mediated aerobic exercise-alleviated oxidative stress and apoptosis in skeletal muscle of mice with myocardial infarction., [RefSeq, PubMed]; Mouse Lycat plays an important role in the early specification of hematopoietic and endothelial cells., [RefSeq, PubMed]; Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.51;2.3.1.15;2.3.1.23;2.3.1.67;2.3.1.25;2.3.1.-;2.3.1.121;2.3.1.n6;2.3.1.n7;3.1.1.4;3.1.1.3;2.3.1.22;2.3.1.62", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0035965 cardiolipin acyl-chain remodeling;GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0036149 phosphatidylinositol acyl-chain remodeling;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UN02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXT6-1", "uniprot_id": "KDM8_MOUSE", "mass": 47145.0, "length": 414, "protein_name": "Bifunctional peptidase and arginyl-hydroxylase JMJD5", "gene_name": "Kdm8", "organism": "Mouse", "refseq_name": "bifunctional peptidase and arginyl-hydroxylase JMJD5", "refseq_ac": "NP_084118", "gene_names_uniprotkb": "Kdm8; Jmjd5", "gene_names_refseq": "3110005O21Rik; Jmjd5; Kdm8", "protein_names_uniprotkb": "Bifunctional peptidase and arginyl-hydroxylase JMJD5; 1.14.11.73; 3.4.-.-; JmjC domain-containing protein 5; Jumonji C domain-containing protein 5; L-arginine (3R)-hydroxylase KDM8; Lysine-specific demethylase 8", "protein_names_refseq": "L-arginine (3R)-hydroxylase KDM8; arginyl C3-hydroxylase KDM8; bifunctional peptidase and arginyl-hydroxylase JMJD5; jmjC domain-containing protein 5; jumonji C domain-containing protein 5; jumonji domain containing 5; jumonji domain-containing protein 5; lysine-specific demethylase 8", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:77035); (R-MMU-9629569)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;22241836;22402282;30500822;34428180", "class_list": "", "function": "Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage. Additionally, acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established. Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation. Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition. Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation. Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (By similarity). Regulates the circadian gene expression in the liver (PubMed:30500822). Represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a catalytically-independent manner (By similarity). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822)., [UniProtKB, UniProtKB, PubMed]; Collectively, these data indicate that JMJD5 is essential during embryonal development and a repressor of p53 expression. The latter suggests that JMJD5 has oncogenic activity and accordingly JMJD5 is upregulated in leukemias and breast cancer. Erratum:[Biochem Biophys Res Commun. 2015 Sep 11;465(1):166], [RefSeq, PubMed]; Results suggest that Jmjd5 physiologically moderates embryonic cell proliferation through the epigenetic control of Cdkn1a expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.-.-;1.14.11.73", "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0003682 chromatin binding;GO:0004175 endopeptidase activity;GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0000086 G2/M transition of mitotic cell cycle;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CXT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6Q783-1", "uniprot_id": "KMT5C_MOUSE", "mass": 53159.0, "length": 468, "protein_name": "Histone-lysine N-methyltransferase KMT5C", "gene_name": "Kmt5c", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase KMT5C isoform 1", "refseq_ac": "NP_001108490", "gene_names_uniprotkb": "Kmt5c; Suv420h2", "gene_names_refseq": "Kmt5c; Suv4-20h2; Suv420h2", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase KMT5C; 2.1.1.361; 2.1.1.362; Lysine-specific methyltransferase 5C; Su(var)4-20 homolog 2; Suppressor of variegation 4-20 homolog 2; Suv4-20h2; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B", "protein_names_refseq": "[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase KMT5C isoform 1; histone-lysine N-methyltransferase KMT5C; histone-lysine N-methyltransferase SUV420H2; lysine-specific methyltransferase 5C; su(var)4-20 homolog 2; suppressor of variegation 4-20 homolog 2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); liver benign neoplasm (Disease Ontology:DOID:916)", "pathway": " (mmu:232811); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15145825;15750587;16612004;17846168;21750661;24049080;25428506;28114273;33144397;38713533", "class_list": "", "function": "H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:15145825, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (PubMed:15145825). Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions (PubMed:15145825). KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (PubMed:15750587, PubMed:16612004). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The histone methyltransferase SUV420H2 regulates brown and beige adipocyte thermogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; There is a novel role for histone lysine methylation in controlling telomere recombination., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5RKP6;Q8R1C5", "ec_number_list": "2.1.1.-;2.1.1.364;2.1.1.361;2.1.1.362;2.1.1.359;2.1.1.355;2.1.1.354", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0042393 histone binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0042799 histone H4K20 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000792 heterochromatin;GO:0000779 condensed chromosome, centromeric region;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0032259 methylation;GO:0045830 positive regulation of isotype switching", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6Q783-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGA5-1", "uniprot_id": "KRR1_MOUSE", "mass": 43538.0, "length": 380, "protein_name": "KRR1 small subunit processome component homolog", "gene_name": "Krr1", "organism": "Mouse", "refseq_name": "KRR1 small subunit processome component homolog", "refseq_ac": "NP_848725", "gene_names_uniprotkb": "Krr1; Hrb2", "gene_names_refseq": "2610511F02Rik; D10Ertd773e; Hrb2; Krr1", "protein_names_uniprotkb": "KRR1 small subunit processome component homolog; HIV-1 Rev-binding protein 2 homolog; KRR-R motif-containing protein 1", "protein_names_refseq": "HIV-1 Rev binding protein 2; HIV-1 Rev-binding protein 2 homolog; KRR-R motif-containing protein 1; KRR1 small subunit processome component homolog; KRR1, small subunit processome component", "tax_id": 10090, "disease": "", "pathway": " (mmu:52705); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIG9;Q52KQ6;Q5EBJ5;Q8C029", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0045171 intercellular bridge;GO:0005694 chromosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSM7-1", "uniprot_id": "LAT3_MOUSE", "mass": 62644.0, "length": 564, "protein_name": "Large neutral amino acids transporter small subunit 3", "gene_name": "Slc43a1", "organism": "Mouse", "refseq_name": "large neutral amino acids transporter small subunit 3 isoform 3", "refseq_ac": "NP_001077278", "gene_names_uniprotkb": "Slc43a1; Lat3", "gene_names_refseq": "2610016F07Rik; Lat3; PB39; Pov1; R00504; Slc43a1", "protein_names_uniprotkb": "Large neutral amino acids transporter small subunit 3; L-type amino acid transporter 3; Solute carrier family 43 member 1", "protein_names_refseq": "L-type amino acid transporter 3; large neutral amino acids transporter small subunit 3 isoform 3; large neutral amino acids transporter small subunit 3; prostate cancer overexpressed gene 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72401); (R-MMU-352230)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17242355;17322374;19349973;19443642;21183079;21750661;31219806;34428180", "class_list": "", "function": "Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine (PubMed:17322374). The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion (PubMed:17322374). Mediates the efflux of 3,3'-diiodo-L-thyronine (3,3'-T2) and 3-iodo-L-tyrosine (MIT) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2ATS3;Q9D0H7", "ec_number_list": "", "go_molecular_function": "GO:0015188 L-isoleucine transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015190 L-leucine transmembrane transporter activity;GO:0005304 L-valine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane;GO:0098846 podocyte foot", "go_biological_process": "GO:0015820 L-leucine transport;GO:0015804 neutral amino acid transport;GO:0015807 L-amino acid transport;GO:0051956 negative regulation of amino acid transport;GO:0015818 isoleucine transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BSM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCD7-1", "uniprot_id": "KDM4C_MOUSE", "mass": 119966.0, "length": 1054, "protein_name": "Lysine-specific demethylase 4C", "gene_name": "Kdm4c", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 4C isoform 2", "refseq_ac": "NP_001165566", "gene_names_uniprotkb": "Kdm4c; Jhdm3c; Jmjd2c; Kiaa0780", "gene_names_refseq": "2410141F18Rik; Gasc1; Jmjd2c; Kdm4c", "protein_names_uniprotkb": "Lysine-specific demethylase 4C; 1.14.11.66; JmjC domain-containing histone demethylation protein 3C; Jumonji domain-containing protein 2C; [histone H3]-trimethyl-L-lysine(9) demethylase 4C", "protein_names_refseq": "[histone H3]-trimethyl-L-lysine(9) demethylase 4C; gene amplified in squamous cell carcinoma 1; jmjC domain-containing histone demethylation protein 3C; jumonji domain containing 2C; jumonji domain-containing protein 2C; lysine-specific demethylase 4C isoform 2; lysine-specific demethylase 4C", "tax_id": 10090, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); withdrawal disorder (Disease Ontology:DOID:0060001); prostate cancer (Disease Ontology:DOID:10283); head and neck cancer (Disease Ontology:DOID:11934); autistic disorder (Disease Ontology:DOID:12849); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); stomach carcinoma (Disease Ontology:DOID:5517); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:76804); (R-MMU-3214842)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "17938240;21750661;25428506;28457889;30084848;31599954;34428180;36012577;36210013;36709354;38421303;38975736", "class_list": "", "function": "Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate., [UniProtKB, UniProtKB]; Jmjd2c acts as a positive regulator for Nanog, which encodes for a key transcription factor for self-renewal in ES cells., [RefSeq, PubMed]; Jmjd2c maintains the ALDH[bri+] cancer stemness with transcription factor SOX2 in lung squamous cell carcinoma., [RefSeq, PubMed]; KDM4C promotes mouse hippocampal neural stem cell proliferation through modulating ApoE expression., [RefSeq, PubMed]; The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2[V617F] mutated cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNP7;Q69ZZ5;Q8BUY6;Q8BWA1", "ec_number_list": "1.14.11.66;1.14.11.69;1.14.11.-;1.14.11.79", "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VCD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70188-1", "uniprot_id": "KIFA3_MOUSE", "mass": 91291.0, "length": 793, "protein_name": "Kinesin-associated protein 3", "gene_name": "Kifap3", "organism": "Mouse", "refseq_name": "kinesin-associated protein 3 isoform KAP3A", "refseq_ac": "NP_001292572", "gene_names_uniprotkb": "Kifap3", "gene_names_refseq": "KAP-3; KAP3; Kifap3; SMAP", "protein_names_uniprotkb": "Kinesin-associated protein 3; KAP-3; KAP3", "protein_names_refseq": "kinesin-associated protein 3 isoform KAP3A", "tax_id": 10090, "disease": "", "pathway": " (mmu:16579); (R-MMU-2132295); (R-MMU-5620924); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16298999;21183079;25428506;30084848;31219806;34428180;8710890", "class_list": "", "function": "Interaction of KIF3A/3B with KAP3 may be important for the proper progression of mitosis., [RefSeq, PubMed]; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex., [UniProtKB]; The protein encoded by this gene is the non-motor subunit of kinesin-2 complex, and forms a heterotrimer with two members of the kinesin superfamily of proteins that together form a microtubule plus-end directed translocator that plays an important role in intracellular transport, mitosis, and cell-cell adhesion. This protein contains multiple armadillo repeats involved in protein binding, and may serve as an adaptor to regulate binding of cargo with the motor proteins. Conditional disruption of this gene in mouse neural precursor cells caused a tumor-like phenotype and defective organization of the neuroepithelium thought to be the result of altered N-cadherin subcellular localization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70189;Q6GTS3", "ec_number_list": "", "go_molecular_function": "GO:0019894 kinesin binding;GO:0019903 protein phosphatase binding;GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000794 condensed nuclear chromosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0046587 positive regulation of calcium-dependent cell-cell adhesion;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0007018 microtubule-based movement;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70188-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97329-1", "uniprot_id": "KI20A_MOUSE", "mass": 99876.0, "length": 887, "protein_name": "Kinesin-like protein KIF20A", "gene_name": "Kif20a", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF20A", "refseq_ac": "NP_001159878", "gene_names_uniprotkb": "Kif20a; Rab6kifl", "gene_names_refseq": "Kif20a; Rab6kifl", "protein_names_uniprotkb": "Kinesin-like protein KIF20A; Kinesin-like protein 174; Rab6-interacting kinesin-like protein; Rabkinesin-6", "protein_names_refseq": "Rabkinesin-6; kinesin-like protein 174; kinesin-like protein KIF20A; rab6-interacting kinesin-like protein", "tax_id": 10090, "disease": "familial restrictive cardiomyopathy 6 (Disease Ontology:DOID:0061025)", "pathway": " (mmu:19348); (R-MMU-2132295); (R-MMU-6811434); (R-MMU-68884); (R-MMU-983189)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "21750661;25428506;30779550;31219806;33976373;35820727;9438855", "class_list": "", "function": "Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth. Publication Status: Online-Only, [RefSeq, PubMed]; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle (By similarity). Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542M4", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005819 spindle", "go_biological_process": "GO:0015031 protein transport;GO:0000281 mitotic cytokinesis;GO:0007018 microtubule-based movement;GO:0032465 regulation of cytokinesis;GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97329-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97861-1", "uniprot_id": "KRT86_MOUSE", "mass": 53251.0, "length": 486, "protein_name": "Keratin, type II cuticular Hb6", "gene_name": "Krt86", "organism": "Mouse", "refseq_name": "keratin, type II cuticular Hb6", "refseq_ac": "NP_034797", "gene_names_uniprotkb": "Krt86; Krt2-10; Krthb6", "gene_names_refseq": "5430421N21Rik; K86; Khb4; Krt2-10; Krt2-11; Krt86; MHb4", "protein_names_uniprotkb": "Keratin, type II cuticular Hb6; K86; Keratin-86; Type II hair keratin Hb6; Type-II keratin Kb26", "protein_names_refseq": "keratin complex 2, basic, gene 10; keratin, type II cuticular Hb6; type II hair keratin Hb6; type-II keratin Kb26", "tax_id": 10090, "disease": "monilethrix 1 (Disease Ontology:DOID:0061145); hair disease (Disease Ontology:DOID:421)", "pathway": " (mmu:16679); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9084137", "class_list": "", "function": "Structural component of intermediate filaments in the hair shaft. Forms obligate heterodimers with type I hair keratins, which assemble into keratin intermediate filaments that contribute to the structural integrity and mechanical strength of the hair shaft., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTV9", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97861-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05CL8-1", "uniprot_id": "LARP7_MOUSE", "mass": 64802.0, "length": 570, "protein_name": "La-related protein 7", "gene_name": "Larp7", "organism": "Mouse", "refseq_name": "la-related protein 7", "refseq_ac": "NP_613059", "gene_names_uniprotkb": "Larp7; D3Wsu161e", "gene_names_refseq": "C330027G06Rik; D3Wsu161e; Larp7", "protein_names_uniprotkb": "La-related protein 7; La ribonucleoprotein domain family member 7", "protein_names_refseq": "La ribonucleoprotein domain family, member 7; la-related protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:28036)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "17242355;17525332;21183079;21750661;22645316;22865833;23154982;25153642;25605945;28135057;28528544;32017896;34428180;38818612", "class_list": "", "function": "LARP7 overexpression alleviates aortic senescence and atherosclerosis., [RefSeq, PubMed]; RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:32017896). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (By similarity). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (By similarity). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (By similarity). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017896). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017896). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017896). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (By similarity). U6 snRNA processing is required for spermatogenesis (PubMed:32017896)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSC2;Q8K2Y6;Q8VDW3;Q9CSI2;Q9CSI9;Q9CUQ5", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0097322 7SK snRNA binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex;GO:0120259 7SK snRNP", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:1904871 positive regulation of protein localization to Cajal body;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q05CL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U2K5-1", "uniprot_id": "KDM4D_MOUSE", "mass": 57212.0, "length": 510, "protein_name": "Lysine-specific demethylase 4D", "gene_name": "Kdm4d", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 4D", "refseq_ac": "NP_775609", "gene_names_uniprotkb": "Kdm4d; Jhdm3d; Jmjd2d", "gene_names_refseq": "4932416A15; Jmjd2d; Kdm4d", "protein_names_uniprotkb": "Lysine-specific demethylase 4D; 1.14.11.66; JmjC domain-containing histone demethylation protein 3D; Jumonji domain-containing protein 2D; [histone H3]-trimethyl-L-lysine(9) demethylase 4D", "protein_names_refseq": "[histone H3]-trimethyl-L-lysine(9) demethylase 4D; jmjC domain-containing histone demethylation protein 3D; jumonji domain containing 2D; jumonji domain-containing protein 2D; lysine-specific demethylase 4D", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); nephroblastoma (Disease Ontology:DOID:2154)", "pathway": " (mmu:244694); (R-MMU-3214842)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21293030;21750661;30059200;35145029;38905308;39034148", "class_list": "", "function": "Histone demethylase JMJD2D protects against enteric bacterial infection via up-regulating colonic IL-17F to induce beta-defensin expression. Publication Status: Online-Only, [RefSeq, PubMed]; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate., [UniProtKB, UniProtKB]; Kdm4d mutant mice show impaired sperm motility and subfertility., [RefSeq, PubMed]; TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation., [RefSeq, PubMed]; These results suggest that demethylation of H3K9 in round spermatids is dispensable for spermatogenesis but that possible defects in Kdm4d-null elongating spermatids could be rescued by functional redundancy of the KDM4B demethylase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2CGB5;B8JK34;Q2M1G7;Q8BI19", "ec_number_list": "1.14.11.66;1.14.11.69;1.14.11.-;1.14.11.79", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003684 damaged DNA binding;GO:0031490 chromatin DNA binding;GO:0032452 histone demethylase activity;GO:0032454 histone H3K9 demethylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0035861 site of double-strand break;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3U2K5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHG7-1", "uniprot_id": "DEN11_MOUSE", "mass": 51428.0, "length": 455, "protein_name": "DENN domain-containing protein 11", "gene_name": "Dennd11", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 11", "refseq_ac": "NP_001343304", "gene_names_uniprotkb": "Dennd11; E330009J07Rik; Kiaa1147; Lchn", "gene_names_refseq": "Dennd11; E330009J07Rik; Lchn; mKIAA1147", "protein_names_uniprotkb": "DENN domain-containing protein 11; DENND11; Protein LCHN", "protein_names_refseq": "DENN domain-containing protein 11; protein LCHN", "tax_id": 10090, "disease": "", "pathway": " (mmu:243780)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;32848054;35820727", "class_list": "", "function": "Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT59;Q80TI8;Q8C6M2", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UHG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UWM4-1", "uniprot_id": "KDM7A_MOUSE", "mass": 106075.0, "length": 940, "protein_name": "Lysine-specific demethylase 7A", "gene_name": "Kdm7a", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 7A", "refseq_ac": "NP_001028602", "gene_names_uniprotkb": "Kdm7a; Jhdm1d; Kdm7; Kiaa1718", "gene_names_refseq": "A630082K20Rik; Jhdm1d; Kdm7a; mKIAA1718", "protein_names_uniprotkb": "Lysine-specific demethylase 7A; 1.14.11.65; JmjC domain-containing histone demethylation protein 1D; Lysine-specific demethylase 7; [histone H3]-dimethyl-L-lysine9 demethylase 7A", "protein_names_refseq": "[histone H3]-dimethyl-L-lysine9 demethylase 7A; jmjC domain-containing histone demethylation protein 1D; jumonji C domain-containing histone demethylase 1 homolog D; lysine-specific demethylase 7A; lysine-specific demethylase 7", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); melanoma (Disease Ontology:DOID:1909)", "pathway": " (mmu:338523); (R-MMU-3214842)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "18299400;19224205;20173027;20194436;20484733;20629981;21952136;22872234;25428506;27802388;30084848;30779550;31219806;34203471;34428180;34681759;35820727;35984892;36210013;37565374;38346941", "class_list": "", "function": "A JmjC domain-containing protein that catalyzes demethylation of both mono- or dimethylated H3K9 and H3K27 [KDM7], [RefSeq, PubMed]; Histone Demethylase KDM7A Contributes to the Development of Hepatic Steatosis by Targeting Diacylglycerol Acyltransferase 2. Publication Status: Online-Only, [RefSeq, PubMed]; Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate., [UniProtKB, UniProtKB, PubMed]; The KIAA1718, a PHF2/PHF8 subfamily member, possesses histone demethylase activity specific for H3K9 and H3K27, transcriptionally repressive histone marks., [RefSeq, PubMed]; The Lysine Demethylase KDM7A Regulates Immediate Early Genes in Neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6E5;Q3UWN8;Q6ZPJ5;Q8C969;Q8C9E0;Q91VX8", "ec_number_list": "1.14.11.68;1.14.11.-;1.14.11.65;1.14.99.66", "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0051864 histone H3K36 demethylase activity;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0030901 midbrain development", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q3UWM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UXL4-1", "uniprot_id": "KIZ_MOUSE", "mass": 76542.0, "length": 695, "protein_name": "Centrosomal protein kizuna", "gene_name": "Kiz", "organism": "Mouse", "refseq_name": "centrosomal protein kizuna", "refseq_ac": "NP_001028470", "gene_names_uniprotkb": "Kiz; Gm114; Plk1s1", "gene_names_refseq": "Gm114; Kiz; Ncrna00153; Plk1s1", "protein_names_uniprotkb": "Centrosomal protein kizuna; Polo-like kinase 1 substrate 1", "protein_names_refseq": "centrosomal protein kizuna; polo-like kinase 1 substrate 1", "tax_id": 10090, "disease": "retinitis pigmentosa 69 (Disease Ontology:DOID:0110410)", "pathway": " (mmu:228730)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18423593;21183079;21750661;34428180", "class_list": "", "function": "Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results describe the expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUS7;B2RX19", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0007051 spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UXL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497I4-1", "uniprot_id": "KRT35_MOUSE", "mass": 50530.0, "length": 455, "protein_name": "Keratin, type I cuticular Ha5", "gene_name": "Krt35", "organism": "Mouse", "refseq_name": "keratin, type I cuticular Ha5", "refseq_ac": "NP_058576", "gene_names_uniprotkb": "Krt35; Krt1-24", "gene_names_refseq": "Ha5; Krt1-24; Krt35; Krtha5", "protein_names_uniprotkb": "Keratin, type I cuticular Ha5; Hair keratin, type I Ha5; K35; Keratin-35", "protein_names_refseq": "K35; hair keratin acidic 5; hair keratin, type I Ha5; keratin complex 1, acidic, gene 24; keratin complex 1, gene 24; keratin, hair, acidic, 5; keratin, type I cuticular Ha5", "tax_id": 10090, "disease": "", "pathway": " (mmu:53617); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "18021261;34428180", "class_list": "", "function": "Transfected human p65 induces transcriptional activation of mouse Ha5., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RU48;Q9Z2T8", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q497I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4G5Y1-1", "uniprot_id": "KLDC2_MOUSE", "mass": 45909.0, "length": 406, "protein_name": "Kelch domain-containing protein 2", "gene_name": "Klhdc2", "organism": "Mouse", "refseq_name": "kelch domain-containing protein 2", "refseq_ac": "NP_081393", "gene_names_uniprotkb": "Klhdc2", "gene_names_refseq": "2310022K15Rik; D12Ertd522e; HCLP-1; Klhdc2; LCP", "protein_names_uniprotkb": "Kelch domain-containing protein 2; Endothelial differentiation inhibitory protein TNG", "protein_names_refseq": "endothelial differentiation inhibitory protein TNG; kelch domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69554)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16008511;16860314;25428506", "class_list": "", "function": "A conserved but uncharacterized gene encoding Klhdc2, which was down-regulated during endothelial differentiation, was identified., [RefSeq, PubMed]; Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine (By similarity). The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation (By similarity). May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding (By similarity)., [UniProtKB, UniProtKB]; These results suggest that a tightly controlled expression of mKlhdc2 is essential for a faithful execution of the myogenic differentiation and migration program., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKN6;Q99JY2;Q9D784", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0016604 nuclear body;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4G5Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DT36-1", "uniprot_id": "KLRI2_MOUSE", "mass": 28848.0, "length": 248, "protein_name": "Killer cell lectin-like receptor subfamily I member 2", "gene_name": "Klri2", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor subfamily I member 2", "refseq_ac": "NP_796129", "gene_names_uniprotkb": "Klri2", "gene_names_refseq": "A530090P03Rik; Klri2", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily I member 2", "protein_names_refseq": "killer cell lectin-like receptor subfamily I member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:320407)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15650876", "class_list": "glycogene", "function": "Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates NK cell cytolytic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 53, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BS07", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0002228 natural killer cell mediated immunity;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0002223 stimulatory C-type lectin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5DT36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60654-1", "uniprot_id": "KLRA7_MOUSE", "mass": 32522.0, "length": 280, "protein_name": "Killer cell lectin-like receptor 7", "gene_name": "Klra7", "organism": "Mouse", "refseq_name": "killer cell lectin-like receptor 7 isoform 1", "refseq_ac": "NP_001103793", "gene_names_uniprotkb": "Klra7; Ly-49g; Ly49-g; Ly49g4; Ly49g", "gene_names_refseq": "Klra7; LGL-1; Ly-49G.1; Ly-49G.2; Ly-49G.3; Ly49G.4; Ly49g1; Ly49g2; Ly49g", "protein_names_uniprotkb": "Killer cell lectin-like receptor 7; Ly-49g; Lymphocyte antigen 49g; T-cell surface glycoprotein Ly-49G", "protein_names_refseq": "T-cell surface glycoprotein Ly-49G; killer cell lectin-like receptor 7 isoform 1; killer cell lectin-like receptor 7; ly-49g; lymphocyte antigen 49g", "tax_id": 10090, "disease": "", "pathway": " (mmu:16638)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18426793;21750661;24797174;34428180;7964501;8027540", "class_list": "", "function": "Receptor on natural killer (NK) cells for class I MHC., [UniProtKB]; The ectodomain of inhibitory Ly49G of the BALB/c mouse strain is highly similar to the Ly49W activating receptor in the nonobese diabetic (NOD) mouse., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q60655;Q60656;Q60683", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q60654-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60961-1", "uniprot_id": "LAP4A_MOUSE", "mass": 26858.0, "length": 233, "protein_name": "Lysosomal-associated transmembrane protein 4A", "gene_name": "Laptm4a", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Laptm4a; Mtrp", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysosomal-associated transmembrane protein 4A; Golgi 4-transmembrane-spanning transporter; MTP; Mouse transporter protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "22872234;25428506;30084848;31219806;34428180;36210013;8621662", "class_list": "", "function": "May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0097213 regulation of lysosomal membrane permeability", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q60961-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61790-1", "uniprot_id": "LAG3_MOUSE", "mass": 56978.0, "length": 521, "protein_name": "Lymphocyte activation gene 3 protein", "gene_name": "Lag3", "organism": "Mouse", "refseq_name": "lymphocyte activation gene 3 protein precursor", "refseq_ac": "NP_032505", "gene_names_uniprotkb": "Lag3", "gene_names_refseq": "CD223; LAG-3; Lag3; Ly66", "protein_names_uniprotkb": "Lymphocyte activation gene 3 protein; Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; LAG-3", "protein_names_refseq": "activation-induced cytidine deaminase-linked autoimmunity protein; aida; lymphocyte activation gene 3 protein precursor; lymphocyte activation gene 3 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:16768); (R-MMU-2132295)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "11937541;12209638;12421911;12672063;15100286;15485628;15557174;15634887;17245433;19201841;21300912;21873518;26740625;30349037;30580966;35413245;35761082;38483996;39209860;40101708;40592325;8602528;8921170", "class_list": "", "function": "Inhibitory receptor on antigen activated T-cells (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887, PubMed:30580966, PubMed:35413245, PubMed:35761082, PubMed:38483996, PubMed:39209860). Delivers inhibitory signals upon binding to ligands, such as MHC class II, its main ligand present at the surface of antigen-presenting cells (APCs), and FGL1, which is secreted by hepatocytes and certain types of tumor cells (PubMed:12209638, PubMed:12421911, PubMed:30349037, PubMed:30580966, PubMed:35413245, PubMed:35761082, PubMed:39209860). Ligand-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell activation (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887). Mechanistically, ligand-binding promotes (1) ubiquitination of the KIEELE motif, unleashing the RRFSALE motif from the membrane and (2) leading to the formation of condensates with the TCR component CD3E, thereby disrupting the association between CD3E and LCK and preventing TCR activation (PubMed:40101708, PubMed:40592325). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1 (PubMed:21300912). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (PubMed:15485628). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (PubMed:19201841)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response., [UniProtKB, PubMed]; The LAG3-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBL2", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042289 MHC class II protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002270 plasmacytoid dendritic cell activation;GO:0032703 negative regulation of interleukin-2 production;GO:0007166 cell surface receptor signaling pathway;GO:0050776 regulation of immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q61790-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64520-1", "uniprot_id": "KGUA_MOUSE", "mass": 21918.0, "length": 198, "protein_name": "Guanylate kinase", "gene_name": "Guk1", "organism": "Mouse", "refseq_name": "guanylate kinase isoform 1", "refseq_ac": "NP_032219", "gene_names_uniprotkb": "Guk1; Gmk", "gene_names_refseq": "Gmk; Guk-1; Guk1", "protein_names_uniprotkb": "Guanylate kinase; 2.7.4.8; GMP kinase; Guanylate kinase 1", "protein_names_refseq": "GMP kinase; guanylate kinase isoform 1", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome-21 (Disease Ontology:DOID:0051029); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:14923); (R-MMU-499943); (R-MMU-9748787)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12036965;21750661;29515371;31219806;34428180;8663313", "class_list": "", "function": "Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:8663313). Involved in the cGMP metabolism in photoreceptors (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q564F2;Q564G0", "ec_number_list": "2.7.4.8", "go_molecular_function": "GO:0004385 GMP kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0019673 GDP-mannose metabolic process;GO:0006185 dGDP biosynthetic process;GO:0046054 dGMP metabolic process;GO:0046060 dATP metabolic process;GO:0046711 GDP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64520-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IMF0-1", "uniprot_id": "KRT87_MOUSE", "mass": 54629.0, "length": 495, "protein_name": "Keratin, type II cuticular 87", "gene_name": "Krt87", "organism": "Mouse", "refseq_name": "keratin, type II cuticular 87", "refseq_ac": "NP_001003668", "gene_names_uniprotkb": "Krt87; Kb25; Krt2-25; Krt83", "gene_names_refseq": "K83; K87; Krt2-25; Krt83; Krt87", "protein_names_uniprotkb": "Keratin, type II cuticular 87; K87; Keratin-87", "protein_names_refseq": "keratin complex 2, basic, gene 25; keratin, type II cuticular 87; keratin, type II cuticular Hb3; keratin-83; type II hair keratin Hb3; type-II keratin Kb23; type-II keratin Kb25", "tax_id": 10090, "disease": "monilethrix 1 (Disease Ontology:DOID:0061145); monilethrix 2 (Disease Ontology:DOID:0061152); monilethrix 3 (Disease Ontology:DOID:0061153); erythrokeratodermia variabilis et progressiva 5 (Disease Ontology:DOID:0080251); breast cancer (Disease Ontology:DOID:1612); hair disease (Disease Ontology:DOID:421)", "pathway": " (mmu:406219); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15085952", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTF5", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IMF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P9P6-1", "uniprot_id": "KIF11_MOUSE", "mass": 118027.0, "length": 1052, "protein_name": "Kinesin-like protein KIF11", "gene_name": "Kif11", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF11", "refseq_ac": "NP_034745", "gene_names_uniprotkb": "Kif11", "gene_names_refseq": "Eg5; Kif11; Kif8; Kifl1; Knsl1", "protein_names_uniprotkb": "Kinesin-like protein KIF11; Kinesin-related motor protein Eg5", "protein_names_refseq": "kinesin-like 1; kinesin-like protein KIF11; kinesin-related motor protein Eg5", "tax_id": 10090, "disease": "microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (Disease Ontology:DOID:0060349)", "pathway": " (mmu:16551); (R-MMU-2132295); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10659681;21952136;22872234;26495903;34428180;34887587;37752791;37757917;39627609", "class_list": "", "function": "Inhibition of KIF11 ameliorates osteoclastogenesis via regulating mTORC1-mediated NF-kappaB signaling., [RefSeq, PubMed]; LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A., [RefSeq, PubMed]; Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1J0", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0046602 regulation of mitotic centrosome separation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement;GO:0007051 spindle organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6P9P6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6V595-1", "uniprot_id": "KLHL6_MOUSE", "mass": 70191.0, "length": 619, "protein_name": "Kelch-like protein 6", "gene_name": "Klhl6", "organism": "Mouse", "refseq_name": "kelch-like protein 6 isoform 1", "refseq_ac": "NP_899246", "gene_names_uniprotkb": "Klhl6", "gene_names_refseq": "Klhl6", "protein_names_uniprotkb": "Kelch-like protein 6", "protein_names_refseq": "kelch-like protein 6 isoform 1; kelch-like protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:239743)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12617994;16166635;26018251;26495903;28807996;30084848;30779550;32152506;34428180", "class_list": "", "function": "Related to islet dysfunction during the development of type 2 diabetes, [RefSeq, PubMed]; Report that KLHL6, which is recurrently mutated in B cell lymphomas, is an off-target of the normal somatic hypermutation process taking place in germinal center (GC) B cells leaving open whether, despite the lack of impact of Klhl6 deficiency on GC B cell expansion, mutants could contribute to the oncogenic process, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a multifunctional regulator of B-cell receptor (BCR) signaling, germinal center formation, and T-cell function (PubMed:16166635). Functions by mediating polyubiquitination of target proteins, leading to their proteasomal degradation. In B-cells, plays an essential role in BCR signaling and germinal center B-cell maturation. Targets the BCR signaling subunits CD79A and CD79B for ubiquitin-mediated degradation, thereby controlling surface BCR homeostasis. Mediates polyubiquitination and degradation of the mRNA decay factor roquin-2/RC3H2, which in turn allows accumulation of TNFAIP3, a negative regulator of NF-kappa-B signaling, thereby providing feedback inhibition of BCR-induced NF-kappa-B activation. In T-cells, acts as a dual negative regulator of T-cell exhaustion and mitochondrial dysfunction. Promotes 'Lys-48'-linked polyubiquitination and proteasomal degradation of the transcription factor TOX, thereby attenuating the transition of progenitor exhausted T-cells towards terminal exhaustion. Also targets the mitochondrial phosphatase PGAM5 for degradation, thereby preventing excessive PGAM5-mediated dephosphorylation and activation of DRP1, which would otherwise drive pathological mitochondrial fission. Through these mechanisms, maintains mitochondrial fitness in T-cells during chronic antigen stimulation., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497G3", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0009617 response to bacterium;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050853 B cell receptor signaling pathway;GO:0002467 germinal center formation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6V595-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPT1-1", "uniprot_id": "KLHL9_MOUSE", "mass": 69400.0, "length": 617, "protein_name": "Kelch-like protein 9", "gene_name": "Klhl9", "organism": "Mouse", "refseq_name": "kelch-like protein 9", "refseq_ac": "NP_766459", "gene_names_uniprotkb": "Klhl9; Kiaa1354", "gene_names_refseq": "8030469P05; C530050O22Rik; Klhl9; mKIAA1354", "protein_names_uniprotkb": "Kelch-like protein 9", "protein_names_refseq": "kelch-like protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:242521); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "25428507;25605945;30084848;31219806;34428180", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505G5", "ec_number_list": "", "go_molecular_function": "GO:0097602 cullin family protein binding;GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030496 midbody;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6ZPT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG84-1", "uniprot_id": "LAIR1_MOUSE", "mass": 29793.0, "length": 263, "protein_name": "Leukocyte-associated immunoglobulin-like receptor 1", "gene_name": "Lair1", "organism": "Mouse", "refseq_name": "leukocyte-associated immunoglobulin-like receptor 1 isoform a precursor", "refseq_ac": "NP_001106945", "gene_names_uniprotkb": "Lair1", "gene_names_refseq": "5133400O11Rik; D7Bwg0421e; Lair-1; Lair1", "protein_names_uniprotkb": "Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; mLAIR1", "protein_names_refseq": "leukocyte-associated immunoglobulin-like receptor 1 isoform a precursor; leukocyte-associated immunoglobulin-like receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:52855); (R-MMU-198933); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15100296;16380958;26495903;30084848;34948139;38448779;38696927", "class_list": "", "function": "1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity)., [UniProtKB, PubMed]; Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis., [RefSeq, PubMed]; Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression., [RefSeq, PubMed]; Mouse Lair-1 cytoplasmic tail can become phosphorylated, thereby recruiting SH2-containing tyrosine phosphatase-2 (SHP-2). Unlike human LAIR-1, SHP-1 is not recruited to the mouse Lair-1 cytoplasmic tail., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80UN5;Q8BHB6;Q8BRR6;Q8C6N8;Q8CEP5", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0140375 immune receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BG84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BW72-1", "uniprot_id": "KDM4A_MOUSE", "mass": 120334.0, "length": 1064, "protein_name": "Lysine-specific demethylase 4A", "gene_name": "Kdm4a", "organism": "Mouse", "refseq_name": "lysine-specific demethylase 4A isoform 1", "refseq_ac": "NP_001155295", "gene_names_uniprotkb": "Kdm4a; Jhdm3a; Jmjd2a; Jmjd2; Kiaa0677", "gene_names_refseq": "D4Ertd222e; JHDM3A; Jmjd2a; Jmjd2; Kdm4a; mKIAA0677", "protein_names_uniprotkb": "Lysine-specific demethylase 4A; 1.14.11.66; 1.14.11.69; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A; [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A", "protein_names_refseq": "[histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; jmjC domain-containing histone demethylation protein 3A; jumonji domain containing 2A; jumonji domain-containing protein 2A; lysine-specific demethylase 4A isoform 1; lysine-specific demethylase 4A", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); stomach carcinoma (Disease Ontology:DOID:5517); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:230674); (R-MMU-3214842); (R-MMU-5693565)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16024779;21750661;24953653;25428506;31599954;34428180;34678516;38008899;38411359", "class_list": "", "function": "Astrocyte KDM4A mediates chemokines and drives neutrophil infiltration to aggravate cerebral ischemia and reperfusion injury., [RefSeq, PubMed]; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:24953653). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20' (By similarity). Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues (By similarity). Demethylation of Lys residue generates formaldehyde and succinate. Also able to demethylate histone H1-4 methylated at 'Lys-26' (H1.4K26me1, H1.4K26me2 and H1.4K26me3) (By similarity). Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (By similarity)., [UniProtKB, UniProtKB, PubMed]; JMJD2A mediates transcriptional activation of SFRP4 and regulates oxidative stress and mitochondrial dysfunction in heart failure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A8L8;Q3UKM5;Q3UM81;Q3UWV2;Q6ZQ72;Q8K137", "ec_number_list": "1.14.11.27;2.3.2.23;2.3.2.-;3.6.-.-;1.14.11.66;2.3.2.26;3.1.-.-;2.7.11.1;2.3.2.27;2.1.1.357;1.14.11.69;1.14.11.-;1.14.11.79;2.3.1.48;2.3.1.-", "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0032452 histone demethylase activity;GO:0032454 histone H3K9 demethylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BW72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0N1-1", "uniprot_id": "KIF2B_MOUSE", "mass": 75469.0, "length": 668, "protein_name": "Kinesin-like protein KIF2B", "gene_name": "Kif2b", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF2B", "refseq_ac": "NP_082823", "gene_names_uniprotkb": "Kif2b", "gene_names_refseq": "1700063D03Rik; Kif2b", "protein_names_uniprotkb": "Kinesin-like protein KIF2B", "protein_names_refseq": "kinesin-like protein KIF2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:73470); (R-MMU-141430); (R-MMU-141444); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-6811434); (R-MMU-68877); (R-MMU-9648025); (R-MMU-983189)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "25428506;30059200", "class_list": "", "function": "Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement during mitosis. Has microtubule depolymerization activity. Plays a role in chromosome congression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007019 microtubule depolymerization;GO:0051983 regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C0N1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGR5-1", "uniprot_id": "KLK14_MOUSE", "mass": 27016.0, "length": 250, "protein_name": "Kallikrein-14", "gene_name": "Klk14", "organism": "Mouse", "refseq_name": "kallikrein-14 preproprotein", "refseq_ac": "NP_777355", "gene_names_uniprotkb": "Klk14; Gk14", "gene_names_refseq": "GK14; Klk14", "protein_names_uniprotkb": "Kallikrein-14; 3.4.21.-; Glandular kallikrein KLK14; Kallikrein related-peptidase 14; mGK14", "protein_names_refseq": "glandular kallikrein KLK14; kallikrein-14 preproprotein; kallikrein-14", "tax_id": 10090, "disease": "", "pathway": " (mmu:317653); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12437987", "class_list": "", "function": "Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis (By similarity)., [UniProtKB, UniProtKB]; This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The encoded protein is a precursor that undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. The encoded enzyme was found to activate the complement pathway by cleavage of C3 to release C3a anaphylotoxin. This gene is one of the several glandular kallikrein genes located in a cluster on chromosome 7. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.-", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0006508 proteolysis;GO:0009566 fertilization;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CGR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIG3-1", "uniprot_id": "KDM1B_MOUSE", "mass": 92633.0, "length": 826, "protein_name": "Lysine-specific histone demethylase 1B", "gene_name": "Kdm1b", "organism": "Mouse", "refseq_name": "lysine-specific histone demethylase 1B isoform 1", "refseq_ac": "NP_758466", "gene_names_uniprotkb": "Kdm1b; Aof1; Lsd2", "gene_names_refseq": "4632428N09Rik; Aof1; Kdm1b", "protein_names_uniprotkb": "Lysine-specific histone demethylase 1B; 1.14.99.66; Flavin-containing amine oxidase domain-containing protein 1; Lysine-specific histone demethylase 2", "protein_names_refseq": "amine oxidase, flavin containing 1; flavin-containing amine oxidase domain-containing protein 1; lysine-specific histone demethylase 1B isoform 1; lysine-specific histone demethylase 1B; lysine-specific histone demethylase 2", "tax_id": 10090, "disease": "retinoblastoma (Disease Ontology:DOID:768)", "pathway": " (mmu:218214); (R-MMU-3214842); (R-MMU-5689603)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "19407342;19727073;20101264;21183079;21750661;22951486;35820727;36542318;36976514", "class_list": "", "function": "AOF1 is the second histone demethylase in the family of flavin-dependent amine oxidases and reveals a demethylase-independent repression function. Erratum:[Cell Res. 2010 Jul;20(7):858. Stewart, David M [corrected to Stewart, M David]], [RefSeq, PubMed]; Data indicate that Myst4, Jmjd2b, Aof1 genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia., [RefSeq, PubMed]; Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (PubMed:19407342, PubMed:19727073). Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B., [RefSeq, PubMed]; Lysine Demethylase 1B Promotes Tear Secretion Disorder in Sjogren's Syndrome by Regulating the PAX6/CLU Axis., [RefSeq, PubMed]; Oocytes from KDM1B-deficient females showed a substantial increase in H3K4 methylation and failed to set up the DNA methylation marks at four out of seven imprinted genes examined, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5C4;Q8CEC1", "ec_number_list": "1.14.11.-;1.14.11.65;1.14.99.66;3.4.19.12", "go_molecular_function": "GO:0032453 histone H3K4 demethylase activity;GO:0008270 zinc ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0071514 genomic imprinting;GO:0044726 epigenetic programing of female pronucleus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CIG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0Y2-1", "uniprot_id": "KT33A_MOUSE", "mass": 46137.0, "length": 404, "protein_name": "Keratin, type I cuticular Ha3-I", "gene_name": "Krt33a", "organism": "Mouse", "refseq_name": "keratin, type I cuticular Ha3-I", "refseq_ac": "NP_082259", "gene_names_uniprotkb": "Krt33a", "gene_names_refseq": "2310015J09Rik; Krt33a", "protein_names_uniprotkb": "Keratin, type I cuticular Ha3-I; Hair keratin, type I Ha3-I; K33A; Keratin-33A", "protein_names_refseq": "K33A; hair keratin, type I Ha3-I; keratin, type I cuticular Ha3-I; ortholog of keratin, hair, acidic, 3A KRTHA3A", "tax_id": 10090, "disease": "", "pathway": " (mmu:71888); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7C4", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K0Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R124-1", "uniprot_id": "KLH36_MOUSE", "mass": 69950.0, "length": 613, "protein_name": "Kelch-like protein 36", "gene_name": "Klhl36", "organism": "Mouse", "refseq_name": "kelch-like protein 36", "refseq_ac": "NP_666331", "gene_names_uniprotkb": "Klhl36", "gene_names_refseq": "Klhl36", "protein_names_uniprotkb": "Kelch-like protein 36", "protein_names_refseq": "kelch-like protein 36", "tax_id": 10090, "disease": "", "pathway": " (mmu:234796)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31219806;34428180;35820727", "class_list": "", "function": "Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0B9;Q6KAS2", "ec_number_list": "", "go_molecular_function": "GO:0097602 cullin family protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R124-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VE3-1", "uniprot_id": "KLK7_MOUSE", "mass": 27257.0, "length": 249, "protein_name": "Kallikrein-7", "gene_name": "Klk7", "organism": "Mouse", "refseq_name": "kallikrein-7 preproprotein", "refseq_ac": "NP_036002", "gene_names_uniprotkb": "Klk7; Prss6; Scce", "gene_names_refseq": "Klk7; Prss6; SCCE", "protein_names_uniprotkb": "Kallikrein-7; 3.4.21.117; Serine protease 6; Stratum corneum chymotryptic enzyme; Thymopsin", "protein_names_refseq": "kallikrein 7 (chymotryptic, stratum corneum); kallikrein-7 preproprotein; kallikrein-7; kallikrein-related peptidase 7; serine protease 6; stratum corneum chymotryptic enzyme; thymopsin", "tax_id": 10090, "disease": "", "pathway": " (mmu:23993); (R-MMU-1474228)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10469296;28095415;28932870;29311134;31883963", "class_list": "", "function": "A previously unrecognized role of KLK7 in adipose tissue with effects on whole body energy expenditure and insulin sensitivity., [RefSeq, PubMed]; Ablation of KLK7 is not sufficient to rescue the lethal effect of LEKTI-deficiency. Double deficiency of both KLK7 and KLK5 completely rescues Netherton Syndrome-like phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; KLK7 is an important enzyme in the degradation and clearance of deposited Amyloid beta species by astrocytes involved in the pathogenesis of Alzheimer's disease., [RefSeq, PubMed]; Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation., [RefSeq, PubMed]; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines., [UniProtKB]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R048", "ec_number_list": "3.4.24.35;3.4.21.117", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0097209 epidermal lamellar body;GO:0001533 cornified envelope", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation;GO:0002803 positive regulation of antibacterial peptide production;GO:0002780 antibacterial peptide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91VE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWU5-1", "uniprot_id": "KHDC3_MOUSE", "mass": 47995.0, "length": 440, "protein_name": "KH domain-containing protein 3", "gene_name": "Khdc3", "organism": "Mouse", "refseq_name": "KH domain-containing protein 3 isoform 2", "refseq_ac": "NP_001298035", "gene_names_uniprotkb": "Khdc3; 2410004A20Rik", "gene_names_refseq": "2410004A20Rik; FILIA; Khdc3; OEEP48", "protein_names_uniprotkb": "KH domain-containing protein 3; Protein Filia", "protein_names_refseq": "KH domain-containing protein 3 isoform 2; KH domain-containing protein 3; protein Filia", "tax_id": 10090, "disease": "gestational trophoblastic neoplasm (Disease Ontology:DOID:3590)", "pathway": " (mmu:66991)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "17913455;18057100;18804437;19376971;20823540;21750661;22276159;25208553;25936915;28992324;29125140;31575650;33115731;36266342;37922900;38177687", "class_list": "", "function": "Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (PubMed:18804437, PubMed:19376971, PubMed:25208553, PubMed:28992324, PubMed:29125140, PubMed:31575650, PubMed:37922900). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:31575650, PubMed:37922900). They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (PubMed:37922900). KHDC3 ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (PubMed:19376971). Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (PubMed:19376971). As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (PubMed:29125140, PubMed:33115731). Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation (PubMed:25936915, PubMed:33115731). Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific (PubMed:25936915, PubMed:33115731). Its role in DNA double-strand break repair is independent of its role in restarting stalled replication forks (PubMed:29125140). Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus (PubMed:33115731). May regulate normal development of learning, memory and anxiety (PubMed:33115731). Capable of binding RNA (PubMed:22276159)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Filia is central to integrating the spatiotemporal localization of regulators that helps ensure euploidy and high-quality cell cycle progression in preimplantation mouse development., [RefSeq, PubMed]; Results describe a subcortical maternal complex, containing Mater, Floped, TLE6, and Filia, that is essential for preimplantation mouse embryogenesis., [RefSeq, PubMed]; The plasticity of the FILIA-MATER complex localization may reflect the regulative nature of preimplantation mouse development., [RefSeq, PubMed]; This paper states that the ECAT1 gene is absent in rodents., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7YIL2;Q9CRD6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0140094 structural constituent of cytoplasmic lattice", "go_cellular_component": "GO:0045179 apical cortex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007015 actin filament organization;GO:0043066 negative regulation of apoptotic process;GO:0090307 mitotic spindle assembly;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9CWU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D638-1", "uniprot_id": "KRA32_MOUSE", "mass": 10574.0, "length": 99, "protein_name": "Keratin-associated protein 3-2", "gene_name": "Krtap3-2", "organism": "Mouse", "refseq_name": "keratin-associated protein 3-3", "refseq_ac": "NP_079800", "gene_names_uniprotkb": "Krtap3-2; Krtap3-3", "gene_names_refseq": "2310020D06Rik; KAP3.3; KRTAP3.3; Krtap3-3", "protein_names_uniprotkb": "Keratin-associated protein 3-2; Keratin-associated protein 3-3", "protein_names_refseq": "keratin-associated protein 3-2; keratin-associated protein 3-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66380); (mmu:66708); (R-MMU-6805567)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CPW1", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D638-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D646-1", "uniprot_id": "KRT34_MOUSE", "mass": 44560.0, "length": 392, "protein_name": "Keratin, type I cuticular Ha4", "gene_name": "Krt34", "organism": "Mouse", "refseq_name": "keratin, type I cuticular Ha4", "refseq_ac": "NP_081839", "gene_names_uniprotkb": "Krt34; Ha4; Krt1-4", "gene_names_refseq": "4733401E01Rik; Ha2; K34; Krt1-4; Krt34", "protein_names_uniprotkb": "Keratin, type I cuticular Ha4; Hair keratin, type I Ha4; K34; Keratin-34", "protein_names_refseq": "hair keratin, type I Ha4; keratin complex 1, acidic, gene 4; keratin, type I cuticular Ha4", "tax_id": 10090, "disease": "", "pathway": " (mmu:16672); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "1689759", "class_list": "", "function": "The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D646-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9P8-1", "uniprot_id": "LCFC1_MOUSE", "mass": 12138.0, "length": 108, "protein_name": "Sperm-egg fusion protein LLCFC1", "gene_name": "Llcfc1", "organism": "Mouse", "refseq_name": "sperm-egg fusion protein LLCFC1 isoform 1 precursor", "refseq_ac": "NP_083947", "gene_names_uniprotkb": "Llcfc1; Sof1", "gene_names_refseq": "1700034O15Rik; Llcfc1; Sofu1", "protein_names_uniprotkb": "Sperm-egg fusion protein LLCFC1; LLLL and CFNLAS motif-containing protein 1; MSSP-binding protein CTM-1; Sperm-oocyte fusion required protein 1", "protein_names_refseq": "LLLL and CFNLAS motif containing 1; LLLL and CFNLAS motif-containing protein 1; MSSP-binding protein CTM-1; sperm-egg fusion protein LLCFC1 isoform 1 precursor; sperm-egg fusion protein LLCFC1; sperm-oocyte fusion required protein 1; uncharacterized protein C7orf34 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76606)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32393636", "class_list": "", "function": "Sperm protein required for fusion of sperm with the egg membrane during fertilization., [UniProtKB, PubMed]; Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D9P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAE3-1", "uniprot_id": "LELP1_MOUSE", "mass": 12755.0, "length": 120, "protein_name": "Late cornified envelope-like proline-rich protein 1", "gene_name": "Lelp1", "organism": "Mouse", "refseq_name": "late cornified envelope-like proline-rich protein 1", "refseq_ac": "NP_081318", "gene_names_uniprotkb": "Lelp1", "gene_names_refseq": "1700012F11Rik; Lelp1", "protein_names_uniprotkb": "Late cornified envelope-like proline-rich protein 1", "protein_names_refseq": "ate cornified envelope-like proline-rich 1; late cornified envelope-like proline-rich protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69332)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNZ8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DAE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI74-1", "uniprot_id": "KLHL1_MOUSE", "mass": 82892.0, "length": 751, "protein_name": "Kelch-like protein 1", "gene_name": "Klhl1", "organism": "Mouse", "refseq_name": "kelch-like protein 1", "refseq_ac": "NP_444335", "gene_names_uniprotkb": "Klhl1", "gene_names_refseq": "Klhl1; mKIAA1490", "protein_names_uniprotkb": "Kelch-like protein 1", "protein_names_refseq": "kelch-l like; kelch-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:93688)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10888605;20147652;25428506", "class_list": "", "function": "KLHL1 interacts with Cav3.2 and modulates T-type calcium currents by increasing current deactivation kinetics and current density and calcium influx., [RefSeq, PubMed]; May play a role in organizing the actin cytoskeleton of the brain cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q505E9", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0007626 locomotory behavior;GO:0016358 dendrite development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0007628 adult walking behavior;GO:0021680 cerebellar Purkinje cell layer development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JI74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYN3-1", "uniprot_id": "KLK11_MOUSE", "mass": 30754.0, "length": 276, "protein_name": "Kallikrein-11", "gene_name": "Klk11", "organism": "Mouse", "refseq_name": "kallikrein-11 isoform 1 preproprotein", "refseq_ac": "NP_001170844", "gene_names_uniprotkb": "Klk11; Prss20", "gene_names_refseq": "2310015I08Rik; Klk11; Prss20; TLSP", "protein_names_uniprotkb": "Kallikrein-11; 3.4.21.-; Hippostasin; Serine protease 20", "protein_names_refseq": "hippostasin; kallikrein-11 isoform 1 preproprotein; kallikrein-11; serine protease 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:56538)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11072088;28867182;34059001;36689511", "class_list": "", "function": "KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy. Publication Status: Online-Only, [RefSeq, PubMed]; Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin (By similarity)., [UniProtKB]; This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]., [RefSeq]; Together, our results suggest that KLF4 regulates asthma development in a TSLP- and fibrocyte-dependent manner., [RefSeq, PubMed]; Variants in KLK11, affecting signal peptide cleavage of kallikrein-related peptidase 11, cause an autosomal-dominant cornification disorder., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYN4", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QYN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R088-1", "uniprot_id": "KITM_MOUSE", "mass": 31209.0, "length": 270, "protein_name": "Thymidine kinase 2, mitochondrial", "gene_name": "Tk2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tk2", "gene_names_refseq": "", "protein_names_uniprotkb": "Thymidine kinase 2, mitochondrial; 2'-deoxyuridine kinase TK2; 2.7.1.-; 2.7.1.21; 2.7.1.74; Deoxycytidine kinase TK2; Mt-TK", "protein_names_refseq": "", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 2 (Disease Ontology:DOID:0080120); autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3 (Disease Ontology:DOID:0111523)", "pathway": " (R-MMU-73614)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10571069;11023833;21750661", "class_list": "", "function": "Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix (PubMed:11023833). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.21;2.7.1.74;2.7.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0004137 deoxycytidine kinase activity;GO:0004797 thymidine kinase activity;GO:0019136 deoxynucleoside kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0046092 deoxycytidine metabolic process;GO:0046104 thymidine metabolic process;GO:0006264 mitochondrial DNA replication;GO:0032042 mitochondrial DNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R088-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WV04-1", "uniprot_id": "KIF9_MOUSE", "mass": 89898.0, "length": 790, "protein_name": "Kinesin-like protein KIF9", "gene_name": "Kif9", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF9 isoform 2", "refseq_ac": "NP_034758", "gene_names_uniprotkb": "Kif9", "gene_names_refseq": "Kif9", "protein_names_uniprotkb": "Kinesin-like protein KIF9", "protein_names_refseq": "kinesin 9; kinesin-like protein KIF9 isoform 2; kinesin-like protein KIF9", "tax_id": 10090, "disease": "", "pathway": " (mmu:16578); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;32072696;34428180;34526446;35820727;39158699;9275178", "class_list": "", "function": "Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility., [RefSeq, PubMed]; Essential for normal male fertility and for progressive motility of spermatozoa., [UniProtKB, PubMed]; The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMT7;O35070", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0002102 podosome", "go_biological_process": "GO:0071801 regulation of podosome assembly;GO:1903008 organelle disassembly;GO:0022617 extracellular matrix disassembly;GO:0007018 microtubule-based movement;GO:1901317 regulation of flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WV04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVB6-1", "uniprot_id": "LENEP_MOUSE", "mass": 6923.0, "length": 61, "protein_name": "Lens epithelial cell protein LEP503", "gene_name": "Lenep", "organism": "Mouse", "refseq_name": "lens epithelial cell protein LEP503", "refseq_ac": "NP_065263", "gene_names_uniprotkb": "Lenep; Lep503", "gene_names_refseq": "Lenep; Lep503", "protein_names_uniprotkb": "Lens epithelial cell protein LEP503", "protein_names_refseq": "lens epithelial cell protein LEP503; lens epithelial protein 503", "tax_id": 10090, "disease": "", "pathway": " (mmu:57275)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10655141;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WVB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D226-1", "uniprot_id": "KRA53_MOUSE", "mass": 17777.0, "length": 196, "protein_name": "Keratin-associated protein 5-3", "gene_name": "Krtap5-3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Krtap5-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin-associated protein 5-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:77215)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D226-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61087-1", "uniprot_id": "LAMB3_MOUSE", "mass": 128900.0, "length": 1168, "protein_name": "Laminin subunit beta-3", "gene_name": "Lamb3", "organism": "Mouse", "refseq_name": "laminin subunit beta-3 precursor", "refseq_ac": "NP_001264857", "gene_names_uniprotkb": "Lamb3", "gene_names_refseq": "Lamb3", "protein_names_uniprotkb": "Laminin subunit beta-3; Epiligrin subunit beta; Kalinin B1 chain; Kalinin subunit beta; Laminin-5 subunit beta; Nicein subunit beta", "protein_names_refseq": "epiligrin subunit bata; epiligrin subunit beta; kalinin B1 chain; kalinin subunit beta; laminin subunit beta-3 precursor; laminin subunit beta-3; laminin-5 subunit beta; nicein subunit beta; nicein, 125kDa", "tax_id": 10090, "disease": "junctional epidermolysis bullosa Herlitz type (Disease Ontology:DOID:0060737); junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); amelogenesis imperfecta type 1A (Disease Ontology:DOID:0110054); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (mmu:16780)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;38102338;7898049", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB]; SOX10 deficiency-mediated LAMB3 upregulation determines the invasiveness of MAPKi-resistant melanoma., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91V90", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0043256 laminin complex;GO:0005610 laminin-5 complex", "go_biological_process": "GO:0016477 cell migration;GO:0050873 brown fat cell differentiation;GO:0009887 animal organ morphogenesis;GO:0034446 substrate adhesion-dependent cell spreading;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61087-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61292-1", "uniprot_id": "LAMB2_MOUSE", "mass": 196579.0, "length": 1799, "protein_name": "Laminin subunit beta-2", "gene_name": "Lamb2", "organism": "Mouse", "refseq_name": "laminin subunit beta-2 precursor", "refseq_ac": "NP_032509", "gene_names_uniprotkb": "Lamb2; Lams", "gene_names_refseq": "Lamb-2; Lamb2; Lams; npht", "protein_names_uniprotkb": "Laminin subunit beta-2; Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-LAM beta; S-laminin subunit beta", "protein_names_refseq": "Laminin S; S-LAM beta; S-laminin subunit beta; laminin subunit beta-2 precursor; laminin subunit beta-2; laminin-11 subunit beta; laminin-14 subunit beta; laminin-15 subunit beta; laminin-3 subunit beta; laminin-4 subunit beta; laminin-7 subunit beta; laminin-9 subunit beta", "tax_id": 10090, "disease": "Pierson syndrome (Disease Ontology:DOID:0060852); nephrotic syndrome type 5 (Disease Ontology:DOID:0080380); primary open angle glaucoma (Disease Ontology:DOID:1070); nephrosis (Disease Ontology:DOID:2527); proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:16779)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30084848;30899004;33300544;34428180;36288343;39927985;7885444;8043959;8662701", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB, PubMed]; Laminin-3 (S-laminin) regulates the formation of motor nerve terminals., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 5, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q62182;Q8R0Y0", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0150043 structural constituent of synapse-associated extracellular matrix", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction;GO:0045202 synapse;GO:0043083 synaptic cleft", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0016477 cell migration;GO:0031175 neuron projection development;GO:0045785 positive regulation of cell adhesion;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q61292-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R008-1", "uniprot_id": "KIME_MOUSE", "mass": 41877.0, "length": 395, "protein_name": "Mevalonate kinase", "gene_name": "Mvk", "organism": "Mouse", "refseq_name": "mevalonate kinase isoform 2", "refseq_ac": "NP_076045", "gene_names_uniprotkb": "Mvk", "gene_names_refseq": "2310010A05Rik; MK; Mvk", "protein_names_uniprotkb": "Mevalonate kinase; 2.7.1.36; MK", "protein_names_refseq": "mevalonate kinase isoform 2", "tax_id": 10090, "disease": "mevalonic aciduria (Disease Ontology:DOID:0050452); hyperimmunoglobulinemia D periodic fever syndrome (Disease Ontology:DOID:0081450); cancer (Disease Ontology:DOID:162); lipid metabolism disorder (Disease Ontology:DOID:3146); porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (mmu:17855); (R-MMU-9969896)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10401001;21750661;25605945", "class_list": "", "function": "Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis., [UniProtKB, UniProtKB]; This gene encodes mevalonate kinase, a key enzyme involved in the biosynthesis of cholesterol and non-sterol isoprenes. The complete lack of encoded protein is lethal to mouse embryos. Mice lacking one allele of this gene exhibit increased levels of mevalonate in spleen, heart and kidney, as well as increased levels of serum immunoglobulins A and D. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.36", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0000287 magnesium ion binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0006695 cholesterol biosynthetic process;GO:0017148 negative regulation of translation;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0033386 geranylgeranyl diphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R008-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48999-1", "uniprot_id": "LOX5_MOUSE", "mass": 77967.0, "length": 674, "protein_name": "Polyunsaturated fatty acid 5-lipoxygenase", "gene_name": "Alox5", "organism": "Mouse", "refseq_name": "polyunsaturated fatty acid 5-lipoxygenase", "refseq_ac": "NP_033792", "gene_names_uniprotkb": "Alox5", "gene_names_refseq": "5-LOX; 5-LO; 5LO; 5LX; Alox5; F730011J02", "protein_names_uniprotkb": "Polyunsaturated fatty acid 5-lipoxygenase; 1.13.11.-; 1.13.11.34; 5-LO; 5-lipoxygenase; Arachidonate 5-lipoxygenase", "protein_names_refseq": "5-lipoxygenase; polyunsaturated fatty acid 5-lipoxygenase", "tax_id": 10090, "disease": "exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); pleurisy (Disease Ontology:DOID:10247); common cold (Disease Ontology:DOID:10459); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); pulmonary edema (Disease Ontology:DOID:11396); nephrotic syndrome (Disease Ontology:DOID:1184); pancreatic cancer (Disease Ontology:DOID:1793); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); pulmonary fibrosis (Disease Ontology:DOID:3770); cholangiocarcinoma (Disease Ontology:DOID:4947); pulmonary hypertension (Disease Ontology:DOID:6432); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (mmu:11689); (R-MMU-2142688); (R-MMU-2142691); (R-MMU-2142700); (R-MMU-6798695); (R-MMU-9018676); (R-MMU-9018682); (R-MMU-9018896); (R-MMU-9020265); (R-MMU-9023661); (R-MMU-9026286); (R-MMU-9026290); (R-MMU-9026403); (R-MMU-9027604)", "pathway_count": 14, "publication_count": 17, "publication_id_list": "17392829;18421434;21224059;21307302;21750661;23246375;23720274;24226420;24906289;28694473;28965882;31642348;34428180;39082787;7629107;7809134;7969451", "class_list": "", "function": "Catalyzes the oxygenation of arachidonate to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:23246375, PubMed:31642348, PubMed:7629107, PubMed:7809134, PubMed:7969451). Also catalyzes the oxygenation of arachidonic acid into 8-hydroperoxyicosatetraenoic acid (8-HPETE) and 12-hydroperoxyicosatetraenoic acid (12-HPETE) (PubMed:23246375). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (By similarity). Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:31642348). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (PubMed:21307302). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31642348). In addition to inflammatory processes, participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (PubMed:17392829, PubMed:23720274, PubMed:24226420, PubMed:28965882). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21224059). May also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (PubMed:18421434, PubMed:28694473). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (PubMed:24906289)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Inhibition of host 5-lipoxygenase reduces overexuberant inflammatory responses and mortality associated with Cryptococcus meningoencephalitis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB75", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;1.13.11.-;1.13.11.58;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;2.7.10.2;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;1.13.11.31;1.13.11.33;1.13.11.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.34;2.7.11.1;1.11.1.7;3.1.6.12;2.7.1.40;3.5.4.5;3.4.25.1;2.7.11.39;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;4.4.1.20;2.5.1.-;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;2.7.1.35;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016787 hydrolase activity;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0036403 arachidonate 8(S)-lipoxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005641 nuclear envelope lumen;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0034440 lipid oxidation;GO:0061044 negative regulation of vascular wound healing;GO:2001301 lipoxin biosynthetic process;GO:0006954 inflammatory response;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P48999-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16125-1", "uniprot_id": "LDHB_MOUSE", "mass": 36572.0, "length": 334, "protein_name": "L-lactate dehydrogenase B chain", "gene_name": "Ldhb", "organism": "Mouse", "refseq_name": "L-lactate dehydrogenase B chain isoform 2", "refseq_ac": "NP_001289694", "gene_names_uniprotkb": "Ldhb; Ldh-2; Ldh2", "gene_names_refseq": "H-Ldh; LDH-B; LDH-H; Ldh-2; Ldh2; Ldhb", "protein_names_uniprotkb": "L-lactate dehydrogenase B chain; 1.1.1.27; LDH heart subunit; LDH-B; LDH-H", "protein_names_refseq": "L-lactate dehydrogenase B chain isoform 2; L-lactate dehydrogenase B chain; LDH heart subunit; lactate dehydrogenase 2, B chain", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667)", "pathway": " (mmu:16832); (R-MMU-70268)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "18034455;21183079;21750661;2338075;25605945;32152506;33300544;34428180;35820727;36288343;37507081;37828378;39927985", "class_list": "", "function": "Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes 1 and 19. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545Y4", "ec_number_list": "1.1.1.27", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0019900 kinase binding;GO:0004459 L-lactate dehydrogenase (NAD+) activity;GO:0004457 lactate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0043209 myelin sheath;GO:0045121 membrane raft", "go_biological_process": "GO:0019674 NAD+ metabolic process;GO:0019244 lactate biosynthetic process from pyruvate;GO:0006089 lactate metabolic process;GO:0042867 pyruvate catabolic process;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P16125-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88609-1", "uniprot_id": "LMX1B_MOUSE", "mass": 44102.0, "length": 395, "protein_name": "LIM homeobox transcription factor 1-beta", "gene_name": "Lmx1b", "organism": "Mouse", "refseq_name": "LIM homeobox transcription factor 1-beta", "refseq_ac": "NP_034855", "gene_names_uniprotkb": "Lmx1b", "gene_names_refseq": "Icst; LMX1.1; LMX1.2; Lmx1b", "protein_names_uniprotkb": "LIM homeobox transcription factor 1-beta; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B; LMX-1.2", "protein_names_refseq": "GENA 191; LIM homeo box transcription factor 1B; LIM homeobox transcription factor 1-beta; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B; LMX-1.2", "tax_id": 10090, "disease": "nail-patella syndrome (Disease Ontology:DOID:9467)", "pathway": " (mmu:16917)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;9590288", "class_list": "", "function": "Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VEN6", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0002930 trabecular meshwork development;GO:0042048 olfactory behavior;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88609-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNU7-1", "uniprot_id": "LETM2_MOUSE", "mass": 54458.0, "length": 480, "protein_name": "LETM1 domain-containing protein LETM2, mitochondrial", "gene_name": "Letm2", "organism": "Mouse", "refseq_name": "LETM1 domain-containing protein LETM2, mitochondrial isoform 1 precursor", "refseq_ac": "NP_766600", "gene_names_uniprotkb": "Letm2", "gene_names_refseq": "6030453H13; D030041N04Rik; Letm2", "protein_names_uniprotkb": "LETM1 domain-containing protein LETM2, mitochondrial; LETM1 and EF-hand domain-containing protein 2; Leucine zipper-EF-hand-containing transmembrane protein 1-like", "protein_names_refseq": "LETM1 and EF-hand domain-containing protein 2; LETM1 domain-containing protein LETM2, mitochondrial isoform 1 precursor; LETM1 domain-containing protein LETM2, mitochondrial", "tax_id": 10090, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:270035)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;29237092", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0006851 mitochondrial calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TNU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00342-1", "uniprot_id": "LDHC_MOUSE", "mass": 35912.0, "length": 332, "protein_name": "L-lactate dehydrogenase C chain", "gene_name": "Ldhc", "organism": "Mouse", "refseq_name": "L-lactate dehydrogenase C chain", "refseq_ac": "NP_038608", "gene_names_uniprotkb": "Ldhc; Ldh-3; Ldh3", "gene_names_refseq": "LDH-C4; Ldh-3; Ldh-x; Ldh3; Ldhc4; Ldhc", "protein_names_uniprotkb": "L-lactate dehydrogenase C chain; 1.1.1.27; LDH testis subunit; LDH-C; LDH-X", "protein_names_refseq": "L-lactate dehydrogenase C chain; LDH testis subunit; LDH-C; lactate dehydrogenase 3, C chain, sperm specific; lactate dehydrogenase-X", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667)", "pathway": " (mmu:16833); (R-MMU-70268)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23055941;2439071;30590713;3619944;3754749;468772;468774;6343385;7429427", "class_list": "", "function": "Possible role in sperm motility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The LDHA protein level was remarkably decreased in Ldhc-deficient sperm, indicating that LDHC is required for LDHA expression in the sperm., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.27", "go_molecular_function": "GO:0004459 L-lactate dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:0030317 flagellated sperm motility;GO:0019244 lactate biosynthetic process from pyruvate;GO:0006089 lactate metabolic process;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P00342-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GQU6-1", "uniprot_id": "LIGO3_MOUSE", "mass": 64683.0, "length": 589, "protein_name": "Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3", "gene_name": "Lingo3", "organism": "Mouse", "refseq_name": "leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 precursor", "refseq_ac": "NP_001013780", "gene_names_uniprotkb": "Lingo3; Lrrn6b", "gene_names_refseq": "LERN2; Lingo3", "protein_names_uniprotkb": "Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine-rich repeat neuronal protein 6B", "protein_names_refseq": "leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 precursor; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; leucine-rich repeat neuronal protein 6B", "tax_id": 10090, "disease": "", "pathway": " (mmu:237403)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;33300544;40885482", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "E9QK50", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0051960 regulation of nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6GQU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60675-1", "uniprot_id": "LAMA2_MOUSE", "mass": 343815.0, "length": 3118, "protein_name": "Laminin subunit alpha-2", "gene_name": "Lama2", "organism": "Mouse", "refseq_name": "laminin subunit alpha-2 precursor", "refseq_ac": "NP_032507", "gene_names_uniprotkb": "Lama2", "gene_names_refseq": "5830440B04; Lama2; dy; mKIAA4087; merosin; mer", "protein_names_uniprotkb": "Laminin subunit alpha-2; Laminin M chain; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain", "protein_names_refseq": "dystrophia muscularis; laminin M chain; laminin subunit alpha-2 precursor; laminin subunit alpha-2; laminin-12 subunit alpha; laminin-2 subunit alpha; laminin-4 subunit alpha; merosin heavy chain", "tax_id": 10090, "disease": "autosomal recessive limb-girdle muscular dystrophy type 23 (Disease Ontology:DOID:0061132); congenital merosin-deficient muscular dystrophy 1A (Disease Ontology:DOID:0110636); myopia (Disease Ontology:DOID:11830); renovascular hypertension (Disease Ontology:DOID:1591); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:16773)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10022829;10619025;11304538;11829758;21750661;25428506;27526028;30084848;30899004;31219806;34428180;36288343;37507081;39927985;40021952;40885482;7795883;7874173;8345183", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 26, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 25, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 26, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 26, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 31, "disease_count": 5, "glyco_site_count": 37, "binding_glycan_count": 0, "secondary_ac_list": "F8VQ43;Q05003;Q64061", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction;GO:0043197 dendritic spine;GO:0043083 synaptic cleft", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0007155 cell adhesion;GO:0045785 positive regulation of cell adhesion;GO:0009887 animal organ morphogenesis;GO:0051149 positive regulation of muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 8.4, "record_id": "Q60675-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHZ8-1", "uniprot_id": "LEU7_MOUSE", "mass": 22444.0, "length": 209, "protein_name": "Leukemia-associated protein 7 homolog", "gene_name": "Dleu7", "organism": "Mouse", "refseq_name": "leukemia-associated protein 7 homolog", "refseq_ac": "NP_775595", "gene_names_uniprotkb": "Dleu7; Leu7", "gene_names_refseq": "Dleu7", "protein_names_uniprotkb": "Leukemia-associated protein 7 homolog; Deleted in lymphocytic leukemia 7 homolog", "protein_names_refseq": "deleted in lymphocytic leukemia 7 homolog; leukemia-associated protein 7 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:239133)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CHZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXQ3-1", "uniprot_id": "LRTM1_MOUSE", "mass": 38542.0, "length": 356, "protein_name": "Leucine-rich repeat and transmembrane domain-containing protein 1", "gene_name": "Lrtm1", "organism": "Mouse", "refseq_name": "leucine-rich repeat and transmembrane domain-containing protein 1 precursor", "refseq_ac": "NP_795894", "gene_names_uniprotkb": "Lrtm1", "gene_names_refseq": "A930016D02Rik; Lrtm1", "protein_names_uniprotkb": "Leucine-rich repeat and transmembrane domain-containing protein 1", "protein_names_refseq": "leucine-rich repeat and transmembrane domain-containing protein 1 precursor; leucine-rich repeat and transmembrane domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:319476)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20024584;21750661", "class_list": "", "function": "Reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm of mice with diaphragmatic defects., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BXQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4H7-1", "uniprot_id": "LONF3_MOUSE", "mass": 83656.0, "length": 753, "protein_name": "LON peptidase N-terminal domain and RING finger protein 3", "gene_name": "Lonrf3", "organism": "Mouse", "refseq_name": "LON peptidase N-terminal domain and RING finger protein 3", "refseq_ac": "NP_083170", "gene_names_uniprotkb": "Lonrf3; Rnf127", "gene_names_refseq": "4932412G04Rik; 5730439E01Rik; A830039N02Rik; Lonrf3; Rnf127", "protein_names_uniprotkb": "LON peptidase N-terminal domain and RING finger protein 3; RING finger protein 127", "protein_names_refseq": "LON peptidase N-terminal domain and RING finger protein 3; ring finger protein 127", "tax_id": 10090, "disease": "", "pathway": " (mmu:74365)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D4H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A5N8-1", "uniprot_id": "LMBL1_MOUSE", "mass": 91781.0, "length": 826, "protein_name": "Lethal(3)malignant brain tumor-like protein 1", "gene_name": "L3mbtl1", "organism": "Mouse", "refseq_name": "lethal(3)malignant brain tumor-like protein 1", "refseq_ac": "NP_001074807", "gene_names_uniprotkb": "L3mbtl1; Kiaa0681; L3mbtl; L3mbt", "gene_names_refseq": "C630004G01; L3mbtl1; L3mbtl; mKIAA0681", "protein_names_uniprotkb": "Lethal(3)malignant brain tumor-like protein 1; H-l(3)mbt protein; H-l(3)mbt; L(3)mbt protein homolog; L(3)mbt-like", "protein_names_refseq": "H-l(3)mbt protein; L(3)mbt protein homolog; lethal(3)malignant brain tumor-like protein 1", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:241764); (R-MMU-6804760)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20592034;21750661;25849281;29898393", "class_list": "", "function": "Generation and analysis of mice after disruption of L3MBTL1, [RefSeq, PubMed]; L3mbtl1 (lethal 3 malignant brain tumor-like 1), a polycomb chromatin reader, is downregulated by neuronal activity and is essential for synaptic response and downscaling. L3mbtl1 knockout neurons enhanced synaptic transmission and restored homeostatic downscaling., [RefSeq, PubMed]; L3mbtl1 loss-of-function was associated with significant decreases in depression and and anxiety in some of the behavioral paradigms. Publication Status: Online-Only, [RefSeq, PubMed]; Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5DU20", "ec_number_list": "", "go_molecular_function": "GO:0032093 SAM domain binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000793 condensed chromosome;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030097 hemopoiesis;GO:0006325 chromatin organization;GO:0045652 regulation of megakaryocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2A5N8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0B6-1", "uniprot_id": "LAMC3_MOUSE", "mass": 172322.0, "length": 1581, "protein_name": "Laminin subunit gamma-3", "gene_name": "Lamc3", "organism": "Mouse", "refseq_name": "laminin subunit gamma-3 precursor", "refseq_ac": "NP_035966", "gene_names_uniprotkb": "Lamc3", "gene_names_refseq": "1110064A23Rik; Lamc3", "protein_names_uniprotkb": "Laminin subunit gamma-3; Laminin-12 subunit gamma; Laminin-14 subunit gamma; Laminin-15 subunit gamma", "protein_names_refseq": "laminin subunit gamma-3 precursor; laminin subunit gamma-3; laminin-12 subunit gamma; laminin-14 subunit gamma; laminin-15 subunit gamma", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:23928)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10318827;15824114;21750661;25428506;30084848;30899004;31219806;34428180", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB, UniProtKB, UniProtKB]; Laminin gamma3 chain, located in murine basement membranes, binds to nidogen, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q4VAI3;Q9WTW6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005604 basement membrane;GO:1990340 laminin-15 complex;GO:1990338 laminin-14 complex;GO:0043261 laminin-12 complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0000902 cell morphogenesis;GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9R0B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2VDH3-1", "uniprot_id": "LRC38_MOUSE", "mass": 32343.0, "length": 298, "protein_name": "Leucine-rich repeat-containing protein 38", "gene_name": "Lrrc38", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 38 precursor", "refseq_ac": "NP_001156455", "gene_names_uniprotkb": "Lrrc38", "gene_names_refseq": "A230053A07Rik; Lrrc38", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 38; BK channel auxiliary gamma subunit LRRC38", "protein_names_refseq": "BK channel auxiliary gamma subunit LRRC38; BK channel auxilliary gamma subunit LRRC38; leucine-rich repeat-containing protein 38 precursor; leucine-rich repeat-containing protein 38", "tax_id": 10090, "disease": "", "pathway": " (mmu:242735)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A8J4;Q3TVH8;Q8BR15", "ec_number_list": "", "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity;GO:0099104 potassium channel activator activity", "go_cellular_component": "GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1903818 positive regulation of voltage-gated potassium channel activity;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80SV1-1", "uniprot_id": "LHPL1_MOUSE", "mass": 23787.0, "length": 220, "protein_name": "LHFPL tetraspan subfamily member 1 protein", "gene_name": "Lhfpl1", "organism": "Mouse", "refseq_name": "LHFPL tetraspan subfamily member 1 protein precursor", "refseq_ac": "NP_848135", "gene_names_uniprotkb": "Lhfpl1; Lhfpl", "gene_names_refseq": "Lhfpl1; Lhfp", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 1 protein; Lipoma HMGIC fusion partner-like 1 protein", "protein_names_refseq": "LHFPL tetraspan subfamily member 1 protein precursor; LHFPL tetraspan subfamily member 1 protein; lipoma HMGIC fusion partner-like 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:237091)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;26964900", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80SV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C6C9-1", "uniprot_id": "LEG1H_MOUSE", "mass": 38284.0, "length": 337, "protein_name": "Protein LEG1 homolog", "gene_name": "2310057J18Rik; Leg1", "organism": "Mouse", "refseq_name": "protein LEG1 homolog precursor", "refseq_ac": "NP_080612", "gene_names_uniprotkb": "2310057J18Rik; Leg1", "gene_names_refseq": "2210414P04Rik; 2310057J18Rik; Leg1", "protein_names_uniprotkb": "Protein LEG1 homolog", "protein_names_refseq": "UPF0762 protein C6orf58 homolog; protein LEG1 homolog precursor; protein LEG1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67719)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;35820727", "class_list": "", "function": "May be involved in early liver development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6D2;Q8C6D6;Q8VDJ0;Q9CPV8;Q9CQ55;Q9D6S4;Q9D745;Q9D775;Q9D7F4;Q9D865", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C6C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U4B4-1", "uniprot_id": "LIPN_MOUSE", "mass": 45744.0, "length": 400, "protein_name": "Lipase member N", "gene_name": "Lipn", "organism": "Mouse", "refseq_name": "lipase member N precursor", "refseq_ac": "NP_081616", "gene_names_uniprotkb": "Lipn; Lipl4", "gene_names_refseq": "2210418G03Rik; Lipl4; Lipn", "protein_names_uniprotkb": "Lipase member N; 3.1.1.13; 3.1.1.3; Lipase-like abhydrolase domain-containing protein 4", "protein_names_refseq": "lipase member N precursor; lipase member N; lipase-like abhydrolase domain-containing protein 4; lipase-like, ab-hydrolase domain containing 4", "tax_id": 10090, "disease": "autosomal recessive congenital ichthyosis 8 (Disease Ontology:DOID:0060717)", "pathway": " (mmu:70166); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20598663;21750661;25428506;34428180;35082200", "class_list": "", "function": "Lipase family member N is a novel target gene for CCAAT/enhancer-binding protein alpha in type 2 diabetic model mouse liver., [RefSeq, PubMed]; Plays a highly specific role in the last step of keratinocyte differentiation. Contains two distinct domains: the alpha/beta hydrolase fold and the abhydrolase-associated lipase region, also features the consensus sequence of the active site of a genuine lipase. May have an essential function in lipid metabolism of the most differentiated epidermal layers., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.32;3.1.1.34;3.1.1.3;3.1.1.26;3.1.1.5;3.1.1.23;3.1.1.79;3.1.1.4;3.1.1.13;3.1.1.6;3.1.1.-;3.1.1.71;3.1.1.1;3.1.1.116;2.3.1.51", "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0016298 lipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3U4B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGX3-1", "uniprot_id": "LRTM2_MOUSE", "mass": 41038.0, "length": 370, "protein_name": "Leucine-rich repeat and transmembrane domain-containing protein 2", "gene_name": "Lrtm2", "organism": "Mouse", "refseq_name": "leucine-rich repeat and transmembrane domain-containing protein 2 precursor", "refseq_ac": "NP_001165678", "gene_names_uniprotkb": "Lrtm2", "gene_names_refseq": "A230084J22; Lrtm2", "protein_names_uniprotkb": "Leucine-rich repeat and transmembrane domain-containing protein 2", "protein_names_refseq": "leucine-rich repeat and transmembrane domain-containing protein 2 precursor; leucine-rich repeat and transmembrane domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:211187)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;33300544;35615067;35820727", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BGX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCM4-1", "uniprot_id": "LIPT_MOUSE", "mass": 42146.0, "length": 373, "protein_name": "Lipoyl amidotransferase LIPT1, mitochondrial", "gene_name": "Lipt1", "organism": "Mouse", "refseq_name": "lipoyl amidotransferase LIPT1, mitochondrial precursor", "refseq_ac": "NP_001033007", "gene_names_uniprotkb": "Lipt1", "gene_names_refseq": "EG623661; Lipt1", "protein_names_uniprotkb": "Lipoyl amidotransferase LIPT1, mitochondrial; 2.3.1.-; 2.3.1.200; Lipoate biosynthesis protein; Lipoate-protein ligase; Lipoyl ligase; Lipoyltransferase 1", "protein_names_refseq": "lipoate biosynthesis protein; lipoate-protein ligase; lipoyl amidotransferase LIPT1, mitochondrial precursor; lipoyl amidotransferase LIPT1, mitochondrial; lipoyl ligase; lipoyltransferase 1, mitochondrial", "tax_id": 10090, "disease": "Leigh disease (Disease Ontology:DOID:3652)", "pathway": " (mmu:623661); (R-MMU-9857492)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Lipoyl amidotransferase that catalyzes the transfer of lipoyl moieties from lipoyl-protein H of the glycine cleavage system (lipoyl-GCSH) to E2 subunits of the pyruvate dehydrogenase complex (PDCE2). Unable to catalyze the transfer of octanoyl from octanoyl-GCSH to PDCE2 (By similarity). In vitro, it is also able to catalyze the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes but this reaction may not be physiologically relevant (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.168;2.3.1.12;2.3.1.-;2.3.1.200;2.3.1.61", "go_molecular_function": "GO:0016410 N-acyltransferase activity;GO:0017118 lipoyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0009249 protein lipoylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VCM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC16-1", "uniprot_id": "LRC14_MOUSE", "mass": 54969.0, "length": 493, "protein_name": "Leucine-rich repeat-containing protein 14", "gene_name": "Lrrc14", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 14", "refseq_ac": "NP_663446", "gene_names_uniprotkb": "Lrrc14; Kiaa0014", "gene_names_refseq": "E130306I01Rik; Lrrc14; mKIAA0014", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 14", "protein_names_refseq": "leucine-rich repeat-containing protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:223664); (R-MMU-9758274)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "19720120;21750661;25428506;27426725;30084848;31219806;31599954;34203471;34428180;37828378", "class_list": "", "function": "Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB., [UniProtKB, UniProtKB]; TLR signaling led to lower expression of LRRC14., [RefSeq, PubMed]; We define a small core bidirectional promoter that drives expression of the mouse genes Recql4, on one strand, and Lrrc14; a novel member of the LRR gene family, on the opposite strand, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6A0E7;Q80WK3", "ec_number_list": "", "go_molecular_function": "GO:0019900 kinase binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0034122 negative regulation of toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VC16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRC8-1", "uniprot_id": "LRC40_MOUSE", "mass": 68076.0, "length": 602, "protein_name": "Leucine-rich repeat-containing protein 40", "gene_name": "Lrrc40", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 40 isoform b", "refseq_ac": "NP_001276453", "gene_names_uniprotkb": "Lrrc40", "gene_names_refseq": "2610040E16Rik; Lrrc40", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 40", "protein_names_refseq": "leucine-rich repeat-containing protein 40 isoform b; leucine-rich repeat-containing protein 40", "tax_id": 10090, "disease": "", "pathway": " (mmu:67144)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;28528544;30084848;31219806;31599954;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q78WQ9;Q8BS83", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CRC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZL8-1", "uniprot_id": "LMO3_MOUSE", "mass": 16594.0, "length": 145, "protein_name": "LIM domain only protein 3", "gene_name": "Lmo3", "organism": "Mouse", "refseq_name": "LIM domain only protein 3 isoform 1", "refseq_ac": "NP_997105", "gene_names_uniprotkb": "Lmo3", "gene_names_refseq": "Lmo-3; Lmo3; Rbtn-3; Rbtn3", "protein_names_uniprotkb": "LIM domain only protein 3; LMO-3; Neuronal-specific transcription factor DAT1", "protein_names_refseq": "LIM domain only protein 3 isoform 1; LIM domain only protein 3; LIM only 3; neuronal-specific transcription factor DAT1", "tax_id": 10090, "disease": "", "pathway": " (mmu:109593)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37532091", "class_list": "", "function": "The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045600 positive regulation of fat cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035640 exploration behavior;GO:0070373 negative regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BZL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07797-1", "uniprot_id": "LG3BP_MOUSE", "mass": 64491.0, "length": 577, "protein_name": "Galectin-3-binding protein", "gene_name": "Lgals3bp", "organism": "Mouse", "refseq_name": "galectin-3-binding protein precursor", "refseq_ac": "NP_035280", "gene_names_uniprotkb": "Lgals3bp; Cycap; Mama", "gene_names_refseq": "90K; CyCAP; Lgals3bp; MAC-2BP; Ppicap; Tango10b", "protein_names_uniprotkb": "Galectin-3-binding protein; CyCAP; Cyp-C-associated protein; Lectin galactoside-binding soluble 3-binding protein; Protein MAMA", "protein_names_refseq": "cyp-C-associated protein; galectin-3-binding protein precursor; galectin-3-binding protein; mama; peptidylprolyl isomerase C-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:19039); (R-MMU-114608)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11465105;15507443;18250455;21750661;25428218;26495903;29187734;30899004;34638731;35984892;37191353;37453647;37828378;39062523;40885482;8119883;8341703", "class_list": "", "function": "CyC-AP is an important factor for the regulation of MMP-13 expression, [RefSeq, PubMed]; Physical Activity Attenuates the Obesity-Induced Dysregulated Expression of Brown Adipokines in Murine Interscapular Brown Adipose Tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity)., [UniProtKB, UniProtKB]; Using a mouse stasis model of venous thrombosis, we found that gal3bp and gal3 were localized on vein wall, red blood cells, platelets, and microparticles, whereas leukocytes expressed gal3 only., [RefSeq, PubMed]; Visualizing Galectin-3 Binding Protein Expression with ImmunoPET., [RefSeq, PubMed]; West Nile Virus-Induced Expression of Senescent Gene Lgals3bp Regulates Microglial Phenotype within Cerebral Cortex. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O35649;Q3U631;Q3U8K4;Q3UDL5", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q07797-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PT9-1", "uniprot_id": "KIF19_MOUSE", "mass": 111559.0, "length": 997, "protein_name": "Kinesin-like protein KIF19", "gene_name": "Kif19a; Kif19", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF19", "refseq_ac": "NP_001096085", "gene_names_uniprotkb": "Kif19a; Kif19; Kif19a", "gene_names_refseq": "Kif19a; Kif19", "protein_names_uniprotkb": "Kinesin-like protein KIF19", "protein_names_refseq": "KIF19A-like protein; N-8 kinesin; kinesin-like protein KIF19; oocyte-G1", "tax_id": 10090, "disease": "", "pathway": " (mmu:286942); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11416179;18727094;21750661;23168168;29802994;32683324", "class_list": "", "function": "AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals., [RefSeq, PubMed]; An open reading frame of 2,994 bp for a new gene (Oocyte-G1), which encodes a 997-residue protein, was cloned from an ovarian cDNA library (Oocyte-G1), [RefSeq, PubMed]; Findings suggest that KIF19A, a member of the kinesin superfamily, regulates ciliary length by depolymerizing microtubules at the tips of cilia, [RefSeq, PubMed]; Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips., [UniProtKB, PubMed]; Result showed that overexpression of Oocyte-G1 increased apoptosis in cultured cells. Oocyte-G1 transgenic mice also showed an increased apoptotic rate in male germ cells. Co-localization experiments revealed an interaction between Oocyte-G1 and Caspase-3 and suggest that Oocyte-G1 may promote male germ cell apoptosis through activating Caspase-3., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7DTH0", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0005871 kinesin complex;GO:0005930 axoneme", "go_biological_process": "GO:0060404 axonemal microtubule depolymerization;GO:0070462 plus-end specific microtubule depolymerization;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99PT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1P4-1", "uniprot_id": "LGR5_MOUSE", "mass": 99666.0, "length": 907, "protein_name": "Leucine-rich repeat-containing G protein-coupled receptor 5", "gene_name": "Lgr5", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing G-protein coupled receptor 5 precursor", "refseq_ac": "NP_034325", "gene_names_uniprotkb": "Lgr5; Fex; Gpr49", "gene_names_refseq": "FEX; Gpr49; Lgr5", "protein_names_uniprotkb": "Leucine-rich repeat-containing G protein-coupled receptor 5; G protein-coupled receptor 49; Orphan G protein-coupled receptor FEX", "protein_names_refseq": "G protein-coupled receptor 49; follicle expressed hormone; leucine-rich repeat-containing G-protein coupled receptor 5 precursor; orphan G-protein coupled receptor FEX", "tax_id": 10090, "disease": "ankyloglossia (Disease Ontology:DOID:0060604)", "pathway": " (mmu:14160); (R-MMU-4641263)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "15509778;17934449;18849992;21727895;21750661;22510880;25428506;29769720;30084848;31219806;9920770", "class_list": "", "function": "Physiological role of the LGR5 signaling system during embryonic development, [RefSeq, PubMed]; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]., [RefSeq]; Using two knock-in alleles, exclusive expression of Lgr5 in cycling columnar cells at the crypt base of the intesine is revealed, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1L2", "ec_number_list": "", "go_molecular_function": "GO:0016500 protein-hormone receptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0009994 oocyte differentiation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation;GO:0001942 hair follicle development;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z1P4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQ89-1", "uniprot_id": "LIX1L_MOUSE", "mass": 36606.0, "length": 337, "protein_name": "LIX1-like protein", "gene_name": "Lix1l", "organism": "Mouse", "refseq_name": "LIX1-like protein", "refseq_ac": "NP_001156642", "gene_names_uniprotkb": "Lix1l", "gene_names_refseq": "D130027M04Rik; Lix1l", "protein_names_uniprotkb": "LIX1-like protein", "protein_names_refseq": "LIX1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:280411)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34465730", "class_list": "", "function": "LIX1-like protein drives hepatic stellate cell activation to promote liver fibrosis by regulation of chemokine mRNA stability. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0030036 actin cytoskeleton organization;GO:0003174 mitral valve development;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BQ89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WV07-1", "uniprot_id": "LOXE3_MOUSE", "mass": 80473.0, "length": 711, "protein_name": "Hydroperoxide isomerase ALOXE3", "gene_name": "Aloxe3", "organism": "Mouse", "refseq_name": "hydroperoxide isomerase ALOXE3", "refseq_ac": "NP_035916", "gene_names_uniprotkb": "Aloxe3", "gene_names_refseq": "Aloxe3; e-LOX-3; eLOX-3", "protein_names_uniprotkb": "Hydroperoxide isomerase ALOXE3; 4.2.1.152; 5.4.4.7; Epidermal LOX-3; Epidermis-type lipoxygenase 3; Hydroperoxy dehydratase ALOXE3; Hydroperoxy icosatetraenoate dehydratase; Hydroperoxy icosatetraenoate isomerase; e-LOX-3; eLOX-3", "protein_names_refseq": "epidermal LOX-3; epidermis-type lipoxygenase 3; hydroperoxide isomerase ALOXE3; hydroperoxy dehydratase ALOXE3; hydroperoxy icosatetraenoate dehydratase; hydroperoxy icosatetraenoate isomerase", "tax_id": 10090, "disease": "autosomal recessive congenital ichthyosis 1 (Disease Ontology:DOID:0060656); autosomal recessive congenital ichthyosis 3 (Disease Ontology:DOID:0060711)", "pathway": " (mmu:23801); (R-MMU-2142712)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10366447;17045234;17403930;18320708;20530198;21750661;22832496;30135298", "class_list": "", "function": "Findings suggest that endogenous PPARgamma ligand(s) promoting adipocyte differentiation are generated via a baicalein-sensitive pathway involving the novel eLOX-3, [RefSeq, PubMed]; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity (PubMed:17045234). The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones (PubMed:17045234). In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (By similarity). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:22832496). In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (By similarity). Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (PubMed:20530198). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; Study demonstrated that the epidermal-type lipoxygenase, eLOX3 (encoded by its gene, Aloxe3) is a fasting-responsive hepatocyte effector that is sufficient to attenuate insulin resistance, weight gain, and hepatic fat deposition in dietary and genetically obese models, in part by activating hepatic PPARgamma. Publication Status: Online-Only, [RefSeq, PubMed]; The 12R-LOX-eLOX-3 pathway plays a key role in the process of epidermal barrier acquisition by affecting lipid metabolism, as well as protein processing., [RefSeq, PubMed]; The substrate preference of mouse eLOX3 and the unique occurrence of an 8S-LOX enzyme in mouse skin point to a potential LOX pathway for the production of epoxyalcohol in murine epidermal differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ASX3", "ec_number_list": "5.3.99.4;4.2.1.152;1.14.14.1;5.3.99.5;1.14.14.-;5.4.4.7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0106255 hydroperoxy icosatetraenoate isomerase activity;GO:0106256 hydroperoxy icosatetraenoate dehydratase activity;GO:0050486 intramolecular hydroxytransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0034440 lipid oxidation;GO:0046513 ceramide biosynthetic process;GO:0061436 establishment of skin barrier;GO:0006665 sphingolipid metabolic process;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WV07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR70-1", "uniprot_id": "LAGE3_MOUSE", "mass": 15824.0, "length": 148, "protein_name": "EKC/KEOPS complex subunit Lage3", "gene_name": "Lage3", "organism": "Mouse", "refseq_name": "EKC/KEOPS complex subunit Lage3", "refseq_ac": "NP_079686", "gene_names_uniprotkb": "Lage3; Itba2", "gene_names_refseq": "1110049G11Rik; Eso3; Itba2; Lage3", "protein_names_uniprotkb": "EKC/KEOPS complex subunit Lage3; ITBA2 protein homolog; L antigen family member 3", "protein_names_refseq": "EKC/KEOPS complex subunit Lage3; ITBA2 protein homolog", "tax_id": 10090, "disease": "Galloway-Mowat syndrome 2 (Disease Ontology:DOID:0080244)", "pathway": " (mmu:66192)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25153642;28805828", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0070525 tRNA threonylcarbamoyladenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CR70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35066-1", "uniprot_id": "KIF3C_MOUSE", "mass": 89973.0, "length": 796, "protein_name": "Kinesin-like protein KIF3C", "gene_name": "Kif3c", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF3C", "refseq_ac": "NP_032471", "gene_names_uniprotkb": "Kif3c", "gene_names_refseq": "Kif3c; mKIAA4058", "protein_names_uniprotkb": "Kinesin-like protein KIF3C", "protein_names_refseq": "N-4 kinesin; kinesin-like protein KIF3C", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:16570); (R-MMU-2132295); (R-MMU-5620924); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "16452087;25428506;29045878;31219806;32571914;33144324;33300544;34428180;36210013;9275178;9450952", "class_list": "", "function": "KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step., [RefSeq, PubMed]; Microtubule-based anterograde translocator for membranous organelles., [UniProtKB]; Results reveal that engineered homodimeric KIF3CC is targeted to the microtubule plus-end, acts as a potent catastrophe factor through an increase in microtubule catastrophe frequency, and does so by elimination of the dependence of the catastrophe rate on microtubule lifetime. Moreover, KIF3CC accelerates the catastrophe rate without altering the microtubule growth rate., [RefSeq, PubMed]; The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35229;Q3UH55", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0019894 kinesin binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35066-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54891-1", "uniprot_id": "LEG6_MOUSE", "mass": 34112.0, "length": 301, "protein_name": "Galectin-6", "gene_name": "Lgals6", "organism": "Mouse", "refseq_name": "galectin-6", "refseq_ac": "NP_034837", "gene_names_uniprotkb": "Lgals6", "gene_names_refseq": "Lgals6; galectin-6", "protein_names_uniprotkb": "Galectin-6; Gal-6", "protein_names_refseq": "gal-6; galectin-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:16857)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16786157;18385114;23360694;27427436;27936017;28011936;9446608;9446609", "class_list": "glycogene", "function": "Galectin-6 is a skin anti-microbial peptide that is modulated by the skin barrier and microbiome, [RefSeq, PubMed]; Patterns of galectin-4 and galectin-6 expression in the normal and the dextran sodium sulfate (DSS)-damaged digestive, [RefSeq, PubMed]; Results indicated that galectin-6 is expressed in the small intestine, colon, liver, kidney, spleen and heart and P19X1 cells of mouse but not in BW-5147 and 3T3 cell lines., [RefSeq, PubMed]; Results suggest that prion protein PrPC combined with galectin-3 and -6 can act as a receptor for murine leukemia virus (MuLV). Publication Status: Online-Only, [RefSeq, PubMed]; The example of a 2-million-year-old segmental duplication at the origin of the Lgals4 and Lgals6 genes in the mouse genome, is analysed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88352", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0002780 antibacterial peptide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54891-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01656-1", "uniprot_id": "KV3A3_MOUSE", "mass": 11904.0, "length": 111, "protein_name": "Ig kappa chain V-III region MOPC 70", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain V-III region MOPC 70", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "4162931", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01656-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11438-1", "uniprot_id": "LAMP1_MOUSE", "mass": 43865.0, "length": 406, "protein_name": "Lysosome-associated membrane glycoprotein 1", "gene_name": "Lamp1", "organism": "Mouse", "refseq_name": "lysosome-associated membrane glycoprotein 1 isoform 1 precursor", "refseq_ac": "NP_001304282", "gene_names_uniprotkb": "Lamp1; Lamp-1", "gene_names_refseq": "CD107a; LGP-120; LGP-A; Lamp-1; Lamp1; P2B; Perk", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 1; 120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; LAMP-1; LGP-120; LGP-A; Lysosomal membrane glycoprotein A; Lysosome-associated membrane protein 1; P2B", "protein_names_refseq": "120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B); Lamp I; lysosomal membrane glycoprotein 1; lysosomal membrane glycoprotein A; lysosome-associated membrane glycoprotein 1 isoform 1 precursor; lysosome-associated membrane protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16783); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10212251;15121881;16075062;16170054;16944957;19349973;19656770;2142158;22641697;2332434;23847195;2676155;27663661;30899004;32839608;33300544;3379044;37828378;40885482", "class_list": "glycogene", "function": "Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:15121881). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (By similarity). Also plays an important role in NK-cells cytotoxicity (PubMed:23847195). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (By similarity). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (By similarity). Also implicated in tumor cell metastasis (PubMed:2676155)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 16, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 16, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 17, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 17, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 39, "disease_count": 0, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "Q62020", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0008200 ion channel inhibitor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0007283 spermatogenesis;GO:0050821 protein stabilization;GO:0090160 Golgi to lysosome transport;GO:0043323 positive regulation of natural killer cell degranulation", "synthesized_glycan_count": 0, "hit_score": 7.9, "record_id": "P11438-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29752-1", "uniprot_id": "LALBA_MOUSE", "mass": 16260.0, "length": 143, "protein_name": "Alpha-lactalbumin", "gene_name": "Lalba", "organism": "Mouse", "refseq_name": "alpha-lactalbumin precursor", "refseq_ac": "NP_034809", "gene_names_uniprotkb": "Lalba", "gene_names_refseq": "Lalba; Lyzg", "protein_names_uniprotkb": "Alpha-lactalbumin; Lactose synthase B protein", "protein_names_refseq": "alpha-lactalbumin precursor; alpha-lactalbumin; lactose synthase B protein; lysozyme g", "tax_id": 10090, "disease": "gastroenteritis (Disease Ontology:DOID:2326); viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (mmu:16770); (R-MMU-5653890)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11419947;11485999;12927542;1398111;15141307;1555774", "class_list": "", "function": "A folding variant of alpha-lactalbumin has a role in lactating mammary gland apoptosis, [RefSeq, PubMed]; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003796 lysozyme activity;GO:0004461 lactose synthase activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0005989 lactose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P29752-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52955-1", "uniprot_id": "LBX1_MOUSE", "mass": 30262.0, "length": 282, "protein_name": "Transcription factor LBX1", "gene_name": "Lbx1", "organism": "Mouse", "refseq_name": "transcription factor LBX1", "refseq_ac": "NP_034821", "gene_names_uniprotkb": "Lbx1; Lbx1h", "gene_names_refseq": "Lbx1h; Lbx1", "protein_names_uniprotkb": "Transcription factor LBX1; Ladybird homeobox protein homolog 1", "protein_names_refseq": "lady bird-like homeobox 1 homolog; ladybird homeobox protein homolog 1; transcription factor LBX1", "tax_id": 10090, "disease": "congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731)", "pathway": " (mmu:16814)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10603359;12062039;15528197;16234809;8645601", "class_list": "", "function": "Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UN09;Q80XA3", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045665 negative regulation of neuron differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P52955-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59383-1", "uniprot_id": "LRRN4_MOUSE", "mass": 80489.0, "length": 733, "protein_name": "Leucine-rich repeat neuronal protein 4", "gene_name": "Lrrn4", "organism": "Mouse", "refseq_name": "leucine-rich repeat neuronal protein 4 precursor", "refseq_ac": "NP_796277", "gene_names_uniprotkb": "Lrrn4", "gene_names_refseq": "B430119L13Rik; Lrrn4; Nlrr4", "protein_names_uniprotkb": "Leucine-rich repeat neuronal protein 4; NLRR-4; Neuronal leucine-rich repeat protein 4", "protein_names_refseq": "NLRR-4; leucine-rich repeat neuronal protein 4 precursor; leucine-rich repeat neuronal protein 4; neuronal leucine rich repeat-4; neuronal leucine-rich repeat protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:320974)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15870286;19349973;23069668;23701859", "class_list": "", "function": "Lrrn4 is expressed in a subset of nociceptive neurons and might contribute to the maintenance of nociceptive circuits., [RefSeq, PubMed]; May play an important role in hippocampus-dependent long-lasting memory., [UniProtKB, PubMed]; Results suggest that NLRR4 plays a key role in hippocampus-dependent long-lasting memory, [RefSeq, PubMed]; The spatiotemporal expression pattern of Lrrn4 contributes to the development of synaptic function in the DRG neurons., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2ANX0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0008542 visual learning;GO:0007616 long-term memory", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P59383-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70193-1", "uniprot_id": "LRIG1_MOUSE", "mass": 119156.0, "length": 1091, "protein_name": "Leucine-rich repeats and immunoglobulin-like domains protein 1", "gene_name": "Lrig1", "organism": "Mouse", "refseq_name": "leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor", "refseq_ac": "NP_032403", "gene_names_uniprotkb": "Lrig1", "gene_names_refseq": "D6Bwg0781e; Img; LIG-1; Lrig1", "protein_names_uniprotkb": "Leucine-rich repeats and immunoglobulin-like domains protein 1; LIG-1", "protein_names_refseq": "integral membrane glycoprotein; leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor; leucine-rich repeats and immunoglobulin-like domains protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16206); (R-MMU-177929); (R-MMU-6807004)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12067728;30899004;31219806;34428180;39250533;8798419", "class_list": "", "function": "Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation., [UniProtKB, UniProtKB]; Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "E9QL89", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0060384 innervation;GO:0032474 otolith morphogenesis;GO:0007605 sensory perception of sound;GO:0022405 hair cycle process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P70193-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84750-1", "uniprot_id": "KVM5_MOUSE", "mass": 13251.0, "length": 121, "protein_name": "Ig kappa chain V region Mem5", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain V region Mem5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "12414967;34428180;35984892", "class_list": "", "function": "Anti-influenza H3N2 neuraminidase antibody., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P84750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97927-1", "uniprot_id": "LAMA4_MOUSE", "mass": 201819.0, "length": 1816, "protein_name": "Laminin subunit alpha-4", "gene_name": "Lama4", "organism": "Mouse", "refseq_name": "laminin subunit alpha-4 precursor", "refseq_ac": "NP_034811", "gene_names_uniprotkb": "Lama4", "gene_names_refseq": "Lama4", "protein_names_uniprotkb": "Laminin subunit alpha-4; Laminin-14 subunit alpha; Laminin-8 subunit alpha; Laminin-9 subunit alpha", "protein_names_refseq": "laminin [a]4; laminin subunit alpha-4 precursor; laminin subunit alpha-4; laminin-14 subunit alpha; laminin-8 subunit alpha; laminin-9 subunit alpha", "tax_id": 10090, "disease": "dilated cardiomyopathy 1JJ (Disease Ontology:DOID:0110438)", "pathway": " (mmu:16775); (R-MMU-3000157); (R-MMU-8874081); (R-MMU-9913351)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10893232;25428506;30899004;31219806;34428180;36210013;36288343;37507081;9034910;9049981;9151674;9219532;9346933", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 8, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 10, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 1, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "O88785;P70409;Q14BF2", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030155 regulation of cell adhesion;GO:0050873 brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P97927-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3URE9-1", "uniprot_id": "LIGO2_MOUSE", "mass": 68069.0, "length": 606, "protein_name": "Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2", "gene_name": "Lingo2", "organism": "Mouse", "refseq_name": "leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor", "refseq_ac": "NP_001159471", "gene_names_uniprotkb": "Lingo2; Lrrn6c", "gene_names_refseq": "B230217C06Rik; Lern3; Lingo2; Lrrn6c", "protein_names_uniprotkb": "Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2; Leucine-rich repeat neuronal protein 6C", "protein_names_refseq": "leucine rich repeat neuronal 6C; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2; leucine-rich repeat neuronal protein 6C", "tax_id": 10090, "disease": "", "pathway": " (mmu:242384)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;30899004;31562318;33300544;34428180;38380802;39443477;40885482", "class_list": "", "function": "Data show that trefoil factor 3 (TFF3) - leucine rich repeat receptor and nogo-interacting protein 2 (LINGO2) interactions disrupt EGFR-LINGO2 complexes resulting in enhanced epidermal growth factor receptor (EGFR) signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Roles of lncLingo2 and its derived miR-876-5p in the acquisition of opioid reinforcement., [RefSeq, PubMed]; Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLC0;Q8BZD4", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0097060 synaptic membrane", "go_biological_process": "GO:0051960 regulation of nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3URE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UV48-1", "uniprot_id": "LRC30_MOUSE", "mass": 33931.0, "length": 300, "protein_name": "Leucine-rich repeat-containing protein 30", "gene_name": "Lrrc30", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 30", "refseq_ac": "NP_001028512", "gene_names_uniprotkb": "Lrrc30", "gene_names_refseq": "Gm326; Lrrc30", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 30", "protein_names_refseq": "leucine-rich repeat-containing protein 30", "tax_id": 10090, "disease": "", "pathway": " (mmu:240131)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UV48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q571G4-1", "uniprot_id": "LIN54_MOUSE", "mass": 79566.0, "length": 749, "protein_name": "Protein lin-54 homolog", "gene_name": "Lin54", "organism": "Mouse", "refseq_name": "protein lin-54 homolog isoform 1", "refseq_ac": "NP_001108482", "gene_names_uniprotkb": "Lin54; Kiaa2037", "gene_names_refseq": "Lin54", "protein_names_uniprotkb": "Protein lin-54 homolog", "protein_names_refseq": "protein lin-54 homolog isoform 1; protein lin-54 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:231506); (R-MMU-1538133)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25605945;29187734;29237092;31219806;32782141;32848054;34428180;35822049;36852467;40021952;40885482;40997131", "class_list": "", "function": "Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 18, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 18, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 18, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "A0JLY2;Q3KQN0;Q3UYW5;Q8BMU8;Q8C107", "ec_number_list": "", "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0046872 metal ion binding;GO:0001067 transcription regulatory region nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090571 RNA polymerase II transcription repressor complex", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q571G4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGA3-1", "uniprot_id": "LAT4_MOUSE", "mass": 62430.0, "length": 568, "protein_name": "Large neutral amino acids transporter small subunit 4", "gene_name": "Slc43a2", "organism": "Mouse", "refseq_name": "large neutral amino acids transporter small subunit 4", "refseq_ac": "NP_001186212", "gene_names_uniprotkb": "Slc43a2; Lat4", "gene_names_refseq": "7630402D21Rik; Lat4; Slc43a2", "protein_names_uniprotkb": "Large neutral amino acids transporter small subunit 4; L-type amino acid transporter 4; Solute carrier family 43 member 2", "protein_names_refseq": "L-type amino L-acid transporter 4; L-type amino acid transporter 4; large neutral amino acids transporter small subunit 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:215113); (R-MMU-352230)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15659399;19144319;21183079;21750661;25428506;25480797;26740625;30084848;30379325;30779550;32470053;32879489;34428180", "class_list": "", "function": "Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Erratum:[Nature. 2026 Jan;649(8096):E3. doi: 10.1038/s41586-025-09845-8. PMID: 41388204], [RefSeq, PubMed]; In situ hybridization experiments show that LAT4 mRNA is restricted to the epithelial cells of the distal tubule and the collecting duct in the kidney. In the intestine, LAT4 is mainly present in the cells of the crypt., [RefSeq, PubMed]; LAT4 is subject to a circadian regulation by phosphorylation in the mouse small intestine, and this novel regulatory mechanism is suggested to play an important role in the diurnal regulation of amino acid absorption., [RefSeq, PubMed]; Mice lacking Lat4 display a slight intrauterine growth restriction, postnatal malnutrition and early death., [RefSeq, PubMed]; Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins. Publication Status: Online-Only, [RefSeq, PubMed]; Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine (PubMed:15659399, PubMed:25480797). Transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent (PubMed:25480797). Mediates the efflux of 3,3'-diiodo-L-thyronine (3,3'-T2) and 3-iodo-L-tyrosine (MIT) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5CD76", "ec_number_list": "", "go_molecular_function": "GO:0015188 L-isoleucine transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015190 L-leucine transmembrane transporter activity;GO:0015191 L-methionine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015820 L-leucine transport;GO:0015804 neutral amino acid transport;GO:0015807 L-amino acid transport;GO:0051956 negative regulation of amino acid transport;GO:0015823 phenylalanine transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CGA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61001-1", "uniprot_id": "LAMA5_MOUSE", "mass": 404054.0, "length": 3718, "protein_name": "Laminin subunit alpha-5", "gene_name": "Lama5", "organism": "Mouse", "refseq_name": "laminin subunit alpha-5 precursor", "refseq_ac": "NP_001074640", "gene_names_uniprotkb": "Lama5", "gene_names_refseq": "Lama5; [a]5; laminin-511; mKIAA0533", "protein_names_uniprotkb": "Laminin subunit alpha-5; Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha", "protein_names_refseq": "laminin subunit alpha-5 precursor; laminin subunit alpha-5; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha", "tax_id": 10090, "disease": "bent bone dysplasia syndrome 2 (Disease Ontology:DOID:0060993); nephrotic syndrome type 26 (Disease Ontology:DOID:0061193); familial nephrotic syndrome (Disease Ontology:DOID:2590); cystic kidney disease (Disease Ontology:DOID:2975)", "pathway": " (mmu:16776)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11304538;11829758;19349973;22517741;22872234;28179430;30059200;30899004;31219806;34428180;35822049;37507081;39053486;40021952;40885482;7499364", "class_list": "", "function": "A dispensable role of mural cell-derived laminin-alpha5 in intracerebral hemorrhage., [RefSeq, PubMed]; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Alpha-5 may be the major laminin alpha chain of adult epithelial and/or endothelial basal laminae. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signaling and PTK2B/PYK2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 8, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 18, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 19, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 19, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 19, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 32, "disease_count": 4, "glyco_site_count": 32, "binding_glycan_count": 0, "secondary_ac_list": "A2ABW7;Q9JHQ6", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0048018 receptor ligand activity;GO:0005201 extracellular matrix structural constituent;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0030155 regulation of cell adhesion;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 7.2, "record_id": "Q61001-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61789-1", "uniprot_id": "LAMA3_MOUSE", "mass": 366227.0, "length": 3330, "protein_name": "Laminin subunit alpha-3", "gene_name": "Lama3", "organism": "Mouse", "refseq_name": "laminin subunit alpha-3 isoform 3A precursor", "refseq_ac": "NP_001334390", "gene_names_uniprotkb": "Lama3", "gene_names_refseq": "Lama3B; Lama3; [a]3B", "protein_names_uniprotkb": "Laminin subunit alpha-3; Epiligrin subunit alpha; Kalinin subunit alpha; Laminin-5 subunit alpha; Laminin-6 subunit alpha; Laminin-7 subunit alpha; Nicein subunit alpha", "protein_names_refseq": "epiligrin subunit alpha; kalinin subunit alpha; laminin subunit alpha-3 isoform 3A precursor; laminin subunit alpha-3; laminin-5 subunit alpha; laminin-6 subunit alpha; laminin-7 subunit alpha; nicein subunit alpha; nicein, 150kDa", "tax_id": 10090, "disease": "junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (mmu:16774)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11829758;25428506;30084848;31599954;34428180;35820727;37635785;38012251;7665604;8012114;9151674", "class_list": "", "function": "A missense mutation in Lama3 causes androgen alopecia. Publication Status: Online-Only, [RefSeq, PubMed]; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB]; Heterozygous nonsense variants in laminin subunit 3alpha resulting in Ebstein's anomaly. Publication Status: Online-Only, [RefSeq, PubMed]; Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 7, "disease_count": 3, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "E9PUR4;O08751;Q61788;Q61966;Q9JHQ7", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005912 adherens junction;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:0098609 cell-cell adhesion;GO:0009887 animal organ morphogenesis;GO:0030334 regulation of cell migration;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q61789-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61897-1", "uniprot_id": "KT33B_MOUSE", "mass": 45864.0, "length": 404, "protein_name": "Keratin, type I cuticular Ha3-II", "gene_name": "Krt33b", "organism": "Mouse", "refseq_name": "keratin, type I cuticular Ha3-II", "refseq_ac": "NP_038598", "gene_names_uniprotkb": "Krt33b; Hka3; Krt1-3", "gene_names_refseq": "Ha3; Ha4; Krt1-3; Krt33b; mHa3", "protein_names_uniprotkb": "Keratin, type I cuticular Ha3-II; Hair keratin, type I Ha3; K33B; Keratin, type I cuticular Ha3; Keratin-33B", "protein_names_refseq": "K33B; hair keratin, type I Ha3; keratin complex 1, acidic, gene 3; keratin complex 1, gene 3; keratin, type I cuticular Ha3-II; keratin, type I cuticular Ha3; ortholog of keratin, hair, acidic, 3B KRTHA3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:16671); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "7514534", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5X8", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q61897-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62220-1", "uniprot_id": "KRA54_MOUSE", "mass": 21442.0, "length": 223, "protein_name": "Keratin-associated protein 5-4", "gene_name": "Krtap5-4", "organism": "Mouse", "refseq_name": "keratin-associated protein 5-4", "refseq_ac": "NP_056624", "gene_names_uniprotkb": "Krtap5-4", "gene_names_refseq": "Krtap5-4", "protein_names_uniprotkb": "Keratin-associated protein 5-4; UHS-Ser-2; Ultra high sulfur serine protein 2", "protein_names_refseq": "UHS-Ser-2; keratin-associated protein 5-4; ultra high sulfur serine protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:50775); (R-MMU-6805567)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2250030", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62220-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6JVL5-1", "uniprot_id": "LCN12_MOUSE", "mass": 22341.0, "length": 193, "protein_name": "Epididymal-specific lipocalin-12", "gene_name": "Lcn12", "organism": "Mouse", "refseq_name": "epididymal-specific lipocalin-12 precursor", "refseq_ac": "NP_084234", "gene_names_uniprotkb": "Lcn12", "gene_names_refseq": "9230102M18Rik; Lcn12", "protein_names_uniprotkb": "Epididymal-specific lipocalin-12", "protein_names_refseq": "epididymal-specific lipocalin-12 precursor; epididymal-specific lipocalin-12", "tax_id": 10090, "disease": "", "pathway": " (mmu:77701); (R-MMU-804914)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15363845", "class_list": "", "function": "Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6JVL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1C6-1", "uniprot_id": "LRIG3_MOUSE", "mass": 122688.0, "length": 1117, "protein_name": "Leucine-rich repeats and immunoglobulin-like domains protein 3", "gene_name": "Lrig3", "organism": "Mouse", "refseq_name": "leucine-rich repeats and immunoglobulin-like domains protein 3 precursor", "refseq_ac": "NP_796126", "gene_names_uniprotkb": "Lrig3; Kiaa3016", "gene_names_refseq": "9030421L11Rik; 9130004I02Rik; 9430095K15Rik; Lrig3; mKIAA3016", "protein_names_uniprotkb": "Leucine-rich repeats and immunoglobulin-like domains protein 3; LIG-3", "protein_names_refseq": "LIG-3; leucine-rich repeats and immunoglobulin-like domains protein 3 precursor; leucine-rich repeats and immunoglobulin-like domains protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:320398)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15203213;19004851;20126551;34338291;34428180", "class_list": "", "function": "Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation., [RefSeq, PubMed]; Mutually antagonistic interactions between Lrig3 and Ntn1 create complementary expression domains that define the future shape of the lateral canal. Removal of one copy of Ntn1 from Lrig3 mutants rescues the circling behavior and the canal malformation., [RefSeq, PubMed]; Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1., [UniProtKB, PubMed, PubMed]; Results suggest that although both Lrig1 and Lrig3 can interact with ErbB receptors in vitro, modulation of Neuregulin signaling is unlikely to contribute to Lrig3-dependent processes of inner ear morphogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPE6;Q8BRF0;Q8BS51;Q8C5E4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0032474 otolith morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6P1C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P566-1", "uniprot_id": "LIX1_MOUSE", "mass": 31915.0, "length": 282, "protein_name": "Protein limb expression 1 homolog", "gene_name": "Lix1", "organism": "Mouse", "refseq_name": "protein limb expression 1 homolog", "refseq_ac": "NP_079957", "gene_names_uniprotkb": "Lix1", "gene_names_refseq": "5730466L18Rik; Lix1", "protein_names_uniprotkb": "Protein limb expression 1 homolog", "protein_names_refseq": "limb expression 1 homolog; protein limb expression 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66643)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11731258;12638132;21846745", "class_list": "", "function": "Lix1 knockout mouse does not exhibit spinal muscular atrophy phenotype., [RefSeq, PubMed]; This protein is a marker for substantia nigra, cerebral cortex and hindbrain development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHY1;Q9CYH4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0097352 autophagosome maturation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P566-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P8U6-1", "uniprot_id": "LIPP_MOUSE", "mass": 51428.0, "length": 465, "protein_name": "Pancreatic triacylglycerol lipase", "gene_name": "Pnlip", "organism": "Mouse", "refseq_name": "pancreatic triacylglycerol lipase precursor", "refseq_ac": "NP_081201", "gene_names_uniprotkb": "Pnlip", "gene_names_refseq": "1810007A24Rik; PL; PTL; Pnlip", "protein_names_uniprotkb": "Pancreatic triacylglycerol lipase; 3.1.1.3; PL; PTL; Pancreatic lipase", "protein_names_refseq": "pancreatic triacylglycerol lipase precursor; pancreatic triacylglycerol lipase; pancreatic triglyceride lipase", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:69060); (R-MMU-192456); (R-MMU-975634)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10769148;15117679;21750661;36631248", "class_list": "", "function": "Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones., [UniProtKB, PubMed]; Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.32;3.1.1.34;3.1.1.3;3.1.1.26;3.1.1.5;3.1.1.23;3.1.1.79;3.1.1.4;3.1.1.13;3.1.1.1;3.1.1.-;3.1.1.6;3.1.1.88;3.1.1.67;3.1.1.116;3.1.1.28;2.3.1.51", "go_molecular_function": "GO:0016298 lipase activity;GO:0046872 metal ion binding;GO:0008970 phospholipase A1 activity;GO:0004806 triacylglycerol lipase activity;GO:0004465 lipoprotein lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006629 lipid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0030299 intestinal cholesterol absorption;GO:0034375 high-density lipoprotein particle remodeling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P8U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPI3-1", "uniprot_id": "LCOR_MOUSE", "mass": 47125.0, "length": 433, "protein_name": "Ligand-dependent corepressor", "gene_name": "Lcor", "organism": "Mouse", "refseq_name": "ligand-dependent corepressor isoform 2", "refseq_ac": "NP_742166", "gene_names_uniprotkb": "Lcor; Kiaa1795; Mlr2", "gene_names_refseq": "3110023F06Rik; A630025C20Rik; Gm340; Lcor; Mlr2; mKIAA1795", "protein_names_uniprotkb": "Ligand-dependent corepressor; LCoR; Mblk1-related protein 2", "protein_names_refseq": "Mblk1-related protein-2; ligand-dependent corepressor isoform 2; ligand-dependent corepressor; mblk1-related protein 2; transcription factor MLR2", "tax_id": 10090, "disease": "", "pathway": " (mmu:212391)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12560079;21750661;29663375;30084848;36852467", "class_list": "", "function": "Identification and characterization of Mlr2 a homolog of Mblk-1, a transcription factor from the honeybee brain; expressed in various tissues other than testis, [RefSeq, PubMed]; Long noncoding RNA H19 mediates LCoR to regulate the balance between osteogenic and adipogenic differentiation of mBMSCs in mice through sponging miR-188., [RefSeq, PubMed]; Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (By similarity). May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U302;Q5CZW7;Q80VA8;Q8BGT2;Q8C9Q0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0071392 cellular response to estradiol stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6ZPI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPY9-1", "uniprot_id": "LDOC1_MOUSE", "mass": 17546.0, "length": 151, "protein_name": "Protein LDOC1", "gene_name": "Ldoc1", "organism": "Mouse", "refseq_name": "protein LDOC1", "refseq_ac": "NP_001018097", "gene_names_uniprotkb": "Ldoc1; Gm366", "gene_names_refseq": "Gm366; Ldoc1; Mar7; Mart7; Rtl7; Sirh7", "protein_names_uniprotkb": "Protein LDOC1", "protein_names_refseq": "breast cancer, up-regulated 1; leucine zipper, down-regulated in cancer 1; protein LDOC1", "tax_id": 10090, "disease": "", "pathway": " (mmu:434784)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May have an important role in the development and/or progression of some cancers., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AV12", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0071222 cellular response to lipopolysaccharide;GO:0001893 maternal placenta development;GO:0071225 cellular response to muramyl dipeptide;GO:0060137 maternal process involved in parturition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TPY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810Z1-1", "uniprot_id": "LCN10_MOUSE", "mass": 20652.0, "length": 182, "protein_name": "Epididymal-specific lipocalin-10", "gene_name": "Lcn10", "organism": "Mouse", "refseq_name": "epididymal-specific lipocalin-10 precursor", "refseq_ac": "NP_828875", "gene_names_uniprotkb": "Lcn10", "gene_names_refseq": "9230112J07Rik; Lcn10", "protein_names_uniprotkb": "Epididymal-specific lipocalin-10", "protein_names_refseq": "epididymal-specific lipocalin-10 precursor; epididymal-specific lipocalin-10", "tax_id": 10090, "disease": "", "pathway": " (mmu:332578)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15363845;35757735;37392461", "class_list": "", "function": "Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway., [RefSeq, PubMed]; Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006954 inflammatory response;GO:0007507 heart development;GO:0032496 response to lipopolysaccharide;GO:0006950 response to stress;GO:0010165 response to X-ray", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q810Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGA3-1", "uniprot_id": "LRRT2_MOUSE", "mass": 58816.0, "length": 515, "protein_name": "Leucine-rich repeat transmembrane neuronal protein 2", "gene_name": "Lrrtm2", "organism": "Mouse", "refseq_name": "leucine-rich repeat transmembrane neuronal protein 2 precursor", "refseq_ac": "NP_821072", "gene_names_uniprotkb": "Lrrtm2; Kiaa0416", "gene_names_refseq": "C630011A14Rik; Lrrtm2; mKIAA0416", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane neuronal protein 2", "protein_names_refseq": "leucine-rich repeat transmembrane neuronal 2 protein; leucine-rich repeat transmembrane neuronal protein 2 precursor; leucine-rich repeat transmembrane neuronal protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:107065); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12676565;21750661;21788371;30262834;33300544;35662394", "class_list": "", "function": "Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the development and maintenance of excitatory synapses in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity)., [UniProtKB, UniProtKB]; The LRRTM2 acts redundantly to maintain excitatory synapses and that synapse elimination caused by the absence of LRRTM2 is promoted by synaptic activity and mediated by a postsynaptic Ca(2+)/CaM-dependent signaling pathway., [RefSeq, PubMed]; The Nrxn1beta-LRRTM2 interface involves Ca(2+)-mediated interactions and overlaps with the Nrxn-neuroligin interface. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80U08", "ec_number_list": "", "go_molecular_function": "GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0016020 membrane;GO:0060076 excitatory synapse", "go_biological_process": "GO:0050808 synapse organization;GO:0051965 positive regulation of synapse assembly;GO:0060291 long-term synaptic potentiation;GO:0002091 negative regulation of receptor internalization;GO:0099151 regulation of postsynaptic density assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BGA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGI7-1", "uniprot_id": "LRC39_MOUSE", "mass": 39061.0, "length": 337, "protein_name": "Leucine-rich repeat-containing protein 39", "gene_name": "Lrrc39", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 39 isoform 2", "refseq_ac": "NP_780622", "gene_names_uniprotkb": "Lrrc39", "gene_names_refseq": "2010005E21Rik; 9430028I06Rik; Lrrc39; Myomasp", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 39; Myomasp; Myosin-interacting M-band-associated stress-responsive protein", "protein_names_refseq": "leucine-rich repeat-containing protein 39 isoform 2; leucine-rich repeat-containing protein 39; myosin-interacting M-band-associated stress-responsive protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:109245)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20847312", "class_list": "", "function": "Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart., [UniProtKB, UniProtKB]; Reveal myomasp/LRRC39 as a previously unrecognized component of an M-band-associated signaling pathway that regulates cardiomyocyte gene expression in response to biomechanical stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031430 M band", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLB7-1", "uniprot_id": "LMBL3_MOUSE", "mass": 99137.0, "length": 883, "protein_name": "Lethal(3)malignant brain tumor-like protein 3", "gene_name": "L3mbtl3", "organism": "Mouse", "refseq_name": "lethal(3)malignant brain tumor-like protein 3 isoform 2", "refseq_ac": "NP_001334396", "gene_names_uniprotkb": "L3mbtl3; Mbt1", "gene_names_refseq": "L3mbtl3; MBT-1", "protein_names_uniprotkb": "Lethal(3)malignant brain tumor-like protein 3; L(3)mbt-like protein 3; MBT-1", "protein_names_refseq": "l(3)mbt-like 3; l(3)mbt-like protein 3; lethal(3)malignant brain tumor-like protein 3 isoform 2; lethal(3)malignant brain tumor-like protein 3", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (mmu:237339)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15889154;20173027;25605945;29030483;29691401;30442713;34428180;35820727", "class_list": "", "function": "Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (By similarity). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:30442713). Also involved in the regulation of ubiquitin-dependent degradation of methylated DNMT1 and E2F1 (By similarity). Required for normal maturation of myeloid progenitor cells., [UniProtKB, UniProtKB, PubMed, PubMed]; L3MBTL3 binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. Publication Status: Online-Only, [RefSeq, PubMed]; The direct binding of L3MBTL3 to the methylated SOX2 protein leads to the recruitment of the CRL4(DCAF5) ubiquitin E3 ligase to target SOX2 protein for ubiquitin-dependent proteolysis., [RefSeq, PubMed]; The mouse MBT-1 protein influences myelopoiesis by transiently enhancing p57(KIP2) expression levels., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGT0;Q641L7;Q6ZPI2;Q8C0G4", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042393 histone binding;GO:0140034 methylation-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0043249 erythrocyte maturation;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BLB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTN6-1", "uniprot_id": "LENG9_MOUSE", "mass": 52613.0, "length": 485, "protein_name": "Leukocyte receptor cluster member 9", "gene_name": "Leng9", "organism": "Mouse", "refseq_name": "leukocyte receptor cluster member 9", "refseq_ac": "NP_780738", "gene_names_uniprotkb": "Leng9", "gene_names_refseq": "9530024C23Rik; F630035L11Rik; Leng9", "protein_names_uniprotkb": "Leukocyte receptor cluster member 9", "protein_names_refseq": "leukocyte receptor cluster member 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:243813)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYM5;Q8BTG8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BTN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWJ4-1", "uniprot_id": "LRAD4_MOUSE", "mass": 33857.0, "length": 306, "protein_name": "Low-density lipoprotein receptor class A domain-containing protein 4", "gene_name": "Ldlrad4", "organism": "Mouse", "refseq_name": "low-density lipoprotein receptor class A domain-containing protein 4 isoform 1", "refseq_ac": "NP_766219", "gene_names_uniprotkb": "Ldlrad4; D18Ertd653e", "gene_names_refseq": "8230401C20Rik; A430083H02; A430108L08Rik; C18orf1; D18Ertd653e; D330030L18Rik; Ldlrad4", "protein_names_uniprotkb": "Low-density lipoprotein receptor class A domain-containing protein 4", "protein_names_refseq": "low-density lipoprotein receptor class A domain-containing protein 4 isoform 1; low-density lipoprotein receptor class A domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:52662)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;24627487;28888937", "class_list": "", "function": "Depletion of LDLRAD4 in HepG2 liver cancer cells inhibited tumorigenesis in nude mice. These results reveal an oncogenic role of LDLRAD4 in tumorigenesis through its association with Nedd4., [RefSeq, PubMed]; Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070412 R-SMAD binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0030336 negative regulation of cell migration;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0010719 negative regulation of epithelial to mesenchymal transition;GO:0060392 negative regulation of SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BWJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYR2-1", "uniprot_id": "LATS1_MOUSE", "mass": 126258.0, "length": 1129, "protein_name": "Serine/threonine-protein kinase LATS1", "gene_name": "Lats1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase LATS1 isoform 1", "refseq_ac": "NP_034820", "gene_names_uniprotkb": "Lats1; Warts", "gene_names_refseq": "Lats1", "protein_names_uniprotkb": "Serine/threonine-protein kinase LATS1; 2.7.11.1; Large tumor suppressor homolog 1; WARTS protein kinase", "protein_names_refseq": "WARTS protein kinase; large tumor suppressor homolog 1; large tumor supressor, homolog 1; serine/threonine-protein kinase LATS1 isoform 1; serine/threonine-protein kinase LATS1", "tax_id": 10090, "disease": "benign neoplasm (Disease Ontology:DOID:0060072); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:16798); (R-MMU-2028269)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21145499;21183079;31599954;32782141;37828378;39173637;9988268;9988269", "class_list": "", "function": "Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:21145499). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:21145499). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:21145499). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:9988269). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (By similarity). Involved in the control of p53 expression (By similarity). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (By similarity). May also play a role in endocrine function (By similarity). Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (By similarity). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "B2RY46;Q9Z0W4", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0098794 postsynapse", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0044546 NLRP3 inflammasome complex assembly;GO:0006468 protein phosphorylation;GO:0043065 positive regulation of apoptotic process;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BYR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZT5-1", "uniprot_id": "LRC19_MOUSE", "mass": 41573.0, "length": 364, "protein_name": "Leucine-rich repeat-containing protein 19", "gene_name": "Lrrc19", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 19 precursor", "refseq_ac": "NP_780514", "gene_names_uniprotkb": "Lrrc19", "gene_names_refseq": "9130022A01Rik; Lrrc19", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 19", "protein_names_refseq": "leucine-rich repeat-containing protein 19 precursor; leucine-rich repeat-containing protein 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:100061)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19679103;25026888;26776522;29461900;33501933;38172943", "class_list": "", "function": "Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis. Publication Status: Online-Only, [RefSeq, PubMed]; LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-zeta and PKCiota/lambda to Reduce Expression of ZO1, ZO3, and Occludin., [RefSeq, PubMed]; LRRC19 could be a potential therapeutic target for pressure ulcers., [RefSeq, PubMed]; LRRC19 deficiency impairs the gut immune system and host-microbiota interactions., [RefSeq, PubMed]; LRRC19 may play an important role in inducing innate immune responses in certain tissues such as the kidney., [RefSeq, PubMed]; Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines (PubMed:19679103, PubMed:25026888, PubMed:26776522). In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances (PubMed:25026888). In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (PubMed:26776522)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "B1AWG3;Q6P8J1", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0050727 regulation of inflammatory response;GO:0001817 regulation of cytokine production;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BZT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CB14-1", "uniprot_id": "LAS2_MOUSE", "mass": 59107.0, "length": 526, "protein_name": "Lung adenoma susceptibility protein 2", "gene_name": "4930503L19Rik; Las2", "organism": "Mouse", "refseq_name": "lung adenoma susceptibility protein 2 isoform 1 precursor", "refseq_ac": "NP_766555", "gene_names_uniprotkb": "4930503L19Rik; Las2", "gene_names_refseq": "4930503L19Rik; 9930107F24; Lars; Las2", "protein_names_uniprotkb": "Lung adenoma susceptibility protein 2", "protein_names_refseq": "lung adenoma susceptibility protein 2 isoform 1 precursor; lung adenoma susceptibility protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:269033)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19622765;21750661", "class_list": "", "function": "Might play a role in cell proliferation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNS5;Q8C2X0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CB14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CD19-1", "uniprot_id": "LANC3_MOUSE", "mass": 46475.0, "length": 420, "protein_name": "LanC-like protein 3", "gene_name": "Lancl3", "organism": "Mouse", "refseq_name": "lanC-like protein 3", "refseq_ac": "NP_775590", "gene_names_uniprotkb": "Lancl3", "gene_names_refseq": "6030463G20Rik; Lancl3", "protein_names_uniprotkb": "LanC-like protein 3", "protein_names_refseq": "lanC-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:236285)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25428506;28106097;30084848;34428180", "class_list": "", "function": "Very similar concentrations of lanthionine ketimine (0.5-2.5 nmol/g tissue) were found in LanCL1 knock-out, LanCL1/LanCL2/LanCL3 triple-knock-out and wild type (WT) mouse brains, suggesting that LanCL proteins are not involved in lanthionine biosynthesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AFA5;Q14BF1;Q8BRA2;Q8BRN8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0031179 peptide modification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CD19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K099-1", "uniprot_id": "LRIT1_MOUSE", "mass": 68464.0, "length": 624, "protein_name": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1", "gene_name": "Lrit1", "organism": "Mouse", "refseq_name": "leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 precursor", "refseq_ac": "NP_666357", "gene_names_uniprotkb": "Lrit1; Lrrc21; Pal", "gene_names_refseq": "Lrit1; Lrrc21", "protein_names_uniprotkb": "Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Leucine-rich repeat-containing protein 21; Photoreceptor-associated LRR superfamily protein; Retina-specific protein PAL", "protein_names_refseq": "leucine rich repeat containing 21; leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 precursor; leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; leucine-rich repeat-containing protein 21; photoreceptor-associated LRR superfamily protein; retina-specific protein PAL", "tax_id": 10090, "disease": "", "pathway": " (mmu:239037)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29590622", "class_list": "", "function": "Lrit1-deficient retinas exhibit an aberrant morphology of cone photoreceptor pedicles, as well as an impairment of signal transmission from cone photoreceptors to cone ON-bipolar cells. Authors demonstrated that Lrit1 interacts with Frmpd2, a photoreceptor scaffold protein, and with mGluR6, an ON-bipolar cell-specific glutamate receptor. GeneRIF: Lrit1 regulates the synaptic connection between cone photoreceptors and cone ON-bipolar cells. Lrit1-deficient retinas exhibit an aberrant morphology of cone photoreceptor pedicles, as well as an impairment of signal transmission from cone photoreceptors to cone ON-bipolar cells., [RefSeq, PubMed]; Photoreceptor synaptic protein essential for normal vision (PubMed:29590622). Involved in synapse formation in cone photoreceptor cells (PubMed:29590622)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXN3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030425 dendrite;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane;GO:0043083 synaptic cleft", "go_biological_process": "GO:0007601 visual perception;GO:0009416 response to light stimulus;GO:0007602 phototransduction;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2A6-1", "uniprot_id": "LIPM_MOUSE", "mass": 48254.0, "length": 422, "protein_name": "Lipase member M", "gene_name": "Lipm", "organism": "Mouse", "refseq_name": "lipase member M precursor", "refseq_ac": "NP_076392", "gene_names_uniprotkb": "Lipm; Lipl3", "gene_names_refseq": "4632427C23Rik; Lipl3; Lipm", "protein_names_uniprotkb": "Lipase member M; 3.1.1.-; Lipase-like abhydrolase domain-containing protein 3", "protein_names_refseq": "lipase member M precursor; lipase member M; lipase-like abhydrolase domain-containing protein 3; lipase-like, ab-hydrolase domain containing 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:78753); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJ28", "ec_number_list": "3.1.1.13;3.1.1.3;3.1.1.-", "go_molecular_function": "GO:0016298 lipase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K2A6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3W2-1", "uniprot_id": "LRC10_MOUSE", "mass": 31263.0, "length": 274, "protein_name": "Leucine-rich repeat-containing protein 10", "gene_name": "Lrrc10", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 10", "refseq_ac": "NP_666354", "gene_names_uniprotkb": "Lrrc10; Hrlrrp", "gene_names_refseq": "D330003I11Rik; Hrlrrp; Lrrc10; Serdin1", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 10; Heart-restricted leucine-rich repeat protein", "protein_names_refseq": "heart-restricted leucine-rich repeat protein; leucine-rich containing 10; leucine-rich repeat protein; leucine-rich repeat-containing protein 10", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:237560)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14751244;15830381;17626279;18781631;21345312;23751912;25428506;26608339", "class_list": "", "function": "Data demonstrate that the transcription factors Nkx2-5 and GATA4 cooperatively regulate cardiac-specific expression of Lrrc10., [RefSeq, PubMed]; GATA4 and MEF2C can both increase transcriptional activity of Lrrc10 promoter but that they do not work together in a synergistic fashion., [RefSeq, PubMed]; LRRC10 exhibits dynamic intracellular expression patterns in cardiomyocytes., [RefSeq, PubMed]; LRRC10 is required to maintain cardiac performance in response to pressure overload and suggest that dysregulated expression or mutation of LRRC10, [RefSeq, PubMed]; Lrrc10-null mice develop normally and exhibit no discernable phenotype, [RefSeq, PubMed]; May play important roles in cardiac development and/or cardiac function., [UniProtKB]; SERDIN1 is intimately integrated with the molecular pathways controlling cardiogenesis in vertebrates, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUL2", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005856 cytoskeleton;GO:0030017 sarcomere;GO:0030016 myofibril", "go_biological_process": "GO:0055013 cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K3W2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K406-1", "uniprot_id": "LGI3_MOUSE", "mass": 61818.0, "length": 548, "protein_name": "Leucine-rich repeat LGI family member 3", "gene_name": "Lgi3", "organism": "Mouse", "refseq_name": "leucine-rich repeat LGI family member 3 isoform 1 precursor", "refseq_ac": "NP_660254", "gene_names_uniprotkb": "Lgi3", "gene_names_refseq": "Lgi3", "protein_names_uniprotkb": "Leucine-rich repeat LGI family member 3; Leubrin; Leucine-rich glioma-inactivated protein 3", "protein_names_refseq": "leubrin; leucine-rich glioma-inactivated protein 3; leucine-rich repeat LGI family member 3 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:213469); (R-MMU-5682910)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16545924;18628660;18760330;19833108;21750661;33300544;35948005;38194969", "class_list": "", "function": "Data show that LGI3 localizes to the endocytic pathway and its accumulation is caused by endocytic perturbation., [RefSeq, PubMed]; May participate in the regulation of neuronal exocytosis., [UniProtKB, PubMed]; Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity., [RefSeq, PubMed]; The expression of mouse LGI3 (mLGI3) in adult and developing brain and analyzed the 5'-upstream transcriptional regulatory regions of mLGI3 gene., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0008021 synaptic vesicle;GO:0044224 juxtaparanode region of axon", "go_biological_process": "GO:0006887 exocytosis;GO:0017157 regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K406-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4Z0-1", "uniprot_id": "LGI2_MOUSE", "mass": 63006.0, "length": 550, "protein_name": "Leucine-rich repeat LGI family member 2", "gene_name": "Lgi2", "organism": "Mouse", "refseq_name": "leucine-rich repeat LGI family member 2 isoform 2 precursor", "refseq_ac": "NP_001297533", "gene_names_uniprotkb": "Lgi2; Kiaa1916", "gene_names_refseq": "Lgi2; mKIAA1916", "protein_names_uniprotkb": "Leucine-rich repeat LGI family member 2; Leucine-rich glioma-inactivated protein 2", "protein_names_refseq": "leucine-rich glioma-inactivated protein 2; leucine-rich repeat LGI family member 2 isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:246316); (R-MMU-5682910)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12217514;19833108;25428506;30679375", "class_list": "", "function": "LGI2 distribution in the vertical limb of the diagonal band and in putative hippocampal interneurons suggests that the function of these genes might be related to the generation of hippocampal theta rhythm., [RefSeq, PubMed]; Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80T76", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K4Z0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCD3-1", "uniprot_id": "LMA1L_MOUSE", "mass": 56312.0, "length": 505, "protein_name": "Protein ERGIC-53-like", "gene_name": "Lman1l", "organism": "Mouse", "refseq_name": "protein ERGIC-53-like precursor", "refseq_ac": "NP_954692", "gene_names_uniprotkb": "Lman1l; Ergl", "gene_names_refseq": "Lman1l; slamp", "protein_names_uniprotkb": "Protein ERGIC-53-like; ERGIC53-like protein; LMAN1-like protein; Lectin mannose-binding 1-like; Slamp; Sublingual acinar membrane protein", "protein_names_refseq": "ERGIC53-like protein; LMAN1-like protein; protein ERGIC-53-like precursor; protein ERGIC-53-like; sublingual acinar membrane protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:235416); (R-MMU-204005); (R-MMU-5694530)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15923361;25428506;35820727", "class_list": "glycogene", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4H2F4", "ec_number_list": "", "go_molecular_function": "GO:0005537 D-mannose binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VCD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VD1-1", "uniprot_id": "LEG12_MOUSE", "mass": 35460.0, "length": 314, "protein_name": "Galectin-12", "gene_name": "Lgals12", "organism": "Mouse", "refseq_name": "galectin-12 isoform 1", "refseq_ac": "NP_062389", "gene_names_uniprotkb": "Lgals12", "gene_names_refseq": "Grip1; Lgals12; gal-12", "protein_names_uniprotkb": "Galectin-12; Gal-12", "protein_names_refseq": "galectin-12 isoform 1; galectin-12; galectin-related inhibitor of proliferation 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56072)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11283015;11435439;15131127;21969596;26873172;32752134;36535362;37504513", "class_list": "glycogene", "function": "Ablation of Galectin-12 Inhibits Atherosclerosis through Enhancement of M2 Macrophage Polarization. Publication Status: Online-Only, [RefSeq, PubMed]; Binds lactose. May participate in the apoptosis of adipocytes., [UniProtKB]; Galectin 12 has a role in mitochondrial respiration, adiposity, and insulin resistance/glucose intolerance, [RefSeq, PubMed]; Galectin-12 modulates Kupffer cell polarization to alter the progression of nonalcoholic fatty liver disease., [RefSeq, PubMed]; Results suggest that galectin-12 is required for signal transduction that conveys hormone stimulation to the induction of adipogenic factors essential for adipocyte differentiation., [RefSeq, PubMed]; The Critical Role of Galectin-12 in Modulating Lipid Metabolism in Sebaceous Glands., [RefSeq, PubMed]; The activation of STAT3 was much higher in Gal12(-/-) macrophages activated by lipopolysaccharide, which was correlated with higher levels of IL-10. Adipocytes showed higher insulin sensitivity when treated with Gal12(-/-) macrophage-conditioned media than those treated with Gal12(+/+) macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UW90;Q8CCA4;Q8K2L7;Q9JKX2", "ec_number_list": "", "go_molecular_function": "GO:0030395 lactose binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0097193 intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91VD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W20-1", "uniprot_id": "LRC26_MOUSE", "mass": 35696.0, "length": 331, "protein_name": "Leucine-rich repeat-containing protein 26", "gene_name": "Lrrc26", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 26 precursor", "refseq_ac": "NP_666229", "gene_names_uniprotkb": "Lrrc26", "gene_names_refseq": "Lrrc26", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 26; BK channel auxiliary gamma subunit LRRC26", "protein_names_refseq": "BK channel auxiliary gamma subunit LRRC26; BK channel auxilliary gamma subunit LRRC26; leucine-rich repeat-containing protein 26 precursor; leucine-rich repeat-containing protein 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:227618)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "28416688;31800260;33431687", "class_list": "", "function": "Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium (By similarity)., [UniProtKB]; Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice., [RefSeq, PubMed]; LRRC26-containing BK channels are competent to contribute to resting K(+) efflux at normal cell membrane potentials with resting cytosolic Ca(2+) concentrations and likely play a critical physiological role in supporting normal secretory function in all secretory epithelial cells., [RefSeq, PubMed]; Roles of LRRC26 as an auxiliary gamma1-subunit of large-conductance Ca(2+)-activated K(+) channels in bronchial smooth muscle cells, is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUY1", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity;GO:0099104 potassium channel activator activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1903818 positive regulation of voltage-gated potassium channel activity;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91W20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924P3-1", "uniprot_id": "LCN8_MOUSE", "mass": 19866.0, "length": 175, "protein_name": "Epididymal-specific lipocalin-8", "gene_name": "Lcn8", "organism": "Mouse", "refseq_name": "epididymal-specific lipocalin-8 precursor", "refseq_ac": "NP_149157", "gene_names_uniprotkb": "Lcn8", "gene_names_refseq": "9230106L18Rik; EP17; Lcn5; Lcn8; mEP17", "protein_names_uniprotkb": "Epididymal-specific lipocalin-8; EP17; Epididymal 17 kDa lipocalin; mEP17", "protein_names_refseq": "epididymal 17 kDa lipocalin; epididymal-specific lipocalin-8 precursor; epididymal-specific lipocalin-8; lipocalin 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:78076)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11181548;12586764;12586765;33631677;34328598", "class_list": "", "function": "Data demonstrate that lipocalin EP17 (mEP17) spatial expression, regulation, and fate are different from that of the highly related mouse epididymal retinoic acid binding protein, [RefSeq, PubMed]; Deficiency for Lcn8 causes epididymal sperm maturation defects in mice., [RefSeq, PubMed]; Epididymal initial segment-specific Cre recombinase activity in Lcn8-Cre knock-in mice., [RefSeq, PubMed]; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis., [UniProtKB]; Results suggest that the 5.3mEP17(murine epididymal protein of 17 kilodaltons) fragment contains all the information required for spatial and temporal expression in the mouse epididymis, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q924P3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQW5-1", "uniprot_id": "LEG2_MOUSE", "mass": 14880.0, "length": 130, "protein_name": "Galectin-2", "gene_name": "Lgals2", "organism": "Mouse", "refseq_name": "galectin-2", "refseq_ac": "NP_079898", "gene_names_uniprotkb": "Lgals2", "gene_names_refseq": "2200008F12Rik; Lgals2", "protein_names_uniprotkb": "Galectin-2; Gal-2", "protein_names_refseq": "gal-2; galectin-2", "tax_id": 10090, "disease": "myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:107753)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17706016;17999373;26495903;26827730;27122052;29392834;33880624", "class_list": "glycogene", "function": "A comparative profiling has been started in the mouse as a model organism, combining sequence analysis, expression patterns and structural features in the cases of the homodimeric galectins-1, -2 and -7., [RefSeq, PubMed]; Alternative exon splicing and differential expression in pancreatic islets reveals candidate genes and pathways implicated in early diabetes development., [RefSeq, PubMed]; Analysis of the effect of low-temperature plasma on the expression of galectin-1, -2, and -3 in the healing skin compared with those of electrocoagulation conducted with a high-frequency electrical coagulator, [RefSeq, PubMed]; Galectin-2 (Gal-2) residues near cysteine residues C57 experienced significant chemical shift changes following S-nitrosylation., [RefSeq, PubMed]; Galectin-2 was present in nuclei of murine 3T3 fibroblasts., [RefSeq, PubMed]; Therefore, Cys(57) is suggested to be responsible for oxidative inactivation of the mGal-2 protein, and protection of the sulfhydryl group of the Cys(57) in mGal-2 by S-nitrosylation is likely important for maintaining mGal-2 protein function in an oxidative environment such as the gastrointestinal tract., [RefSeq, PubMed]; This protein binds beta-galactoside. Its physiological function is not yet known., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D800;Q9D862", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0016936 galactoside binding", "go_cellular_component": "GO:1990724 galectin complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0098609 cell-cell adhesion;GO:0050729 positive regulation of inflammatory response;GO:0043029 T cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CQW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXF0-1", "uniprot_id": "KYNU_MOUSE", "mass": 52325.0, "length": 464, "protein_name": "Kynureninase", "gene_name": "Kynu", "organism": "Mouse", "refseq_name": "kynureninase isoform 2", "refseq_ac": "NP_001276522", "gene_names_uniprotkb": "Kynu; KYNU", "gene_names_refseq": "4432411A05Rik; Kynu", "protein_names_uniprotkb": "Kynureninase; 3.7.1.3; L-kynurenine hydrolase", "protein_names_refseq": "L-kynurenine hydrolase; kynureninase isoform 2", "tax_id": 10090, "disease": "hydroxykynureninuria (Disease Ontology:DOID:0112257); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:70789); (R-MMU-71240)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15541637;21750661;25428506;28792876;30084848;34428180;34553380;37453647", "class_list": "", "function": "Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]; Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect., [RefSeq, PubMed]; Levels of mRNA for IDO (indoleamine 2,3-dioxygenase) and kynureninase, enzymes constituting the tryptophan degradation pathway, were found to be upregulated in the skin lesions of atopic dermatitis or psoriasis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.7.1.3", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0030429 kynureninase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0006569 L-tryptophan catabolic process;GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0009435 NAD+ biosynthetic process;GO:0019805 quinolinate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CXF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1E5-1", "uniprot_id": "LMBRL_MOUSE", "mass": 54958.0, "length": 489, "protein_name": "Protein LMBR1L", "gene_name": "Lmbr1l", "organism": "Mouse", "refseq_name": "protein LMBR1L isoform 1", "refseq_ac": "NP_083374", "gene_names_uniprotkb": "Lmbr1l; D15Ertd735e; Kiaa1174", "gene_names_refseq": "1110013E13Rik; D15Ertd735e; Limr; Lmbr1l", "protein_names_uniprotkb": "Protein LMBR1L; LIMR; Lipocalin-1-interacting membrane receptor; Uteroglobin receptor", "protein_names_refseq": "lipocalin-1-interacting membrane receptor; lipocalin-interacting membrane receptor; protein LMBR1L isoform 1; protein LMBR1L; uteroglobin receptor", "tax_id": 10090, "disease": "bone development disease (Disease Ontology:DOID:0080006)", "pathway": " (mmu:74775)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31073040;31219806;35146515", "class_list": "", "function": "LMBR1L has an essential function during lymphopoiesis and lymphoid activation, acting as a negative regulator of the Wnt/beta-catenin pathway., [RefSeq, PubMed]; LMBR1L regulates the proliferation and migration of endothelial cells through Norrin/beta-catenin signaling., [RefSeq, PubMed]; Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (PubMed:31073040). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (PubMed:31073040). Acts as a LCN1 receptor and can mediate its endocytosis (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD82;Q69ZP7", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0060218 hematopoietic stem cell differentiation;GO:0006898 receptor-mediated endocytosis;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D1E5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D267-1", "uniprot_id": "LCN9_MOUSE", "mass": 20503.0, "length": 178, "protein_name": "Epididymal-specific lipocalin-9", "gene_name": "Lcn9", "organism": "Mouse", "refseq_name": "epididymal-specific lipocalin-9 precursor", "refseq_ac": "NP_084235", "gene_names_uniprotkb": "Lcn9", "gene_names_refseq": "9230102I19Rik; Lcn9", "protein_names_uniprotkb": "Epididymal-specific lipocalin-9; MUP-like lipocalin", "protein_names_refseq": "MUP-like lipocalin; epididymal-specific lipocalin-9 precursor; epididymal-specific lipocalin-9", "tax_id": 10090, "disease": "", "pathway": " (mmu:77704); (R-MMU-804914)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15363845;20173027;34310634", "class_list": "", "function": "A novel mouse line with epididymal initial segment-specific expression of Cre recombinase driven by the endogenous Lcn9 promoter. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZC4", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3I6-1", "uniprot_id": "KRA71_MOUSE", "mass": 9516.0, "length": 87, "protein_name": "Keratin-associated protein 7-1", "gene_name": "Krtap7-1", "organism": "Mouse", "refseq_name": "keratin-associated protein 7-1", "refseq_ac": "NP_082047", "gene_names_uniprotkb": "Krtap7-1; Kap7.1; Krtap7.1", "gene_names_refseq": "5430433J05Rik; Krtap7-1", "protein_names_uniprotkb": "Keratin-associated protein 7-1; High glycine-tyrosine keratin-associated protein 7.1", "protein_names_refseq": "high glycine-tyrosine keratin-associated protein 7.1; keratin-associated protein 7-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71363)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15385554;25428506", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]; Krtap16 is a hair keratin-associated protein gene complex regulated by Hoxc13; localized to chromosome 16, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D3I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7P0-1", "uniprot_id": "KRA33_MOUSE", "mass": 10531.0, "length": 99, "protein_name": "Keratin-associated protein 3-3", "gene_name": "Krtap3-3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Krtap3-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin-associated protein 3-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-6805567)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D7P0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7X1-1", "uniprot_id": "KCTD4_MOUSE", "mass": 29978.0, "length": 259, "protein_name": "BTB/POZ domain-containing protein KCTD4", "gene_name": "Kctd4", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein KCTD4", "refseq_ac": "NP_080490", "gene_names_uniprotkb": "Kctd4", "gene_names_refseq": "2210017A09Rik; Kctd4", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD4", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67516)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCQ3;Q9CYK4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D7X1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB98-1", "uniprot_id": "LENG1_MOUSE", "mass": 30469.0, "length": 261, "protein_name": "Leukocyte receptor cluster member 1 homolog", "gene_name": "Leng1", "organism": "Mouse", "refseq_name": "leukocyte receptor cluster member 1 homolog", "refseq_ac": "NP_081479", "gene_names_uniprotkb": "Leng1", "gene_names_refseq": "1500001K17Rik; Leng1", "protein_names_uniprotkb": "Leukocyte receptor cluster member 1 homolog", "protein_names_refseq": "leukocyte receptor cluster member 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69757); (R-MMU-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DB98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI60-1", "uniprot_id": "LRAT_MOUSE", "mass": 25820.0, "length": 231, "protein_name": "Lecithin retinol acyltransferase", "gene_name": "Lrat", "organism": "Mouse", "refseq_name": "lecithin retinol acyltransferase", "refseq_ac": "NP_076113", "gene_names_uniprotkb": "Lrat", "gene_names_refseq": "1300010A18Rik; Lrat", "protein_names_uniprotkb": "Lecithin retinol acyltransferase; 2.3.1.135; Phosphatidylcholine--retinol O-acyltransferase; Phosphatidylcholine-retinol-O-acyltransferase", "protein_names_refseq": "lecithin retinol acyltransferase; phosphatidylcholine--retinol O-acyltransferase", "tax_id": 10090, "disease": "Leber congenital amaurosis 14 (Disease Ontology:DOID:0110188); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:79235); (R-MMU-2453902); (R-MMU-975634)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11108736;14684738;16115871;16174770;17114808;18544127;20628054;25416279;28758396;30084848", "class_list": "", "function": "LRAT has a role in retinoid absorption and storage, [RefSeq, PubMed]; LRAT-/- mice are much more susceptible to vitamin A deficiency and should be an excellent animal model of vitamin A deficiency, [RefSeq, PubMed]; Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver, [RefSeq, PubMed]; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (PubMed:28758396). LRAT plays a critical role in vision (By similarity). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (By similarity). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (PubMed:25416279)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.135", "go_molecular_function": "GO:0016416 O-palmitoyltransferase activity;GO:0047173 phosphatidylcholine-retinol O-acyltransferase activity;GO:0019841 retinol binding;GO:0001972 retinoic acid binding;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:0032370 positive regulation of lipid transport;GO:0001523 retinoid metabolic process;GO:0009617 response to bacterium;GO:0042572 retinol metabolic process;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JI60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIA1-1", "uniprot_id": "LGI1_MOUSE", "mass": 63644.0, "length": 557, "protein_name": "Leucine-rich glioma-inactivated protein 1", "gene_name": "Lgi1", "organism": "Mouse", "refseq_name": "leucine-rich glioma-inactivated protein 1 precursor", "refseq_ac": "NP_064674", "gene_names_uniprotkb": "Lgi1", "gene_names_refseq": "Lgi1", "protein_names_uniprotkb": "Leucine-rich glioma-inactivated protein 1", "protein_names_refseq": "leucine-rich glioma-inactivated protein 1 precursor; leucine-rich glioma-inactivated protein 1", "tax_id": 10090, "disease": "familial temporal lobe epilepsy 1 (Disease Ontology:DOID:0060748); epilepsy (Disease Ontology:DOID:1826); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725)", "pathway": " (mmu:56839); (R-MMU-5682910)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10920229;15857855;16452087;16787412;18563303;18974846;19833108;21750661;26269648;30899004;33300544;34428180;35727946;37863654;40021952;40684658", "class_list": "", "function": "Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1., [RefSeq, PubMed]; Reduce levels of secreted LGI1 is associated with autosomal dominant partial epilepsy with auditory features, [RefSeq, PubMed]; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity)., [UniProtKB, UniProtKB]; Rescue of Normal Excitability in LGI1-Deficient Epileptic Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; This study was the first to determine a specific profile of Lgi1 gene expression during central nervous system development, which suggests a possible inhibitory function in latter stages of development., [RefSeq, PubMed]; Two protein isoforms encoded by LGI1/epitempin are differentially expressed in mouse brain: the 60-kDa form is detected in the microsomal fraction, while the 65-kDa product is found in the cytosolic fraction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JFT0", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0031175 neuron projection development;GO:0007411 axon guidance;GO:0050806 positive regulation of synaptic transmission;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q9JIA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUN8-1", "uniprot_id": "LBX2_MOUSE", "mass": 20917.0, "length": 195, "protein_name": "Transcription factor LBX2", "gene_name": "Lbx2", "organism": "Mouse", "refseq_name": "transcription factor LBX2", "refseq_ac": "NP_034822", "gene_names_uniprotkb": "Lbx2; Lbx2h", "gene_names_refseq": "Lbx2h; Lbx2", "protein_names_uniprotkb": "Transcription factor LBX2; Ladybird homeobox 2; Ladybird homeobox protein homolog 2", "protein_names_refseq": "lady bird-like homeobox 2 homolog; ladybird homeobox homolog 2; ladybird homeobox protein homolog 2; transcription factor LBX2", "tax_id": 10090, "disease": "", "pathway": " (mmu:16815)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10473138;11386758;17492753;20820887", "class_list": "", "function": "LBX2 has a role in ovarian maturation and folliculogenesis., [RefSeq, PubMed]; Pax3 is required for Lbx2 expression in affected neural crest-derived tissues, [RefSeq, PubMed]; Transcription factor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32M12", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042692 muscle cell differentiation;GO:2000052 positive regulation of non-canonical Wnt signaling pathway;GO:1904105 positive regulation of convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WUN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVG5-1", "uniprot_id": "LIPG_MOUSE", "mass": 56629.0, "length": 500, "protein_name": "Endothelial lipase", "gene_name": "Lipg", "organism": "Mouse", "refseq_name": "endothelial lipase precursor", "refseq_ac": "NP_034850", "gene_names_uniprotkb": "Lipg", "gene_names_refseq": "3110013K01Rik; EL; Lipg; lipase; mEDL", "protein_names_uniprotkb": "Endothelial lipase; 3.1.1.32; 3.1.1.3; EDL; Endothelial cell-derived lipase; Phospholipase A1", "protein_names_refseq": "EDL; endothelial cell-derived lipase; endothelial lipase precursor; endothelial lipase; lipase, endothelial; lipose, endothelial; phospholipase A1", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); cardiovascular system disease (Disease Ontology:DOID:1287); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16891); (R-MMU-8964058)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10318835;12569156;12569160;12569161;34197964;37655967", "class_list": "", "function": "Endothelial lipase has a role in HDL metabolism [review] Review article, [RefSeq, PubMed]; Endothelial lipase has a role in regulating HDL cholesterol levels, [RefSeq, PubMed]; Endothelial lipase has a role in regulating HDL levels, [RefSeq, PubMed]; Exerts both phospholipase and triglyceride lipase activities (By similarity). More active as a phospholipase than a triglyceride lipase (By similarity). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (By similarity). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (By similarity)., [UniProtKB, UniProtKB]; Functional involvement of endothelial lipase in hepatitis B virus infection. Publication Status: Online-Only, [RefSeq, PubMed]; Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDU2", "ec_number_list": "3.1.1.32;3.1.1.34;3.1.1.3;3.1.1.26;3.1.1.5;3.1.1.23;3.1.1.79;3.1.1.4;3.1.1.13;3.1.1.6;3.1.1.-;3.1.1.111;3.1.1.118;2.3.1.-;3.1.1.116;2.3.1.51", "go_molecular_function": "GO:0008201 heparin binding;GO:0004620 phospholipase activity;GO:0008970 phospholipase A1 activity;GO:0004806 triacylglycerol lipase activity;GO:0004465 lipoprotein lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0009986 cell surface", "go_biological_process": "GO:0007584 response to nutrient;GO:0006633 fatty acid biosynthetic process;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis;GO:0043691 reverse cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WVG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14C37-1", "uniprot_id": "LEMD1_MOUSE", "mass": 14258.0, "length": 129, "protein_name": "LEM domain-containing protein 1", "gene_name": "Lemd1", "organism": "Mouse", "refseq_name": "LEM domain-containing protein 1 isoform 4", "refseq_ac": "NP_001028422", "gene_names_uniprotkb": "Lemd1", "gene_names_refseq": "4930540I23Rik; 6430514M23Rik; LEMP-1; Lemd1", "protein_names_uniprotkb": "LEM domain-containing protein 1", "protein_names_refseq": "LEM domain-containing protein 1 isoform 4; LEM domain-containing protein 1", "tax_id": 10090, "disease": "Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726)", "pathway": " (mmu:213409)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q14C37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CW02-1", "uniprot_id": "LY6C1_MOUSE", "mass": 14193.0, "length": 131, "protein_name": "Lymphocyte antigen 6C1", "gene_name": "Ly6c1", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6C1 isoform 1 precursor", "refseq_ac": "NP_001238984", "gene_names_uniprotkb": "Ly6c1", "gene_names_refseq": "Ly-6C1; Ly-6C; Ly6c1; Ly6c", "protein_names_uniprotkb": "Lymphocyte antigen 6C1; Ly-6C1", "protein_names_refseq": "Lymphocyte antigen Ly-6C; lymphocyte antigen 6 complex, locus C1; lymphocyte antigen 6 complex, locus C; lymphocyte antigen 6C1 isoform 1 precursor; lymphocyte antigen 6C1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17067)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;3356904;34428180;37075114", "class_list": "", "function": "Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09568;Q58E40;Q8C2D8;Q91XG0", "ec_number_list": "", "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045202 synapse;GO:0009897 external side of plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0CW02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63006-1", "uniprot_id": "LHX1_MOUSE", "mass": 44780.0, "length": 406, "protein_name": "LIM/homeobox protein Lhx1", "gene_name": "Lhx1", "organism": "Mouse", "refseq_name": "LIM/homeobox protein Lhx1", "refseq_ac": "NP_032524", "gene_names_uniprotkb": "Lhx1; Lim-1; Lim1", "gene_names_refseq": "Lhx1; Lim1", "protein_names_uniprotkb": "LIM/homeobox protein Lhx1; Homeobox protein Lim-1; LIM homeobox protein 1", "protein_names_refseq": "LIM homeo box protein 1; LIM/homeobox protein Lhx1; homeobox protein Lim-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16869)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10337615;21750661;7904966;7909459;8793615;8918878;9468533", "class_list": "", "function": "Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P36199", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0060429 epithelium development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007267 cell-cell signaling;GO:0021510 spinal cord development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P63006-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V01-1", "uniprot_id": "MBOA5_MOUSE", "mass": 56147.0, "length": 487, "protein_name": "Lysophospholipid acyltransferase 5", "gene_name": "Lpcat3", "organism": "Mouse", "refseq_name": "lysophospholipid acyltransferase 5", "refseq_ac": "NP_660112", "gene_names_uniprotkb": "Lpcat3; Grcc3f; Mboat5; Oact5", "gene_names_refseq": "C3f; Grcc3f; Lpcat3; Lpcat; Lpeat; Lplat5; Lpsat; Mboat5; Moact5; Oact5; PTG", "protein_names_uniprotkb": "Lysophospholipid acyltransferase 5; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; 2.3.1.-; 2.3.1.23; 2.3.1.n6; 2.3.1.n7; LPCAT; LPEAT; LPLAT 5; LPSAT; Lyso-PC acyltransferase 3; Lyso-PC acyltransferase; Lyso-PE acyltransferase; Lyso-PS acyltransferase; Lysophosphatidylcholine acyltransferase 3; Lysophosphatidylcholine acyltransferase; Lysophosphatidylethanolamine acyltransferase; Lysophosphatidylserine acyltransferase; Membrane-bound O-acyltransferase domain-containing protein 5; O-acyltransferase domain-containing protein 5; mLPCAT3", "protein_names_refseq": "1-acylglycerophosphoserine O-acyltransferase; LPC acyltransferase 3; O-acyltransferase domain-containing protein 5; lyso-PC acyltransferase 3; lyso-PE acyltransferase; lyso-PS acyltransferase; lysophosphatidylethanolamine acyltransferase; lysophosphatidylserine acyltransferase; lysophospholipid acyltransferase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:14792); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "18287005;21750661;22511767;23208369;24206663;25806685;25898003;26833026;28846071;29395055;31219806;34428180;38519981;40997131;9445485", "class_list": "", "function": "Hepatic LPCAT3 modulates VLDL production by regulating LysoPC levels and MTP expression., [RefSeq, PubMed]; Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis. Publication Status: Online-Only, [RefSeq, PubMed]; It is possible that enhanced phospholipid remodeling by LPCAT3 may be associated with adipocyte differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18287005, PubMed:25898003). Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18287005, PubMed:25898003). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs (PubMed:18287005). Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (PubMed:18287005). Acts as a major LPC O-acyltransferase in liver and intestine (PubMed:25898003, PubMed:26833026). As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (PubMed:25806685). Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (PubMed:28846071). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation (PubMed:24206663). Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (PubMed:24206663). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (PubMed:26833026). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (PubMed:29395055)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1B362;O35131;Q8BNH6", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;2.3.1.51;2.3.1.67;2.3.1.25;2.3.1.121;2.3.1.n6;2.3.1.n7;2.3.1.-", "go_molecular_function": "GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0071617 lysophospholipid acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity;GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097006 regulation of plasma lipoprotein particle levels;GO:0090158 endoplasmic reticulum membrane organization;GO:0045540 regulation of cholesterol biosynthetic process;GO:0050728 negative regulation of inflammatory response;GO:0006656 phosphatidylcholine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q91V01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UU94-1", "uniprot_id": "MANS4_MOUSE", "mass": 36857.0, "length": 337, "protein_name": "MANSC domain-containing protein 4", "gene_name": "Mansc4", "organism": "Mouse", "refseq_name": "MANSC domain-containing protein 4 precursor", "refseq_ac": "NP_001030075", "gene_names_uniprotkb": "Mansc4; Gm5887", "gene_names_refseq": "A430079E08; EG545893; Gm5887; Mansc4", "protein_names_uniprotkb": "MANSC domain-containing protein 4", "protein_names_refseq": "MANSC domain-containing protein 4 precursor; MANSC domain-containing protein 4; MANSC domain-containing protein ENSP00000370673 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:545893)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2KFS6", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0060429 epithelium development;GO:0030198 extracellular matrix organization;GO:0008544 epidermis development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UU94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2D7-1", "uniprot_id": "MBD4_MOUSE", "mass": 62578.0, "length": 554, "protein_name": "Methyl-CpG-binding domain protein 4", "gene_name": "Mbd4", "organism": "Mouse", "refseq_name": "methyl-CpG-binding domain protein 4 isoform 1", "refseq_ac": "NP_034904", "gene_names_uniprotkb": "Mbd4", "gene_names_refseq": "Mbd4; Med1", "protein_names_uniprotkb": "Methyl-CpG-binding domain protein 4; 3.2.2.-; Methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase", "protein_names_refseq": "methyl-CpG-binding domain protein 4 isoform 1; methyl-CpG-binding protein MBD4; mismatch-specific DNA N-glycosylase", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); lung cancer (Disease Ontology:DOID:1324); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); uveal melanoma (Disease Ontology:DOID:6039); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:17193); (R-MMU-110329); (R-MMU-110357)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10441743;10499592;12456671;21750661;34592200;37068447;9774669", "class_list": "", "function": "Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers., [RefSeq, PubMed]; G/T mismatch glycosylse. Acts to maintain levels of 5-methylcytosine in the genome by initiating repair of the results of deamination of 5-methylcytosine Erratum:[Nature 2000 Mar 30;404(6777):525], [RefSeq, PubMed]; Metastasis-associated lung adenocarcinoma transcript 1 induces methyl-CpG-binding domain protein 4 in mice with recurrent spontaneous abortion caused by anti-phospholipid antibody positivity., [RefSeq, PubMed]; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q792D2;Q8R3R3", "ec_number_list": "3.1.11.2;3.1.21.-;3.2.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009314 response to radiation;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z2D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CG85-1", "uniprot_id": "MAMC2_MOUSE", "mass": 77324.0, "length": 686, "protein_name": "MAM domain-containing protein 2", "gene_name": "Mamdc2", "organism": "Mouse", "refseq_name": "MAM domain-containing protein 2 precursor", "refseq_ac": "NP_777282", "gene_names_uniprotkb": "Mamdc2", "gene_names_refseq": "1200015L10Rik; Mamdc2; mamcan", "protein_names_uniprotkb": "MAM domain-containing protein 2; MAM domain-containing proteoglycan; Mamcan", "protein_names_refseq": "MAM domain-containing protein 2 precursor; MAM domain-containing protein 2; MAM domain-containing proteoglycan", "tax_id": 10090, "disease": "", "pathway": " (mmu:71738)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18757743;21750661", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BM24", "ec_number_list": "", "go_molecular_function": "GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0005614 interstitial matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CG85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMF3-1", "uniprot_id": "MAON_MOUSE", "mass": 67098.0, "length": 604, "protein_name": "NADP-dependent malic enzyme, mitochondrial", "gene_name": "Me3", "organism": "Mouse", "refseq_name": "NADP-dependent malic enzyme, mitochondrial", "refseq_ac": "NP_852072", "gene_names_uniprotkb": "Me3", "gene_names_refseq": "1700020C08Rik; B230207H15Rik; Me3", "protein_names_uniprotkb": "NADP-dependent malic enzyme, mitochondrial; 1.1.1.40; Malic enzyme 3; NADP-ME", "protein_names_refseq": "NADP-ME; NADP-dependent malic enzyme, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:109264); (R-MMU-70268)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;37507081;39927985;40684658", "class_list": "", "function": "Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+), and is able to reverse the reaction but only with significantly lower efficiency (By similarity). Can also catalyze the decarboxylation of oxaloacetate into pyruvate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499F4", "ec_number_list": "1.1.1.40;3.7.1.5;4.1.1.112;5.3.2.2;1.1.1.38", "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0046872 metal ion binding;GO:0051287 NAD binding;GO:0070401 NADP+ binding;GO:0004470 malic enzyme activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BMF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66JT1-1", "uniprot_id": "LRC8E_MOUSE", "mass": 90501.0, "length": 795, "protein_name": "Volume-regulated anion channel subunit LRRC8E", "gene_name": "Lrrc8e", "organism": "Mouse", "refseq_name": "volume-regulated anion channel subunit LRRC8E", "refseq_ac": "NP_082451", "gene_names_uniprotkb": "Lrrc8e", "gene_names_refseq": "1810049O03Rik; Lrrc8e", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8E; Leucine-rich repeat-containing protein 8E", "protein_names_refseq": "leucine-rich repeat-containing protein 8E; volume-regulated anion channel subunit LRRC8E", "tax_id": 10090, "disease": "", "pathway": " (mmu:72267); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;25428506;30084848;32277911;34428180;36522427", "class_list": "", "function": "Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:36522427). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:32277911). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:36522427). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QNV5", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0005225 volume-sensitive anion channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0006884 cell volume homeostasis;GO:0071470 cellular response to osmotic stress;GO:0015810 aspartate transmembrane transport;GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q66JT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIK2-1", "uniprot_id": "M17L2_MOUSE", "mass": 22514.0, "length": 200, "protein_name": "Mpv17-like protein 2", "gene_name": "Mpv17l2", "organism": "Mouse", "refseq_name": "mpv17-like protein 2", "refseq_ac": "NP_898993", "gene_names_uniprotkb": "Mpv17l2; Fksg24", "gene_names_refseq": "Fksg24; Mpv17l2", "protein_names_uniprotkb": "Mpv17-like protein 2", "protein_names_refseq": "mpv17-like protein 2", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 3 (Disease Ontology:DOID:0080121); mitochondrial DNA depletion syndrome 6 (Disease Ontology:DOID:0080125); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:234384)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THH2;Q80UR1", "ec_number_list": "", "go_molecular_function": "GO:0140978 mitochondrial large ribosomal subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0070131 positive regulation of mitochondrial translation;GO:0061668 mitochondrial ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VIK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78HU3-1", "uniprot_id": "MB12A_MOUSE", "mass": 28705.0, "length": 271, "protein_name": "Multivesicular body subunit 12A", "gene_name": "Mvb12a", "organism": "Mouse", "refseq_name": "multivesicular body subunit 12A", "refseq_ac": "NP_082893", "gene_names_uniprotkb": "Mvb12a; Fam125a", "gene_names_refseq": "1110012M11Rik; Fam125a; Mvb12a", "protein_names_uniprotkb": "Multivesicular body subunit 12A; ESCRT-I complex subunit MVB12A; Protein FAM125A", "protein_names_refseq": "ESCRT-I complex subunit MVB12A; family with sequence similarity 125, member A; multivesicular body subunit 12A", "tax_id": 10090, "disease": "", "pathway": " (mmu:73711); (R-MMU-917729)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17242355;21183079;21750661;30779550;31599954", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0008289 lipid binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0031982 vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0032801 receptor catabolic process;GO:0042058 regulation of epidermal growth factor receptor signaling pathway;GO:0046755 viral budding;GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q78HU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQQ8-1", "uniprot_id": "LSM7_MOUSE", "mass": 11636.0, "length": 103, "protein_name": "U6 snRNA-associated Sm-like protein LSm7", "gene_name": "Lsm7", "organism": "Mouse", "refseq_name": "U6 snRNA-associated Sm-like protein LSm7 isoform 4", "refseq_ac": "NP_079625", "gene_names_uniprotkb": "Lsm7", "gene_names_refseq": "0910001B06Rik; 1110033F18Rik; Lsm7", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm7", "protein_names_refseq": "LSM7 homolog, U6 small nuclear RNA associated; U6 snRNA-associated Sm-like protein LSm7 isoform 4; U6 snRNA-associated Sm-like protein LSm7", "tax_id": 10090, "disease": "", "pathway": " (mmu:66094); (R-MMU-430039); (R-MMU-72163)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0006402 mRNA catabolic process;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U1V8-1", "uniprot_id": "M3K9_MOUSE", "mass": 118805.0, "length": 1077, "protein_name": "Mitogen-activated protein kinase kinase kinase 9", "gene_name": "Map3k9", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 9 isoform 1", "refseq_ac": "NP_001167578", "gene_names_uniprotkb": "Map3k9", "gene_names_refseq": "E130314H24Rik; Map3k9; Mlk1; Prke1", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 9; 2.7.11.25", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 9 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:338372)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18036521;18414056;20971179;21750661;37537658", "class_list": "", "function": "MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis (By similarity)., [UniProtKB]; There is extensive functional redundancy between MLK1 and MLK2, and the other member of the family, MLK3, none of which are required for survival in mouse., [RefSeq, PubMed]; These results show that the expression of nucleosomal SRF-dependent genes, including the SMC gene, is activated by MKL1 via activation of SRF and recruitment of the FACT complex., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLZ4;Q8BIG8", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004706 JUN kinase kinase kinase activity;GO:0106310 protein serine kinase activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3U1V8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LE3-1", "uniprot_id": "LYSM3_MOUSE", "mass": 34258.0, "length": 305, "protein_name": "LysM and putative peptidoglycan-binding domain-containing protein 3", "gene_name": "Lysmd3", "organism": "Mouse", "refseq_name": "lysM and putative peptidoglycan-binding domain-containing protein 3", "refseq_ac": "NP_084533", "gene_names_uniprotkb": "Lysmd3", "gene_names_refseq": "1110030H10Rik; Lysmd3", "protein_names_uniprotkb": "LysM and putative peptidoglycan-binding domain-containing protein 3", "protein_names_refseq": "lysM and putative peptidoglycan-binding domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:80289)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;29496999", "class_list": "", "function": "Essential for Golgi structural integrity., [UniProtKB, UniProtKB]; Mouse LysMD3 is a type II integral membrane protein that co-localizes with GM130+ structures, consistent with localization to the Golgi apparatus. LysMD3-deficient mice were born at Mendelian ratios and had no obvious pathological abnormalities. They also exhibited no obvious immune response deficiencies in a number of models of infection and inflammation. LysMD3-deficient mice exhibited no signs of intestinal dysbiosis, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042834 peptidoglycan binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99LE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BL86-1", "uniprot_id": "MBLC2_MOUSE", "mass": 31205.0, "length": 279, "protein_name": "Acyl-coenzyme A thioesterase MBLAC2", "gene_name": "Mblac2", "organism": "Mouse", "refseq_name": "acyl-coenzyme A thioesterase MBLAC2", "refseq_ac": "NP_082648", "gene_names_uniprotkb": "Mblac2", "gene_names_refseq": "2900024O10Rik; Mblac2", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase MBLAC2; 3.1.2.2; 3.5.2.6; Acyl-CoA thioesterase MBLAC2; Beta-lactamase MBLAC2; Metallo-beta-lactamase domain-containing protein 2; Palmitoyl-coenzyme A thioesterase MBLAC2", "protein_names_refseq": "acyl-CoA thioesterase MBLAC2; acyl-coenzyme A thioesterase MBLAC2; beta-lactamase MBLAC2; metallo-beta-lactamase domain-containing protein 2; palmitoyl-coenzyme A thioesterase MBLAC2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72852)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X997", "ec_number_list": "3.1.2.2;3.1.2.-;3.1.2.22;3.4.13.19;3.5.2.6;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;3.1.1.4;3.1.1.5;2.3.1.16;2.3.1.9;3.1.-.-;3.1.2.14;2.3.1.65", "go_molecular_function": "GO:0046872 metal ion binding;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0008800 beta-lactamase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BL86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AE20-1", "uniprot_id": "LYZL5_MOUSE", "mass": 18005.0, "length": 160, "protein_name": "Sperm acrosome-associated protein 5", "gene_name": "Spaca5", "organism": "Mouse", "refseq_name": "sperm acrosome-associated protein 5 precursor", "refseq_ac": "NP_001078862", "gene_names_uniprotkb": "Spaca5; Gm718; Lyzl5", "gene_names_refseq": "Gm718; Lyze; Spaca5", "protein_names_uniprotkb": "Sperm acrosome-associated protein 5; 3.2.1.17; Lysozyme-like protein 5", "protein_names_refseq": "lysozyme e; lysozyme-like protein 5; novel C-type lysozyme/alpha-lactalbumin family domain containing protein; sperm acrosome-associated protein 5 precursor; sperm acrosome-associated protein 5", "tax_id": 10090, "disease": "viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (mmu:278203)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2AE20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8X0-1", "uniprot_id": "MANBL_MOUSE", "mass": 9340.0, "length": 85, "protein_name": "Protein MANBAL", "gene_name": "Manbal", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Manbal", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein MANBAL", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:69161)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDU6;Q91YV8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D8X0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3C3-1", "uniprot_id": "LZIC_MOUSE", "mass": 21537.0, "length": 190, "protein_name": "Protein LZIC", "gene_name": "Lzic", "organism": "Mouse", "refseq_name": "protein LZIC", "refseq_ac": "NP_081239", "gene_names_uniprotkb": "Lzic", "gene_names_refseq": "1810030J04Rik; Lzic", "protein_names_uniprotkb": "Protein LZIC; Leucine zipper and CTNNBIP1 domain-containing protein; Leucine zipper and ICAT homologous domain-containing protein", "protein_names_refseq": "leucine zipper and CTNNBIP1 domain-containing protein; leucine zipper and ICAT homologous domain-containing protein; protein LZIC", "tax_id": 10090, "disease": "osteosarcoma (Disease Ontology:DOID:3347)", "pathway": " (mmu:69151)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15932753;21750661;25428506;27802388;37507081", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8V3", "ec_number_list": "", "go_molecular_function": "GO:0008013 beta-catenin binding", "go_cellular_component": "", "go_biological_process": "GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K3C3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C8YR32-1", "uniprot_id": "LOXH1_MOUSE", "mass": 235757.0, "length": 2068, "protein_name": "Lipoxygenase homology domain-containing protein 1", "gene_name": "Loxhd1", "organism": "Mouse", "refseq_name": "lipoxygenase homology domain-containing protein 1 isoform 1", "refseq_ac": "NP_766422", "gene_names_uniprotkb": "Loxhd1", "gene_names_refseq": "1700096C21Rik; 4932417K07; Loxhd1; sba", "protein_names_uniprotkb": "Lipoxygenase homology domain-containing protein 1", "protein_names_refseq": "lipoxygenase homology domain-containing protein 1 isoform 1; lipoxygenase homology domain-containing protein 1", "tax_id": 10090, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); autosomal recessive nonsyndromic deafness 77 (Disease Ontology:DOID:0110525); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555)", "pathway": " (mmu:240411)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19732867;21750661;33707295;34418053", "class_list": "", "function": "Hearing loss in the ethylnitrosourea (ENU)-induced samba mouse line is caused by a mutation in Loxhd1., [RefSeq, PubMed]; Loxhd1 Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells., [RefSeq, PubMed]; Required for normal function of hair cells in the inner ear., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMY5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0032420 stereocilium", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "C8YR32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGR2-1", "uniprot_id": "LRC8D_MOUSE", "mass": 98113.0, "length": 859, "protein_name": "Volume-regulated anion channel subunit LRRC8D", "gene_name": "Lrrc8d", "organism": "Mouse", "refseq_name": "volume-regulated anion channel subunit LRRC8D", "refseq_ac": "NP_001116240", "gene_names_uniprotkb": "Lrrc8d; Lrrc5", "gene_names_refseq": "2810473G09Rik; 4930525N13Rik; A930019F03; Lrrc5; Lrrc8d", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8D; Leucine-rich repeat-containing protein 5; Leucine-rich repeat-containing protein 8D", "protein_names_refseq": "leucine rich repeat containing 5; leucine-rich repeat-containing protein 5; leucine-rich repeat-containing protein 8D; volume-regulated anion channel subunit LRRC8D", "tax_id": 10090, "disease": "", "pathway": " (mmu:231549); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "20484733;21750661;22872234;24782309;25428506;27802388;29773801;30084848;34428180;36522427", "class_list": "", "function": "Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29773801, PubMed:36522427). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29773801). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:36522427)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVA9;Q8CI13", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0005225 volume-sensitive anion channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0001678 intracellular glucose homeostasis;GO:0015734 taurine transmembrane transport;GO:0071470 cellular response to osmotic stress;GO:0034214 protein hexamerization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BGR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UVD5-1", "uniprot_id": "LGR6_MOUSE", "mass": 104267.0, "length": 967, "protein_name": "Leucine-rich repeat-containing G protein-coupled receptor 6", "gene_name": "Lgr6", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing G-protein coupled receptor 6 isoform a precursor", "refseq_ac": "NP_001028581", "gene_names_uniprotkb": "Lgr6", "gene_names_refseq": "A530037C04Rik; D830026M09; Lgr6", "protein_names_uniprotkb": "Leucine-rich repeat-containing G protein-coupled receptor 6", "protein_names_refseq": "leucine-rich repeat-containing G-protein coupled receptor 6 isoform a precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:329252)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12679517;20223988;21750661;22002312;29769720;31219806;35820727", "class_list": "", "function": "Lgr5 has been identified as a marker of Wnt-regulated adult stem cell populations in the hair-follicle, intestine and stomach. A closely-related protein, Lgr6 marks adult stem cells responsible for fueling the renewal of the sebaceous gland and skin.[Review] Review article, [RefSeq, PubMed]; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal (By similarity)., [UniProtKB]; Study concludes that Lgr6 marks the most primitive epidermal stem cell, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RUL8;Q80UB8;Q8R301", "ec_number_list": "", "go_molecular_function": "GO:0016500 protein-hormone receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031982 vesicle", "go_biological_process": "GO:0008283 cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0016055 Wnt signaling pathway;GO:0042246 tissue regeneration;GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UVD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA03-1", "uniprot_id": "LYRM7_MOUSE", "mass": 12047.0, "length": 104, "protein_name": "Complex III assembly factor LYRM7", "gene_name": "Lyrm7", "organism": "Mouse", "refseq_name": "complex III assembly factor LYRM7 isoform 1", "refseq_ac": "NP_083603", "gene_names_uniprotkb": "Lyrm7; MZM1L", "gene_names_refseq": "1700024C24Rik; 9330147L21Rik; Lyrm7", "protein_names_uniprotkb": "Complex III assembly factor LYRM7; LYR motif-containing protein 7", "protein_names_refseq": "LYR motif-containing protein 7; complex III assembly factor LYRM7 isoform 1; complex III assembly factor LYRM7", "tax_id": 10090, "disease": "mitochondrial complex III deficiency nuclear type 8 (Disease Ontology:DOID:0080117); mitochondrial complex III deficiency (Disease Ontology:DOID:0111139); lactic acidosis (Disease Ontology:DOID:3650)", "pathway": " (mmu:75530); (R-MMU-9865881)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZDF8", "ec_number_list": "", "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DA03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09056-1", "uniprot_id": "LIF_MOUSE", "mass": 22287.0, "length": 203, "protein_name": "Leukemia inhibitory factor", "gene_name": "Lif", "organism": "Mouse", "refseq_name": "leukemia inhibitory factor isoform b", "refseq_ac": "NP_001034626", "gene_names_uniprotkb": "Lif", "gene_names_refseq": "Lif", "protein_names_uniprotkb": "Leukemia inhibitory factor; D factor; Differentiation-stimulating factor; LIF", "protein_names_refseq": "d factor; differentiation-stimulating factor; leukemia inhibitory factor isoform b; myeloid leukaemia inhibitory factor", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:16878); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10438970;1522892;15328362;16452727;1692837;21750661;2475312;26775702;3127201;3143916;3147726;3186448;39084258;39112698;39341481;8020098;8422244;8921810;9254611;9545305;9593715", "class_list": "", "function": "Augmentative effects of leukemia inhibitory factor reveal a critical role for TYK2 signaling in vascular calcification., [RefSeq, PubMed]; Functions as a cytokine that binds to the LIF receptor complex (By similarity). The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (By similarity). Functionally, regulates cell self-renewal, differentiation and survival of embryonic stem cells (EScs) and is crucial for embryonic implantation (PubMed:1522892, PubMed:16452727, PubMed:26775702, PubMed:3127201, PubMed:3143916). Mechanistically, ligand binding to LIFR, induces heterodimerization with IL6ST/gp130 activating JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains (PubMed:8921810). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (PubMed:8921810). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducers and activators of transcription (STAT3 and to lesser extent STAT1) (PubMed:8921810). In parallel to the activation of the STAT3-pathway, the binding of LIF to the LIF receptor complex leads to the activation of the mitogen-activated protein kinase (MAPK) and the phosphatidylinositol 3-kinase (PI(3)K) pathways (PubMed:15328362, PubMed:9545305). Tyrosine phosphorylation of the p85 subunit of PI(3)K by JAK1 leads to activation of the serine/ threonine kinase AKT (protein kinase B) (PubMed:9545305). PI(3)K-dependent signaling is required for efficient self-renewal of murine ES cells, and regulation of ERK activity is functionally important in this response (PubMed:15328362). Moreover, induces tyrosine phosphorylation of PTPN11, that associates with IL6ST/gp130-LIFR, which in turn recruits the p85 regulatory subunit of PI(3)K protein kinase, promoting PI3K-AKT activation, and (in many systems) GRB2-RAS-MAPK signaling (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; ILC2-derived LIF licences progress from tissue to systemic immunity., [RefSeq, PubMed]; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes., [UniProtKB, UniProtKB]; Lif-deficiency promote systemic Iron metabolism disorders and increases the susceptibility of osteoblasts to ferroptosis., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005146 leukemia inhibitory factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P09056-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41149-1", "uniprot_id": "MC5R_MOUSE", "mass": 36953.0, "length": 325, "protein_name": "Melanocortin receptor 5", "gene_name": "Mc5r", "organism": "Mouse", "refseq_name": "melanocortin receptor 5", "refseq_ac": "NP_038624", "gene_names_uniprotkb": "Mc5r", "gene_names_refseq": "Mc5r", "protein_names_uniprotkb": "Melanocortin receptor 5; MC5-R", "protein_names_refseq": "MC5-R; melanocortin receptor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:17203); (R-MMU-375276); (R-MMU-418555)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "21750661;31287586;33617397;35926007;36920787;7739752;8161509;8185570;9413988", "class_list": "", "function": "G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:35926007, PubMed:7739752, PubMed:8185570, PubMed:9413988). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway (PubMed:7739752, PubMed:8185570, PubMed:9413988). Also activates ERK1/2 via a PI3K-dependent signaling mechanism (PubMed:35926007). Order of potency of natural melanocortins in receptor activation is alpha-MSH > beta-MSH > ACTH > gamma-MSH (PubMed:7739752, PubMed:8185570). Plays a key role in immune response, and is essential for temperature regulation and exocrine gland function (PubMed:35926007, PubMed:9413988)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Melanocortin 5 Receptor Expression and Recovery of Ocular Immune Privilege after Uveitis., [RefSeq, PubMed]; Melanocortin/MC5R axis regulates the proliferation of hematopoietic stem cells in mice after ionizing radiation injury., [RefSeq, PubMed]; This report demonstrates that obesity exacerbates autoimmune uveitis and inhibits the promotion of post-experimental autoimmune uveitis regulatory immunity through the melanocortin 5 receptor., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0042562 hormone binding;GO:0004977 melanocortin receptor activity;GO:0004978 corticotropin receptor activity;GO:0004980 melanocyte-stimulating hormone receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0060259 regulation of feeding behavior;GO:0050777 negative regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P41149-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99M02-1", "uniprot_id": "MARH2_MOUSE", "mass": 27186.0, "length": 246, "protein_name": "E3 ubiquitin-protein ligase MARCHF2", "gene_name": "Marchf2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MARCHF2 isoform 2", "refseq_ac": "NP_001239409", "gene_names_uniprotkb": "Marchf2; March2; Rnf172", "gene_names_refseq": "9530046H09Rik; MARCH-II; March2; Marchf2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF2; 2.3.2.27; MARCH-II; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCHF2", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH2; E3 ubiquitin-protein ligase MARCHF2 isoform 2; E3 ubiquitin-protein ligase MARCHF2; RING finger protein 172; RING-type E3 ubiquitin transferase MARCH2; RING-type E3 ubiquitin transferase MARCHF2; membrane-associated RING finger protein 2; membrane-associated RING-CH protein II; membrane-associated ring finger (C3HC4) 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:224703)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;32935379;33945654;34428180;35982175", "class_list": "", "function": "E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Ubiquitinates and therefore mediates the degradation of DLG1 (By similarity). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (By similarity). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (PubMed:32935379). May be involved in endosomal trafficking through interaction with STX6., [UniProtKB, UniProtKB, PubMed]; Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2., [RefSeq, PubMed]; Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9., [RefSeq, PubMed]; The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4Q5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0044790 suppression of viral release by host;GO:1905167 positive regulation of lysosomal protein catabolic process;GO:0006897 endocytosis;GO:0016567 protein ubiquitination;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99M02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09108-1", "uniprot_id": "LSHB_MOUSE", "mass": 15028.0, "length": 141, "protein_name": "Lutropin subunit beta", "gene_name": "Lhb", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lhb", "gene_names_refseq": "", "protein_names_uniprotkb": "Lutropin subunit beta; LH-B; LSH-B; LSH-beta; Luteinizing hormone subunit beta; Lutropin beta chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 23 with or without anosmia (Disease Ontology:DOID:0090091); severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (mmu:16866); (R-MMU-193048); (R-MMU-193993); (R-MMU-209822); (R-MMU-375281); (R-MMU-418555); (R-MMU-8866910); (R-MMU-975578)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "21750661;23371388;8543188", "class_list": "", "function": "Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q60844", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0061696 pituitary gonadotropin complex;GO:0005576 extracellular region", "go_biological_process": "GO:0001541 ovarian follicle development;GO:0042700 luteinizing hormone signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O09108-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89017-1", "uniprot_id": "LGMN_MOUSE", "mass": 49373.0, "length": 435, "protein_name": "Legumain", "gene_name": "Lgmn", "organism": "Mouse", "refseq_name": "legumain preproprotein", "refseq_ac": "NP_035305", "gene_names_uniprotkb": "Lgmn; Prsc1", "gene_names_refseq": "AEP; Lgmn; Prsc1", "protein_names_uniprotkb": "Legumain; 3.4.22.34; Protease, cysteine 1", "protein_names_refseq": "asparaginyl endopeptidase; legumain preproprotein; preprolegumain; protease, cysteine, 1", "tax_id": 10090, "disease": "lymphatic system disease (Disease Ontology:DOID:75)", "pathway": " (mmu:19141); (R-MMU-1679131); (R-MMU-2132295)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;11180120;17350006;21292981;24407422;26495903;26740625;30084848;30899004;31219806;31616917;32152506;33300544;34428180;37347855;38815795;40885482;40997131;9742219;9821970;9891971", "class_list": "", "function": "Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:24407422, PubMed:9742219, PubMed:9891971). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:24407422, PubMed:9742219, PubMed:9891971). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (PubMed:37347855). Required for normal lysosomal protein degradation in renal proximal tubules (PubMed:17350006, PubMed:21292981). Required for normal degradation of internalized EGFR (PubMed:21292981). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (PubMed:21292981)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Legumain-deficient macrophages regulate inflammation and lipid metabolism in adipose tissues to protect against diet-induced obesity., [RefSeq, PubMed]; This gene encodes a member of the cysteine peptidase family C13 that plays an important role in the endosome/lysosomal degradation system. The encoded inactive preproprotein undergoes autocatalytic removal of the C-terminal inhibitory propeptide to generate the active endopeptidase that cleaves protein substrates on the C-terminal side of asparagine residues. Mice lacking the encoded protein exhibit defects in the lysosomal processing of proteins resulting in their accumulation in the lysosomes, and develop symptoms resembling hemophagocytic lymphohistiocytosis. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.22.27;3.4.22.34;3.4.22.15;3.4.22.1;3.4.22.38", "go_molecular_function": "GO:0008233 peptidase activity;GO:0061133 endopeptidase activator activity;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0045177 apical part of cell;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0006508 proteolysis;GO:0007613 memory;GO:0008284 positive regulation of cell population proliferation;GO:0008306 associative learning", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "O89017-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01723-1", "uniprot_id": "LV1A_MOUSE", "mass": 12222.0, "length": 117, "protein_name": "Ig lambda-1 chain V region", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig lambda-1 chain V region", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "103630", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01723-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01726-1", "uniprot_id": "LV1D_MOUSE", "mass": 13465.0, "length": 129, "protein_name": "Ig lambda-1 chain V region H2020", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig lambda-1 chain V region H2020", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "103630", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01726-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08923-1", "uniprot_id": "LTK_MOUSE", "mass": 94471.0, "length": 888, "protein_name": "Leukocyte tyrosine kinase receptor", "gene_name": "Ltk", "organism": "Mouse", "refseq_name": "leukocyte tyrosine kinase receptor isoform D precursor", "refseq_ac": "NP_976220", "gene_names_uniprotkb": "Ltk", "gene_names_refseq": "Ltk", "protein_names_uniprotkb": "Leukocyte tyrosine kinase receptor; 2.7.10.1", "protein_names_refseq": "leukocyte receptor tyrosine kinase; leukocyte tyrosine kinase receptor isoform D precursor", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:17005); (R-MMU-9842663)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14695357;1662793;21750661;22079349;2357970;2836739;37291945;8380920;8995435", "class_list": "", "function": "LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity., [RefSeq, PubMed]; Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (By similarity). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity). The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons. [provided by RefSeq, Jul 2008]., [RefSeq]; Translation initiates from a non-AUG codon (CUG) in some Ltk transcript variants., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ22", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.23", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0030298 receptor signaling protein tyrosine kinase activator activity;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008283 cell population proliferation;GO:0010976 positive regulation of neuron projection development;GO:0038083 peptidyl-tyrosine autophosphorylation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P08923-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30730-1", "uniprot_id": "LSHR_MOUSE", "mass": 78215.0, "length": 700, "protein_name": "Lutropin-choriogonadotropic hormone receptor", "gene_name": "Lhcgr", "organism": "Mouse", "refseq_name": "lutropin-choriogonadotropic hormone receptor isoform 1 precursor", "refseq_ac": "NP_038610", "gene_names_uniprotkb": "Lhcgr; Lhr", "gene_names_refseq": "Gpcr19-rs1; LH-R; LH/CG-R; LSH-R; Lhcgr; Lhr", "protein_names_uniprotkb": "Lutropin-choriogonadotropic hormone receptor; LH/CG-R; LSH-R; Luteinizing hormone receptor", "protein_names_refseq": "lutropin-choriogonadotropic hormone receptor isoform 1 precursor; lutropin-choriogonadotropic hormone receptor", "tax_id": 10090, "disease": "familial male-limited precocious puberty (Disease Ontology:DOID:0111545); Leydig cell hypoplasia (Disease Ontology:DOID:0112259); breast cancer (Disease Ontology:DOID:1612); gonadal disease (Disease Ontology:DOID:2277); Leydig cell tumor (Disease Ontology:DOID:2696); granulosa cell tumor (Disease Ontology:DOID:2999); serous cystadenocarcinoma (Disease Ontology:DOID:3114); mucinous cystadenocarcinoma (Disease Ontology:DOID:3603)", "pathway": " (mmu:16867); (R-MMU-375281); (R-MMU-418555)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1311310;1459341;18299400;21750661;34428180;39031603", "class_list": "", "function": "Comprehensive Analysis of Damage Associated SNPs of Luteinizing Hormone and Its Receptor: A Computational Approach., [RefSeq, PubMed]; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004964 luteinizing hormone receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0034451 centriolar satellite", "go_biological_process": "GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0046544 development of secondary male sexual characteristics;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P30730-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35459-1", "uniprot_id": "LY6D_MOUSE", "mass": 13396.0, "length": 127, "protein_name": "Lymphocyte antigen 6D", "gene_name": "Ly6d", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6D precursor", "refseq_ac": "NP_034872", "gene_names_uniprotkb": "Ly6d; Ly61; Thb", "gene_names_refseq": "Ly-61; Ly61; Ly6d; Thb", "protein_names_uniprotkb": "Lymphocyte antigen 6D; Ly-6D; ThB; Thymocyte B-cell antigen", "protein_names_refseq": "ly-6D; lymphocyte antigen 6 complex, locus D; lymphocyte antigen 6D precursor; lymphocyte antigen 6D; thymocyte B-cell antigen", "tax_id": 10090, "disease": "", "pathway": " (mmu:17068); (R-MMU-163125)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1401899;19833765;34428180;37060563;7642235", "class_list": "", "function": "Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells., [RefSeq, PubMed]; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098552 side of membrane", "go_biological_process": "GO:0035634 response to stilbenoid;GO:0030098 lymphocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P35459-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35460-1", "uniprot_id": "LY6F_MOUSE", "mass": 14599.0, "length": 134, "protein_name": "Lymphocyte antigen 6F", "gene_name": "Ly6f", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6F precursor", "refseq_ac": "NP_032556", "gene_names_uniprotkb": "Ly6f", "gene_names_refseq": "Ly6f", "protein_names_uniprotkb": "Lymphocyte antigen 6F; Ly-6F.1; Ly-6F", "protein_names_refseq": "ly-6F.1; ly-6F; lymphocyte antigen 6 complex, locus F; lymphocyte antigen 6F precursor; lymphocyte antigen 6F", "tax_id": 10090, "disease": "", "pathway": " (mmu:17071)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8515066", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35460-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39654-1", "uniprot_id": "LOX15_MOUSE", "mass": 75445.0, "length": 663, "protein_name": "Polyunsaturated fatty acid lipoxygenase ALOX15", "gene_name": "Alox15", "organism": "Mouse", "refseq_name": "polyunsaturated fatty acid lipoxygenase ALOX15", "refseq_ac": "NP_033790", "gene_names_uniprotkb": "Alox15; Alox12l", "gene_names_refseq": "12-LO; 12/15-LO; 15-LOX; Alox12l; Alox15; L-12LO", "protein_names_uniprotkb": "Polyunsaturated fatty acid lipoxygenase ALOX15; 1.13.11.-; 1.13.11.12; 1.13.11.31; 1.13.11.33; 12-LOX; 12/15-LO; 12/15-lipoxygenase; 15-LOX; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate 15-lipoxygenase; Arachidonate omega-6 lipoxygenase; Hepoxilin A3 synthase Alox15; L-12LO; Linoleate 13S-lipoxygenase", "protein_names_refseq": "12-LOX; 12/15-lipoxygenase; arachidonate 12-lipoxygenase, leukocyte-type; arachidonate omega-6 lipoxygenase; hepoxilin A3 synthase Alox15; linoleate 13S-lipoxygenase; polyunsaturated fatty acid lipoxygenase ALOX15", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); brain ischemia (Disease Ontology:DOID:2316); glomerulonephritis (Disease Ontology:DOID:2921); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:11687); (R-MMU-2142691); (R-MMU-2142712); (R-MMU-2142770); (R-MMU-9018677); (R-MMU-9018681); (R-MMU-9018896); (R-MMU-9023661); (R-MMU-9025106); (R-MMU-9026286)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "10432118;11278875;14716014;15708862;22215650;22503541;34428180;7811740;8188678;8798642", "class_list": "", "function": "Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:8188678). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:8188678). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (By similarity). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response (PubMed:22503541). In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties (PubMed:15708862). Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells (PubMed:11278875). It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function (PubMed:10432118). It may also exert a negative effect on skeletal development by regulating bone mass through this pathway (PubMed:14716014). As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (PubMed:22215650). Finally, it is also involved in the cellular response to IL13/interleukin-13 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJY9;Q5F2E3;Q6PHB2", "ec_number_list": "1.13.11.-;1.13.11.58;1.13.11.31;1.13.11.33;1.13.11.12;1.13.11.34", "go_molecular_function": "GO:0005506 iron ion binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0016165 linoleate 13S-lipoxygenase activity;GO:0047977 hepoxilin-epoxide hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0034440 lipid oxidation;GO:2001301 lipoxin biosynthetic process;GO:0006629 lipid metabolic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0043651 linoleic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P39654-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49718-1", "uniprot_id": "MCM5_MOUSE", "mass": 82407.0, "length": 734, "protein_name": "DNA replication licensing factor MCM5", "gene_name": "Mcm5", "organism": "Mouse", "refseq_name": "DNA replication licensing factor MCM5", "refseq_ac": "NP_001289469", "gene_names_uniprotkb": "Mcm5; Cdc46; Mcmd5", "gene_names_refseq": "Cdc46; Mcm5; Mcmd5; P1-CDC46", "protein_names_uniprotkb": "DNA replication licensing factor MCM5; 3.6.4.12; CDC46 homolog; P1-CDC46", "protein_names_refseq": "CDC46 homolog; DNA replication licensing factor MCM5; mini chromosome maintenance deficient 5; minichromosome maintenance deficient 5, cell division cycle 46", "tax_id": 10090, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); Meier-Gorlin syndrome 8 (Disease Ontology:DOID:0080255); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:17218); (R-MMU-176187); (R-MMU-68867); (R-MMU-68949); (R-MMU-68962); (R-MMU-69052)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "22872234;26740625;34428180;34887587;39627609;7610039", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the oligameric minichromosome maintenance protein complex. During DNA replication, the complex loads onto chromatin in early G1 and is converted into an active replicative helicase during S phase. It functions to limit DNA synthesis to once per cell cycle. During embryogenesis, the encoded protein is negatively regulated through expression of paired box protein Pax 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52KC3", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;2.7.7.102;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;2.7.7.7;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;2.7.11.22;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.49;2.7.11.1;2.7.4.3;3.1.11.-", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication;GO:0006279 premeiotic DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P49718-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50538-1", "uniprot_id": "MAD1_MOUSE", "mass": 25562.0, "length": 227, "protein_name": "Max dimerization protein 1", "gene_name": "Mxd1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mxd1; Mad1; Mad", "gene_names_refseq": "", "protein_names_uniprotkb": "Max dimerization protein 1; Max dimerizer 1; Protein MAD", "protein_names_refseq": "", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "10597267;21750661;7667316;7896882;8521822;9519870", "class_list": "", "function": "Component of a transcriptional repressor complex together with MAX (By similarity). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (By similarity). Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (By similarity). Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60798;Q61825", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P50538-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56450-1", "uniprot_id": "MC4R_MOUSE", "mass": 36959.0, "length": 332, "protein_name": "Melanocortin receptor 4", "gene_name": "Mc4r", "organism": "Mouse", "refseq_name": "melanocortin receptor 4", "refseq_ac": "NP_058673", "gene_names_uniprotkb": "Mc4r", "gene_names_refseq": "Mc4-r; Mc4r; Pkcp", "protein_names_uniprotkb": "Melanocortin receptor 4; MC4-R", "protein_names_refseq": "melanocortin receptor 4", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); sciatic neuropathy (Disease Ontology:DOID:11446); morbid obesity (Disease Ontology:DOID:11981); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); morphine dependence (Disease Ontology:DOID:2560); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17202); (R-MMU-375276); (R-MMU-418555)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14531729;23869016;25600267;39951488;9019399", "class_list": "", "function": "G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (By similarity). Functions as a central component of the leptin-melanocortin pathway, which is essential for maintaining energy homeostasis (PubMed:23869016). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which promotes anorexogenic signaling in the hypothalamus and contributes to a negative energy balance (PubMed:23869016). Regulates food intake: activation by agonists suppresses appetite, whereas the antagonist Agouti-related protein/AGRP precludes agonist-induced signaling, thereby stimulating appetite (PubMed:9019399). Modulates the firing activity of neurons in paraventricular nucleus (PVN) of the hypothalamus via alpha-MSH and AGRP regulation of inwardly rectifying potassium channel KCNJ13 closure, independently of G(s) signaling (PubMed:25600267). In the PVN, also interacts with opsin 3/OPN3, which couples to G(i/o) proteins to inhibit MC4R-mediated cAMP signaling, thereby promoting food intake (PubMed:39951488). In intestinal epithelial cells, contributes to inhibition of hepatic glucose production via nesfatin-1/NUCB2, leading to increased cAMP levels and glucagon-like peptide 1 (GLP-1) secretion (By similarity). Interaction with MGRN1 displaces the G(s) protein, further decreasing MC4R signaling activity. Also activated by gamma-MSH, though with low potency (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased cholesterol levels and insulin resistance. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q49NR4;Q9EQM7", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0042562 hormone binding;GO:0017046 peptide hormone binding;GO:0004977 melanocortin receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098804 non-motile cilium membrane", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:2000252 negative regulation of feeding behavior;GO:1903998 regulation of eating behavior;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P56450-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61375-1", "uniprot_id": "LHX5_MOUSE", "mass": 44388.0, "length": 402, "protein_name": "LIM/homeobox protein Lhx5", "gene_name": "Lhx5", "organism": "Mouse", "refseq_name": "LIM/homeobox protein Lhx5", "refseq_ac": "NP_032525", "gene_names_uniprotkb": "Lhx5", "gene_names_refseq": "Lhx5; Lim2", "protein_names_uniprotkb": "LIM/homeobox protein Lhx5; LIM homeobox protein 5", "protein_names_refseq": "LIM homeo box protein 5; LIM/homeobox protein Lhx5", "tax_id": 10090, "disease": "", "pathway": " (mmu:16873)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8812449", "class_list": "", "function": "Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P50459", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007267 cell-cell signaling;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61375-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62311-1", "uniprot_id": "LSM3_MOUSE", "mass": 11845.0, "length": 102, "protein_name": "U6 snRNA-associated Sm-like protein LSm3", "gene_name": "Lsm3", "organism": "Mouse", "refseq_name": "U6 snRNA-associated Sm-like protein LSm3", "refseq_ac": "NP_080585", "gene_names_uniprotkb": "Lsm3", "gene_names_refseq": "1010001J12Rik; 2610005D18Rik; 6030401D18Rik; Lsm3; SMX4; USS2", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm3", "protein_names_refseq": "LSM3 homolog, U6 small nuclear RNA associated; U6 snRNA-associated Sm-like protein LSm3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67678); (R-MMU-430039); (R-MMU-72163)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "25428506;31219806;34428180", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Y4Z1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0030629 U6 snRNA 3'-end binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0000932 P-body;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0033962 P-body assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62311-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TRR0-1", "uniprot_id": "MAP9_MOUSE", "mass": 73511.0, "length": 646, "protein_name": "Microtubule-associated protein 9", "gene_name": "Map9", "organism": "Mouse", "refseq_name": "microtubule-associated protein 9", "refseq_ac": "NP_001074699", "gene_names_uniprotkb": "Map9; Asap; Mtap9", "gene_names_refseq": "5033421J10Rik; 5330427D05Rik; ASAP; Map9; Mtap9", "protein_names_uniprotkb": "Microtubule-associated protein 9; Aster-associated protein", "protein_names_refseq": "aster-associated protein; microtubule-associated protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:213582)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31662330", "class_list": "", "function": "Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules (By similarity)., [UniProtKB]; MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUD1;Q3UX85;Q3UXE7;Q5M8N8;Q6P8K1;Q8BMM4;Q8BYP7", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000235 astral microtubule;GO:0005737 cytoplasm;GO:0030424 axon;GO:0051233 spindle midzone;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0046602 regulation of mitotic centrosome separation;GO:0090307 mitotic spindle assembly;GO:0000281 mitotic cytokinesis;GO:0060236 regulation of mitotic spindle organization;GO:1902412 regulation of mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TRR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TYX2-1", "uniprot_id": "LRN4L_MOUSE", "mass": 25931.0, "length": 239, "protein_name": "LRRN4 C-terminal-like protein", "gene_name": "Lrrn4cl", "organism": "Mouse", "refseq_name": "LRRN4 C-terminal-like protein precursor", "refseq_ac": "NP_001013037", "gene_names_uniprotkb": "Lrrn4cl", "gene_names_refseq": "1110067I12Rik; Lrrn4cl", "protein_names_uniprotkb": "LRRN4 C-terminal-like protein", "protein_names_refseq": "LRRN4 C-terminal-like protein precursor; LRRN4 C-terminal-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68852)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;33758365", "class_list": "", "function": "CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3TYX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHC2-1", "uniprot_id": "LRRK1_MOUSE", "mass": 225470.0, "length": 2014, "protein_name": "Leucine-rich repeat serine/threonine-protein kinase 1", "gene_name": "Lrrk1", "organism": "Mouse", "refseq_name": "leucine-rich repeat serine/threonine-protein kinase 1", "refseq_ac": "NP_666303", "gene_names_uniprotkb": "Lrrk1; Kiaa1790", "gene_names_refseq": "C230002E15Rik; D130026O16Rik; Lrrk1; mKIAA1790", "protein_names_uniprotkb": "Leucine-rich repeat serine/threonine-protein kinase 1; 2.7.11.1", "protein_names_refseq": "leucine-rich repeat serine/threonine-protein kinase 1", "tax_id": 10090, "disease": "Parkinson's disease 8 (Disease Ontology:DOID:0060371); late onset Parkinson's disease (Disease Ontology:DOID:0060892); osteosclerotic metaphyseal dysplasia (Disease Ontology:DOID:0081111); osteopetrosis (Disease Ontology:DOID:13533); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:233328); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;23526378;25428506;27055475;31219806;33459343;34428180;35820727;37828378", "class_list": "", "function": "Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms. Erratum:[Biochem J. 2025 Apr 10;482(7):357-358. doi: 10.1042/BCJ20200937_COR. PMID: 40219994], [RefSeq, PubMed]; Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking (By similarity). Phosphorylates RAB7A; this activity is dependent on protein kinase C (PKC) activation (By similarity). Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts (PubMed:23526378, PubMed:27055475)., [UniProtKB, UniProtKB, PubMed, PubMed]; Skeletal phenotypes in Lrrk1 and Lrrk2 knockout (KO) mice, were investigated., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U476;Q66JQ4;Q6GQR9;Q6NZF5;Q6ZPI4;Q8BKP3;Q8BU93;Q8BUY0;Q8BVV2;Q8R085", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.3.2.26;2.3.2.36;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation;GO:0045453 bone resorption;GO:0036035 osteoclast development;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UHC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UJB3-1", "uniprot_id": "LR14B_MOUSE", "mass": 56543.0, "length": 510, "protein_name": "Leucine-rich repeat-containing protein 14B", "gene_name": "Lrrc14b", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 14B", "refseq_ac": "NP_001028214", "gene_names_uniprotkb": "Lrrc14b", "gene_names_refseq": "Lrrc14b", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 14B", "protein_names_refseq": "leucine-rich repeat-containing protein 14B", "tax_id": 10090, "disease": "", "pathway": " (mmu:432779)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31599954", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1Y3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UJB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UM18-1", "uniprot_id": "LSG1_MOUSE", "mass": 73157.0, "length": 644, "protein_name": "Large subunit GTPase 1 homolog", "gene_name": "Lsg1", "organism": "Mouse", "refseq_name": "large subunit GTPase 1 homolog isoform 1", "refseq_ac": "NP_835170", "gene_names_uniprotkb": "Lsg1; D16Bwg1547e", "gene_names_refseq": "5830465I20; D16Bwg1547e; Lsg1", "protein_names_uniprotkb": "Large subunit GTPase 1 homolog; 3.6.5.-", "protein_names_refseq": "large subunit GTPase 1 homolog isoform 1; large subunit GTPase 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:224092)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22872234;31219806;34203471;34428180;36210013;37828378", "class_list": "", "function": "Functions as a GTPase. May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q68ED9;Q80V36", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0015030 Cajal body", "go_biological_process": "GO:0015031 protein transport;GO:0000054 ribosomal subunit export from nucleus;GO:0051168 nuclear export", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UM18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UYG8-1", "uniprot_id": "MACD2_MOUSE", "mass": 52145.0, "length": 475, "protein_name": "ADP-ribose glycohydrolase MACROD2", "gene_name": "Macrod2", "organism": "Mouse", "refseq_name": "ADP-ribose glycohydrolase MACROD2 isoform 1", "refseq_ac": "NP_001013824", "gene_names_uniprotkb": "Macrod2", "gene_names_refseq": "1110033L15Rik; 2610107G07Rik; 2900006F19Rik; Macrod2", "protein_names_uniprotkb": "ADP-ribose glycohydrolase MACROD2; 3.2.2.-; 3.5.1.-; MACRO domain-containing protein 2; O-acetyl-ADP-ribose deacetylase MACROD2; [Protein ADP-ribosylaspartate] hydrolase MACROD2; [Protein ADP-ribosylglutamate] hydrolase MACROD2", "protein_names_refseq": "ADP-ribose glycohydrolase MACROD2 isoform 1; ADP-ribose glycohydrolase MACROD2; MACRO domain containing 2; MACRO domain-containing protein 2; O-acetyl-ADP-ribose deacetylase MACROD2; [Protein ADP-ribosylaspartate] hydrolase MACROD2; [Protein ADP-ribosylglutamate] hydrolase MACROD2; [Protein ADP-ribosylglutamate] hydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:72899)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17586838;21750661;30227424;33578760", "class_list": "", "function": "Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice. Publication Status: Online-Only, [RefSeq, PubMed]; MacroD2 is expressed and may have a physiological role in the central nervous system during brain development, [RefSeq, PubMed]; Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.2.19;3.5.1.-;3.2.2.-;3.2.1.143;3.1.1.106", "go_molecular_function": "GO:0019213 deacetylase activity;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0061463 O-acetyl-ADP-ribose deacetylase activity;GO:0140293 ADP-ribosylglutamate hydrolase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0009617 response to bacterium;GO:0006974 DNA damage response;GO:0007420 brain development;GO:0051725 protein de-ADP-ribosylation;GO:0042278 purine nucleoside metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UYG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WQ8-1", "uniprot_id": "M18BP_MOUSE", "mass": 113956.0, "length": 998, "protein_name": "Mis18-binding protein 1", "gene_name": "Mis18bp1", "organism": "Mouse", "refseq_name": "mis18-binding protein 1 isoform 1", "refseq_ac": "NP_766166", "gene_names_uniprotkb": "Mis18bp1; Kiaa1903; Knl2; M18bp1", "gene_names_refseq": "6720403H11; Knl2; Mis18bp1; mKIAA1903", "protein_names_uniprotkb": "Mis18-binding protein 1; Kinetochore-associated protein KNL-2 homolog", "protein_names_refseq": "kinetochore-associated protein KNL-2 homolog; mis18-binding protein 1 isoform 1; mis18-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:217653); (R-MMU-606279); (R-MMU-69273)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21228480;21750661;22540025;31219806;34418053;34428180", "class_list": "", "function": "CENP-C works as an important factor for centromeric M18BP1 recruitment, [RefSeq, PubMed]; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q571G6;Q8BPR7;Q8CBB5;Q8CG92", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0000775 chromosome, centromeric region;GO:0098654 CENP-A recruiting complex", "go_biological_process": "GO:0051301 cell division;GO:0034080 CENP-A containing chromatin assembly;GO:0140462 pericentric heterochromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80WQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XU8-1", "uniprot_id": "LRFN4_MOUSE", "mass": 67252.0, "length": 636, "protein_name": "Leucine-rich repeat and fibronectin type-III domain-containing protein 4", "gene_name": "Lrfn4", "organism": "Mouse", "refseq_name": "leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor", "refseq_ac": "NP_700437", "gene_names_uniprotkb": "Lrfn4; Salm3", "gene_names_refseq": "Lrfn4; Salm3", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type-III domain-containing protein 4", "protein_names_refseq": "leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor; leucine-rich repeat and fibronectin type-III domain-containing protein 4; synaptic adhesion-like molecule 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:225875); (R-MMU-8849932)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16495444;16828986;18227064;18585462;20410109;27480238;30084848;30779550;31219806;32665594", "class_list": "", "function": "Data show that the C-terminal PDZ binding domains of synaptic adhesion-like molecules (SALMs)1-3 are required for neurite outgrowth, and that the N-termini of SALMs 2 and 4 are alsoinvolved in neurite outgrowth., [RefSeq, PubMed]; Expression of SALM family proteins SALM3 and SALM5 in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons., [RefSeq, PubMed]; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery., [UniProtKB, PubMed, PubMed]; SALM4 cis-interacts with SALM3, inhibits trans-synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPsigma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQG8;Q460G5;Q8K3C4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0009986 cell surface;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0099560 synaptic membrane adhesion;GO:1905606 regulation of presynapse assembly;GO:0099151 regulation of postsynaptic density assembly", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q80XU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGS0-1", "uniprot_id": "MAK16_MOUSE", "mass": 35185.0, "length": 296, "protein_name": "Protein MAK16 homolog", "gene_name": "Mak16", "organism": "Mouse", "refseq_name": "protein MAK16 homolog", "refseq_ac": "NP_080729", "gene_names_uniprotkb": "Mak16; Rbm13", "gene_names_refseq": "2600016B03Rik; Mak16; Rbm13", "protein_names_uniprotkb": "Protein MAK16 homolog; Protein RBM13", "protein_names_refseq": "RNA binding motif protein 13; protein MAK16 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67920)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17242355;21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921E0;Q9D5G6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BGS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BI08-1", "uniprot_id": "MAL2_MOUSE", "mass": 19094.0, "length": 175, "protein_name": "Protein MAL2", "gene_name": "Mal2", "organism": "Mouse", "refseq_name": "protein MAL2", "refseq_ac": "NP_849251", "gene_names_uniprotkb": "Mal2", "gene_names_refseq": "Mal2", "protein_names_uniprotkb": "Protein MAL2", "protein_names_refseq": "protein MAL2", "tax_id": 10090, "disease": "", "pathway": " (mmu:105853)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19683524", "class_list": "", "function": "After differentiation, murine oligodendrocyte precursor and human oligodendroglioma derived cell lines up-regulate the expression of MAL2 and accumulate it in an intracellular compartment, exhibiting a peri-centrosomal localization., [RefSeq, PubMed]; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0016020 membrane;GO:0045121 membrane raft;GO:0016324 apical plasma membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BI08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJS7-1", "uniprot_id": "MAP10_MOUSE", "mass": 96155.0, "length": 891, "protein_name": "Microtubule-associated protein 10", "gene_name": "Map10", "organism": "Mouse", "refseq_name": "microtubule-associated protein 10", "refseq_ac": "NP_083184", "gene_names_uniprotkb": "Map10; Kiaa1383", "gene_names_refseq": "4933403G14Rik; Map10; mKIAA1383", "protein_names_uniprotkb": "Microtubule-associated protein 10; Microtubule regulator of 120 KDa", "protein_names_refseq": "microtubule regulator of 120 KDa; microtubule-associated protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:74393)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;31616917", "class_list": "", "function": "Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTY2", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0030496 midbody;GO:0005881 cytoplasmic microtubule;GO:0097431 mitotic spindle pole;GO:1990023 mitotic spindle midzone", "go_biological_process": "GO:0051301 cell division;GO:0032886 regulation of microtubule-based process;GO:0032467 positive regulation of cytokinesis;GO:0051256 mitotic spindle midzone assembly;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BJS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C3X8-1", "uniprot_id": "LMF2_MOUSE", "mass": 79997.0, "length": 702, "protein_name": "Lipase maturation factor 2", "gene_name": "Lmf2", "organism": "Mouse", "refseq_name": "lipase maturation factor 2 isoform 1", "refseq_ac": "NP_849250", "gene_names_uniprotkb": "Lmf2; Tmem112b; Tmem153", "gene_names_refseq": "Lmf2; Tmem112b; Tmem153", "protein_names_uniprotkb": "Lipase maturation factor 2; Transmembrane protein 112B; Transmembrane protein 153", "protein_names_refseq": "lipase maturation factor 2 isoform 1; transmembrane protein 112B; transmembrane protein 153", "tax_id": 10090, "disease": "", "pathway": " (mmu:105847); (R-MMU-8963889)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806;34428180", "class_list": "", "function": "Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C3X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CBC6-1", "uniprot_id": "LRRN3_MOUSE", "mass": 79176.0, "length": 707, "protein_name": "Leucine-rich repeat neuronal protein 3", "gene_name": "Lrrn3", "organism": "Mouse", "refseq_name": "leucine-rich repeat neuronal protein 3 precursor", "refseq_ac": "NP_001258637", "gene_names_uniprotkb": "Lrrn3", "gene_names_refseq": "Lrrn3; NLRR-3", "protein_names_uniprotkb": "Leucine-rich repeat neuronal protein 3; NLRR-3; Neuronal leucine-rich repeat protein 3", "protein_names_refseq": "leucine-rich repeat neuronal protein 3 precursor; leucine-rich repeat neuronal protein 3", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:16981)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;15893969;30899004;9011764", "class_list": "", "function": "Analysis of NLRR-3 expression revealed regulated expression in the neural system in developing ganglia and motor neurons., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "P97860", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030131 clathrin adaptor complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CBC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZL2-1", "uniprot_id": "MCHR1_MOUSE", "mass": 39120.0, "length": 353, "protein_name": "Melanin-concentrating hormone receptor 1", "gene_name": "Mchr1", "organism": "Mouse", "refseq_name": "melanin-concentrating hormone receptor 1", "refseq_ac": "NP_660114", "gene_names_uniprotkb": "Mchr1; Gpr24; Slc1", "gene_names_refseq": "Gpr24; Mch1r; Mchr1", "protein_names_uniprotkb": "Melanin-concentrating hormone receptor 1; G protein-coupled receptor 24; MCH receptor 1; MCH-1R; MCH-R1; MCH1R; MCHR-1; MCHR; SLC-1; Somatostatin receptor-like protein", "protein_names_refseq": "G protein coupled receptor 24; Gpr24-9 protein coupled receptor; MCH receptor 1; MCHR; SLC-1; melanin-concentrating hormone receptor 1; somatostatin receptor-like protein", "tax_id": 10090, "disease": "morbid obesity (Disease Ontology:DOID:11981); Parkinson's disease (Disease Ontology:DOID:14330); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:207911); (R-MMU-375276); (R-MMU-416476); (R-MMU-418594); (R-MMU-5620922)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "11159839;11471062;12072376;15093132;15988472;18380672;33741721;34124835", "class_list": "", "function": "An N-terminal fusion allele to study melanin concentrating hormone receptor 1., [RefSeq, PubMed]; G protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C and mobilize intracellular calcium (By similarity). Predominantly localized within the central nervous system where it regulates various physiological processes including feeding behavior, energy homeostasis, stress/anxiety-related behaviors and sleep (PubMed:12072376, PubMed:15988472, PubMed:18380672)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The Transition Zone Protein AHI1 Regulates Neuronal Ciliary Trafficking of MCHR1 and Its Downstream Signaling Pathway., [RefSeq, PubMed]; The gene encoding the mouse melanin-concentrating hormone receptor 1 was isolated and its structural organization and flanking regions were characterized., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UY93;Q8K3M8", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0042562 hormone binding;GO:0042923 neuropeptide binding;GO:0030273 melanin-concentrating hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043005 neuron projection;GO:0097730 non-motile cilium;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0060259 regulation of feeding behavior;GO:0051928 positive regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8JZL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1C9-1", "uniprot_id": "LRC41_MOUSE", "mass": 88180.0, "length": 807, "protein_name": "Leucine-rich repeat-containing protein 41", "gene_name": "Lrrc41", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 41", "refseq_ac": "NP_705741", "gene_names_uniprotkb": "Lrrc41; Muf1", "gene_names_refseq": "D630045E04Rik; D730026A16Rik; Lrrc41; MUF1", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 41; Protein Muf1", "protein_names_refseq": "leucine-rich repeat-containing protein 41; protein Muf1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230654); (R-MMU-8951664); (R-MMU-9706019); (R-MMU-983168)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11384984;21183079;22709582;22872234;28135057;31219806;34428180", "class_list": "", "function": "Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB]; The authors identified MUF1 as the first substrate for RhoBTB-Cul3 ubiquitin ligase complexes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A911;Q3U3S2;Q6IQY7;Q91VX4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K1C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R001-1", "uniprot_id": "MARE2_MOUSE", "mass": 36946.0, "length": 326, "protein_name": "Microtubule-associated protein RP/EB family member 2", "gene_name": "Mapre2", "organism": "Mouse", "refseq_name": "microtubule-associated protein RP/EB family member 2 isoform 2", "refseq_ac": "NP_001156413", "gene_names_uniprotkb": "Mapre2", "gene_names_refseq": "C820009F03Rik; D18Abb1e; EB1; EB2; Mapre2; RP1", "protein_names_uniprotkb": "Microtubule-associated protein RP/EB family member 2; APC-binding protein EB2; EB2; End-binding protein 2", "protein_names_refseq": "APC-binding protein EB1; APC-binding protein EB2; T-cell activation protein, EB1 family, member 2; end-binding protein 2; microtubule-associated protein RP/EB family member 2 isoform 2", "tax_id": 10090, "disease": "congenital symmetric circumferential skin creases 2 (Disease Ontology:DOID:0112243)", "pathway": " (mmu:212307)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "15789376;17947660;18299400;21646404;21750661;21952136;23813963;26495903;26527684;31219806;33300544;34428180;35398309;36288343;37828378;38319584", "class_list": "", "function": "Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (By similarity). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (PubMed:23813963). Plays a role during oocyte meiosis by regulating microtubule dynamics (PubMed:35398309). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (By similarity). Plays also an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by Regulating MAPRE2 Ubiquitination., [RefSeq, PubMed]; Knockdown of HAX1 and EB2 in skin epidermal cells stabilizes focal adhesions and impairs epidermal migration. Erratum:[J Biol Chem. 2019 Feb 22;294(8):2948. doi: 10.1074/jbc.AAC119.007825. PMID: 30796176], [RefSeq, PubMed]; Thus, we suggest that EB1 could complement MAP1B function during neural development., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF61;Q8BLZ6;Q8BYR6;Q8C177;Q8K109", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0051233 spindle midzone;GO:0015630 microtubule cytoskeleton;GO:0005815 microtubule organizing center;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051301 cell division;GO:0051549 positive regulation of keratinocyte migration;GO:0051225 spindle assembly;GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8R001-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R003-1", "uniprot_id": "MBNL3_MOUSE", "mass": 37570.0, "length": 342, "protein_name": "Muscleblind-like protein 3", "gene_name": "Mbnl3", "organism": "Mouse", "refseq_name": "muscleblind-like protein 3 isoform 1", "refseq_ac": "NP_598924", "gene_names_uniprotkb": "Mbnl3; Chcr; Mbxl", "gene_names_refseq": "A530038J18Rik; CHCR; E430034C16Rik; MBLX39; MBLX; MBXL; Mbnl3", "protein_names_uniprotkb": "Muscleblind-like protein 3; Cys3His CCG1-required protein; Muscleblind-like X-linked protein; Protein MCHCR", "protein_names_refseq": "cys3His CCG1-required protein; muscleblind-like 3; muscleblind-like X-linked protein; muscleblind-like protein 3 isoform 1; muscleblind-like protein 3", "tax_id": 10090, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonic disease (Disease Ontology:DOID:450)", "pathway": " (mmu:171170)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12297108;21750661;31219806", "class_list": "", "function": "Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins (By similarity). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing;GO:0045662 negative regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R003-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCH9-1", "uniprot_id": "LRC3B_MOUSE", "mass": 29261.0, "length": 259, "protein_name": "Leucine-rich repeat-containing protein 3B", "gene_name": "Lrrc3b", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 3B precursor", "refseq_ac": "NP_666164", "gene_names_uniprotkb": "Lrrc3b; Lrp15", "gene_names_refseq": "LRP15; Lrrc3b", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 3B; Leucine-rich repeat protein 15", "protein_names_refseq": "leucine-rich repeat protein 15; leucine-rich repeat protein LRP15; leucine-rich repeat-containing protein 3B precursor; leucine-rich repeat-containing protein 3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:218763)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;24692514", "class_list": "", "function": "Lrrc3b expression is directly and rapidly increased by odor stimulation of mouse olfactory sensory neurons. [Lrrc3b], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VCH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VED9-1", "uniprot_id": "LEGL_MOUSE", "mass": 18956.0, "length": 172, "protein_name": "Galectin-related protein", "gene_name": "Lgalsl", "organism": "Mouse", "refseq_name": "galectin-related protein", "refseq_ac": "NP_776113", "gene_names_uniprotkb": "Lgalsl; Grpa; Lgalsla", "gene_names_refseq": "1110067D22Rik; A530071M23; Grpa; Hspc159; Lgalsla; Lgalsl", "protein_names_uniprotkb": "Galectin-related protein; Galectin-related protein A; Lectin galactoside-binding-like protein A", "protein_names_refseq": "galectin-related protein A; galectin-related protein; lectin galactoside-binding-like protein A; lectin, galactoside binding-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:216551)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene", "function": "Does not bind lactose, and may not bind carbohydrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4P8", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VED9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91X49-1", "uniprot_id": "MALL_MOUSE", "mass": 17470.0, "length": 154, "protein_name": "MAL-like protein", "gene_name": "Mall", "organism": "Mouse", "refseq_name": "MAL-like protein", "refseq_ac": "NP_663507", "gene_names_uniprotkb": "Mall; Bene", "gene_names_refseq": "BENE; Mall", "protein_names_uniprotkb": "MAL-like protein; Protein BENE", "protein_names_refseq": "MAL-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:228576)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "33672337", "class_list": "", "function": "Runx3 Induces a Cell Shape Change and Suppresses Migration and Metastasis of Melanoma Cells by Altering a Transcriptional Profile. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ65", "ec_number_list": "", "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045121 membrane raft;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91X49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KG5-1", "uniprot_id": "LSR_MOUSE", "mass": 66108.0, "length": 594, "protein_name": "Lipolysis-stimulated lipoprotein receptor", "gene_name": "Lsr", "organism": "Mouse", "refseq_name": "lipolysis-stimulated lipoprotein receptor isoform 2 precursor", "refseq_ac": "NP_001157656", "gene_names_uniprotkb": "Lsr; Ildr3; Lisch7", "gene_names_refseq": "ILDR3; Lisch7; Lsr", "protein_names_uniprotkb": "Lipolysis-stimulated lipoprotein receptor; Angulin-3; Lipolysis-stimulated receptor; Liver-specific bHLH-Zip transcription factor; Liver-specific gene on mouse chromosome 7 protein", "protein_names_refseq": "angulin-3; lipolysis stimulated receptor; lipolysis-stimulated lipoprotein receptor isoform 2 precursor; liver-specific bHLH-Zip transcription factor; liver-specific gene on mouse chromosome 7 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:54135)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15265030;17242355;18322192;21183079;21245199;21750661;23239027;24889144;26740625;30250217;34428180;35820727;37703178", "class_list": "", "function": "Expression of LSR is critical for liver and embryonic development [LSR], [RefSeq, PubMed]; LSR targets YAP to modulate intestinal Paneth cell differentiation., [RefSeq, PubMed]; Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (PubMed:15265030). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (PubMed:21245199, PubMed:23239027)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJE7;Q3UIQ9;Q61148;Q61149;Q6U816", "ec_number_list": "", "go_molecular_function": "GO:0030169 low-density lipoprotein particle binding;GO:0030228 lipoprotein particle receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030054 cell junction;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:0060856 establishment of blood-brain barrier;GO:0061833 protein localization to tricellular tight junction;GO:1904274 tricellular tight junction assembly;GO:0001889 liver development;GO:0042953 lipoprotein transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99KG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N10-3", "uniprot_id": "M4A8_MOUSE", "mass": 30858.0, "length": 290, "protein_name": "Membrane-spanning 4-domains subfamily A member 8", "gene_name": "Ms4a8", "organism": "Mouse", "refseq_name": "membrane-spanning 4-domains subfamily A member 8", "refseq_ac": "NP_071875", "gene_names_uniprotkb": "Ms4a8; Cd20l5; Ms4a8a", "gene_names_refseq": "2010004L09Rik; CD20L5; Ms4a8a; Ms4a8", "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 8; CD20 antigen-like 5; Membrane-spanning 4-domains subfamily A member 8A", "protein_names_refseq": "CD20 antigen-like 5; MS4a8B protein; membrane-spanning 4-domains subfamily A member 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:64381)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11245982;11401424;23348583", "class_list": "", "function": "MS4A8A is a novel differentiation marker of the intestinal epithelium that supports the maintenance of a physiological barrier function in the gut by modulating the transcriptome and by conferring an increased resistance to reactive oxygen species. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in signal transduction as a component of a multimeric receptor complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8WIR2;Q2TVW6;Q3T990;Q8CG94;Q9EQZ0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99N10-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPW9-1", "uniprot_id": "MAP12_MOUSE", "mass": 37262.0, "length": 335, "protein_name": "Methionine aminopeptidase 1D, mitochondrial", "gene_name": "Metap1d", "organism": "Mouse", "refseq_name": "methionine aminopeptidase 1D, mitochondrial isoform 3 precursor", "refseq_ac": "NP_079909", "gene_names_uniprotkb": "Metap1d; Map1d; Metapl1; Mnpepl", "gene_names_refseq": "2310066F24Rik; 3110033D18Rik; MAP 1D; Map1d; MetAP 1D; Metap1d; Metapl1", "protein_names_uniprotkb": "Methionine aminopeptidase 1D, mitochondrial; 3.4.11.18; MAP 1D; MetAP 1D; Methionyl aminopeptidase type 1D, mitochondrial; Peptidase M 1D", "protein_names_refseq": "metAP 1D; methionine aminopeptidase 1D, mitochondrial isoform 3 precursor; methionine aminopeptidase 1D, mitochondrial; methionine aminopeptidase-like 1; peptidase M 1D", "tax_id": 10090, "disease": "", "pathway": " (mmu:66559)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20485683;22872234;34203471;34428180", "class_list": "", "function": "Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80WB3;Q91YD2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006508 proteolysis;GO:0043687 post-translational protein modification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CPW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR33-1", "uniprot_id": "MANS1_MOUSE", "mass": 44823.0, "length": 414, "protein_name": "MANSC domain-containing protein 1", "gene_name": "Mansc1", "organism": "Mouse", "refseq_name": "MANSC domain-containing protein 1 precursor", "refseq_ac": "NP_080621", "gene_names_uniprotkb": "Mansc1", "gene_names_refseq": "9130403P13Rik; Mansc1", "protein_names_uniprotkb": "MANSC domain-containing protein 1", "protein_names_refseq": "MANSC domain-containing protein 1 precursor; MANSC domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67729)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q80V71", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CR33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4C6-1", "uniprot_id": "LR2BP_MOUSE", "mass": 39746.0, "length": 346, "protein_name": "LRP2-binding protein", "gene_name": "Lrp2bp", "organism": "Mouse", "refseq_name": "LRP2-binding protein", "refseq_ac": "NP_080554", "gene_names_uniprotkb": "Lrp2bp", "gene_names_refseq": "1700113N17Rik; 2310006J04Rik; 4930479L12Rik; Lrp2bp; MegBP", "protein_names_uniprotkb": "LRP2-binding protein", "protein_names_refseq": "LRP2-binding protein; megalin-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67620)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May act as an adapter that regulates LRP2 function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UV46;Q8CF18;Q8K0N7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7F2-2", "uniprot_id": "LPD6B_MOUSE", "mass": 19528.0, "length": 172, "protein_name": "Ly6/PLAUR domain-containing protein 6B", "gene_name": "Lypd6b", "organism": "Mouse", "refseq_name": "ly6/PLAUR domain-containing protein 6B precursor", "refseq_ac": "NP_001366310", "gene_names_uniprotkb": "Lypd6b", "gene_names_refseq": "2310010M24Rik; Lypd6b", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 6B", "protein_names_refseq": "ly6/PLAUR domain-containing protein 6B precursor; ly6/PLAUR domain-containing protein 6B", "tax_id": 10090, "disease": "", "pathway": " (mmu:71897); (R-MMU-163125)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;37833597", "class_list": "", "function": "Accumulation of beta-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum., [RefSeq, PubMed]; Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence. However, according to another report in vitro it can weakly inhibits alpha-7 nAChRs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JNT6", "ec_number_list": "", "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D7F2-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7V2-1", "uniprot_id": "LYSM2_MOUSE", "mass": 23694.0, "length": 215, "protein_name": "LysM and putative peptidoglycan-binding domain-containing protein 2", "gene_name": "Lysmd2", "organism": "Mouse", "refseq_name": "lysM and putative peptidoglycan-binding domain-containing protein 2 isoform X1", "refseq_ac": "XP_006511494", "gene_names_uniprotkb": "Lysmd2", "gene_names_refseq": "2210402C18Rik; Lysmd2", "protein_names_uniprotkb": "LysM and putative peptidoglycan-binding domain-containing protein 2", "protein_names_refseq": "lysM and putative peptidoglycan-binding domain-containing protein 2 isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70082)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZR2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8U6-1", "uniprot_id": "MCEM1_MOUSE", "mass": 20649.0, "length": 183, "protein_name": "Mast cell-expressed membrane protein 1", "gene_name": "Mcemp1", "organism": "Mouse", "refseq_name": "mast cell-expressed membrane protein 1", "refseq_ac": "NP_081261", "gene_names_uniprotkb": "Mcemp1", "gene_names_refseq": "1810033B17Rik; Mcemp1", "protein_names_uniprotkb": "Mast cell-expressed membrane protein 1", "protein_names_refseq": "mast cell-expressed membrane protein 1 homolog; mast cell-expressed membrane protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69189); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "29187734;30084848;30883005;37041174", "class_list": "", "function": "High Mcemp1 expression is associated with sepsis., [RefSeq, PubMed]; Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0038109 Kit signaling pathway;GO:0070662 mast cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D8U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBN5-1", "uniprot_id": "LONP2_MOUSE", "mass": 94526.0, "length": 852, "protein_name": "Lon protease homolog 2, peroxisomal", "gene_name": "Lonp2", "organism": "Mouse", "refseq_name": "lon protease homolog 2, peroxisomal isoform 2", "refseq_ac": "NP_001162063", "gene_names_uniprotkb": "Lonp2", "gene_names_refseq": "1300002A08Rik; Lonp2; Lonp", "protein_names_uniprotkb": "Lon protease homolog 2, peroxisomal; 3.4.21.53; Lon protease 2; Lon protease-like protein 2; Peroxisomal Lon protease", "protein_names_refseq": "lon protease 2; lon protease homolog 2, peroxisomal isoform 2; lon protease homolog 2, peroxisomal; lon protease-like protein 2; peroxisomal Lon protease homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66887); (R-MMU-9033241)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19224205;20173027;31219806;34203471;34428180;35820727", "class_list": "", "function": "ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEG8;Q3TFY6;Q3TGR0;Q3UAE1", "ec_number_list": "2.3.2.27;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.1.42;3.6.4.13;1.5.3.13;2.3.1.65;1.4.3.1;4.1.1.9;3.4.19.12;1.1.1.300;1.1.1.184;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;3.1.13.-;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124;5.2.1.8", "go_molecular_function": "GO:0002020 protease binding;GO:0004252 serine-type endopeptidase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0016485 protein processing;GO:0006625 protein targeting to peroxisome;GO:0016558 protein import into peroxisome matrix;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0031998 regulation of fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DBN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCJ1-1", "uniprot_id": "LST8_MOUSE", "mass": 35851.0, "length": 326, "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "Mlst8", "organism": "Mouse", "refseq_name": "target of rapamycin complex subunit LST8 isoform 1", "refseq_ac": "NP_001239392", "gene_names_uniprotkb": "Mlst8; Gbl; Lst8", "gene_names_refseq": "0610033N12Rik; Gbl; Mlst8", "protein_names_uniprotkb": "Target of rapamycin complex subunit LST8; G protein beta subunit-like; Mammalian lethal with SEC13 protein 8; Protein GbetaL; TORC subunit LST8; mLST8", "protein_names_refseq": "TORC subunit LST8; mammalian lethal with SEC13 protein 8; protein GbetaL; target of rapamycin complex subunit LST8 isoform 1; target of rapamycin complex subunit LST8; transducin (beta)-like 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:56716); (R-MMU-1257604); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-3371571); (R-MMU-380972); (R-MMU-389357); (R-MMU-5218920); (R-MMU-5628897); (R-MMU-6804757); (R-MMU-8943724); (R-MMU-9639288); (R-MMU-9856530)", "pathway_count": 14, "publication_count": 10, "publication_id_list": "11182770;12718876;16797547;17141160;20801936;21750661;28489822;30779550;38395307;39388284", "class_list": "", "function": "Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy. The mTORC1 complex is inhibited in response to starvation and amino acid depletion. Within mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. As part of the mTORC2 complex, transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. mTORC2 functions upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MLST8 acts as a bridge between MAPKAP1/SIN1 and MTOR., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; The mutant, Gbeta1(W332A) protein, although inactive, retains its ability to bind Kir3 and prevents the wild type Gbeta from activating the channel., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNG8;Q8C882;Q9JKK6", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0030674 protein-macromolecule adaptor activity;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005737 cytoplasm;GO:0005765 lysosomal membrane;GO:0031931 TORC1 complex;GO:0031932 TORC2 complex", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0032956 regulation of actin cytoskeleton organization;GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0046889 positive regulation of lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9DCJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESL4-1", "uniprot_id": "M3K20_MOUSE", "mass": 91720.0, "length": 802, "protein_name": "Mitogen-activated protein kinase kinase kinase 20", "gene_name": "Map3k20", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 20 isoform 3", "refseq_ac": "NP_001158263", "gene_names_uniprotkb": "Map3k20; B230120H23Rik; Mltk; Zak", "gene_names_refseq": "B230120H23Rik; HCCS-4; MLTKalpha; MLTKbeta; MLTK; MRK; Map3k20; Zak", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 20; 2.7.11.25; Leucine zipper- and sterile alpha motif kinase ZAK; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; MRK; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase-related kinase; Sterile alpha motif- and leucine zipper-containing kinase AZK", "protein_names_refseq": "MLK-like mitogen-activated protein triple kinase; MLK-related kinase; human cervical cancer suppressor gene 4 protein; leucine zipper- and sterile alpha motif kinase ZAK; leucine zipper- and sterile alpha motif-containing kinase; mitogen-activated protein kinase kinase kinase 20 isoform 3; mitogen-activated protein kinase kinase kinase MLT; mixed lineage kinase-related kinase; sterile alpha motif and leucine zipper containing kinase AZK", "tax_id": 10090, "disease": "split hand-foot malformation (Disease Ontology:DOID:0090020); centronuclear myopathy 6 with fiber-type disproportion (Disease Ontology:DOID:0111221)", "pathway": " (mmu:65964)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11042189;12761180;15684425;19144319;21183079;21750661;25428506;26755636;27598200;32289254;34428180;37427997;37507081", "class_list": "", "function": "Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress. May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha., [UniProtKB, UniProtKB]; Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR) (PubMed:32289254). Directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (By similarity). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (By similarity). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (By similarity). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (By similarity). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (By similarity)., [UniProtKB, UniProtKB, PubMed]; Myofibrillar myopathy hallmarks associated with ZAK deficiency. Erratum:[Hum Mol Genet. 2023 Dec 1;32(24):3390. doi: 10.1093/hmg/ddad168. PMID: 37788121], [RefSeq, PubMed]; PKNalpha functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein for the p38gamma MAPK signaling pathway, [RefSeq, PubMed]; Results show that mixed lineage kinase-like mitogen-activated protein triple kinase (MLTK_-alpha plays a key role in the UVB- and EGF-induced phosphorylation of histone H3 at Ser28., [RefSeq, PubMed]; Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:11042189, PubMed:27598200). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11042189). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (By similarity). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1X8;Q8BR73;Q9ESL3", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030295 protein kinase activator activity;GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:1904784 NLRP1 inflammasome complex assembly;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9ESL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NWG9-1", "uniprot_id": "MAGH1_MOUSE", "mass": 24325.0, "length": 218, "protein_name": "Melanoma-associated antigen H1", "gene_name": "Mageh1", "organism": "Mouse", "refseq_name": "melanoma-associated antigen H1", "refseq_ac": "NP_076277", "gene_names_uniprotkb": "Mageh1", "gene_names_refseq": "2010107K23Rik; APR-1; APR1; Mageh1", "protein_names_uniprotkb": "Melanoma-associated antigen H1; MAGE-H1 antigen", "protein_names_refseq": "MAGE-H1 antigen; melanoma antigen, family H, 1; melanoma-associated antigen H1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75625)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "30084848;30779550;34203471;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99PB0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9NWG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTZ2-1", "uniprot_id": "MBTP1_MOUSE", "mass": 117457.0, "length": 1052, "protein_name": "Membrane-bound transcription factor site-1 protease", "gene_name": "Mbtps1", "organism": "Mouse", "refseq_name": "membrane-bound transcription factor site-1 protease precursor", "refseq_ac": "NP_001161382", "gene_names_uniprotkb": "Mbtps1; S1p; Ski1", "gene_names_refseq": "0610038M03Rik; Mbtps1; S1P; SKI-1; Ski1; mKIAA0091", "protein_names_uniprotkb": "Membrane-bound transcription factor site-1 protease; 3.4.21.112; Endopeptidase S1P; SKI-1; Sterol-regulated luminal protease; Subtilisin/kexin isozyme 1", "protein_names_refseq": "S1P endopeptidase; endopeptidase S1P; membrane-bound transcription factor protease, site 1; membrane-bound transcription factor site-1 protease precursor; membrane-bound transcription factor site-1 protease; sterol-regulated luminal protease; subtilisin/kexin isozyme 1; subtilisin/kexin isozyme SKI-1", "tax_id": 10090, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); spondyloepiphyseal dysplasia Kondo-Fu type (Disease Ontology:DOID:0112283)", "pathway": " (mmu:56453); (R-MMU-1655829); (R-MMU-381033); (R-MMU-381426); (R-MMU-8874177); (R-MMU-8874211); (R-MMU-8957275)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12180344;26495903;31219806;34349020;34428180;35362222;36776855;37002920;37828378;38243371;38359126;9990022", "class_list": "", "function": "Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG., [RefSeq, PubMed]; Located distally on chromosome 8., [RefSeq, PubMed]; Serine protease that cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4: known substrates include SREBF1/SREBP1, SREBF2/SREBP2, BDNF, GNPTAB, ATF6, ATF6B and FAM20C (By similarity). Cleaves substrates after Arg-Ser-Val-Leu (SREBP2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu (By similarity). Catalyzes the first step regulated intramembrane proteolysis activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). Also mediates the first step of the regulated intramembrane proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (By similarity). Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes (By similarity). Cleaves the propeptide from FAM20C which is required for FAM20C secretion from the Golgi apparatus membrane and for enhancement of FAM20C kinase activity, promoting osteoblast differentiation and biomineralization (PubMed:34349020). Involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes (By similarity). It is required for the activation of CREB3L2/BBF2H7, a transcriptional activator of MIA3/TANGO and other genes controlling mega vesicle formation (By similarity). Therefore, it plays a key role in the regulation of mega vesicle-mediated collagen trafficking (By similarity). Promotes FAD binding to the ETFA/ETFB complex and is therefore involved in mitochondrial respiratory chain regulation (By similarity). In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the first step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression (By similarity)., [UniProtKB, UniProtKB, PubMed]; Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3-SOD2-mtROS signaling., [RefSeq, PubMed]; Site-1 protease inhibits mitochondrial respiration by controlling the TGF-beta target gene Mss51., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q6PG67", "ec_number_list": "3.4.24.81;3.6.4.-;5.3.4.1;3.4.21.69;2.7.11.1;1.11.1.27;1.16.3.1;1.11.1.9;1.16.3.4;3.4.21.-;2.4.1.145;3.1.1.4;3.1.1.3;1.8.3.2;3.4.24.85;3.1.1.98;3.2.1.51;3.4.21.112", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006629 lipid metabolic process;GO:0008203 cholesterol metabolic process;GO:0016485 protein processing;GO:0045542 positive regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9WTZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUH2-3", "uniprot_id": "LHX9_MOUSE", "mass": 44045.0, "length": 397, "protein_name": "LIM/homeobox protein Lhx9", "gene_name": "Lhx9", "organism": "Mouse", "refseq_name": "LIM/homeobox protein Lhx9 isoform a", "refseq_ac": "NP_001020736", "gene_names_uniprotkb": "Lhx9", "gene_names_refseq": "3110009O07Rik; LH2B; Lhx9", "protein_names_uniprotkb": "LIM/homeobox protein Lhx9; LIM homeobox protein 9", "protein_names_refseq": "LIM/homeobox protein Lhx9 isoform a; LIM/homeobox protein Lhx9", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:16876)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10330499;10706291;10756098;38438260;9880598", "class_list": "", "function": "Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in gonadal development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GQU4;Q9QYQ5;Q9QYQ6;Q9QZ00;Q9WU44", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription;GO:0008584 male gonad development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WUH2-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUL6-1", "uniprot_id": "M3K14_MOUSE", "mass": 103080.0, "length": 942, "protein_name": "Mitogen-activated protein kinase kinase kinase 14", "gene_name": "Map3k14", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase 14", "refseq_ac": "NP_058592", "gene_names_uniprotkb": "Map3k14; Nik", "gene_names_refseq": "Map3k14; Nik; aly", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 14; 2.7.11.25; NF-kappa-beta-inducing kinase; Serine/threonine-protein kinase NIK", "protein_names_refseq": "NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; alymphoplasia; mitogen-activated protein kinase kinase kinase 14; serine/threonine-protein kinase NIK", "tax_id": 10090, "disease": "immunodeficiency 112 (Disease Ontology:DOID:0061079); primary biliary cholangitis (Disease Ontology:DOID:12236); Sjogren's syndrome (Disease Ontology:DOID:12894)", "pathway": " (mmu:53859); (R-MMU-389357); (R-MMU-5607761); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5676594)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10319865;11239468;23023393;26029823;34428180;37165186;37459681;38750899;39019135", "class_list": "", "function": "EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia., [RefSeq, PubMed]; High expression of NF-kappaB inducing kinase in the bulge region of hair follicle induces tumor., [RefSeq, PubMed]; Inhibiting NF-kappaB inducing kinase improved the motor performance of ALS animal model., [RefSeq, PubMed]; Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA (By similarity). Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway (PubMed:11239468). Has an essential role in the non-canonical NF-kappa-B signalining that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (By similarity). Could act in a receptor-selective manner., [UniProtKB, UniProtKB, PubMed]; NF-kappaB Inducing Kinase Attenuates Colorectal Cancer by Regulating Noncanonical NF-kappaB Mediated Colonic Epithelial Cell Regeneration., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.3.2.27;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;3.4.19.12;2.7.10.2;2.7.11.-;2.7.11.4;3.4.25.1;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.3.2.34;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;6.2.1.64;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006955 immune response;GO:0051607 defense response to virus;GO:0000165 MAPK cascade;GO:0071260 cellular response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WUL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0M5-1", "uniprot_id": "LICH_MOUSE", "mass": 45325.0, "length": 397, "protein_name": "Lysosomal acid lipase/cholesteryl ester hydrolase", "gene_name": "Lipa", "organism": "Mouse", "refseq_name": "lysosomal acid lipase/cholesteryl ester hydrolase precursor", "refseq_ac": "NP_001104570", "gene_names_uniprotkb": "Lipa; Lip1", "gene_names_refseq": "Lal; Lip-1; Lip1; Lipa", "protein_names_uniprotkb": "Lysosomal acid lipase/cholesteryl ester hydrolase; 3.1.1.13; Acid cholesteryl ester hydrolase; Cholesteryl esterase; Diacylglycerol lipase; LAL; Lipase A; Sterol esterase; Triacylglycerol ester hydrolase; Triacylglycerol lipase", "protein_names_refseq": "acid cholesteryl ester hydrolase; cholesteryl esterase; diacylglycerol lipase; lipase A; lysosomal acid lipase 1; lysosomal acid lipase A; lysosomal acid lipase/cholesteryl ester hydrolase precursor; lysosomal acid lipase/cholesteryl ester hydrolase; sterol esterase; triacylglycerol ester hydrolase; triacylglycerol lipase", "tax_id": 10090, "disease": "lysosomal acid lipase deficiency (Disease Ontology:DOID:0080217); Wolman disease (Disease Ontology:DOID:14497); cholesterol ester storage disease (Disease Ontology:DOID:14502)", "pathway": " (mmu:16889); (R-MMU-8964038)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;31219806;34428180;36210013;37828378;8725147", "class_list": "glycogene", "function": "Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. Hydrolyzes triglycerides (1,2,3-triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3-diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 9296, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2G7", "ec_number_list": "3.1.1.23;3.1.1.79;3.1.1.4;3.1.1.3;3.1.1.5;3.1.1.13;3.1.1.6;3.1.1.-;3.1.1.71;3.1.1.1;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0016298 lipase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center;GO:0005764 lysosome", "go_biological_process": "GO:0006638 neutral lipid metabolic process;GO:1903409 reactive oxygen species biosynthetic process;GO:0000278 mitotic cell cycle;GO:0001523 retinoid metabolic process;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z0M5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2E1-1", "uniprot_id": "MBD2_MOUSE", "mass": 43501.0, "length": 414, "protein_name": "Methyl-CpG-binding domain protein 2", "gene_name": "Mbd2", "organism": "Mouse", "refseq_name": "methyl-CpG-binding domain protein 2 isoform 2", "refseq_ac": "NP_001298000", "gene_names_uniprotkb": "Mbd2", "gene_names_refseq": "MBD2a; Mbd2", "protein_names_uniprotkb": "Methyl-CpG-binding domain protein 2; Methyl-CpG-binding protein MBD2", "protein_names_refseq": "methyl-CpG-binding domain protein 2 isoform 2; methyl-CpG-binding protein MBD2; testis-specific methyl-CpG binding protein 2", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); choline deficiency disease (Disease Ontology:DOID:8456); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:17191); (R-MMU-9937850); (R-MMU-9940951)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10441743;14610093;21750661;28135057;37443311;38556549;38578557;9774669", "class_list": "", "function": "Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (By similarity). Recruits histone deacetylases and DNA methyltransferases to chromatin (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Acts as transcriptional repressor and plays a role in gene silencing (By similarity). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (By similarity). May enhance the activation of some unmethylated cAMP-responsive promoters (By similarity). Selectively represses transcription activity of methylated rRNA promoters (PubMed:14610093)., [UniProtKB, UniProtKB, PubMed, PubMed]; Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition. Publication Status: Online-Only, [RefSeq, PubMed]; Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition., [RefSeq, PubMed]; Proximal tubular MBD2 promotes autophagy to drive the progression of AKI caused by vancomycin via regulation of miR-597-5p/S1PR1 axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMV9;Q811D9;Q9Z2D9", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z2E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BP48-1", "uniprot_id": "MAP11_MOUSE", "mass": 43221.0, "length": 386, "protein_name": "Methionine aminopeptidase 1", "gene_name": "Metap1", "organism": "Mouse", "refseq_name": "methionine aminopeptidase 1", "refseq_ac": "NP_780433", "gene_names_uniprotkb": "Metap1", "gene_names_refseq": "1700029C17Rik; Metap1; mKIAA0094", "protein_names_uniprotkb": "Methionine aminopeptidase 1; 3.4.11.18; MAP 1; MetAP 1; Peptidase M 1", "protein_names_refseq": "MAP 1; Putative methionine aminopeptidase 1 (MetAP 1) (Peptidase M 1); metAP 1; methionine aminopeptidase 1; peptidase M 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75624); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28528544;34428180;35584675;35584702", "class_list": "", "function": "Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)., [UniProtKB, HAMAP, PubMed]; Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.11.18;3.6.5.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BP48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3KNM2-1", "uniprot_id": "MARH5_MOUSE", "mass": 31232.0, "length": 278, "protein_name": "E3 ubiquitin-protein ligase MARCHF5", "gene_name": "Marchf5", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MARCHF5 isoform 2", "refseq_ac": "NP_001157808", "gene_names_uniprotkb": "Marchf5; March5", "gene_names_refseq": "1810015H18Rik; 2310008I22Rik; 2700055A20Rik; 5730499H23Rik; E130202O05Rik; MARCH-V; MITOL; March5; Marchf5; Marchv; Rnf153", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF5; 2.3.2.27; MARCH-V; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; RING-type E3 ubiquitin transferase MARCHF5", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH5; E3 ubiquitin-protein ligase MARCHF5 isoform 2; E3 ubiquitin-protein ligase MARCHF5; RING-type E3 ubiquitin transferase MARCH5; RING-type E3 ubiquitin transferase MARCHF5; membrane-associated RING finger protein 5; membrane-associated RING-CH protein V; membrane-associated ring finger (C3HC4) 5; ring finger protein 153", "tax_id": 10090, "disease": "", "pathway": " (mmu:69104)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19741096;21625535;21750661;24722297;36329234;37575012;37932447;38171238;38238476", "class_list": "", "function": "A fine balance of Mfn1 levels is maintained by MARCH5-mediated quality control on acetylated Mfn1. Publication Status: Online-Only, [RefSeq, PubMed]; Irisin improves diabetic cardiomyopathy-induced cardiac remodeling by regulating GSDMD-mediated pyroptosis through MITOL/STING signaling., [RefSeq, PubMed]; MARCH5 is an authentic E3 ubiquitin ligase and catalyzes K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7 signaling via releasing the inhibitory action of TANK toward TRAF6., [RefSeq, PubMed]; MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response., [RefSeq, PubMed]; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission and as an important regulator of immune response. Plays a crucial role in maintaining mitochondrial homeostasis by regulating the dynamics of mitochondria through the ubiquitination of key proteins involved in fission and fusion such as FIS1, DNM1L and MFN1 (By similarity). Acts as a critical determinant of mitotic apoptosis through both MCL1-dependent and -independent pathways (PubMed:36329234). Turns off persistent immune signaling by degrading oligomeric complexes of retinoic acid-inducible gene I/DDX58 and mitochondrial antiviral-signaling protein/MAVS formed upon RNA virus infection. Promotes STING-mediated type-I interferon production via 'Lys-63'-linked ubiquitination of STING1 thereby preserving its activity and preventing the formation of inactive STING1 polymers. Plays also an essential role in the formation of PEX3-containing vesicles in the de novo biogenesis of peroxisomes from mitochondria. Acts as a regulator of NLRP3 inflammasome activation on the mitochondria by mediating the 'Lys-27'-linked polyubiquitination of NLRP3, positively regulating the NLRP3-NEK7 complex formation and NLRP3 oligomerization (PubMed:37575012)., [UniProtKB, UniProtKB, PubMed, PubMed]; PD-1 signaling negatively regulates the common cytokine receptor gamma chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity., [RefSeq, PubMed]; Results indicate that MITOL plays a protective role against mitochondrial dysfunction caused by the mitochondrial accumulation of mSOD1 via the ubiquitin-proteasome pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNM3;Q6P230;Q9CPS3;Q9CTI6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051020 GTPase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0070585 protein localization to mitochondrion;GO:0044546 NLRP3 inflammasome complex assembly;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3KNM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3THS6-1", "uniprot_id": "METK2_MOUSE", "mass": 43689.0, "length": 395, "protein_name": "S-adenosylmethionine synthase isoform type-2", "gene_name": "Mat2a", "organism": "Mouse", "refseq_name": "S-adenosylmethionine synthase isoform type-2 isoform 1", "refseq_ac": "NP_663544", "gene_names_uniprotkb": "Mat2a", "gene_names_refseq": "D630045P18Rik; MAT 2; Mat2a", "protein_names_uniprotkb": "S-adenosylmethionine synthase isoform type-2; 2.5.1.6; AdoMet synthase 2; MAT 2; Methionine adenosyltransferase 2", "protein_names_refseq": "S-adenosylmethionine synthase isoform type-2 isoform 1; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2; methionine adenosyltransferase II, alpha", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); lung cancer (Disease Ontology:DOID:1324); lipid metabolism disorder (Disease Ontology:DOID:3146); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:232087); (R-MMU-156581)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17631143;20043323;21750661;22645316;25153642;29262316;34428180;35422502;35729157;35820727;37453647", "class_list": "", "function": "Catalyzes the formation of S-adenosylmethionine from methionine and ATP., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate., [UniProtKB, UniProtKB]; Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA. Erratum:[Signal Transduct Target Ther. 2022 Dec 28;7(1):401. doi: 10.1038/s41392-022-01255-w. PMID: 36577756] Publication Status: Online-Only, [RefSeq, PubMed]; Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome. Erratum:[Nat Cancer. 2022 Jul;3(7):899. doi: 10.1038/s43018-022-00407-9. PMID: 35739422], [RefSeq, PubMed]; MAT2A and MAT2beta genes are induced during hepatic stellate cell activation, [RefSeq, PubMed]; Up-regulation of MAT2A also provides a growth advantage and s-adenosylmethionine and methylthioadenosine can block mitogenic signaling in colon cancer cells. Erratum:[Gastroenterology. 2007 Nov;133(5):1747], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TL60;Q76LX3", "ec_number_list": "2.5.1.6", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016597 amino acid binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005829 cytosol;GO:0048269 methionine adenosyltransferase complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0051291 protein heterooligomerization;GO:1990830 cellular response to leukemia inhibitory factor;GO:0031669 cellular response to nutrient levels;GO:0006730 one-carbon metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3THS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DIB5-1", "uniprot_id": "MEG10_MOUSE", "mass": 122972.0, "length": 1147, "protein_name": "Multiple epidermal growth factor-like domains protein 10", "gene_name": "Megf10", "organism": "Mouse", "refseq_name": "multiple epidermal growth factor-like domains protein 10 precursor", "refseq_ac": "NP_001001979", "gene_names_uniprotkb": "Megf10", "gene_names_refseq": "3000002B06Rik; Gm331; Megf10", "protein_names_uniprotkb": "Multiple epidermal growth factor-like domains protein 10; Multiple EGF-like domains protein 10", "protein_names_refseq": "multiple EGF-like domains protein 10; multiple epidermal growth factor-like domains protein 10 precursor; multiple epidermal growth factor-like domains protein 10", "tax_id": 10090, "disease": "congenital myopathy 10B (Disease Ontology:DOID:0081345); congenital myopathy 10A (Disease Ontology:DOID:0111333); neurodegenerative disease (Disease Ontology:DOID:1289); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:70417)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;17205124;17643423;18056409;20828568;21750661;22407321;22993420;27170117;28498977;35820727;38760872;40885482", "class_list": "", "function": "Cellular and molecular alterations to muscles and neuromuscular synapses in a mouse model of MEGF10-related myopathy. Publication Status: Online-Only, [RefSeq, PubMed]; In mouse, two related transmembrane proteins, MEGF10 and MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells Publication Status: Online-Only, [RefSeq, PubMed]; Megf10 represents a novel transmembrane protein that impinges on Notch signaling to regulate the satellite cell population balance between proliferation and differentiation., [RefSeq, PubMed]; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment (By similarity). Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays a role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977, Ref.10). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:22407321)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; These results indicated that both Jedi-1 and MEGF10 can mediate phagocytosis independently through the recruitment of Syk., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLU3;Q3UG73", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005112 Notch binding;GO:0001849 complement component C1q complex binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005886 plasma membrane", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0014816 skeletal muscle satellite cell differentiation;GO:0034109 homotypic cell-cell adhesion;GO:0043652 engulfment of apoptotic cell;GO:0051451 myoblast migration", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q6DIB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1N1-1", "uniprot_id": "MFHA1_MOUSE", "mass": 116599.0, "length": 1048, "protein_name": "Malignant fibrous histiocytoma-amplified sequence 1 homolog", "gene_name": "Mfhas1", "organism": "Mouse", "refseq_name": "malignant fibrous histiocytoma-amplified sequence 1 homolog isoform 1", "refseq_ac": "NP_001074748", "gene_names_uniprotkb": "Mfhas1", "gene_names_refseq": "2310066G09Rik; D8Ertd91e; Mfhas1", "protein_names_uniprotkb": "Malignant fibrous histiocytoma-amplified sequence 1 homolog", "protein_names_refseq": "malignant fibrous histiocytoma-amplified sequence 1 homolog isoform 1; malignant fibrous histiocytoma-amplified sequence 1 homolog", "tax_id": 10090, "disease": "fibrous histiocytoma (Disease Ontology:DOID:4415)", "pathway": " (mmu:52065)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20616063;21750661;26599367;27783989;28609714;34203471", "class_list": "", "function": "Colorectal carcinoma cells induce M2 polarization of tumor-associated macrophagess through MFHAS1 induction and subsequent STAT6 and KLF4 activation to promote CRC progression., [RefSeq, PubMed]; Probable GTP-binding protein (By similarity). Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways (PubMed:20616063, PubMed:26599367). Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (By similarity). Both inhibits and activates the TLR2-dependent signaling pathway (PubMed:26599367). Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype. It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway. Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAN2;Q8C4N5", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0031625 ubiquitin protein ligase binding;GO:0051721 protein phosphatase 2A binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0034136 negative regulation of toll-like receptor 2 signaling pathway;GO:0006952 defense response;GO:0006954 inflammatory response;GO:0034121 regulation of toll-like receptor signaling pathway;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3V1N1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C7H1-1", "uniprot_id": "MMAA_MOUSE", "mass": 45932.0, "length": 415, "protein_name": "Methylmalonic aciduria type A homolog, mitochondrial", "gene_name": "Mmaa", "organism": "Mouse", "refseq_name": "methylmalonic aciduria type A homolog, mitochondrial isoform a precursor", "refseq_ac": "NP_598584", "gene_names_uniprotkb": "Mmaa", "gene_names_refseq": "2810018E08Rik; Mmaa", "protein_names_uniprotkb": "Methylmalonic aciduria type A homolog, mitochondrial; 3.6.-.-", "protein_names_refseq": "methylmalonic aciduria type A homolog, mitochondrial isoform a precursor; methylmalonic aciduria type A homolog, mitochondrial", "tax_id": 10090, "disease": "methylmalonic acidemia cblA type (Disease Ontology:DOID:0060742); methylmalonic acidemia (Disease Ontology:DOID:14749)", "pathway": " (mmu:109136); (R-MMU-71032); (R-MMU-9759218)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;23022071;25428506", "class_list": "", "function": "GTPase, binds and hydrolyzes GTP (By similarity). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (By similarity). Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (By similarity). Plays a dual role as both a protectase and a reactivase for MMUT (By similarity). Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (By similarity). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (By similarity)., [UniProtKB, UniProtKB]; The mouse methylmalonic aciduria- related genes, Mmaa, Mmab, and Mut may have specialized functions depending on the tissue or cell type., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2N3;Q8VC22", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;5.4.99.2;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009235 cobalamin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C7H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSU7-1", "uniprot_id": "MOB3A_MOUSE", "mass": 25552.0, "length": 217, "protein_name": "MOB kinase activator 3A", "gene_name": "Mob3a", "organism": "Mouse", "refseq_name": "MOB kinase activator 3A", "refseq_ac": "NP_766045", "gene_names_uniprotkb": "Mob3a; Mobkl2a", "gene_names_refseq": "5330417K06Rik; A630029F06; Mob3a; Mobkl2a", "protein_names_uniprotkb": "MOB kinase activator 3A; Mob1 homolog 2A; Mps one binder kinase activator-like 2A", "protein_names_refseq": "MOB kinase activator 3A; MOB1, Mps One Binder kinase activator-like 2A; mob1 homolog 2A; mps one binder kinase activator-like 2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:208228)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;30084848;34428180", "class_list": "", "function": "May regulate the activity of kinases., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBK2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BSU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H5Y3-1", "uniprot_id": "METH_MOUSE", "mass": 139069.0, "length": 1253, "protein_name": "Methionine synthase", "gene_name": "Mtr", "organism": "Mouse", "refseq_name": "methionine synthase", "refseq_ac": "NP_001074597", "gene_names_uniprotkb": "Mtr", "gene_names_refseq": "D830038K18Rik; MS; Mtr", "protein_names_uniprotkb": "Methionine synthase; 2.1.1.13; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; MS; Vitamin-B12 dependent methionine synthase", "protein_names_refseq": "cobalamin-dependent methionine synthase; methionine synthase; vitamin-B12 dependent methionine synthase", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); vitamin B12 deficiency (Disease Ontology:DOID:0050731); methylmalonic aciduria and homocystinuria type cblG (Disease Ontology:DOID:0050733); spina bifida (Disease Ontology:DOID:0080016); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); autistic disorder (Disease Ontology:DOID:12849); pancreatic cancer (Disease Ontology:DOID:1793); IgA glomerulonephritis (Disease Ontology:DOID:2986); cerebral infarction (Disease Ontology:DOID:3526); retinoblastoma (Disease Ontology:DOID:768); abdominal aortic aneurysm (Disease Ontology:DOID:7693); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:238505); (R-MMU-156581); (R-MMU-1614635); (R-MMU-9013407); (R-MMU-9759218)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180;37174668", "class_list": "", "function": "Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine., [UniProtKB, UniProtKB]; Cognitive Impairment Is Associated with AMPAR Glutamatergic Dysfunction in a Mouse Model of Neuronal Methionine Synthase Deficiency. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 17, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQP2", "ec_number_list": "2.1.1.13;2.7.11.1;3.6.5.-;2.7.10.2;2.7.10.4;3.6.5.2;2.3.1.168;2.7.11.39;3.6.4.6;1.16.1.8;1.16.1.6;2.5.1.151", "go_molecular_function": "GO:0008705 methionine synthase activity;GO:0008270 zinc ion binding;GO:0016597 amino acid binding;GO:0008168 methyltransferase activity;GO:0005542 folic acid binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009235 cobalamin metabolic process;GO:0006479 protein methylation;GO:0048678 response to axon injury;GO:0071732 cellular response to nitric oxide;GO:0031103 axon regeneration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A6H5Y3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AEY4-1", "uniprot_id": "MA7D3_MOUSE", "mass": 98230.0, "length": 876, "protein_name": "MAP7 domain-containing protein 3", "gene_name": "Map7d3", "organism": "Mouse", "refseq_name": "MAP7 domain-containing protein 3", "refseq_ac": "NP_796267", "gene_names_uniprotkb": "Map7d3; Mdp3; Mtap7d3", "gene_names_refseq": "4933424A10Rik; Map7d3; Mtap7d3", "protein_names_uniprotkb": "MAP7 domain-containing protein 3", "protein_names_refseq": "MAP7 domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:320923)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22142902;32376790", "class_list": "", "function": "Human X chromosome exome sequencing identifies BCORL1 as contributor to spermatogenesis., [RefSeq, PubMed]; Promotes the assembly and stability of microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VF65;Q8C7V9;Q8C857;Q8CDD4", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005819 spindle;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2AEY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2BDX3-1", "uniprot_id": "MOCS3_MOUSE", "mass": 49375.0, "length": 460, "protein_name": "Adenylyltransferase and sulfurtransferase MOCS3", "gene_name": "Mocs3", "organism": "Mouse", "refseq_name": "adenylyltransferase and sulfurtransferase MOCS3", "refseq_ac": "NP_001153802", "gene_names_uniprotkb": "Mocs3; Uba4", "gene_names_refseq": "1700020H17Rik; Mocs3; Uba4", "protein_names_uniprotkb": "Adenylyltransferase and sulfurtransferase MOCS3; Adenylyltransferase MOCS3; Molybdenum cofactor synthesis protein 3; Sulfur carrier protein MOCS2A adenylyltransferase; Sulfur carrier protein MOCS2A sulfurtransferase; Sulfurtransferase MOCS3", "protein_names_refseq": "MPT synthase sulfurylase; adenylyltransferase and sulfurtransferase MOCS3", "tax_id": 10090, "disease": "", "pathway": " (mmu:69372); (R-MMU-947581)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25428506;34428180", "class_list": "", "function": "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 acting as a sulfur donor for thiocarboxylation reactions., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.80;2.8.1.11", "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity;GO:0004792 thiosulfate-cyanide sulfurtransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0002098 tRNA wobble uridine modification;GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032324 molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2BDX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H684-1", "uniprot_id": "MGT4E_MOUSE", "mass": 49986.0, "length": 439, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E", "gene_name": "Mgat4e", "organism": "Mouse", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E isoform 1", "refseq_ac": "NP_001138772", "gene_names_uniprotkb": "Mgat4e", "gene_names_refseq": "4931440L10Rik; Mgat4e", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E; 2.4.1.-", "protein_names_refseq": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E isoform 1; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E", "tax_id": 10090, "disease": "", "pathway": " (mmu:71001)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase-like protein that may participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNB9;E9Q5L0;Q8C1J0", "ec_number_list": "", "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6H684-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H6E2-1", "uniprot_id": "MMRN2_MOUSE", "mass": 105206.0, "length": 943, "protein_name": "Multimerin-2", "gene_name": "Mmrn2", "organism": "Mouse", "refseq_name": "multimerin-2 precursor", "refseq_ac": "NP_694767", "gene_names_uniprotkb": "Mmrn2", "gene_names_refseq": "ENDOGLYX1; Emilin3; EndoGlyx-1; Mmrn2", "protein_names_uniprotkb": "Multimerin-2", "protein_names_refseq": "Multimerin-2; elastin microfibril interfacer 3; multimerin-2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:105450); (R-MMU-5173105)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17988845;21750661;30899004;31422156;32291340;34418053;34428180", "class_list": "", "function": "Extracellular matrix protein that plays significant roles in the vascular system and is required for the maintenance and stability of blood vessel. Affects several essential steps in angiogenesis including endothelial cell proliferation, migration, and tube formation. Positively regulates angiogenesis by acting as a ligand for CD93 receptor., [UniProtKB, UniProtKB]; Mmrn2 interacts with anthrax protective antigen., [RefSeq, PubMed]; Multimerin-2 maintains vascular stability and permeability., [RefSeq, PubMed]; These results reveal that CD93 is a negative regulator of the onset of astrogenesis and provide insight into therapy for psychiatric disorders., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 6, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJX4;Q8K1Z7", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "A6H6E2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78IK4-1", "uniprot_id": "MIC27_MOUSE", "mass": 29261.0, "length": 265, "protein_name": "MICOS complex subunit Mic27", "gene_name": "Apool", "organism": "Mouse", "refseq_name": "MICOS complex subunit Mic27 isoform 1 precursor", "refseq_ac": "NP_080841", "gene_names_uniprotkb": "Apool; Fam121a; Mic27", "gene_names_refseq": "6720473G16Rik; 9430083G14Rik; Apool; E130106L15Rik; Micos27", "protein_names_uniprotkb": "MICOS complex subunit Mic27; Apolipoprotein O-like; Protein FAM121A", "protein_names_refseq": "MICOS complex subunit Mic27 isoform 1 precursor; MICOS complex subunit Mic27", "tax_id": 10090, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (mmu:68117); (R-MMU-114608)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;36288343;37453647;37507081;39927985", "class_list": "glycogene", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0061617 MICOS complex", "go_biological_process": "GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q78IK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKD9-1", "uniprot_id": "MFA1B_MOUSE", "mass": 51954.0, "length": 439, "protein_name": "Microfibrillar-associated protein 1B", "gene_name": "Mfap1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mfap1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Microfibrillar-associated protein 1B; Spliceosome B complex protein MFAP1B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:100034361); (mmu:67532); (R-MMU-72163)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15345747;17242355;19131326;19144319;21183079;25428506;30779550", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU29;Q8CCL1;Q9CQU1;Q9CSJ5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0031012 extracellular matrix;GO:0001527 microfibril", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "C0HKD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1C6-1", "uniprot_id": "MET22_MOUSE", "mass": 43586.0, "length": 393, "protein_name": "Methyltransferase-like protein 22", "gene_name": "Mettl22", "organism": "Mouse", "refseq_name": "methyltransferase-like protein 22 isoform 1", "refseq_ac": "NP_666359", "gene_names_uniprotkb": "Mettl22", "gene_names_refseq": "Mettl22", "protein_names_uniprotkb": "Methyltransferase-like protein 22; 2.1.1.-", "protein_names_refseq": "methyltransferase like 22; methyltransferase-like protein 22 isoform 1; methyltransferase-like protein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:239706); (R-MMU-8876725)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Protein N-lysine methyltransferase. Trimethylates KIN at Lys-135 (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UW48", "ec_number_list": "2.1.1.-;2.1.1.359;2.1.1.372", "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0008276 protein methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006479 protein methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R1C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZV4-1", "uniprot_id": "MOGT1_MOUSE", "mass": 38791.0, "length": 335, "protein_name": "2-acylglycerol O-acyltransferase 1", "gene_name": "Mogat1", "organism": "Mouse", "refseq_name": "2-acylglycerol O-acyltransferase 1", "refseq_ac": "NP_080989", "gene_names_uniprotkb": "Mogat1; Dgat2l1", "gene_names_refseq": "0610030A14Rik; 1110064N14Rik; Dgat2l1; Dgat2l; MGAT1; Mogat1; WI1-2612I11.1; mDC2", "protein_names_uniprotkb": "2-acylglycerol O-acyltransferase 1; 2.3.1.22; Acyl-CoA:monoacylglycerol acyltransferase 1; Diacylglycerol acyltransferase 2-like protein 1; MGAT1; Monoacylglycerol O-acyltransferase 1", "protein_names_refseq": "2-acylglycerol O-acyltransferase 1; acyl-CoA:monoacylglycerol acyltransferase 1; diacylglycerol O-acyltransferase 2-like 1; diacylglycerol acyltransferase 2-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68393); (R-MMU-75109)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11481335;12077311;12621063;16106050;21750661;24595352;26880786;33676028;36321276;38061546", "class_list": "", "function": "A minimal role, if any, of MOGAT1 in liver TAG synthesis, [RefSeq, PubMed]; Exercise intensity impacts the improvement of metabolic dysfunction-associated steatotic liver disease via variations of monoacylglycerol O-acyltransferase 1 expression., [RefSeq, PubMed]; Inactivation of hepatic MGAT activity, which is markedly increased in obese mice, improved glucose tolerance and hepatic insulin signaling independent of changes in body weight, intrahepatic DAG and TAG content, and PKC signaling., [RefSeq, PubMed]; Involved in glycerolipid synthesis and lipid metabolism (PubMed:12077311, PubMed:12621063). Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol, mainly at the sn-1 or sn-3 positions (PubMed:12077311, PubMed:12621063). It uses both sn-2-monoacylglycerol (2-acylglycerol) and sn-1-monoacylglycerol (1-acyl-sn-glycerol) equally well as substrates, and uses sn-3-monoacylglycerol (3-acyl-sn-glycerol) with lower efficiency (PubMed:12077311). Probably not involved in absorption of dietary fat in the small intestine., [UniProtKB, PubMed, PubMed]; MGAT1 identified, biochemical characteristics and tissue distribution reported., [RefSeq, PubMed]; Monoacylglycerol O-acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice., [RefSeq, PubMed]; Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLA2;Q9DCL0", "ec_number_list": "2.3.1.75;2.3.1.20;2.3.1.76;2.3.1.22;2.3.1.-;2.3.1.62", "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006651 diacylglycerol biosynthetic process;GO:0019432 triglyceride biosynthetic process;GO:0006071 glycerol metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91ZV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U481-1", "uniprot_id": "MFS12_MOUSE", "mass": 51504.0, "length": 476, "protein_name": "Major facilitator superfamily domain-containing protein 12", "gene_name": "Mfsd12", "organism": "Mouse", "refseq_name": "major facilitator superfamily domain-containing protein 12", "refseq_ac": "NP_082933", "gene_names_uniprotkb": "Mfsd12; F630110N24Rik", "gene_names_refseq": "C19orf28; F630110N24Rik; Mfsd12; Wdt1; gr", "protein_names_uniprotkb": "Major facilitator superfamily domain-containing protein 12; Protein grizzled", "protein_names_refseq": "major facilitator superfamily domain-containing protein 12; protein grizzled", "tax_id": 10090, "disease": "", "pathway": " (mmu:73822)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19144319;21750661;29025994;31219806;33208952;37874775", "class_list": "", "function": "The MFSD12 p.Tyr182His common variant is sufficient to alter mouse agouti coat color., [RefSeq, PubMed]; Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin/hair pigmentation (PubMed:33208952). In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin/hair pigmentation (PubMed:33208952). Also catalyzes import of cysteine into lysosomes in non-pigmented cells, regulating lysosomal cystine and cysteine storage, which is essential for redox homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U376", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0033229 cysteine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0042470 melanosome;GO:0005770 late endosome", "go_biological_process": "GO:0048022 negative regulation of melanin biosynthetic process;GO:0008643 carbohydrate transport;GO:0042438 melanin biosynthetic process;GO:1903712 cysteine transmembrane transport;GO:0048021 regulation of melanin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3U481-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQE6-1", "uniprot_id": "MACOI_MOUSE", "mass": 76089.0, "length": 664, "protein_name": "Macoilin", "gene_name": "Maco1", "organism": "Mouse", "refseq_name": "macoilin isoform 1", "refseq_ac": "NP_079658", "gene_names_uniprotkb": "Maco1; Tmem57", "gene_names_refseq": "1110007C24Rik; 9230118A01Rik; C61; Maco1; Tmem57", "protein_names_uniprotkb": "Macoilin; Brain-specific adapter protein C61; Macoilin-1; Transmembrane protein 57", "protein_names_refseq": "brain-specific adapter protein C61; brain-specific adaptor protein C61; macoilin isoform 1; macoilin; transmembrane protein 57", "tax_id": 10090, "disease": "", "pathway": " (mmu:66146); (R-MMU-8980692); (R-MMU-9013106)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15255972;17242355;21183079;21750661;34428180;36852467;40885482", "class_list": "", "function": "From E14.5 to birth, C61 was highly expressed in all neuronal differentiation fields, with the highest signal in the telencephalic cortical plate and mitral cells in the olfactory bulb., [RefSeq, PubMed]; Plays a role in the regulation of neuronal activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030424 axon;GO:0031965 nuclear membrane;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0023041 neuronal signal transduction;GO:0006935 chemotaxis;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7TQE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U2U7-1", "uniprot_id": "MET17_MOUSE", "mass": 52061.0, "length": 461, "protein_name": "Ribosome assembly protein METTL17, mitochondrial", "gene_name": "Mettl17", "organism": "Mouse", "refseq_name": "ribosome assembly protein METTL17, mitochondrial precursor", "refseq_ac": "NP_001025161", "gene_names_uniprotkb": "Mettl17; D14Ertd209e", "gene_names_refseq": "2310032K15Rik; D14Ertd209e; Mett11d1; Mettl17", "protein_names_uniprotkb": "Ribosome assembly protein METTL17, mitochondrial; Methyltransferase-like protein 17", "protein_names_refseq": "methyltransferase 11 domain containing 1; methyltransferase 11 domain-containing protein 1; methyltransferase-like protein 17, mitochondrial; protein RSM22 homolog, mitochondrial; ribosome assembly protein METTL17, mitochondrial precursor; ribosome assembly protein METTL17, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:52535)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31487196", "class_list": "", "function": "Mitochondrial ribosome (mitoribosome) assembly factor (PubMed:31487196). Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body (By similarity). Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSP2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0008168 methyltransferase activity;GO:0097177 mitochondrial ribosome binding;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006412 translation;GO:0042274 ribosomal small subunit biogenesis;GO:0180026 mitochondrial small ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U2U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC42-1", "uniprot_id": "RMC1_MOUSE", "mass": 74922.0, "length": 657, "protein_name": "Regulator of MON1-CCZ1 complex", "gene_name": "Rmc1", "organism": "Mouse", "refseq_name": "regulator of MON1-CCZ1 complex", "refseq_ac": "NP_083899", "gene_names_uniprotkb": "Rmc1; Mic1; Wdr98", "gene_names_refseq": "2400010D15Rik; 3110002H16Rik; Mic-1; Mic1; Rmc1; Wdr98", "protein_names_uniprotkb": "Regulator of MON1-CCZ1 complex; Colon cancer-associated protein Mic1; Mic-1", "protein_names_refseq": "colon cancer-associated protein Mic1 homolog; regulator of MON1-CCZ1 complex; uncharacterized protein C18orf8 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76482)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;37507081;9211850", "class_list": "", "function": "Component of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35606", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005770 late endosome;GO:0035658 Mon1-Ccz1 complex", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VC42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80V70-1", "uniprot_id": "MEGF6_MOUSE", "mass": 164723.0, "length": 1572, "protein_name": "Multiple epidermal growth factor-like domains protein 6", "gene_name": "Megf6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Megf6; Egfl3", "gene_names_refseq": "", "protein_names_uniprotkb": "Multiple epidermal growth factor-like domains protein 6; EGF-like protein 3; Epidermal growth factor-like protein 3; Multiple EGF-like domains protein 6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:230971)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2A913", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80V70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q812F8-1", "uniprot_id": "MGT4B_MOUSE", "mass": 63302.0, "length": 548, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B", "gene_name": "Mgat4b", "organism": "Mouse", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B", "refseq_ac": "NP_666038", "gene_names_uniprotkb": "Mgat4b", "gene_names_refseq": "GnTIVb; Mgat4b", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; 2.4.1.145; GlcNAc-T IVb; GnT-IVb; N-acetylglucosaminyltransferase IVb; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb", "protein_names_refseq": "GlcNAc-T IVb; N-acetylglucosaminyltransferase IVb; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; gnT-IVb; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B", "tax_id": 10090, "disease": "", "pathway": " (mmu:103534); (R-MMU-975577)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10372966;21750661;30084848;31219806;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that catalyzes the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains. Prefers complex-type N-glycans over hybrid-types. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2D9;Q812F9;Q8R0L4", "ec_number_list": "2.4.1.145", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity;GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005795 Golgi stack;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 3884, "hit_score": 1.1, "record_id": "Q812F8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH27-1", "uniprot_id": "MEGF9_MOUSE", "mass": 62831.0, "length": 600, "protein_name": "Multiple epidermal growth factor-like domains protein 9", "gene_name": "Megf9", "organism": "Mouse", "refseq_name": "multiple epidermal growth factor-like domains protein 9 precursor", "refseq_ac": "NP_766282", "gene_names_uniprotkb": "Megf9; Egfl5; Kiaa0818", "gene_names_refseq": "4933405H16Rik; 9630025C07; Egfl5; Megf9; mKIAA0818", "protein_names_uniprotkb": "Multiple epidermal growth factor-like domains protein 9; EGF-like protein 5; Epidermal growth factor-like protein 5; Multiple EGF-like domains protein 9", "protein_names_refseq": "EGF-like protein 5; EGF-like-domain, multiple 5; epidermal growth factor-like protein 5; multiple EGF-like domains protein 9; multiple epidermal growth factor-like domains protein 9 precursor; multiple epidermal growth factor-like domains protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:230316)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16981854;21750661;30899004;35820727", "class_list": "", "function": "MEGF9 represents a novel putative receptor, expressed in neuronal and non-neuronal tissues, that is regulated during development and could function as a guidance or signalling molecule., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 6, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWI4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0005604 basement membrane;GO:0043256 laminin complex", "go_biological_process": "GO:0016477 cell migration;GO:0009887 animal organ morphogenesis;GO:0034446 substrate adhesion-dependent cell spreading;GO:0007411 axon guidance;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BH27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXH8-1", "uniprot_id": "MET25_MOUSE", "mass": 66736.0, "length": 597, "protein_name": "Probable methyltransferase-like protein 25", "gene_name": "Mettl25", "organism": "Mouse", "refseq_name": "probable methyltransferase-like protein 25 isoform 1", "refseq_ac": "NP_997405", "gene_names_uniprotkb": "Mettl25; BC067068", "gene_names_refseq": "Mettl25", "protein_names_uniprotkb": "Probable methyltransferase-like protein 25; 2.1.1.-", "protein_names_refseq": "methyltransferase-like protein 25; probable methyltransferase-like protein 25 isoform 1; probable methyltransferase-like protein 25", "tax_id": 10090, "disease": "", "pathway": " (mmu:216292)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Probable methyltransferase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMX5", "ec_number_list": "", "go_molecular_function": "GO:0008168 methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NXH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6XJV4-1", "uniprot_id": "MO2R4_MOUSE", "mass": 29625.0, "length": 270, "protein_name": "Cell surface glycoprotein CD200 receptor 4", "gene_name": "Cd200r4", "organism": "Mouse", "refseq_name": "cell surface glycoprotein CD200 receptor 4 precursor", "refseq_ac": "NP_997127", "gene_names_uniprotkb": "Cd200r4", "gene_names_refseq": "Cd200r4; F630107N04Rik; MCD200RLa", "protein_names_uniprotkb": "Cell surface glycoprotein CD200 receptor 4; CD200 cell surface glycoprotein receptor-like 4; CD200 cell surface glycoprotein receptor-like a; CD200 receptor-like 4; CD200RLa; Cell surface glycoprotein OX2 receptor 4", "protein_names_refseq": "CD200 cell surface glycoprotein receptor-like 4; CD200 cell surface glycoprotein receptor-like a; CD200 cell surface glycoprotein receptor; CD200 receptor-like 4; CD200RLa; cell surface glycoprotein CD200 receptor 4 precursor; cell surface glycoprotein CD200 receptor 4; cell surface glycoprotein OX2 receptor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:239849)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12960329;15187158;15274657;15471863;16081818;21750661;23602662", "class_list": "", "function": "Involved in the recruitment or surface expression of the TYROBP receptor., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0150077 regulation of neuroinflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6XJV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08911-1", "uniprot_id": "MK12_MOUSE", "mass": 42043.0, "length": 367, "protein_name": "Mitogen-activated protein kinase 12", "gene_name": "Mapk12", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 12 isoform 1", "refseq_ac": "NP_038899", "gene_names_uniprotkb": "Mapk12; Sapk3", "gene_names_refseq": "Erk6; Mapk12; P38gamma; Prkm12; Sapk3", "protein_names_uniprotkb": "Mitogen-activated protein kinase 12; 2.7.11.24; ERK-6; Extracellular signal-regulated kinase 6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; Mitogen-activated protein kinase p38 gamma; Stress-activated protein kinase 3", "protein_names_refseq": "ERK-6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; extracellular signal-regulated kinase 6; mitogen-activated protein kinase 12 isoform 1; mitogen-activated protein kinase p38 gamma; stress-activated protein kinase 3", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:29857); (R-MMU-168638); (R-MMU-4420097); (R-MMU-525793); (R-MMU-5675221)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "11991731;20004242;20026657;20626350;21170151;21183079;21558321;36766738;37458356;39927985", "class_list": "", "function": "Cardiac expression and subcellular localization, [RefSeq, PubMed]; Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats. Publication Status: Online-Only, [RefSeq, PubMed]; P38gamma and p38delta modulate innate immune response by regulating MEF2D activation. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0M4", "ec_number_list": "2.7.11.1;3.1.3.48;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.1;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.6.5.2;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0000165 MAPK cascade;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O08911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54732-1", "uniprot_id": "MMP15_MOUSE", "mass": 74666.0, "length": 657, "protein_name": "Matrix metalloproteinase-15", "gene_name": "Mmp15", "organism": "Mouse", "refseq_name": "matrix metalloproteinase-15 preproprotein", "refseq_ac": "NP_032635", "gene_names_uniprotkb": "Mmp15", "gene_names_refseq": "MT-MMP 2; MT2-MMP; Mmp15", "protein_names_uniprotkb": "Matrix metalloproteinase-15; 3.4.24.-; MMP-15; MT-MMP 2; MT2-MMP; MT2MMP; MTMMP2; Membrane-type matrix metalloproteinase 2; Membrane-type-2 matrix metalloproteinase", "protein_names_refseq": "Membrane type 2-MMP; matrix metalloproteinase-15 preproprotein; matrix metalloproteinase-15; membrane-type-2 matrix metalloproteinase", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); transitional cell carcinoma (Disease Ontology:DOID:2671)", "pathway": " (mmu:17388); (R-MMU-1442490); (R-MMU-1592389)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;30084848;34428180;9037199", "class_list": "", "function": "Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A., [UniProtKB]; This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. A deficiency of the encoded protein in mice is compatible with normal development and postnatal growth. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.-;3.4.21.75;3.4.24.80", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0032355 response to estradiol;GO:0030574 collagen catabolic process;GO:0035987 endodermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54732-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54790-1", "uniprot_id": "MAFG_MOUSE", "mass": 17877.0, "length": 162, "protein_name": "Transcription factor MafG", "gene_name": "Mafg", "organism": "Mouse", "refseq_name": "transcription factor MafG", "refseq_ac": "NP_034886", "gene_names_uniprotkb": "Mafg", "gene_names_refseq": "C630022N07Rik; Mafg", "protein_names_uniprotkb": "Transcription factor MafG; V-maf musculoaponeurotic fibrosarcoma oncogene homolog G", "protein_names_refseq": "V-maf musculoaponeurotic fibrosarcoma oncogene homolog G; avian musculoaponeurotic fibrosarcoma virus (v-maf) AS42 oncogene, protein G; transcription factor MafG; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G", "tax_id": 10090, "disease": "", "pathway": " (mmu:17134); (R-MMU-983231)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11875518;16738329;29138682;31383749;31398338;32005828;38977234;9679061", "class_list": "", "function": "In condition of hypoxia, MAFG induction correlated with reduced levels of miR-128. This lead to increased mRNA levels of HMOX-1 and x-CT for blunting stress. Overall, these findings identify MAFG as novel direct target of miR-128., [RefSeq, PubMed]; Inhibition of HMOX1 by MAFG potentiates the development of depression-like behavior in mice associated with astrocyte-mediated neuroinflammation., [RefSeq, PubMed]; Results provide direct evidence that the Nrf2-MafG heterodimer acts as a transcriptional activator of Nrf2-dependent genes Publication Status: Online-Only, [RefSeq, PubMed]; Silencing Mafg in mouse hepatocytes and obese mice elicits a fasting-like gene expression profile, improves glucose metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:16738329, PubMed:9679061). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:16738329, PubMed:9679061). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin gene expression when associated with NFE2L2 (By similarity). May be involved in signal transduction of extracellular H(+) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0045604 regulation of epidermal cell differentiation;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54790-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C7A3-1", "uniprot_id": "MBOA4_MOUSE", "mass": 49879.0, "length": 435, "protein_name": "Membrane-bound ghrelin O-acyltransferase MBOAT4", "gene_name": "Mboat4", "organism": "Mouse", "refseq_name": "membrane-bound ghrelin O-acyltransferase MBOAT4 isoform 1", "refseq_ac": "NP_001119786", "gene_names_uniprotkb": "Mboat4; Gm171; Goat", "gene_names_refseq": "GOAT; Gm171; Mboat4", "protein_names_uniprotkb": "Membrane-bound ghrelin O-acyltransferase MBOAT4; 2.3.1.-; Membrane-bound O-acyltransferase domain-containing protein 4; O-acyltransferase domain-containing protein 4", "protein_names_refseq": "O-acyltransferase domain-containing protein 4; ghrelin O-acyltransferase; membrane-bound O-acyltransferase domain-containing protein 4; membrane-bound ghrelin O-acyltransferase MBOAT4 isoform 1; membrane-bound ghrelin O-acyltransferase MBOAT4", "tax_id": 10090, "disease": "", "pathway": " (mmu:234155); (R-MMU-422085)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "18267071;18443287;18669668;19401456;19479831;19501572;24045953;28134508;33103129;34946685;35180934", "class_list": "", "function": "Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (PubMed:18267071, PubMed:18443287, PubMed:18669668, PubMed:19501572, PubMed:24045953, PubMed:28134508). In vitro also uses acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient (PubMed:19501572)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GOAT is the only member of the MBOAT family whose expression is highly enriched within gastric ghrelin cells and whose whole body distribution mirrors that of ghrelin., [RefSeq, PubMed]; GOAT mRNA was expressed in murine cartilage explants as well as in the cultured murine chondrogenic ATDC-5 cell line., [RefSeq, PubMed]; Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus., [RefSeq, PubMed]; In Search of Small Molecules That Selectively Inhibit MBOAT4. Publication Status: Online-Only, [RefSeq, PubMed]; Inactive octanoyltransferase activity., [UniProtKB, PubMed]; Study identifies GOAT (Ghrelin O-Acyltransferase), a polytopic membrane-bound enzyme that attaches octanoate to serine-3 of ghrelin; consistent with its function, GOAT mRNA is restricted to stomach and intestine, the ghrelin-secreting tissues., [RefSeq, PubMed]; The identification and characterization of human GOAT, the ghrelin O-acyl transferase, is reported., [RefSeq, PubMed]; Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1Q004;B2RWL6", "ec_number_list": "2.3.1.-;2.7.1.91", "go_molecular_function": "GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0016412 serine O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0018191 peptidyl-serine octanoylation;GO:0030258 lipid modification;GO:0018190 protein octanoylation;GO:0043543 protein acylation;GO:0051366 protein decanoylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P0C7A3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26187-1", "uniprot_id": "MGMT_MOUSE", "mass": 22435.0, "length": 211, "protein_name": "Methylated-DNA--protein-cysteine methyltransferase", "gene_name": "Mgmt", "organism": "Mouse", "refseq_name": "methylated-DNA--protein-cysteine methyltransferase isoform 1", "refseq_ac": "NP_032624", "gene_names_uniprotkb": "Mgmt", "gene_names_refseq": "AGT; Agat; Mgmt", "protein_names_uniprotkb": "Methylated-DNA--protein-cysteine methyltransferase; 2.1.1.63; 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase", "protein_names_refseq": "6-O-methylguanine-DNA methyltransferase; O-6-alkylguanine-DNA alkyltransferase; O-6-methylguanine-DNA-alkyltransferase; methylated-DNA--protein-cysteine methyltransferase isoform 1; methylated-DNA--protein-cysteine methyltransferase", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic endocrine carcinoma (Disease Ontology:DOID:1798); melanoma (Disease Ontology:DOID:1909); colon adenocarcinoma (Disease Ontology:DOID:234); cervix carcinoma (Disease Ontology:DOID:2893); granulosa cell tumor (Disease Ontology:DOID:2999); glioblastoma (Disease Ontology:DOID:3068); oligodendroglioma (Disease Ontology:DOID:3181); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cholangiocarcinoma (Disease Ontology:DOID:4947); gastrinoma (Disease Ontology:DOID:5577); retinoblastoma (Disease Ontology:DOID:768)", "pathway": " (mmu:17314)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1371399;31951021;34428180;35820727;36210013;38277015", "class_list": "", "function": "Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma., [RefSeq, PubMed]; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated., [UniProtKB]; Magnetic resonance imaging reveals specific anatomical changes in the brain of Agat- and Gamt-mice attributed to creatine depletion and guanidinoacetate alteration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q54A49", "ec_number_list": "2.1.1.63", "go_molecular_function": "GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity;GO:0003677 DNA binding;GO:0005509 calcium ion binding;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0043066 negative regulation of apoptotic process;GO:0006307 DNA alkylation repair;GO:0006974 DNA damage response;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P26187-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51180-1", "uniprot_id": "MIP_MOUSE", "mass": 28193.0, "length": 263, "protein_name": "Lens fiber major intrinsic protein", "gene_name": "Mip", "organism": "Mouse", "refseq_name": "lens fiber major intrinsic protein", "refseq_ac": "NP_032626", "gene_names_uniprotkb": "Mip; Palm", "gene_names_refseq": "Aqp0; Cat; Cts; Hfi; Lop; MIP26; MP26; Mip; Svl; shrivelled", "protein_names_uniprotkb": "Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26", "protein_names_refseq": "aquaporin-0; cataract and small eye; dominant cataract; hydropic fibers; lens fiber major intrinsic protein; lens opacity; major intrinsic protein of eye lens fiber", "tax_id": 10090, "disease": "cataract 15 multiple types (Disease Ontology:DOID:0110251); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:17339); (R-MMU-432047)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22095752;23734214;25428506;8563764", "class_list": "", "function": "Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Specifically expressed in lens fiber cells, this aquaporin is crucial for maintaining lens water homeostasis and transparency. Beyond water permeability, it also acts as a cell-to-cell adhesion molecule, forming thin junctions between lens fiber cells that are essential for maintaining the ordered structure and transparency of the lens., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O00285;Q3UWJ9;Q8BHA2", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0015267 channel activity;GO:0015250 water channel activity;GO:0005212 structural constituent of eye lens;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0046691 intracellular canaliculus;GO:0070161 anchoring junction", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0015722 canalicular bile acid transport;GO:0007601 visual perception;GO:0007154 cell communication;GO:0006833 water transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60882-1", "uniprot_id": "MEGF8_MOUSE", "mass": 297487.0, "length": 2789, "protein_name": "Multiple epidermal growth factor-like domains protein 8", "gene_name": "Megf8", "organism": "Mouse", "refseq_name": "multiple epidermal growth factor-like domains protein 8 precursor", "refseq_ac": "NP_001153872", "gene_names_uniprotkb": "Megf8; Egfl4", "gene_names_refseq": "Egfl4; Megf8; b2b1702.2Clo; b2b1702Clo; b2b288Clo; m687Ddg; mKIAA0817", "protein_names_uniprotkb": "Multiple epidermal growth factor-like domains protein 8; EGF-like protein 4; Epidermal growth factor-like protein 4; Multiple EGF-like domains protein 8", "protein_names_refseq": "EGF-like protein 4; EGF-like-domain, multiple 4; epidermal growth factor-like protein 4; multiple EGF-like domains protein 8; multiple epidermal growth factor-like domains protein 8 precursor; multiple epidermal growth factor-like domains protein 8", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Carpenter syndrome (Disease Ontology:DOID:0060234); Carpenter syndrome 2 (Disease Ontology:DOID:0061099)", "pathway": " (mmu:269878)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;18821597;24052814;25428506;29290584;30899004;31219806;32203821;33300544;34428180", "class_list": "", "function": "Acts as a negative regulator of hedgehog signaling (PubMed:29290584)., [UniProtKB, PubMed]; Megf8 attenuates signaling through the Hedgehog pathway by reducing levels of Smoothened at the cell surface and the primary cilium. Mutations in Megf8 lead to cardiac defects, limb defects, left-right patterning defects and craniofacial anomalies. Erratum:[Dev Cell. 2018 Jan 22;44(2):271. doi: 10.1016/j.devcel.2018.01.002. PMID: 29401421], [RefSeq, PubMed]; Megf8 is involved in mediating BMP4 signaling and guidance of developing trigeminal ganglia axons. Publication Status: Online-Only, [RefSeq, PubMed]; Spatial and temporal deletion reveals a latent effect of Megf8 on the left-right patterning and heart development., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 13, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 3, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "B3GR00;Q80TR3;Q80V41;Q8BMN9;Q8JZW7;Q8K0J3", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0060972 left/right pattern formation;GO:0097094 craniofacial suture morphogenesis;GO:0001701 in utero embryonic development;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P60882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97309-1", "uniprot_id": "MESP1_MOUSE", "mass": 26386.0, "length": 243, "protein_name": "Mesoderm posterior protein 1", "gene_name": "Mesp1", "organism": "Mouse", "refseq_name": "mesoderm posterior protein 1", "refseq_ac": "NP_032614", "gene_names_uniprotkb": "Mesp1", "gene_names_refseq": "Mesp1; bHLHc5", "protein_names_uniprotkb": "Mesoderm posterior protein 1", "protein_names_refseq": "mesoderm posterior protein 1", "tax_id": 10090, "disease": "myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:17292)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10887078;15677726;17306789;8787751", "class_list": "", "function": "Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q059W2", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0060913 cardiac cell fate determination;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97309-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05A36-1", "uniprot_id": "MEX3C_MOUSE", "mass": 68574.0, "length": 652, "protein_name": "RNA-binding E3 ubiquitin-protein ligase MEX3C", "gene_name": "Mex3c", "organism": "Mouse", "refseq_name": "RNA-binding E3 ubiquitin-protein ligase MEX3C", "refseq_ac": "NP_001034303", "gene_names_uniprotkb": "Mex3c; Rkhd2", "gene_names_refseq": "A130001D14Rik; BM-013; Mex3c; Rkhd2", "protein_names_uniprotkb": "RNA-binding E3 ubiquitin-protein ligase MEX3C; 2.3.2.27; RING finger and KH domain-containing protein 2; RING-type E3 ubiquitin transferase MEX3C", "protein_names_refseq": "RING finger and KH domain-containing protein 2; RING-type E3 ubiquitin transferase MEX3C; RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein MEX3C; mex3 homolog C; ring finger and KH domain containing 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:240396); (R-MMU-983168)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "22357625;22927639;24706898;24741071;28982131;33180120;33191393;37652868", "class_list": "", "function": "Construction of a Mex3c Gene-Deficient Mouse Model to Study C-FOS Expression in Hypothalamic Nuclei and Observe Morphological Differences in Embryonic Neural Tube Development. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that Mex3c mutation significantly increases physical activity., [RefSeq, PubMed]; Data suggest that MEX3C plays an important role in enhancing the translation of Igf1 mRNA directly or indirectly and promoting postnatal growth, [RefSeq, PubMed]; MEX3C associates with the endolysosomal compartment through an endocytosis-like process. siRNA-mediated inhibition of the MEX3C or AP-2 complex substantially decreased exosomal but not cellular microRNA miR-451a expression Publication Status: Online-Only, [RefSeq, PubMed]; MEX3C induces cognitive impairment in mice through autophagy inhibition., [RefSeq, PubMed]; MEX3C is required for cytokine production after infection with RNA viruses that are detected by RIG-I., [RefSeq, PubMed]; Mex3c mutation affects lactation through impairing milk ejection in female mice., [RefSeq, PubMed]; Mex3c mutation caused leanness in both heterozygous and homozygous transgenic mice, as well as a more beneficial blood glucose and lipid profile in homozygous transgenic mice, in both sexes; data show Mex3c is involved in energy balance regulation, [RefSeq, PubMed]; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2VPQ2", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0003415 chondrocyte hypertrophy;GO:0097009 energy homeostasis;GO:0045598 regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q05A36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08874-1", "uniprot_id": "MITF_MOUSE", "mass": 58605.0, "length": 526, "protein_name": "Microphthalmia-associated transcription factor", "gene_name": "Mitf", "organism": "Mouse", "refseq_name": "microphthalmia-associated transcription factor isoform 1", "refseq_ac": "NP_001106669", "gene_names_uniprotkb": "Mitf; Bw; Mi; Vit", "gene_names_refseq": "BCC2; Bhlhe32; Gsfbcc2; Mitf; Vitiligo; Wh; bw; mi; vit", "protein_names_uniprotkb": "Microphthalmia-associated transcription factor", "protein_names_refseq": "black eyed white; microphtalmia-associated transcription factor; microphthalmia-associated transcription factor isoform 1; microphthalmia-associated transcription factor", "tax_id": 10090, "disease": "Tietz syndrome (Disease Ontology:DOID:0090002); ocular albinism with sensorineural deafness (Disease Ontology:DOID:0090100); Waardenburg syndrome type 1 (Disease Ontology:DOID:0110948); Waardenburg syndrome type 2A (Disease Ontology:DOID:0110950); osteopetrosis (Disease Ontology:DOID:13533); Tietze's syndrome (Disease Ontology:DOID:14021); melanoma (Disease Ontology:DOID:1909); lysosomal storage disease (Disease Ontology:DOID:3211); Camurati-Engelmann disease (Disease Ontology:DOID:4997); familial melanoma (Disease Ontology:DOID:6846); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (mmu:17342); (R-MMU-3232118); (R-MMU-9824594); (R-MMU-9856649)", "pathway_count": 4, "publication_count": 23, "publication_id_list": "10400990;10790403;14726002;14975237;15572665;17182576;17438132;21183079;21750661;23028343;23207919;25428506;30084848;32848054;34428180;34678516;36852467;40885482;7874168;8343963;8407885;8622664;9647758", "class_list": "", "function": "Data show that there is physiological switching of Mitf isoforms and that the promoter context and the cell context have a combined influence on gene expression programs., [RefSeq, PubMed]; This transcription factor serves at a critical point between extracellular signaling and downstream targets in cell specification in early eye and neural crest development. Mutant alleles have been identified that generate distinct phenotypes. Some of these alleles are being used to model the human diseases Waardenburg syndrome IIa and Tietz syndrome. [provided by RefSeq, Jul 2008]., [RefSeq]; This work defines the transcriptome regulated by Mitf in mast cells and supports its role as master regulator of mast cell differentiation., [RefSeq, PubMed]; Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (By similarity). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (By similarity). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (By similarity). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (By similarity). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A0N4SVJ5;O08885;O88203;Q08843;Q3U2D2;Q60781;Q60782;Q9JIJ0;Q9JIJ1;Q9JIJ2;Q9JIJ3;Q9JIJ4;Q9JIJ5;Q9JIJ6;Q9JKX9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005765 lysosomal membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:2001141 regulation of RNA biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q08874-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08AU7-1", "uniprot_id": "MADL2_MOUSE", "mass": 33165.0, "length": 307, "protein_name": "Myeloid-associated differentiation marker-like protein 2", "gene_name": "Myadml2", "organism": "Mouse", "refseq_name": "myeloid-associated differentiation marker-like protein 2 isoform 2", "refseq_ac": "NP_001191749", "gene_names_uniprotkb": "Myadml2", "gene_names_refseq": "1110012N22Rik; Myadml2", "protein_names_uniprotkb": "Myeloid-associated differentiation marker-like protein 2", "protein_names_refseq": "myeloid-associated differentiation marker-like protein 2 isoform 2; myeloid-associated differentiation marker-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68515)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKP1;Q9D1F1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08AU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0P557-1", "uniprot_id": "MIEAP_MOUSE", "mass": 60398.0, "length": 537, "protein_name": "Mitochondria-eating protein", "gene_name": "Spata18", "organism": "Mouse", "refseq_name": "mitochondria-eating protein", "refseq_ac": "NP_848474", "gene_names_uniprotkb": "Spata18; Mieap", "gene_names_refseq": "1700067I02Rik; Mieap; Spata18", "protein_names_uniprotkb": "Mitochondria-eating protein; Spermatogenesis-associated protein 18", "protein_names_refseq": "mitochondria-eating protein; spermatogenesis associated 18 homolog; spermatogenesis-associated protein 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:73472)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21300779;21750661;26216032;32453416;36187114", "class_list": "", "function": "DNA damage invokes mitophagy through a pathway involving Spata18., [RefSeq, PubMed]; Findings suggest that the Mieap-regulated mitochondrial quality control plays a critical role in preventing mouse intestinal tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Binds cardiolipin. May form molecular condensates (non-membrane-bounded organelles) within mitochondria that compartmentalize and promote cardiolipin metabolism., [UniProtKB, UniProtKB]; MIEAP and ATG5 are tumor suppressors in a mouse model of BRAF(V600E)-positive thyroid cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Show that SPATA18 transcription is induced by p53 in a variety of cell types of both human and mouse origin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZMP4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:1901612 cardiolipin binding;GO:0140693 molecular condensate scaffold activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1900210 positive regulation of cardiolipin metabolic process;GO:0035965 cardiolipin acyl-chain remodeling;GO:0035694 mitochondrial protein catabolic process;GO:0032049 cardiolipin biosynthetic process;GO:0035695 mitophagy by internal vacuole formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q0P557-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14CH1-1", "uniprot_id": "MOCOS_MOUSE", "mass": 95013.0, "length": 862, "protein_name": "Molybdenum cofactor sulfurase", "gene_name": "Mocos", "organism": "Mouse", "refseq_name": "molybdenum cofactor sulfurase", "refseq_ac": "NP_081055", "gene_names_uniprotkb": "Mocos", "gene_names_refseq": "1110018O12Rik; HMCS; MCS; MOS; Mocos", "protein_names_uniprotkb": "Molybdenum cofactor sulfurase; 2.8.1.9; MCS; MOS; MoCo sulfurase; Molybdenum cofactor sulfurtransferase", "protein_names_refseq": "moCo sulfurase; molybdenum cofactor sulfurase; molybdenum cofactor sulfurtransferase", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); obstructive nephropathy (Disease Ontology:DOID:0070314); xanthinuria type II (Disease Ontology:DOID:0070453)", "pathway": " (mmu:68591); (R-MMU-947581)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.1.9", "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0030170 pyridoxal phosphate binding;GO:0016829 lyase activity;GO:0008265 molybdenum cofactor sulfurtransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032324 molybdopterin cofactor biosynthetic process;GO:0043545 molybdopterin cofactor metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q14CH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U034-1", "uniprot_id": "METL4_MOUSE", "mass": 53306.0, "length": 471, "protein_name": "N(6)-adenine-specific methyltransferase METTL4", "gene_name": "Mettl4", "organism": "Mouse", "refseq_name": "N(6)-adenine-specific methyltransferase METTL4 isoform 1", "refseq_ac": "NP_795891", "gene_names_uniprotkb": "Mettl4", "gene_names_refseq": "2410198H06Rik; A730091E08Rik; HsT661; Mettl4", "protein_names_uniprotkb": "N(6)-adenine-specific methyltransferase METTL4; 2.1.1.-; 2.1.1.72; Methyltransferase-like protein 4; N(6)-adenine-specific DNA methyltransferase METTL4; snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4", "protein_names_refseq": "N(6)-adenine-specific DNA methyltransferase METTL4; N(6)-adenine-specific methyltransferase METTL4 isoform 1; N(6)-adenine-specific methyltransferase METTL4; methyltransferase like 4; methyltransferase-like protein 4; snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4", "tax_id": 10090, "disease": "", "pathway": " (mmu:76781)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30982744;32427889;38224757", "class_list": "", "function": "It has been shown that 6methyladenine (6 mA) deposition and removal are catalyzed by the Mettl4 methyltransferase and Alkbh4 dioxygenase, respectively, and that 6mA accumulation in genic elements corresponds with transcriptional silencing., [RefSeq, PubMed]; METTL4 mediated-N6-methyladenosine promotes acute lung injury by activating ferroptosis in alveolar epithelial cells., [RefSeq, PubMed]; N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA (PubMed:30982744). Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation (By similarity). Internal m6A(m) methylation of snRNAs regulates RNA splicing (By similarity). Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:30982744). The existence of N(6)-methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6)-adenine-specific DNA methyltransferase activity of METTL4 in vivo (By similarity). Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending (By similarity). N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (PubMed:30982744)., [UniProtKB, PubMed, UniProtKB]; Regulation of Adipocyte Differentiation by METTL4, a 6 mA Methylase. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.-;2.1.1.72", "go_molecular_function": "GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity;GO:0003676 nucleic acid binding;GO:0008173 RNA methyltransferase activity;GO:0106347 U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:1990204 oxidoreductase complex", "go_biological_process": "GO:0043484 regulation of RNA splicing;GO:0045814 negative regulation of gene expression, epigenetic;GO:0032259 methylation;GO:0090296 regulation of mitochondrial DNA replication;GO:0120049 snRNA (adenine-N6)-methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3U034-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UBZ5-1", "uniprot_id": "MI4GD_MOUSE", "mass": 25493.0, "length": 222, "protein_name": "MIF4G domain-containing protein", "gene_name": "Mif4gd", "organism": "Mouse", "refseq_name": "MIF4G domain-containing protein isoform 1", "refseq_ac": "NP_001230513", "gene_names_uniprotkb": "Mif4gd", "gene_names_refseq": "1110014L05Rik; 2310075G12Rik; Mif4gd", "protein_names_uniprotkb": "MIF4G domain-containing protein", "protein_names_refseq": "MIF4G domain-containing protein isoform 1; MIF4G domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69674)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05CE9;Q7TMH3;Q8R333", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0008494 translation activator activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0062073 histone mRNA stem-loop binding complex", "go_biological_process": "GO:0006446 regulation of translational initiation;GO:0002191 cap-dependent translational initiation;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UBZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UE17-1", "uniprot_id": "MEX3D_MOUSE", "mass": 65329.0, "length": 643, "protein_name": "RNA-binding protein MEX3D", "gene_name": "Mex3d", "organism": "Mouse", "refseq_name": "RNA-binding protein MEX3D", "refseq_ac": "NP_941017", "gene_names_uniprotkb": "Mex3d; Rkhd1", "gene_names_refseq": "Mex3d; Rkhd1", "protein_names_uniprotkb": "RNA-binding protein MEX3D; RING finger and KH domain-containing protein 1", "protein_names_refseq": "RING finger and KH domain-containing protein 1; RNA-binding protein MEX3D; mex3 homolog D; ring finger (C3HC4 type) and KH domain containing 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:237400)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;25428506;32782141", "class_list": "", "function": "RNA binding protein, may be involved in post-transcriptional regulatory mechanisms., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003730 mRNA 3'-UTR binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0050779 RNA destabilization;GO:0006402 mRNA catabolic process;GO:0061157 mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UE17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UQI9-1", "uniprot_id": "MINY4_MOUSE", "mass": 82937.0, "length": 744, "protein_name": "Probable ubiquitin carboxyl-terminal hydrolase MINDY-4", "gene_name": "Mindy4", "organism": "Mouse", "refseq_name": "probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform 1", "refseq_ac": "NP_001136253", "gene_names_uniprotkb": "Mindy4; Fam188b", "gene_names_refseq": "C330043M08Rik; Fam188b; Gm1406; Mindy4", "protein_names_uniprotkb": "Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; 3.4.19.12; Probable deubiquitinating enzyme MINDY-4", "protein_names_refseq": "family with sequence similarity 188, member B; probable deubiquitinating enzyme MINDY-4; probable ubiquitin carboxyl-terminal hydrolase FAM188B; probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform 1; probable ubiquitin carboxyl-terminal hydrolase MINDY-4; protein FAM188B", "tax_id": 10090, "disease": "", "pathway": " (mmu:330323)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17971504;21183079;21750661;30084848;40021952;40885482", "class_list": "", "function": "C330043M08Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins., [UniProtKB, UniProtKB]; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C472", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UQI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4VC33-1", "uniprot_id": "MAEA_MOUSE", "mass": 45336.0, "length": 396, "protein_name": "E3 ubiquitin-protein transferase MAEA", "gene_name": "Maea", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein transferase MAEA isoform 1", "refseq_ac": "NP_067475", "gene_names_uniprotkb": "Maea; Emp", "gene_names_refseq": "1110030D19Rik; EMP; Gid9; Maea", "protein_names_uniprotkb": "E3 ubiquitin-protein transferase MAEA; 2.3.2.27; Erythroblast macrophage protein; Macrophage erythroblast attacher", "protein_names_refseq": "E3 ubiquitin-protein transferase MAEA isoform 1; E3 ubiquitin-protein transferase MAEA; erythroblast macrophage protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:59003); (R-MMU-9861718)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16510120;16707498;17071116;18501646;21750661;25428506;30779550;31132907;31219806;33947846;34428180", "class_list": "", "function": "Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (PubMed:16707498). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis (PubMed:16707498, PubMed:17071116). Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (PubMed:16707498). May contribute to nuclear architecture and cells division events (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Emp null model provides an experimental system to study enucleation process and to evaluate the function of macrophages in definitive erythropoiesis., [RefSeq, PubMed]; Emp plays a cell intrinsic role in the erythroid lineage, [RefSeq, PubMed]; MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Temporal and spatial expression of Emp correlates with its role in erythroblastic island formation, suggesting that Emp may be involved in multiple cellular functions., [RefSeq, PubMed]; The data showed that erythroblast macrophage protein (EMP) is ubiquitously expressed in macrophages at all of the tissues of the lupus and control mice. However, the expression of EMP in bone marrow and liver tissues of lupus mice was higher than in the control mice, which indicates that EMP may be important in the development of systemic lupus erythematosus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFH0;Q3U7T6;Q5XKE6;Q8BPI3;Q8BSA1;Q9JK49", "ec_number_list": "1.1.1.27;2.7.10.2;2.7.11.1;2.7.1.40;2.3.2.27", "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005856 cytoskeleton", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0007155 cell adhesion;GO:0051301 cell division;GO:0007010 cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q4VC33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61532-1", "uniprot_id": "MK06_MOUSE", "mass": 82199.0, "length": 720, "protein_name": "Mitogen-activated protein kinase 6", "gene_name": "Mapk6", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 6", "refseq_ac": "NP_056621", "gene_names_uniprotkb": "Mapk6; Erk3; Prkm4; Prkm6", "gene_names_refseq": "2610021I23Rik; D130053K17Rik; Erk3; Mapk4; Mapk63; Mapk6; Prkm4; Prkm6", "protein_names_uniprotkb": "Mitogen-activated protein kinase 6; 2.7.11.24; ERK-3; Extracellular signal-regulated kinase 3; MAP kinase 6; MAPK 6", "protein_names_refseq": "Erk-3 related; MAP kinase 6; extracellular signal-regulated kinase 3; mitogen activated protein kinase 4; mitogen-activated protein kinase 6; protein kinase, mitogen activated kinase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:50772); (R-MMU-5687128)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10657254;12504858;12808096;15538386;15577943;16973613;18720373;19473979;25428506;30779550;33649389;34203471;34428180;37828378;8444355", "class_list": "", "function": "Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle., [UniProtKB, PubMed, PubMed]; ERK3 biological activity is regulated by its cellular abundance through the control of protein stability, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497T9;Q6YKB0;Q7TT30;Q80XH5;Q922U4;Q9JLU6", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.3.1.48;2.7.12.2;2.7.12.1;2.7.11.22;3.4.19.12;2.7.10.2;2.7.11.-;2.7.11.4;3.4.25.1;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;3.1.3.16;3.1.3.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0032156 septin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0060999 positive regulation of dendritic spine development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q61532-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61885-1", "uniprot_id": "MOG_MOUSE", "mass": 28271.0, "length": 246, "protein_name": "Myelin-oligodendrocyte glycoprotein", "gene_name": "Mog", "organism": "Mouse", "refseq_name": "myelin-oligodendrocyte glycoprotein precursor", "refseq_ac": "NP_034944", "gene_names_uniprotkb": "Mog", "gene_names_refseq": "B230317G11Rik; Mog", "protein_names_uniprotkb": "Myelin-oligodendrocyte glycoprotein", "protein_names_refseq": "myelin-oligodendrocyte glycoprotein precursor", "tax_id": 10090, "disease": "optic neuritis (Disease Ontology:DOID:1210); multiple sclerosis (Disease Ontology:DOID:2377); neuromyelitis optica (Disease Ontology:DOID:8869); narcolepsy (Disease Ontology:DOID:8986)", "pathway": " (mmu:17441)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12960396;1373175;17157925;21765430;22412888;22566807;22688423;22745378;30899004;33300544;7829100;8367453;9334726", "class_list": "", "function": "Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70364;Q62003", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009986 cell surface;GO:0043209 myelin sheath;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q61885-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZQ89-1", "uniprot_id": "MARH6_MOUSE", "mass": 102273.0, "length": 909, "protein_name": "E3 ubiquitin-protein ligase MARCHF6", "gene_name": "Marchf6", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MARCHF6 isoform 1", "refseq_ac": "NP_766194", "gene_names_uniprotkb": "Marchf6; Kiaa0597; March6", "gene_names_refseq": "3830408G03; F830029L24Rik; March6; Marchf6; mKIAA0597", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF6; 2.3.2.27; MARCH-VI; Membrane-associated RING finger protein 6; Membrane-associated RING-CH protein VI; RING-type E3 ubiquitin transferase MARCHF6", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH6; E3 ubiquitin-protein ligase MARCHF6 isoform 1; E3 ubiquitin-protein ligase MARCHF6; MARCH-VI; RING-type E3 ubiquitin transferase MARCH6; RING-type E3 ubiquitin transferase MARCHF6; membrane-associated RING finger protein 6; membrane-associated RING-CH protein VI; membrane-associated ring finger (C3HC4) 6", "tax_id": 10090, "disease": "familial adult myoclonic epilepsy 3 (Disease Ontology:DOID:0111695)", "pathway": " (mmu:223455)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "25428506;30084848;31219806;31599954;34203471;34428180;35941365;36210013;37421621", "class_list": "", "function": "Endoplasmic reticulum membrane-associated E3 ubiquitin ligase that plays a critical role in mitigating endoplasmic reticulum stress, the regulation of cholesterol and lipid homeostasis, and ferroptosis. Acts as a pivotal component of both the Ac/N-degron pathway (targeting the N-terminal acetyl group of substrates) and the ER-associated protein degradation-cytosol (ERAD-C) pathway (targeting misfolded substrates). For instance, mediates the degradation of Ac/N-degron-bearing proteins such as the G protein regulator RGS2 and the lipid droplet protein PLIN2 (By similarity). Suppresses endoplasmic reticulum stress and ferroptosis through cytosolic POMC degradation (By similarity). Prevents ferroptosis by acting as a NADPH sensor during lipid peroxidation through its C-terminal regulatory region. Facilitates also the degradation of selected endoplasmic reticulum proteins by associating with signal peptide peptidase for the turnover of endogenous tail-anchored proteins. Promotes ubiquitination of DIO2, leading to its degradation. By ubiquitinating and thereby modulating the stability of many proteins of the cholesterol pathway including SQLE, CYP51A1, CYP11A1 and HMGCR, acts as a crucial post-translational regulator of cholesterol synthesis (By similarity)., [UniProtKB, UniProtKB]; Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons., [RefSeq, PubMed]; The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCS1;Q80V02;Q80VC7;Q8BJA0;Q8BXX6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0010498 proteasomal protein catabolic process;GO:0036503 ERAD pathway;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6ZQ89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN02-1", "uniprot_id": "MED26_MOUSE", "mass": 64680.0, "length": 588, "protein_name": "Mediator of RNA polymerase II transcription subunit 26", "gene_name": "Med26", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 26", "refseq_ac": "NP_081761", "gene_names_uniprotkb": "Med26; Crsp7", "gene_names_refseq": "5730493L18Rik; Crsp7; Med26", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 26; CRSP complex subunit 7; Cofactor required for Sp1 transcriptional activation subunit 7; Mediator complex subunit 26", "protein_names_refseq": "CRSP complex subunit 7; cofactor required for Sp1 transcriptional activation subunit 7; cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa; mediator of RNA polymerase II transcription subunit 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:70625)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20111005;21183079;34428180", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUP9;Q8R1G7;Q9CS67", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TN02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNS2-1", "uniprot_id": "MIC10_MOUSE", "mass": 8567.0, "length": 76, "protein_name": "MICOS complex subunit Mic10", "gene_name": "Micos10", "organism": "Mouse", "refseq_name": "MICOS complex subunit Mic10", "refseq_ac": "NP_001156478", "gene_names_uniprotkb": "Micos10; Mic10; Minos1", "gene_names_refseq": "2310028O11Rik; Micos10; Minos1", "protein_names_uniprotkb": "MICOS complex subunit Mic10; Mitochondrial inner membrane organizing system protein 1", "protein_names_refseq": "MICOS complex subunit Mic10; UPF0327 protein C1orf151 homolog; mitochondrial inner membrane organizing system 1; mitochondrial inner membrane organizing system protein 1; novel DUF543 domain containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:433771)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25605945;35820727;35984892;36288343", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALL2;Q3U6N5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0061617 MICOS complex", "go_biological_process": "GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TNS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80T91-1", "uniprot_id": "MEG11_MOUSE", "mass": 116059.0, "length": 1091, "protein_name": "Multiple epidermal growth factor-like domains protein 11", "gene_name": "Megf11", "organism": "Mouse", "refseq_name": "multiple epidermal growth factor-like domains protein 11 isoform 1 precursor", "refseq_ac": "NP_001127871", "gene_names_uniprotkb": "Megf11; Kiaa1781", "gene_names_refseq": "2410080H04Rik; D130061K05; Megf11", "protein_names_uniprotkb": "Multiple epidermal growth factor-like domains protein 11; Multiple EGF-like domains protein 11", "protein_names_refseq": "multiple EGF-like domains protein 11; multiple epidermal growth factor-like domains protein 11 isoform 1 precursor; multiple epidermal growth factor-like domains protein 11", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:214058); (R-MMU-3000157); (R-MMU-381426); (R-MMU-446107); (R-MMU-8874081); (R-MMU-8957275); (R-MMU-9913351)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "21750661;22407321;35398017", "class_list": "", "function": "In mouse, two related transmembrane proteins, MEGF10 and MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells Publication Status: Online-Only, [RefSeq, PubMed]; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements., [UniProtKB, PubMed]; Overexpression of multiple epidermal growth factor like domains 11 rescues anoikis survival through tumor cells-platelet interaction in triple negative breast Cancer cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV46;Q8BKK7;Q8BX64", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0016323 basolateral plasma membrane;GO:0005604 basement membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0034446 substrate adhesion-dependent cell spreading;GO:0010842 retina layer formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80T91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q812G0-1", "uniprot_id": "MGT4A_MOUSE", "mass": 61480.0, "length": 535, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "Mgat4a", "organism": "Mouse", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2", "refseq_ac": "NP_001277730", "gene_names_uniprotkb": "Mgat4a", "gene_names_refseq": "9530018I07Rik; GnT-IVa; Mgat4a; glcNAc-T-IVa", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A; 2.4.1.145; GlcNAc-T IVa; GnT-IVa; N-acetylglucosaminyltransferase IVa; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa", "protein_names_refseq": "N-acetylglucosaminyltransferase IVa; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:269181); (R-MMU-381426); (R-MMU-8957275); (R-MMU-975577)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "16377570;21750661;24769441;30084848;30779550;31219806;35820727;35854001;37295747", "class_list": "glycogene;glycosyltransferase", "function": "Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A). Publication Status: Online-Only, [RefSeq, PubMed]; Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:16377570). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (PubMed:16377570)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Mutagenesis of this gene encoding GnT-4a glycosyltransferase is studied and its association with Diabetes type 2., [RefSeq, PubMed]; N-glycosylation by N-acetylglucosaminyltransferase IVa enhances the interaction of integrin beta1 with vimentin and promotes hepatocellular carcinoma cell motility., [RefSeq, PubMed]; Our results suggest that let-7c may inhibit the metastatic ability of Hca-F cells, at least partially, via repressing Mgat4a activity. Erratum:[Int J Biochem Cell Biol. 2021 Jun;135:105979. doi: 10.1016/j.biocel.2021.105979. PMID: 33992518], [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQT1;Q80UI0", "ec_number_list": "3.4.24.81;3.6.4.-;5.3.4.1;3.4.21.69;2.7.11.1;1.11.1.27;1.16.3.1;1.11.1.9;1.16.3.4;3.4.21.-;2.4.1.145;3.1.1.4;3.1.1.3;1.8.3.2;3.1.1.98;3.2.1.51;3.4.21.112", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity;GO:0008453 alanine-glyoxylate transaminase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0005795 Golgi stack", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0046487 glyoxylate metabolic process;GO:0006487 protein N-linked glycosylation;GO:0006491 N-glycan processing", "synthesized_glycan_count": 3884, "hit_score": 1.0, "record_id": "Q812G0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMK1-1", "uniprot_id": "METL2_MOUSE", "mass": 43912.0, "length": 389, "protein_name": "tRNA N(3)-cytidine methyltransferase METTL2", "gene_name": "Mettl2", "organism": "Mouse", "refseq_name": "tRNA N(3)-cytidine methyltransferase METTL2", "refseq_ac": "NP_766155", "gene_names_uniprotkb": "Mettl2; D11Ertd768e", "gene_names_refseq": "2810438F06Rik; C130031G21Rik; D11Ertd768e; METL; Mettl2; PSENIP1", "protein_names_uniprotkb": "tRNA N(3)-cytidine methyltransferase METTL2; 2.1.1.-; Methyltransferase-like protein 2", "protein_names_refseq": "methyltransferase like 2; methyltransferase-like protein 2; tRNA N(3)-cytidine methyltransferase METTL2; tRNA N(3)-methylcytidine methyltransferase METTL2", "tax_id": 10090, "disease": "", "pathway": " (mmu:52686)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "28655767;34428180;35820727", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767). N(3)-methylcytidine methylation by METTL2 requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5T7;Q5EBH8;Q8BXC2", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0016427 tRNA (cytidine) methyltransferase activity;GO:0052735 tRNA (cytidine-3-)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BMK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1Q4-1", "uniprot_id": "METRN_MOUSE", "mass": 31469.0, "length": 291, "protein_name": "Meteorin", "gene_name": "Metrn", "organism": "Mouse", "refseq_name": "meteorin precursor", "refseq_ac": "NP_598480", "gene_names_uniprotkb": "Metrn; Hyrac", "gene_names_refseq": "1810034B16Rik; EyeLinc16; Hyrac; Metrn", "protein_names_uniprotkb": "Meteorin; Hypoxia/reoxygenation regulatory factor", "protein_names_refseq": "hypoxia/reoxygenation regulatory factor in astrocytes; meteorin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:70083)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15085178;19259827;21750661;21913724;28245108", "class_list": "", "function": "Data show that Meteorin is expressed in the central nervous system both during development and in adult mice., [RefSeq, PubMed]; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q45G31;Q6P6N6;Q8CI64;Q922A8", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0050772 positive regulation of axonogenesis;GO:0010001 glial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C1Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCB5-1", "uniprot_id": "MET24_MOUSE", "mass": 40631.0, "length": 363, "protein_name": "Probable methyltransferase-like protein 24", "gene_name": "Mettl24", "organism": "Mouse", "refseq_name": "probable methyltransferase-like protein 24 precursor", "refseq_ac": "NP_808461", "gene_names_uniprotkb": "Mettl24", "gene_names_refseq": "9030224M15Rik; Mettl24", "protein_names_uniprotkb": "Probable methyltransferase-like protein 24; 2.1.1.-", "protein_names_refseq": "UPF0624 protein C6orf186 homolog; methyltransferase-like protein 24; probable methyltransferase-like protein 24 precursor; probable methyltransferase-like protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:327747)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable methyltransferase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CCB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K310-1", "uniprot_id": "MATR3_MOUSE", "mass": 94630.0, "length": 846, "protein_name": "Matrin-3", "gene_name": "Matr3", "organism": "Mouse", "refseq_name": "matrin-3 isoform a", "refseq_ac": "NP_034901", "gene_names_uniprotkb": "Matr3", "gene_names_refseq": "1110061A14Rik; 2810017I02Rik; D030046F20Rik; Matr3; mKIAA0723", "protein_names_uniprotkb": "Matrin-3", "protein_names_refseq": "matrin-3 isoform a", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 21 (Disease Ontology:DOID:0060212)", "pathway": " (mmu:17184)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "16452087;17242355;19131326;19144319;20173027;21183079;21540332;21750661;21952136;22645316;23806337;24788674;25153642;25605945;28135057;28528544;29237092;30194346;31219806;32848054;33300544;34428180;34716321;34887587;35820727;36689813;36852467;37453647;38936659;39627609;40021952;40885482", "class_list": "", "function": "Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture. Publication Status: Online-Only, [RefSeq, PubMed]; Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor., [RefSeq, PubMed]; MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS., [RefSeq, PubMed]; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0035198 miRNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016363 nuclear matrix", "go_biological_process": "GO:0003170 heart valve development;GO:0045087 innate immune response;GO:0010608 post-transcriptional regulation of gene expression;GO:0003281 ventricular septum development;GO:0002218 activation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q8K310-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0Z5-1", "uniprot_id": "MFRN2_MOUSE", "mass": 39358.0, "length": 364, "protein_name": "Mitoferrin-2", "gene_name": "Slc25a28", "organism": "Mouse", "refseq_name": "mitoferrin-2 isoform 1", "refseq_ac": "NP_660138", "gene_names_uniprotkb": "Slc25a28; Mfrn2", "gene_names_refseq": "Mfrn2; Mrs3/4; Slc25a28", "protein_names_uniprotkb": "Mitoferrin-2; MRS3/4; Mitochondrial RNA-splicing protein 3/4 homolog; Mitochondrial iron transporter 2; Solute carrier family 25 member 28", "protein_names_refseq": "mitochondrial RNA-splicing protein 3/4 homolog; mitochondrial iron transporter 2; mitoferrin-2 isoform 1; mitoferrin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:246696)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16511496;21750661;31219806;33711329;34428180;36210013;38085466;38736904;38931165", "class_list": "", "function": "Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2. Publication Status: Online-Only, [RefSeq, PubMed]; Microglial SLC25A28 Deficiency Ameliorates the Brain Injury After Intracerebral Hemorrhage in Mice by Restricting Aerobic Glycolysis., [RefSeq, PubMed]; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis., [RefSeq, PubMed]; SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4J8;Q8K4J9;Q8R578", "ec_number_list": "", "go_molecular_function": "GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0048250 iron import into the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R0Z5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3N2-1", "uniprot_id": "MFS6L_MOUSE", "mass": 63430.0, "length": 586, "protein_name": "Major facilitator superfamily domain-containing protein 6-like", "gene_name": "Mfsd6l", "organism": "Mouse", "refseq_name": "major facilitator superfamily domain-containing protein 6-like", "refseq_ac": "NP_666116", "gene_names_uniprotkb": "Mfsd6l", "gene_names_refseq": "Mfsd6l", "protein_names_uniprotkb": "Major facilitator superfamily domain-containing protein 6-like", "protein_names_refseq": "major facilitator superfamily domain-containing protein 6-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:215723)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24129315;38909778", "class_list": "", "function": "Deficiency of MFSD6L, an acrosome membrane protein, causes oligoasthenoteratozoospermia in humans and mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R3N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCV9-1", "uniprot_id": "MF4B1_MOUSE", "mass": 45686.0, "length": 425, "protein_name": "Sodium-dependent glucose transporter 1A", "gene_name": "Mfsd4b1", "organism": "Mouse", "refseq_name": "sodium-dependent glucose transporter 1A", "refseq_ac": "NP_659070", "gene_names_uniprotkb": "Mfsd4b1; Naglt1a", "gene_names_refseq": "Mfsd4b1; Naglt1a", "protein_names_uniprotkb": "Sodium-dependent glucose transporter 1A; Major facilitator superfamily domain-containing protein 4B1", "protein_names_refseq": "major facilitator superfamily domain-containing protein 4B1; sodium-dependent glucose transporter 1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:215929)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VCV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDV8-1", "uniprot_id": "MITD1_MOUSE", "mass": 28847.0, "length": 249, "protein_name": "MIT domain-containing protein 1", "gene_name": "Mitd1", "organism": "Mouse", "refseq_name": "MIT domain-containing protein 1", "refseq_ac": "NP_081189", "gene_names_uniprotkb": "Mitd1", "gene_names_refseq": "1500032H18Rik; Mitd1", "protein_names_uniprotkb": "MIT domain-containing protein 1", "protein_names_refseq": "MIT domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69028)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DB13", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0016020 membrane;GO:0031902 late endosome membrane;GO:0030496 midbody", "go_biological_process": "GO:0000281 mitotic cytokinesis;GO:0061952 midbody abscission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VDV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEA4-1", "uniprot_id": "MIA40_MOUSE", "mass": 15525.0, "length": 139, "protein_name": "Mitochondrial intermembrane space import and assembly protein 40", "gene_name": "Chchd4", "organism": "Mouse", "refseq_name": "mitochondrial intermembrane space import and assembly protein 40", "refseq_ac": "NP_598689", "gene_names_uniprotkb": "Chchd4; Mia40", "gene_names_refseq": "2410012P20Rik; 2810014D17Rik; Chchd4", "protein_names_uniprotkb": "Mitochondrial intermembrane space import and assembly protein 40; Coiled-coil-helix-coiled-coil-helix domain-containing protein 4", "protein_names_refseq": "coiled-coil-helix-coiled-coil-helix domain-containing protein 4; mitochondrial intermembrane space import and assembly protein 40", "tax_id": 10090, "disease": "", "pathway": " (mmu:72170)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16185709;26004228;27687729;28492551;29704824;33751436;38157298", "class_list": "", "function": "CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise., [RefSeq, PubMed]; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (PubMed:26004228). Functions as a chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COA7, COX17, COX19, MICU1 and TIMCC/FAM136A. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake., [UniProtKB, UniProtKB, PubMed]; Ligand Binding in Allosteric Flavoproteins: Part 2. Quantitative Analysis of the Redox-Dependent Interaction of the Apoptosis-Inducing Factor (AIF) with Its Protein Partner., [RefSeq, PubMed]; Mechanistically, exercise-induced nuclear transcription factor FOXO3 binds to the CHCHD4 promoter and represses its expression, preventing the translocation of p53 to the mitochondria and thereby increasing p53 nuclear localization., [RefSeq, PubMed]; These results suggest that CHCHD4 haploinsufficiency afforded persistent neuroprotection related to reduced release of mitochondrial intermembrane space proteins. Publication Status: Online-Only, [RefSeq, PubMed]; To test whether differences in the ratio between CHCHD4 and ALR might explain tissue-specific differences in the CHCHD4 redox state, we determined the molar ratio of both proteins in different mouse tissues. Surprisingly, ALR is superstoichiometric over CHCHD4 in most tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0033108 mitochondrial respiratory chain complex assembly;GO:1990830 cellular response to leukemia inhibitory factor;GO:0034599 cellular response to oxidative stress;GO:0072655 establishment of protein localization to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VEA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VE6-1", "uniprot_id": "MK67I_MOUSE", "mass": 36265.0, "length": 317, "protein_name": "MKI67 FHA domain-interacting nucleolar phosphoprotein", "gene_name": "Nifk", "organism": "Mouse", "refseq_name": "MKI67 FHA domain-interacting nucleolar phosphoprotein", "refseq_ac": "NP_080748", "gene_names_uniprotkb": "Nifk; Mki67ip", "gene_names_refseq": "C130020J04Rik; Mki67ip; Nifk", "protein_names_uniprotkb": "MKI67 FHA domain-interacting nucleolar phosphoprotein; Nucleolar protein interacting with the FHA domain of pKI-67; mNIFK", "protein_names_refseq": "MKI67 FHA domain-interacting nucleolar phosphoprotein; Mki67 (FHA domain) interacting nucleolar phosphoprotein; mNIFK; nucleolar protein interacting with the FHA domain of pKI-67", "tax_id": 10090, "disease": "", "pathway": " (mmu:67949)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11342549;12798774;17242355;21183079;21750661;24463520;25153642;25428506;27802388;30084848;30779550;34428180", "class_list": "", "function": "NIFK, an RNA-binding nucleolar protein interacting with the fork-head associated domain of the proliferation marker protein Ki-67, is widely expressed in adult mouse tissues and up-regulated in denervated hind limb muscle, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMV9;Q8BVL4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91VE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1M5-1", "uniprot_id": "NALP5_MOUSE", "mass": 131318.0, "length": 1163, "protein_name": "NACHT, LRR and PYD domains-containing protein 5", "gene_name": "Nlrp5", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 5 isoform b", "refseq_ac": "NP_001034232", "gene_names_uniprotkb": "Nlrp5; Mater; Nalp5", "gene_names_refseq": "Mater; Nalp5; Nlrp5; Op1; PAN11", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 5; Mater protein; Maternal antigen that embryos require; OP1; Ooplasm-specific protein 1", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 5 isoform b; NACHT, LRR and PYD domains-containing protein 5; NACHT, leucine rich repeat and PYD containing 5; maternal antigen that embryos require; ooplasm-specific protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23968)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10433232;10754103;11062459;12133995;14670992;15481533;18057100;18804437;21447630;22357545;24374158;25208553;28992324;30084848;31118423;34428180;37922900;38177687", "class_list": "", "function": "Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (PubMed:11062459, PubMed:18804437, PubMed:25208553, PubMed:37922900). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:37922900). They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (PubMed:37922900). Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (PubMed:31118423). Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy (PubMed:31118423). Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization (PubMed:24374158). May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (PubMed:22357545)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; It was concluded that lack of Nlrp5 in oocytes triggers premature activation of the mitochondrial pool, causing mitochondrial damage that cannot be rescued by inactivation of Bax. Publication Status: Online-Only, [RefSeq, PubMed]; MATER is required for endoplasmic reticulum distribution and Ca2+ homeostasis in oocytes, likely due to defects in lattice-mediated ER positioning and/or redistribution., [RefSeq, PubMed]; Results describe a subcortical maternal complex, containing Mater, Floped, TLE6, and Filia, that is essential for preimplantation mouse embryogenesis., [RefSeq, PubMed]; This gene encodes a member of the NACHT, leucine-rich repeat, and pyrin domain containing family. Members of this family have a pyrin domain at the N-terminus, a central NACHT domain, and a C-terminal leucine-rich repeat domain. This gene encodes a maternal-effect factor that is essential for early embryonic development in the mouse. Homozygous null mutant females are sterile, and embryos die following the first cleavage. This gene is required for endoplasmic reticulum redistribution and calcium homeostasis in oocytes. In addition, ovulated oocytes mutant for this gene have abnormal mitochondrial localization and increased mitochondrial activity, which results in mitochondrial damage and early embryonic lethality. Pseudogenes of this gene have been found on chromosomes 7 and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]; Transgenic expression of MATER induces antigen-specific tolerance with a significant reduction in ovarian autoimmunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXD0;Q53ZD5;Q6VSF9;Q6VSG0;Q6VSG1;Q6VSG2;Q6VSG3;Q6VSG4;Q6VSG5;Q6XZF2;Q7TPU9;Q9JLR2", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0015631 tubulin binding;GO:0140094 structural constituent of cytoplasmic lattice", "go_cellular_component": "GO:0045179 apical cortex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0051293 establishment of spindle localization;GO:0043487 regulation of RNA stability;GO:0001701 in utero embryonic development;GO:0007015 actin filament organization;GO:0009566 fertilization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9R1M5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFE3-1", "uniprot_id": "RCOR1_MOUSE", "mass": 52715.0, "length": 480, "protein_name": "REST corepressor 1", "gene_name": "Rcor1", "organism": "Mouse", "refseq_name": "REST corepressor 1", "refseq_ac": "NP_932140", "gene_names_uniprotkb": "Rcor1; D12Wsu95e; Kiaa0071", "gene_names_refseq": "5730409O11; 6720480E22Rik; D12Wsu95e; Rcor1; Rocr1; mKIAA0071", "protein_names_uniprotkb": "REST corepressor 1; Protein CoREST", "protein_names_refseq": "REST corepressor 1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:217864); (R-MMU-3214815); (R-MMU-983231)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10734093;15907476;17242355;17707228;19144319;20346398;21183079;21750661;24227653;30059200;30442713;31917688", "class_list": "", "function": "Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation., [UniProtKB, PubMed, PubMed, PubMed]; Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "K3W4P9;Q3V092;Q8BK28;Q8CHI2", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045892 negative regulation of DNA-templated transcription;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8CFE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BX46-1", "uniprot_id": "SKOR1_MOUSE", "mass": 100245.0, "length": 964, "protein_name": "SKI family transcriptional corepressor 1", "gene_name": "Skor1", "organism": "Mouse", "refseq_name": "SKI family transcriptional corepressor 1 isoform 2", "refseq_ac": "NP_001157227", "gene_names_uniprotkb": "Skor1; Corl1; Lbxcor1", "gene_names_refseq": "C230094B15Rik; Corl1; Lbxcor1; Skor1", "protein_names_uniprotkb": "SKI family transcriptional corepressor 1; Fussel-15 homolog; Ladybird homeobox corepressor 1; Lbx1 corepressor 1; Transcriptional corepressor Corl1", "protein_names_refseq": "Lbx1 corepressor 1; SKI family transcriptional corepressor 1 isoform 2; fussel-15 homolog; ladybird homeobox 1 homolog corepressor 1; ladybird homeobox corepressor 1", "tax_id": 10090, "disease": "nervous system disease (Disease Ontology:DOID:863)", "pathway": " (mmu:207667)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15528197;17292623;21750661;25428506;34887587;36620935;38159468", "class_list": "", "function": "Corl1 interacted with Lbx1 and cooperatively repressed transcription, suggesting that it acts as a transcriptional corepressor for Lbx1 in regulating cell fate determination in the dorsal spinal cord., [RefSeq, PubMed]; Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1., [UniProtKB, PubMed]; NK-derived exosome miR-1249-3p inhibits Mycobacterium tuberculosis survival in macrophages by targeting SKOR1., [RefSeq, PubMed]; SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RQS8;Q3UYA4;Q5W8I2;Q8C0T2", "ec_number_list": "", "go_molecular_function": "GO:0046332 SMAD binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BX46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VI40-1", "uniprot_id": "TRI60_MOUSE", "mass": 54199.0, "length": 466, "protein_name": "E3 SUMO-protein ligase TRIM60", "gene_name": "Trim60", "organism": "Mouse", "refseq_name": "E3 SUMO-protein ligase TRIM60", "refseq_ac": "NP_694737", "gene_names_uniprotkb": "Trim60; 2czf45; Rnf33", "gene_names_refseq": "2czf45; Rnf33; Trim60", "protein_names_uniprotkb": "E3 SUMO-protein ligase TRIM60; RING finger protein 33", "protein_names_refseq": "E3 SUMO-protein ligase TRIM60; ring finger protein 33; tripartite motif-containing protein 60", "tax_id": 10090, "disease": "", "pathway": " (mmu:234329)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11424210;12160726;12433986;21909995;33184450", "class_list": "", "function": "E3 SUMO-protein ligase that mediates SUMOylation of TAB2 leading to inhibition of NF-kappa-B and MAPK pathways by suppressing the TRAF6/TAB2/TAK1 complex., [UniProtKB, PubMed]; Regulation of transcription and pre-mRNA processing of Rnf33 in eggs and in pre-implantation embryos, [RefSeq, PubMed]; Rnf33 and Rnf35 mRNAs are apparently transcribed from the same putative promoter and may be products of alternative splicing., [RefSeq, PubMed]; The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-kappaB activation and the innate immune response., [RefSeq, PubMed]; The first demonstration of a TRIM protein, RNF33, interacting with kinesin molecular motors, possibly contributing to kinesin-dependent mobilization along the microtubule in the testis of the mouse, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UX74", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0140082 SUMO-ubiquitin ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction;GO:0010468 regulation of gene expression;GO:0007249 canonical NF-kappaB signal transduction;GO:0038061 non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VI40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLV6-1", "uniprot_id": "PNKP_MOUSE", "mass": 57223.0, "length": 522, "protein_name": "Bifunctional polynucleotide phosphatase/kinase", "gene_name": "Pnkp", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pnkp", "gene_names_refseq": "", "protein_names_uniprotkb": "Bifunctional polynucleotide phosphatase/kinase; 2'(3')-polynucleotidase; DNA 5'-kinase/3'-phosphatase; Polynucleotide kinase-3'-phosphatase", "protein_names_refseq": "", "tax_id": 10090, "disease": "microcephaly, seizures, and developmental delay (Disease Ontology:DOID:0080457); ataxia-oculomotor apraxia 4 (Disease Ontology:DOID:0081383); Charcot-Marie-Tooth disease type 2B2 (Disease Ontology:DOID:0110179)", "pathway": " (mmu:59047); (R-MMU-5649702)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "15749016;17525332;18299400;19224205;20173027;21750661;25428506;30084848;30779550;34428180;35820727;36210013", "class_list": "", "function": "Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFA3", "ec_number_list": "2.7.1.78;3.1.3.32", "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0046403 polynucleotide 3'-phosphatase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0019005 SCF ubiquitin ligase complex;GO:0035861 site of double-strand break", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0006974 DNA damage response;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JLV6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UW53-1", "uniprot_id": "NIBA1_MOUSE", "mass": 102649.0, "length": 926, "protein_name": "Protein Niban 1", "gene_name": "Niban1", "organism": "Mouse", "refseq_name": "protein Niban 1 isoform 1", "refseq_ac": "NP_071301", "gene_names_uniprotkb": "Niban1; Fam129a; Niban", "gene_names_refseq": "Fam129a; Niban1; Niban", "protein_names_uniprotkb": "Protein Niban 1; Protein FAM129A; Protein Niban", "protein_names_refseq": "family with sequence similarity 129, member A; protein Niban 1 isoform 1; protein Niban 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:63913)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11011112;17242355;17588536;19144319;19892989;21183079;21750661;25428506;25605945;26495903;30084848;30779550;31219806;33185830;34428180;37828378", "class_list": "", "function": "Alterations in niban gene expression as a response to stress conditions in 3T3-L1 adipocytes., [RefSeq, PubMed]; Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0PJB3;Q3TD68;Q6PE79;Q9ESL7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0001933 negative regulation of protein phosphorylation;GO:0045727 positive regulation of translation;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3UW53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80206-1", "uniprot_id": "OTX2_MOUSE", "mass": 31622.0, "length": 289, "protein_name": "Homeobox protein OTX2", "gene_name": "Otx2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Otx2; Otx-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein OTX2; Orthodenticle homolog 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "combined pituitary hormone deficiency 6 (Disease Ontology:DOID:0061022); syndromic microphthalmia 5 (Disease Ontology:DOID:0111806); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "1353865;18728160;21750661;35820727;8101484", "class_list": "", "function": "Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'., [UniProtKB, UniProtKB]; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030426 growth cone;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0048852 diencephalon morphogenesis;GO:0001708 cell fate specification;GO:0022037 metencephalon development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P80206-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32114-1", "uniprot_id": "PAX2_MOUSE", "mass": 44580.0, "length": 414, "protein_name": "Paired box protein Pax-2", "gene_name": "Pax2", "organism": "Mouse", "refseq_name": "paired box protein Pax-2 isoform 7", "refseq_ac": "NP_035167", "gene_names_uniprotkb": "Pax2; Pax-2", "gene_names_refseq": "Opdc; Pax-2; Pax2", "protein_names_uniprotkb": "Paired box protein Pax-2", "protein_names_refseq": "optic disc coloboma; paired box gene 2; paired box protein Pax-2 isoform 7; paired box protein Pax-2", "tax_id": 10090, "disease": "renal coloboma syndrome (Disease Ontology:DOID:0090006); focal segmental glomerulosclerosis 7 (Disease Ontology:DOID:0111132); coloboma (Disease Ontology:DOID:12270); nephroblastoma (Disease Ontology:DOID:2154); renal Wilms' tumor (Disease Ontology:DOID:5176); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:18504)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1516825;1977574;1977575;20221250;21750661;8943028", "class_list": "", "function": "Transcription factor that may have a role in kidney cell differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E2R6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005815 microtubule organizing center;GO:0005667 transcription regulator complex;GO:0034451 centriolar satellite", "go_biological_process": "GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:0007501 mesodermal cell fate specification;GO:0021633 optic nerve structural organization;GO:0039003 pronephric field specification;GO:0061360 optic chiasma development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00196-1", "uniprot_id": "PO2F2_MOUSE", "mass": 49439.0, "length": 463, "protein_name": "POU domain, class 2, transcription factor 2", "gene_name": "Pou2f2", "organism": "Mouse", "refseq_name": "POU domain, class 2, transcription factor 2 isoform 4", "refseq_ac": "NP_001157026", "gene_names_uniprotkb": "Pou2f2; Oct2; Otf2", "gene_names_refseq": "Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2; Otf2; Pou2f2", "protein_names_uniprotkb": "POU domain, class 2, transcription factor 2; Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; OTF-2; Oct-2; Octamer-binding protein 2; Octamer-binding transcription factor 2", "protein_names_refseq": "POU domain, class 2, transcription factor 2 isoform 4; lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; octamer-binding protein 2; octamer-binding transcription factor 2", "tax_id": 10090, "disease": "immune system disease (Disease Ontology:DOID:2914)", "pathway": " (mmu:18987); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "1281152;1425197;1550677;17285328;1970171;1976089;2011512;21750661;23045607;34203471;35467530;36306010;7888080;7935477", "class_list": "", "function": "Activates octamer-containing promoters., [UniProtKB, PubMed, PubMed]; POU Domain Class 2 Transcription Factor 2 Inhibits Ferroptosis in Cerebral Ischemia Reperfusion Injury by Activating Sestrin2., [RefSeq, PubMed]; Represses some promoters and activate others (PubMed:1281152, PubMed:2011512). Activates the U2 small nuclear RNA (snRNA) promoter (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Represses some promoters and activate others., [UniProtKB, PubMed, PubMed]; The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:1281152, PubMed:2011512). Regulates IL6 expression in B cells with POU2AF1 (PubMed:23045607). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Unable to bind to the octamer motif, but can still activate the beta-casein gene promoter at low levels., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q00197;Q00198;Q00199;Q00200;Q00201;Q05882;Q3KR47;Q3U127;Q5XML1;Q5XML2;Q61995;Q61996;Q64245", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0002335 mature B cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q00196-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z176-1", "uniprot_id": "P2R3D_MOUSE", "mass": 55706.0, "length": 491, "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta", "gene_name": "Ppp2r3d", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ppp2r3d; Ppp2r3a; Ppp2r6", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta; PP2A B''-PR59; PP2A PR59; Protein phosphatase 2A, 59 kDa regulatory subunit B; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha", "protein_names_refseq": "", "tax_id": 10090, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250)", "pathway": " (R-MMU-113501); (R-MMU-69231); (R-MMU-69273)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;31219806;34418053;9927208", "class_list": "", "function": "The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. Interacts with retinoblastoma-related protein p107 (in vivo). May target PP2A core dimer to p107 resulting in dephosphorylation of p107., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005509 calcium ion binding;GO:0019888 protein phosphatase regulator activity;GO:0004723 calcium-dependent protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0000159 protein phosphatase type 2A complex;GO:0097542 ciliary tip", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0006470 protein dephosphorylation;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z176-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TS48-1", "uniprot_id": "OL180_MOUSE", "mass": 36239.0, "length": 317, "protein_name": "Olfactory receptor 5K16", "gene_name": "Or5k16", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Or5k16; Olfr180", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor 5K16; Olfactory receptor Olfr180", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:258178)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TS48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYC1-1", "uniprot_id": "PCX1_MOUSE", "mass": 258147.0, "length": 2344, "protein_name": "Pecanex-like protein 1", "gene_name": "Pcnx1", "organism": "Mouse", "refseq_name": "pecanex-like protein 1", "refseq_ac": "NP_061284", "gene_names_uniprotkb": "Pcnx1; Kiaa0805; Pcnxl1; Pcnx", "gene_names_refseq": "2900024E21Rik; 3526401J03Rik; Pcnx1; Pcnxl1; Pcnx", "protein_names_uniprotkb": "Pecanex-like protein 1; Pecanex homolog protein 1", "protein_names_refseq": "pecanex homolog protein 1; pecanex-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:54604)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30084848;34428180;35820727;40885482", "class_list": "", "function": "", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ41;Q9CUU7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9QYC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YZI9-1", "uniprot_id": "PGBD5_MOUSE", "mass": 58300.0, "length": 523, "protein_name": "PiggyBac transposable element-derived protein 5", "gene_name": "Pgbd5", "organism": "Mouse", "refseq_name": "piggyBac transposable element-derived protein 5", "refseq_ac": "NP_741958", "gene_names_uniprotkb": "Pgbd5", "gene_names_refseq": "2900019M05Rik; Pgbd5", "protein_names_uniprotkb": "PiggyBac transposable element-derived protein 5; 3.1.-.-; PiggyBac transposase 5", "protein_names_refseq": "piggyBac transposable element-derived protein 5; piggyBac transposase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:209966)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;21750661;22645316;24180413;33300544;38517960;38577941;41533792", "class_list": "", "function": "Childhood cancer mutagenesis caused by transposase-derived PGBD5., [RefSeq, PubMed]; Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway., [RefSeq, PubMed]; The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]., [RefSeq]; Transposase that mediates sequence-specific genomic rearrangements., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z077;E9PUA8;Q52KE6", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004519 endonuclease activity;GO:0004803 transposase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0098038 non-replicative DNA transposition", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "D3YZI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TC5-1", "uniprot_id": "POGK_MOUSE", "mass": 69598.0, "length": 607, "protein_name": "Pogo transposable element with KRAB domain", "gene_name": "Pogk", "organism": "Mouse", "refseq_name": "pogo transposable element with KRAB domain isoform 2", "refseq_ac": "NP_001136420", "gene_names_uniprotkb": "Pogk; Kiaa1513", "gene_names_refseq": "9130401E23Rik; BASS2; Pogk; mKIAA1513", "protein_names_uniprotkb": "Pogo transposable element with KRAB domain", "protein_names_refseq": "pogo transposable element with KRAB domain isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71592)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPJ3;Q8C887", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80TC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54990-1", "uniprot_id": "PROM1_MOUSE", "mass": 97113.0, "length": 867, "protein_name": "Prominin-1", "gene_name": "Prom1", "organism": "Mouse", "refseq_name": "prominin-1 isoform s3 precursor", "refseq_ac": "NP_001157050", "gene_names_uniprotkb": "Prom1; Proml1; Prom", "gene_names_refseq": "4932416E19Rik; AC133; CD133; Prom-1; Prom1; Proml1; Prom", "protein_names_uniprotkb": "Prominin-1; Antigen AC133 homolog; Prominin-like protein 1", "protein_names_refseq": "antigen AC133 homolog; prominin-1 isoform s3 precursor; prominin-like 1; prominin-like protein 1", "tax_id": 10090, "disease": "retinal macular dystrophy 2 (Disease Ontology:DOID:0070517); retinitis pigmentosa 41 (Disease Ontology:DOID:0110376); cone-rod dystrophy 12 (Disease Ontology:DOID:0111019); retinal degeneration (Disease Ontology:DOID:8466); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:19126)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;10980698;12514187;15316084;17109118;17283184;17498271;17874118;18654668;19228982;19349973;21750661;24375541;30084848;30779550;33300544;34203471;34418053;34428180;9356465;9389721", "class_list": "", "function": "May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis (PubMed:19228982). Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 5, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "O35408;Q80XB2;Q80XB3;Q80XB6;Q8BH12", "ec_number_list": "", "go_molecular_function": "GO:0045296 cadherin binding;GO:0042805 actinin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005929 cilium", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0045494 photoreceptor cell maintenance;GO:0010842 retina layer formation;GO:0072139 glomerular parietal epithelial cell differentiation;GO:2000768 positive regulation of nephron tubule epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "O54990-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TCG8-1", "uniprot_id": "PAQR3_MOUSE", "mass": 36212.0, "length": 311, "protein_name": "Progestin and adipoQ receptor family member 3", "gene_name": "Paqr3", "organism": "Mouse", "refseq_name": "progestin and adipoQ receptor family member 3 isoform a", "refseq_ac": "NP_940814", "gene_names_uniprotkb": "Paqr3", "gene_names_refseq": "6330415A20Rik; Paqr3; RKTG", "protein_names_uniprotkb": "Progestin and adipoQ receptor family member 3; Progestin and adipoQ receptor family member III; RKTG; Raf kinase trapping to Golgi", "protein_names_refseq": "Raf kinase trapping to Golgi; progestin and adipoQ receptor family member 3 isoform a; progestin and adipoQ receptor family member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:231474); (R-MMU-5675221)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "16044242;17724343;18550569;21750661;22828136;26311497;26834238;27124708;29331071;30831144;33249098;35710596", "class_list": "", "function": "Golgi-anchored protein which modulates its interactors acitivies by tethering them to the Golgi apparatus (PubMed:17724343, PubMed:26311497). Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi apparatus (PubMed:17724343). Acts as a positive regulator of cholesterol biosynthesis by mediating the anchoring of the SCAP:SREBP complex in the Golgi apparatus, thereby promoting SCAP:SREBF2 complex formation, potentiating SREBF2 and SREBF1 processing and enhancing lipid synthesis (PubMed:26311497). Also regulates PPARA and PPARG functions by mediating their interaction with E3 ubiquitin ligases, such as STUB1 or HUWE1, leading to their polyubiquitination and proteasome-mediated degradation (PubMed:29331071, PubMed:35710596)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Loss of PAQR3 is associated with tumorigenesis of colorectal cancers., [RefSeq, PubMed]; PAQR3 plays a pivotal role in controlling hepatic LDLR degradation and blood LDL-C level via modulating LDLR-PCSK9 interaction., [RefSeq, PubMed]; RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin., [RefSeq, PubMed]; Reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway., [RefSeq, PubMed]; Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043495 protein-membrane adaptor activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0010977 negative regulation of neuron projection development;GO:0045542 positive regulation of cholesterol biosynthetic process;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043407 negative regulation of MAP kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6TCG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIZ9-1", "uniprot_id": "NOX1_MOUSE", "mass": 68193.0, "length": 591, "protein_name": "NADPH oxidase 1", "gene_name": "Nox1", "organism": "Mouse", "refseq_name": "NADPH oxidase 1", "refseq_ac": "NP_757340", "gene_names_uniprotkb": "Nox1", "gene_names_refseq": "GP91-2; MOX1; NOH-1; NOH1; NOX1alpha; NOX1a; Nox-1; Nox1", "protein_names_uniprotkb": "NADPH oxidase 1; 1.6.3.-; NOX-1", "protein_names_refseq": "GP91 phox homolog; NADH/NADPH mitogenic oxidase subunit p65-mox; NADPH oxidase 1 alpha; NADPH oxidase 1", "tax_id": 10090, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary hypertension (Disease Ontology:DOID:6432); vascular dementia (Disease Ontology:DOID:8725); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:237038); (R-MMU-5668599); (R-MMU-9013149); (R-MMU-9013423)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "12473664;12817011;14597699;16246966;16386251;16724959;16814099;21750661;31219806;35820727", "class_list": "", "function": "A pivotal role for ROSs derived from Nox1/NADPH oxidase was suggested in the pressor response to angiotensin II by reducing the bioavailability of nitric oxide., [RefSeq, PubMed]; Expression of the Nox1 gene is regulated by alternative promoters and that the novel c-type transcript is induced under phenotypic modulation of vascular smooth muscle cells, [RefSeq, PubMed]; In situ hybridization in mouse colon reveals high Nox1 expression within the lower two-thirds of colon crypts, where epithelial cells undergo proliferation and differentiation., [RefSeq, PubMed]; NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor., [UniProtKB, PubMed, PubMed]; NADPH oxidase-dependent ROS production controls ERK1/2 activation in neuroprogenitor, hypothalamic, and lymphoid cells, [RefSeq, PubMed]; Results establish a role for NOX1 in blood pressure regulation and vascular angiotensin II response., [RefSeq, PubMed]; This gene encodes a subunit of the NADPH oxidase enzyme, which is a membrane-bound, multisubunit protein. This complex catalyzes the transfer of electrons from NADPH to molecular oxygen to produce superoxide or hydrogen peroxide and may have a role in antimicrobial killing and cell signaling. This protein binds other subunits in order to produce superoxide. In mouse, deficiency of this enzyme may be associated with changes in blood pressure. [provided by RefSeq, Jun 2013]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AEK5;Q0KKX3;Q0KKX5;Q811U2", "ec_number_list": "2.7.11.1;2.7.1.153;2.7.1.137;3.6.5.2;2.7.11.13;3.1.4.4;2.7.10.1;2.7.10.2;1.6.3.-;1.6.3.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0031267 small GTPase binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity;GO:0106292 superoxide-generating NADPH oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0014043 negative regulation of neuron maturation;GO:0001525 angiogenesis;GO:0006952 defense response;GO:0008284 positive regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CIZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBU2-1", "uniprot_id": "NAA60_MOUSE", "mass": 27507.0, "length": 242, "protein_name": "N-alpha-acetyltransferase 60", "gene_name": "Naa60", "organism": "Mouse", "refseq_name": "N-alpha-acetyltransferase 60 isoform 2", "refseq_ac": "NP_001277618", "gene_names_uniprotkb": "Naa60; Nat15", "gene_names_refseq": "1200013P24Rik; HAT4; Naa60; Nat15; NatF", "protein_names_uniprotkb": "N-alpha-acetyltransferase 60; 2.3.1.259; 2.3.1.48; HAT4; Histone acetyltransferase type B protein 4; N-acetyltransferase 15; N-alpha-acetyltransferase F; NatF", "protein_names_refseq": "N-acetyltransferase 15 (GCN5-related, putative); N-alpha-acetyltransferase 60 isoform 2; N-alpha-acetyltransferase 60; N-alpha-acetyltransferase F; histone acetyltransferase type B protein 4; natF catalytic subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:74763)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48;2.3.1.-;2.7.11.1;2.3.1.259;2.3.1.57;2.3.1.80;4.2.1.-", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004402 histone acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008283 cell population proliferation;GO:0006334 nucleosome assembly;GO:0006474 N-terminal protein amino acid acetylation;GO:0017196 N-terminal peptidyl-methionine acetylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DBU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61391-1", "uniprot_id": "NEP_MOUSE", "mass": 85702.0, "length": 750, "protein_name": "Neprilysin", "gene_name": "Mme", "organism": "Mouse", "refseq_name": "neprilysin", "refseq_ac": "NP_001276391", "gene_names_uniprotkb": "Mme", "gene_names_refseq": "6030454K05Rik; CALLA; CD10; Mme; NEP; SFE", "protein_names_uniprotkb": "Neprilysin; 3.4.24.11; Atriopeptidase; Enkephalinase; NEP; Neutral endopeptidase 24.11; Neutral endopeptidase; SFE; Skin fibroblast elastase", "protein_names_refseq": "atriopeptidase; common acute lymphoblastic leukemia antigen; enkephalinase; neprilysin; neutral endopeptidase 24.11; skin fibroblast elastase", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease axonal type 2T (Disease Ontology:DOID:0110160); cerebellar ataxia type 43 (Disease Ontology:DOID:0111745); heart conduction disease (Disease Ontology:DOID:10273); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); diarrhea (Disease Ontology:DOID:13250); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)", "pathway": " (mmu:17380); (R-MMU-2022377); (R-MMU-5578768); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;1374101;19349973;20876573;21183079;21750661;27588448;30899004;33300544;34428180", "class_list": "", "function": "Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (By similarity). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (By similarity). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (By similarity). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (By similarity). Involved in the degradation of the atrial natriuretic factor (ANF) (By similarity). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 11, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXX5;Q8K251", "ec_number_list": "3.1.3.48;3.4.15.1;3.4.-.-;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;3.6.5.2;3.4.11.2;7.6.2.-;3.4.24.11;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.6.1.-", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005813 centrosome", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0006508 proteolysis;GO:0007611 learning or memory;GO:0007613 memory;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q61391-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUL6-1", "uniprot_id": "PKHA1_MOUSE", "mass": 43371.0, "length": 383, "protein_name": "Pleckstrin homology domain-containing family A member 1", "gene_name": "Plekha1", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family A member 1 isoform 2", "refseq_ac": "NP_001333444", "gene_names_uniprotkb": "Plekha1; Tapp1", "gene_names_refseq": "C920009D07Rik; Plekha1; TAPP1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 1; PH domain-containing family A member 1; TAPP-1; Tandem PH domain-containing protein 1", "protein_names_refseq": "PH domain-containing family A member 1; TAPP-1; pleckstrin homology domain-containing family A member 1 isoform 2; pleckstrin homology domain-containing family A member 1; tandem PH domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:101476); (R-MMU-1660499)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;27859053;31219806;34428180;35820727", "class_list": "", "function": "Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study shows that TAPP1/2 double knock-out mice develop chronic germinal centers with age and show abnormal expression of B-cell activation anddevelop lupus-like characteristics including anti-DNA antibodies and deposition of immune complexes in kidneys, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK96;Q8BXU1;Q8VE13", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0030165 PDZ domain binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032587 ruffle membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0007283 spermatogenesis;GO:0035264 multicellular organism growth;GO:0009791 post-embryonic development;GO:0045184 establishment of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BUL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09046-1", "uniprot_id": "OXLA_MOUSE", "mass": 70191.0, "length": 630, "protein_name": "L-amino-acid oxidase", "gene_name": "Il4i1", "organism": "Mouse", "refseq_name": "L-amino-acid oxidase precursor", "refseq_ac": "NP_001164495", "gene_names_uniprotkb": "Il4i1; Fig1; Il4i1b", "gene_names_refseq": "Fig1; Gm21948; Il4i1b; Il4i1; LAAO; LAO; Nup62-il4i1; mFIG1", "protein_names_uniprotkb": "L-amino-acid oxidase; 1.4.3.25; 1.4.3.2; IL4-induced protein 1; Interleukin-4-induced protein 1; LAAO; LAO; Protein Fig-1; mFIG1; mIL4I1", "protein_names_refseq": "IL4-induced protein 1; Interleukin-4-induced protein 1; L-amino-acid oxidase precursor; L-amino-acid oxidase; Protein Fig-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100328588); (mmu:14204); (R-MMU-8964208)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "15383589;16029492;21469114;21750661;25778793;26495903;26599209;26740625;28011936;28405502;28951444;29187734;29288206;32152506;32818467;34428180;35984892;9122225;9798653", "class_list": "", "function": "Data showed proteome changes in alveolar epithelial cells type II exposed to an infection with A. fumigatus with IL4I1 showing the most prominent increase in abundance both, in terms of relative abundance as well as activity. Also, in the infected lungs, there was levels of IL4I1 metabolic products., [RefSeq, PubMed]; Secreted L-amino-acid oxidase that acts as a key immunoregulator (PubMed:32818467). Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively (PubMed:15383589). Also has weak L-arginine oxidase activity (By similarity). Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR (PubMed:21469114, PubMed:28405502, PubMed:32818467). IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer (By similarity). AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Also has an immunoregulatory function in some immune cell, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells (PubMed:25778793, PubMed:29288206). Also regulates M2 macrophage polarization by inhibiting T-cell activation (PubMed:26599209). Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; This locus represents naturally-occurring readthrough transcription between Nup62 (nucleoporin 62) and Il4i1 (interleukin 4 induced 1). It encodes a protein sharing similarity with the protein encoded by Il4i1, but with a longer and distinct N-terminus. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZI6;Q3T9N9;Q3U7S6;Q3V0K2;Q6Y632;Q6YBV6;Q6YDI8;Q8R2G8;Q9CXK7", "ec_number_list": "1.4.3.-;1.4.3.2;1.4.3.25", "go_molecular_function": "GO:0001716 L-amino-acid oxidase activity;GO:0106329 L-phenylalaine oxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome;GO:0001669 acrosomal vesicle;GO:0097225 sperm midpiece;GO:0001772 immunological synapse", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0006569 L-tryptophan catabolic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042130 negative regulation of T cell proliferation;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O09046-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6J4-1", "uniprot_id": "NECA3_MOUSE", "mass": 39906.0, "length": 353, "protein_name": "N-terminal EF-hand calcium-binding protein 3", "gene_name": "Necab3", "organism": "Mouse", "refseq_name": "N-terminal EF-hand calcium-binding protein 3 isoform 3", "refseq_ac": "NP_067521", "gene_names_uniprotkb": "Necab3; Apba2bp; Xb51", "gene_names_refseq": "2900010M17Rik; Apba2bp; Necab3; Nip1; XB51", "protein_names_uniprotkb": "N-terminal EF-hand calcium-binding protein 3; Amyloid-beta A4 protein-binding family A member 2-binding protein; X11L-binding protein 51; mXB51", "protein_names_refseq": "N-terminal EF-hand calcium-binding protein 3 isoform 3; X11L-binding protein 51; amyloid beta (A4) precursor protein-binding family A member 1 binding protein; amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein; amyloid beta A4 protein-binding family A member 2-binding protein; mXB51", "tax_id": 10090, "disease": "", "pathway": " (mmu:56846)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10833507;14697346;19035353;21750661;23850650", "class_list": "", "function": "Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta (By similarity). May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3 (By similarity)., [UniProtKB, UniProtKB]; Physical interactions of Nek2 with NIP1 were confirmed. In fact, Nek2 can phosphorylate NIP1 in vivo. Immunostaining experiments revealed that NIP1 is a Golgi protein., [RefSeq, PubMed]; The genes for the three Necab's, including Necab-3, were expressed in specific, non-overlapping areas of the hippocampus., [RefSeq, PubMed]; Xb51 may be required for maturation and maintenance of xb51-expressing neurons in the forebrain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L0S0;A1L0S1;A2AKE8;A2AKE9;Q3TYZ9;Q9ESR0", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0000137 Golgi cis cisterna", "go_biological_process": "GO:0019538 protein metabolic process;GO:0042984 regulation of amyloid precursor protein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D6J4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CB19-1", "uniprot_id": "PHTF2_MOUSE", "mass": 84105.0, "length": 747, "protein_name": "Protein PHTF2", "gene_name": "Phtf2", "organism": "Mouse", "refseq_name": "protein PHTF2", "refseq_ac": "NP_766580", "gene_names_uniprotkb": "Phtf2", "gene_names_refseq": "1110054G21Rik; 9530062N20Rik; Phtf2", "protein_names_uniprotkb": "Protein PHTF2", "protein_names_refseq": "protein PHTF2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68770)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;36210013", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPX6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CB19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70628-1", "uniprot_id": "PDE9A_MOUSE", "mass": 61636.0, "length": 534, "protein_name": "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "gene_name": "Pde9a", "organism": "Mouse", "refseq_name": "high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1", "refseq_ac": "NP_001157220", "gene_names_uniprotkb": "Pde9a; Pde8b", "gene_names_refseq": "PDE9A1; Pde9a", "protein_names_uniprotkb": "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; 3.1.4.35", "protein_names_refseq": "high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:18585); (R-MMU-418457)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14501210;21750661;22328573;22596207;24746365;25799991;34569183;34618683;34620617;9624145;9624146;9856478", "class_list": "", "function": "Data suggest that increases in hippocampal and amygdalar cGMP levels via blockade of PDE9 have prominent roles in consolidation of extinction learning (here, prevention of learning disorder due to cocaine neurotoxicity)., [RefSeq, PubMed]; Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9., [RefSeq, PubMed]; Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice., [RefSeq, PubMed]; PDE9A deficiency does not prevent chronic-hypoxic pulmonary hypertension in mice., [RefSeq, PubMed]; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:9624145). Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (PubMed:22328573, PubMed:24746365)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This paper describes the human Pde9 gene but discusses the comparisons between the mouse and human Pde9 genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.-;3.1.4.35;3.1.4.53;3.1.4.17;3.6.1.25;3.6.1.14", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0010613 positive regulation of cardiac muscle hypertrophy;GO:2000178 negative regulation of neural precursor cell proliferation;GO:0046068 cGMP metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O70628-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFY7-1", "uniprot_id": "PIMRE_MOUSE", "mass": 25686.0, "length": 231, "protein_name": "Protein PIMREG", "gene_name": "Pimreg", "organism": "Mouse", "refseq_name": "protein PIMREG", "refseq_ac": "NP_653109", "gene_names_uniprotkb": "Pimreg; Cats; Fam64a; Rcs1", "gene_names_refseq": "2610008F03Rik; 6720460F02Rik; CATS; Fam64a; Pimreg", "protein_names_uniprotkb": "Protein PIMREG; CALM-interactor expressed in thymus and spleen homolog; PICALM-interacting mitotic regulator; Regulator of chromosome segregation protein 1", "protein_names_refseq": "CALM-interactor expressed in thymus and spleen homolog; family with sequence similarity 64, member A; protein FAM64A; protein PIMREG; regulator of chromosome segregation protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:109212)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19144319;19383357;21750661;28667270;31061131;31219806", "class_list": "", "function": "During mitosis, may play a role in the metaphase-to-anaphase transition., [UniProtKB, UniProtKB]; Expression of a non-degradable Fam64a mutant suggested that optimum Fam64a expression and subsequent degradation by anaphase-promoting complex/cyclosome (APC/C) during the metaphase-to-anaphase transition are required for fetal cardiomyocyte division. We propose that Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates Th17 differentiation and colitis and inflammation-associated cancer by modulating transcriptional activity of STAT3, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2Z7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BFY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3P8-1", "uniprot_id": "PLRKT_MOUSE", "mass": 17261.0, "length": 147, "protein_name": "Plasminogen receptor (KT)", "gene_name": "Plgrkt", "organism": "Mouse", "refseq_name": "plasminogen receptor (KT)", "refseq_ac": "NP_080638", "gene_names_uniprotkb": "Plgrkt; 5033414D02Rik", "gene_names_refseq": "1110007H22Rik; 5033414D02Rik; Plg-R(KT); Plg-RKT; Plgrkt", "protein_names_uniprotkb": "Plasminogen receptor (KT); Plg-R(KT)", "protein_names_refseq": "plasminogen receptor (KT); transmembrane protein C9orf46 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67759)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19897580;21750661;21795689;21940822;29495105;31316511;32842150;33311441;34897983", "class_list": "", "function": "Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets., [RefSeq, PubMed]; Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes. Publication Status: Online-Only, [RefSeq, PubMed]; Plg-R(KT) plays a key role in the plasminogen-dependent regulation of macrophage invasion, chemotactic migration, and recruitment in the inflammatory response., [RefSeq, PubMed]; Plg-R(KT) was highly expressed in bovine adrenomedullary chromaffin cells, human pheochromocytoma tissue, PC12 pheochromocytoma cells, and murine hippocampus., [RefSeq, PubMed]; Plg-RKT is essential for lactogenesis and functions to maintain the appropriate stromal extracellular matrix environment, regulate epithelial cell proliferation and apoptosis, and, by regulating fibrinolysis, preserve alveolar and ductal patency., [RefSeq, PubMed]; Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9., [UniProtKB, PubMed, PubMed, PubMed]; The plasminogen receptor Plg-RKT regulates adipose function and metabolic homeostasis., [RefSeq, PubMed]; The plasminogen receptor, Plg-RKT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCJ3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0006935 chemotaxis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D3P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CV28-1", "uniprot_id": "MINY3_MOUSE", "mass": 49612.0, "length": 444, "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY-3", "gene_name": "Mindy3", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform a", "refseq_ac": "NP_077147", "gene_names_uniprotkb": "Mindy3; Carp; Fam188a", "gene_names_refseq": "1810041E18Rik; 2310047O13Rik; 5830410F13Rik; Fam188a; Mindy3", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase MINDY-3; 3.4.19.12; Deubiquitinating enzyme MINDY-3; MINDY lysine 48 deubiquitinase 3; Protein CARP", "protein_names_refseq": "caspase recruitment domain containing protein; deubiquitinating enzyme MINDY-3; family with sequence similarity 188, member A; protein FAM188A; ubiquitin carboxyl-terminal hydrolase FAM188A; ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform a; ubiquitin carboxyl-terminal hydrolase MINDY-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66960)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;25428506;31219806;34428180", "class_list": "", "function": "Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPS0;Q9DCC9", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005634 nucleus", "go_biological_process": "GO:0006508 proteolysis;GO:0006915 apoptotic process;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CV28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UVY5-1", "uniprot_id": "PCX4_MOUSE", "mass": 131243.0, "length": 1174, "protein_name": "Pecanex-like protein 4", "gene_name": "Pcnx4", "organism": "Mouse", "refseq_name": "pecanex-like protein 4 isoform 1", "refseq_ac": "NP_080603", "gene_names_uniprotkb": "Pcnx4; 1810048J11Rik; Pcnxl4", "gene_names_refseq": "1810048J11Rik; 4932413O10; Pcnx4; Pcnxl4", "protein_names_uniprotkb": "Pecanex-like protein 4; Pecanex homolog protein 4", "protein_names_refseq": "pecanex homolog protein 4; pecanex-like 4; pecanex-like protein 4 isoform 1; pecanex-like protein 4; pecanex-like protein C14orf135 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67708)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUC5;Q8BPG1;Q8VE84;Q9D8P3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UVY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TP3-1", "uniprot_id": "UBR5_MOUSE", "mass": 308352.0, "length": 2792, "protein_name": "E3 ubiquitin-protein ligase UBR5", "gene_name": "Ubr5", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase UBR5 isoform 1", "refseq_ac": "NP_001074828", "gene_names_uniprotkb": "Ubr5; Edd1; Edd; Kiaa0896", "gene_names_refseq": "Edd1; Edd; Ubr5", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UBR5; 2.3.2.26; E3 ubiquitin-protein ligase, HECT domain-containing 1; Hyperplastic discs protein homolog", "protein_names_refseq": "E3 ubiquitin-protein ligase UBR5 isoform 1; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; HECT-type E3 ubiquitin transferase UBR5; extraembryonic development; hyperplastic discs protein homolog", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); laryngeal carcinoma (Disease Ontology:DOID:2600); invasive ductal carcinoma (Disease Ontology:DOID:3008); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); gallbladder carcinoma (Disease Ontology:DOID:4948)", "pathway": " (mmu:70790)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;15282321;16055722;16479539;19008229;20173027;21183079;21750661;22872234;24129315;25428506;27299863;30084848;30779550;31219806;33293516;33819267;34203471;34428180;35820727;36210013;38278841", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:16055722, PubMed:19008229). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (By similarity). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:16055722, PubMed:19008229). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (PubMed:16055722, PubMed:19008229). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (By similarity). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (By similarity). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (By similarity). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (By similarity). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (By similarity). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (By similarity). Ubiquitinates acetylated PCK1 (By similarity). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (By similarity). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (By similarity). Plays an essential role in extraembryonic development (PubMed:15282321). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (PubMed:27299863, PubMed:33819267)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Results suggest that Edd has an essential role in extraembryonic development., [RefSeq, PubMed]; Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 33, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q698K9;Q6PEQ8;Q6PFQ9;Q80VL4;Q810V6;Q9CXE9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0070561 vitamin D receptor signaling pathway;GO:0032700 negative regulation of interleukin-17 production;GO:0006281 DNA repair;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q80TP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WC7-1", "uniprot_id": "NPAL2_MOUSE", "mass": 42091.0, "length": 383, "protein_name": "NIPA-like protein 2", "gene_name": "Nipal2", "organism": "Mouse", "refseq_name": "NIPA-like protein 2", "refseq_ac": "NP_663444", "gene_names_uniprotkb": "Nipal2; Npal2", "gene_names_refseq": "9330161F08Rik; Nipal2; Npal2", "protein_names_uniprotkb": "NIPA-like protein 2", "protein_names_refseq": "NIPA-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:223473); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CC43", "ec_number_list": "", "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015693 magnesium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91WC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGA9-1", "uniprot_id": "OXA1L_MOUSE", "mass": 48220.0, "length": 433, "protein_name": "Mitochondrial inner membrane protein OXA1L", "gene_name": "Oxa1l", "organism": "Mouse", "refseq_name": "mitochondrial inner membrane protein OXA1L", "refseq_ac": "NP_081212", "gene_names_uniprotkb": "Oxa1l", "gene_names_refseq": "1810020M02Rik; Oxa1l", "protein_names_uniprotkb": "Mitochondrial inner membrane protein OXA1L; OXA1-like protein; Oxidase assembly 1-like protein", "protein_names_refseq": "OXA1-like protein; mitochondrial inner membrane protein OXA1L; oxidase assembly 1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69089); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;31219806;31599954", "class_list": "", "function": "Mitochondrial membrane insertase that mediates the cotranslational insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK01;Q8R091;Q9D8X7", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0097177 mitochondrial ribosome binding;GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0032991 protein-containing complex;GO:0016020 membrane", "go_biological_process": "GO:0051262 protein tetramerization;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0032780 negative regulation of ATP-dependent activity;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly;GO:0051354 negative regulation of oxidoreductase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERD8-1", "uniprot_id": "PARVG_MOUSE", "mass": 37603.0, "length": 331, "protein_name": "Gamma-parvin", "gene_name": "Parvg", "organism": "Mouse", "refseq_name": "gamma-parvin isoform 1", "refseq_ac": "NP_001155972", "gene_names_uniprotkb": "Parvg", "gene_names_refseq": "Parvg", "protein_names_uniprotkb": "Gamma-parvin", "protein_names_refseq": "gamma-parvin isoform 1; gamma-parvin", "tax_id": 10090, "disease": "", "pathway": " (mmu:64099)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11171322;11722847;16479001;21750661;25605945;34428180", "class_list": "", "function": "Despite the high expression of gamma-parvin in hematopoietic cells it must play a more subtle role for blood cell homeostasis, [RefSeq, PubMed]; Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization., [RefSeq, PubMed]; Plays a role with ILK in promoting the cell adhesion and spreading of leukocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH45;Q91X89", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0034446 substrate adhesion-dependent cell spreading;GO:0071963 establishment or maintenance of cell polarity regulating cell shape;GO:0030031 cell projection assembly;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ERD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61398-1", "uniprot_id": "PCOC1_MOUSE", "mass": 50168.0, "length": 468, "protein_name": "Procollagen C-endopeptidase enhancer 1", "gene_name": "Pcolce", "organism": "Mouse", "refseq_name": "procollagen C-endopeptidase enhancer 1 precursor", "refseq_ac": "NP_032814", "gene_names_uniprotkb": "Pcolce; Pcpe1", "gene_names_refseq": "Astt-2; Astt2; P14; PCPE-1; Pcolce", "protein_names_uniprotkb": "Procollagen C-endopeptidase enhancer 1; P14; PCPE-1; Procollagen C-proteinase enhancer 1; Procollagen COOH-terminal proteinase enhancer 1; Type 1 procollagen C-proteinase enhancer protein; Type I procollagen COOH-terminal proteinase enhancer", "protein_names_refseq": "astroglial cell transcript 2; procollagen C-endopeptidase enhancer 1 precursor; procollagen C-endopeptidase enhancer 1; procollagen C-proteinase enhancer 1; procollagen COOH-terminal proteinase enhancer 1; type 1 procollagen C-proteinase enhancer protein; type I procollagen COOH-terminal proteinase enhancer", "tax_id": 10090, "disease": "", "pathway": " (mmu:18542); (R-MMU-1650814); (R-MMU-2243919)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "2027019;21750661;2256940;25428506;26220971;26495903;2689170;28011936;30084848;30779550;31219806;34369899;34428180;35148334;7523404", "class_list": "", "function": "Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity., [UniProtKB, UniProtKB, UniProtKB]; Deficiency of Procollagen C-Proteinase Enhancer 1 in Mice has No Major Impact on Cardiac Collagen and Function Under Basal Conditions., [RefSeq, PubMed]; Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35113", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0016504 peptidase activator activity;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q61398-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34985-1", "uniprot_id": "OL143_MOUSE", "mass": 35201.0, "length": 313, "protein_name": "Olfactory receptor 8C8", "gene_name": "Or8c8", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Or8c8; Mor170-6; Olfr143; Olfr7", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor 8C8; Odorant receptor K18; Olfactory receptor 143; Olfactory receptor 170-6; Olfactory receptor 7A", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:258802)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11130974;21750661;7683976", "class_list": "", "function": "Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQB3", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P34985-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47713-1", "uniprot_id": "PA24A_MOUSE", "mass": 85222.0, "length": 748, "protein_name": "Cytosolic phospholipase A2", "gene_name": "Pla2g4a", "organism": "Mouse", "refseq_name": "cytosolic phospholipase A2 isoform 1", "refseq_ac": "NP_032895", "gene_names_uniprotkb": "Pla2g4a; Cpla2; Pla2g4", "gene_names_refseq": "Pla2g4a; Pla2g4; cPLA2-alpha; cPLA2alpha; cPLA2", "protein_names_uniprotkb": "Cytosolic phospholipase A2; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2 group IVA; cPLA2", "protein_names_refseq": "Cytosolic phospholipase A2 (CPLA2); Type IV PLA2; cytosolic PLA2; cytosolic phospholipase A2 isoform 1; phospholipase A2 group IVA; phospholipase A2, group 4", "tax_id": 10090, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); brain ischemia (Disease Ontology:DOID:2316); papilloma (Disease Ontology:DOID:2615); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (mmu:18783); (R-MMU-111995); (R-MMU-1482788); (R-MMU-1482798); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483115); (R-MMU-1483166); (R-MMU-2142753); (R-MMU-418592); (R-MMU-432142); (R-MMU-6811436)", "pathway_count": 14, "publication_count": 26, "publication_id_list": "10080535;10867029;10978317;11984592;15539760;16172261;17242355;1904318;19144319;19176526;21183079;21750661;25428506;26520095;27891075;28750656;28851448;30084848;30779550;31219806;32296045;32422541;33879780;37507081;9403692;9403693", "class_list": "", "function": "Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:1904318, PubMed:9403692, PubMed:9403693). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (PubMed:9403692, PubMed:9403693). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the phospholipase A2 group IV family. This enzyme hydrolyzes membrane phospholipids, thereby releasing the polyunsaturated fatty acid, arachidonic acid. Arachidonic acid is further metabolized into eicosanoids such as leukotrienes, thromboxanes and prostaglandins, that play important roles in regulating diverse biological processes such as inflammatory responses, membrane and actin dynamics, and tumorigenesis. A rise in intracellular calcium levels results in binding of calcium to the C2 domain of this protein, and triggers the translocation from the cytosol to intracellular membranes, including the Golgi apparatus. Disruption of this gene in mice led to decreased levels of eicosonaoids and platelet-activating factor, decreased allergic symptoms, and impaired reproductive ability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;3.1.1.-;1.11.1.27;3.1.1.4;2.3.1.23;2.3.1.43;3.1.1.32;3.1.1.3;3.1.2.2;3.1.2.22;3.1.2.-;3.1.1.13;3.1.1.6;2.3.1.-;2.3.1.149;2.3.1.51;3.1.4.-", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005509 calcium ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0042588 zymogen granule;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0006663 platelet activating factor biosynthetic process;GO:0043032 positive regulation of macrophage activation;GO:0034638 phosphatidylcholine catabolic process;GO:0046456 icosanoid biosynthetic process;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P47713-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TVI8-1", "uniprot_id": "PBIP1_MOUSE", "mass": 81164.0, "length": 727, "protein_name": "Pre-B-cell leukemia transcription factor-interacting protein 1", "gene_name": "Pbxip1", "organism": "Mouse", "refseq_name": "pre-B-cell leukemia transcription factor-interacting protein 1", "refseq_ac": "NP_666243", "gene_names_uniprotkb": "Pbxip1; Hpip", "gene_names_refseq": "4732463H20Rik; Pbxip1", "protein_names_uniprotkb": "Pre-B-cell leukemia transcription factor-interacting protein 1; Hematopoietic PBX-interacting protein", "protein_names_refseq": "hematopoietic PBX-interacting protein; pre-B-cell leukemia transcription factor-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:229534)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;22383461;26495903;30059200;30659184;30899004;34668648;36852467;40021952", "class_list": "", "function": "HPIP promotes the transcription of Wnt targets by interacting with lymphoid enhancer binding factor 1 (LEF1). HPIP potentiates the transcriptional activity of LEF1 and acetylates histone H3 lysine 56 in the promoters of Wnt targets, suggesting that HPIP is an attractive target in OA regulatory network. Publication Status: Online-Only, [RefSeq, PubMed]; Hematopoietic PBX-interacting protein is a novel regulator of mammary epithelial cell differentiation., [RefSeq, PubMed]; Mouse spermatogonial stem cells expressed Tex11, Hpip, and Esr2 but not Esr1, and in cultured cells, TEX11 competed with Esr2 for binding to HPIP., [RefSeq, PubMed]; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD91;Q3TWL9;Q8R319", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0022617 extracellular matrix disassembly;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q3TVI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P8I4-1", "uniprot_id": "PCNP_MOUSE", "mass": 18963.0, "length": 178, "protein_name": "PEST proteolytic signal-containing nuclear protein", "gene_name": "Pcnp", "organism": "Mouse", "refseq_name": "PEST proteolytic signal-containing nuclear protein isoform 4", "refseq_ac": "NP_001019793", "gene_names_uniprotkb": "Pcnp", "gene_names_refseq": "1110018D06Rik; Pcnp", "protein_names_uniprotkb": "PEST proteolytic signal-containing nuclear protein; PCNP; PEST-containing nuclear protein", "protein_names_refseq": "PEST proteolytic signal-containing nuclear protein isoform 4; PEST-containing nuclear protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76302)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19131326;21183079;21750661;23806337;25428506;32782141;37507081", "class_list": "", "function": "May be involved in cell cycle regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6P8I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U0P1-1", "uniprot_id": "PALB2_MOUSE", "mass": 119097.0, "length": 1104, "protein_name": "Partner and localizer of BRCA2", "gene_name": "Palb2", "organism": "Mouse", "refseq_name": "partner and localizer of BRCA2 isoform 1", "refseq_ac": "NP_001074707", "gene_names_uniprotkb": "Palb2", "gene_names_refseq": "Palb2", "protein_names_uniprotkb": "Partner and localizer of BRCA2", "protein_names_refseq": "partner and localizer of BRCA2 isoform 1", "tax_id": 10090, "disease": "female breast cancer (Disease Ontology:DOID:0050671); Fanconi anemia complementation group N (Disease Ontology:DOID:0111094); pancreatic cancer (Disease Ontology:DOID:1793); hereditary breast ovarian cancer syndrome (Disease Ontology:DOID:5683)", "pathway": " (mmu:233826); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "20484223;21750661;25428506;31219806;31877165;35006619;35404932;35820727", "class_list": "", "function": "A key function for PALB2 is to interact with and to build up appropriate communication between BRCA1 and BRCA2., [RefSeq, PubMed]; Disrupted BRCA1-PALB2 interaction induces tumor immunosuppression and T-lymphocyte infiltration in HCC through cGAS-STING pathway., [RefSeq, PubMed]; Individual deletion of Palb2, Brca1 or Brca2 genes in pancreas per se using Pdx1-Cre was insufficient to cause tumors, but it reduced pancreata size. Concurrent expression of mutant KrasG12D and p53R270H, with tumor suppressor inactivated strains in Palb2-KPC, Brca1-KPC or Brca2-KPC, accelerated pancreatic ductal adenocarcinoma (PDAC) development. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (By similarity)., [UniProtKB]; Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZG9;Q7TMQ4;Q8CEA9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0032991 protein-containing complex;GO:1990391 DNA repair complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0043066 negative regulation of apoptotic process;GO:0035264 multicellular organism growth;GO:0009887 animal organ morphogenesis;GO:0001756 somitogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3U0P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R023-1", "uniprot_id": "PCGF1_MOUSE", "mass": 30318.0, "length": 259, "protein_name": "Polycomb group RING finger protein 1", "gene_name": "Pcgf1", "organism": "Mouse", "refseq_name": "polycomb group RING finger protein 1 isoform 1", "refseq_ac": "NP_932109", "gene_names_uniprotkb": "Pcgf1; Nspc1; Rnf68", "gene_names_refseq": "2010002K04Rik; Nspc1; Pcgf1", "protein_names_uniprotkb": "Polycomb group RING finger protein 1; NSPc1; Nervous system Polycomb-1; RING finger protein 68", "protein_names_refseq": "RING finger protein 68; nervous system Polycomb-1; nervous system polycomb 1; polycomb group RING finger protein 1 isoform 1; polycomb group RING finger protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69837)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11287196;21750661;22872234;31219806;34428180;37452641", "class_list": "", "function": "Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells., [UniProtKB, UniProtKB]; Pcgf1 gene disruption reveals primary involvement of epigenetic mechanism in neuronal subtype specification in the enteric nervous system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031519 PcG protein complex;GO:0035102 PRC1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R023-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15532-1", "uniprot_id": "NDKA_MOUSE", "mass": 17208.0, "length": 152, "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "Nme1", "organism": "Mouse", "refseq_name": "nucleoside diphosphate kinase A", "refseq_ac": "NP_032730", "gene_names_uniprotkb": "Nme1; Nm23", "gene_names_refseq": "GAAD; NDK1; NDPK A; NDPK-A; NM23-M1; NM23A; Nme1", "protein_names_uniprotkb": "Nucleoside diphosphate kinase A; 2.7.11.1; 2.7.13.3; 2.7.4.18; 2.7.4.6; 3.1.11.-; 3.1.24.-; Farnesyl diphosphate kinase NME1; GAAD; Histidine protein kinase NDK; Metastasis inhibition factor NM23; NDK1; NDP kinase A; NDPK A; NDPK-A; Non-specific serine/threonine protein kinase NME1; Nucleoside diphoshate kinase 1; Putative 3'-5'-DNA exonuclease NDK1; Putative granzyme A-activated DNA endonuclease; Tumor metastatic process-associated protein; nm23-M1", "protein_names_refseq": "NDK A; NDP kinase A; expressed in non-metastatic cells 1, protein; farnesyl diphosphate kinase NME1; histidine protein kinase NDK; metastasis inhibition factor NM23; non-metastatic cells 1, protein (NM23A) expressed in; non-specific serine/threonine protein kinase NME1; nucleoside diphoshate kinase 1; nucleoside diphosphate kinase A; nucleoside-diphosphate kinase 1; nucleotide diphosphate kinase; putative 3'-5'-DNA exonuclease NDK1; putative granzyme A-activated DNA endonuclease; tumor metastatic process-associated protein", "tax_id": 10090, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); teratoma (Disease Ontology:DOID:3307); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:18102); (R-MMU-499943); (R-MMU-9748787); (R-MMU-9755088)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "2013093;21750661;23806337;2509941;26740625;33024267;3346912;34428180;34433909;35984892;36116139;37453647;37672589;37828378", "class_list": "", "function": "Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:37672589). Also phosphorylates geranyl pyrophosphate (GPP) and farnesyl pyrophosphate (FPP), linking it to isoprenoid metabolism. Additionally, functions as a non-specific serine/threonine kinase and histidine protein kinase, transferring phosphoryl groups from its active site to target proteins. May function as a Mg(2+)-dependent single-stranded DNA endonuclease as part of the SET complex, cooperating with the 3'-5' exonuclease TREX1 to mediate apoptotic DNA fragmentation in cytotoxic T lymphocytes. Reported to nick one DNA strand, enabling TREX1 to remove nucleotides from the free 3' end, enhancing DNA damage and suppressing DNA end reannealing and repair. Has been shown to cleave double strands DNA within the 3'-portions of both 5'-SHS silencer and NHE basal promoter element of the PDGFA gene, potentially repressing its transcription. May also function as a Mg(2+)-dependent 3'-5' DNA exonuclease, excising nucleotides from 3' single-stranded DNA or DNA with 3' single strand overhangs, suggesting a role in DNA nucleolytic processing (By similarity). Involved in the regulation of tumor metastasis and cellular differentiation (PubMed:2013093, PubMed:3346912). Also required for cell motility (By similarity). May control, with NME2, AcCoA usage between histone acetylation and fatty acid synthesis, possibly by binding and releasing AcCoA at transcriptionally active chromatin regions in proximity to histone acetyltransferase (HAT) (PubMed:37672589)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients. Erratum:[Oncogene. 2021 Nov;40(45):6394. doi: 10.1038/s41388-021-02045-4. PMID: 34635800], [RefSeq, PubMed]; Extracellular vesicle expansion of PMIS-miR-210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism., [RefSeq, PubMed]; Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.4.6;2.7.4.4;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.4.3;2.7.4.14;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0008296 3'-5'-DNA exonuclease activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005769 early endosome", "go_biological_process": "GO:0006231 dTMP biosynthetic process;GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0010629 negative regulation of gene expression;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P15532-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0Y2-1", "uniprot_id": "PA21B_MOUSE", "mass": 16290.0, "length": 146, "protein_name": "Phospholipase A2", "gene_name": "Pla2g1b", "organism": "Mouse", "refseq_name": "phospholipase A2 isoform 1 precursor", "refseq_ac": "NP_035237", "gene_names_uniprotkb": "Pla2g1b; Pla2", "gene_names_refseq": "Pla2a; Pla2g1b; sPLA2IB", "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4; Group IB phospholipase A2; PLA2-Ib; Phosphatidylcholine 2-acylhydrolase 1B", "protein_names_refseq": "PLA2-Ib; group IB phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B; phospholipase A2 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18778); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483166)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10066760;10531350;10689188;21750661;21908646;24747111;29024642;36603702;38003345", "class_list": "", "function": "Inactivation of Group 1B Phospholipase A2 Enhances Disease Recovery and Reduces Experimental Colitis in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Pla2g1b inactivation suppressed diet-induced body weight gain and reduced diabetes and atherosclerosis in LDL receptor-deficient mice., [RefSeq, PubMed]; Preimplantation apoptotic endometrial caspase-3-mediated phospholipase A2 activation: a potential component in programming uterine receptivity., [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (By similarity). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (PubMed:10066760). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (By similarity). Has anti-helminth activity in a process regulated by gut microbiota (PubMed:29024642). Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (PubMed:29024642)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6K5;Q9D7E2;Q9D884", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;3.1.1.5;2.3.1.43;3.1.1.47;3.1.2.2;3.1.1.3;2.3.1.-;3.1.1.-;3.1.1.32;2.3.1.51;3.1.1.23;3.1.-.-", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity;GO:0032052 bile acid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030141 secretory granule", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0019731 antibacterial humoral response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z0Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CB65-1", "uniprot_id": "NEMP2_MOUSE", "mass": 47894.0, "length": 421, "protein_name": "Nuclear envelope integral membrane protein 2", "gene_name": "Nemp2", "organism": "Mouse", "refseq_name": "nuclear envelope integral membrane protein 2 precursor", "refseq_ac": "NP_001136119", "gene_names_uniprotkb": "Nemp2; Tmem194b", "gene_names_refseq": "5330401P04Rik; 9830163O08; Nemp2; Tmem194b", "protein_names_uniprotkb": "Nuclear envelope integral membrane protein 2", "protein_names_refseq": "nuclear envelope integral membrane protein 2 precursor; transmembrane protein 194B", "tax_id": 10090, "disease": "", "pathway": " (mmu:227094)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;32923640", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C844", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005637 nuclear inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CB65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCG6-1", "uniprot_id": "PBLD1_MOUSE", "mass": 32048.0, "length": 288, "protein_name": "Phenazine biosynthesis-like domain-containing protein 1", "gene_name": "Pbld1", "organism": "Mouse", "refseq_name": "phenazine biosynthesis-like domain-containing protein 1 isoform 1", "refseq_ac": "NP_080977", "gene_names_uniprotkb": "Pbld1; Mawbp2; Pbld", "gene_names_refseq": "0610038K03Rik; Mawbp; Pbld1; Pbld", "protein_names_uniprotkb": "Phenazine biosynthesis-like domain-containing protein 1", "protein_names_refseq": "MAWD binding protein homolog 1; phenazine biosynthesis-like domain-containing protein 1 isoform 1; phenazine biosynthesis-like domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68371)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;34059646;39362857;39589880;39779683", "class_list": "", "function": "Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication. Enhances IRF3-mediated innate immune signaling and promotes apoptotic cell death, thereby suppressing viral replication. Facilitates virus-induced type I interferon (IFN-I) signaling by promoting IRF3 phosphorylation. Upregulates the type I interferon (IFN-I) response by activating the NF-kappaB signaling pathway. This may occur through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCF3", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003824 catalytic activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0030277 maintenance of gastrointestinal epithelium;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002230 positive regulation of defense response to virus by host;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DCG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K458-1", "uniprot_id": "PKR2_MOUSE", "mass": 43375.0, "length": 381, "protein_name": "Prokineticin receptor 2", "gene_name": "Prokr2", "organism": "Mouse", "refseq_name": "prokineticin receptor 2", "refseq_ac": "NP_659193", "gene_names_uniprotkb": "Prokr2; Gpr73l1; Pkr2", "gene_names_refseq": "B830005M06Rik; EG-VEGRF2; Gpcr73l1; Gpr73l1; PKR2; Prokr2", "protein_names_uniprotkb": "Prokineticin receptor 2; G protein-coupled receptor 73-like 1; PK-R2", "protein_names_refseq": "G protein-coupled receptor 73-like 1; PK-R2; prokineticin receptor 2", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 3 with or without anosmia (Disease Ontology:DOID:0090092)", "pathway": " (mmu:246313); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12024206;21750661;30084848;31219806;34428180", "class_list": "", "function": "Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AMQ8;Q80XQ0;Q8BIR4", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004983 neuropeptide Y receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K458-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZV7-1", "uniprot_id": "NAGA_MOUSE", "mass": 43501.0, "length": 409, "protein_name": "N-acetylglucosamine-6-phosphate deacetylase", "gene_name": "Amdhd2", "organism": "Mouse", "refseq_name": "N-acetylglucosamine-6-phosphate deacetylase", "refseq_ac": "NP_766523", "gene_names_uniprotkb": "Amdhd2", "gene_names_refseq": "5730457F11Rik; Amdhd2", "protein_names_uniprotkb": "N-acetylglucosamine-6-phosphate deacetylase; 3.5.1.25; Amidohydrolase domain-containing protein 2; GlcNAc 6-P deacetylase", "protein_names_refseq": "N-acetylglucosamine-6-phosphate deacetylase; amidohydrolase domain-containing protein 2; glcNAc 6-P deacetylase; putative N-acetylglucosamine-6-phosphate deacetylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:245847); (R-MMU-446210)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;22692205;25428506;31219806;34428180", "class_list": "glycogene", "function": "Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK10", "ec_number_list": "3.5.1.25", "go_molecular_function": "GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006046 N-acetylglucosamine catabolic process;GO:0019262 N-acetylneuraminate catabolic process;GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process;GO:0006044 N-acetylglucosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8JZV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XJY4-1", "uniprot_id": "PARL_MOUSE", "mass": 41964.0, "length": 377, "protein_name": "Presenilin-associated rhomboid-like protein, mitochondrial", "gene_name": "Parl", "organism": "Mouse", "refseq_name": "presenilin-associated rhomboid-like protein, mitochondrial isoform 1 precursor", "refseq_ac": "NP_001005767", "gene_names_uniprotkb": "Parl; Psarl", "gene_names_refseq": "D16Ertd607e; PRO2207; PSARL1; PSENIP2; Parl; Psarl", "protein_names_uniprotkb": "Presenilin-associated rhomboid-like protein, mitochondrial; 3.4.21.105; Mitochondrial intramembrane-cleaving protease PARL", "protein_names_refseq": "mitochondrial intramembrane-cleaving protease PARL; presenilin-associated rhomboid-like protein, mitochondrial isoform 1 precursor; presenilin-associated rhomboid-like protein, mitochondrial; presenilins-associated rhomboid-like protein, mitochondrial", "tax_id": 10090, "disease": "myopia (Disease Ontology:DOID:11830); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); Leigh disease (Disease Ontology:DOID:3652); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:381038); (R-MMU-8949664)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16839884;18288109;19680265;20444421;21750661;36658222;37505079;38182793", "class_list": "", "function": "Hax1, is required to suppress apoptosis in lymphocytes and neurons; suppression requires the interaction of Hax1 with the mitochondrial proteases Parl and HtrA2 Erratum:[Nature. 2008 Apr 17;452(7189):900], [RefSeq, PubMed]; Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis. Erratum:[Elife. 2024 Sep 13;13:e103278. doi: 10.7554/eLife.103278. PMID: 39268597] Publication Status: Online-Only, [RefSeq, PubMed]; Parl-/- mitochondria display reduced levels of OPA1, and OPA1 specifically targeted to IMS complements Parl-/- cells, substantiating the importance of PARL in OPA1 processing.(PARL protein, mouse), [RefSeq, PubMed]; Required for the control of apoptosis during postnatal growth (PubMed:16839884). Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (PubMed:16839884). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity). Promotes cleavage of serine/threonine-protein phosphatase PGAM5 in damaged mitochondria in response to loss of mitochondrial membrane potential (By similarity). Mediates differential cleavage of PINK1 and PGAM5 depending on the health status of mitochondria, disassociating from PINK1 and associating with PGAM5 in response to mitochondrial membrane potential loss (By similarity). Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide (By similarity). Promotes processing of DIABLO/SMAC in the mitochondrion which is required for DIABLO apoptotic activity (By similarity). Mediates STARD7 processing which regulates STARD7 location between mitochodria and cytosol (PubMed:36658222). Also required for cleavage of TTC19 (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Results indicate a different function and mechanism of Hax1 in apoptosis and re-opens the question of whether mammalian PARL, in addition to apoptosis, regulates mitochondrial stress response through Omi/HtrA2 processing., [RefSeq, PubMed]; Suppression of PARL protein in healthy myotubes lowered mitochondrial mass and insulin-stimulated glycogen synthesis and increased reactive oxygen species production., [RefSeq, PubMed]; The mitochondrial protease PARL is required for spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9T5;Q641T5", "ec_number_list": "3.4.24.-;3.6.-.-;3.4.21.105", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0030162 regulation of proteolysis;GO:2000377 regulation of reactive oxygen species metabolic process;GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5XJY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D114-1", "uniprot_id": "MESH1_MOUSE", "mass": 20262.0, "length": 179, "protein_name": "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1", "gene_name": "Hddc3", "organism": "Mouse", "refseq_name": "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 1", "refseq_ac": "NP_081088", "gene_names_uniprotkb": "Hddc3; Mesh1", "gene_names_refseq": "1110033O09Rik; Hddc3; MESH1", "protein_names_uniprotkb": "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; (ppGpp)ase; 3.1.7.2; HD domain-containing protein 3; MESH1; Metazoan SpoT homolog 1; Penta-phosphate guanosine-3'-pyrophosphohydrolase", "protein_names_refseq": "(ppGpp)ase; HD domain-containing protein 3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 1; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; metazoan SpoT homolog 1; penta-phosphate guanosine-3'-pyrophosphohydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:68695)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "ppGpp hydrolyzing enzyme involved in starvation response., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.7.2", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D279-1", "uniprot_id": "MISP_MOUSE", "mass": 72281.0, "length": 648, "protein_name": "Mitotic interactor and substrate of PLK1", "gene_name": "Misp", "organism": "Mouse", "refseq_name": "mitotic interactor and substrate of PLK1", "refseq_ac": "NP_084494", "gene_names_uniprotkb": "Misp", "gene_names_refseq": "9130017N09Rik; Misp", "protein_names_uniprotkb": "Mitotic interactor and substrate of PLK1; Mitotic spindle positioning protein", "protein_names_refseq": "mitotic interactor and substrate of PLK1; mitotic spindle positioning protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78906)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;36596561", "class_list": "", "function": "Mitotic spindle positioning protein (MISP) deficiency exacerbates dextran sulfate sodium (DSS)-induced colitis in mice., [RefSeq, PubMed]; Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytoskeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI04", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0030864 cortical actin cytoskeleton;GO:0031616 spindle pole centrosome", "go_biological_process": "GO:0016477 cell migration;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0030866 cortical actin cytoskeleton organization;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D279-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ39-1", "uniprot_id": "MED21_MOUSE", "mass": 15588.0, "length": 144, "protein_name": "Mediator of RNA polymerase II transcription subunit 21", "gene_name": "Med21", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 21", "refseq_ac": "NP_079591", "gene_names_uniprotkb": "Med21; Srb7; Surb7", "gene_names_refseq": "0610007L03Rik; D6Ertd782e; Med21; Srb7; Surb7", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 21; Mediator complex subunit 21; RNA polymerase II holoenzyme component SRB7; RNAPII complex component SRB7", "protein_names_refseq": "RNA polymerase II holoenzyme component SRB7; RNAPII complex component SRB7; SRB7 (supressor of RNA polymerase B) homolog; mediator of RNA polymerase II transcription subunit 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:108098)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10500093;12037571;21750661;25428506;29845885", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our results revealed a critical, albeit complex role of Pol II pausing control in regulating the temporal output of gene transcription., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921I5", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0061630 ubiquitin protein ligase activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQ39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9F8-1", "uniprot_id": "MIPO1_MOUSE", "mass": 31751.0, "length": 279, "protein_name": "Mirror-image polydactyly gene 1 protein homolog", "gene_name": "Mipol1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mipol1", "gene_names_refseq": "", "protein_names_uniprotkb": "Mirror-image polydactyly gene 1 protein homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "11954550;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D9F8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKP5-1", "uniprot_id": "MBNL1_MOUSE", "mass": 36976.0, "length": 341, "protein_name": "Muscleblind-like protein 1", "gene_name": "Mbnl1", "organism": "Mouse", "refseq_name": "muscleblind-like protein 1 isoform 2", "refseq_ac": "NP_001240637", "gene_names_uniprotkb": "Mbnl1; Exp; Mbnl", "gene_names_refseq": "Mbnl1; Mbnl; mKIAA0428", "protein_names_uniprotkb": "Muscleblind-like protein 1; Triplet-expansion RNA-binding protein", "protein_names_refseq": "muscleblind like splicing factor 1; muscleblind-like 1; muscleblind-like protein 1 isoform 2; muscleblind-like protein 1; triplet-expansion RNA-binding protein", "tax_id": 10090, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonic disease (Disease Ontology:DOID:450); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:56758)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10970838;14671308;21750661;25153642;28528544;34428180;38426339;38473933;39927985;40997131", "class_list": "", "function": "MBNL1 Regulates Programmed Postnatal Switching Between Regenerative and Differentiated Cardiac States., [RefSeq, PubMed]; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs (By similarity). Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (By similarity). Regulates NCOR2 alternative splicing (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results show that disruption of the mouse Mbnl1 gene leads to muscle, eye, and RNA splicing abnormalities that are characteristic of myotonic dystrophy disease, [RefSeq, PubMed]; Studying the Effect of MBNL1 and MBNL2 Loss in Skeletal Muscle Regeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001069 regulatory region RNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007399 nervous system development;GO:0030326 embryonic limb morphogenesis;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JKP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LB6-1", "uniprot_id": "MAT2B_MOUSE", "mass": 37393.0, "length": 334, "protein_name": "Methionine adenosyltransferase 2 subunit beta", "gene_name": "Mat2b", "organism": "Mouse", "refseq_name": "methionine adenosyltransferase 2 subunit beta isoform 2", "refseq_ac": "NP_001186203", "gene_names_uniprotkb": "Mat2b", "gene_names_refseq": "1110064C04Rik; 2410018D16Rik; MAT-II; MATIIbeta; Mat2b; TGR", "protein_names_uniprotkb": "Methionine adenosyltransferase 2 subunit beta; MAT II beta; Methionine adenosyltransferase II beta", "protein_names_refseq": "MAT II beta; methionine adenosyltransferase 2 beta subunit; methionine adenosyltransferase 2 subunit beta isoform 2; methionine adenosyltransferase 2 subunit beta; methionine adenosyltransferase II, beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:108645); (R-MMU-156581); (R-MMU-5689880)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16022199;21750661;29695199;32046373;37507081", "class_list": "", "function": "Increased miR-21-3p in Injured Brain Microvascular Endothelial Cells after Traumatic Brain Injury Aggravates Blood-Brain Barrier Damage by Promoting Cellular Apoptosis and Inflammation through Targeting MAT2B., [RefSeq, PubMed]; Methionine Adenosyltransferase 2beta Participates in Mouse Oocyte Maturation by Regulating the MAPK Pathway., [RefSeq, PubMed]; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NC89;Q76LX2;Q8BVX6;Q8BYT9", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0030234 enzyme regulator activity;GO:0048270 methionine adenosyltransferase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0048269 methionine adenosyltransferase complex", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0006556 S-adenosylmethionine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99LB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N08-1", "uniprot_id": "M4A6C_MOUSE", "mass": 23622.0, "length": 217, "protein_name": "Membrane-spanning 4-domains subfamily A member 6C", "gene_name": "Ms4a6c", "organism": "Mouse", "refseq_name": "membrane-spanning 4-domains subfamily A member 6C isoform 2", "refseq_ac": "NP_001159848", "gene_names_uniprotkb": "Ms4a6c", "gene_names_refseq": "2200009H22Rik; 2210417N07Rik; Ms4a6c", "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 6C", "protein_names_refseq": "membrane-spanning 4-domains subfamily A member 6C isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:73656)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11401424", "class_list": "", "function": "May be involved in signal transduction as a component of a multimeric receptor complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8E1;Q8BVZ4;Q9D7Z9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99N08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPU4-1", "uniprot_id": "MGST3_MOUSE", "mass": 16958.0, "length": 153, "protein_name": "Glutathione S-transferase 3, mitochondrial", "gene_name": "Mgst3", "organism": "Mouse", "refseq_name": "glutathione S-transferase 3, mitochondrial", "refseq_ac": "NP_079845", "gene_names_uniprotkb": "Mgst3", "gene_names_refseq": "2010012L10Rik; 2010306B17Rik; 2700004G04Rik; GST-III; Mgst3", "protein_names_uniprotkb": "Glutathione S-transferase 3, mitochondrial; 1.11.1.-; 2.5.1.-; 4.4.1.20; Glutathione peroxidase MGST3; LTC4 synthase MGST3", "protein_names_refseq": "LTC4 synthase MGST3; glutathione S-transferase 3, mitochondrial; glutathione peroxidase MGST3; microsomal GST-3; microsomal GST-III; microsomal glutathione S-transferase III", "tax_id": 10090, "disease": "", "pathway": " (mmu:66447); (R-MMU-156590); (R-MMU-5423646)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "30084848;33300544;34428180", "class_list": "", "function": "Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids. Catalyzes the Michael addition reaction of reduced glutathione (GSH) to electrophilic eicosanoids to form GSH adducts, as part of detoxification or metabolic shunt processes. Mediates GSH conjugation to leukotriene A4 to form the sulfidopeptide leukotriene C4. Metabolizes cyclopentenone prostanoids, specifically mediates GSH addition at C9 within the cyclopentenone ring of 15-deoxy-Delta12,14-prostaglandin J2 (15dPGJ2) to form 15dPGJ2-glutathione. L-cysteine cannot substitute for GSH. Catalyzes the reduction of eicosanoid peroxides to yield eicosanoid hydroxides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXC5;Q9D834", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.11.1.12;1.11.1.9;2.5.1.-;5.3.99.3", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004464 leukotriene-C4 synthase activity;GO:0042802 identical protein binding;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0019370 leukotriene biosynthetic process;GO:0019369 arachidonate metabolic process;GO:0006692 prostanoid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CPU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ86-1", "uniprot_id": "MIEN1_MOUSE", "mass": 12295.0, "length": 115, "protein_name": "Migration and invasion enhancer 1", "gene_name": "Mien1", "organism": "Mouse", "refseq_name": "migration and invasion enhancer 1", "refseq_ac": "NP_079835", "gene_names_uniprotkb": "Mien1; Rdx12", "gene_names_refseq": "1810046J19Rik; Mien1; Rdx12", "protein_names_uniprotkb": "Migration and invasion enhancer 1", "protein_names_refseq": "migration and invasion enhancer 1; protein C17orf37 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:103742)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17503775;28135057;34428180;38272230", "class_list": "", "function": "Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity)., [UniProtKB]; Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A556", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0051491 positive regulation of filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQ86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQL1-1", "uniprot_id": "MGN2_MOUSE", "mass": 17092.0, "length": 146, "protein_name": "Protein mago nashi homolog 2", "gene_name": "Magohb", "organism": "Mouse", "refseq_name": "protein mago nashi homolog 2 isoform 2", "refseq_ac": "NP_001314789", "gene_names_uniprotkb": "Magohb; Magoh-rs1; Magoh2", "gene_names_refseq": "2010012C16Rik; Magoh-rs1; Magohb; Magoh; Mago", "protein_names_uniprotkb": "Protein mago nashi homolog 2", "protein_names_refseq": "mago nashi protein; mago-nashi homolog B; mago-nashi homolog, proliferation-associated, related sequence 1; protein mago nashi homolog 1-related; protein mago nashi homolog 2 isoform 2; protein mago nashi homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66441); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-975957)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "21750661;23358417;23917022", "class_list": "", "function": "Findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay, [RefSeq, PubMed]; Reexpression of KMT2B was sufficient to reinstate an active MagohB promoter., [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78Y23", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0071013 catalytic step 2 spliceosome;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398 mRNA splicing, via spliceosome;GO:0050684 regulation of mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZ09-1", "uniprot_id": "MET18_MOUSE", "mass": 40448.0, "length": 362, "protein_name": "Histidine protein methyltransferase 1 homolog", "gene_name": "Mettl18", "organism": "Mouse", "refseq_name": "histidine protein methyltransferase 1 homolog", "refseq_ac": "NP_081555", "gene_names_uniprotkb": "Mettl18", "gene_names_refseq": "2810422O20Rik; Mettl18", "protein_names_uniprotkb": "Histidine protein methyltransferase 1 homolog; 2.1.1.85; Methyltransferase-like protein 18", "protein_names_refseq": "histidine protein methyltransferase 1 homolog; methyltransferase-like protein 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:69962)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;35820727", "class_list": "", "function": "Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation. Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810I8", "ec_number_list": "2.1.1.85", "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0018064 protein-L-histidine N-tele-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:2000232 regulation of rRNA processing;GO:0006417 regulation of translation;GO:0006448 regulation of translational elongation;GO:0018026 peptidyl-lysine monomethylation;GO:0090069 regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CZ09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZD0-1", "uniprot_id": "MMAC_MOUSE", "mass": 31648.0, "length": 279, "protein_name": "Cyanocobalamin reductase / alkylcobalamin dealkylase", "gene_name": "Mmachc", "organism": "Mouse", "refseq_name": "cyanocobalamin reductase / alkylcobalamin dealkylase", "refseq_ac": "NP_080238", "gene_names_uniprotkb": "Mmachc", "gene_names_refseq": "1810037K07Rik; CblC; Mmachc", "protein_names_uniprotkb": "Cyanocobalamin reductase / alkylcobalamin dealkylase; 1.16.1.6; 2.5.1.151; Alkylcobalamin:glutathione S-alkyltransferase; CblC; Cyanocobalamin reductase (cyanide-eliminating); MMACHC; Methylmalonic aciduria and homocystinuria type C protein", "protein_names_refseq": "alkylcobalamin:glutathione S-alkyltransferase; cyanocobalamin reductase (cyanide-eliminating); cyanocobalamin reductase / alkylcobalamin dealkylase; methylmalonic aciduria and homocystinuria type C protein homolog", "tax_id": 10090, "disease": "methylmalonic aciduria and homocystinuria type cblC (Disease Ontology:DOID:0050715)", "pathway": " (mmu:67096); (R-MMU-9759218)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21536470;21697092;24889031;34147638;35013307", "class_list": "", "function": "Absence of MMACHC in peripheral retinal cells does not lead to an ocular phenotype in mice., [RefSeq, PubMed]; Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle. Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether. The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors. Cysteine and homocysteine cannot substitute for glutathione in this reaction., [UniProtKB, UniProtKB]; During organogenesis Mmachc and Mmadhc may interact in only a subset of cells., [RefSeq, PubMed]; Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8S7", "ec_number_list": "2.1.1.13;1.16.1.8;1.16.1.6;2.5.1.151", "go_molecular_function": "GO:0043295 glutathione binding;GO:0042803 protein homodimerization activity;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity;GO:0032451 demethylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009235 cobalamin metabolic process;GO:0070988 demethylation;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CZD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1H9-1", "uniprot_id": "MFAP4_MOUSE", "mass": 28938.0, "length": 257, "protein_name": "Microfibril-associated glycoprotein 4", "gene_name": "Mfap4", "organism": "Mouse", "refseq_name": "microfibril-associated glycoprotein 4 isoform 1 precursor", "refseq_ac": "NP_001334474", "gene_names_uniprotkb": "Mfap4", "gene_names_refseq": "1110007F23Rik; Mfap4", "protein_names_uniprotkb": "Microfibril-associated glycoprotein 4", "protein_names_refseq": "microfibril-associated glycoprotein 4 isoform 1 precursor; microfibril-associated glycoprotein 4", "tax_id": 10090, "disease": "Smith-Magenis syndrome (Disease Ontology:DOID:0060768)", "pathway": " (mmu:76293); (R-MMU-2129379)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16944957;26033354;30899004;38563153", "class_list": "", "function": "Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance., [UniProtKB, UniProtKB]; MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance Artery Structure, While Ameliorating Hypertension., [RefSeq, PubMed]; Mfap4 knockout mice develop a spontaneous loss of lung function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCN1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0001527 microfibril;GO:0071953 elastic fiber", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0007155 cell adhesion;GO:0048251 elastic fiber assembly;GO:0097435 supramolecular fiber organization;GO:0009650 UV protection", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D1H9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D513-1", "uniprot_id": "MEIOB_MOUSE", "mass": 52975.0, "length": 470, "protein_name": "Meiosis-specific with OB domain-containing protein", "gene_name": "Meiob", "organism": "Mouse", "refseq_name": "meiosis-specific with OB domain-containing protein", "refseq_ac": "NP_083473", "gene_names_uniprotkb": "Meiob", "gene_names_refseq": "4930528F23Rik; MLZ-675; Meiob", "protein_names_uniprotkb": "Meiosis-specific with OB domain-containing protein; 3.1.-.-; MLZ-675; Protein expressed in male leptotene and zygotene spermatocytes 675", "protein_names_refseq": "meiosis-specific with OB domain-containing protein; protein expressed in male leptotene and zygotene spermatocytes 675", "tax_id": 10090, "disease": "spermatogenic failure 22 (Disease Ontology:DOID:0070177); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:75178)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "20339383;21750661;24068956;24240703;25428506;28453612;32345962;32463099;33166385", "class_list": "", "function": "Aspartic acid 383 (D383) in MEIOB is essential for meiosis in mice. Isocotoin, a small molecule, inhibits the MEIOB-SPATA22 interaction and promotes their degradation in HEK293 cells in a dose-dependent manner., [RefSeq, PubMed]; MEIOB is required for meiotic recombination and chromosomal synapsis. GeneRIF: MEIOB is a meiosis-specific paralogue of RPA1. MEIOB colocalizes with RPA in foci on meiotic chromosomes. MEIOB binds to single-stranded DNA and exhibits 3'-5' exonuclease activity. MEIOB forms a complex with RPA and with SPATA22. Chromatin localization and stability of MEIOB depends on SPATA22 and vice versa. MEIOB is essential for meiotic recombination in both sexes., [RefSeq, PubMed]; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro., [UniProtKB, PubMed, PubMed, PubMed]; The ssDNA-binding protein MEIOB acts as a dosage-sensitive regulator of meiotic recombination. GeneRIF: Two mutations (N64I and S67 deletion) in MEIOB cause self-aggregation of MEIOB and sharply reduced protein half-life. In addition to a role in early meiotic recombination, MEIOB/SPATA22 plays a role in late meiotic recombination, i.e., in crossover formation, in a dosage-dependent manner., [RefSeq, PubMed]; We find that MEIOB and SPATA22 form an obligate complex and contain defined interaction domains GeneRIF: MEIOB and SPATA22 form an obligate complex and contain defined interaction domains. A single residue D383 in MEIOB is indispensable for the MEIOB-SPATA22 interaction. The MEIOB/SPATA22 complex interacts with the RPA heterotrimeric complex in a collaborative manner., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLG1", "ec_number_list": "", "go_molecular_function": "GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0003682 chromatin binding;GO:0003697 single-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0007144 female meiosis I;GO:0009566 fertilization;GO:0007140 male meiotic nuclear division;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D513-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7G9-1", "uniprot_id": "MISS_MOUSE", "mass": 27761.0, "length": 263, "protein_name": "MAPK-interacting and spindle-stabilizing protein", "gene_name": "Mapk1ip1", "organism": "Mouse", "refseq_name": "MAPK-interacting and spindle-stabilizing protein", "refseq_ac": "NP_001038948", "gene_names_uniprotkb": "Mapk1ip1; Miss", "gene_names_refseq": "2310009E07Rik; MISS; Mapk1ip1", "protein_names_uniprotkb": "MAPK-interacting and spindle-stabilizing protein; Mitogen-activated protein kinase 1-interacting protein 1", "protein_names_refseq": "MAPK-interacting and spindle-stabilizing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69546)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12011110", "class_list": "", "function": "Involved in the maintenance of the spindle integrity during the cytostatic factor (CSF) arrest of oocytes., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7M749", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D7G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB91-1", "uniprot_id": "MED29_MOUSE", "mass": 21011.0, "length": 199, "protein_name": "Mediator of RNA polymerase II transcription subunit 29", "gene_name": "Med29", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 29", "refseq_ac": "NP_080318", "gene_names_uniprotkb": "Med29; Ixl", "gene_names_refseq": "2810405O22Rik; Ixl; Med29", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 29; Intersex-like protein; Mediator complex subunit 29", "protein_names_refseq": "intersex-like protein; mediator of RNA polymerase II transcription subunit 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:67224)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DB91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DC37-1", "uniprot_id": "MFSD1_MOUSE", "mass": 51396.0, "length": 464, "protein_name": "Lysosomal dipeptide transporter MFSD1", "gene_name": "Mfsd1", "organism": "Mouse", "refseq_name": "lysosomal dipeptide transporter MFSD1", "refseq_ac": "NP_080089", "gene_names_uniprotkb": "Mfsd1", "gene_names_refseq": "1200003O06Rik; Mfsd1", "protein_names_uniprotkb": "Lysosomal dipeptide transporter MFSD1; Major facilitator superfamily domain-containing protein 1", "protein_names_refseq": "lysosomal dipeptide transporter MFSD1; major facilitator superfamily domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66868)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19144319;25428506;27981419;31661432;32959924;35820727;38507452", "class_list": "", "function": "Characterization of the complex of the lysosomal membrane transporter MFSD1 and its accessory subunit GLMP., [RefSeq, PubMed]; Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol (PubMed:38507452). Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion (By similarity). Also essential for liver homeostasis (PubMed:31661432)., [UniProtKB, PubMed, UniProtKB, PubMed]; Mfsd1 knockout mice develop splenomegaly and severe liver disease. Proteomics of isolated lysosomes from Mfsd1 knockout mice revealed GLMP as a critical accessory subunit for MFSD1. MFSD1 and GLMP physically interact. GLMP is essential for the maintenance of normal levels of MFSD1 in lysosomes and vice versa. Publication Status: Online-Only, [RefSeq, PubMed]; Protein expression of MFSD1 is in mouse brain regions is specifically affected by altered nutrient uptake., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWU0;Q8BVZ3", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0160178 dipeptide uniporter activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0061462 protein localization to lysosome;GO:0141204 dipeptide transmembrane transport from lysosomal lumen to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DC37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DD20-1", "uniprot_id": "TMT1B_MOUSE", "mass": 28049.0, "length": 244, "protein_name": "Thiol S-methyltransferase TMT1B", "gene_name": "Tmt1b", "organism": "Mouse", "refseq_name": "thiol S-methyltransferase TMT1B precursor", "refseq_ac": "NP_082129", "gene_names_uniprotkb": "Tmt1b; Mettl7b", "gene_names_refseq": "0610006F02Rik; Mettl7b; Tmt1b", "protein_names_uniprotkb": "Thiol S-methyltransferase TMT1B; 2.1.1.9; Methyltransferase-like protein 7B; Thiol S-methyltransferase METTL7B", "protein_names_refseq": "methyltransferase like 7B; methyltransferase-like protein 7B; thiol S-methyltransferase METTL7B; thiol S-methyltransferase TMT1B precursor; thiol S-methyltransferase TMT1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:71664)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "34428180;35603523;37453647", "class_list": "", "function": "Methyltransferase like 7B is upregulated in sepsis and modulates lipopolysaccharide-induced inflammatory response and macrophage polarization., [RefSeq, PubMed]; Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Selectively methylates S-centered nucleophiles from metabolites such as hydrogen sulfide and dithiothreitol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78ID2", "ec_number_list": "2.1.1.9", "go_molecular_function": "GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0018708 thiol S-methyltransferase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DD20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI70-1", "uniprot_id": "MKKS_MOUSE", "mass": 61924.0, "length": 570, "protein_name": "Molecular chaperone MKKS", "gene_name": "Mkks", "organism": "Mouse", "refseq_name": "molecular chaperone MKKS isoform 1", "refseq_ac": "NP_001135418", "gene_names_uniprotkb": "Mkks; Bbs6", "gene_names_refseq": "1300013E18Rik; Bbs6; Mkks", "protein_names_uniprotkb": "Molecular chaperone MKKS; McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; Protein Bbs6 homolog", "protein_names_refseq": "MKKS protein; McKusick-Kaufman syndrome protein; mcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; molecular chaperone MKKS isoform 1; molecular chaperone MKKS; protein Bbs6 homolog", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); Bardet-Biedl syndrome 6 (Disease Ontology:DOID:0110128); McKusick-Kaufman syndrome (Disease Ontology:DOID:0111255); congenital heart disease (Disease Ontology:DOID:1682); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:59030); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10802661;15731008;15772095;18317593;23671934;28753627;30446775;31219806", "class_list": "", "function": "Loss of Bardet-Biedl Syndrome proteins (BBS) proteins Bbs6 and Bbs8 affects ciliated retinal pigment epithelium (RPE)., [RefSeq, PubMed]; MKKS/BBS6 is a novel centrosomal component required for cytokinesis, [RefSeq, PubMed]; Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (By similarity). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:28753627). May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq, Nov 2013]., [RefSeq]; Three uORFs (uMKKS0, uMKKS1 and uMKKS2) are reported, and they can repress the translation of the downstream MKKS ORF. uMKKS1 and uMKKS2 are highly conserved in mammals and they encode two different mitochondrial membrane proteins respectively., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGQ3", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0031514 motile cilium", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0021766 hippocampus development;GO:0021987 cerebral cortex development;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JI70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXP6-1", "uniprot_id": "MKRN1_MOUSE", "mass": 53008.0, "length": 481, "protein_name": "E3 ubiquitin-protein ligase makorin-1", "gene_name": "Mkrn1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mkrn1", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase makorin-1; 2.3.2.27; RING-type E3 ubiquitin transferase makorin-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:54484); (R-MMU-198323); (R-MMU-8948751); (R-MMU-983168)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10843807;12721631;12968785;12971993;16785614;16882727;21750661", "class_list": "", "function": "E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase (By similarity). Has negative and positive effects on RNA polymerase II-dependent transcription., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;2.7.11.1;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QXP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVS8-1", "uniprot_id": "MK07_MOUSE", "mass": 87733.0, "length": 806, "protein_name": "Mitogen-activated protein kinase 7", "gene_name": "Mapk7", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 7 isoform b", "refseq_ac": "NP_001277962", "gene_names_uniprotkb": "Mapk7; Bmk1; Erk5", "gene_names_refseq": "BMK-1; BMK1; ERK-5; ERK5; Erk5-T; Mapk7; PRKM7; b2b2346Clo", "protein_names_uniprotkb": "Mitogen-activated protein kinase 7; 2.7.11.24; BMK-1; Big MAP kinase 1; ERK-5; Extracellular signal-regulated kinase 5; MAP kinase 7; MAPK 7", "protein_names_refseq": "MAPK 7; big MAP kinase 1; extracellular signal-regulated kinase 5; mitogen-activated protein kinase 7 isoform b", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:23939); (R-MMU-198753); (R-MMU-198765); (R-MMU-202670); (R-MMU-2559582); (R-MMU-881907); (R-MMU-8853659)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "10473620;11139578;11278431;11520859;12093914;15085193;15716121;20724525;21750661;23243209;23428871;31219806;34428180;37307577;38369471", "class_list": "", "function": "Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation., [RefSeq, PubMed]; Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects., [RefSeq, PubMed]; HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2N7;Q3UG52;Q497T0;Q5NCN6;Q5NCN7;Q5NCN9;Q6QLU8;Q9R1D9;Q9WVF3;Q9WVF4", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.1;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.1.3.16;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;3.1.3.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0051019 mitogen-activated protein kinase binding;GO:0004707 MAP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016605 PML body", "go_biological_process": "GO:0070375 ERK5 cascade;GO:0070377 negative regulation of ERK5 cascade;GO:0006468 protein phosphorylation;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9WVS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKL4-1", "uniprot_id": "NDUF3_MOUSE", "mass": 20734.0, "length": 185, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "gene_name": "Ndufaf3", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "refseq_ac": "NP_075736", "gene_names_uniprotkb": "Ndufaf3", "gene_names_refseq": "4733401H18Rik; Ndufaf3", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Protein 2P1", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; nuclear protein E3-3; protein 2P1", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 18 (Disease Ontology:DOID:0112070)", "pathway": " (mmu:66706); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12653254;21750661", "class_list": "", "function": "Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1A3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JKL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P45448-1", "uniprot_id": "NR5A2_MOUSE", "mass": 64020.0, "length": 560, "protein_name": "Nuclear receptor subfamily 5 group A member 2", "gene_name": "Nr5a2", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 5 group A member 2 isoform 1", "refseq_ac": "NP_109601", "gene_names_uniprotkb": "Nr5a2; Ftf; Lrh1", "gene_names_refseq": "D1Ertd308e; Ftf; LRH-1; Nr5a2; UF2-H3B; mFTF", "protein_names_uniprotkb": "Nuclear receptor subfamily 5 group A member 2; Fetoprotein transcription factor; LRH-1; Liver receptor homolog 1; mFTF", "protein_names_refseq": "fetoprotein transcription factor; liver receptor homolog 1; nuclear receptor subfamily 5 group A member 2 isoform 1", "tax_id": 10090, "disease": "colon cancer (Disease Ontology:DOID:219)", "pathway": " (mmu:26424); (R-MMU-383280); (R-MMU-4090294)", "pathway_count": 3, "publication_count": 37, "publication_id_list": "12456679;12482977;12820970;14766742;15014077;15831456;15976031;16923850;17670946;19015525;20096661;21614002;21750661;21852532;24737860;25063451;27447294;27984042;29443959;30084848;30305617;30555544;31328159;33441767;34397088;34428180;35192609;36423263;36905926;37935903;38243114;38386558;38409506;38685137;38804232;38977846;39361745", "class_list": "", "function": "Diabetic Macrophage Exosomal miR-381-3p Inhibits Epithelial Cell Autophagy Via NR5A2., [RefSeq, PubMed]; Nr5a2 is dispensable for zygotic genome activation but essential for morula development., [RefSeq, PubMed]; Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as early embryonic development, cholesterol and bile acid synthesis pathways, as well as liver and pancreas morphogenesis (PubMed:14766742, PubMed:15831456, PubMed:15976031, PubMed:29443959, PubMed:38409506, PubMed:38977846, PubMed:39361745). Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation (PubMed:15976031). The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine can act as ligand in vitro (PubMed:15976031). Acts as a pioneer transcription factor, which unwraps target DNA from histones and elicits local opening of closed chromatin (PubMed:38409506). Plays a central role during preimplantation stages of embryonic development (PubMed:15014077, PubMed:15831456, PubMed:34397088, PubMed:36423263, PubMed:37935903, PubMed:38243114, PubMed:38386558, PubMed:39361745). Plays a minor role in zygotic genome activation (ZGA) by regulating a small set of two-cell stage genes (PubMed:36423263, PubMed:39361745). Plays a major role in morula development (2-16 cells embryos) by acting as a master regulator at the 8-cell stage, controlling expression of lineage-specifying transcription factors and genes involved in mitosis, telomere maintenance and DNA repair (PubMed:37935903, PubMed:38386558, PubMed:39361745). Zygotic NR5A2 binds to both closed and open chromatin with other transcription factors, often at SINE B1/Alu repeats DNA elements, promoting chromatin accessibility at nearby regulatory regions (PubMed:39361745). Also involved in the epiblast stage of development and embryonic stem cell pluripotency, by promoting expression of POU5F1/OCT4 (PubMed:15831456, PubMed:20096661, PubMed:27984042, PubMed:34397088, PubMed:38386558). Regulates other processes later in development, such as formation of connective tissue in lower jaw and middle ear, neural stem cell differentiation, ovarian follicle development and Sertoli cell differentiation (PubMed:27447294, PubMed:33441767, PubMed:35192609, PubMed:36905926). Involved in exocrine pancreas development and acinar cell differentiation (PubMed:21852532, PubMed:25063451, PubMed:29443959). Acts as an essential transcriptional regulator of lipid metabolism (By similarity). Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver (By similarity). Activates the transcription of CYP2C38 (PubMed:30555544). Also acts as a negative regulator of inflammation in different organs, such as intestine, liver and pancreas (PubMed:17670946, PubMed:29443959, PubMed:30305617). Protects against intestinal inflammation via its ability to regulate glucocorticoid production (PubMed:16923850, PubMed:17670946). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity). Acts as a regulator of immunity by promoting lymphocyte T-cell development, proliferation and effector functions (PubMed:31328159). Also involved in resolution of endoplasmic reticulum stress in the liver (PubMed:24737860)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Regulation of Betaine Homocysteine Methyltransferase by Liver Receptor Homolog-1 in the Methionine Cycle., [RefSeq, PubMed]; Role in mediating species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter, [RefSeq, PubMed]; The specificities of LXXLL-related motifs in Dax-1 based on their amino acid sequences play an important role in regulation of orphan receptors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EHF9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005694 chromosome;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0001545 primary ovarian follicle growth;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P45448-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUE4-1", "uniprot_id": "NPRL2_MOUSE", "mass": 43644.0, "length": 380, "protein_name": "GATOR1 complex protein NPRL2", "gene_name": "Nprl2", "organism": "Mouse", "refseq_name": "GATOR1 complex protein NPRL2", "refseq_ac": "NP_061367", "gene_names_uniprotkb": "Nprl2", "gene_names_refseq": "2810446G01Rik; G21; NPR2L; Nprl2; Tusc4", "protein_names_uniprotkb": "GATOR1 complex protein NPRL2; G21 protein; Gene 21 protein; NPR2-like protein; Nitrogen permease regulator 2-like protein", "protein_names_refseq": "GATOR complex protein NPRL2; GATOR1 complex protein NPRL2; NPR2-like protein; gene 21 protein; nitrogen permase homolog; nitrogen permease regulator 2-like protein; nitrogen permease regulator-like 2; tumor suppressor candidate 4", "tax_id": 10090, "disease": "familial focal epilepsy with variable foci 2 (Disease Ontology:DOID:0081422)", "pathway": " (mmu:56032); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;26166573;29768191;30084848;30779550;34083520;34428180;34965576;38006878", "class_list": "", "function": "Catalytic component of the GATOR1 complex, a multiprotein complex that functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:26166573, PubMed:29768191, PubMed:38006878). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity). In the presence of abundant amino acids, the GATOR1 complex is ubiquitinated and inhibited by GATOR2 (By similarity). Within the GATOR1 complex, NPRL2 constitutes the catalytic subunit that mediates the GTPase activator activity and under methionine-sufficient conditions, the GTPase activator activity is inhibited by PRMT1 through methylation and consequently inducing timely mTORC1 activation (PubMed:38006878)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: novel mouse models for GATORopathy., [RefSeq, PubMed]; Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development. Publication Status: Online-Only, [RefSeq, PubMed]; Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0005774 vacuolar membrane;GO:1990130 GATOR1 complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0031669 cellular response to nutrient levels;GO:0045947 negative regulation of translational initiation;GO:0038202 TORC1 signaling;GO:0033673 negative regulation of kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WUE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88425-1", "uniprot_id": "NDK6_MOUSE", "mass": 21778.0, "length": 189, "protein_name": "Nucleoside diphosphate kinase 6, mitochondrial", "gene_name": "Nme6", "organism": "Mouse", "refseq_name": "nucleoside diphosphate kinase 6, mitochondrial isoform 1", "refseq_ac": "NP_061227", "gene_names_uniprotkb": "Nme6", "gene_names_refseq": "NDK 6; NDK6; Nme6; nm23-M6", "protein_names_uniprotkb": "Nucleoside diphosphate kinase 6, mitochondrial; 2.7.4.6; NDK6; NDP kinase 6; nm23-M6", "protein_names_refseq": "NDP kinase 6; expressed in non-metastatic cells 6, protein (nucleoside diphosphate kinase); nm23/nucleoside diphosphate kinase 6; non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase 6, mitochondrial isoform 1; nucleoside diphosphate kinase 6, mitochondrial; nucleoside diphosphate kinase 6; nucleoside diphosphate kinase type 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:54369); (R-MMU-499943)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10453732;21750661;22899353;31219806", "class_list": "", "function": "Catalytic subunit of a complex with RCC1L, which catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving the formation of a phosphohistidine intermediate. Participates in the regulation of mitochondrial nucleotide levels, mitoribosome biogenesis, and mitochondrial RNA abundances. Supplies pyrimidine ribonucleoside triphosphates (rNTPs) for mitochondrial transcription and is required for the maintenance of mitochondrial DNA (mtDNA) when the import of pyrimidine deoxyribonucleoside triphosphates (dNTPs) is limited from the cytosol is limited. As a monomer, lacks nucleoside diphosphate kinase (NDPK) activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nme6 or Nme7 can regulate several critical processes in embryonic stem cell renewal., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99M53", "ec_number_list": "2.7.4.6;2.7.4.4;3.1.11.-;2.7.11.1;2.7.13.3;2.7.4.18;3.1.24.-;2.7.4.3;2.7.4.14", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0030308 negative regulation of cell growth;GO:0045839 negative regulation of mitotic nuclear division;GO:0006183 GTP biosynthetic process;GO:0006228 UTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88425-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6B966-1", "uniprot_id": "NAL14_MOUSE", "mass": 113386.0, "length": 993, "protein_name": "NACHT, LRR and PYD domains-containing protein 14", "gene_name": "Nlrp14", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 14", "refseq_ac": "NP_001002894", "gene_names_uniprotkb": "Nlrp14; Nalp14", "gene_names_refseq": "4921520L01Rik; GC-LRR; Nalp-iota; Nalp14l; Nalp14; Nlrp14", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 14; Germ cell specific leucine-rich repeat NTPase; NALP-iota", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 14; NACHT, leucine rich repeat and PYD containing 14; RNI-like protein; germ-cell specific leucine rich repeat NTPase", "tax_id": 10090, "disease": "", "pathway": " (mmu:76858)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15317747;15590904;21750661;25428506;34418053;37493331", "class_list": "", "function": "May be involved in inflammation and spermatogenesis., [UniProtKB]; NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition., [RefSeq, PubMed]; Nalp14 transcripts were continuously expressed through the preovulatory stage, but declined when meiotic maturation resumed, and they were markedly diminished by the 2-cell embryo stage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RUL1;Q66X14", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6B966-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ54-1", "uniprot_id": "NDUC2_MOUSE", "mass": 14164.0, "length": 120, "protein_name": "NADH dehydrogenase [ubiquinone] 1 subunit C2", "gene_name": "Ndufc2", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 subunit C2", "refseq_ac": "NP_077182", "gene_names_uniprotkb": "Ndufc2", "gene_names_refseq": "1810004I06Rik; 2010300P09Rik; G1; Ndufc2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 subunit C2; CI-B14.5b; Complex I-B14.5b; NADH-ubiquinone oxidoreductase subunit B14.5b", "protein_names_refseq": "14.5b subunit of the NADH-ubiquinone dehydrogenase complex; CI-B14.5b; NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2; NADH dehydrogenase [ubiquinone] 1 subunit C2; NADH-ubiquinone oxidoreductase subunit B14.5b; complex I-B14.5b", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); nuclear type mitochondrial complex I deficiency (Disease Ontology:DOID:0112065)", "pathway": " (mmu:68197); (R-MMU-611105); (R-MMU-6798695); (R-MMU-6799198)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "21750661;34428180;36288343;37506315;37507081;38385898;38575788;39927985", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, PubMed]; NDUFC2 deficiency exacerbates endothelial mesenchymal transformation during ischemia-reperfusion via NLRP3., [RefSeq, PubMed]; TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLB2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:2001171 positive regulation of ATP biosynthetic process;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction;GO:0010918 positive regulation of mitochondrial membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CQ54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09043-1", "uniprot_id": "NAPSA_MOUSE", "mass": 45544.0, "length": 419, "protein_name": "Napsin-A", "gene_name": "Napsa", "organism": "Mouse", "refseq_name": "napsin-A precursor", "refseq_ac": "NP_032463", "gene_names_uniprotkb": "Napsa; Kdap; Nap", "gene_names_refseq": "KAP; Kdap; NAP1; Napsa; SNAPA; pronapsin", "protein_names_uniprotkb": "Napsin-A; 3.4.23.-; KAP; KDAP-1; Kidney-derived aspartic protease-like protein", "protein_names_refseq": "KDAP-1; kidney-derived aspartic protease-like protein; napsin-A precursor; napsin-A", "tax_id": 10090, "disease": "", "pathway": " (mmu:16541); (R-MMU-5683826)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11082205;16944957;21750661;31219806;32152506;34428180;36047984;9013890", "class_list": "", "function": "May be involved in processing of pneumocyte surfactant precursors., [UniProtKB]; Notch1 Induces Defective Epithelial Surfactant Processing and Pulmonary Fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.23.-", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0097208 alveolar lamellar body", "go_biological_process": "GO:0006508 proteolysis;GO:0043129 surfactant homeostasis;GO:0033619 membrane protein proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O09043-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35975-1", "uniprot_id": "NAR2B_MOUSE", "mass": 33124.0, "length": 289, "protein_name": "T-cell ecto-ADP-ribosyltransferase 2", "gene_name": "Art2b", "organism": "Mouse", "refseq_name": "T-cell ecto-ADP-ribosyltransferase 2 precursor", "refseq_ac": "NP_064299", "gene_names_uniprotkb": "Art2b; Rt6-2; Rt6.2", "gene_names_refseq": "ART2.2; ARTC2; Art2b; Art; Ly92b; Rt-6; Rt6-2; Rt6", "protein_names_uniprotkb": "T-cell ecto-ADP-ribosyltransferase 2; 2.4.2.31; 3.2.2.5; ADP-ribosyltransferase C2 and C3 toxin-like 2; ARTC2; Mono(ADP-ribosyl)transferase 2B; NAD(+) glycohydrolase; T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2; T-cell differentiation marker Rt6 homolog 2; T-cell mono(ADP-ribosyl)transferase 2", "protein_names_refseq": "ADP-ribosyltransferase C2 and C3 toxin-like 2; NAD(+) glycohydrolase; T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2; T-cell differentiation marker Rt6 homolog 2; T-cell ecto-ADP-ribosyltransferase 2 precursor; T-cell ecto-ADP-ribosyltransferase 2; T-cell mono(ADP-ribosyl)transferase 2; mono(ADP-ribosyl)transferase 2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:11872)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11011142;17928361;21750661;26209623;29508376;34489954;34504490;8811076;9300695", "class_list": "", "function": "A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that shedding of T Cell Ecto-ADP-ribosyltransferase ARTC2.2 alters its substrate profile., [RefSeq, PubMed]; Has both NAD(+) glycohydrolase and ADP-ribosyltransferase activity., [UniProtKB, PubMed, PubMed]; Identification of the Mouse T Cell ADP-Ribosylome Uncovers ARTC2.2 Mediated Regulation of CD73 by ADP-Ribosylation. Publication Status: Online-Only, [RefSeq, PubMed]; This study shows that blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F8VQK8;O35702", "ec_number_list": "3.2.2.5;2.4.2.31;3.2.2.6;2.4.99.20;3.2.2.-;2.4.2.-;2.3.1.-;2.3.1.286", "go_molecular_function": "GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0003953 NAD+ nucleosidase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0019897 extrinsic component of plasma membrane", "go_biological_process": "GO:0019677 NAD+ catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35975-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PIJ4-1", "uniprot_id": "NFRKB_MOUSE", "mass": 138764.0, "length": 1296, "protein_name": "Nuclear factor related to kappa-B-binding protein", "gene_name": "Nfrkb", "organism": "Mouse", "refseq_name": "nuclear factor related to kappa-B-binding protein isoform 1", "refseq_ac": "NP_766354", "gene_names_uniprotkb": "Nfrkb", "gene_names_refseq": "A530090G11Rik; Nfrkb", "protein_names_uniprotkb": "Nuclear factor related to kappa-B-binding protein; DNA-binding protein R kappa-B", "protein_names_refseq": "DNA-binding protein R kappa-B; nuclear factor related to kappa-B-binding protein isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:235134); (R-MMU-5689603); (R-MMU-5696394)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "10.3389/fragi.2021.757801;15340146;21183079;21606357;21750661;22517741;22645316;23443134;25428506;29187734;29237092;30059200;30084848;31616917;32782141;32848054;34678516;35820727;35822049;36084651;36852467;39627609;40021952;40885482;40997131", "class_list": "", "function": "Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'., [UniProtKB]; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 28, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 28, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 28, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 30, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWV5;Q8K0X6", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031011 Ino80 complex", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "Q6PIJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ76-1", "uniprot_id": "NEPN_MOUSE", "mass": 57705.0, "length": 512, "protein_name": "Nephrocan", "gene_name": "Nepn", "organism": "Mouse", "refseq_name": "nephrocan precursor", "refseq_ac": "NP_079960", "gene_names_uniprotkb": "Nepn", "gene_names_refseq": "5730521E12Rik; Nepn; Npn; periolin", "protein_names_uniprotkb": "Nephrocan", "protein_names_refseq": "nephrocan precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66650)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16990280;17683524;21750661;25428506", "class_list": "", "function": "May inhibit TGF-beta signaling., [UniProtKB, PubMed]; NPN is a novel member of the SLRP family that may play important roles in kidney development and pathophysiology by functioning as an endogenous inhibitor of TGF-beta signaling, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005614 interstitial matrix", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030198 extracellular matrix organization;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQ76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58058-1", "uniprot_id": "NADK_MOUSE", "mass": 48597.0, "length": 439, "protein_name": "NAD kinase", "gene_name": "Nadk", "organism": "Mouse", "refseq_name": "NAD kinase isoform 1", "refseq_ac": "NP_001153109", "gene_names_uniprotkb": "Nadk", "gene_names_refseq": "4432404C02Rik; Nadk", "protein_names_uniprotkb": "NAD kinase; 2.7.1.23; Poly(P)/ATP NAD kinase", "protein_names_refseq": "NAD kinase isoform 1; Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); poly(P)/ATP NAD kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:192185); (R-MMU-196807)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17242355;21750661;30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCP7", "ec_number_list": "2.7.1.23", "go_molecular_function": "GO:0003951 NAD+ kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006741 NADP+ biosynthetic process;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0019674 NAD+ metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P58058-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C7U1-1", "uniprot_id": "N4BP3_MOUSE", "mass": 60042.0, "length": 537, "protein_name": "NEDD4-binding protein 3", "gene_name": "N4bp3", "organism": "Mouse", "refseq_name": "NEDD4-binding protein 3", "refseq_ac": "NP_666086", "gene_names_uniprotkb": "N4bp3", "gene_names_refseq": "C330016O10Rik; N4bp3", "protein_names_uniprotkb": "NEDD4-binding protein 3; N4BP3", "protein_names_refseq": "NEDD4-binding protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:212706)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (By similarity). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AA64;Q3TDC7;Q3URT6;Q7TNR2;Q922W0;Q99J06", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030424 axon;GO:0030425 dendrite;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007399 nervous system development;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C7U1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGN5-1", "uniprot_id": "NPAL3_MOUSE", "mass": 44808.0, "length": 410, "protein_name": "NIPA-like protein 3", "gene_name": "Nipal3", "organism": "Mouse", "refseq_name": "NIPA-like protein 3 isoform 2", "refseq_ac": "NP_083271", "gene_names_uniprotkb": "Nipal3; Npal3", "gene_names_refseq": "9130020G22Rik; Nipal3; Npal3", "protein_names_uniprotkb": "NIPA-like protein 3", "protein_names_refseq": "NIPA-like protein 3 isoform 2; NIPA-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74552); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19738379;21750661;34428180", "class_list": "", "function": "Disruption of the Npal3 gene results in a pleiotropic phenotype; The function of the nervous system was impaired in both mutant males and females which could be demonstrated in behavioral tests and the the immune system is also affected. Erratum:[Cytogenet Genome Res. 2009;125(4):285. Hoelter, S M [corrected to Holter, S M]; Aguilar, A [corrected to Aguilar-Pimentel, A]; Gailus-Durne, V [corrected to Gailus-Durner, V]; Busch, D [corrected to Busch, D H]], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PG85;Q9D2Y2", "ec_number_list": "", "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015693 magnesium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AIL4-1", "uniprot_id": "NDUF6_MOUSE", "mass": 38362.0, "length": 333, "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "gene_name": "Ndufaf6", "organism": "Mouse", "refseq_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor", "refseq_ac": "NP_001078962", "gene_names_uniprotkb": "Ndufaf6", "gene_names_refseq": "2310030N02Rik; Ndufaf6", "protein_names_uniprotkb": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; UPF0551 protein C8orf38 homolog, mitochondrial", "tax_id": 10090, "disease": "Fanconi renotubular syndrome 5 (Disease Ontology:DOID:0080761); nuclear type mitochondrial complex I deficiency 17 (Disease Ontology:DOID:0112078); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:76947); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18614015;37507081", "class_list": "", "function": "Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of complex I subunit MT-ND1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2AIL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64322-1", "uniprot_id": "NPDC1_MOUSE", "mass": 35720.0, "length": 332, "protein_name": "Neural proliferation differentiation and control protein 1", "gene_name": "Npdc1", "organism": "Mouse", "refseq_name": "neural proliferation differentiation and control protein 1 isoform 1 precursor", "refseq_ac": "NP_032747", "gene_names_uniprotkb": "Npdc1; Npdc-1", "gene_names_refseq": "NPDC-1; Npdc1", "protein_names_uniprotkb": "Neural proliferation differentiation and control protein 1; NPDC-1", "protein_names_refseq": "neural proliferation differentiation and control protein 1 isoform 1 precursor; neural proliferation differentiation and control protein 1; neural proliferation differentiation control-1 protein; neural proliferation, differentiation and control gene 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18146); (R-MMU-198933)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15563841;21750661;22645316;32544377;7878019;7903403", "class_list": "", "function": "MiR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1., [RefSeq, PubMed]; Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation., [UniProtKB]; Upstream sequence of the mouse NPDC-1 gene delineated two regions involved in its negative and positive transcriptional regulation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99J69", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64322-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1H6-1", "uniprot_id": "NDUF4_MOUSE", "mass": 20082.0, "length": 173, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4", "gene_name": "Ndufaf4", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4", "refseq_ac": "NP_081018", "gene_names_uniprotkb": "Ndufaf4; Hrpap20", "gene_names_refseq": "1110007M04Rik; 3000003G13Rik; Ndufaf4", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Hormone-regulated proliferation-associated protein of 20 kDa homolog", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; hormone-regulated proliferation-associated protein of 20 kDa homolog", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 15 (Disease Ontology:DOID:0112077)", "pathway": " (mmu:68493); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;34428180;35820727", "class_list": "", "function": "May be involved in cell proliferation and survival of hormone-dependent tumor cells. Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV72", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0051607 defense response to virus;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0010257 NADH dehydrogenase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D1H6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2APY7-1", "uniprot_id": "NDUF5_MOUSE", "mass": 38405.0, "length": 343, "protein_name": "Arginine-hydroxylase NDUFAF5, mitochondrial", "gene_name": "Ndufaf5", "organism": "Mouse", "refseq_name": "arginine-hydroxylase NDUFAF5, mitochondrial precursor", "refseq_ac": "NP_081369", "gene_names_uniprotkb": "Ndufaf5", "gene_names_refseq": "2310003L22Rik; Ndufaf5", "protein_names_uniprotkb": "Arginine-hydroxylase NDUFAF5, mitochondrial; 1.-.-.-; 2.1.1.-; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5; Putative methyltransferase NDUFAF5", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5; arginine-hydroxylase NDUFAF5, mitochondrial precursor; arginine-hydroxylase NDUFAF5, mitochondrial; probable methyltransferase C20orf7 homolog, mitochondrial; putative methyltransferase NDUFAF5", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 16 (Disease Ontology:DOID:0112096)", "pathway": " (mmu:69487); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Arginine hydroxylase that mediates hydroxylation of 'Arg-122' of NDUFS7 and is involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. May also have methyltransferase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7L6", "ec_number_list": "2.1.1.-;1.-.-.-;7.1.1.2;1.3.8.7;1.3.8.8;2.1.1.320", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0099617 matrix side of mitochondrial inner membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2APY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZP8-1", "uniprot_id": "NPSR1_MOUSE", "mass": 42439.0, "length": 371, "protein_name": "Neuropeptide S receptor", "gene_name": "Npsr1", "organism": "Mouse", "refseq_name": "neuropeptide S receptor", "refseq_ac": "NP_783609", "gene_names_uniprotkb": "Npsr1; Gpr154; Pgr14", "gene_names_refseq": "9330128H10Rik; GPRA; Gpr154; MVTR; Npsr1; PGR14; VRR1", "protein_names_uniprotkb": "Neuropeptide S receptor; G protein-coupled receptor 154; G protein-coupled receptor PGR14", "protein_names_refseq": "G protein-coupled receptor 154; G protein-coupled receptor PGR14; neuropeptide S receptor; vasotocin receptor", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); childhood-onset asthma (Disease Ontology:DOID:0080815); nocturnal asthma (Disease Ontology:DOID:0080826); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); sleep disorder (Disease Ontology:DOID:535); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:319239); (R-MMU-375276); (R-MMU-416476); (R-MMU-418555)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12679517;15073379;16829631;16891776;20171785;21750661;31619542;39332092", "class_list": "", "function": "G protein-coupled receptor for neuropeptide S (NPS) (PubMed:31619542). Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade. Inhibits cell growth in response to NPS binding., [UniProtKB, UniProtKB, PubMed]; GPRA may contribute to the asthmatic phenotype by altering the activity of other pathways, such as neurally mediated mechanisms, that contribute to disease, [RefSeq, PubMed]; NPSR1 is essential in mediating NPS effects on behavior., [RefSeq, PubMed]; NPSR1 promotes chronic colitis through regulating CD4[+] T cell effector function in inflammatory bowel disease., [RefSeq, PubMed]; The isolation and characterization of an arginine vasotocin receptor in mice is reported., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80T64;Q8BYA1", "ec_number_list": "", "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:2000293 negative regulation of defecation;GO:0007218 neuropeptide signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0042755 eating behavior", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BZP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97369-1", "uniprot_id": "NCF4_MOUSE", "mass": 38707.0, "length": 339, "protein_name": "Neutrophil cytosol factor 4", "gene_name": "Ncf4", "organism": "Mouse", "refseq_name": "neutrophil cytosol factor 4 isoform 1", "refseq_ac": "NP_032703", "gene_names_uniprotkb": "Ncf4", "gene_names_refseq": "Ncf4; p40phox", "protein_names_uniprotkb": "Neutrophil cytosol factor 4; NCF-4; Neutrophil NADPH oxidase factor 4; p40-phox; p40phox", "protein_names_refseq": "NCF-4; neutrophil NADPH oxidase factor 4; neutrophil cytosol factor 4 isoform 1; neutrophil cytosol factor 4; p40-phox", "tax_id": 10090, "disease": "autosomal recessive chronic granulomatous disease 3 (Disease Ontology:DOID:0070194); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:17972); (R-MMU-1222556); (R-MMU-1236973); (R-MMU-3299685); (R-MMU-4420097); (R-MMU-5668599); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "20861461;21551061;21750661;34428180;36095971;38547647;8995189;9490028", "class_list": "", "function": "NCF4 dependent intracellular reactive oxygen species regulate plasma cell formation. Erratum:[Redox Biol. 2022 Nov;57:102499. doi: 10.1016/j.redox.2022.102499. PMID: 36243565], [RefSeq, PubMed]; NCF4 regulates antigen presentation of cysteine peptides by intracellular oxidative response and restricts activation of autoreactive and arthritogenic T cells., [RefSeq, PubMed]; Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (By similarity). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBC6", "ec_number_list": "", "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0016176 superoxide-generating NADPH oxidase activator activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006909 phagocytosis;GO:0045730 respiratory burst;GO:0042554 superoxide anion generation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P97369-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG17-1", "uniprot_id": "NOL12_MOUSE", "mass": 25356.0, "length": 217, "protein_name": "Nucleolar protein 12", "gene_name": "Nol12", "organism": "Mouse", "refseq_name": "nucleolar protein 12 isoform 1", "refseq_ac": "NP_598561", "gene_names_uniprotkb": "Nol12; Nop25", "gene_names_refseq": "Nol12; Nop25", "protein_names_uniprotkb": "Nucleolar protein 12; Nucleolar protein of 25 kDa", "protein_names_refseq": "25 kDa nucleolar protein; nucleolar protein 12 isoform 1; nucleolar protein of 25 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:97961)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16430885;17984325;21750661", "class_list": "", "function": "Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RRP17 is a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VI1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0019843 rRNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BG17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C3VPR6-1", "uniprot_id": "NLRC5_MOUSE", "mass": 211710.0, "length": 1915, "protein_name": "Protein NLRC5", "gene_name": "Nlrc5", "organism": "Mouse", "refseq_name": "protein NLRC5", "refseq_ac": "NP_001028379", "gene_names_uniprotkb": "Nlrc5", "gene_names_refseq": "NOD27; Nlrc5", "protein_names_uniprotkb": "Protein NLRC5", "protein_names_refseq": "protein NLRC5", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:434341); (R-MMU-9758274)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "20434986;20610642;21148033;21750661;25428507;25605945;31219806;34428180;35820727;36210013;38878777;40885482", "class_list": "", "function": "NLRC5 expression is critical for lipopolysaccharide-induced interleukin (IL)-10 production in RAW264.7 macrophages., [RefSeq, PubMed]; NLRC5 overexpression promotes interleukin (IL)-1beta production via caspase-1 and is dispensable for cytokine induction in virus and bacterial infections under physiologic conditions., [RefSeq, PubMed]; NLRC5 senses NAD[+] depletion, forming a PANoptosome and driving PANoptosis and inflammation., [RefSeq, PubMed]; Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Study identifies NLRC5 as a negative regulator that blocks two central components of the NF-kappaB and type I interferon signaling pathways and suggest an important role for NLRC5 in homeostatic control of innate immunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q571H9", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus;GO:0009617 response to bacterium;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "C3VPR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCS9-1", "uniprot_id": "NDUBA_MOUSE", "mass": 21024.0, "length": 176, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10", "gene_name": "Ndufb10", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10", "refseq_ac": "NP_080960", "gene_names_uniprotkb": "Ndufb10", "gene_names_refseq": "0610011B04Rik; 22kDa; Ndufb10; PDSW", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; CI-PDSW; Complex I-PDSW; NADH-ubiquinone oxidoreductase PDSW subunit", "protein_names_refseq": "CI-PDSW; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; NADH-ubiquinone oxidoreductase PDSW subunit; complex I-PDSW", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 35 (Disease Ontology:DOID:0112139)", "pathway": " (mmu:68342); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "21183079;21750661;22645316;34428180;36288343;37453647;37507081;38575788;39927985;40021952", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]; Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAE3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9DCS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2VWQ2-1", "uniprot_id": "NELL1_MOUSE", "mass": 89415.0, "length": 810, "protein_name": "Protein kinase C-binding protein NELL1", "gene_name": "Nell1", "organism": "Mouse", "refseq_name": "protein kinase C-binding protein NELL1 precursor", "refseq_ac": "NP_001032995", "gene_names_uniprotkb": "Nell1", "gene_names_refseq": "B230343H07Rik; Nell1; l7R6", "protein_names_uniprotkb": "Protein kinase C-binding protein NELL1; NEL-like protein 1", "protein_names_refseq": "NEL-like protein 1; protein kinase C-binding protein NELL1 precursor; protein kinase C-binding protein NELL1", "tax_id": 10090, "disease": "craniosynostosis (Disease Ontology:DOID:2340)", "pathway": " (mmu:338352)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16537572;16936265;21750661;22517741;26586761;30899004;32848054;38908089;40885482", "class_list": "", "function": "Nell-1 reduced osterix-producing cells and increased bone sialoprotein, osteocalcin, and BMP-7 expression., [RefSeq, PubMed]; Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects GeneRIF: A recessive, neonatal-lethal point mutation in the Nell1 gene causes cranial and skeletal defects., [RefSeq, PubMed]; Neural epidermal growth factor-like 1 protein (Nell-1) alleviates periodontal tissue destruction in periodontitis by regulating the ratio of M2/M1 macrophage phenotypes., [RefSeq, PubMed]; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0030501 positive regulation of bone mineralization;GO:0045669 positive regulation of osteoblast differentiation;GO:0042177 negative regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q2VWQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0Q4-1", "uniprot_id": "NEK11_MOUSE", "mass": 71648.0, "length": 628, "protein_name": "Serine/threonine-protein kinase Nek11", "gene_name": "Nek11", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Nek11", "refseq_ac": "NP_766049", "gene_names_uniprotkb": "Nek11", "gene_names_refseq": "4932416N14Rik; Nek11", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek11; 2.7.11.1; Never in mitosis A-related kinase 11; NimA-related protein kinase 11", "protein_names_refseq": "NIMA-related kinase 11; never in mitosis A-related kinase 11; nimA-related protein kinase 11; serine/threonine-protein kinase Nek11", "tax_id": 10090, "disease": "", "pathway": " (mmu:208583); (R-MMU-69601)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNC3;Q8BLS6;Q8BW62", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;3.1.3.48;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:1901990 regulation of mitotic cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C0Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35684-1", "uniprot_id": "NEUS_MOUSE", "mass": 46348.0, "length": 410, "protein_name": "Neuroserpin", "gene_name": "Serpini1", "organism": "Mouse", "refseq_name": "neuroserpin isoform 1 precursor", "refseq_ac": "NP_033276", "gene_names_uniprotkb": "Serpini1; Pi12; Spi17", "gene_names_refseq": "Ns; PI-12; PI12; Serpini1; Spi17", "protein_names_uniprotkb": "Neuroserpin; PI-12; Peptidase inhibitor 12; Serine protease inhibitor 17; Serpin I1", "protein_names_refseq": "neuroserpin isoform 1 precursor; peptidase inhibitor 12; protease inhibitor 17; serine protease inhibitor 17; serpin I1", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (mmu:20713)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11557034;16075062;17040209;21750661;30899004;34428180;35122213;35820727;9364046;9729122", "class_list": "", "function": "Compartmentalized Actions of the Plasminogen Activator Inhibitors, PAI-1 and Nsp, in Ischemic Stroke., [RefSeq, PubMed]; Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:11557034, PubMed:9364046). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q543F7;Q922U6", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034774 secretory granule lumen;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0060205 cytoplasmic vesicle lumen", "go_biological_process": "GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O35684-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UIJ9-1", "uniprot_id": "MYZAP_MOUSE", "mass": 53897.0, "length": 466, "protein_name": "Myocardial zonula adherens protein", "gene_name": "Myzap", "organism": "Mouse", "refseq_name": "myocardial zonula adherens protein precursor", "refseq_ac": "NP_001028380", "gene_names_uniprotkb": "Myzap; Myozap", "gene_names_refseq": "Gcom1; Gm20502; Gm640; Grinl1a7; Myozap; Myzap", "protein_names_uniprotkb": "Myocardial zonula adherens protein", "protein_names_refseq": "GRINL1A complex locus protein 1; myocardial zonula adherens protein precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:102371)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18849881;20093627;21750661;24698889;30084848;34428180", "class_list": "", "function": "Cardiac overexpression of Myozap results in cardiomyopathy with hypertrophy and left ventricular dilation., [RefSeq, PubMed]; Plays a role in cellular signaling via Rho-related GTP-binding proteins and activation of transcription factor SRF. Targets TJP1 to cell junctions (By similarity). In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity)., [UniProtKB, PubMed]; Reveal myozap as a previously unrecognized component of a Rho-dependent signaling pathway that links the intercalated disc to cardiac gene regulation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RT00", "ec_number_list": "", "go_molecular_function": "GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005856 cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UIJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61600-1", "uniprot_id": "NAA20_MOUSE", "mass": 20368.0, "length": 178, "protein_name": "N-alpha-acetyltransferase 20", "gene_name": "Naa20", "organism": "Mouse", "refseq_name": "N-alpha-acetyltransferase 20 isoform 1", "refseq_ac": "NP_001135437", "gene_names_uniprotkb": "Naa20; Nat5", "gene_names_refseq": "1500004D14Rik; 2900026I01Rik; D2Ertd186e; Naa20; Nat5", "protein_names_uniprotkb": "N-alpha-acetyltransferase 20; 2.3.1.254; Methionine N-acetyltransferase; N-acetyltransferase 5; N-terminal acetyltransferase B complex catalytic subunit NAA20; N-terminal acetyltransferase B complex catalytic subunit NAT5; NatB catalytic subunit; NatB complex subunit NAT5", "protein_names_refseq": "N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae); N-alpha-acetyltransferase 20 isoform 1; N-terminal acetyltransferase B complex catalytic subunit NAA20; N-terminal acetyltransferase B complex catalytic subunit NAT5; methionine N-acetyltransferase; natB catalytic subunit; natB complex subunit NAT5", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 73 (Disease Ontology:DOID:0081233)", "pathway": " (mmu:67877)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19224205;20145209;20173027;21750661;22101279;34428180;35820727;37827343", "class_list": "", "function": "ARD1 functions as an inhibitor of the mTOR pathway and that dysregulation of the ARD1-TSC2-mTOR axis may contribute to cancer development Publication Status: Online-Only, [RefSeq, PubMed]; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mdm20 is not necessarily co-expressed with Nat5 in the developing mouse brain., [RefSeq, PubMed]; NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14B28;Q4VAC3;Q9D7H8;Q9H0Y4;Q9NQH6;Q9Y6D2", "ec_number_list": "2.3.1.254", "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031416 NatB complex", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0006474 N-terminal protein amino acid acetylation;GO:0018002 N-terminal peptidyl-glutamic acid acetylation;GO:0017190 N-terminal peptidyl-aspartic acid acetylation;GO:0017192 N-terminal peptidyl-glutamine acetylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P61600-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXK8-1", "uniprot_id": "NIP7_MOUSE", "mass": 20452.0, "length": 180, "protein_name": "60S ribosome subunit biogenesis protein NIP7 homolog", "gene_name": "Nip7", "organism": "Mouse", "refseq_name": "60S ribosome subunit biogenesis protein NIP7 homolog isoform 1", "refseq_ac": "NP_079667", "gene_names_uniprotkb": "Nip7", "gene_names_refseq": "1110017C15Rik; 6330509M23Rik; Nip7; PEachy", "protein_names_uniprotkb": "60S ribosome subunit biogenesis protein NIP7 homolog; Nucleolar pre-rRNA processing protein NIP7; PEachy; kDa93", "protein_names_refseq": "60S ribosome subunit biogenesis protein NIP7 homolog isoform 1; 60S ribosome subunit biogenesis protein NIP7 homolog; kDa93; nuclear import 7 homolog; nucleolar pre-rRNA processing protein NIP7", "tax_id": 10090, "disease": "", "pathway": " (mmu:66164); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;22645316", "class_list": "", "function": "Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1B4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0042255 ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CXK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBP0-1", "uniprot_id": "NPT2B_MOUSE", "mass": 76245.0, "length": 697, "protein_name": "Sodium-dependent phosphate transport protein 2B", "gene_name": "Slc34a2", "organism": "Mouse", "refseq_name": "sodium-dependent phosphate transport protein 2B", "refseq_ac": "NP_035532", "gene_names_uniprotkb": "Slc34a2; Npt2b", "gene_names_refseq": "D5Ertd227e; NaPi-2b; Npt2b; Slc34a2", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; NaPi-2b; Sodium-phosphate transport protein 2B; Sodium/phosphate cotransporter 2B; Solute carrier family 34 member 2", "protein_names_refseq": "Na(+)-dependent phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; sodium-dependent phosphate transport protein 2B; sodium-phosphate transport protein 2B; sodium/phosphate cotransporter 2B; solute carrier family 34 member 2; type IIb Na/Picotransporter", "tax_id": 10090, "disease": "pulmonary alveolar microlithiasis (Disease Ontology:DOID:12117)", "pathway": " (mmu:20531); (R-MMU-427589); (R-MMU-5683826)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12773415;15701623;15701624;21750661;25428506;29398136;30084848;34428180;9826740", "class_list": "", "function": "Involved in actively transporting phosphate into cells via Na(+) cotransport., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; NaPi-IIb was the predominantly expressed epithelial isoform of the sodium-inorganic phosphate cotransporter and was markedly overexpressed in the proximal region in the infertile knockout compared to the fertile heterozygous c-ros transgenic mouse, [RefSeq, PubMed]; Nampt/NAD(+) system for Npt2 regulation and cellular shifts to tissues such as the liver play an important role in generating daily oscillation of plasma inorganic phosphate levels., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z290", "ec_number_list": "", "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0019904 protein domain specific binding;GO:0031402 sodium ion binding;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016020 membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0043627 response to estrogen;GO:0006817 phosphate ion transport;GO:0030643 intracellular phosphate ion homeostasis;GO:0044341 sodium-dependent phosphate transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9DBP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1J1-1", "uniprot_id": "NECP2_MOUSE", "mass": 28598.0, "length": 266, "protein_name": "Adaptin ear-binding coat-associated protein 2", "gene_name": "Necap2", "organism": "Mouse", "refseq_name": "adaptin ear-binding coat-associated protein 2", "refseq_ac": "NP_079659", "gene_names_uniprotkb": "Necap2", "gene_names_refseq": "1110005F07Rik; NECAP-2; Necap2", "protein_names_uniprotkb": "Adaptin ear-binding coat-associated protein 2; NECAP endocytosis-associated protein 2; NECAP-2", "protein_names_refseq": "NECAP endocytosis-associated protein 2; adaptin ear-binding coat-associated protein 2; clathrin-coated vesicle coat protein; likely ortholog of H. sapiens adaptin-ear-binding coat-associated protein 2 (NECAP2)", "tax_id": 10090, "disease": "", "pathway": " (mmu:66147); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "14555962;14665628;21183079;21750661", "class_list": "", "function": "Involved in endocytosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1M1;Q9CV41", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005886 plasma membrane;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D1J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL89-1", "uniprot_id": "NINJ2_MOUSE", "mass": 15994.0, "length": 143, "protein_name": "Ninjurin-2", "gene_name": "Ninj2", "organism": "Mouse", "refseq_name": "ninjurin-2 isoform 1", "refseq_ac": "NP_057927", "gene_names_uniprotkb": "Ninj2", "gene_names_refseq": "Ninj2", "protein_names_uniprotkb": "Ninjurin-2; Nerve injury-induced protein 2", "protein_names_refseq": "nerve injury-induced protein 2; ninjurin-2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:29862)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10627596;21750661;34787377;36438492;36504350;36549436;38325550", "class_list": "", "function": "Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors., [RefSeq, PubMed]; Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway., [RefSeq, PubMed]; Its role in unclear. In contrast to NINJ1 paralog, does not mediate plasma membrane rupture (cytolysis) downstream of necroptotic and pyroptotic programmed cell death. While it is able to oligomerize and form filaments, filaments are curved toward the intracellular space, preventing circularization to mediate plasma membrane rupture. May act as a homophilic transmembrane adhesion molecule involved in nerve regeneration. Promotes axonal growth., [UniProtKB, UniProtKB]; NINJ2 deficiency inhibits preadipocyte differentiation and promotes insulin resistance through regulating insulin signaling., [RefSeq, PubMed]; Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Ninjurin 2 Modulates Tumorigenesis, Inflammation, and Metabolism via Pyroptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0042246 tissue regeneration;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JL89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5TIS6-1", "uniprot_id": "NOTO_MOUSE", "mass": 26322.0, "length": 240, "protein_name": "Homeobox protein notochord", "gene_name": "Noto", "organism": "Mouse", "refseq_name": "homeobox protein notochord", "refseq_ac": "NP_001007473", "gene_names_uniprotkb": "Noto; Not", "gene_names_refseq": "Flh; MmNot; Noto; Not; tc", "protein_names_uniprotkb": "Homeobox protein notochord", "protein_names_refseq": "Not homeodomain protein; floating head homolog; homeobox protein notochord; notochord homolog; truncate", "tax_id": 10090, "disease": "", "pathway": " (mmu:384452)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15231714;17884984;18061569;21750661;22357932;27914912", "class_list": "", "function": "Transcription factor that controls node morphogenesis (PubMed:15231714, PubMed:17884984, PubMed:18061569, PubMed:22357932). Acts downstream of both FOXA2 and Brachyury (T) during notochord development (PubMed:15231714). Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function (PubMed:17884984). Plays a role in regulating axial versus paraxial cell fate (PubMed:18061569). Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (PubMed:27914912)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5TIS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UM3-1", "uniprot_id": "NAA15_MOUSE", "mass": 100961.0, "length": 865, "protein_name": "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "gene_name": "Naa15", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Naa15; Narg1; Nat1; Tbdn-1; Tubedown", "gene_names_refseq": "", "protein_names_uniprotkb": "N-alpha-acetyltransferase 15, NatA auxiliary subunit; N-terminal acetyltransferase 1; NMDA receptor-regulated protein 1; Protein tubedown-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 50 (Disease Ontology:DOID:0080233); intellectual disability (Disease Ontology:DOID:1059); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:74838)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10842358;11297529;12145306;12888564;15452080;17242355;18299400;21183079;21750661;22645316;22872234;25153642;25428506;28528544;30084848;30779550;31599954;33649389;34428180;35820727;37507081;39627609", "class_list": "", "function": "Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811Z9;Q9JID5", "ec_number_list": "", "go_molecular_function": "GO:0043022 ribosome binding;GO:0010698 acetyltransferase activator activity;GO:0008080 N-acetyltransferase activity;GO:0016407 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q80UM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8B4-1", "uniprot_id": "NDUAB_MOUSE", "mass": 14982.0, "length": 141, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11", "gene_name": "Ndufa11", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ndufa11", "gene_names_refseq": "", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; CI-B14.7; Complex I-B14.7; NADH-ubiquinone oxidoreductase subunit B14.7", "protein_names_refseq": "", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 14 (Disease Ontology:DOID:0112094); communication disorder (Disease Ontology:DOID:2033)", "pathway": " (mmu:69875); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "21750661;22872234;29915388;31219806;33067417;33514727;33990335;34428180;37531432;38177503;38575788;39395414;39788125", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9D8B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08750-1", "uniprot_id": "NFIL3_MOUSE", "mass": 50943.0, "length": 462, "protein_name": "Nuclear factor interleukin-3-regulated protein", "gene_name": "Nfil3", "organism": "Mouse", "refseq_name": "nuclear factor interleukin-3-regulated protein", "refseq_ac": "NP_059069", "gene_names_uniprotkb": "Nfil3; E4bp4", "gene_names_refseq": "E4BP4; Nfil3", "protein_names_uniprotkb": "Nuclear factor interleukin-3-regulated protein; E4 promoter-binding protein 4; Embryo implantation-related NFIL3/E4BP4-like transcription factor", "protein_names_refseq": "E4 promoter-binding protein 4; embryo implantation-related NFIL3/E4BP4-like transcription factor; nuclear factor interleukin-3-regulated protein", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (mmu:18030)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11316793;12023274;12743120;15087429;17182630;17242355;17274955;29653076;30084848;30555544;31219806;32190943;34428180;39048678;9122243", "class_list": "", "function": "Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites (By similarity). Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells (By similarity). Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death. Represses the transcription of CYP2A5 (PubMed:30555544). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (PubMed:29653076). Required for the development of natural killer cell precursors (PubMed:32190943)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Nuclear factor interleukin 3 and metabolic dysfunction-associated fatty liver disease development. Erratum:[Commun Biol. 2025 Sep 29;8(1):1380. doi: 10.1038/s42003-025-08902-2. PMID: 41023388] Publication Status: Online-Only, [RefSeq, PubMed]; The GATA factors play an important role in transducing the survival signal of IL-3, and one of their cellular targets is E4bp4, [RefSeq, PubMed]; The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses Per1 and Per2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULK2;Q497U0", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O08750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09111-1", "uniprot_id": "NDUBB_MOUSE", "mass": 17444.0, "length": 151, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "gene_name": "Ndufb11", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "refseq_ac": "NP_062308", "gene_names_uniprotkb": "Ndufb11; Np15", "gene_names_refseq": "CI-ESSS; D5Bwg0566e; D5Bwg0577e; NP15.6; Ndufb11; Np15; p15.6", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial; CI-ESSS; Complex I-ESSS; NADH-ubiquinone oxidoreductase ESSS subunit; Neuronal protein 15.6; Np15.6; p15.6", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial; NADH-ubiquinone oxidoreductase ESSS subunit; complex I-ESSS; neuronal protein 15.6; nuclear protein 15.6", "tax_id": 10090, "disease": "linear skin defects with multiple congenital anomalies 3 (Disease Ontology:DOID:0111876); nuclear type mitochondrial complex I deficiency 30 (Disease Ontology:DOID:0112098)", "pathway": " (mmu:104130); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16962385;34203471;34428180;36288343;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]; Study shows that the expression of Ndufb11, a gene encoding the mitochondrial protein NP15.6 is decreased in the course of neuronal differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0001669 acrosomal vesicle;GO:0097228 sperm principal piece", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O09111-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54915-1", "uniprot_id": "NR1I2_MOUSE", "mass": 49567.0, "length": 431, "protein_name": "Nuclear receptor subfamily 1 group I member 2", "gene_name": "Nr1i2", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 1 group I member 2 isoform 2", "refseq_ac": "NP_001091874", "gene_names_uniprotkb": "Nr1i2; Pxr", "gene_names_refseq": "Nr1i2; PXR.1; PXR.2; PXR1; PXR; SXR; mPXR", "protein_names_uniprotkb": "Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PXR; Pregnane X receptor", "protein_names_refseq": "Pregnane X receptor; nuclear receptor subfamily 1 group I member 2 isoform 2; orphan nuclear receptor PXR", "tax_id": 10090, "disease": "cholestasis (Disease Ontology:DOID:13580); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:18171); (R-MMU-383280); (R-MMU-4090294)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12569201;12606758;19297428;28751364;30084848;34428180;35609418;38032737;38428309;38788959;9489701", "class_list": "", "function": "Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites. Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. Target genes include cytochrome P450 enzymes such as CYP3A4 and ATP-binding cassette transporters including ABCB1/MDR1., [UniProtKB, UniProtKB]; Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2alpha (PGF2alpha) levels., [RefSeq, PubMed]; Pregnane X receptor knockout mitigates weight gain and hepatic metabolic dysregulation in female C57BL/6 J mice on a long-term high-fat diet., [RefSeq, PubMed]; S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0005667 transcription regulator complex;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O54915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17981-1", "uniprot_id": "NAR2A_MOUSE", "mass": 32801.0, "length": 287, "protein_name": "T-cell ecto-ADP-ribosyltransferase 1", "gene_name": "Art2a", "organism": "Mouse", "refseq_name": "T-cell ecto-ADP-ribosyltransferase 1 precursor", "refseq_ac": "NP_031516", "gene_names_uniprotkb": "Art2a; Art2a-ps; Rt6-1; Rt6.1", "gene_names_refseq": "ARTC2; Art2a-ps; Art2a; Ly92a; Rt-6; Rt6-1; Rt6", "protein_names_uniprotkb": "T-cell ecto-ADP-ribosyltransferase 1; 2.4.2.31; 3.2.2.5; ADP-ribosyltransferase 2a pseudogene; ADP-ribosyltransferase C2 and C3 toxin-like 2; ARTC2; Mono(ADP-ribosyl)transferase 2A; NAD(+) glycohydrolase; T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1; T-cell differentiation marker Rt6 homolog 1; T-cell mono(ADP-ribosyl)transferase 1", "protein_names_refseq": "ADP-ribosyltransferase 2a, pseudogene; ADP-ribosyltransferase C2 and C3 toxin-like 2; NAD(+) glycohydrolase; T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1; T-cell differentiation marker Rt6 homolog 1; T-cell ecto-ADP-ribosyltransferase 1 precursor; T-cell ecto-ADP-ribosyltransferase 1; T-cell mono(ADP-ribosyl)transferase 1; mono(ADP-ribosyl)transferase 2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:11871)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11011142;22781627;2362814;7547715;9300695", "class_list": "", "function": "Has both ADP-ribosyltransferase activity and thiol-dependent NAD(+) glycohydrolase activity., [UniProtKB, PubMed, PubMed]; NAD induces calcium elevation and astrocyte death by an ART2 and P2X7-mediated mechanism., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35278;Q0VB79;Q64173", "ec_number_list": "3.2.2.5;2.4.2.31;3.2.2.6;2.4.99.20;3.2.2.-;2.4.2.-;2.3.1.-;2.3.1.286", "go_molecular_function": "GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0003953 NAD+ nucleosidase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0019677 NAD+ catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P17981-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35454-1", "uniprot_id": "NEU1_MOUSE", "mass": 12851.0, "length": 125, "protein_name": "Oxytocin-neurophysin 1", "gene_name": "Oxt", "organism": "Mouse", "refseq_name": "oxytocin-neurophysin 1 preproprotein", "refseq_ac": "NP_035155", "gene_names_uniprotkb": "Oxt", "gene_names_refseq": "OT; Oxt; Oxy", "protein_names_uniprotkb": "Oxytocin-neurophysin 1; OT-NPI; Ocytocin; pro-OXT; pro-oxytocin/neurophysin", "protein_names_refseq": "OT-NPI; oxytocin-neurophysin 1 preproprotein; oxytocin-neurophysin 1", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); alcohol use disorder (Disease Ontology:DOID:1574); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (mmu:18429); (R-MMU-388479); (R-MMU-416476)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10888874;11471062;16537524;17467653;19369205;2176709;25303526;25874674;26375004;27641503;28963257;30944474;31843930;34381215;37730989;38267576;40267134;40934325;8876199;8933362;9562574;9751758", "class_list": "", "function": "Carrier protein that binds to and transports oxytocin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release., [UniProtKB, UniProtKB]; Neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:10888874, PubMed:25303526, PubMed:25874674, PubMed:26375004, PubMed:27641503, PubMed:28963257, PubMed:30944474, PubMed:34381215, PubMed:37730989, PubMed:38267576, PubMed:40934325, PubMed:8876199, PubMed:8933362). Released in response to a variety of social cues and acts by binding to oxytocin receptor (OXTR), triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:25303526, PubMed:25874674, PubMed:26375004, PubMed:27641503, PubMed:28963257, PubMed:30944474, PubMed:37730989, PubMed:38267576). Central release (direct secretion in the brain) plays essential roles in social behavior, such as maternal care, female mating behavior, social cognition and affiliative behaviors (PubMed:16537524, PubMed:25303526, PubMed:25874674, PubMed:26375004, PubMed:27641503, PubMed:28963257, PubMed:30944474, PubMed:34381215, PubMed:37730989, PubMed:38267576, PubMed:40267134, PubMed:40934325). Stressful and anxiogenic stimuli promote release of oxytocin, which acts as a powerful modulator of anxiety- and stress-related behaviors (By similarity). Modulates neural circuits related to reward, fear and social approach, encouraging care and cooperation, but can also increase guilt or aggression towards out-groups (By similarity). Beyond its role in social behavior, plays a role in other processes, such as parturition, lactation or osteoblast differentiation, when released peripherally (secreted from the posterior pituitary gland into the bloodstream) (PubMed:19369205, PubMed:31843930, PubMed:8876199, PubMed:8933362). Required for parturition and milk ejection by triggering and strengthening contraction of the smooth muscle of the uterus and mammary gland, respectively (By similarity). Promotes bone mass by stimulating bone formation by osteoblasts (PubMed:19369205, PubMed:31843930)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Precursor of oxytocin, a neurohypophyseal hormone that plays a key role in social interactions and neurophysin 1, its carrier protein., [UniProtKB, PubMed]; This gene encodes a preproprotein that is processed to produce oxytocin and neurophysin 1. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin 1. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation, the stress response and complex sexual and maternal behavior, as well as in the regulation of water excretion, salt appetite, blood pressure and cardiovascular functions. Deletion of this gene in mouse reduces bone formation resulting in osteoporosis. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005185 neurohypophyseal hormone activity;GO:0031855 oxytocin receptor binding;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030141 secretory granule", "go_biological_process": "GO:0060179 male mating behavior;GO:0060406 positive regulation of penile erection;GO:0010701 positive regulation of norepinephrine secretion;GO:0002125 maternal aggressive behavior;GO:0060450 positive regulation of hindgut contraction", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P35454-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48744-1", "uniprot_id": "NDP_MOUSE", "mass": 14700.0, "length": 131, "protein_name": "Norrin", "gene_name": "Ndp", "organism": "Mouse", "refseq_name": "norrin precursor", "refseq_ac": "NP_035013", "gene_names_uniprotkb": "Ndp; Ndph", "gene_names_refseq": "ND; Ndph; Ndp", "protein_names_uniprotkb": "Norrin; Norrie disease protein homolog", "protein_names_refseq": "norrie disease protein homolog; norrin precursor; norrin", "tax_id": 10090, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); Norrie disease (Disease Ontology:DOID:0060844); X-linked exudative vitreoretinopathy 2 (Disease Ontology:DOID:0111413); retinopathy of prematurity (Disease Ontology:DOID:13025)", "pathway": " (mmu:17986)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10452356;15035989;19837033;8789439;8835523", "class_list": "", "function": "Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction., [UniProtKB, PubMed, PubMed]; This gene encodes a secreted protein that acts a ligand for multiple different receptors and participates in both Wnt and Wnt-independant signalling. Its activity is important in vascular development of the eye and inner ear. Mutation of the related gene in humans causes Norrie syndrome. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5CZY6", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0060856 establishment of blood-brain barrier;GO:0000278 mitotic cell cycle;GO:0001525 angiogenesis;GO:0003407 neural retina development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P48744-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60761-1", "uniprot_id": "NEUG_MOUSE", "mass": 7496.0, "length": 78, "protein_name": "Neurogranin", "gene_name": "Nrgn", "organism": "Mouse", "refseq_name": "neurogranin", "refseq_ac": "NP_071312", "gene_names_uniprotkb": "Nrgn", "gene_names_refseq": "0710001B06Rik; NG/RC3; NG; Nrgn; Pss1; RC3", "protein_names_uniprotkb": "Neurogranin; Ng; RC3", "protein_names_refseq": "neurogranin (protein kinase C substrate, RC3); neurogranin; postsynaptic spine 1; protein kinase C substrate", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (mmu:64011)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11016969;23462742;24129315;33300544;33924098;35878428;36072929", "class_list": "", "function": "Neurogranin inhibits calcineurin in murine soleus muscle: Effects of heterozygous knockdown on muscle adaptations to tenotomy and fatigue resistance., [RefSeq, PubMed]; Regulates the affinity of calmodulin for calcium. Involved in synaptic plasticity and spatial learning., [UniProtKB, PubMed]; The effects of neurogranin knockdown on SERCA pump efficiency in soleus muscles of female mice fed a high fat diet. Erratum:[Front Endocrinol (Lausanne). 2022 Sep 21;13:1037434. doi: 10.3389/fendo.2022.1037434. PMID: 36213289] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRN7;Q3TYH4", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0012510 trans-Golgi network transport vesicle membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0008306 associative learning;GO:0035556 intracellular signal transduction;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0021537 telencephalon development;GO:0099170 postsynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P60761-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70660-1", "uniprot_id": "NGN1_MOUSE", "mass": 26300.0, "length": 244, "protein_name": "Neurogenin-1", "gene_name": "Neurog1", "organism": "Mouse", "refseq_name": "neurogenin-1", "refseq_ac": "NP_035026", "gene_names_uniprotkb": "Neurog1; Ath4c; Neurod3; Ngn1; Ngn", "gene_names_refseq": "AKA; Math4C; Neurod3; Neurog1; bHLHa6; ngn1", "protein_names_uniprotkb": "Neurogenin-1; Helix-loop-helix protein mATH-4C; NGN-1; NeuroD3; Neurogenic basic-helix-loop-helix protein; Neurogenic differentiation factor 3; mATH4C", "protein_names_refseq": "NGN-1; helix-loop-helix protein mATH-4C; neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; neurogenic differentiation factor 3; neurogenin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18014)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10648228;14697366;18007592;31219806;8816493;8858147;9108377", "class_list": "", "function": "Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042803 protein homodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0048806 genitalia development;GO:0030432 peristalsis;GO:0031223 auditory behavior;GO:0048634 regulation of muscle organ development;GO:0071626 mastication", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70660-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TKR3-1", "uniprot_id": "NAL4C_MOUSE", "mass": 112674.0, "length": 982, "protein_name": "NACHT, LRR and PYD domains-containing protein 4C", "gene_name": "Nlrp4c", "organism": "Mouse", "refseq_name": "NACHT, LRR and PYD domains-containing protein 4C", "refseq_ac": "NP_113566", "gene_names_uniprotkb": "Nlrp4c; Nalp4c", "gene_names_refseq": "Nalp-alpha; Nalp4c; Nlrp4c; Rnh2", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 4C; NALP-alpha", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 4C; NACHT, leucine rich repeat and PYD containing 4C; VNACHT, leucine rich repeat and PYD containing 4C; ribonuclease/angiogenin inhibitor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:83564); (R-MMU-3134975); (R-MMU-3270619)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15317747;25428506", "class_list": "", "function": "May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66X27", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050727 regulation of inflammatory response;GO:0070936 protein K48-linked ubiquitination;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TKR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UFM5-1", "uniprot_id": "NOM1_MOUSE", "mass": 95960.0, "length": 854, "protein_name": "Nucleolar MIF4G domain-containing protein 1", "gene_name": "Nom1", "organism": "Mouse", "refseq_name": "nucleolar MIF4G domain-containing protein 1", "refseq_ac": "NP_001028629", "gene_names_uniprotkb": "Nom1; Gm1040", "gene_names_refseq": "D5Kng1; Gm1040; Nom1", "protein_names_uniprotkb": "Nucleolar MIF4G domain-containing protein 1; SGD1 homolog", "protein_names_refseq": "SGD1 homolog; nucleolar MIF4G domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:433864)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;21952136;25428506;25428507;25605945;30084848;31219806;34428180", "class_list": "", "function": "Plays a role in targeting PPP1CA to the nucleolus., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QPB9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0048820 hair follicle maturation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UFM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UP44-1", "uniprot_id": "NHLC4_MOUSE", "mass": 14169.0, "length": 136, "protein_name": "NHL-repeat-containing protein 4", "gene_name": "Nhlrc4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nhlrc4", "gene_names_refseq": "", "protein_names_uniprotkb": "NHL-repeat-containing protein 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:621239)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UP44-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UYV9-1", "uniprot_id": "NCBP1_MOUSE", "mass": 91927.0, "length": 790, "protein_name": "Nuclear cap-binding protein subunit 1", "gene_name": "Ncbp1", "organism": "Mouse", "refseq_name": "nuclear cap-binding protein subunit 1 isoform 1", "refseq_ac": "NP_001028373", "gene_names_uniprotkb": "Ncbp1; Cbp80", "gene_names_refseq": "CBP80; Ncbp1", "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 1; 80 kDa nuclear cap-binding protein; CBP80; NCBP 80 kDa subunit", "protein_names_refseq": "80 kDa nuclear cap-binding protein; NCBP 80 kDa subunit; nuclear cap-binding protein subunit 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:433702); (R-MMU-111367); (R-MMU-112382); (R-MMU-113418); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-674695); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72187); (R-MMU-72203); (R-MMU-73856); (R-MMU-77588); (R-MMU-77595); (R-MMU-975956); (R-MMU-975957); (R-MMU-9770562); (R-MMU-9930044)", "pathway_count": 23, "publication_count": 13, "publication_id_list": "10786834;11333016;17242355;19144319;19632182;21183079;22767893;25428506;26382858;28528544;31112734;31219806;34428180", "class_list": "", "function": "Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (By similarity)., [UniProtKB, PubMed, UniProtKB]; Study proposes the existence of an alternative cap-binding complex involving NCBP1 and NCBP3 that plays a key role in mRNA biogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AWH4;Q3TEM1;Q7TNE8", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003729 mRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0016071 mRNA metabolic process;GO:0006406 mRNA export from nucleus;GO:0030307 positive regulation of cell growth;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3UYV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60935-1", "uniprot_id": "NAR1_MOUSE", "mass": 35898.0, "length": 325, "protein_name": "GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1", "gene_name": "Art1", "organism": "Mouse", "refseq_name": "GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform 1 precursor", "refseq_ac": "NP_033840", "gene_names_uniprotkb": "Art1; Art2", "gene_names_refseq": "ADPRT; ARTC1; Art1; Yac-1", "protein_names_uniprotkb": "GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; 2.4.2.31; ADP-ribosyltransferase C2 and C3 toxin-like 1; ARTC1; Mono(ADP-ribosyl)transferase 1; YAC-1", "protein_names_refseq": "ADP-ribosyltransferase C2 and C3 toxin-like 1; GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform 1 precursor; GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; mono(ADP-ribosyl)transferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:11870); (R-MMU-1462054)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "30110646;35798928;38062812;38504172;8704249;8812442;9052744", "class_list": "", "function": "ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Arginine ADP-ribosyltransferase 1 Regulates Glycolysis in Colorectal Cancer via the PI3K/AKT/HIF1alpha Pathway., [RefSeq, PubMed]; Has ADP-ribosyltransferase activity toward GLP1R., [UniProtKB]; High Norepinephrine State Induces Growth of Colorectal Cancer Cells via ADP-Ribosyltransferase 1 in Type 2 Diabetes Mellitus., [RefSeq, PubMed]; Proteomic characterization of the heart and skeletal muscle reveals widespread arginine ADP-ribosylation by the ARTC1 ectoenzyme with hemopexin being its target protein., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P70688", "ec_number_list": "3.2.2.5;2.4.2.31;2.4.2.-;2.3.1.-;2.3.1.286", "go_molecular_function": "GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane;GO:0033017 sarcoplasmic reticulum membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q60935-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61985-1", "uniprot_id": "NF2L1_MOUSE", "mass": 81575.0, "length": 741, "protein_name": "Endoplasmic reticulum membrane sensor NFE2L1", "gene_name": "Nfe2l1", "organism": "Mouse", "refseq_name": "endoplasmic reticulum membrane sensor NFE2L1 isoform 1", "refseq_ac": "NP_001123922", "gene_names_uniprotkb": "Nfe2l1; Nrf1", "gene_names_refseq": "LCR-F1; Lcrf1; NRF1; Nfe2l1; TCF-11; TCF11", "protein_names_uniprotkb": "Endoplasmic reticulum membrane sensor NFE2L1; LCR-F1; Locus control region-factor 1; NF-E2-related factor 1; NFE2-related factor 1; Nuclear factor erythroid 2-related factor 1; Nuclear factor, erythroid derived 2, like 1", "protein_names_refseq": "NF-E2-related factor 1; NFE2-related factor 1; endoplasmic reticulum membrane sensor NFE2L1 isoform 1; endoplasmic reticulum membrane sensor NFE2L1; locus control region-factor 1; nuclear factor erythroid 2-related factor 1", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:18023)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "10601325;11342101;12808106;12968018;15738389;16872277;17510056;17705787;18826952;18990090;20385086;20629635;21536885;21554501;21750661;21911472;21953459;22586274;23144760;23816881;25041126;26268886;26947393;29149604;29941490;31219806;34203471;34428180;36210013;37716088;40128797;7759107;9087432;9501099;9580677", "class_list": "", "function": "CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses (PubMed:10601325, PubMed:11342101, PubMed:16872277, PubMed:21911472, PubMed:23144760, PubMed:23816881, PubMed:29149604). Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response (PubMed:12808106, PubMed:15738389, PubMed:16872277, PubMed:21911472, PubMed:23144760, PubMed:23816881). Activates or represses expression of target genes, depending on the context (PubMed:12808106, PubMed:15738389, PubMed:16872277, PubMed:21911472, PubMed:23144760, PubMed:23816881). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess, such as CD36 (PubMed:29149604). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (PubMed:29149604). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes, such as GCLC, GCLM, GSS, MT1 and MT2 (PubMed:10601325, PubMed:11342101, PubMed:12968018, PubMed:15738389, PubMed:18826952). Plays an essential role during fetal liver hematopoiesis: probably has a protective function against oxidative stress and is involved in lipid homeostasis in the liver (PubMed:12808106, PubMed:15738389, PubMed:18826952, PubMed:22586274, PubMed:9501099). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (PubMed:20385086, PubMed:21536885, PubMed:23816881). Also involved in regulating glucose flux (PubMed:25041126). Together with CEBPB; represses expression of DSPP during odontoblast differentiation (By similarity). In response to ascorbic acid induction, activates expression of SP7/Osterix in osteoblasts (PubMed:17510056)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20385086, PubMed:21536885, PubMed:23816881, PubMed:29149604). Constitutes a precursor of the transcription factor NRF1. Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20385086, PubMed:21536885, PubMed:23816881, PubMed:29149604). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (PubMed:29149604). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (PubMed:29149604). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20385086, PubMed:21536885, PubMed:23816881)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice., [RefSeq, PubMed]; This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that binds the antioxidant response elements (ARE) consensus sequence on promoters and activates their expression., [UniProtKB, PubMed, PubMed]; Transcription factor that binds the extended kappa 3 site of the TNF promoter after Fc gamma RIII stimulation and participates in the induction of this cytokine (PubMed:9580677)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9Q038;O70234", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0021781 glial cell fate commitment;GO:0070417 cellular response to cold;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q61985-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64669-1", "uniprot_id": "NQO1_MOUSE", "mass": 30960.0, "length": 274, "protein_name": "NAD(P)H dehydrogenase [quinone] 1", "gene_name": "Nqo1", "organism": "Mouse", "refseq_name": "NAD(P)H dehydrogenase [quinone] 1", "refseq_ac": "NP_032732", "gene_names_uniprotkb": "Nqo1; Dia4; Nmo1; Nmor1", "gene_names_refseq": "Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Nqo1; Ox-1; Ox1; Qr1", "protein_names_uniprotkb": "NAD(P)H dehydrogenase [quinone] 1; 1.6.5.2; Azoreductase; DT-diaphorase; DTD; Menadione reductase; NAD(P)H:quinone oxidoreductase 1; Phylloquinone reductase; QR1; Quinone reductase 1", "protein_names_refseq": "DT-diaphorase; NAD(P)H dehydrogenase (quinone); NAD(P)H dehydrogenase [quinone] 1; NAD(P)H menadione oxidoreductase 1, dioxin inducible; NAD(P)H:quinone oxidoreductase 1; azoreductase; diaphorase 4 (NADH/NADPH); menadione reductase; phylloquinone reductase; quinone reductase 1", "tax_id": 10090, "disease": "small cell carcinoma (Disease Ontology:DOID:0050685); overactive bladder syndrome (Disease Ontology:DOID:0070355); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); alcoholic hepatitis (Disease Ontology:DOID:12351); leukemia (Disease Ontology:DOID:1240); neurodegenerative disease (Disease Ontology:DOID:1289); cholestasis (Disease Ontology:DOID:13580); prostatitis (Disease Ontology:DOID:14654); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); urinary system cancer (Disease Ontology:DOID:3996); macular degeneration (Disease Ontology:DOID:4448); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); chronic kidney disease (Disease Ontology:DOID:784); lung disease (Disease Ontology:DOID:850); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119); liver benign neoplasm (Disease Ontology:DOID:916); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:18104); (R-MMU-350562)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10706635;36288343;36319062;37507081;37686150;7527260;7704040;8999809", "class_list": "", "function": "Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity) (PubMed:8999809). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model. Publication Status: Online-Only, [RefSeq, PubMed]; Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 34, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.17;1.6.5.2;1.6.5.-;1.1.1.184;1.6.5.10;1.1.1.100", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003955 NAD(P)H dehydrogenase (quinone) activity;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0004784 superoxide dismutase activity;GO:0050136 NADH dehydrogenase (quinone) (non-electrogenic) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response;GO:0043086 negative regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64669-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DIB4-1", "uniprot_id": "NOL4L_MOUSE", "mass": 53912.0, "length": 494, "protein_name": "Nucleolar protein 4-like", "gene_name": "Nol4l", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nol4l", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleolar protein 4-like", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DIB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFD7-1", "uniprot_id": "NAIF1_MOUSE", "mass": 35152.0, "length": 327, "protein_name": "Nuclear apoptosis-inducing factor 1", "gene_name": "Naif1", "organism": "Mouse", "refseq_name": "nuclear apoptosis-inducing factor 1", "refseq_ac": "NP_919316", "gene_names_uniprotkb": "Naif1", "gene_names_refseq": "2310007O20Rik; 4933440H19Rik; Naif1", "protein_names_uniprotkb": "Nuclear apoptosis-inducing factor 1", "protein_names_refseq": "nuclear apoptosis-inducing factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71254)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "37828378", "class_list": "", "function": "Induces apoptosis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ASZ4;Q8CEZ2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030308 negative regulation of cell growth;GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PFD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHI9-1", "uniprot_id": "NIM1_MOUSE", "mass": 49777.0, "length": 436, "protein_name": "Serine/threonine-protein kinase NIM1", "gene_name": "Nim1k", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase NIM1", "refseq_ac": "NP_780747", "gene_names_uniprotkb": "Nim1k; Nim1", "gene_names_refseq": "E130304F04Rik; Nim1k; Nim1", "protein_names_uniprotkb": "Serine/threonine-protein kinase NIM1; 2.7.11.1; NIM1 serine/threonine-protein kinase", "protein_names_refseq": "serine/threonine-protein kinase NIM1", "tax_id": 10090, "disease": "", "pathway": " (mmu:245269)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29187734", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q148V1;Q80XC1;Q8BXQ9", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BHI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZF2-1", "uniprot_id": "NIPA4_MOUSE", "mass": 44059.0, "length": 406, "protein_name": "Magnesium transporter NIPA4", "gene_name": "Nipal4", "organism": "Mouse", "refseq_name": "magnesium transporter NIPA4", "refseq_ac": "NP_766112", "gene_names_uniprotkb": "Nipal4; Ichn; Nipa4", "gene_names_refseq": "9530066K23Rik; Nipal4", "protein_names_uniprotkb": "Magnesium transporter NIPA4; Ichthyin; NIPA-like protein 4; Non-imprinted in Prader-Willi/Angelman syndrome region protein 4 homolog", "protein_names_refseq": "NIPA-like protein 4; ichthyin; magnesium transporter NIPA4; non-imprinted in Prader-Willi/Angelman syndrome region protein 4 homolog", "tax_id": 10090, "disease": "autosomal recessive congenital ichthyosis 6 (Disease Ontology:DOID:0060715); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:214112); (R-MMU-5223345)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18667602;25428506;29174370;34428180;38692573", "class_list": "", "function": "Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Sr(2+) and Fe(2+) but to a much less extent than Mg(2+) (PubMed:18667602). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway (By similarity)., [UniProtKB, PubMed, UniProtKB]; Alteration of epidermal lipid composition as a result of deficiency in the magnesium transporter Nipal4., [RefSeq, PubMed]; NIPAL4 is a putative Mg(2+) transporter, and Mg(2+) concentration in differentiated keratinocytes of Nipal4-KO mice was indeed lower than that of wild-type mice., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A4QPF8", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015693 magnesium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BZF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZL1-2", "uniprot_id": "NEUR4_MOUSE", "mass": 52426.0, "length": 478, "protein_name": "Sialidase-4", "gene_name": "Neu4", "organism": "Mouse", "refseq_name": "sialidase-4 isoform 1", "refseq_ac": "NP_001297698", "gene_names_uniprotkb": "Neu4", "gene_names_refseq": "9330166I04; Neu4", "protein_names_uniprotkb": "Sialidase-4; 3.2.1.18; N-acetyl-alpha-neuraminidase 4; Neuraminidase 4", "protein_names_refseq": "N-acetyl-alpha-neuraminidase 4; neuraminidase 4; sialidase-4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:241159); (R-MMU-4085001); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "14637003;18270209;19506080;20862357;22393058;34686927;39136142", "class_list": "glycogene;glycosylhydrolase", "function": "Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:19506080, PubMed:22393058). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (PubMed:19506080, PubMed:22393058). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (By similarity). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:19506080, PubMed:22393058)., [UniProtKB, PubMed, UniProtKB, PubMed]; Mouse Neu4 plays an important regulatory role in neurite formation, possibly through desialylation of glycoproteins, [RefSeq, PubMed]; Neu4 is a functional component of the ganglioside-metabolizing system, contributing to the postnatal development of the brain and other vital organs., [RefSeq, PubMed]; Neu4 is not the only sialidase contributing to the metabolic bypass in Hexa(-/-) mice. Publication Status: Online-Only, [RefSeq, PubMed]; Sialidase neu4 deficiency is associated with neuroinflammation in mice., [RefSeq, PubMed]; Targeting Neuraminidase 4 Attenuates Kidney Fibrosis in Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NS66", "ec_number_list": "3.2.1.18;3.4.16.5;3.4.16.-;3.2.1.23", "go_molecular_function": "GO:0004308 exo-alpha-sialidase activity", "go_cellular_component": "GO:0019866 organelle inner membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0010977 negative regulation of neuron projection development;GO:0009313 oligosaccharide catabolic process;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BZL1-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCP0-1", "uniprot_id": "NEMF_MOUSE", "mass": 121188.0, "length": 1064, "protein_name": "Ribosome quality control complex subunit NEMF", "gene_name": "Nemf", "organism": "Mouse", "refseq_name": "ribosome quality control complex subunit NEMF", "refseq_ac": "NP_079717", "gene_names_uniprotkb": "Nemf", "gene_names_refseq": "1500011I12Rik; 4933405E14Rik; Nemf; Sdccag1", "protein_names_uniprotkb": "Ribosome quality control complex subunit NEMF; Nuclear export mediator factor", "protein_names_refseq": "nuclear export mediator factor Nemf; ribosome quality control complex subunit NEMF; serologically defined colon cancer antigen 1 homolog", "tax_id": 10090, "disease": "neuromuscular disease (Disease Ontology:DOID:440); neuropathy (Disease Ontology:DOID:870)", "pathway": " (mmu:66244); (R-MMU-9954709)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;25428506;32934225;33406423;34428180", "class_list": "", "function": "Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:33406423). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:33406423). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (By similarity). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (By similarity). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (By similarity). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (By similarity). NEMF may also indirectly play a role in nuclear export (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease. Erratum:[Nat Commun. 2020 Oct 1;11(1):5022. doi: 10.1038/s41467-020-18941-4. PMID: 33004807] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAS9;Q3UF46;Q66JX6;Q8C9R6;Q8CA65;Q8JZT9;Q8R072;Q9CW30;Q9CYB8;Q9D4A9", "ec_number_list": "", "go_molecular_function": "GO:0000049 tRNA binding;GO:0043023 ribosomal large subunit binding;GO:1904678 alpha-aminoacyl-tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:1990112 RQC complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0051168 nuclear export;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process;GO:0042780 tRNA 3'-end processing;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CCP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CES0-1", "uniprot_id": "NAA30_MOUSE", "mass": 39433.0, "length": 364, "protein_name": "N-alpha-acetyltransferase 30", "gene_name": "Naa30", "organism": "Mouse", "refseq_name": "N-alpha-acetyltransferase 30", "refseq_ac": "NP_081768", "gene_names_uniprotkb": "Naa30; Mak3; Nat12", "gene_names_refseq": "4930487N19Rik; 5730533P17Rik; Naa30; Nat12", "protein_names_uniprotkb": "N-alpha-acetyltransferase 30; 2.3.1.256; N-acetyltransferase 12; N-acetyltransferase MAK3 homolog; NatC catalytic subunit", "protein_names_refseq": "N-acetyltransferase 12; N-acetyltransferase MAK3 homolog; N-alpha-acetyltransferase 30; Nalpha acetyltransferase 30; natC catalytic subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:70646)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;23806337;28528544;34428180", "class_list": "", "function": "Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RY23;Q7TN07", "ec_number_list": "2.3.1.258;2.3.1.-;2.3.1.256", "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031417 NatC complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CES0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CJC5-1", "uniprot_id": "NEUL3_MOUSE", "mass": 28040.0, "length": 254, "protein_name": "E3 ubiquitin-protein ligase NEURL3", "gene_name": "Neurl3", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase NEURL3", "refseq_ac": "NP_700457", "gene_names_uniprotkb": "Neurl3; Lincr", "gene_names_refseq": "2010300P06Rik; Lincr; Neurl3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NEURL3; 2.3.2.27; Lung-inducible neuralized-related C3CH4 RING domain protein; Neuralized-like protein 3; RING-type E3 ubiquitin transferase NEURL3", "protein_names_refseq": "E3 ubiquitin-protein ligase LINCR; E3 ubiquitin-protein ligase NEURL3; RING-type E3 ubiquitin transferase NEURL3; lung inducible neuralized-related C3HC4 RING finger; lung-inducible neuralized-related C3CH4 RING domain protein; lung-inducible neuralized-related C3CH4 RING domain-containing protein; lung-inducible neuralized-related C3HC4 RING domain protein; neuralized homolog 3 homolog; neuralized-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:214854)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12169584;15936721;21750661;25904058;26495903;35792897;37230320", "class_list": "", "function": "Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development., [RefSeq, PubMed]; E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:15936721, PubMed:35792897). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897). Plays an essential role in TLR4-mediated activation of MAPK pathways by promoting 'Lys-48'-linked polyubiquitination of the phosphatase DUSP1/MKP1 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; LINCR may exert its effects on distal lung development in this model through activation of the Notch signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BS05", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0045087 innate immune response;GO:0070371 ERK1 and ERK2 cascade;GO:0016567 protein ubiquitination;GO:1901800 positive regulation of proteasomal protein catabolic process;GO:0070086 ubiquitin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CJC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K203-1", "uniprot_id": "NEIL3_MOUSE", "mass": 67416.0, "length": 606, "protein_name": "Endonuclease 8-like 3", "gene_name": "Neil3", "organism": "Mouse", "refseq_name": "endonuclease 8-like 3", "refseq_ac": "NP_666320", "gene_names_uniprotkb": "Neil3", "gene_names_refseq": "Neil3", "protein_names_uniprotkb": "Endonuclease 8-like 3; 3.2.2.-; 4.2.99.18; DNA glycosylase FPG2; DNA glycosylase/AP lyase Neil3; Endonuclease VIII-like 3; Nei-like protein 3", "protein_names_refseq": "DNA glycosylase FPG2; DNA glycosylase/AP lyase Neil3; endonuclease 8-like 3; endonuclease VIII-like 3; nei endonuclease VIII-like 3; nei-like protein 3", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:234258); (R-MMU-110330); (R-MMU-110331)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "16428305;19170771;19426544;20185759;21750661;22065741;22569481;22872234;22959434;23305905;23313161;25428506;30084848;30779550;31219806;34418053;35820727;36155818;36181299;36546838;38522610", "class_list": "", "function": "DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161). No activity on 8-oxoG detected (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161). Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161). In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (PubMed:20185759, PubMed:22065741, PubMed:22569481, PubMed:22959434, PubMed:23305905, PubMed:23313161)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Dissecting gene expression networks in the developing hippocampus through the lens of NEIL3 depletion., [RefSeq, PubMed]; Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model., [RefSeq, PubMed]; NEIL3 is localized in the nuclei; Neil3 mRNA was selectively expressed in thymus, spleen and bone marrow, [RefSeq, PubMed]; NEIL3 is specifically expressed in brain areas where neurogenesis takes place during development and that its expression is tightly regulated both temporally and spatially. NEIL3 seems to be upregulated in tumor tissues compared to normal tissues. Publication Status: Online-Only, [RefSeq, PubMed]; NEIL3 promotes hepatoma epithelial-mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway., [RefSeq, PubMed]; WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4ADY6;Q8CD85;Q8R3P4", "ec_number_list": "4.2.99.18;3.2.2.-;1.14.11.51;1.14.11.-;1.14.11.33;5.6.2.4;2.7.7.7;4.2.99.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0003690 double-stranded DNA binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006284 base-excision repair;GO:0000012 single strand break repair;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8K203-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4Q6-1", "uniprot_id": "NEIL1_MOUSE", "mass": 43586.0, "length": 389, "protein_name": "Endonuclease 8-like 1", "gene_name": "Neil1", "organism": "Mouse", "refseq_name": "endonuclease 8-like 1 isoform 1", "refseq_ac": "NP_082623", "gene_names_uniprotkb": "Neil1; Nei1", "gene_names_refseq": "2810450N13Rik; NEH1; Nei1; Neil1", "protein_names_uniprotkb": "Endonuclease 8-like 1; 3.2.2.-; 4.2.99.18; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Endonuclease VIII-like 1; NEH1; Nei homolog 1; Nei-like protein 1", "protein_names_refseq": "DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; endonuclease 8-like 1 isoform 1; endonuclease 8-like 1; endonuclease VIII-like 1; nei homolog 1; nei-like protein 1", "tax_id": 10090, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:72774); (R-MMU-110328); (R-MMU-110329); (R-MMU-5649702)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "12200441;12536207;12713815;14726482;23434322;34857879;38175757", "class_list": "", "function": "Ability of Neil1 to discriminate between thymine glycol stereoisomers Publication Status: Online-Only, [RefSeq, PubMed]; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC., [UniProtKB, PubMed, PubMed]; NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice. Publication Status: Online-Only, [RefSeq, PubMed]; NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1., [RefSeq, PubMed]; NEIL1 is a back-up glycosylase for NTH1 with unique substrate specificity and tissue-specific expression., [RefSeq, PubMed]; Neil1 is an essential component of base excision repair in mammalian cells; its presence may contribute to the redundant repair capacity observed in Ogg1 -/- and Nth1 -/- mice, [RefSeq, PubMed]; Repression of Neil1 espression by RNA interference, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80V58;Q9CYT9", "ec_number_list": "4.2.99.18;3.2.2.-;1.14.11.51;1.14.11.-;1.14.11.33;5.6.2.4;6.5.1.1;2.7.7.7;4.2.99.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K4Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4V1-1", "uniprot_id": "NFAM1_MOUSE", "mass": 29988.0, "length": 264, "protein_name": "NFAT activation molecule 1", "gene_name": "Nfam1", "organism": "Mouse", "refseq_name": "NFAT activation molecule 1 isoform a precursor", "refseq_ac": "NP_001258340", "gene_names_uniprotkb": "Nfam1; Cnaip", "gene_names_refseq": "4921501M20Rik; Cnaip; Nfam1", "protein_names_uniprotkb": "NFAT activation molecule 1; Calcineurin/NFAT-activating ITAM-containing protein; NFAT-activating protein with ITAM motif 1", "protein_names_refseq": "NFAT activation molecule 1 isoform a precursor; NFAT activation molecule 1; calcineurin/NFAT-activating ITAM-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74039); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15143214;19144319;20173027;21750661;26495903;30084848;34428180;35615580;35984892", "class_list": "", "function": "Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1. Publication Status: Online-Only, [RefSeq, PubMed]; May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF promoters (By similarity). May be involved in the regulation of B-cell, but not T-cell, development., [UniProtKB]; NFAM1 modulates B cell signaling through its immunoreceptor tyrosine-based activation motif, which regulates B cell development, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAX8;Q9D5Z3", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0001819 positive regulation of cytokine production;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R4V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KS2-1", "uniprot_id": "NGRN_MOUSE", "mass": 32447.0, "length": 293, "protein_name": "Neugrin", "gene_name": "Ngrn", "organism": "Mouse", "refseq_name": "neugrin precursor", "refseq_ac": "NP_113552", "gene_names_uniprotkb": "Ngrn; Fi58g", "gene_names_refseq": "Ngrn", "protein_names_uniprotkb": "Neugrin; FI58Gm; Neurite outgrowth-associated protein; m-Neugrin", "protein_names_refseq": "FI58Gm; m-Neugrin; neugrin precursor; neurite outgrowth-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:83485)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11118320", "class_list": "", "function": "Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C401;Q99PU9", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0030154 cell differentiation;GO:0070131 positive regulation of mitochondrial translation;GO:0061668 mitochondrial ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99KS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MH5-1", "uniprot_id": "NDK5_MOUSE", "mass": 24002.0, "length": 211, "protein_name": "Nucleoside diphosphate kinase 5", "gene_name": "Nme5", "organism": "Mouse", "refseq_name": "nucleoside diphosphate kinase 5", "refseq_ac": "NP_542368", "gene_names_uniprotkb": "Nme5; Rsph23", "gene_names_refseq": "1700019D05Rik; NDK5; Nm23-M5; Nme5", "protein_names_uniprotkb": "Nucleoside diphosphate kinase 5; 3.1.11.-; NDK5; Putative 3'-5'-DNA exonuclease NDK5; Radial spoke head protein 23 homolog; nm23-M5", "protein_names_refseq": "3'-5' exonuclease NME5; NDK-H 5; NDP kinase homolog 5; expressed in non-metastatic cells 5; non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase 5; nucleoside diphosphate kinase homolog 5; putative 3'-5'-DNA exonuclease NDK5; radial spoke head protein 23 homolog; rsph23", "tax_id": 10090, "disease": "hydrocephalus (Disease Ontology:DOID:10908); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:75533)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12788088;17971504;19303412;21746835;21750661;32203505;36417862", "class_list": "", "function": "Functions as part of axonemal radial spoke complexes, which play an important part in the motility of sperm and cilia (PubMed:36417862). In vitro, does not display nucleoside diphosphate kinase (NDPK) activity. Exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing (By similarity). Confers protection from cell death mediated by BAX and alters the cellular levels of several antioxidant enzymes, including GPX5 (PubMed:12788088). Might be involved in spermiogenesis by enhancing the ability of late-stage spermatids to eliminate reactive oxygen species (PubMed:12788088)., [UniProtKB, PubMed, PubMed, UniProtKB]; Nm23-M5 gene plays an important role in late spermiogenesis by elevating the ability of late-stage spermatids to eliminate reactive oxygen species, [RefSeq, PubMed]; Nme5 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Results reveal that expression of Nm23-M5 plays a critical role in spermiogenesis by increasing the cellular levels of GPX-5 to eliminate reactive oxygen species, [RefSeq, PubMed]; Situs inversus, hydrocephalus, suppurative rhinosinusitis,and sperm flagellar defects in Nme5 null mice are indicative of defective ciliogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810R1", "ec_number_list": "", "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity", "go_cellular_component": "GO:0001534 radial spoke;GO:0005576 extracellular region;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0060271 cilium assembly;GO:0000302 response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99MH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ49-1", "uniprot_id": "NCBP2_MOUSE", "mass": 18017.0, "length": 156, "protein_name": "Nuclear cap-binding protein subunit 2", "gene_name": "Ncbp2", "organism": "Mouse", "refseq_name": "nuclear cap-binding protein subunit 2", "refseq_ac": "NP_080830", "gene_names_uniprotkb": "Ncbp2; Cbp20", "gene_names_refseq": "20kDa; 5930413E18Rik; Ncbp2", "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 2; 20 kDa nuclear cap-binding protein; CBP20; NCBP 20 kDa subunit", "protein_names_refseq": "20 kDa nuclear cap-binding protein; CBP20; NCBP 20 kDa subunit; nuclear cap binding protein subunit 2, 20kDa; nuclear cap-binding protein subunit 2", "tax_id": 10090, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (mmu:68092); (R-MMU-111367); (R-MMU-112382); (R-MMU-113418); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-674695); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72187); (R-MMU-72203); (R-MMU-73856); (R-MMU-77588); (R-MMU-77595); (R-MMU-975956); (R-MMU-975957); (R-MMU-9770562); (R-MMU-9930044)", "pathway_count": 23, "publication_count": 8, "publication_id_list": "10786834;17242355;19632182;21183079;21750661;24129315;26382858;34428180", "class_list": "", "function": "Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; NCBP2 is not required for cell viability and poly(A) RNA export. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VF93;Q3UI86", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0017069 snRNA binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0036064 ciliary basal body", "go_biological_process": "GO:0046833 positive regulation of RNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQ49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQJ8-1", "uniprot_id": "NDUB9_MOUSE", "mass": 21984.0, "length": 179, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "gene_name": "Ndufb9", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 1", "refseq_ac": "NP_075661", "gene_names_uniprotkb": "Ndufb9", "gene_names_refseq": "1190008J14Rik; CI-B22; Ndufb9", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; CI-B22; Complex I-B22; NADH-ubiquinone oxidoreductase B22 subunit", "protein_names_refseq": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform 1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; NADH-ubiquinone oxidoreductase B22 subunit; complex I-B22", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 24 (Disease Ontology:DOID:0112079)", "pathway": " (mmu:66218); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "34428180;35122619;36288343;37453647;37507081;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]; Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis : Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQS2-1", "uniprot_id": "NOP10_MOUSE", "mass": 7706.0, "length": 64, "protein_name": "H/ACA ribonucleoprotein complex subunit 3", "gene_name": "Nop10", "organism": "Mouse", "refseq_name": "H/ACA ribonucleoprotein complex subunit 3", "refseq_ac": "NP_079679", "gene_names_uniprotkb": "Nop10; Nola3", "gene_names_refseq": "1110036B12Rik; NOP10P; Nola3; Nop10", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit 3; Nucleolar protein 10; Nucleolar protein family A member 3; snoRNP protein NOP10", "protein_names_refseq": "H/ACA ribonucleoprotein complex subunit 3; H/ACA small nucleolar RNPs; NOP10 ribonucleoprotein homolog; nucleolar protein 10; nucleolar protein family A, member 3; snoRNP protein NOP10", "tax_id": 10090, "disease": "autosomal recessive dyskeratosis congenita 1 (Disease Ontology:DOID:0070015); dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (mmu:66181); (R-MMU-171319); (R-MMU-174430)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0034513 box H/ACA snoRNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0016604 nuclear body;GO:0015030 Cajal body;GO:0005697 telomerase holoenzyme complex;GO:0031429 box H/ACA snoRNP complex;GO:0090661 box H/ACA telomerase RNP complex", "go_biological_process": "GO:0031118 rRNA pseudouridine synthesis;GO:0031120 snRNA pseudouridine synthesis;GO:0007004 telomere maintenance via telomerase;GO:0000454 snoRNA guided rRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CQS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQY9-1", "uniprot_id": "NDUC1_MOUSE", "mass": 8625.0, "length": 76, "protein_name": "NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial", "gene_name": "Ndufc1", "organism": "Mouse", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor", "refseq_ac": "NP_079799", "gene_names_uniprotkb": "Ndufc1", "gene_names_refseq": "2310016K22Rik; CI-KFYI; KFYI; Ndufc1", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial; CI-KFYI; Complex I-KFYI; NADH-ubiquinone oxidoreductase KFYI subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial; NADH-ubiquinone oxidoreductase KFYI subunit; complex I-KFYI", "tax_id": 10090, "disease": "", "pathway": " (mmu:66377); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "25605945;34428180;38575788", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58DY9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYQ7-1", "uniprot_id": "NARF_MOUSE", "mass": 51816.0, "length": 462, "protein_name": "Nuclear prelamin A recognition factor", "gene_name": "Narf", "organism": "Mouse", "refseq_name": "nuclear prelamin A recognition factor", "refseq_ac": "NP_080548", "gene_names_uniprotkb": "Narf", "gene_names_refseq": "4430402O11Rik; Narf", "protein_names_uniprotkb": "Nuclear prelamin A recognition factor; IOP2; Iron-only hydrogenase-like protein 2", "protein_names_refseq": "IOP2; iron-only hydrogenase-like protein 2; nuclear prelamin A recognition factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:67608)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "18250455;18299400;20484733;21952136;25428506;25428507;27802388;30084848;30779550;34418053;34428180;35820727;36490339", "class_list": "", "function": "NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVW9", "ec_number_list": "", "go_molecular_function": "GO:0005521 lamin binding", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005638 lamin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9CYQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXL8-1", "uniprot_id": "NDK7_MOUSE", "mass": 44435.0, "length": 395, "protein_name": "Nucleoside diphosphate kinase 7", "gene_name": "Nme7", "organism": "Mouse", "refseq_name": "nucleoside diphosphate kinase 7 isoform 1", "refseq_ac": "NP_001280242", "gene_names_uniprotkb": "Nme7", "gene_names_refseq": "D530024H21Rik; NDK7; Nm23-M7; Nm23-r7; Nme7; nm23-H7", "protein_names_uniprotkb": "Nucleoside diphosphate kinase 7; 2.7.11.1; 3.1.11.-; NDK7; NDP kinase 7; Nm23-M7; Putative 3'-5'-DNA exonuclease NDK7; Serine protein kinase NME7", "protein_names_refseq": "3'-5' exonuclease NME7; NDK 7; NDP kinase 7; NDP kinase homolog 7; non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase 7 isoform 1; nucleoside diphosphate kinase 7; nucleoside diphosphate kinase homolog 7; nucleoside-diphosphate kinase; protein kinase NME7; putative 3'-5'-DNA exonuclease NDK7; serine protein kinase NME7", "tax_id": 10090, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:171567); (R-MMU-380270); (R-MMU-380320)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "20080492;20215702;37295417;37865089;37989994;39824631", "class_list": "", "function": "Possesses an intrinsic kinase activity. Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing. In vitro, does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner (By similarity). May maintain primary cilium assembly and ciliary microtubule stability (PubMed:39824631). Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Situs inversus in Nme7-/- knockout mice GeneRIF: Situs inversus and hydrocephalus observed in Nme7-/- mice, [RefSeq, PubMed]; The nucleoside diphosphate kinase 7 in tracheal epithelia was found in the cell body but not in cilia and directly bind to microtubules., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMG6", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;3.6.5.-;3.6.4.10;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;2.3.1.48;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0010968 regulation of microtubule nucleation;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QXL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1A3-1", "uniprot_id": "NET3_MOUSE", "mass": 62023.0, "length": 580, "protein_name": "Netrin-3", "gene_name": "Ntn3", "organism": "Mouse", "refseq_name": "netrin-3 precursor", "refseq_ac": "NP_035077", "gene_names_uniprotkb": "Ntn3; Ntn2l", "gene_names_refseq": "Ntn2l; Ntn3", "protein_names_uniprotkb": "Netrin-3; Netrin-2-like protein", "protein_names_refseq": "netrin-2-like protein; netrin-3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18209)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10366627;10381568;11231084;12798294;21750661;36587114", "class_list": "", "function": "Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the Intra-epidermal Sprouting of Sensory Axons., [RefSeq, PubMed]; Netrin-3 is expressed by the fetal mucosal epithelium and pancreas., [RefSeq, PubMed]; Netrins control guidance of CNS commissural axons and peripheral motor axons., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9QY49;Q9WVA6", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005604 basement membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0006355 regulation of DNA-templated transcription;GO:0009887 animal organ morphogenesis;GO:0007520 myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9R1A3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WV85-1", "uniprot_id": "NDKC_MOUSE", "mass": 19099.0, "length": 169, "protein_name": "Nucleoside diphosphate kinase C", "gene_name": "Nme3", "organism": "Mouse", "refseq_name": "nucleoside diphosphate kinase C precursor", "refseq_ac": "NP_062704", "gene_names_uniprotkb": "Nme3", "gene_names_refseq": "1810009F08Rik; DR-nm23; NDPK-C; Ndk3; Nm23-DR; Nm23-M3; Nme3", "protein_names_uniprotkb": "Nucleoside diphosphate kinase C; 2.7.4.6; DR-nm23; NDK3; NDPK-C; Nucleoside diphosphate kinase 3; nm23-M3", "protein_names_refseq": "NDK 3; NDP kinase 3; NDPKC; expressed in non-metastatic cells 3; non-metastatic cells 3, protein expressed in; nucleoside diphosphate kinase 3; nucleoside diphosphate kinase C precursor; nucleoside diphosphate kinase C; nucleoside diphosphate kinase DR-nm23", "tax_id": 10090, "disease": "", "pathway": " (mmu:79059); (R-MMU-499943)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12383506;22438820;30111592;34428180;38480688", "class_list": "", "function": "Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:22438820). In vitro, can also use other phosphate donors such as UTP and GTP. Independently of its nucleoside diphosphate kinase activity, involved in mitochondrial membrane tethering, a prerequisite for fusion through direct membrane-binding and hexamerization. Involved in DNA repair of both single- and double-stranded breaks by associating with the ribonucleotide reductase (RNR) complex via interaction with the histone acetyltransferase KAT5, facilitating recruitment to DNA damage sites independently of its kinase activity (By similarity). Inhibits granulocyte differentiation (By similarity). May be required for ciliary function during renal development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; NME3 protein interacts with RHO signaling cascades to impair sperm motility through hyperactivation of SMOK, the wild-type form of the responder., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D931;Q9EPA2", "ec_number_list": "2.7.4.6;2.7.4.4;3.1.11.-;2.7.11.1;2.7.13.3;2.7.4.18;3.1.24.-;2.7.4.3;2.7.4.14", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043531 ADP binding;GO:0019003 GDP binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0036064 ciliary basal body", "go_biological_process": "GO:0006231 dTMP biosynthetic process;GO:0006281 DNA repair;GO:0008053 mitochondrial fusion;GO:0034214 protein hexamerization;GO:0006183 GTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WV85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESG6-1", "uniprot_id": "P2Y14_MOUSE", "mass": 38861.0, "length": 338, "protein_name": "P2Y purinoceptor 14", "gene_name": "P2ry14", "organism": "Mouse", "refseq_name": "P2Y purinoceptor 14 isoform a", "refseq_ac": "NP_001008497", "gene_names_uniprotkb": "P2ry14; Gpr105", "gene_names_refseq": "A330108O13Rik; Gpr105; P2Y14; P2ry14", "protein_names_uniprotkb": "P2Y purinoceptor 14; G protein-coupled receptor 105; P2Y14; UDP-glucose receptor", "protein_names_refseq": "G-protein coupled receptor 105; P2Y purinoceptor 14 isoform a; P2Y purinoceptor 14; UDP-glucose receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:140795); (R-MMU-417957); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21750661;27802388;30084848;30779550;31219806;35432308", "class_list": "", "function": "GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for UDP-glucose coupled to G proteins., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ESG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPV9-1", "uniprot_id": "P2Y12_MOUSE", "mass": 39474.0, "length": 347, "protein_name": "P2Y purinoceptor 12", "gene_name": "P2ry12", "organism": "Mouse", "refseq_name": "P2Y purinoceptor 12", "refseq_ac": "NP_081847", "gene_names_uniprotkb": "P2ry12", "gene_names_refseq": "2900079B22Rik; 4921504D23Rik; P2Y12; P2ry12", "protein_names_uniprotkb": "P2Y purinoceptor 12; P2Y12", "protein_names_refseq": "P2Y purinoceptor 12", "tax_id": 10090, "disease": "peripheral artery disease (Disease Ontology:DOID:0050830); platelet-type bleeding disorder 8 (Disease Ontology:DOID:0060692); thrombosis (Disease Ontology:DOID:0060903); asthma (Disease Ontology:DOID:2841); cerebrovascular disease (Disease Ontology:DOID:6713); abdominal aortic aneurysm (Disease Ontology:DOID:7693); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:70839); (R-MMU-392170); (R-MMU-417957); (R-MMU-418594)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "12897207;15464998;21750661;34428180", "class_list": "", "function": "Receptor for ADP and ATP coupled to G proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation., [UniProtKB, PubMed]; Results describe the cloning of DNA sequences encoding the murine ortholog of the human P2Y12 receptor, and its expression in the mouse brain., [RefSeq, PubMed]; Role of P2Y12 in platelet thrombosis and how its complete absence affects the thrombotic process, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001621 G protein-coupled ADP receptor activity;GO:0001609 G protein-coupled adenosine receptor activity;GO:0045028 G protein-coupled purinergic nucleotide receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0005901 caveola;GO:0009925 basal plasma membrane", "go_biological_process": "GO:1904141 positive regulation of microglial cell migration;GO:1904139 regulation of microglial cell migration;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CPV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8W7-1", "uniprot_id": "OCAD2_MOUSE", "mass": 16926.0, "length": 154, "protein_name": "OCIA domain-containing protein 2", "gene_name": "Ociad2", "organism": "Mouse", "refseq_name": "OCIA domain-containing protein 2 isoform 1", "refseq_ac": "NP_081226", "gene_names_uniprotkb": "Ociad2", "gene_names_refseq": "1810027I20Rik; Ociad2", "protein_names_uniprotkb": "OCIA domain-containing protein 2", "protein_names_refseq": "OCIA domain-containing protein 2 isoform 1; OCIA domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:433904)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23576753;29743632", "class_list": "", "function": "Has an essential role in the assembly of mitochondrial respiratory chain complex III. Is also required for STAT3 activation and plays a role in cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005768 endosome", "go_biological_process": "GO:0016477 cell migration;GO:0009617 response to bacterium;GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D8W7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34986-1", "uniprot_id": "OR6B9_MOUSE", "mass": 35407.0, "length": 316, "protein_name": "Olfactory receptor 6B9", "gene_name": "Or6b9", "organism": "Mouse", "refseq_name": "olfactory receptor 6B9", "refseq_ac": "NP_996780", "gene_names_uniprotkb": "Or6b9; Mor103-16; Olfr6", "gene_names_refseq": "M50; MOR103-16; Olfr6; Or6b9", "protein_names_uniprotkb": "Olfactory receptor 6B9; Odorant receptor M50; Olfactory receptor 103-16; Olfactory receptor 6", "protein_names_refseq": "GA_x6K02T2PBJ9-9337331-9336381; m50 olfactory receptor; odorant receptor M50; olfactory receptor 103-16; olfactory receptor 6B9; olfactory receptor 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:233670)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11130974;11416212;21750661;25428506;7683976", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0PK63;Q9EPG1;Q9EPV0", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P34986-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B9EJ86-1", "uniprot_id": "OSBL8_MOUSE", "mass": 101269.0, "length": 889, "protein_name": "Oxysterol-binding protein-related protein 8", "gene_name": "Osbpl8", "organism": "Mouse", "refseq_name": "oxysterol-binding protein-related protein 8 isoform b", "refseq_ac": "NP_001003717", "gene_names_uniprotkb": "Osbpl8; Kiaa1451; Orp8", "gene_names_refseq": "C730029P18Rik; D330025H14Rik; ORP-8; Osbpl8", "protein_names_uniprotkb": "Oxysterol-binding protein-related protein 8; ORP-8; OSBP-related protein 8", "protein_names_refseq": "OSBP-related protein 8; oxysterol-binding protein-related protein 8 isoform b; oxysterol-binding protein-related protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:237542); (R-MMU-1482801)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17242355;17991739;19144319;20485683;21183079;21750661;23554939;25347070;33300544;39627609;39927985", "class_list": "", "function": "Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the oxysterol-binding protein (Osbp) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal Osbp-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X9N6;Q69ZJ4", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0140343 phosphatidylserine transfer activity;GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0030336 negative regulation of cell migration;GO:0015914 phospholipid transport;GO:0045444 fat cell differentiation;GO:0070328 triglyceride homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "B9EJ86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35383-1", "uniprot_id": "P2RY2_MOUSE", "mass": 42175.0, "length": 373, "protein_name": "P2Y purinoceptor 2", "gene_name": "P2ry2", "organism": "Mouse", "refseq_name": "P2Y purinoceptor 2", "refseq_ac": "NP_001289275", "gene_names_uniprotkb": "P2ry2; P2ru1", "gene_names_refseq": "P2U1; P2Y2; P2ry2", "protein_names_uniprotkb": "P2Y purinoceptor 2; ATP receptor; P2U purinoceptor 1; P2U1; P2Y2; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2U purinoceptor 1; P2Y purinoceptor 2", "tax_id": 10090, "disease": "impotence (Disease Ontology:DOID:1875)", "pathway": " (mmu:18442); (R-MMU-416476); (R-MMU-417957); (R-MMU-5683826); (R-MMU-9856530)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "21750661;38239348;39212624;7685114;7876172;8739319", "class_list": "", "function": "P2Y2-P2X7 receptors cross-talk in primed mesenteric endothelial cells upregulates NF-kappaB signaling favoring mononuclear cell adhesion in schistosomiasis. Publication Status: Online-Only, [RefSeq, PubMed]; Purinergic signaling through the P2Y2 receptor regulates osteocytes' mechanosensitivity., [RefSeq, PubMed]; Receptor for ATP and UTP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O09031;Q9CPZ4", "ec_number_list": "", "go_molecular_function": "GO:0031686 A1 adenosine receptor binding;GO:0045030 G protein-coupled UTP receptor activity;GO:0005524 ATP binding;GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0060406 positive regulation of penile erection;GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35383-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGQ7-1", "uniprot_id": "O5K17_MOUSE", "mass": 36049.0, "length": 317, "protein_name": "Olfactory receptor 5K17", "gene_name": "Or5k17", "organism": "Mouse", "refseq_name": "olfactory receptor 5K17", "refseq_ac": "NP_667210", "gene_names_uniprotkb": "Or5k17; Mor184-4; Olfr181", "gene_names_refseq": "MOR184-4; Olfr181; Or5k17", "protein_names_uniprotkb": "Olfactory receptor 5K17; Olfactory receptor 181; Olfactory receptor 184-4", "protein_names_refseq": "GA_x54KRFPKG5P-55145984-55145034; olfactory receptor 181; olfactory receptor 184-4; olfactory receptor 5K17; olfactory receptor MOR184-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:259001)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKY8;Q05A60;Q7TS47", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TRF3-1", "uniprot_id": "O7D11_MOUSE", "mass": 37660.0, "length": 331, "protein_name": "Olfactory receptor 7D11", "gene_name": "Or7d11", "organism": "Mouse", "refseq_name": "olfactory receptor 7D11", "refseq_ac": "NP_001011748", "gene_names_uniprotkb": "Or7d11; Olfr867", "gene_names_refseq": "MOR143-2; Olfr867; Or7d11", "protein_names_uniprotkb": "Olfactory receptor 7D11; Olfactory receptor 867", "protein_names_refseq": "GA_x6K02T2PVTD-13795933-13794938; olfactory receptor 7D11; olfactory receptor 867; olfactory receptor MOR143-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:257898)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Possible olfactory or taste receptor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TRF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60886-1", "uniprot_id": "OR8B3_MOUSE", "mass": 35358.0, "length": 317, "protein_name": "Olfactory receptor 8B3", "gene_name": "Or8b3", "organism": "Mouse", "refseq_name": "olfactory receptor 8B3", "refseq_ac": "NP_667080", "gene_names_uniprotkb": "Or8b3; Mor164-1; Olfr147; Olfr7", "gene_names_refseq": "M3; MOR164-1; Olfr147; Or8b3", "protein_names_uniprotkb": "Olfactory receptor 8B3; Odorant receptor M3; Olfactory receptor 147; Olfactory receptor 164-1; Olfactory receptor 7E", "protein_names_refseq": "GA_x6K02T2PVTD-32098059-32099003; odorant receptor M3; olfactory receptor 147; olfactory receptor 164-1; olfactory receptor 7E; olfactory receptor 8B3; olfactory receptor MOR164-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258869); (R-MMU-381753)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;31599954;8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TRD2;Q8VGC9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q60886-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922Z0-1", "uniprot_id": "OXDD_MOUSE", "mass": 37546.0, "length": 341, "protein_name": "D-aspartate oxidase", "gene_name": "Ddo", "organism": "Mouse", "refseq_name": "D-aspartate oxidase isoform 2", "refseq_ac": "NP_001303645", "gene_names_uniprotkb": "Ddo", "gene_names_refseq": "5330420D20Rik; 5730402C02Rik; DASPO; Ddo", "protein_names_uniprotkb": "D-aspartate oxidase; 1.4.3.1; DASOX; DASPO; DDO", "protein_names_refseq": "D-aspartate oxidase isoform 2; DASOX", "tax_id": 10090, "disease": "", "pathway": " (mmu:70503); (R-MMU-389661); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 27, "publication_id_list": "16516413;16525061;16725213;17469229;18235994;18314103;20031274;20567862;20603179;21750661;22872234;25689573;25747990;25771393;25979765;26058797;26658710;26707656;26961959;28393897;29292239;30822420;32185508;32553892;35915065;37189369;7903300", "class_list": "", "function": "D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans. Publication Status: Online-Only, [RefSeq, PubMed]; Does not exhibit D-aspartate oxidase activity., [UniProtKB, PubMed]; Prenatal expression of D-aspartate oxidase causes early cerebral D-aspartate depletion and influences brain morphology and cognitive functions at adulthood., [RefSeq, PubMed]; Reports that the behavioral phenotype of the Dco-/- mouse is characterized by deficits in prepulse inhibition of the acoustic startle reflex and in motor coordination on the RotoRod, [RefSeq, PubMed]; Selectively catalyzes the oxidative deamination of acidic amino acids (PubMed:17469229, PubMed:18235994, PubMed:20567862, PubMed:20603179, PubMed:25747990, PubMed:26058797, PubMed:26961959, PubMed:28393897, PubMed:29292239, PubMed:32185508, PubMed:32553892, PubMed:37189369). Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors (PubMed:26961959, PubMed:32185508, PubMed:35915065). Protects the organism from the toxicity of D-amino acids (By similarity). May also function in the intestine (PubMed:35915065)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Selectively catalyzes the oxidative deamination of acidic amino acids., [UniProtKB, PubMed]; Selectively catalyzes the oxidative deamination of acidic amino acids. Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors. Protects the organism from the toxicity of D-amino acids. May also function in the intestine., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E9Q7;Q2UVA9;Q3TT69;Q8R2R2", "ec_number_list": "2.3.2.27;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.1.42;1.5.3.13;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0008445 D-aspartate oxidase activity;GO:0071949 FAD binding;GO:0047821 D-glutamate oxidase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0007320 insemination;GO:0019478 D-amino acid catabolic process;GO:0006533 L-aspartate catabolic process;GO:0050877 nervous system process;GO:0006531 aspartate metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q922Z0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60884-1", "uniprot_id": "O8G17_MOUSE", "mass": 34373.0, "length": 306, "protein_name": "Olfactory receptor 8G17", "gene_name": "Or8g17", "organism": "Mouse", "refseq_name": "olfactory receptor 8G17", "refseq_ac": "NP_666958", "gene_names_uniprotkb": "Or8g17; Mor171-10; Olfr146; Olfr7", "gene_names_refseq": "M15; MOR171-10; Olfr146; Or8g17", "protein_names_uniprotkb": "Olfactory receptor 8G17; Odorant receptor M15; Olfactory receptor 146; Olfactory receptor 171-10; Olfactory receptor 7D", "protein_names_refseq": "GA_x6K02T2PVTD-32715386-32714466; odorant receptor M15; olfactory receptor 146; olfactory receptor 171-10; olfactory receptor 7D; olfactory receptor 8G17; olfactory receptor MOR171-10", "tax_id": 10090, "disease": "", "pathway": " (mmu:258742)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11130974;21750661;8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KMK0;Q9EQ89", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q60884-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60880-1", "uniprot_id": "OL141_MOUSE", "mass": 36673.0, "length": 325, "protein_name": "Olfactory receptor 5T18", "gene_name": "Or5t18", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Or5t18; Olfr141; Olfr4", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor 5T18; Olfactory receptor 141; Olfactory receptor 4B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:257913)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;8570653", "class_list": "", "function": "Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TR61", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60880-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZR4-1", "uniprot_id": "OAF_MOUSE", "mass": 31524.0, "length": 282, "protein_name": "Out at first protein homolog", "gene_name": "Oaf", "organism": "Mouse", "refseq_name": "out at first protein homolog precursor", "refseq_ac": "NP_848759", "gene_names_uniprotkb": "Oaf; D9Ucla1", "gene_names_refseq": "D130038B21Rik; D9Ucla1; Oaf", "protein_names_uniprotkb": "Out at first protein homolog", "protein_names_refseq": "OAF homolog; out at first protein homolog precursor; out at first protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:102644)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD27", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8QZR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C913-1", "uniprot_id": "OCC1_MOUSE", "mass": 6453.0, "length": 63, "protein_name": "Overexpressed in colon carcinoma 1 protein homolog", "gene_name": "1500009L16Rik", "organism": "Mouse", "refseq_name": "overexpressed in colon carcinoma 1 protein homolog", "refseq_ac": "NP_001138670", "gene_names_uniprotkb": "1500009L16Rik", "gene_names_refseq": "1500009L16Rik; 2700050C19Rik; OCC-1", "protein_names_uniprotkb": "Overexpressed in colon carcinoma 1 protein homolog; OCC-1", "protein_names_refseq": "Putative overexpressed in colon carcinoma 1 protein homolog; overexpressed in colon carcinoma 1 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69784)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C913-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D722-1", "uniprot_id": "OSER1_MOUSE", "mass": 32011.0, "length": 291, "protein_name": "Oxidative stress-responsive serine-rich protein 1", "gene_name": "Oser1", "organism": "Mouse", "refseq_name": "oxidative stress-responsive serine-rich protein 1 isoform a", "refseq_ac": "NP_079975", "gene_names_uniprotkb": "Oser1; 3230401D17Rik", "gene_names_refseq": "3230401D17Rik; Oser1; Perit1", "protein_names_uniprotkb": "Oxidative stress-responsive serine-rich protein 1; Oxidative stress-responsive protein 1; Peroxide-inducible transcript 1 protein", "protein_names_refseq": "oxidative stress-responsive protein 1; oxidative stress-responsive serine-rich protein 1 isoform a; oxidative stress-responsive serine-rich protein 1; peroxide-inducible transcript 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66680)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A477;Q3U5N3;Q9CXJ2;Q9D9G1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0070301 cellular response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D722-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUL3-1", "uniprot_id": "PA2GE_MOUSE", "mass": 15943.0, "length": 142, "protein_name": "Group IIE secretory phospholipase A2", "gene_name": "Pla2g2e", "organism": "Mouse", "refseq_name": "group IIE secretory phospholipase A2 precursor", "refseq_ac": "NP_036174", "gene_names_uniprotkb": "Pla2g2e", "gene_names_refseq": "Pla2g2e", "protein_names_uniprotkb": "Group IIE secretory phospholipase A2; 3.1.1.4; GIIE sPLA2; Phosphatidylcholine 2-acylhydrolase 2E; sPLA2-IIE", "protein_names_refseq": "GIIE sPLA2; group IIE secretory phospholipase A2 precursor; group IIE secretory phospholipase A2; mGIIEsPLA2s; phosphatidylcholine 2-acylhydrolase 2E; sPLA2-IIE", "tax_id": 10090, "disease": "", "pathway": " (mmu:26970); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483166)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "10531313;10681567;11922621;21750661;24910243;27226633;37490917", "class_list": "", "function": "PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke., [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:10531313, PubMed:11922621). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), releasing various unsaturated fatty acids including oleoate, linoleoate, arachidonate, docosahexaenoate and lysophosphatidylethanolamines in preference to lysophosphatidylcholines (By similarity). In response to high-fat diet, hydrolyzes minor lipoprotein phospholipids including phosphatidylserines, phosphatidylinositols and phosphatidylglycerols, altering lipoprotein composition and fat storage in adipose tissue and liver (PubMed:24910243). May act in an autocrine and paracrine manner (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (By similarity). Acts as a hair follicle phospholipase A2. Selectively releases lysophosphatidylethanolamines (LPE) and various unsaturated fatty acids in skin to regulate hair follicle homeostasis (PubMed:27226633). May regulate the inflammatory response by releasing arachidonate, a precursor of prostaglandins and leukotrienes. Upon allergen exposure, may participate in allergic inflammatory response by enhancing leukotriene C4 synthesis and degranulation in mast cells (PubMed:11922621)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;3.1.1.5;2.3.1.43;3.1.1.47;3.1.2.2;3.1.1.3;2.3.1.-;3.1.1.-;3.1.1.32;2.3.1.51;3.1.1.23;3.1.-.-", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0016042 lipid catabolic process;GO:0050482 arachidonate secretion;GO:0034374 low-density lipoprotein particle remodeling;GO:0046470 phosphatidylcholine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QUL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UR32-1", "uniprot_id": "P2RX3_MOUSE", "mass": 44437.0, "length": 397, "protein_name": "P2X purinoceptor 3", "gene_name": "P2rx3", "organism": "Mouse", "refseq_name": "P2X purinoceptor 3", "refseq_ac": "NP_663501", "gene_names_uniprotkb": "P2rx3", "gene_names_refseq": "4930513E20Rik; P2X3; P2rx3", "protein_names_uniprotkb": "P2X purinoceptor 3; ATP receptor; P2X3; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2X purinoceptor 3; purinergic receptor P2X3", "tax_id": 10090, "disease": "", "pathway": " (mmu:228139); (R-MMU-139853); (R-MMU-418346)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11069181;11466438;15961431;16322458;21750661;36367795;39227563", "class_list": "", "function": "Extracellular ATP-activated non-selective cation channel (By similarity). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization (PubMed:11069181, PubMed:11466438, PubMed:15961431, PubMed:16322458)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Extracellular ATP-activated non-selective cation channel. Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization., [UniProtKB, UniProtKB]; Finely ordered intracellular domain harbors an allosteric site to modulate physiopathological function of P2X3 receptors. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB, UniProtKB]; The purinergic receptors 2X3 on spiral ganglion neurons enhance the medial olivocochlear reflex in mice after long-term moderate noise exposure., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AW02;Q8R1U4", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043195 terminal bouton;GO:0043197 dendritic spine", "go_biological_process": "GO:0030432 peristalsis;GO:0061368 behavioral response to formalin induced pain;GO:0006811 monoatomic ion transport;GO:0007274 neuromuscular synaptic transmission;GO:0009409 response to cold", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3UR32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3KG59-1", "uniprot_id": "P20D2_MOUSE", "mass": 46482.0, "length": 431, "protein_name": "Xaa-Arg dipeptidase", "gene_name": "Pm20d2", "organism": "Mouse", "refseq_name": "xaa-Arg dipeptidase isoform 2", "refseq_ac": "NP_001030039", "gene_names_uniprotkb": "Pm20d2; Acy1l2; Gm424", "gene_names_refseq": "Acy1l2; Gm424; Pm20d2", "protein_names_uniprotkb": "Xaa-Arg dipeptidase; 3.4.13.4", "protein_names_refseq": "aminoacylase 1-like 2; aminoacylase-1-like protein 2; peptidase M20 domain-containing protein 2; xaa-Arg dipeptidase isoform 2; xaa-Arg dipeptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:242377)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24891507;30084848;31219806;34428180", "class_list": "", "function": "Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. Postulated to function in a metabolite repair mechanism by eliminating alternate dipeptide by-products formed during carnosine synthesis., [UniProtKB, PubMed]; PM20D2 hydrolyzed beta-alanyl-lysine, beta-alanyl-ornithine, gamma-aminobutyryl-lysine, and gamma-aminobutyryl-ornithine as its best substrates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULU7", "ec_number_list": "3.4.13.4", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004180 carboxypeptidase activity;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0051246 regulation of protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A3KG59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGI1-1", "uniprot_id": "O1E16_MOUSE", "mass": 35479.0, "length": 314, "protein_name": "Olfactory receptor 1E16", "gene_name": "Or1e16", "organism": "Mouse", "refseq_name": "olfactory receptor 1E16", "refseq_ac": "NP_667132", "gene_names_uniprotkb": "Or1e16; Mor135-13; Olfr1", "gene_names_refseq": "I54; MOR135-13; Olfr1; Or1e16", "protein_names_uniprotkb": "Olfactory receptor 1E16; Odorant receptor I54; Olfactory receptor 135-13; Olfactory receptor 1", "protein_names_refseq": "GA_x6K02T2P1NL-3556334-3555390; odorant receptor I54; olfactory receptor 135-13; olfactory receptor 1E16; olfactory receptor MOR135-13", "tax_id": 10090, "disease": "", "pathway": " (mmu:258923); (R-MMU-381753)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;8087849", "class_list": "", "function": "Odorant receptor. Activated by a lily-derived aldehyde as well as other odorants. May signal through an inositol 1,4,5-trisphosphate (IP3) second messenger system (By similarity)., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VGI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51576-1", "uniprot_id": "P2RX1_MOUSE", "mass": 44851.0, "length": 399, "protein_name": "P2X purinoceptor 1", "gene_name": "P2rx1", "organism": "Mouse", "refseq_name": "P2X purinoceptor 1", "refseq_ac": "NP_032797", "gene_names_uniprotkb": "P2rx1", "gene_names_refseq": "P2rx1; P2x; Pdcd3; RP-2", "protein_names_uniprotkb": "P2X purinoceptor 1; ATP receptor; P2X1; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2X purinoceptor 1; P2X1 receptor; programmed cell death 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:18436); (R-MMU-139853); (R-MMU-418346); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10638758;11090125;19635923;21750661;25150292;33420030;33603729;36177744;36418376;37046119;8834001", "class_list": "", "function": "ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (By similarity). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (By similarity). Plays a role in male fertility, bladder contraction and platelet aggregation (PubMed:10638758, PubMed:11090125, PubMed:19635923, PubMed:25150292). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (PubMed:10638758). In addition, contributes to smooth muscle contractions of the urinary bladder (PubMed:11090125). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (PubMed:25150292). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; Novel evidence that the P2X1 purinergic receptor-Nlrp3 inflammasome axis orchestrates optimal trafficking of hematopoietic stem progenitors cells., [RefSeq, PubMed]; P2RX1-Involved Glycolytic Metabolism Supports Neutrophil Activation in Acute Pancreatitis. Publication Status: Online-Only, [RefSeq, PubMed]; P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways., [RefSeq, PubMed]; P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway., [RefSeq, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5SRU4", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0044877 protein-containing complex binding;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0002554 serotonin secretion by platelet;GO:0007320 insemination;GO:0003056 regulation of vascular associated smooth muscle contraction;GO:0006811 monoatomic ion transport;GO:0006940 regulation of smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P51576-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51879-1", "uniprot_id": "ONCO_MOUSE", "mass": 12260.0, "length": 109, "protein_name": "Oncomodulin", "gene_name": "Ocm", "organism": "Mouse", "refseq_name": "oncomodulin", "refseq_ac": "NP_149028", "gene_names_uniprotkb": "Ocm", "gene_names_refseq": "Ocm", "protein_names_uniprotkb": "Oncomodulin; OM; Parvalbumin beta", "protein_names_refseq": "OM; oncomodulin; parvalbumin beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:18261)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1468649;21750661;8597631", "class_list": "", "function": "Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions., [UniProtKB]; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62004", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031982 vesicle;GO:0032991 protein-containing complex", "go_biological_process": "GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51879-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UZZ4-1", "uniprot_id": "OLFM4_MOUSE", "mass": 57299.0, "length": 505, "protein_name": "Olfactomedin-4", "gene_name": "Olfm4", "organism": "Mouse", "refseq_name": "olfactomedin-4 precursor", "refseq_ac": "NP_001338876", "gene_names_uniprotkb": "Olfm4", "gene_names_refseq": "GC1; GW112; Gm296; Gm913; OlfD; Olfm4; pPD4", "protein_names_uniprotkb": "Olfactomedin-4; OLM4", "protein_names_refseq": "OLM4; PU.1 difference product 4; olfactomedin-4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:380924); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14962908;20534456;21750661;23161172;39075283", "class_list": "", "function": "A novel PU.1-regulated extracellular glycoprotein of the olfactomedin-like family has a possible role in neutrophilic trafficking.(pdp4), [RefSeq, PubMed]; May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin (By similarity)., [UniProtKB]; OLFM4 exerts considerable influence on the host defense against H. pylori infection acting through NOD1 and NOD2 mediated NF-kappaB activation and subsequent cytokines and chemokines production, which in turn inhibit host immune response., [RefSeq, PubMed]; OLFM4 may function as a tumor suppressor and an anti-metastatic gene during tumor progression, [RefSeq, PubMed]; OLFM4 modulates intestinal inflammation by promoting IL-22[+]ILC3 in the gut. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0045296 cadherin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading;GO:0050777 negative regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UZZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YYU8-1", "uniprot_id": "OBSL1_MOUSE", "mass": 197937.0, "length": 1804, "protein_name": "Obscurin-like protein 1", "gene_name": "Obsl1", "organism": "Mouse", "refseq_name": "obscurin-like protein 1 isoform 1", "refseq_ac": "NP_849215", "gene_names_uniprotkb": "Obsl1", "gene_names_refseq": "Obsl1", "protein_names_uniprotkb": "Obscurin-like protein 1", "protein_names_refseq": "obscurin-like protein 1 isoform 1; obscurin-like protein 1", "tax_id": 10090, "disease": "3-M syndrome (Disease Ontology:DOID:0060241)", "pathway": " (mmu:98733)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31098411", "class_list": "", "function": "Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Skeletal muscle-specific Obsl1 knockouts show a benign phenotype similar to obscurin knockouts. Only deletion of both proteins and removal of their functional redundancy revealed their roles for sarcolemmal stability and sarcoplasmic reticulum organization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F7AD47;Q80WA6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0050775 positive regulation of dendrite morphogenesis;GO:0000226 microtubule cytoskeleton organization;GO:0007088 regulation of mitotic nuclear division;GO:0007030 Golgi organization;GO:0034067 protein localization to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3YYU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TCG5-1", "uniprot_id": "PAQR6_MOUSE", "mass": 38176.0, "length": 343, "protein_name": "Membrane progestin receptor delta", "gene_name": "Paqr6", "organism": "Mouse", "refseq_name": "membrane progestin receptor delta isoform 2", "refseq_ac": "NP_001297526", "gene_names_uniprotkb": "Paqr6", "gene_names_refseq": "1500001B10Rik; Paqr6", "protein_names_uniprotkb": "Membrane progestin receptor delta; Membrane progesterone P4 receptor delta; Membrane progesterone receptor delta; Progesterone and adipoQ receptor family member 6; Progestin and adipoQ receptor family member 6; Progestin and adipoQ receptor family member VI; mPR delta", "protein_names_refseq": "mPR delta; membrane progesterone P4 receptor delta; membrane progesterone receptor delta; membrane progestin receptor delta isoform 2; membrane progestin receptor delta; progesterone and adipoQ receptor family member 6; progestin and adipoQ receptor family member 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:68957)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16044242;21750661;30084848", "class_list": "", "function": "Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. Involved in neurosteroid inhibition of apoptosis. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTT0;Q8CF56", "ec_number_list": "", "go_molecular_function": "GO:0005496 steroid binding;GO:0038023 signaling receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6TCG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDG7-1", "uniprot_id": "PAFA2_MOUSE", "mass": 43562.0, "length": 390, "protein_name": "Platelet-activating factor acetylhydrolase 2, cytoplasmic", "gene_name": "Pafah2", "organism": "Mouse", "refseq_name": "platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b", "refseq_ac": "NP_001272803", "gene_names_uniprotkb": "Pafah2", "gene_names_refseq": "2310074E22Rik; Pafah2", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase 2, cytoplasmic; 2.3.1.149; 3.1.1.47; PAF:lysophospholipid transacetylase; PAF:sphingosine transacetylase; Platelet-activating factor acetyltransferase PAFAH2; SD-PLA2; Serine-dependent phospholipase A2", "protein_names_refseq": "PAF:lysophospholipid transacetylase; PAF:sphingosine transacetylase; SD-PLA2; platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b; platelet-activating factor acetylhydrolase 2, cytoplasmic; platelet-activating factor acetyltransferase PAFAH2; serine-dependent phospholipase A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100163); (R-MMU-418346)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18024956;21750661;30084848;34428180", "class_list": "", "function": "Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (By similarity). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results indicate that PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F(2alpha) and protects tissue from oxidative stress-induced injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNW7;Q8R0Y7", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;2.3.1.43;3.1.1.4;3.1.2.2;3.1.1.3;2.3.1.-;2.3.1.149;3.1.1.32", "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VDG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZE4-1", "uniprot_id": "PAQR7_MOUSE", "mass": 39306.0, "length": 345, "protein_name": "Membrane progestin receptor alpha", "gene_name": "Paqr7", "organism": "Mouse", "refseq_name": "membrane progestin receptor alpha", "refseq_ac": "NP_001272774", "gene_names_uniprotkb": "Paqr7; Mpra; Pglp", "gene_names_refseq": "2310021M12Rik; Mpra; PGLP; Paqr7; mPR alpha; mPR", "protein_names_uniprotkb": "Membrane progestin receptor alpha; Membrane progesterone P4 receptor alpha; Membrane progesterone receptor alpha; PPAR-gamma-induced liver protein; Progesterone and adipoQ receptor family member 7; Progestin and adipoQ receptor family member 7; Progestin and adipoQ receptor family member VII; mPR alpha", "protein_names_refseq": "PPAR-gamma-induced liver protein; membrane progesterone P4 receptor alpha; membrane progesterone receptor alpha; membrane progestin receptor alpha; progesterone and adipoQ receptor family member 7; progestin and adipoQ receptor family member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:71904)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12601167;15589683;16044242;21750661;24269738;25428506;25605945;27802388;30084848;30779550;34428180;38317224", "class_list": "", "function": "Paqr7 and Paqr8 are expressed in the midbrain ventral tegmental area of proestrous mice., [RefSeq, PubMed]; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone., [UniProtKB, UniProtKB]; Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDA0;Q8BNZ7;Q9D790", "ec_number_list": "", "go_molecular_function": "GO:0003707 nuclear steroid receptor activity;GO:0005496 steroid binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0048545 response to steroid hormone;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80ZE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1B2-1", "uniprot_id": "PARPT_MOUSE", "mass": 75901.0, "length": 657, "protein_name": "Protein mono-ADP-ribosyltransferase TIPARP", "gene_name": "Tiparp", "organism": "Mouse", "refseq_name": "protein mono-ADP-ribosyltransferase TIPARP", "refseq_ac": "NP_849223", "gene_names_uniprotkb": "Tiparp", "gene_names_refseq": "ARTD14; PARP7; Tiparp", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase TIPARP; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 14; ARTD14; TCDD-inducible poly [ADP-ribose] polymerase", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 14; protein mono-ADP-ribosyltransferase TIPARP", "tax_id": 10090, "disease": "", "pathway": " (mmu:99929)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11716501;12147270;21750661;23275542;25428506;34428180;34453220;35055106", "class_list": "", "function": "ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (By similarity). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable)., [UniProtKB, UniProtKB, PubMed]; Knockdown of lncRNA SNHG15 Ameliorates Oxygen and Glucose Deprivation (OGD)-Induced Neuronal Injury via Regulating the miR-9-5p/TIPARP Axis., [RefSeq, PubMed]; Reduced Colonic Mucosal Injury in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Poly ADP-Ribose Polymerase (TIPARP/PARP7)-Deficient Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD50;Q8C032", "ec_number_list": "2.4.2.-;2.4.2.30;2.3.1.-;2.3.1.286", "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0008270 zinc ion binding;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0070213 protein auto-ADP-ribosylation;GO:0001570 vasculogenesis;GO:0010629 negative regulation of gene expression;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C1B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54803-1", "uniprot_id": "P2RX6_MOUSE", "mass": 43099.0, "length": 389, "protein_name": "P2X purinoceptor 6", "gene_name": "P2rx6", "organism": "Mouse", "refseq_name": "P2X purinoceptor 6 isoform 2", "refseq_ac": "NP_001153033", "gene_names_uniprotkb": "P2rx6; P2rxl1", "gene_names_refseq": "P2rx6; P2rxl1; P2x6; P2xm", "protein_names_uniprotkb": "P2X purinoceptor 6; ATP receptor; P2X6; P2XM; Purinergic receptor P2X-like 1; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2X purinoceptor 6 isoform 2; P2X purinoceptor 6; purinergic receptor P2X-like 1, orphan receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18440); (R-MMU-139853); (R-MMU-418346)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17605080;21750661;25874565;27254077;9852680", "class_list": "", "function": "Acts as a modulatory subunit rather than a functional channel. Unlike other P2XRs members, P2RX6 does not seem to form functional homotrimers (By similarity). P2RX6 requires the presence of P2RX4 or P2RX2 to form functional heterotrimeric receptors at the plasma membrane (By similarity). P2RX6 can be translocated to the nucleus, where it interacts with the splicing factor (SF3A1), to reduce the incidence of mRNA splicing. May function as a nuclear regulator of post-transcriptional modifications in neurons (PubMed:25874565)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Immunoreactivity for P2X3-, P2X5-, and P2X6-purinoceptors was observed in mouse retina., [RefSeq, PubMed]; Purinergic signaling via P2X6 is not significantly involved in the regulation of renal electrolyte handling under normal physiological conditions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "G3X8W3;Q3UUD0", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0070588 calcium ion transmembrane transport;GO:0033198 response to ATP", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54803-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z184-1", "uniprot_id": "PADI3_MOUSE", "mass": 75073.0, "length": 664, "protein_name": "Protein-arginine deiminase type-3", "gene_name": "Padi3", "organism": "Mouse", "refseq_name": "protein-arginine deiminase type-3", "refseq_ac": "NP_035190", "gene_names_uniprotkb": "Padi3; Pad3; Pdi3", "gene_names_refseq": "Pad3; Padi3; Pdi3; mKIAA4171", "protein_names_uniprotkb": "Protein-arginine deiminase type-3; 3.5.3.15; Peptidylarginine deiminase III; Protein-arginine deiminase type III", "protein_names_refseq": "PAD type III; PROTEIN-ARGININE DEIMINASE TYPE III (PEPTIDYLARGININE DEIMINASE III); peptidylarginine deiminase III; protein-arginine deiminase type-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:18601); (R-MMU-3247509)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10092850;1778991;21750661;27866708;30084848;36010543", "class_list": "", "function": "Catalyzes the deimination of arginine residues of proteins., [UniProtKB, UniProtKB]; Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their target structural protein TCHH are all involved in hair shaft formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AMU4", "ec_number_list": "3.5.3.15", "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z184-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68ED3-1", "uniprot_id": "PAPD5_MOUSE", "mass": 69704.0, "length": 633, "protein_name": "Terminal nucleotidyltransferase 4B", "gene_name": "Tent4b", "organism": "Mouse", "refseq_name": "terminal nucleotidyltransferase 4B isoform a", "refseq_ac": "NP_001157969", "gene_names_uniprotkb": "Tent4b; Papd5", "gene_names_refseq": "5730445M16Rik; 5830428A09; Papd5; Tent4b", "protein_names_uniprotkb": "Terminal nucleotidyltransferase 4B; 2.7.7.-; 2.7.7.19; Non-canonical poly(A) RNA polymerase PAPD5; PAP-associated domain-containing protein 5; TRF4-2; TUTase 3; Terminal guanylyltransferase; Terminal uridylyltransferase 3; Topoisomerase-related function protein 4-2", "protein_names_refseq": "PAP associated domain containing 5; PAP-associated domain-containing protein 5; TRF4-2; TUTase 3; non-canonical poly(A) RNA polymerase PAPD5; terminal guanylyltransferase; terminal nucleotidyltransferase 4A; terminal nucleotidyltransferase 4B isoform a; terminal uridylyltransferase 3; topoisomerase-related function protein 4-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:214627)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;34428180", "class_list": "", "function": "Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (By similarity). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H635;Q8C0K6", "ec_number_list": "2.7.7.19;2.7.7.52;2.7.7.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031499 TRAMP complex", "go_biological_process": "GO:0033500 carbohydrate homeostasis;GO:0051301 cell division;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0006364 rRNA processing;GO:0071044 histone mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q68ED3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFB9-1", "uniprot_id": "OL183_MOUSE", "mass": 35329.0, "length": 309, "protein_name": "Olfactory receptor 5H17", "gene_name": "Or5h17", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Or5h17; Mor183-2; Olfr183", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor 5H17; Olfactory receptor 183-2; Olfactory receptor 183", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:258478)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VFB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEX6-1", "uniprot_id": "O5H19_MOUSE", "mass": 34648.0, "length": 308, "protein_name": "Olfactory receptor 5H19", "gene_name": "Or5h19", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Or5h19; Mor183-8; Olfr187; Olfr196", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor 5H19; Olfactory receptor 183-8; Olfactory receptor 187", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:258319)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VEX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q63912-1", "uniprot_id": "OMGP_MOUSE", "mass": 49284.0, "length": 440, "protein_name": "Oligodendrocyte-myelin glycoprotein", "gene_name": "Omg", "organism": "Mouse", "refseq_name": "oligodendrocyte-myelin glycoprotein precursor", "refseq_ac": "NP_062282", "gene_names_uniprotkb": "Omg; Omgp", "gene_names_refseq": "Omg", "protein_names_uniprotkb": "Oligodendrocyte-myelin glycoprotein", "protein_names_refseq": "oligodendrocyte-myelin glycoprotein precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18377); (R-MMU-193634)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12068310;21750661;25428506;26192747;30899004;33300544;35822049;40021952;40885482;8244377", "class_list": "", "function": "Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 24, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0098552 side of membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0022010 central nervous system myelination;GO:0031102 neuron projection regeneration;GO:0048683 regulation of collateral sprouting of intact axon in response to injury", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "Q63912-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR10-1", "uniprot_id": "OXLD1_MOUSE", "mass": 22178.0, "length": 201, "protein_name": "Oxidoreductase-like domain-containing protein 1", "gene_name": "Oxld1", "organism": "Mouse", "refseq_name": "oxidoreductase-like domain-containing protein 1 isoform 1", "refseq_ac": "NP_079836", "gene_names_uniprotkb": "Oxld1; 1810049H13Rik", "gene_names_refseq": "1810049H13Rik; Oxld1", "protein_names_uniprotkb": "Oxidoreductase-like domain-containing protein 1", "protein_names_refseq": "oxidoreductase-like domain-containing protein 1 isoform 1; oxidoreductase-like domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66431)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CR10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35103-1", "uniprot_id": "OMD_MOUSE", "mass": 49745.0, "length": 423, "protein_name": "Osteomodulin", "gene_name": "Omd", "organism": "Mouse", "refseq_name": "osteomodulin precursor", "refseq_ac": "NP_036180", "gene_names_uniprotkb": "Omd", "gene_names_refseq": "OSAD; Omd; SLRR2C", "protein_names_uniprotkb": "Osteomodulin; KSPG osteomodulin; Keratan sulfate proteoglycan osteomodulin; OSAD; Osteoadherin", "protein_names_refseq": "KSPG osteomodulin; keratan sulfate proteoglycan osteomodulin; osteoadherin; osteomodulin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:27047); (R-MMU-2022854); (R-MMU-2022857)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "16970923;18496725;37730805;38722812", "class_list": "", "function": "Found transforming growth factor beta1 to down regulate OSAD, while bone morphogenetic protein 2 up regulates OSAD, [RefSeq, PubMed]; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin., [UniProtKB, UniProtKB]; OSAD overexpression enhanced the differentiation and maturation of osteoblasts in vitro., [RefSeq, PubMed]; Osteomodulin deficiency in mice causes a specific reduction of transversal cortical bone size., [RefSeq, PubMed]; Osteomodulin downregulation is associated with osteoarthritis development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35103-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70458-1", "uniprot_id": "OSMR_MOUSE", "mass": 110229.0, "length": 971, "protein_name": "Oncostatin-M-specific receptor subunit beta", "gene_name": "Osmr", "organism": "Mouse", "refseq_name": "oncostatin-M-specific receptor subunit beta isoform 2 precursor", "refseq_ac": "NP_001297398", "gene_names_uniprotkb": "Osmr; Osmrb", "gene_names_refseq": "OSMRB; Osmr", "protein_names_uniprotkb": "Oncostatin-M-specific receptor subunit beta; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; Interleukin-31 receptor subunit beta", "protein_names_refseq": "IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 receptor subunit beta; oncostatin receptor; oncostatin-M-specific receptor subunit beta isoform 2 precursor; oncostatin-M-specific receptor subunit beta", "tax_id": 10090, "disease": "primary localized cutaneous amyloidosis 1 (Disease Ontology:DOID:0080930)", "pathway": " (mmu:18414); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12814362;19656770;21750661;25381841;37828378;39532904;9584176;9920829", "class_list": "", "function": "Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons., [RefSeq, PubMed]; Functions as a shared membrane-bound signal-transducing subunit in two distinct receptor complexes, the type II OSM receptor (heterodimer composed of OSMR and IL6ST) and the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which respectively bind OSM and IL31 (PubMed:9584176, PubMed:9920829). Functionally, OSM signaling via OSMR/IL6ST regulates many processes including cell proliferation, cell differentiation, cytokine production, whereas the IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (By similarity). Mechanistically, in both the OSM-IL6ST/gp130-OSMR and IL31-IL31RA-OSMR complexes, receptor dimerization activates JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL6ST/gp130 and OSMR (or IL31RA and OSMR) (PubMed:9584176). These kinases phosphorylate tyrosine residues on IL6ST/gp130 and OSMR (or IL31RA and OSMR), creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated (PubMed:9584176). In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9474, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "O88821", "ec_number_list": "", "go_molecular_function": "GO:0019838 growth factor binding;GO:0019955 cytokine binding;GO:0004924 oncostatin-M receptor activity;GO:0004896 cytokine receptor activity;GO:0005127 ciliary neurotrophic factor receptor binding", "go_cellular_component": "GO:0005900 oncostatin-M receptor complex;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0038165 oncostatin-M-mediated signaling pathway;GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0034097 response to cytokine;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "O70458-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31482-1", "uniprot_id": "PA2GA_MOUSE", "mass": 16145.0, "length": 146, "protein_name": "Phospholipase A2, membrane associated", "gene_name": "Pla2g2a", "organism": "Mouse", "refseq_name": "phospholipase A2, membrane associated precursor", "refseq_ac": "NP_001076000", "gene_names_uniprotkb": "Pla2g2a", "gene_names_refseq": "EF; Mom1; Pla2g2a; Pla2; sPLA2; sPla2-IIA", "protein_names_uniprotkb": "Phospholipase A2, membrane associated; 3.1.1.4; EF; Enhancing factor; GIIC sPLA2; Group IIA phospholipase A2; Phosphatidylcholine 2-acylhydrolase 2A", "protein_names_refseq": "GIIC sPLA2; enhancing factor; group IIA phospholipase A2; modifier of Min1; non-pancreatic secreted type II phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; phospholipase A2, membrane associated precursor; phospholipase A2, membrane associated; secretory group II phospholipase A2", "tax_id": 10090, "disease": "cholecystolithiasis (Disease Ontology:DOID:11151); allergic conjunctivitis (Disease Ontology:DOID:11204); adult respiratory distress syndrome (Disease Ontology:DOID:11394); depressive disorder (Disease Ontology:DOID:1596); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); gastroesophageal reflux disease (Disease Ontology:DOID:8534); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:18780); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483166); (R-MMU-6803157)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "10358193;11694541;27292189;37673297;38372090;7673223;7781071;8267767;8425615", "class_list": "", "function": "Identification and immunological characterization of PLA2G2A and cell death-associated molecular clusters in idiopathic pulmonary fibrosis., [RefSeq, PubMed]; Inhibition of RXRA-mediated PLA2G2A improves delirium in COPD mice by regulating endoplasmic reticulum stress pathway and inhibiting cell apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Proteins belonging to the phospholipase A2 (PLA2) family hydrolyze phospholipids into sn2 fatty acids and lysophospholipids. They function in a variety of cellular processes, including the digestion of phospholipids and the production of molecules that induce inflammatory responses. This gene encodes a member of the group II class of secretory PLA2s. The secreted enzyme binds to heparin on the cell surface. Mutations in this gene increase the occurrence of intestinal polyps caused by a dominant mutation in the adenomatosis polyposis coli gene. A frameshift inactivates this gene product in some mouse strains including the strain of the reference genome, C57BL/6J, whereas a functional protein is produced in other strains. [provided by RefSeq, Jul 2008]., [RefSeq]; Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (PubMed:10358193, PubMed:11694541, PubMed:8425615). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (By similarity). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (PubMed:27292189). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60871", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;3.1.1.5;2.3.1.43;3.1.1.47;3.1.2.2;3.1.1.3;2.3.1.-;3.1.1.-;3.1.1.32;2.3.1.51;3.1.1.23;3.1.-.-", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0046473 phosphatidic acid metabolic process;GO:0050678 regulation of epithelial cell proliferation;GO:0006954 inflammatory response;GO:0008285 negative regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P31482-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34984-1", "uniprot_id": "OR2A7_MOUSE", "mass": 34569.0, "length": 310, "protein_name": "Olfactory receptor 2A7", "gene_name": "Or2a7", "organism": "Mouse", "refseq_name": "olfactory receptor 2A7", "refseq_ac": "NP_666863", "gene_names_uniprotkb": "Or2a7; Mor261-6; Olfr13", "gene_names_refseq": "K7; MOR261-6; Olfr13; Or2a7", "protein_names_uniprotkb": "Olfactory receptor 2A7; Odorant receptor K7; Olfactory receptor 13; Olfactory receptor 261-6", "protein_names_refseq": "GA_x6K02T2P3E9-4384160-4383228; odorant receptor K7; olfactory receptor 13; olfactory receptor 261-6; olfactory receptor 2A7; olfactory receptor MOR261-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:18310)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7683976", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VFS2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0055037 recycling endosome;GO:0032154 cleavage furrow;GO:0090543 Flemming body", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P34984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49650-1", "uniprot_id": "P2RY1_MOUSE", "mass": 42213.0, "length": 373, "protein_name": "P2Y purinoceptor 1", "gene_name": "P2ry1", "organism": "Mouse", "refseq_name": "P2Y purinoceptor 1", "refseq_ac": "NP_001268945", "gene_names_uniprotkb": "P2ry1", "gene_names_refseq": "P2Y1; P2ry1; P2y1r", "protein_names_uniprotkb": "P2Y purinoceptor 1; ADP receptor; P2Y1; Purinergic receptor", "protein_names_refseq": "ADP receptor; ATP receptor; P2Y purinoceptor 1; P2Y1 receptor", "tax_id": 10090, "disease": "impotence (Disease Ontology:DOID:1875)", "pathway": " (mmu:18441); (R-MMU-416476); (R-MMU-417957); (R-MMU-418592)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10606627;22299025;39117630;7779087", "class_list": "", "function": "Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001621 G protein-coupled ADP receptor activity;GO:0031686 A1 adenosine receptor binding;GO:0045031 G protein-coupled ATP receptor activity;GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0014069 postsynaptic density", "go_biological_process": "GO:0090075 relaxation of muscle;GO:0060406 positive regulation of penile erection;GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P49650-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55086-1", "uniprot_id": "PAR2_MOUSE", "mass": 44752.0, "length": 399, "protein_name": "Proteinase-activated receptor 2", "gene_name": "F2rl1", "organism": "Mouse", "refseq_name": "proteinase-activated receptor 2 precursor", "refseq_ac": "NP_032000", "gene_names_uniprotkb": "F2rl1; Gpcr11; Gpr11; Par2", "gene_names_refseq": "F2rl1; Gpcr11; PAR-2; Par2", "protein_names_uniprotkb": "Proteinase-activated receptor 2; Coagulation factor II receptor-like 1; G protein-coupled receptor 11; PAR-2; Thrombin receptor-like 1", "protein_names_refseq": "G-protein coupled receptor 11; Protease-activated receptor-2; coagulation factor II (thrombin) receptor-like 1; coagulation factor II receptor-like 1; proteinase-activated receptor 2 precursor; proteinase-activated receptor 2; thrombin receptor-like 1", "tax_id": 10090, "disease": "respiratory allergy (Disease Ontology:DOID:0060496); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung disease (Disease Ontology:DOID:850)", "pathway": " (mmu:14063); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "11086091;11859856;12821670;14519665;15879675;15919826;16081834;16476770;17965715;18202198;19845798;20215560;20584806;31219806;38687090;39171684;7890726;9918574", "class_list": "", "function": "PAR2-mediated cellular senescence promotes inflammation and fibrosis in aging and chronic kidney disease., [RefSeq, PubMed]; Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2., [RefSeq, PubMed]; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2r/Par1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with Tlr4 and probably Tlr2 in inflammatory responses and modulates Tlr3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (By similarity). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o)-alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of Ripk1 and Tradd from Tnfr1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves Ikbkb and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of Cops5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by Cops5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as pro-inflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses (By similarity). Mediates activation of pro-inflammatory and pro-fibrotic responses in fibroblasts, triggered by coagulation factor Xa (F10) (PubMed:18202198). Probably mediates activation of barrier protective signaling responses in endothelial cells, triggered by coagulation factor Xa (F10) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015057 thrombin-activated receptor activity;GO:0031681 G-protein beta-subunit binding;GO:0002020 protease binding;GO:0004930 G protein-coupled receptor activity;GO:0032795 heterotrimeric G-protein binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0031143 pseudopodium", "go_biological_process": "GO:0034141 positive regulation of toll-like receptor 3 signaling pathway;GO:0061028 establishment of endothelial barrier;GO:1900135 positive regulation of renin secretion into blood stream;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P55086-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58308-1", "uniprot_id": "OX2R_MOUSE", "mass": 52461.0, "length": 460, "protein_name": "Orexin receptor type 2", "gene_name": "Hcrtr2", "organism": "Mouse", "refseq_name": "orexin receptor type 2 isoform 1", "refseq_ac": "NP_945200", "gene_names_uniprotkb": "Hcrtr2; Mox2r", "gene_names_refseq": "Hcrtr2; OX2R; OX2aR; OX2bR; OXR2; mOX2aR; mOX2bR; mOXR2", "protein_names_uniprotkb": "Orexin receptor type 2; Hypocretin receptor type 2; Ox-2-R; Ox2-R; Ox2R", "protein_names_refseq": "hypocretin receptor type 2; orexin receptor type 2 isoform 1; orexin receptor type 2; orexin receptor type-2a", "tax_id": 10090, "disease": "hyperglycemia (Disease Ontology:DOID:4195); narcolepsy (Disease Ontology:DOID:8986)", "pathway": " (mmu:387285); (R-MMU-389397); (R-MMU-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12399012;12797957;15256537;34475397;38866320", "class_list": "", "function": "G protein-coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin (PubMed:15256537). Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G-proteins thereby initiating distinct downstream signaling cascades (By similarity). Involved in regulating the sleep-wake cycle (PubMed:12797957). Contributes to central regulation of glucose homeostasis (PubMed:34475397)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Hypocretin receptor 2 mRNA levels declined with age in the hippocampus, thalamus, pons, and medulla (hypocretin receptor 2), [RefSeq, PubMed]; Knockdown of type 2 orexin receptor in adult mouse testis potentiates testosterone production and germ cell proliferation., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5SGC8;Q6VLX3;Q8BG12", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017046 peptide hormone binding;GO:0016499 orexin receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0032870 cellular response to hormone stimulus;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P58308-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P86546-1", "uniprot_id": "OSTCN_MOUSE", "mass": 10549.0, "length": 95, "protein_name": "Osteocalcin", "gene_name": "Bglap", "organism": "Mouse", "refseq_name": "osteocalcin preproprotein", "refseq_ac": "NP_031567", "gene_names_uniprotkb": "Bglap; Ocn", "gene_names_refseq": "BGP; Bglap1; Bglap; OC; OG1; mOC-A", "protein_names_uniprotkb": "Osteocalcin; BGP; Bone Gla protein; Gamma-carboxyglutamic acid-containing protein; OG1", "protein_names_refseq": "bone Gla protein; bone gamma carboxyglutamate protein 1; gamma-carboxyglutamic acid-containing protein; osteocalcin preproprotein; osteocalcin", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); polycystic kidney disease (Disease Ontology:DOID:0080322); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); autosomal dominant hypocalcemia (Disease Ontology:DOID:0090109); neurofibromatosis 1 (Disease Ontology:DOID:0111253); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); prostate cancer (Disease Ontology:DOID:10283); vitamin K deficiency bleeding (Disease Ontology:DOID:11249); osteoporosis (Disease Ontology:DOID:11476); nephrotic syndrome (Disease Ontology:DOID:1184); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); calcinosis (Disease Ontology:DOID:182); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetes insipidus (Disease Ontology:DOID:9409); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12096)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17693256;20655470;20655471;21333348;24028588;24074871;28851741;29148101;8288580;8684484", "class_list": "", "function": "The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (By similarity). Acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (PubMed:8684484). Binds strongly to apatite and calcium upon gamma-carboxylation; this modification is essential for bone metabolism (PubMed:17693256)., [UniProtKB, UniProtKB, PubMed, PubMed]; The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development (PubMed:17693256, PubMed:20655470, PubMed:20655471, PubMed:21333348, PubMed:24074871). Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure (PubMed:17693256, PubMed:20655470, PubMed:20655471). Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (PubMed:21333348). Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA) (PubMed:24074871, PubMed:28851741). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development (PubMed:24074871)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes one of the most abundant non-collagenous proteins in bone tissue that is localized to the mineralized matrix of bone. The encoded preproprotein undergoes proteolytic processing and post-translational gamma carboxylation to generate a mature, calcium-binding protein. Mice lacking the encoded protein develop abnormalities of bone remodelling. This gene is located adjacent to two other osteocalcin-related genes on chromosome 3. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04641", "ec_number_list": "", "go_molecular_function": "GO:0008147 structural constituent of bone;GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0016311 dephosphorylation;GO:1900076 regulation of cellular response to insulin stimulus;GO:1903011 negative regulation of bone development;GO:0007611 learning or memory;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P86546-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97391-1", "uniprot_id": "PA2G5_MOUSE", "mass": 15859.0, "length": 137, "protein_name": "Phospholipase A2 group V", "gene_name": "Pla2g5", "organism": "Mouse", "refseq_name": "phospholipase A2 group V precursor", "refseq_ac": "NP_001116426", "gene_names_uniprotkb": "Pla2g5", "gene_names_refseq": "PLA2-10; PLA2; Pla2g5; sPLA2", "protein_names_uniprotkb": "Phospholipase A2 group V; 3.1.1.4; PLA2-10; Phosphatidylcholine 2-acylhydrolase 5", "protein_names_refseq": "calcium-dependent phospholipase A2; group V phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; phospholipase A2 group V precursor", "tax_id": 10090, "disease": "familial benign fleck retina (Disease Ontology:DOID:0111677)", "pathway": " (mmu:18784); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483166)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "10531350;11694541;14962950;16407308;19342668;20432503;20817863;24910243;29346348;38361249;8838795", "class_list": "", "function": "Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment. Erratum:[Immunology. 2025 Nov;176(3):403-406. doi: 10.1111/imm.70017. PMID: 40707417], [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (PubMed:14962950). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (PubMed:14962950, PubMed:24910243). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes (By similarity). Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines (By similarity). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing the phospholipids of the bacterial membrane (PubMed:11694541, PubMed:16407308). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (PubMed:19342668). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (By similarity). In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way (By similarity). In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (By similarity). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (PubMed:20432503). May regulate antigen processing in antigen-presenting cells (PubMed:20817863). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (PubMed:29346348). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZU6", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;3.1.1.5;2.3.1.43;3.1.1.47;3.1.2.2;3.1.1.3;2.3.1.-;3.1.1.-;3.1.1.32;2.3.1.51;3.1.1.23;3.1.-.-", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006663 platelet activating factor biosynthetic process;GO:0034638 phosphatidylcholine catabolic process;GO:0006631 fatty acid metabolic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0042130 negative regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P97391-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08642-1", "uniprot_id": "PADI2_MOUSE", "mass": 76250.0, "length": 673, "protein_name": "Protein-arginine deiminase type-2", "gene_name": "Padi2", "organism": "Mouse", "refseq_name": "protein-arginine deiminase type-2 isoform 1", "refseq_ac": "NP_032838", "gene_names_uniprotkb": "Padi2; Pad2; Pdi2; Pdi", "gene_names_refseq": "Padi2; Pdi2; Pdi; mKIAA0994", "protein_names_uniprotkb": "Protein-arginine deiminase type-2; 3.5.3.15; Peptidylarginine deiminase II; Protein-arginine deiminase type II", "protein_names_refseq": "PAD type II; peptidyl arginine deiminase, type II; peptidylarginine deiminase II; protein-arginine deiminase type II; protein-arginine deiminase type-2 isoform 1; protein-arginine deiminase type-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18600); (R-MMU-3247509); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15087120;1778991;33300544;34428180;36010543;37310889;39927985;8354274", "class_list": "", "function": "Catalyzes the deimination of arginine residues of proteins., [UniProtKB, UniProtKB]; Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q75WD0", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.2.1.17;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.2.1.52;3.2.1.23;3.4.21.20;2.7.10.2;2.7.11.13;3.6.1.-;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.4.21.37;3.1.6.4;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.1.6.14;3.1.3.16;5.3.99.3;6.3.4.21;2.4.1.1;2.3.3.8;1.8.4.-;5.3.4.1;3.2.1.51;1.6.2.2;3.4.14.2;3.4.21.4;3.4.19.9", "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0030331 nuclear estrogen receptor binding;GO:0140794 histone arginine deiminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000791 euchromatin", "go_biological_process": "GO:0070100 negative regulation of chemokine-mediated signaling pathway;GO:1901624 negative regulation of lymphocyte chemotaxis;GO:0006338 chromatin remodeling;GO:1990830 cellular response to leukemia inhibitory factor;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q08642-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VAX9-1", "uniprot_id": "O7178_MOUSE", "mass": 37358.0, "length": 331, "protein_name": "Olfactory receptor 7E178", "gene_name": "Or7e178", "organism": "Mouse", "refseq_name": "olfactory receptor 7E178", "refseq_ac": "NP_666774", "gene_names_uniprotkb": "Or7e178; Mor145-1; Olfr18", "gene_names_refseq": "MOR145-1; MTPCR34; Olfr18; Or7e178", "protein_names_uniprotkb": "Olfactory receptor 7E178; Olfactory receptor 145-1; Olfactory receptor 18; Olfactory receptor TPCR34", "protein_names_refseq": "GA_x6K02T2PVTD-14054886-14053957; olfactory receptor 145-1; olfactory receptor 18; olfactory receptor 7E178; olfactory receptor TPCR34", "tax_id": 10090, "disease": "", "pathway": " (mmu:18315)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;9119360", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62337;Q7TRE8;Q8VFJ2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VAX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UU35-1", "uniprot_id": "OVOS_MOUSE", "mass": 162340.0, "length": 1456, "protein_name": "Alpha-2-macroglobulin-like protein 1", "gene_name": "A2ml1", "organism": "Mouse", "refseq_name": "alpha-2-macroglobulin-like protein 1 precursor", "refseq_ac": "NP_001001179", "gene_names_uniprotkb": "A2ml1; Ovos; mOH", "gene_names_refseq": "A2ml1; Ovos2; Ovos", "protein_names_uniprotkb": "Alpha-2-macroglobulin-like protein 1; Ovostatin homolog", "protein_names_refseq": "alpha-2-macroglobulin-like protein 1 precursor; alpha-2-macroglobulin-like protein 1; ovostatin homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:232400)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;30899053;38759260", "class_list": "", "function": "A complex of novel protease inhibitor, ovostatin homolog, with its cognate proteases in immature mice uterine luminal fluid. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits protease gelatinolytic complex activity against type 1 collagen., [UniProtKB, PubMed]; The A2ml1-Knockout mouse as an animal model for non-syndromic otitis media., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "E9QMV5", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0042474 middle ear morphogenesis;GO:0043583 ear development;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3UU35-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1G4-1", "uniprot_id": "OLM2B_MOUSE", "mass": 83503.0, "length": 746, "protein_name": "Olfactomedin-like protein 2B", "gene_name": "Olfml2b", "organism": "Mouse", "refseq_name": "olfactomedin-like protein 2B isoform 3 precursor", "refseq_ac": "NP_796042", "gene_names_uniprotkb": "Olfml2b", "gene_names_refseq": "1110018N05Rik; 4832415H08Rik; Olfml2b", "protein_names_uniprotkb": "Olfactomedin-like protein 2B; Photomedin-2", "protein_names_refseq": "olfactomedin-like protein 2B isoform 3 precursor; olfactomedin-like protein 2B; photomedin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:320078)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15836428;31219806;34428180;35820727", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9I5;Q8C106;Q8R3B2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007165 signal transduction;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3V1G4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4ZJM7-1", "uniprot_id": "OTOL1_MOUSE", "mass": 49601.0, "length": 482, "protein_name": "Otolin-1", "gene_name": "Otol1", "organism": "Mouse", "refseq_name": "otolin-1 precursor", "refseq_ac": "NP_001018041", "gene_names_uniprotkb": "Otol1; Gm414", "gene_names_refseq": "Gm414; Otol1", "protein_names_uniprotkb": "Otolin-1", "protein_names_refseq": "otolin 1 homolog; otolin-1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:229389)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15905077;17300776;20856818;21655225;22841569;24748133;29076638", "class_list": "", "function": "Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear (PubMed:21655225, PubMed:24748133, PubMed:29076638). Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure (PubMed:21655225, PubMed:24748133, PubMed:29076638). Together with OC90, modulates calcite crystal morphology and growth kinetics (PubMed:24748133)., [UniProtKB, PubMed, PubMed, PubMed]; Identification and functional characterization of a similar protein in zebrafish., [RefSeq, PubMed]; Otolin 1 interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1 in the inner ear. Publication Status: Online-Only, [RefSeq, PubMed]; Report otoconin 90 is attached to a scaffold consisting of the hexagonal fibrillar meshwork, characteristic of otolin, in the otoconia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EKG7;Q3TYP6", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0051260 protein homooligomerization;GO:0045299 otolith mineralization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q4ZJM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60879-1", "uniprot_id": "OR1J1_MOUSE", "mass": 34969.0, "length": 313, "protein_name": "Olfactory receptor 1J1", "gene_name": "Or1j1", "organism": "Mouse", "refseq_name": "olfactory receptor 1J1", "refseq_ac": "NP_996786", "gene_names_uniprotkb": "Or1j1; Mor136-14; Olfr3", "gene_names_refseq": "MOR136-14; Olfr3; Or1j1; Y71", "protein_names_uniprotkb": "Olfactory receptor 1J1; Odorant receptor K10; Olfactory receptor 136-14; Olfactory receptor 3", "protein_names_refseq": "GA_x6K02T2NLDC-33507606-33506665; odorant receptor K10; olfactory receptor 136-14; olfactory receptor 1J1; olfactory receptor 3; olfactory receptor MOR136-14", "tax_id": 10090, "disease": "", "pathway": " (mmu:18328)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34428180;8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VFP7", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60879-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60881-1", "uniprot_id": "O4B13_MOUSE", "mass": 34312.0, "length": 305, "protein_name": "Olfactory receptor 4B13", "gene_name": "Or4b13", "organism": "Mouse", "refseq_name": "olfactory receptor 4B13", "refseq_ac": "NP_667195", "gene_names_uniprotkb": "Or4b13; Mor227-2; Olfr142; Olfr4", "gene_names_refseq": "K20; MOR227-2; Olfr142; Or4b13", "protein_names_uniprotkb": "Olfactory receptor 4B13; Olfactory receptor 142; Olfactory receptor 227-2; Olfactory receptor 4C", "protein_names_refseq": "GA_x6K02T2Q125-51607674-51606757; olfactory receptor 142; olfactory receptor 227-2; olfactory receptor 4B13; olfactory receptor 4C", "tax_id": 10090, "disease": "", "pathway": " (mmu:406186)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VGP2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60881-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60882-1", "uniprot_id": "OR8B8_MOUSE", "mass": 34451.0, "length": 310, "protein_name": "Olfactory receptor 8B8", "gene_name": "Or8b8", "organism": "Mouse", "refseq_name": "olfactory receptor 8B8", "refseq_ac": "NP_666425", "gene_names_uniprotkb": "Or8b8; Mor161-6; Olfr145; Olfr7", "gene_names_refseq": "K21; MOR161-6; Olfr145; Or8b8", "protein_names_uniprotkb": "Olfactory receptor 8B8; Odorant receptor K21; Olfactory receptor 145; Olfactory receptor 161-6; Olfactory receptor 7C", "protein_names_refseq": "GA_x6K02T2PVTD-31578734-31579666; odorant receptor K21; olfactory receptor 145; olfactory receptor 161-6; olfactory receptor 7C; olfactory receptor 8B8; olfactory receptor MOR161-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:258310)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11130974;8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQB0", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60883-1", "uniprot_id": "O2Y1B_MOUSE", "mass": 34270.0, "length": 311, "protein_name": "Olfactory receptor 2Y1B", "gene_name": "Or2y1b", "organism": "Mouse", "refseq_name": "olfactory receptor 2Y1B", "refseq_ac": "NP_996558", "gene_names_uniprotkb": "Or2y1b; Olfr10", "gene_names_refseq": "GA_x6K02T2QP88-6117098-6116163; L45; MOR256-55; Olfr10; Or2y1b", "protein_names_uniprotkb": "Olfactory receptor 2Y1B; Odorant receptor L45; Olfactory receptor 10", "protein_names_refseq": "odorant receptor L45; olfactory receptor 10; olfactory receptor 2Y1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:18307)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7E1Z7;Q7TQS9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q60883-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60885-1", "uniprot_id": "10P22_MOUSE", "mass": 34611.0, "length": 312, "protein_name": "Olfactory receptor 10P22", "gene_name": "Or10p22", "organism": "Mouse", "refseq_name": "olfactory receptor 10P22", "refseq_ac": "NP_667072", "gene_names_uniprotkb": "Or10p22; Mor269-3; Olfr9", "gene_names_refseq": "MOR269-3; Olfr9; Or10p22", "protein_names_uniprotkb": "Olfactory receptor 10P22; Odorant receptor M25; Olfactory receptor 269-3; Olfactory receptor 9", "protein_names_refseq": "GA_x6K02T2PULF-10675610-10676548; odorant receptor M25; olfactory receptor 10P22; olfactory receptor 269-3; olfactory receptor 9; olfactory receptor MOR269-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:18373)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VGC0", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q60885-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60887-1", "uniprot_id": "O10N1_MOUSE", "mass": 34662.0, "length": 310, "protein_name": "Olfactory receptor 10N1", "gene_name": "Or10n1", "organism": "Mouse", "refseq_name": "olfactory receptor 10N1", "refseq_ac": "NP_666716", "gene_names_uniprotkb": "Or10n1; Mor224-4; Olfr148; Olfr7", "gene_names_refseq": "M30; MOR224-4; Olfr148; Or10n1", "protein_names_uniprotkb": "Olfactory receptor 10N1; Odorant receptor M30; Olfactory receptor 148; Olfactory receptor 224-4; Olfactory receptor 7F", "protein_names_refseq": "GA_x6K02T2PVTD-33310486-33311418; odorant receptor M30; olfactory receptor 10N1; olfactory receptor 148; olfactory receptor 224-4; olfactory receptor 7F; olfactory receptor MOR224-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:258498)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11130974;8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQ88", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60887-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60888-1", "uniprot_id": "10D1B_MOUSE", "mass": 35274.0, "length": 311, "protein_name": "Olfactory receptor 10D1B", "gene_name": "Or10d1b", "organism": "Mouse", "refseq_name": "olfactory receptor 10D1B", "refseq_ac": "NP_997021", "gene_names_uniprotkb": "Or10d1b; Mor224-8; Olfr149; Olfr7", "gene_names_refseq": "M31; MOR224-8; Olfr149; Or10d1b", "protein_names_uniprotkb": "Olfactory receptor 10D1B; Odorant receptor M31; Olfactory receptor 149; Olfactory receptor 224-8; Olfactory receptor 7G", "protein_names_refseq": "GA_x6K02T2PVTD-33400306-33399371; odorant receptor M31; olfactory receptor 10D1B; olfactory receptor 149; olfactory receptor 224-8; olfactory receptor 7G; olfactory receptor GA_x5J8B7W3WPH-39574-39485; olfactory receptor MOR224-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:235256)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ08;Q7TRA8;Q8VEP7", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q60888-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60889-1", "uniprot_id": "OR6Z7_MOUSE", "mass": 35281.0, "length": 312, "protein_name": "Olfactory receptor 6Z7", "gene_name": "Or6z7", "organism": "Mouse", "refseq_name": "olfactory receptor 6Z7", "refseq_ac": "NP_667125", "gene_names_uniprotkb": "Or6z7; Mor103-8; Olfr5", "gene_names_refseq": "MOR103-8; ORL120; Olfr5; Or6z7", "protein_names_uniprotkb": "Olfactory receptor 6Z7; Odorant receptor M41; Olfactory receptor 103-8; Olfactory receptor 5", "protein_names_refseq": "GA_x6K02T2QGBW-3210997-3210059; odorant receptor M41; olfactory receptor 103-8; olfactory receptor 5; olfactory receptor 6Z7", "tax_id": 10090, "disease": "", "pathway": " (mmu:18349)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3MI75;Q8VGH4", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q60889-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60892-1", "uniprot_id": "O7A42_MOUSE", "mass": 34792.0, "length": 310, "protein_name": "Olfactory receptor 7A42", "gene_name": "Or7a42", "organism": "Mouse", "refseq_name": "olfactory receptor 7A42", "refseq_ac": "NP_997084", "gene_names_uniprotkb": "Or7a42; Olfr8", "gene_names_refseq": "GA_x5J8B7TNKDU-1250-1574; MOR139-5P; Olfr8; Or7a42", "protein_names_uniprotkb": "Olfactory receptor 7A42; Odorant receptor M64; Olfactory receptor 8", "protein_names_refseq": "GA_x6K02T2QGN0-2857086-2856154; odorant receptor M64; olfactory receptor 7A42; olfactory receptor 8; olfactory receptor GA_x5J8B7TNKDU-1250-1574", "tax_id": 10090, "disease": "", "pathway": " (mmu:18372)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10706615;11014824;8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQV0;Q9ERY5;Q9JM18", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q60892-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60893-1", "uniprot_id": "OR8A1_MOUSE", "mass": 34465.0, "length": 309, "protein_name": "Olfactory receptor 8A1", "gene_name": "Or8a1", "organism": "Mouse", "refseq_name": "olfactory receptor 8A1", "refseq_ac": "NP_997547", "gene_names_uniprotkb": "Or8a1; Mor171-2; Olfr151; Olfr7", "gene_names_refseq": "M71; MOR171-2; Olfr151; Or8a1", "protein_names_uniprotkb": "Olfactory receptor 8A1; Odorant receptor M71; Olfactory receptor 151; Olfactory receptor 171-2; Olfactory receptor 7H", "protein_names_refseq": "GA_x6K02T2PVTD-31408136-31407207; M71 odorant receptor; odorant receptor M71; olfactory receptor 151; olfactory receptor 171-2; olfactory receptor 7H; olfactory receptor 8A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:406176)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene appears to represent a strain-specific polymorphic pseudogene in mouse, where some strains, including the C57BL/6 reference genome strain, have a non-functional allele, while other strains have a protein-coding allele. [provided by RefSeq, Jan 2019]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQX1;Q7TRE7;Q9ERU6", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60893-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60894-1", "uniprot_id": "O9S13_MOUSE", "mass": 36180.0, "length": 333, "protein_name": "Olfactory receptor 9S13", "gene_name": "Or9s13", "organism": "Mouse", "refseq_name": "olfactory receptor 9S13", "refseq_ac": "NP_996779", "gene_names_uniprotkb": "Or9s13; Olfr12", "gene_names_refseq": "MOR208-5; Olfr12; Or9s13", "protein_names_uniprotkb": "Olfactory receptor 9S13; Odorant receptor M76; Olfactory receptor 12", "protein_names_refseq": "GA_x6K02T2R7CC-81134096-81133095; odorant receptor M76; olfactory receptor 12; olfactory receptor 9S13", "tax_id": 10090, "disease": "", "pathway": " (mmu:257890)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQS5", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q60894-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60895-1", "uniprot_id": "O8G50_MOUSE", "mass": 35457.0, "length": 312, "protein_name": "Olfactory receptor 8G50", "gene_name": "Or8g50", "organism": "Mouse", "refseq_name": "olfactory receptor 8G50", "refseq_ac": "NP_666820", "gene_names_uniprotkb": "Or8g50; Mor171-18; Olfr150; Olfr7", "gene_names_refseq": "M93; MOR171-18; Olfr150; Or8g50", "protein_names_uniprotkb": "Olfactory receptor 8G50; Odorant receptor M93; Olfactory receptor 150; Olfactory receptor 171-18; Olfactory receptor 7I", "protein_names_refseq": "GA_x6K02T2PVTD-33434302-33435240; odorant receptor M93; olfactory receptor 150; olfactory receptor 171-18; olfactory receptor 7I; olfactory receptor 8G50", "tax_id": 10090, "disease": "", "pathway": " (mmu:258602)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLS5;Q8VFN2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q60895-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IE21-1", "uniprot_id": "OTU6A_MOUSE", "mass": 33738.0, "length": 290, "protein_name": "OTU domain-containing protein 6A", "gene_name": "Otud6a", "organism": "Mouse", "refseq_name": "OTU domain-containing protein 6A", "refseq_ac": "NP_001156663", "gene_names_uniprotkb": "Otud6a; Hin6", "gene_names_refseq": "EG408193; Hshin6; Otud6a", "protein_names_uniprotkb": "OTU domain-containing protein 6A; 3.4.19.12; Hin-6 protease", "protein_names_refseq": "Hin-6 protease; OTU domain-containing protein 6A", "tax_id": 10090, "disease": "", "pathway": " (mmu:408193)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15060002;35820727;36932155;37632103;38105755;38342418", "class_list": "", "function": "Deubiquitinase OTUD6A Regulates Innate Immune Response via Targeting UBC13. Publication Status: Online-Only, [RefSeq, PubMed]; Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3., [RefSeq, PubMed]; Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING., [RefSeq, PubMed]; Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains (By similarity)., [UniProtKB]; OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ADU1;A8E630", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0035523 protein K29-linked deubiquitination;GO:1990167 protein K27-linked deubiquitination;GO:1990168 protein K33-linked deubiquitination;GO:0035871 protein K11-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6IE21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NVF0-1", "uniprot_id": "OCRL_MOUSE", "mass": 104285.0, "length": 900, "protein_name": "Inositol polyphosphate 5-phosphatase OCRL", "gene_name": "Ocrl", "organism": "Mouse", "refseq_name": "inositol polyphosphate 5-phosphatase OCRL", "refseq_ac": "NP_796189", "gene_names_uniprotkb": "Ocrl; Ocrl1", "gene_names_refseq": "9530014D17Rik; OCRL1; Ocrl", "protein_names_uniprotkb": "Inositol polyphosphate 5-phosphatase OCRL; 3.1.3.36; 3.1.3.56; 3.1.3.86; Inositol polyphosphate 5-phosphatase OCRL-1; Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase", "protein_names_refseq": "inositol polyphosphate 5-phosphatase OCRL-1; inositol polyphosphate 5-phosphatase OCRL; oculocerebrorenal syndrome of Lowe; phosphatidylinositol 3,4,5-triphosphate 5-phosphatase", "tax_id": 10090, "disease": "Dent disease 2 (Disease Ontology:DOID:0081454); oculocerebrorenal syndrome (Disease Ontology:DOID:1056)", "pathway": " (mmu:320634); (R-MMU-1660499); (R-MMU-1660514); (R-MMU-1855183); (R-MMU-1855204); (R-MMU-432722); (R-MMU-8856828); (R-MMU-9013409); (R-MMU-9013423)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;18034455;19021631;21750661;25428506;25869668;30590522;31219806;33987909;34428180;34731604", "class_list": "", "function": "Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling., [UniProtKB, UniProtKB]; OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring., [RefSeq, PubMed]; SdhA blocks disruption of the Legionella-containing vacuole by hijacking the OCRL phosphatase., [RefSeq, PubMed]; The results indicate that OCRL1 restricts intracellular growth of L. pneumophila and binds to Legionella-containing vacuoles in association with Legionella LpnE., [RefSeq, PubMed]; These studies substantiate the first mouse model of Lowe syndrome and give insights into the role of OCRL in cellular trafficking of multiligand receptors. These insights open new avenues for therapeutic interventions in Lowe syndrome and Dent disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXC9", "ec_number_list": "3.4.17.22;3.1.3.67;3.1.3.86;3.1.3.95;3.1.3.36;2.3.2.27;5.6.1.6;3.6.5.2;3.6.5.5;3.1.3.56;3.6.4.-;3.6.4.10;2.7.10.1;2.7.11.1;2.7.1.153;2.7.1.137;2.7.1.154;3.1.3.-;2.7.1.134;2.7.1.159;3.1.3.16", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0052745 inositol phosphate phosphatase activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0060271 cilium assembly;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6NVF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFG8-1", "uniprot_id": "OLIG3_MOUSE", "mass": 29507.0, "length": 273, "protein_name": "Oligodendrocyte transcription factor 3", "gene_name": "Olig3", "organism": "Mouse", "refseq_name": "oligodendrocyte transcription factor 3", "refseq_ac": "NP_443734", "gene_names_uniprotkb": "Olig3; Bhlhb7", "gene_names_refseq": "Bhlhb7; Olig3; bHLHe20; oligo3", "protein_names_uniprotkb": "Oligodendrocyte transcription factor 3; Class B basic helix-loop-helix protein 7; Oligo3; Oligodendrocyte-specific bHLH transcription factor 3; bHLHb7", "protein_names_refseq": "basic helix-loop-helix domain-containing class B protein 7; oligodendrocyte transcription factor 3; oligodendrocyte-specific bHLH transcription factor 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:94222)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11091082;11960707;15769945", "class_list": "", "function": "May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons., [UniProtKB, PubMed]; Olig3 expression distinguishes the two major classes of progenitors in the dorsal spinal cord and determines the distinct specification program of class A neurons., [RefSeq, PubMed]; Olig3 is specifically and transiently expressed in different types of progenitors of embryonic central nervous system and then disappears in the course of development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQW5", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0097476 spinal cord motor neuron migration;GO:0021520 spinal cord motor neuron cell fate specification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PFG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6VZZ7-1", "uniprot_id": "OPN5_MOUSE", "mass": 42018.0, "length": 377, "protein_name": "Opsin-5", "gene_name": "Opn5", "organism": "Mouse", "refseq_name": "opsin-5", "refseq_ac": "NP_861418", "gene_names_uniprotkb": "Opn5; Gpr136; Pgr12", "gene_names_refseq": "Gpr136; Neuropsin; Opn5; PGR12; TMEM13", "protein_names_uniprotkb": "Opsin-5; G protein-coupled receptor 136; G protein-coupled receptor PGR12; Neuropsin", "protein_names_refseq": "G protein-coupled receptor 136; G-protein coupled receptor PGR12; opsin-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:353344); (R-MMU-418594); (R-MMU-419771)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12679517;14623098;14623103;22043319;22972991;26392540;30240620;30936473;31607531;38206094;40700017", "class_list": "", "function": "G protein-coupled photoreceptor that selectively activates G(i) protein via light-mediated activation in the retina (PubMed:22043319). Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (PubMed:22043319). Acts as a bistable protein with absorption peaks at 380 nm (UVA light) and 470 nm (blue light), allowing photoreversible regeneration of the cis-retinal chromophore after stimulation (PubMed:22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (PubMed:30936473). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (PubMed:26392540, PubMed:30240620). Acts as a circadian photoreceptor in the outer ear and vibrissal pads, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (PubMed:31607531). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (PubMed:30936473). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (PubMed:30936473). Mediates violet light-accelerated wound healing in corneas, being transiently expressed following physical injury (PubMed:40700017)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Neuropsin promotes hippocampal synaptogenesis by regulating the expression and cleavage of L1CAM., [RefSeq, PubMed]; OPN5 was capable of activating heterotrimeric G protein Gi in a UV-dependent manner, [RefSeq, PubMed]; Thus, ErbB4 signaling induced by neuropsin-dependent processing of NRG-1 contributes to the modulation of synaptic plasticity via regulation of GABAergic transmission., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q059L5;Q7TQP1;Q80T51;Q8BYI2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005502 11-cis retinal binding;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:1990384 hyaloid vascular plexus regression;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0090303 positive regulation of wound healing;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6VZZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6W049-1", "uniprot_id": "56B34_MOUSE", "mass": 35690.0, "length": 321, "protein_name": "Olfactory receptor 56B34", "gene_name": "Or56b34", "organism": "Mouse", "refseq_name": "olfactory receptor 56B34", "refseq_ac": "NP_001011533", "gene_names_uniprotkb": "Or56b34; Olfr688", "gene_names_refseq": "MOR40-16; MOR40-5; Olfr688-ps1; Olfr688; Or56b34", "protein_names_uniprotkb": "Olfactory receptor 56B34; Olfactory receptor 688", "protein_names_refseq": "GA_x6K02T2PBJ9-7917168-7918148; olfactory receptor 56B34; olfactory receptor 688, pseudogene 1; olfactory receptor MOR40-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:259161)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PVA1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6W049-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M750-1", "uniprot_id": "OPALI_MOUSE", "mass": 15833.0, "length": 143, "protein_name": "Opalin", "gene_name": "Opalin", "organism": "Mouse", "refseq_name": "opalin", "refseq_ac": "NP_705740", "gene_names_uniprotkb": "Opalin; Tmem10", "gene_names_refseq": "Opalin; Tmem10; Tmp10", "protein_names_uniprotkb": "Opalin; Oligodendrocytic myelin paranodal and inner loop protein; Transmembrane protein 10", "protein_names_refseq": "opalin; transmembrane protein 10; transmembrane protein TMP10", "tax_id": 10090, "disease": "", "pathway": " (mmu:226115)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11814680;17442045;18439243;18490449;27855200;30837646;33215680;33300544", "class_list": "", "function": "Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation., [UniProtKB, PubMed]; Decreased turnover of the CNS myelin protein Opalin in a mouse model of hereditary spastic paraplegia 35., [RefSeq, PubMed]; Highly sialylglycosylated Opalin has a role in an intermembranous function of the myelin paranodal loops in the central nervous system, [RefSeq, PubMed]; Together, our results demonstrate that Tmem10 is a novel marker for in vitro generated oligodendrocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 2, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6P903", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0044291 cell-cell contact zone", "go_biological_process": "GO:0048713 regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q7M750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UF9-1", "uniprot_id": "OTOP3_MOUSE", "mass": 64743.0, "length": 577, "protein_name": "Proton channel OTOP3", "gene_name": "Otop3", "organism": "Mouse", "refseq_name": "proton channel OTOP3 isoform 2", "refseq_ac": "NP_001334576", "gene_names_uniprotkb": "Otop3", "gene_names_refseq": "2310011E08Rik; Otop3", "protein_names_uniprotkb": "Proton channel OTOP3; Otopetrin-3", "protein_names_refseq": "proton channel OTOP3 isoform 2; proton channel OTOP3", "tax_id": 10090, "disease": "", "pathway": " (mmu:69602)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12651873;21750661;29371428;37023615;37053086", "class_list": "", "function": "Proton-selective channel gated by extracellular protons., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A6S7;B9EKA4;Q7M736;Q810B4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0015252 proton channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80UF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VM9-1", "uniprot_id": "OTOP1_MOUSE", "mass": 65755.0, "length": 600, "protein_name": "Proton channel OTOP1", "gene_name": "Otop1", "organism": "Mouse", "refseq_name": "proton channel OTOP1", "refseq_ac": "NP_766297", "gene_names_uniprotkb": "Otop1", "gene_names_refseq": "A530025J20Rik; Otop1; Otp1; tlt", "protein_names_uniprotkb": "Proton channel OTOP1; Otopetrin-1", "protein_names_refseq": "proton channel OTOP1; tilted", "tax_id": 10090, "disease": "", "pathway": " (mmu:21906)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12651873;17606897;20554841;21236346;21750661;24379350;29371428;31160780;31543264;31543453;36596786;37053086;37798269;37812612", "class_list": "", "function": "Loss of Otopetrin 1 affects thermoregulation during fasting in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Otop1 and other members of the Otopetrin gene family encode proton-selective ion channels. Otop1 is expressed in taste bud cells that detect sour taste and is required for the proton current in these cells., [RefSeq, PubMed]; Proton-selective ion channel (PubMed:29371428, PubMed:31160780, PubMed:31543453, PubMed:36596786, PubMed:37798269). Biphasically modulated by acid and alkali, mediating proton influx and efflux in response to extracellular acid and base stimulation, respectively (PubMed:36596786, PubMed:37798269). Sour taste receptor, which carries inward currents in response to extracellular acidification (PubMed:29371428, PubMed:31543264, PubMed:31543453, PubMed:37053086). Sensor for ammonium chloride (NH(4)Cl) in taste receptor cells. NH(4)Cl acts by increasing the intracellular pH, thereby generating a driving force for proton entry through OTOP1 channel (PubMed:37798269). Might also participate in alkaline sensation (PubMed:37798269). Plays a role in the regulation of Ca(2+) flux in response to purigenic (ATP, ADP and UDP) stimuli, leading to increase in cytosolic Ca(2+) due to influx of extracellular calcium (PubMed:17606897, PubMed:20554841). May play this role by inhibiting P2Y purinoceptor-mediated Ca(2+) release in a Ca(2+)-dependent manner and promote an influx of Ca(2+) in response to ATP (PubMed:20554841). Through this mechanism and possibly others, plays a role in the formation and function of calcium carbonate-based structures in the vestibular system of the inner ear, called otoconia, that sense gravity and linear acceleration (PubMed:12651873, PubMed:20554841). In obesity, may attenuate adipose tissue inflammation, through the negative regulation of IFNG signaling, hence may play an adaptive role in the maintainance of metabolic homeostasis (PubMed:24379350). Following alkali activation, may also be permeable Na(+), K(+), Cs(+) and Li(+) (PubMed:37798269)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The proton channel OTOP1 is a sensor for the taste of ammonium chloride. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J1J4;E9QMU2;Q7M735;Q8BRZ4;Q8BS22", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0015252 proton channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005902 microvillus", "go_biological_process": "GO:0009590 detection of gravity;GO:0032869 cellular response to insulin stimulus;GO:0042472 inner ear morphogenesis;GO:0060336 negative regulation of type II interferon-mediated signaling pathway;GO:0032475 otolith formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80VM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFQ3-1", "uniprot_id": "GPR68_MOUSE", "mass": 41209.0, "length": 365, "protein_name": "G protein-coupled receptor 68", "gene_name": "Gpr68", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 68", "refseq_ac": "NP_001171144", "gene_names_uniprotkb": "Gpr68; Ogr1", "gene_names_refseq": "Gpr68; Ogr1", "protein_names_uniprotkb": "G protein-coupled receptor 68; Ovarian cancer G protein-coupled receptor 1 homolog", "protein_names_refseq": "G-protein coupled receptor 68; ovarian cancer G-protein coupled receptor 1 homolog; ovarian cancer G-protein coupled receptor 1; sphingosylphosphorylcholine receptor", "tax_id": 10090, "disease": "amelogenesis imperfecta type 2A6 (Disease Ontology:DOID:0080960)", "pathway": " (mmu:238377); (R-MMU-373076); (R-MMU-416476)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "12679517;17576169;17728215;18847331;19479052;26261299;26550826;29677517;34428180;34722644;35489647;36210013;36611126;39269448", "class_list": "", "function": "GPR68 limits the severity of chemical-induced oral epithelial dysplasia. Publication Status: Online-Only, [RefSeq, PubMed]; OGR1 induces an increase in Ca(i) in response to acidic medium and is a prime candidate for an osteoblast proton sensor., [RefSeq, PubMed]; PH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A., [RefSeq, PubMed]; Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (By similarity). The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (By similarity). GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (By similarity). Acts as a key mechanosensor of fluid shear stress and membrane stretch (PubMed:29677517). Expressed in endothelial cells of small-diameter resistance arteries, where it mediates flow-induced dilation in response to shear stress (PubMed:29677517). May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone (PubMed:18847331). Acts as a regulator of calcium-sensing receptor CASR in a seesaw manner: GPR68-mediated signaling inhibits CASR signaling in response to protons, while CASR inhibits GPR68 in presence of extracellular calcium (PubMed:26261299). Also functions as a metastasis suppressor gene in prostate cancer (PubMed:17728215)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Regulator of G-protein signaling 18 acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway, [RefSeq, PubMed]; The orphan receptor GPR68 is expressed in the hypothalamus and is involved in the regulation of feeding., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q148P7;Q3U1L3;Q80T34", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:2001206 positive regulation of osteoclast development;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0032024 positive regulation of insulin secretion;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BFQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CE23-1", "uniprot_id": "OX26_MOUSE", "mass": 13485.0, "length": 124, "protein_name": "Orexigenic neuropeptide QRFP", "gene_name": "Qrfp", "organism": "Mouse", "refseq_name": "orexigenic neuropeptide QRFP preproprotein", "refseq_ac": "NP_906269", "gene_names_uniprotkb": "Qrfp", "gene_names_refseq": "P518; Qrfp", "protein_names_uniprotkb": "Orexigenic neuropeptide QRFP; Neuropeptide RF-amide; P518; Pyroglutamylated arginine-phenylalanine-amide peptide", "protein_names_refseq": "P518 precursor protein (P518); orexigenic neuropeptide QRFP preproprotein; orexigenic neuropeptide QRFP", "tax_id": 10090, "disease": "", "pathway": " (mmu:227717); (R-MMU-389397); (R-MMU-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12714592;12960173;15891009;16648250;17869477", "class_list": "", "function": "Characterization and tissue distribution of SP9155 (GPR103) ligand., [RefSeq, PubMed]; P518/26RFa is a neuropeptide that stimulates food intake in mice., [RefSeq, PubMed]; Qrfp polymorphisms is associated with osteopenia, [RefSeq, PubMed]; Stimulates feeding and grooming behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland., [UniProtKB, PubMed]; This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides QRFP-26 (26RFa) and the N-terminally extended form, QRFP-43 (43RFa). Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AV24", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0031854 orexigenic neuropeptide QRFP receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior;GO:0045777 positive regulation of blood pressure;GO:0060259 regulation of feeding behavior;GO:0007625 grooming behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CE23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3P1-1", "uniprot_id": "P2RX2_MOUSE", "mass": 53937.0, "length": 485, "protein_name": "P2X purinoceptor 2", "gene_name": "P2rx2", "organism": "Mouse", "refseq_name": "P2X purinoceptor 2 isoform b", "refseq_ac": "NP_001158305", "gene_names_uniprotkb": "P2rx2; P2x2", "gene_names_refseq": "P2X2a; P2rx2; P2x2", "protein_names_uniprotkb": "P2X purinoceptor 2; ATP receptor; P2X2; Purinergic receptor", "protein_names_refseq": "P2X purinoceptor 2 isoform b; P2X purinoceptor 2", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 41 (Disease Ontology:DOID:0110567)", "pathway": " (mmu:231602); (R-MMU-139853); (R-MMU-418346)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12361958;12690440;12917379;12937291;14672995;15961431;16322458;16467187;17706883;23345450", "class_list": "", "function": "ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (By similarity). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (PubMed:12917379, PubMed:12937291, PubMed:15961431, PubMed:16322458, PubMed:17706883, PubMed:23345450)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Heteromeric receptors formed by distinct P2XR subunits develop new functions resulting from integrative effects of the participating extracellular and C-terminal subdomains, [RefSeq, PubMed]; P2X(2) purine receptor immunoreactivity is a feature of intraganglionic laminar endings in the mouse, and that P2X receptor agonists may modulate sensitivity of the intraganglionic laminar endings, [RefSeq, PubMed]; P2X2 homomeric receptors contribute to fEPSPs in neural pathways underlying peristalsis studied in vitro., [RefSeq, PubMed]; P2X2 receptor subunit play a pivotal role in carotid body function and in mediating ventilatory responses to hypoxia., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3KP15;Q3TYV0;Q812E6;Q812E7", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling;GO:0030432 peristalsis;GO:0002931 response to ischemia;GO:0007274 neuromuscular synaptic transmission;GO:0007528 neuromuscular junction development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K3P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4K6-1", "uniprot_id": "PANK1_MOUSE", "mass": 60091.0, "length": 548, "protein_name": "Pantothenate kinase 1", "gene_name": "Pank1", "organism": "Mouse", "refseq_name": "pantothenate kinase 1 isoform 1", "refseq_ac": "NP_001107811", "gene_names_uniprotkb": "Pank1; Pank", "gene_names_refseq": "Pank1b; Pank1; Pank", "protein_names_uniprotkb": "Pantothenate kinase 1; 2.7.1.33; Pantothenic acid kinase 1; mPank1; mPank", "protein_names_refseq": "pantothenate kinase 1 isoform 1; pantothenic acid kinase 1", "tax_id": 10090, "disease": "pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981)", "pathway": " (mmu:75735); (R-MMU-196783)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10625688;12095677;16040613;17379144;20559429;21183079;21750661;22815849;23152917;32048816;34428180;34533403;36210013", "class_list": "", "function": "Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload., [RefSeq, PubMed]; Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; P53/PANK1/miR-107 signalling pathway spans the gap between metabolic reprogramming and insulin resistance induced by high-fat diet., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D3K1;Q9QXM8", "ec_number_list": "2.7.1.33", "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004594 pantothenate kinase activity;GO:1905502 acetyl-CoA binding", "go_cellular_component": "GO:0030118 clathrin coat;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8K4K6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4V5-1", "uniprot_id": "OIT3_MOUSE", "mass": 60316.0, "length": 546, "protein_name": "Oncoprotein-induced transcript 3 protein", "gene_name": "Oit3", "organism": "Mouse", "refseq_name": "oncoprotein-induced transcript 3 protein precursor", "refseq_ac": "NP_035089", "gene_names_uniprotkb": "Oit3; Lzp", "gene_names_refseq": "EF-9; LZP; Oit3", "protein_names_uniprotkb": "Oncoprotein-induced transcript 3 protein; Liver-specific zona pellucida domain-containing protein", "protein_names_refseq": "liver-specific zona pellucida domain-containing protein; oncoprotein-induced transcript 3 protein precursor; oncoprotein-induced transcript 3 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:18302)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12939600;15346761;18830570;22306318;25428506;30084848;33591966", "class_list": "", "function": "Data suggest that OIT3 could maintain urate homeostasis by regulating the excretion and reabsorption of uric acid in renal tubule via cooperating with THP., [RefSeq, PubMed]; LZP is required for hepatic triacylglycerol transportation through maintaining apolipoprotein B stability. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in hepatocellular function and development., [UniProtKB]; Mouse LZP localizes mostly on nuclear envelope, and at the same time, it can be secreted into blood in a truncated form., [RefSeq, PubMed]; The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P97806;Q811T0;Q8C9U1", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0009986 cell surface", "go_biological_process": "GO:0003014 renal system process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R4V5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VBW9-1", "uniprot_id": "10H28_MOUSE", "mass": 35748.0, "length": 316, "protein_name": "Olfactory receptor 10H28", "gene_name": "Or10h28", "organism": "Mouse", "refseq_name": "olfactory receptor 10H28", "refseq_ac": "NP_667148", "gene_names_uniprotkb": "Or10h28; Mor267-1; Olfr63", "gene_names_refseq": "M4; MOR267-1; Olfr63; Or10h28", "protein_names_uniprotkb": "Olfactory receptor 10H28; Odorant receptor M4; Olfactory receptor 267-1; Olfactory receptor 63", "protein_names_refseq": "GA_x6K02T2NTC5-9778-8828; odorant receptor M4; olfactory receptor 10H28; olfactory receptor 267-1; olfactory receptor 63", "tax_id": 10090, "disease": "", "pathway": " (mmu:258939)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VBW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEW2-1", "uniprot_id": "O5P73_MOUSE", "mass": 36888.0, "length": 330, "protein_name": "Olfactory receptor 5P73", "gene_name": "Or5p73", "organism": "Mouse", "refseq_name": "olfactory receptor 5P73", "refseq_ac": "NP_666419", "gene_names_uniprotkb": "Or5p73; Mor204-36; Olfr498", "gene_names_refseq": "MOR204-36; Olfr498; Or5p73", "protein_names_uniprotkb": "Olfactory receptor 5P73; Olfactory receptor 204-36; Olfactory receptor 498", "protein_names_refseq": "GA_x6K02T2PBJ9-10795522-10796514; olfactory receptor 204-36; olfactory receptor 498; olfactory receptor 5P73; olfactory receptor MOR204-36", "tax_id": 10090, "disease": "", "pathway": " (mmu:258304)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J0X9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VEW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEW5-1", "uniprot_id": "O5P68_MOUSE", "mass": 34953.0, "length": 314, "protein_name": "Olfactory receptor 5P68", "gene_name": "Or5p68", "organism": "Mouse", "refseq_name": "olfactory receptor 5P68", "refseq_ac": "NP_666422", "gene_names_uniprotkb": "Or5p68; Mor204-35; Olfr493", "gene_names_refseq": "MOR204-35; Olfr493; Or5p68", "protein_names_uniprotkb": "Olfactory receptor 5P68; Olfactory receptor 204-35; Olfactory receptor 493", "protein_names_refseq": "GA_x6K02T2PBJ9-10676998-10676054; olfactory receptor 204-35; olfactory receptor 493; olfactory receptor 5P68; olfactory receptor MOR204-35", "tax_id": 10090, "disease": "", "pathway": " (mmu:258307)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VEW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEX5-1", "uniprot_id": "O5H18_MOUSE", "mass": 34902.0, "length": 309, "protein_name": "Olfactory receptor 5H18", "gene_name": "Or5h18", "organism": "Mouse", "refseq_name": "olfactory receptor 5H18", "refseq_ac": "NP_666433", "gene_names_uniprotkb": "Or5h18; Mor183-9; Olfr186", "gene_names_refseq": "MOR183-9; Olfr186; Or5h18", "protein_names_uniprotkb": "Olfactory receptor 5H18; Olfactory receptor 183-9; Olfactory receptor 186", "protein_names_refseq": "olfactory receptor 183-9; olfactory receptor 186; olfactory receptor 5H18; olfactory receptor MOR183-9", "tax_id": 10090, "disease": "", "pathway": " (mmu:258318)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Activated by (+) and (-)-limonene., [UniProtKB, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKF2;Q9QUL1;Q9Z1U2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGI4-1", "uniprot_id": "O5P55_MOUSE", "mass": 34193.0, "length": 310, "protein_name": "Olfactory receptor 5P55", "gene_name": "Or5p55", "organism": "Mouse", "refseq_name": "olfactory receptor 5P55", "refseq_ac": "NP_667135", "gene_names_uniprotkb": "Or5p55; Mor204-3; Olfr476", "gene_names_refseq": "MOR204-3; Olfr476; Or5p55", "protein_names_uniprotkb": "Olfactory receptor 5P55; Olfactory receptor 204-3; Olfactory receptor 476", "protein_names_refseq": "GA_x6K02T2PBJ9-10296787-10297719; olfactory receptor 204-3; olfactory receptor 476; olfactory receptor 5P55; olfactory receptor MOR204-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:258926)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VGI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGI5-1", "uniprot_id": "OR5P4_MOUSE", "mass": 34348.0, "length": 312, "protein_name": "Olfactory receptor 5P4", "gene_name": "Or5p4", "organism": "Mouse", "refseq_name": "olfactory receptor 5P4", "refseq_ac": "NP_667136", "gene_names_uniprotkb": "Or5p4; Mor204-2; Olfr481", "gene_names_refseq": "MOR204-2; MOR204-39; Olfr481; Or5p4", "protein_names_uniprotkb": "Olfactory receptor 5P4; Olfactory receptor 204-2; Olfactory receptor 481", "protein_names_refseq": "GA_x6K02T2PBJ9-10409785-10410723; olfactory receptor 204-2; olfactory receptor 481; olfactory receptor 5P4; olfactory receptor MOR204-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:258927)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VGI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGI6-1", "uniprot_id": "O5P56_MOUSE", "mass": 34141.0, "length": 310, "protein_name": "Olfactory receptor 5P56", "gene_name": "Or5p56", "organism": "Mouse", "refseq_name": "olfactory receptor 5P56", "refseq_ac": "NP_667137", "gene_names_uniprotkb": "Or5p56; Mor204-1; Olfr477", "gene_names_refseq": "MOR204-1; Olfr477; Or5p56", "protein_names_uniprotkb": "Olfactory receptor 5P56; Olfactory receptor 204-1; Olfactory receptor 477", "protein_names_refseq": "GA_x6K02T2PBJ9-10319672-10320604; olfactory receptor 204-1; olfactory receptor 477; olfactory receptor 5P56; olfactory receptor MOR204-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:258928)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VGI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VGK5-1", "uniprot_id": "O1J21_MOUSE", "mass": 34794.0, "length": 312, "protein_name": "Olfactory receptor 1J21", "gene_name": "Or1j21", "organism": "Mouse", "refseq_name": "olfactory receptor 1J21", "refseq_ac": "NP_667157", "gene_names_uniprotkb": "Or1j21; Mor136-6; Olfr50", "gene_names_refseq": "ID3; MOR136-6; Olfr50; Or1j21", "protein_names_uniprotkb": "Olfactory receptor 1J21; Olfactory receptor 136-6; Olfactory receptor 50; Olfactory receptor I-D3", "protein_names_refseq": "GA_x6K02T2NLDC-33487752-33488690; olfactory receptor 136-6; olfactory receptor 1J21; olfactory receptor 50; olfactory receptor I-D3; olfactory receptor MOR136-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:18350)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9875846", "class_list": "", "function": "Odorant receptor. Activated by (+) and (-)-carvone., [UniProtKB, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1U9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0019840 isoprenoid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VGK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZD1-1", "uniprot_id": "OSR2_MOUSE", "mass": 35454.0, "length": 312, "protein_name": "Protein odd-skipped-related 2", "gene_name": "Osr2", "organism": "Mouse", "refseq_name": "protein odd-skipped-related 2 isoform 2", "refseq_ac": "NP_473390", "gene_names_uniprotkb": "Osr2", "gene_names_refseq": "5430409I15Rik; Osr2A; Osr2B; Osr2", "protein_names_uniprotkb": "Protein odd-skipped-related 2", "protein_names_refseq": "protein odd-skipped-related 2 isoform 2; protein odd-skipped-related 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:107587)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11520675;15175245;15670784;16436053;25428506;27713059;30084848", "class_list": "", "function": "Expressed during craniofacial, limb, and kidney development, [RefSeq, PubMed]; May be involved in the development of the mandibular molar tooth germ at the bud stage., [UniProtKB, PubMed]; Osr2 expression is regulated by C/EBP regulatory elements, [RefSeq, PubMed]; Osr2 is a key intrinsic regulator of palatal growth and patterning, [RefSeq, PubMed]; Our results indicate that Osr2 bifurcates its function by alternative splicing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPV6;Q91V54", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0033687 osteoblast proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91ZD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923D3-1", "uniprot_id": "PARM1_MOUSE", "mass": 30667.0, "length": 296, "protein_name": "Prostate androgen-regulated mucin-like protein 1 homolog", "gene_name": "Parm1", "organism": "Mouse", "refseq_name": "prostate androgen-regulated mucin-like protein 1 homolog precursor", "refseq_ac": "NP_663537", "gene_names_uniprotkb": "Parm1", "gene_names_refseq": "2210012L08Rik; 9130213B05Rik; Parm1", "protein_names_uniprotkb": "Prostate androgen-regulated mucin-like protein 1 homolog; PARM-1", "protein_names_refseq": "PARM-1; prostate androgen-regulated mucin-like protein 1 homolog precursor; prostate androgen-regulated mucin-like protein 1 homolog; prostatic androgen-repressed message-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231440)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;19966531;37047359", "class_list": "", "function": "May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis., [UniProtKB]; PARM1 Drives Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension via AKT/FOXO3A Axis. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate that mPARM-1 might be involved in the regulation of fat accumulation and adipocyte differentiation., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A5JSU4;Q3TTV0;Q3UFU4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q923D3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LX8-1", "uniprot_id": "OST4_MOUSE", "mass": 4193.0, "length": 37, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4", "gene_name": "Ost4", "organism": "Mouse", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4", "refseq_ac": "NP_001128164", "gene_names_uniprotkb": "Ost4", "gene_names_refseq": "2310016E02Rik; Ost4", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4; oligosaccharyltransferase 4 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67695); (R-MMU-9768727); (R-MMU-9931295)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "16075062;16479539;22872234;30084848;31219806;34428180", "class_list": "glycogene", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A;GO:0160227 oligosaccharyltransferase complex B", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99LX8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZ30-1", "uniprot_id": "OLA1_MOUSE", "mass": 44730.0, "length": 396, "protein_name": "Obg-like ATPase 1", "gene_name": "Ola1", "organism": "Mouse", "refseq_name": "obg-like ATPase 1 isoform a", "refseq_ac": "NP_080218", "gene_names_uniprotkb": "Ola1; Gtpbp9", "gene_names_refseq": "2510025G09Rik; 2810405J23Rik; 2810409H07Rik; Gtpbp9; Ola1; PTD004", "protein_names_uniprotkb": "Obg-like ATPase 1; GTP-binding protein 9", "protein_names_refseq": "GTP-binding protein 9 (putative); GTP-binding protein PTD004; obg-like ATPase 1 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:67059); (R-MMU-114608)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;26984302;27481995;33300544;34428180;38537683", "class_list": "", "function": "Cell transformation induced by the metal mixture NaAsO2, CdCl2, and Pb(C2H3O2)2.3H2O through ROS generation was rescued by OLA1 knockdown during the initiation stage of morphological transformation., [RefSeq, PubMed]; Data demonstrate that OLA1 is required for normal progression of mammalian development. OLA1 plays an important role in promoting cell proliferation at least in part through suppression of p21 and organogenesis via factors yet to be discovered. Publication Status: Online-Only, [RefSeq, PubMed]; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP., [UniProtKB, HAMAP]; Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AYJ8;B1AYK0;Q9CWE2;Q9CX91;Q9CYC9;Q9CZ56", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0046034 ATP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CZ30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D136-1", "uniprot_id": "OGFD3_MOUSE", "mass": 35385.0, "length": 315, "protein_name": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3", "gene_name": "Ogfod3", "organism": "Mouse", "refseq_name": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3", "refseq_ac": "NP_079678", "gene_names_uniprotkb": "Ogfod3", "gene_names_refseq": "1110031I02Rik; Ogfod3", "protein_names_uniprotkb": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3; 1.14.11.-", "protein_names_refseq": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3; PKHD domain-containing transmembrane protein C17orf101 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66179)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;30899004;31599954;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0051213 dioxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D136-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7E3-1", "uniprot_id": "OVCA2_MOUSE", "mass": 24246.0, "length": 225, "protein_name": "Esterase OVCA2", "gene_name": "Ovca2", "organism": "Mouse", "refseq_name": "esterase OVCA2", "refseq_ac": "NP_081412", "gene_names_uniprotkb": "Ovca2", "gene_names_refseq": "9030414M07Rik; Ovca2", "protein_names_uniprotkb": "Esterase OVCA2; 3.1.1.1; OVCA2 serine hydrolase domain-containing protein; Ovarian cancer-associated gene 2 protein homolog", "protein_names_refseq": "OVCA2 serine hydrolase domain-containing protein; candidate tumor suppressor OVCA2; esterase OVCA2; ortholog of human candidate tumor suppressor in ovarian cancer 2 OVCA2; ovarian cancer-associated gene 2 protein homolog", "tax_id": 10090, "disease": "ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (mmu:246257)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11527402", "class_list": "", "function": "Exhibits ester hydrolase activity with a strong preference for long-chain alkyl ester substrates and high selectivity against a variety of short, branched, and substituted esters. Is able to hydrolyze ester bonds within a wide range of p-nitrophenyl derivatives (C2-C14) in vitro, with a strong preference toward substrates of >8 carbons., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.1;3.1.1.-;3.1.1.13;3.1.1.67", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D7E3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8I2-1", "uniprot_id": "P2Y13_MOUSE", "mass": 38727.0, "length": 337, "protein_name": "P2Y purinoceptor 13", "gene_name": "P2ry13", "organism": "Mouse", "refseq_name": "P2Y purinoceptor 13", "refseq_ac": "NP_083084", "gene_names_uniprotkb": "P2ry13; Gpr86", "gene_names_refseq": "2010001L06Rik; GPCR1; GPR94; Gpr86; P2Y13; P2ry13; P2yr13; SP174", "protein_names_uniprotkb": "P2Y purinoceptor 13; G protein-coupled receptor 86; P2Y13", "protein_names_refseq": "G protein-coupled receptor 68; G protein-coupled receptor 86; P2Y purinoceptor 13; Vpurinergic receptor P2Y, G-protein coupled 13; purinergic receptor P2Y13", "tax_id": 10090, "disease": "", "pathway": " (mmu:74191); (R-MMU-417957); (R-MMU-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;19915796;34860143;38470490", "class_list": "", "function": "P2Y13 receptor deficiency favors adipose tissue lipolysis and worsens insulin resistance and fatty liver disease. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system (By similarity)., [UniProtKB]; Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma., [RefSeq, PubMed]; The brackage of P2ry13 protein receptor results in enhanced ERK1/2, Akt/PKB and CREB phosphorylation mechanisms involved in beta-cell survival., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0VF10;Q8C412;Q8CAL2", "ec_number_list": "", "go_molecular_function": "GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D8I2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCU0-1", "uniprot_id": "PAQR5_MOUSE", "mass": 38151.0, "length": 330, "protein_name": "Membrane progestin receptor gamma", "gene_name": "Paqr5", "organism": "Mouse", "refseq_name": "membrane progestin receptor gamma isoform 1", "refseq_ac": "NP_083024", "gene_names_uniprotkb": "Paqr5; Mprg", "gene_names_refseq": "0610010I15Rik; Paqr5; mPRg", "protein_names_uniprotkb": "Membrane progestin receptor gamma; Membrane progesterone P4 receptor gamma; Membrane progesterone receptor gamma; Progesterone and adipoQ receptor family member 5; Progestin and adipoQ receptor family member 5; Progestin and adipoQ receptor family member V; mPR gamma", "protein_names_refseq": "mPR gamma; membrane progesterone P4 receptor gamma; membrane progesterone receptor gamma; membrane progestin receptor gamma isoform 1; membrane progestin receptor gamma; progesterone and adipoQ receptor family member 5; progestin and adipoQ receptor family member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:74090)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16044242", "class_list": "", "function": "Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPQ5;Q8C6Z8", "ec_number_list": "", "go_molecular_function": "GO:0005496 steroid binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DCU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESF1-1", "uniprot_id": "OTOF_MOUSE", "mass": 227033.0, "length": 1997, "protein_name": "Otoferlin", "gene_name": "Otof", "organism": "Mouse", "refseq_name": "otoferlin isoform 1", "refseq_ac": "NP_001093865", "gene_names_uniprotkb": "Otof; Fer1l2", "gene_names_refseq": "Otof", "protein_names_uniprotkb": "Otoferlin; Fer-1-like protein 2; Protein pachanga", "protein_names_refseq": "fer-1-like protein 2; otoferlin isoform 1; protein pachanga", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 9 (Disease Ontology:DOID:0110535); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (mmu:83762)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10192385;10903124;17055430;17229086;17329413;18287496;18772196;21750661;34428180;41091875", "class_list": "", "function": "Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Otoferlin is essential for a late step of synaptic vesicle exocytosis and may act as the major Ca(2+) sensor triggering membrane fusion at the auditory inner hair cell ribbon synapse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A3KLM3;B2RWU0;Q8CCE7;Q9ESF2", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0035612 AP-2 adaptor complex binding;GO:0044877 protein-containing complex binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0060203 clathrin-sculpted glutamate transport vesicle membrane;GO:0048787 presynaptic active zone membrane;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0001964 startle response;GO:0007009 plasma membrane organization;GO:0010996 response to auditory stimulus;GO:0007605 sensory perception of sound;GO:0036465 synaptic vesicle recycling", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9ESF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHB2-1", "uniprot_id": "O7A40_MOUSE", "mass": 34661.0, "length": 309, "protein_name": "Olfactory receptor 7A40", "gene_name": "Or7a40", "organism": "Mouse", "refseq_name": "olfactory receptor 7A40", "refseq_ac": "NP_666447", "gene_names_uniprotkb": "Or7a40; Mor140-1; Olfr19", "gene_names_refseq": "M12; MOR140-1; MTPCR15; Olfr19; Or7a40", "protein_names_uniprotkb": "Olfactory receptor 7A40; Odorant receptor M12; Olfactory receptor 140-1; Olfactory receptor 19", "protein_names_refseq": "GA_x54KRFPKG5P-13123979-13123050; odorant receptor M12; olfactory receptor 140-1; olfactory receptor 19; olfactory receptor 7A40; olfactory receptor MOR140-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18316)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10706615;32061665", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; This odorant receptor, Olfr19, responds to the odorant whiskey lactone in both in vivo and in vitro assays., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JM32", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JHB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJE4-1", "uniprot_id": "PAQR4_MOUSE", "mass": 29215.0, "length": 273, "protein_name": "Progestin and adipoQ receptor family member 4", "gene_name": "Paqr4", "organism": "Mouse", "refseq_name": "progestin and adipoQ receptor family member 4", "refseq_ac": "NP_076313", "gene_names_uniprotkb": "Paqr4; MNCb-0914", "gene_names_refseq": "1500004C10Rik; Paqr4", "protein_names_uniprotkb": "Progestin and adipoQ receptor family member 4; Progestin and adipoQ receptor family member IV", "protein_names_refseq": "progestin and adipoQ receptor family member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:76498)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16044242;38961186", "class_list": "", "function": "Plays a role in maintaining adipose tissue function through the regulation of ceramide levels (PubMed:38961186). Mediates the stability of ceramide synthetases, CERS2 and CERS5, and their activities (PubMed:38961186)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7G1", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:2000303 regulation of ceramide biosynthetic process;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJS7-1", "uniprot_id": "P2RY4_MOUSE", "mass": 41034.0, "length": 361, "protein_name": "P2Y purinoceptor 4", "gene_name": "P2ry4", "organism": "Mouse", "refseq_name": "P2Y purinoceptor 4", "refseq_ac": "NP_065646", "gene_names_uniprotkb": "P2ry4; P2y4r", "gene_names_refseq": "P2Y4R; P2Y4; P2ry4", "protein_names_uniprotkb": "P2Y purinoceptor 4; P2Y4", "protein_names_refseq": "P2Y purinoceptor 4; P2Y4 receptor; purinergic receptor P2Y, G-protein coupled, 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:57385); (R-MMU-417957); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11290369;12644577;12814360;27855539;28322086;36248854", "class_list": "", "function": "Central role of PD-L1 in cardioprotection resulting from P2Y4 nucleotide receptor loss. Erratum:[Front Immunol. 2022 Oct 28;13:1061958. doi: 10.3389/fimmu.2022.1061958. PMID: 36389796] Publication Status: Online-Only, [RefSeq, PubMed]; In the brain samples, expressions of P2Y4 and P2X7 were significantly reduced, whereas that of P2Y1 was significantly elevated in an age-dependent manner., [RefSeq, PubMed]; Knock-out mice reveal tissue-specific roles of P2Y receptor subtypes in different epithelia., [RefSeq, PubMed]; Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro., [RefSeq, PubMed]; Receptor for ATP and UTP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]; These data highlight the P2Y4 receptor as an inhibitor of cardiac fat formation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019103 pyrimidine nucleotide binding;GO:0045030 G protein-coupled UTP receptor activity;GO:0005524 ATP binding;GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0071380 cellular response to prostaglandin E stimulus;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration;GO:0030321 transepithelial chloride transport;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJX6-1", "uniprot_id": "P2RX4_MOUSE", "mass": 43438.0, "length": 388, "protein_name": "P2X purinoceptor 4", "gene_name": "P2rx4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "P2rx4; P2x4", "gene_names_refseq": "", "protein_names_uniprotkb": "P2X purinoceptor 4; ATP receptor; P2X4; Purinergic receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:18438); (R-MMU-139853); (R-MMU-418346)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17299767;17947660;21750661;26456657;27477609;28011936;30084848;30899004;31599954;34428180;35119925", "class_list": "", "function": "ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:26456657, PubMed:35119925). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (PubMed:35119925). Also participates in basal T-cell activity without TCR/CD3 stimulation (PubMed:35119925). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (By similarity). Upon activation, drives microglia motility via the PI3K/Akt pathway (PubMed:17299767). Could also function as an ATP-gated cation channel of lysosomal membranes (PubMed:27477609)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJX3;Q9JJX4;Q9JJX5", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0045296 cadherin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:1904141 positive regulation of microglial cell migration;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0050975 sensory perception of touch;GO:0002931 response to ischemia;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9JJX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QY00-1", "uniprot_id": "O5G26_MOUSE", "mass": 35901.0, "length": 318, "protein_name": "Olfactory receptor 5G26", "gene_name": "Or5g26", "organism": "Mouse", "refseq_name": "olfactory receptor 5G26", "refseq_ac": "NP_038756", "gene_names_uniprotkb": "Or5g26; Mor175-1; Olfr154; Olfr4-3; Or912-93; Or93", "gene_names_refseq": "912-93; MOR175-1; OR93; Olfr154; Olfr4-3; Or5g26", "protein_names_uniprotkb": "Olfactory receptor 5G26; Olfactory receptor 154; Olfactory receptor 175-1", "protein_names_refseq": "GA_x6K02T2Q125-47143827-47142871; olfactory receptor 154; olfactory receptor 175-1; olfactory receptor 4 cluster, gene 3; olfactory receptor 5G26; olfactory receptor MOR175-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27216)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10594242", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ALD1;Q0VBG5", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QY00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTJ2-1", "uniprot_id": "OVOL1_MOUSE", "mass": 30222.0, "length": 267, "protein_name": "Putative transcription factor Ovo-like 1", "gene_name": "Ovol1", "organism": "Mouse", "refseq_name": "putative transcription factor Ovo-like 1", "refseq_ac": "NP_064319", "gene_names_uniprotkb": "Ovol1", "gene_names_refseq": "Ovo1; Ovol1; movo1", "protein_names_uniprotkb": "Putative transcription factor Ovo-like 1; mOvo1a; mOvo1", "protein_names_refseq": "OVO homolog-like 1; mOvo1a; putative transcription factor Ovo-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18426)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11983900;15716349;17049212;21750661;34461129;9808631", "class_list": "", "function": "Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation., [RefSeq, PubMed]; Ovol1 mutant mice suffered perinatal lethality accompanied by kidney epithelial cysts of embryonic onset and delayed skin barrier acquisition; Ovol2 is a downstream target of Ovol1., [RefSeq, PubMed]; Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system., [UniProtKB, PubMed]; Regulates pachytene progression of male germ cells, Id2 is target, [RefSeq, PubMed]; The LEF1/beta -catenin complex activates movo1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545S2", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1901994 negative regulation of meiotic cell cycle phase transition;GO:0009913 epidermal cell differentiation;GO:2000647 negative regulation of stem cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WTJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVF6-1", "uniprot_id": "PA2GD_MOUSE", "mass": 16164.0, "length": 144, "protein_name": "Group IID secretory phospholipase A2", "gene_name": "Pla2g2d", "organism": "Mouse", "refseq_name": "group IID secretory phospholipase A2 isoform 2", "refseq_ac": "NP_001334159", "gene_names_uniprotkb": "Pla2g2d; Pla2a2; Splash", "gene_names_refseq": "GIID sPLA2; GIID; PLA2IID; Pla2g2d; Splash; mGIID; sPLA2-IID", "protein_names_uniprotkb": "Group IID secretory phospholipase A2; 3.1.1.4; GIID sPLA2; PLA2IID; Phosphatidylcholine 2-acylhydrolase 2D; Secretory-type PLA, stroma-associated homolog; sPLA2-IID", "protein_names_refseq": "group IID secretory phospholipase A2 isoform 2; group IID secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 2D; secretory-type PLA, stroma-associated homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:18782); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483166)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "10383420;10455175;10531313;11196711;11694541;19564598;23690440;26392224;27226632;32375030;34060490;34428180;36210013", "class_list": "", "function": "Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D., [RefSeq, PubMed]; Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing omega3 Polyunsaturated Fatty Acids in WAT., [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10531313, PubMed:23690440, PubMed:26392224). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (PubMed:23690440). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (PubMed:23690440, PubMed:27226632). May act in an autocrine and paracrine manner. Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (PubMed:19564598). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V4B8;Q9JLK0", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;3.1.1.5;2.3.1.43;3.1.1.47;3.1.2.2;3.1.1.3;2.3.1.-;3.1.1.-;3.1.1.32;2.3.1.51;3.1.1.23;3.1.-.-", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0006954 inflammatory response;GO:0016042 lipid catabolic process;GO:0042130 negative regulation of T cell proliferation;GO:0050482 arachidonate secretion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9WVF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z183-1", "uniprot_id": "PADI4_MOUSE", "mass": 74415.0, "length": 666, "protein_name": "Protein-arginine deiminase type-4", "gene_name": "Padi4", "organism": "Mouse", "refseq_name": "protein-arginine deiminase type-4", "refseq_ac": "NP_035191", "gene_names_uniprotkb": "Padi4; Pad4; Pdi4", "gene_names_refseq": "Pad4; Padi4; Pdi4", "protein_names_uniprotkb": "Protein-arginine deiminase type-4; 3.5.3.15; Peptidylarginine deiminase IV; Protein-arginine deiminase type IV", "protein_names_refseq": "PAD type IV; peptidylarginine deiminase IV; protein-arginine deiminase type IV; protein-arginine deiminase type-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:18602); (R-MMU-3247509)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10092850;15087120;15339660;20733033;23650392;24463520;25428506;25622091;28011936;30084848;30779550;31209405;32170015;32528174;34428180;38956325", "class_list": "", "function": "Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:32528174). Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) (PubMed:15339660). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance (PubMed:24463520, PubMed:32528174). Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (PubMed:20733033, PubMed:23650392). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription (By similarity). Involved for the formation of neutrophil extracellular traps (NETs) by mediating citrullination of histone H3 and initiating decondensation of chromatin and nuclear membrane rupture (PubMed:20733033, PubMed:32528174, PubMed:32170015, PubMed:25622091). NETs are mainly composed of DNA fibers and are released by neutrophils to trap pathogens during inflammation (PubMed:20733033, PubMed:32528174, PubMed:32170015, PubMed:25622091). Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AMU3;Q75WC7", "ec_number_list": "3.5.3.15", "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0140794 histone arginine deiminase activity;GO:0140795 histone H3R2 arginine deiminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0043687 post-translational protein modification;GO:0045087 innate immune response;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z183-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z185-1", "uniprot_id": "PADI1_MOUSE", "mass": 73824.0, "length": 662, "protein_name": "Protein-arginine deiminase type-1", "gene_name": "Padi1", "organism": "Mouse", "refseq_name": "protein-arginine deiminase type-1", "refseq_ac": "NP_035189", "gene_names_uniprotkb": "Padi1; Pad1; Pdi1", "gene_names_refseq": "Padi1; Pdi1", "protein_names_uniprotkb": "Protein-arginine deiminase type-1; 3.5.3.15; Peptidylarginine deiminase I; Protein-arginine deiminase type I", "protein_names_refseq": "PAD type I; PROTEIN-ARGININE DEIMINASE TYPE I (PEPTIDYLARGININE DEIMINASE I); Pad type 1; peptidylarginine deiminase I; protein-arginine deiminase type-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18599); (R-MMU-3247509)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10092850;15087120;1778991;30084848;31219806;36210013", "class_list": "", "function": "Catalyzes the deimination of arginine residues of proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.3.15", "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z185-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1V0-1", "uniprot_id": "OR6E1_MOUSE", "mass": 35689.0, "length": 313, "protein_name": "Olfactory receptor 6E1", "gene_name": "Or6e1", "organism": "Mouse", "refseq_name": "olfactory receptor 6E1", "refseq_ac": "NP_035121", "gene_names_uniprotkb": "Or6e1; Mor118-1; Olfr49", "gene_names_refseq": "IC6; MOR1181; Olfr49; Or6e1", "protein_names_uniprotkb": "Olfactory receptor 6E1; Olfactory receptor 118-1; Olfactory receptor 49; Olfactory receptor I-C6", "protein_names_refseq": "olfactory receptor 118-1; olfactory receptor 49; olfactory receptor 6E1; olfactory receptor I-C6", "tax_id": 10090, "disease": "", "pathway": " (mmu:18348)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9875846", "class_list": "", "function": "Odorant receptor. Activated by (-)-citronellal and to a lesser extent by (+)-citronellal. Not activated by carvone or limonene., [UniProtKB, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VFB7", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0019840 isoprenoid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z1V0-1", "record_type": "protein" } ]